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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GANAB-SLC22A8 (FusionGDB2 ID:32236)

Fusion Gene Summary for GANAB-SLC22A8

check button Fusion gene summary
Fusion gene informationFusion gene name: GANAB-SLC22A8
Fusion gene ID: 32236
HgeneTgene
Gene symbol

GANAB

SLC22A8

Gene ID

23193

9376

Gene nameglucosidase II alpha subunitsolute carrier family 22 member 8
SynonymsG2AN|GIIA|GLUII|PKD3OAT3
Cytomap

11q12.3

11q12.3

Type of geneprotein-codingprotein-coding
Descriptionneutral alpha-glucosidase ABalpha-glucosidase 2solute carrier family 22 member 8hOAT3organic anion transporter 3solute carrier family 22 (organic anion transporter), member 8
Modification date2020031320200313
UniProtAcc

Q14697

.
Ensembl transtripts involved in fusion geneENST00000346178, ENST00000356638, 
ENST00000534779, ENST00000540933, 
ENST00000534422, 		ENST00000336232, 
ENST00000545207, ENST00000535878, 
ENST00000311438, ENST00000430500, 
ENST00000542795, 
Fusion gene scores* DoF score11 X 15 X 7=11554 X 5 X 3=60
# samples 194
** MAII scorelog2(19/1155*10)=-2.60382152797247
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GANAB [Title/Abstract] AND SLC22A8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGANAB(62396241)-SLC22A8(62768295), # samples:2
Anticipated loss of major functional domain due to fusion event.GANAB-SLC22A8 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
GANAB-SLC22A8 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GANAB-SLC22A8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GANAB-SLC22A8 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGANAB

GO:0006491

N-glycan processing

10929008


check buttonFusion gene breakpoints across GANAB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SLC22A8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EY-A54A-01AGANABchr11

62396241

-SLC22A8chr11

62768295

-
ChimerDB4UCECTCGA-EY-A54A-01AGANABchr11

62396241

-SLC22A8chr11

62768295

-


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Fusion Gene ORF analysis for GANAB-SLC22A8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000346178ENST00000336232GANABchr11

62396241

-SLC22A8chr11

62768295

-
Frame-shiftENST00000346178ENST00000545207GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000346178ENST00000535878GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000346178ENST00000311438GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000346178ENST00000430500GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000346178ENST00000542795GANABchr11

62396241

-SLC22A8chr11

62768295

-
Frame-shiftENST00000356638ENST00000336232GANABchr11

62396241

-SLC22A8chr11

62768295

-
Frame-shiftENST00000356638ENST00000545207GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000356638ENST00000535878GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000356638ENST00000311438GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000356638ENST00000430500GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000356638ENST00000542795GANABchr11

62396241

-SLC22A8chr11

62768295

-
Frame-shiftENST00000534779ENST00000336232GANABchr11

62396241

-SLC22A8chr11

62768295

-
Frame-shiftENST00000534779ENST00000545207GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000534779ENST00000535878GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000534779ENST00000311438GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000534779ENST00000430500GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000534779ENST00000542795GANABchr11

62396241

-SLC22A8chr11

62768295

-
In-frameENST00000540933ENST00000336232GANABchr11

62396241

-SLC22A8chr11

62768295

-
In-frameENST00000540933ENST00000545207GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000540933ENST00000535878GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000540933ENST00000311438GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000540933ENST00000430500GANABchr11

62396241

-SLC22A8chr11

62768295

-
5CDS-5UTRENST00000540933ENST00000542795GANABchr11

62396241

-SLC22A8chr11

62768295

-
intron-3CDSENST00000534422ENST00000336232GANABchr11

62396241

-SLC22A8chr11

62768295

-
intron-3CDSENST00000534422ENST00000545207GANABchr11

62396241

-SLC22A8chr11

62768295

-
intron-5UTRENST00000534422ENST00000535878GANABchr11

62396241

-SLC22A8chr11

62768295

-
intron-5UTRENST00000534422ENST00000311438GANABchr11

62396241

-SLC22A8chr11

62768295

-
intron-5UTRENST00000534422ENST00000430500GANABchr11

62396241

-SLC22A8chr11

62768295

-
intron-5UTRENST00000534422ENST00000542795GANABchr11

62396241

-SLC22A8chr11

62768295

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000540933GANABchr1162396241-ENST00000336232SLC22A8chr1162768295-379020811472111654
ENST00000540933GANABchr1162396241-ENST00000545207SLC22A8chr1162768295-353120811472111654

