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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:GARNL3-ITM2B (FusionGDB2 ID:32337) |
Fusion Gene Summary for GARNL3-ITM2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GARNL3-ITM2B | Fusion gene ID: 32337 | Hgene | Tgene | Gene symbol | GARNL3 | ITM2B | Gene ID | 84253 | 9445 |
| Gene name | GTPase activating Rap/RanGAP domain like 3 | integral membrane protein 2B | |
| Synonyms | bA356B19.1 | ABRI|BRI|BRI2|BRICD2B|E25B|E3-16|FBD|RDGCA|imBRI2 | |
| Cytomap | 9q33.3 | 13q14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | GTPase-activating Rap/Ran-GAP domain-like protein 3GTPase activating RANGAP domain-like 3 | integral membrane protein 2BABri/ADan amyloid peptideBRICHOS domain containing 2Bepididymis secretory sperm binding proteinimmature BRI2transmembrane protein BRI | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q9Y287 | |
| Ensembl transtripts involved in fusion gene | ENST00000435213, ENST00000314904, ENST00000373387, ENST00000496711, | ENST00000378565, ENST00000378549, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 19 X 11 X 7=1463 |
| # samples | 4 | 22 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(22/1463*10)=-2.73335434061383 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GARNL3 [Title/Abstract] AND ITM2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | GARNL3(130107756)-ITM2B(48827944), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ITM2B | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process | 16027166|18524908 |
| Fusion gene breakpoints across GARNL3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across ITM2B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-IN-7808-01A | GARNL3 | chr9 | 130107756 | + | ITM2B | chr13 | 48827944 | + |
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Fusion Gene ORF analysis for GARNL3-ITM2B |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000435213 | ENST00000378565 | GARNL3 | chr9 | 130107756 | + | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000435213 | ENST00000378549 | GARNL3 | chr9 | 130107756 | + | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000314904 | ENST00000378565 | GARNL3 | chr9 | 130107756 | + | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000314904 | ENST00000378549 | GARNL3 | chr9 | 130107756 | + | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000373387 | ENST00000378565 | GARNL3 | chr9 | 130107756 | + | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000373387 | ENST00000378549 | GARNL3 | chr9 | 130107756 | + | ITM2B | chr13 | 48827944 | + |
| intron-3CDS | ENST00000496711 | ENST00000378565 | GARNL3 | chr9 | 130107756 | + | ITM2B | chr13 | 48827944 | + |
