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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FYTTD1-RPL35A (FusionGDB2 ID:31833)

Fusion Gene Summary for FYTTD1-RPL35A

Fusion gene summary

Fusion gene information	Fusion gene name: FYTTD1-RPL35A
	Fusion gene ID: 31833
		Hgene	Tgene
	Gene symbol	FYTTD1	RPL35A
	Gene ID	84248	6165
	Gene name	forty-two-three domain containing 1	ribosomal protein L35a
	Synonyms	UIF	DBA5\|L35A\|eL33
	Cytomap	3q29	3q29
	Type of gene	protein-coding	protein-coding
	Description	UAP56-interacting factorforty-two-three domain-containing protein 1protein 40-2-3	60S ribosomal protein L35acell growth-inhibiting gene 33 proteinlarge ribosomal subunit protein eL33
	Modification date	20200313	20200313
	UniProtAcc	Q96QD9	.
	Ensembl transtripts involved in fusion gene	ENST00000415708, ENST00000428395, ENST00000241502, ENST00000424384, ENST00000492360,	ENST00000464167, ENST00000329092, ENST00000448864,
Fusion gene scores	* DoF score	7 X 7 X 6=294	11 X 12 X 4=528
	# samples	7	14
	** MAII score	log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/528*10)=-1.91511110241349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FYTTD1 [Title/Abstract] AND RPL35A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FYTTD1(197503872)-RPL35A(197680874), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across FYTTD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RPL35A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-85-8664-01A	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+

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Fusion Gene ORF analysis for FYTTD1-RPL35A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000415708	ENST00000464167	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+
5CDS-3UTR	ENST00000415708	ENST00000329092	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+
5CDS-3UTR	ENST00000415708	ENST00000448864	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+
In-frame	ENST00000428395	ENST00000464167	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+
5CDS-3UTR	ENST00000428395	ENST00000329092	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+
5CDS-3UTR	ENST00000428395	ENST00000448864	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+
In-frame	ENST00000241502	ENST00000464167	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+
5CDS-3UTR	ENST00000241502	ENST00000329092	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+
5CDS-3UTR	ENST00000241502	ENST00000448864	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+
In-frame	ENST00000424384	ENST00000464167	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+
5CDS-3UTR	ENST00000424384	ENST00000329092	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+
5CDS-3UTR	ENST00000424384	ENST00000448864	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+
intron-3CDS	ENST00000492360	ENST00000464167	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+
intron-3UTR	ENST00000492360	ENST00000329092	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+
intron-3UTR	ENST00000492360	ENST00000448864	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000415708

FYTTD1

chr3

197503872

ENST00000464167

RPL35A

chr3

197680874

1897

891

238

1059

273

ENST00000428395

FYTTD1

chr3

197503872

ENST00000464167

RPL35A

chr3

197680874

1897

891

238

1059

273

ENST00000241502

FYTTD1

chr3

197503872

ENST00000464167

RPL35A

chr3

197680874

1959

953

144

1121

325

ENST00000424384

FYTTD1

chr3

197503872

ENST00000464167

RPL35A

chr3

197680874

2067

1061

408

1229

273

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000415708	ENST00000464167	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+	0.01951231	0.98048776
ENST00000428395	ENST00000464167	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+	0.01951231	0.98048776
ENST00000241502	ENST00000464167	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+	0.042139973	0.95786005
ENST00000424384	ENST00000464167	FYTTD1	chr3	197503872	+	RPL35A	chr3	197680874	+	0.05435186	0.94564813

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Fusion Genomic Features for FYTTD1-RPL35A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
FYTTD1	chr3	197503872	+	RPL35A	chr3	197680873	+	1.97E-11	1
FYTTD1	chr3	197503872	+	RPL35A	chr3	197680873	+	1.97E-11	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FYTTD1-RPL35A

Go to
FGviewer for the breakpoints of chr3:197503872-chr3:197680874
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FYTTD1 Q96QD9	.
FUNCTION: Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4. {ECO:0000269\|PubMed:19836239}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FYTTD1

