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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GALNT7-SPCS3 (FusionGDB2 ID:32197)

Fusion Gene Summary for GALNT7-SPCS3

Fusion gene summary

Fusion gene information	Fusion gene name: GALNT7-SPCS3
	Fusion gene ID: 32197
		Hgene	Tgene
	Gene symbol	GALNT7	SPCS3
	Gene ID	117248	60559
	Gene name	polypeptide N-acetylgalactosaminyltransferase 15	signal peptidase complex subunit 3
	Synonyms	GALNACT15\|GALNT13\|GALNT7\|GALNTL2\|PIH5\|pp-GalNAc-T15	PRO3567\|SPC22/23\|SPC3\|YLR066W
	Cytomap	3p25.1	4q34.2
	Type of gene	protein-coding	protein-coding
	Description	polypeptide N-acetylgalactosaminyltransferase 15UDP-GalNAc transferase T15UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15UDP-N-acetyl-alpha-D-ga	signal peptidase complex subunit 3SPase 22 kDa subunitSPase 22/23 kDa subunitmicrosomal signal peptidase 22/23 kDa subunitmicrosomal signal peptidase 23 kDa subunitsignal peptidase complex subunit 3 homolog
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000265000, ENST00000512285, ENST00000502407,	ENST00000503362, ENST00000507001,
Fusion gene scores	* DoF score	8 X 6 X 5=240	4 X 2 X 2=16
	# samples	11	4
	** MAII score	log2(11/240*10)=-1.12553088208386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: GALNT7 [Title/Abstract] AND SPCS3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GALNT7(174169591)-SPCS3(177243321), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SPCS3	GO:0006508	proteolysis	27499293

Fusion gene breakpoints across GALNT7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SPCS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-EJ-7123-01A	GALNT7	chr4	174169591	+	SPCS3	chr4	177243321	+
ChimerDB4	PRAD	TCGA-EJ-7123-01A	GALNT7	chr4	174169591	-	SPCS3	chr4	177243321	+

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Fusion Gene ORF analysis for GALNT7-SPCS3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000265000	ENST00000503362	GALNT7	chr4	174169591	+	SPCS3	chr4	177243321	+
5CDS-intron	ENST00000265000	ENST00000507001	GALNT7	chr4	174169591	+	SPCS3	chr4	177243321	+
In-frame	ENST00000512285	ENST00000503362	GALNT7	chr4	174169591	+	SPCS3	chr4	177243321	+
5CDS-intron	ENST00000512285	ENST00000507001	GALNT7	chr4	174169591	+	SPCS3	chr4	177243321	+
intron-3CDS	ENST00000502407	ENST00000503362	GALNT7	chr4	174169591	+	SPCS3	chr4	177243321	+
intron-intron	ENST00000502407	ENST00000507001	GALNT7	chr4	174169591	+	SPCS3	chr4	177243321	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000265000

GALNT7

chr4

174169591

ENST00000503362

SPCS3

chr4

177243321

4985

670

1069

328

ENST00000512285

GALNT7

chr4

174169591

ENST00000503362

SPCS3

chr4

177243321

4927

612

1011

328

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000265000	ENST00000503362	GALNT7	chr4	174169591	+	SPCS3	chr4	177243321	+	8.25E-05	0.9999175
ENST00000512285	ENST00000503362	GALNT7	chr4	174169591	+	SPCS3	chr4	177243321	+	7.98E-05	0.99992025

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Fusion Genomic Features for GALNT7-SPCS3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GALNT7	chr4	174169591	+	SPCS3	chr4	177243320	+	0.010228447	0.98977154
GALNT7	chr4	174169591	+	SPCS3	chr4	177243320	+	0.010228447	0.98977154