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000540933ENST00000336232GANABchr1162396241-SLC22A8chr1162768295-0.0037864920.9962135
ENST00000540933ENST00000545207GANABchr1162396241-SLC22A8chr1162768295-0.0041578210.99584216

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Fusion Genomic Features for GANAB-SLC22A8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GANAB-SLC22A8


check button Go to

FGviewer for the breakpoints of chr11:62396241-chr11:62768295

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GANAB

Q14697

.
FUNCTION: Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111145_154111.0543.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111176_176111.0543.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111198_212111.0543.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111234_236111.0543.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111258_327111.0543.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111349_354111.0543.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111376_386111.0543.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111408_411111.0543.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111433_471111.0543.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111493_542111.0543.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111145_154111.0543.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111176_176111.0543.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111198_212111.0543.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111234_236111.0543.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111258_327111.0543.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111349_354111.0543.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111376_386111.0543.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111408_411111.0543.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111433_471111.0543.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111493_542111.0543.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010145_1540420.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010176_1760420.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010198_2120420.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST000005358780101_90420.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010234_2360420.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010258_3270420.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST0000053587801031_1230420.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010349_3540420.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010376_3860420.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010408_4110420.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010433_4710420.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010493_5420420.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111145_15420.0452.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111176_17620.0452.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111198_21220.0452.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111234_23620.0452.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111258_32720.0452.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST0000054520711131_12320.0452.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111349_35420.0452.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111376_38620.0452.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111408_41120.0452.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111433_47120.0452.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111493_54220.0452.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111124_144111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111155_175111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111177_197111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111213_233111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111237_257111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111328_348111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111355_375111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111387_407111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111412_432111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000336232111472_492111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111124_144111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111155_175111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111177_197111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111213_233111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111237_257111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111328_348111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111355_375111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111387_407111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111412_432111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000430500111472_492111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST0000053587801010_300420.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010124_1440420.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010155_1750420.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010177_1970420.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010213_2330420.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010237_2570420.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010328_3480420.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010355_3750420.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010387_4070420.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010412_4320420.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000535878010472_4920420.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111124_14420.0452.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111155_17520.0452.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111177_19720.0452.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111213_23320.0452.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111237_25720.0452.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111328_34820.0452.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111355_37520.0452.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111387_40720.0452.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111412_43220.0452.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST00000545207111472_49220.0452.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC22A8chr11:62396241chr11:62768295ENST000003362321111_9111.0543.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST0000033623211131_123111.0543.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST000004305001111_9111.0543.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST0000043050011131_123111.0543.0Topological domainExtracellular
TgeneSLC22A8chr11:62396241chr11:62768295ENST000005452071111_920.0452.0Topological domainCytoplasmic
TgeneSLC22A8chr11:62396241chr11:62768295ENST0000033623211110_30111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST0000043050011110_30111.0543.0TransmembraneHelical
TgeneSLC22A8chr11:62396241chr11:62768295ENST0000054520711110_3020.0452.0TransmembraneHelical