| intron-3CDS | ENST00000496711 | ENST00000378549 | GARNL3 | chr9 | 130107756 | + | ITM2B | chr13 | 48827944 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000435213 | GARNL3 | chr9 | 130107756 | + | ENST00000378565 | ITM2B | chr13 | 48827944 | + | 3479 | 1695 | 330 | 2378 | 682 |
| ENST00000435213 | GARNL3 | chr9 | 130107756 | + | ENST00000378549 | ITM2B | chr13 | 48827944 | + | 2225 | 1695 | 330 | 2060 | 576 |
| ENST00000314904 | GARNL3 | chr9 | 130107756 | + | ENST00000378565 | ITM2B | chr13 | 48827944 | + | 3616 | 1832 | 395 | 2515 | 706 |
| ENST00000314904 | GARNL3 | chr9 | 130107756 | + | ENST00000378549 | ITM2B | chr13 | 48827944 | + | 2362 | 1832 | 395 | 2197 | 600 |
| ENST00000373387 | GARNL3 | chr9 | 130107756 | + | ENST00000378565 | ITM2B | chr13 | 48827944 | + | 3567 | 1783 | 346 | 2466 | 706 |
| ENST00000373387 | GARNL3 | chr9 | 130107756 | + | ENST00000378549 | ITM2B | chr13 | 48827944 | + | 2313 | 1783 | 346 | 2148 | 600 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000435213 | ENST00000378565 | GARNL3 | chr9 | 130107756 | + | ITM2B | chr13 | 48827944 | + | 6.55E-05 | 0.99993455 |
| ENST00000435213 | ENST00000378549 | GARNL3 | chr9 | 130107756 | + | ITM2B | chr13 | 48827944 | + | 0.000227981 | 0.999772 |
| ENST00000314904 | ENST00000378565 | GARNL3 | chr9 | 130107756 | + | ITM2B | chr13 | 48827944 | + | 0.000138463 | 0.9998615 |
| ENST00000314904 | ENST00000378549 | GARNL3 | chr9 | 130107756 | + | ITM2B | chr13 | 48827944 | + | 0.000313684 | 0.99968636 |
| ENST00000373387 | ENST00000378565 | GARNL3 | chr9 | 130107756 | + | ITM2B | chr13 | 48827944 | + | 0.000141973 | 0.999858 |
| ENST00000373387 | ENST00000378549 | GARNL3 | chr9 | 130107756 | + | ITM2B | chr13 | 48827944 | + | 0.000340908 | 0.99965906 |
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Fusion Genomic Features for GARNL3-ITM2B |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| GARNL3 | chr9 | 130107756 | + | ITM2B | chr13 | 48827943 | + | 0.63915455 | 0.36084542 |
| GARNL3 | chr9 | 130107756 | + | ITM2B | chr13 | 48827943 | + | 0.63915455 | 0.36084542 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for GARNL3-ITM2B |
| Go to FGviewer for the breakpoints of chr9:130107756-chr13:48827944 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | ITM2B |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.; FUNCTION: Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.; FUNCTION: Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GARNL3 | chr9:130107756 | chr13:48827944 | ENST00000314904 | + | 16 | 27 | 191_407 | 477.0 | 811.6666666666666 | Domain | Rap-GAP |
| Hgene | GARNL3 | chr9:130107756 | chr13:48827944 | ENST00000373387 | + | 16 | 28 | 191_407 | 477.0 | 1014.0 | Domain | Rap-GAP |
| Tgene | ITM2B | chr9:130107756 | chr13:48827944 | ENST00000378565 | 0 | 6 | 137_231 | 39.0 | 267.0 | Domain | BRICHOS | |