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GALNT7-SPCS3

Go to
FGviewer for the breakpoints of chr4:174169591-chr4:177243321
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GALNT7

chr4:174169591

chr4:177243321

ENST00000265000

1_6

195.66666666666666

658.0

Topological domain

Cytoplasmic

Hgene

GALNT7

chr4:174169591

chr4:177243321

ENST00000265000

7_29

195.66666666666666

658.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GALNT7

chr4:174169591

chr4:177243321

ENST00000265000

532_652

195.66666666666666

658.0

Domain

Ricin B-type lectin

Hgene

GALNT7

chr4:174169591

chr4:177243321

ENST00000265000

206_317

195.66666666666666

658.0

Region

Note=Catalytic subdomain A

Hgene

GALNT7

chr4:174169591

chr4:177243321

ENST00000265000

381_443

195.66666666666666

658.0

Region

Note=Catalytic subdomain B

Hgene

GALNT7

chr4:174169591

chr4:177243321

ENST00000265000

30_657

195.66666666666666

658.0

Topological domain

Lumenal

Tgene

SPCS3

chr4:174169591

chr4:177243321

ENST00000503362

1_11

47.666666666666664

181.0

Topological domain

Cytoplasmic

Tgene

SPCS3

chr4:174169591

chr4:177243321

ENST00000503362

33_180

47.666666666666664

181.0

Topological domain

Lumenal

Tgene

SPCS3

chr4:174169591

chr4:177243321

ENST00000503362

12_32

47.666666666666664

181.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Gene Sequence for GALNT7-SPCS3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000265000_ENST00000503362_TCGA-EJ-7123-01A_GALNT7_chr4_174169591_+_SPCS3_chr4_177243321_length(transcript)=4985nt_BP=670nt
AGAGCCGGAGGAGGGGGAAGGAGGGAGGGGAGAGCGGTGGCGGCGGCTGCGCCGGGCTGTGAGTCTCTCGCCGCCGGAGGAAGATGAGGC
TGAAGATTGGGTTCATCTTACGCAGTTTGCTGGTGGTGGGAAGCTTCCTGGGGCTAGTGGTCCTCTGGTCTTCCCTGACCCCGCGGCCGG
ACGACCCAAGCCCGCTGAGCAGGATGAGGGAAGACAGAGATGTCAATGACCCCATGCCCAACCGAGGCGGCAATGGACTAGCTCCTGGGG
AGGACAGATTCAAACCTGTGGTACCATGGCCTCATGTTGAAGGAGTAGAAGTGGACTTAGAGTCTATTAGAAGAATAAACAAGGCCAAAA
ATGAACAAGAGCACCATGCTGGAGGAGATTCCCAGAAAGATATCATGCAGAGGCAGTATCTCACATTTAAGCCTCAGACATTCACCTACC
ATGATCCTGTGCTTCGCCCAGGGATCCTCGGTAACTTTGAACCCAAAGAACCTGAGCCTCCTGGAGTGGTTGGTGGCCCTGGAGAGAAAG
CCAAGCCATTGGTTTTGGGACCAGAATTCAAACAAGCAATTCAAGCCAGCATTAAAGAGTTTGGATTTAACATGGTGGCAAGTGACATGA
