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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:G6PD-G6PD (FusionGDB2 ID:31903)

Fusion Gene Summary for G6PD-G6PD

check button Fusion gene summary
Fusion gene informationFusion gene name: G6PD-G6PD
Fusion gene ID: 31903
HgeneTgene
Gene symbol

G6PD

G6PD

Gene ID

8266

8266

Gene nameubiquitin like 4Aubiquitin like 4A
SynonymsDX254E|DXS254E|G6PD|GDX|GET5|MDY2|TMA24|UBL4DX254E|DXS254E|G6PD|GDX|GET5|MDY2|TMA24|UBL4
Cytomap

Xq28

Xq28

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-like protein 4Aubiquitin-like 4ubiquitin-like protein GDXubiquitin-like protein 4Aubiquitin-like 4ubiquitin-like protein GDX
Modification date2020031320200313
UniProtAcc.

P11413

Ensembl transtripts involved in fusion geneENST00000393562, ENST00000369620, 
ENST00000393564, ENST00000497281, 
ENST00000393562, ENST00000369620, 
ENST00000393564, ENST00000497281, 
Fusion gene scores* DoF score8 X 11 X 4=3524 X 7 X 2=56
# samples 128
** MAII scorelog2(12/352*10)=-1.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/56*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: G6PD [Title/Abstract] AND G6PD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointG6PD(153761181)-G6PD(153761805), # samples:1
G6PD(153759659)-G6PD(153760127), # samples:1
G6PD(153760922)-G6PD(153761161), # samples:1
G6PD(153759688)-G6PD(153759721), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneG6PD

GO:0071816

tail-anchored membrane protein insertion into ER membrane

25535373

TgeneG6PD

GO:0071816

tail-anchored membrane protein insertion into ER membrane

25535373


check buttonFusion gene breakpoints across G6PD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across G6PD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE816962G6PDchrX

153761181

-G6PDchrX

153761805

+
ChiTaRS5.0N/ABM688674G6PDchrX

153759659

+G6PDchrX

153760127

-
ChiTaRS5.0N/ABQ352059G6PDchrX

153760922

-G6PDchrX

153761161

+
ChiTaRS5.0N/AEC496429G6PDchrX

153759688

-G6PDchrX

153759721

+


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Fusion Gene ORF analysis for G6PD-G6PD

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000393562ENST00000393562G6PDchrX