| Tgene | ITM2B | chr9:130107756 | chr13:48827944 | ENST00000378565 | 0 | 6 | 76_266 | 39.0 | 267.0 | Topological domain | Lumenal | |
| Tgene | ITM2B | chr9:130107756 | chr13:48827944 | ENST00000378565 | 0 | 6 | 55_75 | 39.0 | 267.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GARNL3 | chr9:130107756 | chr13:48827944 | ENST00000314904 | + | 16 | 27 | 489_800 | 477.0 | 811.6666666666666 | Domain | CNH |
| Hgene | GARNL3 | chr9:130107756 | chr13:48827944 | ENST00000373387 | + | 16 | 28 | 489_800 | 477.0 | 1014.0 | Domain | CNH |
| Tgene | ITM2B | chr9:130107756 | chr13:48827944 | ENST00000378565 | 0 | 6 | 1_54 | 39.0 | 267.0 | Topological domain | Cytoplasmic |
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Fusion Gene Sequence for GARNL3-ITM2B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000435213_ENST00000378565_TCGA-IN-7808-01A_GARNL3_chr9_130107756_+_ITM2B_chr13_48827944_length(transcript)=3479nt_BP=1695nt ACTAGAAGCAAGAATGTAGCCTGGGTAATATCTGGAACACTTTCAAACTGCATGCATTGATGTGTTGCCCATTTTCAGCTAAGAGAGGGA GGACTACAAAAGGTTAAATTTCTCATATAAGATTAATTCAGCCATCTCTGTGAAATGGTGGAAGCAGAATGCCATTAGACTCTCTAATCT CATTTCTCTCATGCTGTCTTTCTTGGAGCCTGTCAAACAGTGTCCTGGCAGAGAGTCAGTTCTCTGGTTGCTAAACATCAGAGTCAGTCT CTTTCTGCATGTGCCAAGAGGGCTGTAATTTAGAAAATGCAACCTACCTTTTAAGGAAGGATGAAAAGCTCTGTCTCGGAAGACCTAGGC TGTAGACGTGGGGATTTCAGTAGGAAACATTATGGATCTGTGGAGCTGCTTATTTCCAGTGATGCTGATGGAGCCATCCAAAGGGCTGGA AGATTCAGAGTGGAAAATGGCTCTTCAGATGAGAATGCAACTGCCCTGCCTGGTACTTGGCGAAGAACAGACGTGCACTTAGAGAACCCA GAATACCACACCAGATGGTATTTCAAATATTTTTTAGGACAAGTCCATCAGAACTACATTGGAAACGATGCCGAGAAGAGCCCTTTCTTC TTGTCCGTGACCCTTTCTGACCAAAACAATCAACGTGTCCCTCAATACCGTGCAATTCTTTGGAGAAAAACAGGTACCCAGAAAATATGC CTTCCCTACAGTCCCACAAAAACTCTTTCTGTGAAGTCCATCTTAAGTGCCATGAATCTGGACAAATTTGAGAAAGGCCCCAGGGAAATT TTTCATCCTGAAATACAAAAGGACTTGCTGGTTCTTGAAGAACAAGAGGGCTCTGTGAATTTCAAGTTTGGGGTTCTTTTTGCCAAAGAT GGGCAGCTCACTGATGATGAGATGTTCAGCAATGAAATTGGAAGCGAGCCTTTTCAAAAATTTTTAAATCTTCTGGGTGACACAATCACT CTAAAGGGCTGGACGGGCTACCGTGGCGGTCTGGATACCAAAAATGATACCACAGGGATACATTCAGTTTATACTGTGTACCAAGGGCAT GAGATCATGTTTCATGTTTCCACCATGTTGCCATATTCCAAAGAGAACAAACAGCAGGTGGAAAGGAAACGCCACATTGGAAACGATATC GTCACCATTGTGTTCCAAGAAGGAGAGGAATCTTCTCCTGCCTTTAAGCCTTCCATGATCCGCTCCCACTTTACACATATTTTTGCCTTA GTGAGATACAATCAACAAAATGACAATTACAGGCTGAAAATATTTTCAGAAGAGAGCGTACCACTCTTTGGCCCTCCCTTGCCAACTCCA CCAGTGTTTACAGACCACCAGGAATTCAGGGACTTTTTGCTAGTGAAATTAATTAATGGTGAAAAAGCCACTTTGGAAACCCCAACATTT GCCCAGAAACGTCGGCGTACCCTGGATATGTTGATTAGATCTTTACACCAGGATTTGATGCCAGATTTGCATAAGAACATGCTTAATAGA CGATCTTTTAGTGATGTCTTACCAGAGTCACCCAAGTCAGCGCGGAAGAAAGAGGAGGCCCGCCAGGCGGAGTTTGTTAGAATAGGGCAG GCACTAAAACTGAAATCCATTGTGAGAGGGGATGCTCCATCAAGCTTGGCAGCTTCAGGGATCTGTAAAAAAGAGGACCCAGATGATGTG GTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATAC TTGTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCT GCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTC CCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGC TATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCT CAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCAT GACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTT GAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCA CCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATT CAATTAAAACCATTACCTTAAAATTTTTTTCTTTCGAAGTGTGGTGTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATAGATAATA GTACATGTCACCTTAGGTAGTAGGAAGAATTACAATTTCTTTAAATCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGAC GGATTATCTAGAGAATAATCATATATATGCATACGTAAAAATGGACCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTT TGTTAGTGCATTTGAGCACACATTTTAATTTTCCTCTAATTAAAATGTGCAGTATTTTCAGTGTCAAATATATTTAACTATTTAGAGAAT GATTTCCACCTTTATGTTTTAATATCCTAGGCATCTGCTGTAATAATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACT AATTTGTATAACCCATATCTGTGCAATGGAATATAAATATCACAAAGTTGTTTAACTAGACTGCGTGTTGTTTTTCCCGTATAATAAAAC CAAAGAATAGTTTGGTTCTTCAAATCTTAAGAGAATCCACATAAAAGAAGAAACTATTTTTTAAAAATTCACTTCTATATATACAATGAG TAAAATCACAGATTTTTTCTTTAAATAAAAATAAGTCATTTTAATAACTAAACCAGATTCTTTGTGGATACTATTAAAGTAACATTTAAG CCTCAACCTTGAATGATGTTGTTTAATATAAAATGCTTTTATTTTTGATGGAAAGGCAATCAAAGCCTAAAGTTTCCAAGGAACGTAAAA TAACTGTGCTTCTCTGAGAATGCCCGCCTCACAAGTGGAACATTTTGAGTTAATAATGATGATTTTTATGTTTCTAAGGTTGCTTCCTCT >In-frame_ENST00000435213_ENST00000378565_TCGA-IN-7808-01A_GARNL3_chr9_130107756_+_ITM2B_chr13_48827944_length(amino acids)=682AA_start in transcript=330_stop in transcript=2378 MKSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSSDENATALPGTWRRTDVHLENPEYHTRWYFKYFLGQVHQNYI GNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQEGSVN FKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQV ERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQNDNYRLKIFSEESVPLFGPPLPTPPVFTDHQEFRDFLLVKLING EKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFVRIGQALKLKSIVRGDAPSSLAASG ICKKEDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEE EEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDH -------------------------------------------------------------- >In-frame_ENST00000435213_ENST00000378549_TCGA-IN-7808-01A_GARNL3_chr9_130107756_+_ITM2B_chr13_48827944_length(transcript)=2225nt_BP=1695nt ACTAGAAGCAAGAATGTAGCCTGGGTAATATCTGGAACACTTTCAAACTGCATGCATTGATGTGTTGCCCATTTTCAGCTAAGAGAGGGA GGACTACAAAAGGTTAAATTTCTCATATAAGATTAATTCAGCCATCTCTGTGAAATGGTGGAAGCAGAATGCCATTAGACTCTCTAATCT CATTTCTCTCATGCTGTCTTTCTTGGAGCCTGTCAAACAGTGTCCTGGCAGAGAGTCAGTTCTCTGGTTGCTAAACATCAGAGTCAGTCT CTTTCTGCATGTGCCAAGAGGGCTGTAATTTAGAAAATGCAACCTACCTTTTAAGGAAGGATGAAAAGCTCTGTCTCGGAAGACCTAGGC TGTAGACGTGGGGATTTCAGTAGGAAACATTATGGATCTGTGGAGCTGCTTATTTCCAGTGATGCTGATGGAGCCATCCAAAGGGCTGGA