TCTCACTGGACCGCAGCGTCAATGACTTACGCCAAGAAGAAAAAAATGTAGAAGATTTCACTGGACCTAGAGAAAGAAGTGATCTGGGAT
TTATCACATTTGATATAACTGCTGATCTAGAGAATATATTTGATTGGAATGTTAAGCAGTTGTTTCTTTATTTATCAGCAGAATATTCAA
CAAAAAATAATGCTCTGAACCAAGTTGTCCTATGGGACAAGATTGTTTTGAGAGGTGATAATCCGAAGCTGCTGCTGAAAGATATGAAAA
CAAAATATTTTTTCTTTGACGATGGAAATGGTCTCAAGGGAAACAGGAATGTCACTTTGACCCTGTCTTGGAACGTCGTACCAAATGCTG
GAATTCTACCTCTTGTGACAGGATCAGGACACGTATCTGTCCCATTTCCAGATACATATGAAATAACGAAGAGTTATTAAATTATTCTGA
ATTTGAAACAACATATTTTTATACTTAATGAATTGTATCTCATTAATCTCTTCCCTTACATCTTCATGTATTGTTGGTTTGTTTTTTGGT
TTTGGGTTTTTTTTTTTTTTTTTTTGGTATAAGAACTAACATCAAAAGGCCTGTTTAAAGGGAAAGGTTAATGGGCTACTTAATATTATG
AACAAAACAAAAAAACAAGGCTGCCACAGTGGAATATTATCTTACAAGAATAAGAACTACATAAAACAGATTTGTAAAAAATACATATTT
GAAGTATTCCCTGTATTTCCATTATTCTTTATGGAATATAAAGTAAGCATGAAAGGTAGTTAAAACTTTCAGGTGCCTGTAGAGTCATAA
TAACTGTATTTTATGCCTTGCATTCACGCAAATTCACATTGGATGTGATTTAAAAGTAGACATTCTCTTTTTCCTCTTTTAGGATATGTT
TGATTACTGGAAAATTAATATGGTTATTTGTTAGAAGTCTGGTTTATAAAAAAGCCAAAAGTGATGGAATTTATTCCATTTGTCTTAGGA
AGGCCCATAATACTTGTTTTTCTTACATGTGACTAGCAACTTTCTCCACTTAAAGACTAAATACCTCTTTATATGATGTAAATTATTCTA
ATTCATTTTAAAATCTTTTAGGTCAGCAAAATGTGTGTCTTCAGTGCTTTCTCTAAAAACGTTCCTTTATAGCTTTGTACTTTTTTTTTT
AGCGTTGCCATTGAAAGTTAAAATGTTTGCATGGTTTACCCTCTGAGTTATGTTTCTTCTAGTGAGCATGCCTGCTGTCACTAAGTGAAT
TATTTACTACTTTTTGTAGGTCTATATTTTAATAATTATTGGGATAATAATAATTGTGGTATGCTTTCCATTTACAAACCACTCATATAC
TTTAGTGTATGTCATCCTCAATAATCTAATGAGGTAAGTAGTATAAGTGTTAGCTCTTTGCAGATAAGAAACTGAAACCCAGAAGTTTAT
TGAATTGCTTCATTGTTACCTAGCCAGCAAGGAGTGGAATTAAAACTTGAACTCAGATCTTCTAATTTTCTGAGCTCATCCTTTCTCTTA
TACCTCAGATTGCAGACTAATCAAATTTTACTTAAAACCTTCCTGATATTTTTGTTACCCTGGACACCCTTTCTATTCTAGAAAAGGTTT
CCCATTTTATATGGAAGTGACTAATTTTCAAGCTGCCAACAACTTATATCGAGGTAATATTTTATTCTCTGAATAAATTCATTTCACTTA
TATTAAAAGCATAAGGAAATCTACATGTATGTAAAAATAACTTAGAAATTCAGTACATAATACATGATTGAATACATGATCGTATTTAAC
ATGTTTTTTTTTTCTGCAGTGGACAAATAAACATCCTCAAAGTAGCAACTGCAAATCAGTTACCCTTAGAAAAGCAAGACCAAACACTGT
AGTTACACTATTAGCAGTGACCAAAAAGGGCTAATATTTTCTAAGAATAGTTTAAATTACAGACATTTGTTATATTTACCTTATGTGAAA
TACATCACTATTTAATTACATTAATTTTAACATCTGTTGTGTGGAGTTGTATAGTTCATGCAAAAGCCTGTGGGTATGGGTTTTTCAAAC
CAGCAGAAAGGTCAAAGGTACCTGAATGCTAAACTGCCTGGCTCCCAGCTTTTTCATTAAACTTTTCAGGGTCTTGGTTTCTTTATCTGT