chr3:197503872

chr3:197680874

ENST00000241502

26_44

243.66666666666666

319.0

Motif

Note=UAP56-binding motif

Hgene

FYTTD1

chr3:197503872

chr3:197680874

ENST00000415708

26_44

217.66666666666666

293.0

Motif

Note=UAP56-binding motif

Hgene

FYTTD1

chr3:197503872

chr3:197680874

ENST00000424384

26_44

176.66666666666666

252.0

Motif

Note=UAP56-binding motif

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for FYTTD1-RPL35A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000415708_ENST00000464167_TCGA-85-8664-01A_FYTTD1_chr3_197503872_+_RPL35A_chr3_197680874_length(transcript)=1897nt_BP=891nt
GAAAGGCTCGTGTGTACCGAAGTATAGGGGACCTGTCTGCAGCAGGAGGGACTCGAAGGACACGGAGGATTATATCACTGAAGGCATAAG
ATTCAGAGTAGAGACGGGATTTCACCATGTTGGTCAGGCCAGTCCCGAACTCCTGACCTCAAATGATCCGCCCACCTCAGCCTCCCAAAG
TGCTGGGATTATAGGTGTGAGTCACCATGCCTGGCCGGAAGGGGGTCATCTTTAAAAAATGGAGCCTTCTGTGATTATGGGAAATGATAT
CATCAAGTTGAATCGAAAGGAAGGGAAGAAGCAGAATTTTCCAAGACTAAATAGAAGACTCCTCCAGCAAAGTGGTGCCCAGCAATTCAG
GATGAGAGTGCGATGGGGAATCCAACAGAATTCTGGTTTTGGTAAGACTAGTCTGAATCGTAGAGGAAGAGTAATGCCTGGAAAGAGACG
TCCTAATGGAGTTATCACTGGCCTTGCAGCTAGGAAAACGACTGGAATTCGAAAAGGAATTAGTCCTATGAATCGTCCACCTCTAAGTGA
CAAGAATATAGAACAATATTTTCCAGTGTTAAAAAGGAAGGCAAACCTTCTGAGACAAAATGAAGGGCAGAGGAAACCAGTAGCAGTTCT
CAAGAGACCTAGCCAGCTAAGCAGAAAAAATAACATTCCAGCTAATTTTACCAGGAGTGGAAATAAATTAAATCATCAGAAAGATACTCG
TCAGGCAACTTTTCTTTTCAGAAGAGGCCTGAAGGTGCAGGCCCAGTTGAATACAGAACAACTGCTAGACGATGTAGTAGCAAAGAGAAC
TCGTCAATGGCGGACTTCCACCACAAATGGAGGGATTTTGACTGTATCTATTGACAATCCTGGAGCAGTGCAATGCCCAGTCAACACAGT
CACTCCTGGCGGCAAACCAAACAAAACCAGAGTCATCTGGGGAAAAGTAACTCGGGCCCATGGAAACAGTGGCATGGTTCGTGCCAAATT
CCGAAGCAATCTTCCTGCTAAGGCCATTGGACACAGAATCCGAGTGATGCTGTACCCCTCAAGGATTTAAACTAACGAAAAATCAATAAA
TAAATGTGGATTTGTGCTCTTGTATTTTTAAGTGGATTAAAAAACTTACTACCTTAAATTGATTTGCTACATGCTTAAAATGATAGAGGT
TGCTCAGCATTTTTGGAGTACAAGGGGGTCAGAGAGACATGTGATGAAAATTACAGGGCGAGTACAGAGATTTAGAAGGGAACGGGTTTT
AATGCGAGTATCTTTGACAGAGTCTTGCTCTGTTGCCCATGCTGGAGTGTAGTGGTGCTCGCTGCAGCCTCACATTCAAAGGCTCAAGCA
ATCCTCCCTTGGCCTTTGAAGTAGCTGGGACCACAGGCTCATGCCACCATCCCTGGGTCATTTTTAAATTTTTTGTAGAGAGGGTCTGAC
TCTTGCCTATGCTGGCTTCAAACTCCTGGGCTCAAGCAATCCTCCTTCCTTGGCCTCTCCTGAAGTGCTGGGATACAGTTATGAGCCACC
ACACCTGCCAAGTGCTTTGTGATACTATGCATTTGTTCAATGCAGATTGGGAAACTTAAAATTTGAATGGAGATTATGTTGATGGGCTTT
GGCAGTTCATTTGGATAGACTGGGATGAGAAGCTCTTGGGACTTGTGACTGGACAAAGCATTCCAGTATATTAAAATAAAATTAAGCCAT
ATTACTCCACTCATAAAAAGCAATCCTATGGTAGGTACATGGAGGTTGGGAATAGTGCACGGAAAGGTGGCAGCTTTCTTTGGCTTCATG
TTTTAATCTGGTAAAGTTCAAGATTGCACTTTAAGCAGGCCTCCTAAATATTTTAGATTTCTTGGGGATATGCTAAAATAAAACAACTAA