AGATTCAGAGTGGAAAATGGCTCTTCAGATGAGAATGCAACTGCCCTGCCTGGTACTTGGCGAAGAACAGACGTGCACTTAGAGAACCCA GAATACCACACCAGATGGTATTTCAAATATTTTTTAGGACAAGTCCATCAGAACTACATTGGAAACGATGCCGAGAAGAGCCCTTTCTTC TTGTCCGTGACCCTTTCTGACCAAAACAATCAACGTGTCCCTCAATACCGTGCAATTCTTTGGAGAAAAACAGGTACCCAGAAAATATGC CTTCCCTACAGTCCCACAAAAACTCTTTCTGTGAAGTCCATCTTAAGTGCCATGAATCTGGACAAATTTGAGAAAGGCCCCAGGGAAATT TTTCATCCTGAAATACAAAAGGACTTGCTGGTTCTTGAAGAACAAGAGGGCTCTGTGAATTTCAAGTTTGGGGTTCTTTTTGCCAAAGAT GGGCAGCTCACTGATGATGAGATGTTCAGCAATGAAATTGGAAGCGAGCCTTTTCAAAAATTTTTAAATCTTCTGGGTGACACAATCACT CTAAAGGGCTGGACGGGCTACCGTGGCGGTCTGGATACCAAAAATGATACCACAGGGATACATTCAGTTTATACTGTGTACCAAGGGCAT GAGATCATGTTTCATGTTTCCACCATGTTGCCATATTCCAAAGAGAACAAACAGCAGGTGGAAAGGAAACGCCACATTGGAAACGATATC GTCACCATTGTGTTCCAAGAAGGAGAGGAATCTTCTCCTGCCTTTAAGCCTTCCATGATCCGCTCCCACTTTACACATATTTTTGCCTTA GTGAGATACAATCAACAAAATGACAATTACAGGCTGAAAATATTTTCAGAAGAGAGCGTACCACTCTTTGGCCCTCCCTTGCCAACTCCA CCAGTGTTTACAGACCACCAGGAATTCAGGGACTTTTTGCTAGTGAAATTAATTAATGGTGAAAAAGCCACTTTGGAAACCCCAACATTT GCCCAGAAACGTCGGCGTACCCTGGATATGTTGATTAGATCTTTACACCAGGATTTGATGCCAGATTTGCATAAGAACATGCTTAATAGA CGATCTTTTAGTGATGTCTTACCAGAGTCACCCAAGTCAGCGCGGAAGAAAGAGGAGGCCCGCCAGGCGGAGTTTGTTAGAATAGGGCAG GCACTAAAACTGAAATCCATTGTGAGAGGGGATGCTCCATCAAGCTTGGCAGCTTCAGGGATCTGTAAAAAAGAGGACCCAGATGATGTG GTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATAC TTGTACAAATATTTTGCACTTCAAGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAA AACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATT CAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAG AAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGT >In-frame_ENST00000435213_ENST00000378549_TCGA-IN-7808-01A_GARNL3_chr9_130107756_+_ITM2B_chr13_48827944_length(amino acids)=576AA_start in transcript=330_stop in transcript=2060 MKSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSSDENATALPGTWRRTDVHLENPEYHTRWYFKYFLGQVHQNYI GNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQEGSVN FKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQV ERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQNDNYRLKIFSEESVPLFGPPLPTPPVFTDHQEFRDFLLVKLING EKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFVRIGQALKLKSIVRGDAPSSLAASG ICKKEDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYK -------------------------------------------------------------- >In-frame_ENST00000314904_ENST00000378565_TCGA-IN-7808-01A_GARNL3_chr9_130107756_+_ITM2B_chr13_48827944_length(transcript)=3616nt_BP=1832nt CTCTTACTTAAAATATAGCATTAAATAATGCTGGTTATTTTTATGTTGCATATTTGGGACAAAGAGCTCTCTTAAATGAAAGATAATTGC AAGATCCGGTTCAGCAGCTTTGTCCCTTGCCTCAAGTTTACTGCAGGGCTTCTCTCCTCTCTGGTTATACAGAAATGAAATTATAAACCA CCAGTAACCTTGGAAATTTCAATCGATTCCAAATGACTAAATATTTAATTGAATCATTGCCTATACTTCCAGGGATGACTCTGGCGTTTG