AAAATGACAGAGTTGGACCAGTTAACTTTAATGGCCATCCTTTTACACCACACAAGTTGATAAAATTTATCTGTTCAGCAAAGAGATTGA
ACAAAAAAGCACGTTAGTAATATGAAGACAGGAAAACGAATGAAAGTCTAACACATAACTCATATTGATTTACTTTATTTCTGTTAGATT
TTACACTCTGAAAATTTCACCTCATTTAGTTTGTACAAATACTAGACATGGAAACTTAAAATGTGCAGGTGTCAAAGCTTAAAAATCAGG
TGTGTCCTCTTTAAAGGCATGTGCGATAAGCCTGCAGTCTTAACCAGACCTGGTACCAGTTTAACAGTTCATGATACTTCTGTGATGAGT
GGATCTGTTAGTCTGGTAGAGATTAATGTTGAAATTTACTTGAATTACAGTTATTTGACAAGCCCACTTTTTTTGGAGTTTGGTGAGGAA
GATAAGTAAAAATGCCCAACTAGTACAATGTGGAGAAAGTTTTCTGTTTGCTTGACTAAGGGAAATTGCTCAGAAAAAGAATGCTCCAAC
ATGGGAATAAGGACCTTCAGTCTCAGGAACTCATTTTTGGGTGCAGTTTCTACATTTAAAAAATTGACTTGTGTTCAGTTTGATAACCAG
TTCATTTGCTTTAGTCTCAGTGTTTTAAAGAAGTCTCATAATGTTCTACAAAGACACAAAGCTTCAGGCTTATACAAAACTGAGTATGAT
TAGAAATACCTGAGCCCAGAAATGATTCTGAGAAAAGAGAATAATTTGAAGACACTTATTTAAAAGTAATTATGGTTAGAAATGAATTAA
TTTAAAAATGTGTTCACATATCCCTTTCTCTAACAGTTTAACCTAGACAAACATCTGTATCAGTATTTTTTTATTCCCCTGATTGATTAC
ATTTGGTTTCTTTATTCTGAAAGGAAAATAACAAAAACTTCAGAAATTCCTAAGGGTGTAATAAGAAAGTGGGTTTTGAGTTTCCTTTCC
TGGAATTATTTTACAGTTCTTTGGTGGGTCTCGTCAGCCAATTCATAGCTGGGCTTTAAGATTATCATCTTAGAGATGATAGATGGGCTT
TTTAAAGATTTCATCTTAGAGATGAAAAGCTGGGCTTTTTCTCTAAGATGATAATCTTAAAGCCCAGCTATTAATTGATAATGAACATTT
TTCACTATTTTTTTTTCTATCTGAAGCTTAGAGATCTAGAGCTTTGGATCTTTCGGGTATATGTCAATGGAGGTATTATTTTATAATACT
TTGCATTGACATGAAGTGGGTTCATGGGGGAAAACCATGAGCTGTGAACATTGGTAGCAAACAAGCATATATTCATTTCAAAACTTTCCT
TGCTTTTAGCAGAGAGAAGCCTGTATATGTTACATGTGTGACTTTCAGTAGTTTAAAGAGATGTTTCAAAAAATTGTTGCATGTTTTTGA
TGCAATTTGGGAAATTGTTTACTTCACAATGTAGTCATTCATAAAAAAATTCATGAAAATACTGAACATATGTTTGAGGATTTTTCTTTT
CCTTTTTAAATTTTTTTATTTTTTCTGAGACGGAGATCTGCTCTTACGCCCAGGCTAGAGTGAAGTGGCGCGATCTTGGCTTACTGCAAC
CTCCACCCCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGATTACAGGCGCCCGCCACCACGTCCGGCTAATTTTT
GTATTTTCAGTAGAGACGGGGTTTTGCTATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGTGATCCACCTGCCTCGGCCTCCCAA
AGTGTTAGGATAACAGGTGTGAGCCACCGTGCCCGGCTGAAGATTTTTCTTAATTGCAATAAATATTCAGCATTTTTTCTAATGAAAATG
AATTTTGTTTACCAGTAAAAGTATGCATTTTAAAAGACTTTCAGATTTATGCTTTTTACGTGAAGCTGCTAAACTAAAAGTAAATGGAAG
AAACCAAGTCTAGTAGGTTTTTTCTTTTTTTTTGTGGGGGTGGGATGGGGGAGGTTAGTTACACTTAAAATATCTTCTCCAGAGACTGTA
TGCTCCTATACTAGACTGTAAGCTCTTTGAGGGCAGTCTGTCAGATTTATCTTTGTATCTTCCCCAGCGCCTAGTGTAGTGCCTTGCACA