153761181

-G6PDchrX

153761805

+
intron-3CDSENST00000393562ENST00000369620G6PDchrX

153761181

-G6PDchrX

153761805

+
intron-3CDSENST00000393562ENST00000393564G6PDchrX

153761181

-G6PDchrX

153761805

+
intron-intronENST00000393562ENST00000497281G6PDchrX

153761181

-G6PDchrX

153761805

+
intron-3CDSENST00000369620ENST00000393562G6PDchrX

153761181

-G6PDchrX

153761805

+
intron-3CDSENST00000369620ENST00000369620G6PDchrX

153761181

-G6PDchrX

153761805

+
intron-3CDSENST00000369620ENST00000393564G6PDchrX

153761181

-G6PDchrX

153761805

+
intron-intronENST00000369620ENST00000497281G6PDchrX

153761181

-G6PDchrX

153761805

+
intron-3CDSENST00000393564ENST00000393562G6PDchrX

153761181

-G6PDchrX

153761805

+
intron-3CDSENST00000393564ENST00000369620G6PDchrX

153761181

-G6PDchrX

153761805

+
intron-3CDSENST00000393564ENST00000393564G6PDchrX

153761181

-G6PDchrX

153761805

+
intron-intronENST00000393564ENST00000497281G6PDchrX

153761181

-G6PDchrX

153761805

+
intron-3CDSENST00000497281ENST00000393562G6PDchrX

153761181

-G6PDchrX

153761805

+
intron-3CDSENST00000497281ENST00000369620G6PDchrX

153761181

-G6PDchrX

153761805

+
intron-3CDSENST00000497281ENST00000393564G6PDchrX

153761181

-G6PDchrX

153761805

+
intron-intronENST00000497281ENST00000497281G6PDchrX

153761181

-G6PDchrX

153761805

+
intron-3UTRENST00000393562ENST00000393562G6PDchrX

153759659

+G6PDchrX

153760127

-
intron-intronENST00000393562ENST00000369620G6PDchrX

153759659

+G6PDchrX

153760127

-
intron-intronENST00000393562ENST00000393564G6PDchrX

153759659

+G6PDchrX

153760127

-
intron-intronENST00000393562ENST00000497281G6PDchrX

153759659

+G6PDchrX

153760127

-
intron-3UTRENST00000369620ENST00000393562G6PDchrX

153759659

+G6PDchrX

153760127

-
intron-intronENST00000369620ENST00000369620G6PDchrX

153759659

+G6PDchrX

153760127

-
intron-intronENST00000369620ENST00000393564G6PDchrX

153759659

+G6PDchrX

153760127

-
intron-intronENST00000369620ENST00000497281G6PDchrX

153759659

+G6PDchrX

153760127

-
intron-3UTRENST00000393564ENST00000393562G6PDchrX

153759659

+G6PDchrX

153760127

-
intron-intronENST00000393564ENST00000369620G6PDchrX

153759659

+G6PDchrX

153760127

-
intron-intronENST00000393564ENST00000393564G6PDchrX

153759659

+G6PDchrX

153760127

-
intron-intronENST00000393564ENST00000497281G6PDchrX

153759659

+G6PDchrX

153760127

-
intron-3UTRENST00000497281ENST00000393562G6PDchrX

153759659

+G6PDchrX

153760127

-
intron-intronENST00000497281ENST00000369620G6PDchrX

153759659

+G6PDchrX

153760127

-
intron-intronENST00000497281ENST00000393564G6PDchrX

153759659

+G6PDchrX

153760127

-
intron-intronENST00000497281ENST00000497281G6PDchrX

153759659

+G6PDchrX

153760127

-
intron-intronENST00000393562ENST00000393562G6PDchrX

153760922

-G6PDchrX

153761161

+
intron-intronENST00000393562ENST00000369620G6PDchrX

153760922

-G6PDchrX

153761161

+
intron-intronENST00000393562ENST00000393564G6PDchrX

153760922

-G6PDchrX

153761161

+
intron-intronENST00000393562ENST00000497281G6PDchrX

153760922

-G6PDchrX

153761161

+
intron-intronENST00000369620ENST00000393562G6PDchrX

153760922

-G6PDchrX

153761161

+
intron-intronENST00000369620ENST00000369620G6PDchrX

153760922

-G6PDchrX

153761161

+
intron-intronENST00000369620ENST00000393564G6PDchrX

153760922

-G6PDchrX

153761161

+
intron-intronENST00000369620ENST00000497281G6PDchrX

153760922

-G6PDchrX

153761161

+
intron-intronENST00000393564ENST00000393562G6PDchrX

153760922

-G6PDchrX

153761161

+
intron-intronENST00000393564ENST00000369620G6PDchrX

153760922

-G6PDchrX

153761161

+
intron-intronENST00000393564ENST00000393564G6PDchrX

153760922

-G6PDchrX

153761161

+
intron-intronENST00000393564ENST00000497281G6PDchrX

153760922

-G6PDchrX

153761161

+
intron-intronENST00000497281ENST00000393562G6PDchrX

153760922

-G6PDchrX

153761161

+
intron-intronENST00000497281ENST00000369620G6PDchrX

153760922

-G6PDchrX

153761161

+
intron-intronENST00000497281ENST00000393564G6PDchrX

153760922

-G6PDchrX

153761161

+
intron-intronENST00000497281ENST00000497281G6PDchrX

153760922

-G6PDchrX

153761161

+
intron-3UTRENST00000393562ENST00000393562G6PDchrX

153759688

-G6PDchrX

153759721

+
intron-intronENST00000393562ENST00000369620G6PDchrX

153759688

-G6PDchrX

153759721

+
intron-intronENST00000393562ENST00000393564G6PDchrX

153759688

-G6PDchrX

153759721

+
intron-intronENST00000393562ENST00000497281G6PDchrX

153759688

-G6PDchrX

153759721

+
intron-3UTRENST00000369620ENST00000393562G6PDchrX