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Fusion Gene Sequence for GANAB-SLC22A8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000540933_ENST00000336232_TCGA-EY-A54A-01A_GANAB_chr11_62396241_-_SLC22A8_chr11_62768295_length(transcript)=3790nt_BP=2081nt
TCTGCACAAGATGGCGGCGGTAGCGGCAGTGGCGGCGCGTAGGAGGCGGTCTTGGGCGTCTTTGGTACTGGCTTTTTTAGGGGTCTGCCT
GGGGATTACCCTTGCTGTGGATAGAAGCAACTTTAAGACCTGTGAAGAGAGTTCTTTCTGCAAGTGTTGCTGGTGCTAGAGCTTCAGGGG
CTTCAAAAGAACATGACTCGGTTCAGGATTGATGAGCTGGAGCCTCGGCGACCCCGATACCGTGTACCAGATGTTTTGGTGGCTGATCCA
CCAATAGCCCGGCTTTCTGTCTCTGGTCGTGATGAGAACAGTGTGGAGTTAACCATGGCTGAGGGACCCTACAAGATCATCTTGACAGCA
CGGCCATTCCGCCTTGACCTACTAGAGGACCGAAGTCTTTTGCTTAGTGTCAATGCCCGAGGACTCTTGGAGTTTGAGCATCAGAGGGCC
CCTAGGGTCTCGCAAGGATCAAAAGACCCAGCTGAGGGCGATGGGGCCCAGCCTGAGGAAACACCCAGGGATGGCGACAAGCCAGAGGAG
ACTCAGGGGAAGGCAGAGAAAGATGAGCCAGGAGCCTGGGAGGAGACATTCAAAACTCACTCTGACAGCAAGCCGTATGGCCCCATGTCT
GTGGGTTTGGACTTCTCTCTGCCAGGCATGGAGCATGTCTATGGGATCCCTGAGCATGCAGACAACCTGAGGCTGAAGGTCACTGAGGGT
GGGGAGCCATATCGCCTCTACAATTTGGATGTGTTCCAGTATGAGCTGTACAACCCAATGGCCTTGTATGGGTCTGTGCCTGTGCTCCTG
GCACACAACCCTCATCGCGACTTGGGCATCTTCTGGCTCAATGCTGCAGAGACCTGGGTTGATATATCTTCCAACACTGCCGGGAAGACC
CTGTTTGGGAAGATGATGGACTACCTGCAGGGCTCTGGGGAGACCCCACAGACAGATGTTCGCTGGATGTCAGAGACTGGCATCATTGAC
GTCTTCCTGCTGCTGGGGCCCTCCATCTCTGATGTTTTCCGGCAATATGCTAGTCTCACAGGAACCCAGGCGTTGCCCCCACTCTTCTCC
CTCGGCTACCACCAGAGCCGTTGGAACTACCGGGACGAGGCTGATGTGCTGGAAGTGGATCAGGGCTTTGATGATCACAACCTGCCCTGT
GATGTCATCTGGCTAGACATTGAACATGCTGATGGCAAGCGGTATTTCACCTGGGACCCCAGTCGCTTCCCTCAGCCCCGCACCATGCTT
GAGCGCTTGGCTTCTAAGAGGCGGAAGCTGGTGGCCATCGTAGACCCCCACATCAAGGTGGACTCCGGCTACCGAGTTCACGAGGAGCTG
CGGAACCTGGGGCTGTATGTTAAAACCCGGGATGGCTCTGACTATGAGGGCTGGTGCTGGCCAGGCTCAGCTGGTTACCCTGACTTCACT
AATCCCACGATGAGGGCCTGGTGGGCTAACATGTTCAGCTATGACAATTATGAGGGCTCAGCTCCCAACCTCTTTGTCTGGAATGACATG
AACGAACCATCTGTGTTCAATGGTCCTGAGGTCACCATGCTCAAGGATGCCCAGCATTATGGGGGCTGGGAGCACCGGGATGTGCATAAC
ATCTATGGCCTTTATGTGCACATGGCGACTGCTGATGGGCTGAGACAGCGCTCTGGGGGCATGGAACGCCCCTTTGTCCTGGCCAGGGCC
TTCTTCGCTGGCTCCCAGCGCTTTGGAGCCGTGTGGACAGGGGACAACACTGCCGAGTGGGACCATTTGAAGATCTCTATTCCTATGTGT
CTCAGCTTGGGGCTGGTGGGACTTTCCTTCTGTGGGGCGGATGTGGGTGGCTTCTTCAAAAACCCAGAGCCAGAGCTGCTTGTGCGCTGG
TACCAGATGGGTGCTTACCAGCCATTCTTCCGGGCACATGCCCACTTGGACACTGGGCGACGAGAGCCATGGCTGTTACCATCTCAGCAC
AATGATATAATCCGAGATGCCTTGGGCCAGCGATATTCTTTGCTGCCCTTCTGGTACACCCTCTTATATCAGGCCCATCGGGAAGGCATT
CCTGTCATGAGTGGGACTTGGTGTGCAACTCCAACAAACTGAAGGAGATGGCCCAGTCTATCTTCATGGCAGGTATACTGATTGGAGGGC
TCGTGCTTGGAGACCTGTCTGACAGGTTTGGCCGCAGGCCCATCCTGACCTGCAGCTACCTGCTGCTGGCAGCCAGCGGCTCCGGTGCAG
CCTTCAGCCCCACCTTCCCCATCTACATGGTCTTCCGCTTCCTGTGTGGCTTTGGCATCTCAGGCATTACCCTGAGCACCGTCATCTTGA
ATGTGGAATGGGTGCCTACCCGGATGCGGGCCATCATGTCGACAGCACTCGGGTACTGCTACACCTTTGGCCAGTTCATTCTGCCCGGCC
TGGCCTACGCCATCCCCCAGTGGCGTTGGCTGCAGTTAACTGTGTCCATTCCCTTCTTCGTCTTCTTCCTATCATCCTGGTGGACACCAG
AGTCCATACGCTGGTTGGTCTTGTCTGGAAAGTCCTCGAAGGCCCTGAAGATACTCCGGCGGGTGGCTGTCTTCAATGGCAAGAAGGAAG
AGGGAGAAAGGCTCAGCTTGGAGGAGCTCAAACTCAACCTGCAGAAGGAGATCTCCTTGGCCAAGGCCAAGTACACCGCAAGTGACCTGT
TCCGGATACCCATGCTGCGCCGCATGACCTTCTGTCTTTCCCTGGCCTGGTTTGCTACCGGTTTTGCCTACTATAGTTTGGCTATGGGTG
TGGAAGAATTTGGAGTCAACCTCTACATCCTCCAGATCATCTTTGGTGGGGTCGATGTCCCAGCCAAGTTCATCACCATCCTCTCCTTAA
GCTACCTGGGCCGGCATACCACTCAGGCCGCTGCCCTGCTCCTGGCAGGAGGGGCCATCTTGGCTCTCACCTTTGTGCCCTTGGACTTGC
AGACCGTGAGGACAGTATTGGCTGTGTTTGGGAAGGGATGCCTATCCAGCTCCTTCAGCTGCCTCTTCCTCTACACAAGTGAATTATACC
CCACAGTCATCAGGCAAACAGGTATGGGCGTAAGTAACCTGTGGACCCGCGTGGGAAGCATGGTGTCCCCGCTGGTGAAAATCACGGGTG
AGGTACAGCCCTTCATCCCCAATATCATCTACGGGATCACCGCCCTCCTCGGGGGCAGTGCTGCCCTCTTCCTGCCTGAGACCCTGAATC
AGCCCTTGCCAGAGACTATCGAAGACCTGGAAAACTGGTCCCTGCGGGCAAAGAAGCCAAAGCAGGAGCCAGAGGTGGAAAAGGCCTCCC
AGAGGATCCCTCTACAGCCTCACGGACCAGGCCTGGGCTCCAGCTGAGGACAACGGAACCCCCTTTCCCTGCCCTCCAGAGACTGATCCT
AGCCAGGCACCTTAGGAGTATAGGGAGGCCCCATATAGGTCCATCCTCCTAGGATGAAGCCTTCTGAGAGCTTGGTGAAGGTGTCTCCAT
CACCACCACCAGAGCCTCCTGCCCAGCCCTGGCCAGTTCAAAGGTTCAGCCATCCCTGCCCTTGTTCTCCCTGCAACCCAGGCCCTGCCA
TTCTTCTGTCTAGCCCTTCCCCACTGGCCACCTTCCCCCACTGTCCCGGTCCTCTTCCCCTGAGGTCCCCTGATATCCCCTGGCTCAGTC
CTAACAAGACTGAGTCTTAACAAGATGAGAAGTCCTCCCCTTCTTGCCTCCCACACTTTTCTTTGATGGGAGGTTTCAATAAACAGCGAT