>In-frame_ENST00000265000_ENST00000503362_TCGA-EJ-7123-01A_GALNT7_chr4_174169591_+_SPCS3_chr4_177243321_length(amino acids)=328AA_start in transcript=83_stop in transcript=1069
MRLKIGFILRSLLVVGSFLGLVVLWSSLTPRPDDPSPLSRMREDRDVNDPMPNRGGNGLAPGEDRFKPVVPWPHVEGVEVDLESIRRINK
AKNEQEHHAGGDSQKDIMQRQYLTFKPQTFTYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLGPEFKQAIQASIKEFGFNMVAS
DMISLDRSVNDLRQEEKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKD

--------------------------------------------------------------
>In-frame_ENST00000512285_ENST00000503362_TCGA-EJ-7123-01A_GALNT7_chr4_174169591_+_SPCS3_chr4_177243321_length(transcript)=4927nt_BP=612nt
GTGAGTCTCTCGCCGCCGGAGGAAGATGAGGCTGAAGATTGGGTTCATCTTACGCAGTTTGCTGGTGGTGGGAAGCTTCCTGGGGCTAGT
GGTCCTCTGGTCTTCCCTGACCCCGCGGCCGGACGACCCAAGCCCGCTGAGCAGGATGAGGGAAGACAGAGATGTCAATGACCCCATGCC
CAACCGAGGCGGCAATGGACTAGCTCCTGGGGAGGACAGATTCAAACCTGTGGTACCATGGCCTCATGTTGAAGGAGTAGAAGTGGACTT
AGAGTCTATTAGAAGAATAAACAAGGCCAAAAATGAACAAGAGCACCATGCTGGAGGAGATTCCCAGAAAGATATCATGCAGAGGCAGTA
TCTCACATTTAAGCCTCAGACATTCACCTACCATGATCCTGTGCTTCGCCCAGGGATCCTCGGTAACTTTGAACCCAAAGAACCTGAGCC
TCCTGGAGTGGTTGGTGGCCCTGGAGAGAAAGCCAAGCCATTGGTTTTGGGACCAGAATTCAAACAAGCAATTCAAGCCAGCATTAAAGA
GTTTGGATTTAACATGGTGGCAAGTGACATGATCTCACTGGACCGCAGCGTCAATGACTTACGCCAAGAAGAAAAAAATGTAGAAGATTT
CACTGGACCTAGAGAAAGAAGTGATCTGGGATTTATCACATTTGATATAACTGCTGATCTAGAGAATATATTTGATTGGAATGTTAAGCA
GTTGTTTCTTTATTTATCAGCAGAATATTCAACAAAAAATAATGCTCTGAACCAAGTTGTCCTATGGGACAAGATTGTTTTGAGAGGTGA
TAATCCGAAGCTGCTGCTGAAAGATATGAAAACAAAATATTTTTTCTTTGACGATGGAAATGGTCTCAAGGGAAACAGGAATGTCACTTT
GACCCTGTCTTGGAACGTCGTACCAAATGCTGGAATTCTACCTCTTGTGACAGGATCAGGACACGTATCTGTCCCATTTCCAGATACATA
TGAAATAACGAAGAGTTATTAAATTATTCTGAATTTGAAACAACATATTTTTATACTTAATGAATTGTATCTCATTAATCTCTTCCCTTA
CATCTTCATGTATTGTTGGTTTGTTTTTTGGTTTTGGGTTTTTTTTTTTTTTTTTTTGGTATAAGAACTAACATCAAAAGGCCTGTTTAA
AGGGAAAGGTTAATGGGCTACTTAATATTATGAACAAAACAAAAAAACAAGGCTGCCACAGTGGAATATTATCTTACAAGAATAAGAACT
ACATAAAACAGATTTGTAAAAAATACATATTTGAAGTATTCCCTGTATTTCCATTATTCTTTATGGAATATAAAGTAAGCATGAAAGGTA
GTTAAAACTTTCAGGTGCCTGTAGAGTCATAATAACTGTATTTTATGCCTTGCATTCACGCAAATTCACATTGGATGTGATTTAAAAGTA