>In-frame_ENST00000415708_ENST00000464167_TCGA-85-8664-01A_FYTTD1_chr3_197503872_+_RPL35A_chr3_197680874_length(amino acids)=273AA_start in transcript=238_stop in transcript=1059
MEPSVIMGNDIIKLNRKEGKKQNFPRLNRRLLQQSGAQQFRMRVRWGIQQNSGFGKTSLNRRGRVMPGKRRPNGVITGLAARKTTGIRKG
ISPMNRPPLSDKNIEQYFPVLKRKANLLRQNEGQRKPVAVLKRPSQLSRKNNIPANFTRSGNKLNHQKDTRQATFLFRRGLKVQAQLNTE
QLLDDVVAKRTRQWRTSTTNGGILTVSIDNPGAVQCPVNTVTPGGKPNKTRVIWGKVTRAHGNSGMVRAKFRSNLPAKAIGHRIRVMLYP

--------------------------------------------------------------
>In-frame_ENST00000428395_ENST00000464167_TCGA-85-8664-01A_FYTTD1_chr3_197503872_+_RPL35A_chr3_197680874_length(transcript)=1897nt_BP=891nt
GAAAGGCTCGTGTGTACCGAAGTATAGGGGACCTGTCTGCAGCAGGAGGGACTCGAAGGACACGGAGGATTATATCACTGAAGGCATAAG
ATTCAGAGTAGAGACGGGATTTCACCATGTTGGTCAGGCCAGTCCCGAACTCCTGACCTCAAATGATCCGCCCACCTCAGCCTCCCAAAG
TGCTGGGATTATAGGTGTGAGTCACCATGCCTGGCCGGAAGGGGGTCATCTTTAAAAAATGGAGCCTTCTGTGATTATGGGAAATGATAT
CATCAAGTTGAATCGAAAGGAAGGGAAGAAGCAGAATTTTCCAAGACTAAATAGAAGACTCCTCCAGCAAAGTGGTGCCCAGCAATTCAG
GATGAGAGTGCGATGGGGAATCCAACAGAATTCTGGTTTTGGTAAGACTAGTCTGAATCGTAGAGGAAGAGTAATGCCTGGAAAGAGACG
TCCTAATGGAGTTATCACTGGCCTTGCAGCTAGGAAAACGACTGGAATTCGAAAAGGAATTAGTCCTATGAATCGTCCACCTCTAAGTGA
CAAGAATATAGAACAATATTTTCCAGTGTTAAAAAGGAAGGCAAACCTTCTGAGACAAAATGAAGGGCAGAGGAAACCAGTAGCAGTTCT
CAAGAGACCTAGCCAGCTAAGCAGAAAAAATAACATTCCAGCTAATTTTACCAGGAGTGGAAATAAATTAAATCATCAGAAAGATACTCG
TCAGGCAACTTTTCTTTTCAGAAGAGGCCTGAAGGTGCAGGCCCAGTTGAATACAGAACAACTGCTAGACGATGTAGTAGCAAAGAGAAC
TCGTCAATGGCGGACTTCCACCACAAATGGAGGGATTTTGACTGTATCTATTGACAATCCTGGAGCAGTGCAATGCCCAGTCAACACAGT
CACTCCTGGCGGCAAACCAAACAAAACCAGAGTCATCTGGGGAAAAGTAACTCGGGCCCATGGAAACAGTGGCATGGTTCGTGCCAAATT
CCGAAGCAATCTTCCTGCTAAGGCCATTGGACACAGAATCCGAGTGATGCTGTACCCCTCAAGGATTTAAACTAACGAAAAATCAATAAA
TAAATGTGGATTTGTGCTCTTGTATTTTTAAGTGGATTAAAAAACTTACTACCTTAAATTGATTTGCTACATGCTTAAAATGATAGAGGT
TGCTCAGCATTTTTGGAGTACAAGGGGGTCAGAGAGACATGTGATGAAAATTACAGGGCGAGTACAGAGATTTAGAAGGGAACGGGTTTT
AATGCGAGTATCTTTGACAGAGTCTTGCTCTGTTGCCCATGCTGGAGTGTAGTGGTGCTCGCTGCAGCCTCACATTCAAAGGCTCAAGCA
ATCCTCCCTTGGCCTTTGAAGTAGCTGGGACCACAGGCTCATGCCACCATCCCTGGGTCATTTTTAAATTTTTTGTAGAGAGGGTCTGAC
TCTTGCCTATGCTGGCTTCAAACTCCTGGGCTCAAGCAATCCTCCTTCCTTGGCCTCTCCTGAAGTGCTGGGATACAGTTATGAGCCACC
ACACCTGCCAAGTGCTTTGTGATACTATGCATTTGTTCAATGCAGATTGGGAAACTTAAAATTTGAATGGAGATTATGTTGATGGGCTTT
GGCAGTTCATTTGGATAGACTGGGATGAGAAGCTCTTGGGACTTGTGACTGGACAAAGCATTCCAGTATATTAAAATAAAATTAAGCCAT
ATTACTCCACTCATAAAAAGCAATCCTATGGTAGGTACATGGAGGTTGGGAATAGTGCACGGAAAGGTGGCAGCTTTCTTTGGCTTCATG
TTTTAATCTGGTAAAGTTCAAGATTGCACTTTAAGCAGGCCTCCTAAATATTTTAGATTTCTTGGGGATATGCTAAAATAAAACAACTAA