>In-frame_ENST00000540933_ENST00000336232_TCGA-EY-A54A-01A_GANAB_chr11_62396241_-_SLC22A8_chr11_62768295_length(amino acids)=654AA_start in transcript=147_stop in transcript=2111
MQVLLVLELQGLQKNMTRFRIDELEPRRPRYRVPDVLVADPPIARLSVSGRDENSVELTMAEGPYKIILTARPFRLDLLEDRSLLLSVNA
RGLLEFEHQRAPRVSQGSKDPAEGDGAQPEETPRDGDKPEETQGKAEKDEPGAWEETFKTHSDSKPYGPMSVGLDFSLPGMEHVYGIPEH
ADNLRLKVTEGGEPYRLYNLDVFQYELYNPMALYGSVPVLLAHNPHRDLGIFWLNAAETWVDISSNTAGKTLFGKMMDYLQGSGETPQTD
VRWMSETGIIDVFLLLGPSISDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNLPCDVIWLDIEHADGKRYFTWD
PSRFPQPRTMLERLASKRRKLVAIVDPHIKVDSGYRVHEELRNLGLYVKTRDGSDYEGWCWPGSAGYPDFTNPTMRAWWANMFSYDNYEG
SAPNLFVWNDMNEPSVFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADGLRQRSGGMERPFVLARAFFAGSQRFGAVWTGDNTAE
WDHLKISIPMCLSLGLVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQHNDIIRDALGQRYSLLPFWY

--------------------------------------------------------------
>In-frame_ENST00000540933_ENST00000545207_TCGA-EY-A54A-01A_GANAB_chr11_62396241_-_SLC22A8_chr11_62768295_length(transcript)=3531nt_BP=2081nt
TCTGCACAAGATGGCGGCGGTAGCGGCAGTGGCGGCGCGTAGGAGGCGGTCTTGGGCGTCTTTGGTACTGGCTTTTTTAGGGGTCTGCCT
GGGGATTACCCTTGCTGTGGATAGAAGCAACTTTAAGACCTGTGAAGAGAGTTCTTTCTGCAAGTGTTGCTGGTGCTAGAGCTTCAGGGG
CTTCAAAAGAACATGACTCGGTTCAGGATTGATGAGCTGGAGCCTCGGCGACCCCGATACCGTGTACCAGATGTTTTGGTGGCTGATCCA
CCAATAGCCCGGCTTTCTGTCTCTGGTCGTGATGAGAACAGTGTGGAGTTAACCATGGCTGAGGGACCCTACAAGATCATCTTGACAGCA
CGGCCATTCCGCCTTGACCTACTAGAGGACCGAAGTCTTTTGCTTAGTGTCAATGCCCGAGGACTCTTGGAGTTTGAGCATCAGAGGGCC
CCTAGGGTCTCGCAAGGATCAAAAGACCCAGCTGAGGGCGATGGGGCCCAGCCTGAGGAAACACCCAGGGATGGCGACAAGCCAGAGGAG
ACTCAGGGGAAGGCAGAGAAAGATGAGCCAGGAGCCTGGGAGGAGACATTCAAAACTCACTCTGACAGCAAGCCGTATGGCCCCATGTCT
GTGGGTTTGGACTTCTCTCTGCCAGGCATGGAGCATGTCTATGGGATCCCTGAGCATGCAGACAACCTGAGGCTGAAGGTCACTGAGGGT
GGGGAGCCATATCGCCTCTACAATTTGGATGTGTTCCAGTATGAGCTGTACAACCCAATGGCCTTGTATGGGTCTGTGCCTGTGCTCCTG
GCACACAACCCTCATCGCGACTTGGGCATCTTCTGGCTCAATGCTGCAGAGACCTGGGTTGATATATCTTCCAACACTGCCGGGAAGACC
CTGTTTGGGAAGATGATGGACTACCTGCAGGGCTCTGGGGAGACCCCACAGACAGATGTTCGCTGGATGTCAGAGACTGGCATCATTGAC
GTCTTCCTGCTGCTGGGGCCCTCCATCTCTGATGTTTTCCGGCAATATGCTAGTCTCACAGGAACCCAGGCGTTGCCCCCACTCTTCTCC
CTCGGCTACCACCAGAGCCGTTGGAACTACCGGGACGAGGCTGATGTGCTGGAAGTGGATCAGGGCTTTGATGATCACAACCTGCCCTGT
GATGTCATCTGGCTAGACATTGAACATGCTGATGGCAAGCGGTATTTCACCTGGGACCCCAGTCGCTTCCCTCAGCCCCGCACCATGCTT
GAGCGCTTGGCTTCTAAGAGGCGGAAGCTGGTGGCCATCGTAGACCCCCACATCAAGGTGGACTCCGGCTACCGAGTTCACGAGGAGCTG
CGGAACCTGGGGCTGTATGTTAAAACCCGGGATGGCTCTGACTATGAGGGCTGGTGCTGGCCAGGCTCAGCTGGTTACCCTGACTTCACT
AATCCCACGATGAGGGCCTGGTGGGCTAACATGTTCAGCTATGACAATTATGAGGGCTCAGCTCCCAACCTCTTTGTCTGGAATGACATG
AACGAACCATCTGTGTTCAATGGTCCTGAGGTCACCATGCTCAAGGATGCCCAGCATTATGGGGGCTGGGAGCACCGGGATGTGCATAAC
ATCTATGGCCTTTATGTGCACATGGCGACTGCTGATGGGCTGAGACAGCGCTCTGGGGGCATGGAACGCCCCTTTGTCCTGGCCAGGGCC
TTCTTCGCTGGCTCCCAGCGCTTTGGAGCCGTGTGGACAGGGGACAACACTGCCGAGTGGGACCATTTGAAGATCTCTATTCCTATGTGT
CTCAGCTTGGGGCTGGTGGGACTTTCCTTCTGTGGGGCGGATGTGGGTGGCTTCTTCAAAAACCCAGAGCCAGAGCTGCTTGTGCGCTGG
TACCAGATGGGTGCTTACCAGCCATTCTTCCGGGCACATGCCCACTTGGACACTGGGCGACGAGAGCCATGGCTGTTACCATCTCAGCAC
AATGATATAATCCGAGATGCCTTGGGCCAGCGATATTCTTTGCTGCCCTTCTGGTACACCCTCTTATATCAGGCCCATCGGGAAGGCATT
CCTGTCATGAGTGGGACTTGGTGTGCAACTCCAACAAACTGAAGGAGATGGCCCAGTCTATCTTCATGGCAGGTATACTGATTGGAGGGC
TCGTGCTTGGAGACCTGTCTGACAGGTTTGGCCGCAGGCCCATCCTGACCTGCAGCTACCTGCTGCTGGCAGCCAGCGGCTCCGGTGCAG
CCTTCAGCCCCACCTTCCCCATCTACATGGTCTTCCGCTTCCTGTGTGGCTTTGGCATCTCAGGCATTACCCTGAGCACCGTCATCTTGA
ATGTGGAATGGGTGCCTACCCGGATGCGGGCCATCATGTCGACAGCACTCGGGTACTGCTACACCTTTGGCCAGTTCATTCTGCCCGGCC
TGGCCTACGCCATCCCCCAGTGGCGTTGGCTGCAGTTAACTGTGTCCATTCCCTTCTTCGTCTTCTTCCTATCATCCTGGTGGACACCAG
AGTCCATACGCTGGTTGGTCTTGTCTGGAAAGTCCTCGAAGGCCCTGAAGATACTCCGGCGGGTGGCTGTCTTCAATGGCAAGAAGGAAG
AGGGAGAAAGGCTCAGCTTGGAGGAGCTCAAACTCAACCTGCAGAAGGAGATCTCCTTGGCCAAGGCCAAGTACACCGCAAGTGACCTGT
TCCGGATACCCATGCTGCGCCGCATGACCTTCTGTCTTTCCCTGGCCTGGTTTGCTACCGGTTTTGCCTACTATAGTTTGGCTATGGGTG
TGGAAGAATTTGGAGTCAACCTCTACATCCTCCAGATCATCTTTGGTGGGGTCGATGTCCCAGCCAAGTTCATCACCATCCTCTCCTTAA
GCTACCTGGGCCGGCATACCACTCAGGCCGCTGCCCTGCTCCTGGCAGGAGGGGCCATCTTGGCTCTCACCTTTGTGCCCTTGGACTTGC
AGACCGTGAGGACAGTATTGGCTGTGTTTGGGAAGGGATGCCTATCCAGCTCCTTCAGCTGCCTCTTCCTCTACACAAGTGAATTATACC
CCACAGTCATCAGGCAAACAGGTATGGGCGTAAGTAACCTGTGGACCCGCGTGGGAAGCATGGTGTCCCCGCTGGTGAAAATCACGGGTG
AGGTACAGCCCTTCATCCCCAATATCATCTACGGGATCACCGCCCTCCTCGGGGGCAGTGCTGCCCTCTTCCTGCCTGAGACCCTGAATC
AGCCCTTGCCAGAGACTATCGAAGACCTGGAAAACTGGTCCCTGCGGGCAAAGAAGCCAAAGCAGGAGCCAGAGGTGGAAAAGGCCTCCC
AGAGGATCCCTCTACAGCCTCACGGACCAGGCCTGGGCTCCAGCTGAGGACAACGGAACCCCCTTTCCCTGCCCTCCAGAGACTGATCCT
AGCCAGGCACCTTAGGAGTATAGGGAGGCCCCATATAGGTCCATCCTCCTAGGATGAAGCCTTCTGAGAGCTTGGTGAAGGTGTCTCCAT