CTTTTTATTGAGGGCTCCATGAAAGCCAGGCTCTGCAATGGCTGCTGGGGACTGTGTCTGTTGCAAGGAGGCTCCCCTGCAGTGAGGAGC CGGGGCACTGCAAGTCTGTTCCATAGCAGCCCTTTTTGCAAATGGTAGTTGATTTTTGCAGAAGGTTTGTGGCCAGATCGCTATGTATAA TACTGATGAAGCATTTTTGTTCCAGCTCTGTCTCGGAAGACCTAGGCTGTAGACGTGGGGATTTCAGTAGGAAACATTATGGATCTGTGG AGCTGCTTATTTCCAGTGATGCTGATGGAGCCATCCAAAGGGCTGGAAGATTCAGAGTGGAAAATGGCTCTTCAGATGAGAATGCAACTG CCCTGCCTGGTACTTGGCGAAGAACAGACGTGCACTTAGAGAACCCAGAATACCACACCAGATGGTATTTCAAATATTTTTTAGGACAAG TCCATCAGAACTACATTGGAAACGATGCCGAGAAGAGCCCTTTCTTCTTGTCCGTGACCCTTTCTGACCAAAACAATCAACGTGTCCCTC AATACCGTGCAATTCTTTGGAGAAAAACAGGTACCCAGAAAATATGCCTTCCCTACAGTCCCACAAAAACTCTTTCTGTGAAGTCCATCT TAAGTGCCATGAATCTGGACAAATTTGAGAAAGGCCCCAGGGAAATTTTTCATCCTGAAATACAAAAGGACTTGCTGGTTCTTGAAGAAC AAGAGGGCTCTGTGAATTTCAAGTTTGGGGTTCTTTTTGCCAAAGATGGGCAGCTCACTGATGATGAGATGTTCAGCAATGAAATTGGAA GCGAGCCTTTTCAAAAATTTTTAAATCTTCTGGGTGACACAATCACTCTAAAGGGCTGGACGGGCTACCGTGGCGGTCTGGATACCAAAA ATGATACCACAGGGATACATTCAGTTTATACTGTGTACCAAGGGCATGAGATCATGTTTCATGTTTCCACCATGTTGCCATATTCCAAAG AGAACAAACAGCAGGTGGAAAGGAAACGCCACATTGGAAACGATATCGTCACCATTGTGTTCCAAGAAGGAGAGGAATCTTCTCCTGCCT TTAAGCCTTCCATGATCCGCTCCCACTTTACACATATTTTTGCCTTAGTGAGATACAATCAACAAAATGACAATTACAGGCTGAAAATAT TTTCAGAAGAGAGCGTACCACTCTTTGGCCCTCCCTTGCCAACTCCACCAGTGTTTACAGACCACCAGGAATTCAGGGACTTTTTGCTAG TGAAATTAATTAATGGTGAAAAAGCCACTTTGGAAACCCCAACATTTGCCCAGAAACGTCGGCGTACCCTGGATATGTTGATTAGATCTT TACACCAGGATTTGATGCCAGATTTGCATAAGAACATGCTTAATAGACGATCTTTTAGTGATGTCTTACCAGAGTCACCCAAGTCAGCGC GGAAGAAAGAGGAGGCCCGCCAGGCGGAGTTTGTTAGAATAGGGCAGGCACTAAAACTGAAATCCATTGTGAGAGGGGATGCTCCATCAA GCTTGGCAGCTTCAGGGATCTGTAAAAAAGAGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCT TTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACT GTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATA TTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACT TTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAA ACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCA TTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAG GTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAG TCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTT CATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCAATTAAAACCATTACCTTAAAATTTTTTTCTTTCGAAGTGTG GTGTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATAGATAATAGTACATGTCACCTTAGGTAGTAGGAAGAATTACAATTTCTTTA AATCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGACGGATTATCTAGAGAATAATCATATATATGCATACGTAAAAATG GACCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTTTGTTAGTGCATTTGAGCACACATTTTAATTTTCCTCTAATTAA AATGTGCAGTATTTTCAGTGTCAAATATATTTAACTATTTAGAGAATGATTTCCACCTTTATGTTTTAATATCCTAGGCATCTGCTGTAA TAATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACTAATTTGTATAACCCATATCTGTGCAATGGAATATAAATATCAC AAAGTTGTTTAACTAGACTGCGTGTTGTTTTTCCCGTATAATAAAACCAAAGAATAGTTTGGTTCTTCAAATCTTAAGAGAATCCACATA