GACATTCTCTTTTTCCTCTTTTAGGATATGTTTGATTACTGGAAAATTAATATGGTTATTTGTTAGAAGTCTGGTTTATAAAAAAGCCAA
AAGTGATGGAATTTATTCCATTTGTCTTAGGAAGGCCCATAATACTTGTTTTTCTTACATGTGACTAGCAACTTTCTCCACTTAAAGACT
AAATACCTCTTTATATGATGTAAATTATTCTAATTCATTTTAAAATCTTTTAGGTCAGCAAAATGTGTGTCTTCAGTGCTTTCTCTAAAA
ACGTTCCTTTATAGCTTTGTACTTTTTTTTTTAGCGTTGCCATTGAAAGTTAAAATGTTTGCATGGTTTACCCTCTGAGTTATGTTTCTT
CTAGTGAGCATGCCTGCTGTCACTAAGTGAATTATTTACTACTTTTTGTAGGTCTATATTTTAATAATTATTGGGATAATAATAATTGTG
GTATGCTTTCCATTTACAAACCACTCATATACTTTAGTGTATGTCATCCTCAATAATCTAATGAGGTAAGTAGTATAAGTGTTAGCTCTT
TGCAGATAAGAAACTGAAACCCAGAAGTTTATTGAATTGCTTCATTGTTACCTAGCCAGCAAGGAGTGGAATTAAAACTTGAACTCAGAT
CTTCTAATTTTCTGAGCTCATCCTTTCTCTTATACCTCAGATTGCAGACTAATCAAATTTTACTTAAAACCTTCCTGATATTTTTGTTAC
CCTGGACACCCTTTCTATTCTAGAAAAGGTTTCCCATTTTATATGGAAGTGACTAATTTTCAAGCTGCCAACAACTTATATCGAGGTAAT
ATTTTATTCTCTGAATAAATTCATTTCACTTATATTAAAAGCATAAGGAAATCTACATGTATGTAAAAATAACTTAGAAATTCAGTACAT
AATACATGATTGAATACATGATCGTATTTAACATGTTTTTTTTTTCTGCAGTGGACAAATAAACATCCTCAAAGTAGCAACTGCAAATCA
GTTACCCTTAGAAAAGCAAGACCAAACACTGTAGTTACACTATTAGCAGTGACCAAAAAGGGCTAATATTTTCTAAGAATAGTTTAAATT
ACAGACATTTGTTATATTTACCTTATGTGAAATACATCACTATTTAATTACATTAATTTTAACATCTGTTGTGTGGAGTTGTATAGTTCA
TGCAAAAGCCTGTGGGTATGGGTTTTTCAAACCAGCAGAAAGGTCAAAGGTACCTGAATGCTAAACTGCCTGGCTCCCAGCTTTTTCATT
AAACTTTTCAGGGTCTTGGTTTCTTTATCTGTAAAATGACAGAGTTGGACCAGTTAACTTTAATGGCCATCCTTTTACACCACACAAGTT
GATAAAATTTATCTGTTCAGCAAAGAGATTGAACAAAAAAGCACGTTAGTAATATGAAGACAGGAAAACGAATGAAAGTCTAACACATAA
CTCATATTGATTTACTTTATTTCTGTTAGATTTTACACTCTGAAAATTTCACCTCATTTAGTTTGTACAAATACTAGACATGGAAACTTA
AAATGTGCAGGTGTCAAAGCTTAAAAATCAGGTGTGTCCTCTTTAAAGGCATGTGCGATAAGCCTGCAGTCTTAACCAGACCTGGTACCA
GTTTAACAGTTCATGATACTTCTGTGATGAGTGGATCTGTTAGTCTGGTAGAGATTAATGTTGAAATTTACTTGAATTACAGTTATTTGA
CAAGCCCACTTTTTTTGGAGTTTGGTGAGGAAGATAAGTAAAAATGCCCAACTAGTACAATGTGGAGAAAGTTTTCTGTTTGCTTGACTA
AGGGAAATTGCTCAGAAAAAGAATGCTCCAACATGGGAATAAGGACCTTCAGTCTCAGGAACTCATTTTTGGGTGCAGTTTCTACATTTA
AAAAATTGACTTGTGTTCAGTTTGATAACCAGTTCATTTGCTTTAGTCTCAGTGTTTTAAAGAAGTCTCATAATGTTCTACAAAGACACA
AAGCTTCAGGCTTATACAAAACTGAGTATGATTAGAAATACCTGAGCCCAGAAATGATTCTGAGAAAAGAGAATAATTTGAAGACACTTA