>In-frame_ENST00000540933_ENST00000545207_TCGA-EY-A54A-01A_GANAB_chr11_62396241_-_SLC22A8_chr11_62768295_length(amino acids)=654AA_start in transcript=147_stop in transcript=2111
MQVLLVLELQGLQKNMTRFRIDELEPRRPRYRVPDVLVADPPIARLSVSGRDENSVELTMAEGPYKIILTARPFRLDLLEDRSLLLSVNA
RGLLEFEHQRAPRVSQGSKDPAEGDGAQPEETPRDGDKPEETQGKAEKDEPGAWEETFKTHSDSKPYGPMSVGLDFSLPGMEHVYGIPEH
ADNLRLKVTEGGEPYRLYNLDVFQYELYNPMALYGSVPVLLAHNPHRDLGIFWLNAAETWVDISSNTAGKTLFGKMMDYLQGSGETPQTD
VRWMSETGIIDVFLLLGPSISDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNLPCDVIWLDIEHADGKRYFTWD
PSRFPQPRTMLERLASKRRKLVAIVDPHIKVDSGYRVHEELRNLGLYVKTRDGSDYEGWCWPGSAGYPDFTNPTMRAWWANMFSYDNYEG
SAPNLFVWNDMNEPSVFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADGLRQRSGGMERPFVLARAFFAGSQRFGAVWTGDNTAE
WDHLKISIPMCLSLGLVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQHNDIIRDALGQRYSLLPFWY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GANAB-SLC22A8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GANAB-SLC22A8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGANABQ14697DB00491MiglitolAntagonistSmall moleculeApproved
HgeneGANABQ14697DB00491MiglitolAntagonistSmall moleculeApproved
HgeneGANABQ14697DB00491MiglitolAntagonistSmall moleculeApproved