AAAGAAGAAACTATTTTTTAAAAATTCACTTCTATATATACAATGAGTAAAATCACAGATTTTTTCTTTAAATAAAAATAAGTCATTTTA ATAACTAAACCAGATTCTTTGTGGATACTATTAAAGTAACATTTAAGCCTCAACCTTGAATGATGTTGTTTAATATAAAATGCTTTTATT TTTGATGGAAAGGCAATCAAAGCCTAAAGTTTCCAAGGAACGTAAAATAACTGTGCTTCTCTGAGAATGCCCGCCTCACAAGTGGAACAT TTTGAGTTAATAATGATGATTTTTATGTTTCTAAGGTTGCTTCCTCTCTGAAATAATTCAGAATCCACCCCCATTTAATAAAATACCTAT >In-frame_ENST00000314904_ENST00000378565_TCGA-IN-7808-01A_GARNL3_chr9_130107756_+_ITM2B_chr13_48827944_length(amino acids)=706AA_start in transcript=395_stop in transcript=2515 MQMVVDFCRRFVARSLCIILMKHFCSSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSSDENATALPGTWRRTDVH LENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKG PREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTV YQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQNDNYRLKIFSEESVPLFGPP LPTPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFV RIGQALKLKSIVRGDAPSSLAASGICKKEDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVIL NEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAG -------------------------------------------------------------- >In-frame_ENST00000314904_ENST00000378549_TCGA-IN-7808-01A_GARNL3_chr9_130107756_+_ITM2B_chr13_48827944_length(transcript)=2362nt_BP=1832nt CTCTTACTTAAAATATAGCATTAAATAATGCTGGTTATTTTTATGTTGCATATTTGGGACAAAGAGCTCTCTTAAATGAAAGATAATTGC AAGATCCGGTTCAGCAGCTTTGTCCCTTGCCTCAAGTTTACTGCAGGGCTTCTCTCCTCTCTGGTTATACAGAAATGAAATTATAAACCA CCAGTAACCTTGGAAATTTCAATCGATTCCAAATGACTAAATATTTAATTGAATCATTGCCTATACTTCCAGGGATGACTCTGGCGTTTG CTTTTTATTGAGGGCTCCATGAAAGCCAGGCTCTGCAATGGCTGCTGGGGACTGTGTCTGTTGCAAGGAGGCTCCCCTGCAGTGAGGAGC CGGGGCACTGCAAGTCTGTTCCATAGCAGCCCTTTTTGCAAATGGTAGTTGATTTTTGCAGAAGGTTTGTGGCCAGATCGCTATGTATAA TACTGATGAAGCATTTTTGTTCCAGCTCTGTCTCGGAAGACCTAGGCTGTAGACGTGGGGATTTCAGTAGGAAACATTATGGATCTGTGG AGCTGCTTATTTCCAGTGATGCTGATGGAGCCATCCAAAGGGCTGGAAGATTCAGAGTGGAAAATGGCTCTTCAGATGAGAATGCAACTG CCCTGCCTGGTACTTGGCGAAGAACAGACGTGCACTTAGAGAACCCAGAATACCACACCAGATGGTATTTCAAATATTTTTTAGGACAAG TCCATCAGAACTACATTGGAAACGATGCCGAGAAGAGCCCTTTCTTCTTGTCCGTGACCCTTTCTGACCAAAACAATCAACGTGTCCCTC AATACCGTGCAATTCTTTGGAGAAAAACAGGTACCCAGAAAATATGCCTTCCCTACAGTCCCACAAAAACTCTTTCTGTGAAGTCCATCT TAAGTGCCATGAATCTGGACAAATTTGAGAAAGGCCCCAGGGAAATTTTTCATCCTGAAATACAAAAGGACTTGCTGGTTCTTGAAGAAC AAGAGGGCTCTGTGAATTTCAAGTTTGGGGTTCTTTTTGCCAAAGATGGGCAGCTCACTGATGATGAGATGTTCAGCAATGAAATTGGAA GCGAGCCTTTTCAAAAATTTTTAAATCTTCTGGGTGACACAATCACTCTAAAGGGCTGGACGGGCTACCGTGGCGGTCTGGATACCAAAA ATGATACCACAGGGATACATTCAGTTTATACTGTGTACCAAGGGCATGAGATCATGTTTCATGTTTCCACCATGTTGCCATATTCCAAAG AGAACAAACAGCAGGTGGAAAGGAAACGCCACATTGGAAACGATATCGTCACCATTGTGTTCCAAGAAGGAGAGGAATCTTCTCCTGCCT TTAAGCCTTCCATGATCCGCTCCCACTTTACACATATTTTTGCCTTAGTGAGATACAATCAACAAAATGACAATTACAGGCTGAAAATAT TTTCAGAAGAGAGCGTACCACTCTTTGGCCCTCCCTTGCCAACTCCACCAGTGTTTACAGACCACCAGGAATTCAGGGACTTTTTGCTAG