>In-frame_ENST00000428395_ENST00000464167_TCGA-85-8664-01A_FYTTD1_chr3_197503872_+_RPL35A_chr3_197680874_length(amino acids)=273AA_start in transcript=238_stop in transcript=1059
MEPSVIMGNDIIKLNRKEGKKQNFPRLNRRLLQQSGAQQFRMRVRWGIQQNSGFGKTSLNRRGRVMPGKRRPNGVITGLAARKTTGIRKG
ISPMNRPPLSDKNIEQYFPVLKRKANLLRQNEGQRKPVAVLKRPSQLSRKNNIPANFTRSGNKLNHQKDTRQATFLFRRGLKVQAQLNTE
QLLDDVVAKRTRQWRTSTTNGGILTVSIDNPGAVQCPVNTVTPGGKPNKTRVIWGKVTRAHGNSGMVRAKFRSNLPAKAIGHRIRVMLYP

--------------------------------------------------------------
>In-frame_ENST00000241502_ENST00000464167_TCGA-85-8664-01A_FYTTD1_chr3_197503872_+_RPL35A_chr3_197680874_length(transcript)=1959nt_BP=953nt
CGATCCTGCGAGGGCCGCTAGGAGCGAGTCACGGCGCGGGGCCGCTCTGGTCGCCCGCGAGTGTCGGTGGCCCCGCCCCGCCCGCAGCCG
CGGGTGGAGACCGAGGACGGCGCCGGCGCGTGCGCGCTCCCTCGGTGCGGCGGGCTGCGTGCGCGAGTGGGAGGTGGCAGGCCTGCGACT
CCGGCCTTGTCCGCGCCCGCTCTCGGCGCGACGTCTCCAGCCATGAACCGGTTTGGTACCCGGTTGGTGGGAGCCACGGCGACTTCTTCG
CCGCCGCCGAAGGCCCGCAGCAATGAAAACCTCGACAAAATAGATATGTCTTTGGATGATATCATCAAGTTGAATCGAAAGGAAGGGAAG
AAGCAGAATTTTCCAAGACTAAATAGAAGACTCCTCCAGCAAAGTGGTGCCCAGCAATTCAGGATGAGAGTGCGATGGGGAATCCAACAG
AATTCTGGTTTTGGTAAGACTAGTCTGAATCGTAGAGGAAGAGTAATGCCTGGAAAGAGACGTCCTAATGGAGTTATCACTGGCCTTGCA
GCTAGGAAAACGACTGGAATTCGAAAAGGAATTAGTCCTATGAATCGTCCACCTCTAAGTGACAAGAATATAGAACAATATTTTCCAGTG
TTAAAAAGGAAGGCAAACCTTCTGAGACAAAATGAAGGGCAGAGGAAACCAGTAGCAGTTCTCAAGAGACCTAGCCAGCTAAGCAGAAAA
AATAACATTCCAGCTAATTTTACCAGGAGTGGAAATAAATTAAATCATCAGAAAGATACTCGTCAGGCAACTTTTCTTTTCAGAAGAGGC
CTGAAGGTGCAGGCCCAGTTGAATACAGAACAACTGCTAGACGATGTAGTAGCAAAGAGAACTCGTCAATGGCGGACTTCCACCACAAAT
GGAGGGATTTTGACTGTATCTATTGACAATCCTGGAGCAGTGCAATGCCCAGTCAACACAGTCACTCCTGGCGGCAAACCAAACAAAACC
AGAGTCATCTGGGGAAAAGTAACTCGGGCCCATGGAAACAGTGGCATGGTTCGTGCCAAATTCCGAAGCAATCTTCCTGCTAAGGCCATT
GGACACAGAATCCGAGTGATGCTGTACCCCTCAAGGATTTAAACTAACGAAAAATCAATAAATAAATGTGGATTTGTGCTCTTGTATTTT
TAAGTGGATTAAAAAACTTACTACCTTAAATTGATTTGCTACATGCTTAAAATGATAGAGGTTGCTCAGCATTTTTGGAGTACAAGGGGG
TCAGAGAGACATGTGATGAAAATTACAGGGCGAGTACAGAGATTTAGAAGGGAACGGGTTTTAATGCGAGTATCTTTGACAGAGTCTTGC
TCTGTTGCCCATGCTGGAGTGTAGTGGTGCTCGCTGCAGCCTCACATTCAAAGGCTCAAGCAATCCTCCCTTGGCCTTTGAAGTAGCTGG
GACCACAGGCTCATGCCACCATCCCTGGGTCATTTTTAAATTTTTTGTAGAGAGGGTCTGACTCTTGCCTATGCTGGCTTCAAACTCCTG
GGCTCAAGCAATCCTCCTTCCTTGGCCTCTCCTGAAGTGCTGGGATACAGTTATGAGCCACCACACCTGCCAAGTGCTTTGTGATACTAT
GCATTTGTTCAATGCAGATTGGGAAACTTAAAATTTGAATGGAGATTATGTTGATGGGCTTTGGCAGTTCATTTGGATAGACTGGGATGA
GAAGCTCTTGGGACTTGTGACTGGACAAAGCATTCCAGTATATTAAAATAAAATTAAGCCATATTACTCCACTCATAAAAAGCAATCCTA
TGGTAGGTACATGGAGGTTGGGAATAGTGCACGGAAAGGTGGCAGCTTTCTTTGGCTTCATGTTTTAATCTGGTAAAGTTCAAGATTGCA