153759688

-G6PDchrX

153759721

+
intron-intronENST00000369620ENST00000369620G6PDchrX

153759688

-G6PDchrX

153759721

+
intron-intronENST00000369620ENST00000393564G6PDchrX

153759688

-G6PDchrX

153759721

+
intron-intronENST00000369620ENST00000497281G6PDchrX

153759688

-G6PDchrX

153759721

+
intron-3UTRENST00000393564ENST00000393562G6PDchrX

153759688

-G6PDchrX

153759721

+
intron-intronENST00000393564ENST00000369620G6PDchrX

153759688

-G6PDchrX

153759721

+
intron-intronENST00000393564ENST00000393564G6PDchrX

153759688

-G6PDchrX

153759721

+
intron-intronENST00000393564ENST00000497281G6PDchrX

153759688

-G6PDchrX

153759721

+
intron-3UTRENST00000497281ENST00000393562G6PDchrX

153759688

-G6PDchrX

153759721

+
intron-intronENST00000497281ENST00000369620G6PDchrX

153759688

-G6PDchrX

153759721

+
intron-intronENST00000497281ENST00000393564G6PDchrX

153759688

-G6PDchrX

153759721

+
intron-intronENST00000497281ENST00000497281G6PDchrX

153759688

-G6PDchrX

153759721

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for G6PD-G6PD


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for G6PD-G6PD


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.G6PD

P11413

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. {ECO:0000269|PubMed:15858258, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:26479991, ECO:0000269|PubMed:743300}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for G6PD-G6PD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for G6PD-G6PD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for G6PD-G6PD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneG6PDP11413DB03085Glycolic acidInhibitorSmall moleculeApproved|Investigational

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Related Diseases for G6PD-G6PD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneG6PDC2720289ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY21CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneG6PDC0005586Bipolar Disorder5PSYGENET
HgeneG6PDC0002878Anemia, Hemolytic4CTD_human;GENOMICS_ENGLAND
HgeneG6PDC0002879Anemia, Hemolytic, Acquired3CTD_human
HgeneG6PDC0002889Anemia, Microangiopathic3CTD_human
HgeneG6PDC0022660Kidney Failure, Acute3CTD_human
HgeneG6PDC0221021Microangiopathic hemolytic anemia3CTD_human
HgeneG6PDC1565662Acute Kidney Insufficiency3CTD_human
HgeneG6PDC2609414Acute kidney injury3CTD_human
HgeneG6PDC2939465Deficiency of glucose-6-phosphate dehydrogenase3CTD_human
HgeneG6PDC0002882Anemia, Hemolytic, Congenital Nonspherocytic2CTD_human
HgeneG6PDC0015702Favism2CTD_human
HgeneG6PDC0019054Hemolysis (disorder)2CTD_human
HgeneG6PDC0235574Intravascular hemolysis2CTD_human
HgeneG6PDC0312854Extravascular Hemolysis2CTD_human
HgeneG6PDC0520572Enzymopathy2GENOMICS_ENGLAND
HgeneG6PDC0011616Contact Dermatitis1CTD_human
HgeneG6PDC0018203Chronic granulomatous disease1CTD_human
HgeneG6PDC0031306Phagocyte Bactericidal Dysfunction1CTD_human
HgeneG6PDC0162351Contact hypersensitivity1CTD_human
HgeneG6PDC1844376Granulomatous Disease, Chronic, X-Linked1CTD_human
HgeneG6PDC3661525Autosomal Recessive Chronic Granulomatous Disease1CTD_human
HgeneG6PDC3714514Infection1GENOMICS_ENGLAND
TgeneG6PDC2720289ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY21CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneG6PDC0005586Bipolar Disorder5PSYGENET
TgeneG6PDC0002878Anemia, Hemolytic4CTD_human;GENOMICS_ENGLAND
TgeneG6PDC0002879Anemia, Hemolytic, Acquired3CTD_human
TgeneG6PDC0002889Anemia, Microangiopathic3CTD_human
TgeneG6PDC0022660Kidney Failure, Acute3CTD_human
TgeneG6PDC0221021Microangiopathic hemolytic anemia3CTD_human
TgeneG6PDC1565662Acute Kidney Insufficiency3CTD_human
TgeneG6PDC2609414Acute kidney injury3CTD_human
TgeneG6PDC2939465Deficiency of glucose-6-phosphate dehydrogenase3CTD_human
TgeneG6PDC0002882Anemia, Hemolytic, Congenital Nonspherocytic2CTD_human
TgeneG6PDC0015702Favism2CTD_human
TgeneG6PDC0019054Hemolysis (disorder)2CTD_human
TgeneG6PDC0235574Intravascular hemolysis2CTD_human
TgeneG6PDC0312854Extravascular Hemolysis2CTD_human
TgeneG6PDC0520572Enzymopathy2GENOMICS_ENGLAND
TgeneG6PDC0011616Contact Dermatitis1CTD_human
TgeneG6PDC0018203Chronic granulomatous disease1CTD_human
TgeneG6PDC0031306Phagocyte Bactericidal Dysfunction1CTD_human
TgeneG6PDC0162351Contact hypersensitivity1CTD_human
TgeneG6PDC1844376Granulomatous Disease, Chronic, X-Linked1CTD_human
TgeneG6PDC3661525Autosomal Recessive Chronic Granulomatous Disease1CTD_human
TgeneG6PDC3714514Infection1GENOMICS_ENGLAND