TTTAAAAGTAATTATGGTTAGAAATGAATTAATTTAAAAATGTGTTCACATATCCCTTTCTCTAACAGTTTAACCTAGACAAACATCTGT
ATCAGTATTTTTTTATTCCCCTGATTGATTACATTTGGTTTCTTTATTCTGAAAGGAAAATAACAAAAACTTCAGAAATTCCTAAGGGTG
TAATAAGAAAGTGGGTTTTGAGTTTCCTTTCCTGGAATTATTTTACAGTTCTTTGGTGGGTCTCGTCAGCCAATTCATAGCTGGGCTTTA
AGATTATCATCTTAGAGATGATAGATGGGCTTTTTAAAGATTTCATCTTAGAGATGAAAAGCTGGGCTTTTTCTCTAAGATGATAATCTT
AAAGCCCAGCTATTAATTGATAATGAACATTTTTCACTATTTTTTTTTCTATCTGAAGCTTAGAGATCTAGAGCTTTGGATCTTTCGGGT
ATATGTCAATGGAGGTATTATTTTATAATACTTTGCATTGACATGAAGTGGGTTCATGGGGGAAAACCATGAGCTGTGAACATTGGTAGC
AAACAAGCATATATTCATTTCAAAACTTTCCTTGCTTTTAGCAGAGAGAAGCCTGTATATGTTACATGTGTGACTTTCAGTAGTTTAAAG
AGATGTTTCAAAAAATTGTTGCATGTTTTTGATGCAATTTGGGAAATTGTTTACTTCACAATGTAGTCATTCATAAAAAAATTCATGAAA
ATACTGAACATATGTTTGAGGATTTTTCTTTTCCTTTTTAAATTTTTTTATTTTTTCTGAGACGGAGATCTGCTCTTACGCCCAGGCTAG
AGTGAAGTGGCGCGATCTTGGCTTACTGCAACCTCCACCCCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGATTA
CAGGCGCCCGCCACCACGTCCGGCTAATTTTTGTATTTTCAGTAGAGACGGGGTTTTGCTATGTTGGCCAGGCTGGTCTCAAACTCCTGA
CCTCAAGTGATCCACCTGCCTCGGCCTCCCAAAGTGTTAGGATAACAGGTGTGAGCCACCGTGCCCGGCTGAAGATTTTTCTTAATTGCA
ATAAATATTCAGCATTTTTTCTAATGAAAATGAATTTTGTTTACCAGTAAAAGTATGCATTTTAAAAGACTTTCAGATTTATGCTTTTTA
CGTGAAGCTGCTAAACTAAAAGTAAATGGAAGAAACCAAGTCTAGTAGGTTTTTTCTTTTTTTTTGTGGGGGTGGGATGGGGGAGGTTAG
TTACACTTAAAATATCTTCTCCAGAGACTGTATGCTCCTATACTAGACTGTAAGCTCTTTGAGGGCAGTCTGTCAGATTTATCTTTGTAT

>In-frame_ENST00000512285_ENST00000503362_TCGA-EJ-7123-01A_GALNT7_chr4_174169591_+_SPCS3_chr4_177243321_length(amino acids)=328AA_start in transcript=25_stop in transcript=1011
MRLKIGFILRSLLVVGSFLGLVVLWSSLTPRPDDPSPLSRMREDRDVNDPMPNRGGNGLAPGEDRFKPVVPWPHVEGVEVDLESIRRINK
AKNEQEHHAGGDSQKDIMQRQYLTFKPQTFTYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLGPEFKQAIQASIKEFGFNMVAS
DMISLDRSVNDLRQEEKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKD

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Fusion Gene PPI Analysis for GALNT7-SPCS3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for GALNT7-SPCS3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GALNT7-SPCS3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source