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Related Diseases for GANAB-SLC22A8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGANABC3887964POLYCYSTIC KIDNEY DISEASE 3 WITH OR WITHOUT POLYCYSTIC LIVER DISEASE2GENOMICS_ENGLAND;UNIPROT
HgeneGANABC0019193Hepatitis, Toxic1CTD_human
HgeneGANABC0085413Polycystic Kidney, Autosomal Dominant1CTD_human;ORPHANET
HgeneGANABC0860207Drug-Induced Liver Disease1CTD_human
HgeneGANABC1262760Hepatitis, Drug-Induced1CTD_human
HgeneGANABC3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneGANABC4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneGANABC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneSLC22A8C0015695Fatty Liver1CTD_human
TgeneSLC22A8C0019193Hepatitis, Toxic1CTD_human
TgeneSLC22A8C0021400Influenza1CTD_human
TgeneSLC22A8C0023890Liver Cirrhosis1CTD_human
TgeneSLC22A8C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneSLC22A8C0239946Fibrosis, Liver1CTD_human
TgeneSLC22A8C0860207Drug-Induced Liver Disease1CTD_human
TgeneSLC22A8C1262760Hepatitis, Drug-Induced1CTD_human
TgeneSLC22A8C2711227Steatohepatitis1CTD_human
TgeneSLC22A8C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneSLC22A8C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneSLC22A8C4279912Chemically-Induced Liver Toxicity1CTD_human