>In-frame_ENST00000241502_ENST00000464167_TCGA-85-8664-01A_FYTTD1_chr3_197503872_+_RPL35A_chr3_197680874_length(amino acids)=325AA_start in transcript=144_stop in transcript=1121
MRARVGGGRPATPALSAPALGATSPAMNRFGTRLVGATATSSPPPKARSNENLDKIDMSLDDIIKLNRKEGKKQNFPRLNRRLLQQSGAQ
QFRMRVRWGIQQNSGFGKTSLNRRGRVMPGKRRPNGVITGLAARKTTGIRKGISPMNRPPLSDKNIEQYFPVLKRKANLLRQNEGQRKPV
AVLKRPSQLSRKNNIPANFTRSGNKLNHQKDTRQATFLFRRGLKVQAQLNTEQLLDDVVAKRTRQWRTSTTNGGILTVSIDNPGAVQCPV

--------------------------------------------------------------
>In-frame_ENST00000424384_ENST00000464167_TCGA-85-8664-01A_FYTTD1_chr3_197503872_+_RPL35A_chr3_197680874_length(transcript)=2067nt_BP=1061nt
ACGGCTCGCCGCTCGCCGGCTCTTTGTGAGGAAAGATCTGCCGGTTTCCCCGGAGCGCGTTCGCGGTGGGCGTTATCGGGGAGCGAGGGG
AATGGTCCGACCGAGCCGTTCTCTCTGAAGAAAGGTCTTGGAGAGCCCGGCCGGGGCTGCGGTCGGTTAAACCAGCGCTTCCGGAGCTTT
CCCTGGTCGCCGGGCGTTCCAGGCCGGCGCCGGCCATGGCTGCCGGGCGCGACTCTCGGGGCCACCTCCGGCCGCGGCCCCGGAGCGTCT
GTCAGAAAGGAAGCAGCGCTCGGCCGCCTGTGGGATGTGGTTGTGTATTGAGCGCTGCCTAGAAAAGCACAGTCTCCCTCTCCAGGCCTC
AGAGCTAGCTAATGGGGGAGAAAGCAAACATCTTTGAAGGAGAGATGATTGCTGTGGCTCGCTGAGAAGCCAGATGATATCATCAAGTTG
AATCGAAAGGAAGGGAAGAAGCAGAATTTTCCAAGACTAAATAGAAGACTCCTCCAGCAAAGTGGTGCCCAGCAATTCAGGATGAGAGTG
CGATGGGGAATCCAACAGAATTCTGGTTTTGGTAAGACTAGTCTGAATCGTAGAGGAAGAGTAATGCCTGGAAAGAGACGTCCTAATGGA
GTTATCACTGGCCTTGCAGCTAGGAAAACGACTGGAATTCGAAAAGGAATTAGTCCTATGAATCGTCCACCTCTAAGTGACAAGAATATA
GAACAATATTTTCCAGTGTTAAAAAGGAAGGCAAACCTTCTGAGACAAAATGAAGGGCAGAGGAAACCAGTAGCAGTTCTCAAGAGACCT
AGCCAGCTAAGCAGAAAAAATAACATTCCAGCTAATTTTACCAGGAGTGGAAATAAATTAAATCATCAGAAAGATACTCGTCAGGCAACT
TTTCTTTTCAGAAGAGGCCTGAAGGTGCAGGCCCAGTTGAATACAGAACAACTGCTAGACGATGTAGTAGCAAAGAGAACTCGTCAATGG
CGGACTTCCACCACAAATGGAGGGATTTTGACTGTATCTATTGACAATCCTGGAGCAGTGCAATGCCCAGTCAACACAGTCACTCCTGGC
GGCAAACCAAACAAAACCAGAGTCATCTGGGGAAAAGTAACTCGGGCCCATGGAAACAGTGGCATGGTTCGTGCCAAATTCCGAAGCAAT
CTTCCTGCTAAGGCCATTGGACACAGAATCCGAGTGATGCTGTACCCCTCAAGGATTTAAACTAACGAAAAATCAATAAATAAATGTGGA
TTTGTGCTCTTGTATTTTTAAGTGGATTAAAAAACTTACTACCTTAAATTGATTTGCTACATGCTTAAAATGATAGAGGTTGCTCAGCAT
TTTTGGAGTACAAGGGGGTCAGAGAGACATGTGATGAAAATTACAGGGCGAGTACAGAGATTTAGAAGGGAACGGGTTTTAATGCGAGTA
TCTTTGACAGAGTCTTGCTCTGTTGCCCATGCTGGAGTGTAGTGGTGCTCGCTGCAGCCTCACATTCAAAGGCTCAAGCAATCCTCCCTT
GGCCTTTGAAGTAGCTGGGACCACAGGCTCATGCCACCATCCCTGGGTCATTTTTAAATTTTTTGTAGAGAGGGTCTGACTCTTGCCTAT
GCTGGCTTCAAACTCCTGGGCTCAAGCAATCCTCCTTCCTTGGCCTCTCCTGAAGTGCTGGGATACAGTTATGAGCCACCACACCTGCCA
AGTGCTTTGTGATACTATGCATTTGTTCAATGCAGATTGGGAAACTTAAAATTTGAATGGAGATTATGTTGATGGGCTTTGGCAGTTCAT
TTGGATAGACTGGGATGAGAAGCTCTTGGGACTTGTGACTGGACAAAGCATTCCAGTATATTAAAATAAAATTAAGCCATATTACTCCAC
TCATAAAAAGCAATCCTATGGTAGGTACATGGAGGTTGGGAATAGTGCACGGAAAGGTGGCAGCTTTCTTTGGCTTCATGTTTTAATCTG

>In-frame_ENST00000424384_ENST00000464167_TCGA-85-8664-01A_FYTTD1_chr3_197503872_+_RPL35A_chr3_197680874_length(amino acids)=273AA_start in transcript=408_stop in transcript=1229
MLWLAEKPDDIIKLNRKEGKKQNFPRLNRRLLQQSGAQQFRMRVRWGIQQNSGFGKTSLNRRGRVMPGKRRPNGVITGLAARKTTGIRKG
ISPMNRPPLSDKNIEQYFPVLKRKANLLRQNEGQRKPVAVLKRPSQLSRKNNIPANFTRSGNKLNHQKDTRQATFLFRRGLKVQAQLNTE
QLLDDVVAKRTRQWRTSTTNGGILTVSIDNPGAVQCPVNTVTPGGKPNKTRVIWGKVTRAHGNSGMVRAKFRSNLPAKAIGHRIRVMLYP

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Fusion Gene PPI Analysis for FYTTD1-RPL35A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for FYTTD1-RPL35A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for FYTTD1-RPL35A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	RPL35A	C1260899	Anemia, Diamond-Blackfan	2	GENOMICS_ENGLAND
Tgene	RPL35A	C2675859	Diamond-Blackfan Anemia 5	1	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	RPL35A	C4228778	Abnormality of radial ray	1	GENOMICS_ENGLAND