TGAAATTAATTAATGGTGAAAAAGCCACTTTGGAAACCCCAACATTTGCCCAGAAACGTCGGCGTACCCTGGATATGTTGATTAGATCTT TACACCAGGATTTGATGCCAGATTTGCATAAGAACATGCTTAATAGACGATCTTTTAGTGATGTCTTACCAGAGTCACCCAAGTCAGCGC GGAAGAAAGAGGAGGCCCGCCAGGCGGAGTTTGTTAGAATAGGGCAGGCACTAAAACTGAAATCCATTGTGAGAGGGGATGCTCCATCAA GCTTGGCAGCTTCAGGGATCTGTAAAAAAGAGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCT TTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAAGCTGGAACCTATTTGCCTC AGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATG ACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTG AAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCAC CCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTC >In-frame_ENST00000314904_ENST00000378549_TCGA-IN-7808-01A_GARNL3_chr9_130107756_+_ITM2B_chr13_48827944_length(amino acids)=600AA_start in transcript=395_stop in transcript=2197 MQMVVDFCRRFVARSLCIILMKHFCSSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSSDENATALPGTWRRTDVH LENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKG PREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTV YQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQNDNYRLKIFSEESVPLFGPP LPTPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFV RIGQALKLKSIVRGDAPSSLAASGICKKEDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQAGTYLPQSYLIHEHMVIT -------------------------------------------------------------- >In-frame_ENST00000373387_ENST00000378565_TCGA-IN-7808-01A_GARNL3_chr9_130107756_+_ITM2B_chr13_48827944_length(transcript)=3567nt_BP=1783nt ATATTTGGGACAAAGAGCTCTCTTAAATGAAAGATAATTGCAAGATCCGGTTCAGCAGCTTTGTCCCTTGCCTCAAGTTTACTGCAGGGC TTCTCTCCTCTCTGGTTATACAGAAATGAAATTATAAACCACCAGTAACCTTGGAAATTTCAATCGATTCCAAATGACTAAATATTTAAT TGAATCATTGCCTATACTTCCAGGGATGACTCTGGCGTTTGCTTTTTATTGAGGGCTCCATGAAAGCCAGGCTCTGCAATGGCTGCTGGG GACTGTGTCTGTTGCAAGGAGGCTCCCCTGCAGTGAGGAGCCGGGGCACTGCAAGTCTGTTCCATAGCAGCCCTTTTTGCAAATGGTAGT TGATTTTTGCAGAAGGTTTGTGGCCAGATCGCTATGTATAATACTGATGAAGCATTTTTGTTCCAGCTCTGTCTCGGAAGACCTAGGCTG TAGACGTGGGGATTTCAGTAGGAAACATTATGGATCTGTGGAGCTGCTTATTTCCAGTGATGCTGATGGAGCCATCCAAAGGGCTGGAAG ATTCAGAGTGGAAAATGGCTCTTCAGATGAGAATGCAACTGCCCTGCCTGGTACTTGGCGAAGAACAGACGTGCACTTAGAGAACCCAGA ATACCACACCAGATGGTATTTCAAATATTTTTTAGGACAAGTCCATCAGAACTACATTGGAAACGATGCCGAGAAGAGCCCTTTCTTCTT GTCCGTGACCCTTTCTGACCAAAACAATCAACGTGTCCCTCAATACCGTGCAATTCTTTGGAGAAAAACAGGTACCCAGAAAATATGCCT TCCCTACAGTCCCACAAAAACTCTTTCTGTGAAGTCCATCTTAAGTGCCATGAATCTGGACAAATTTGAGAAAGGCCCCAGGGAAATTTT TCATCCTGAAATACAAAAGGACTTGCTGGTTCTTGAAGAACAAGAGGGCTCTGTGAATTTCAAGTTTGGGGTTCTTTTTGCCAAAGATGG GCAGCTCACTGATGATGAGATGTTCAGCAATGAAATTGGAAGCGAGCCTTTTCAAAAATTTTTAAATCTTCTGGGTGACACAATCACTCT AAAGGGCTGGACGGGCTACCGTGGCGGTCTGGATACCAAAAATGATACCACAGGGATACATTCAGTTTATACTGTGTACCAAGGGCATGA GATCATGTTTCATGTTTCCACCATGTTGCCATATTCCAAAGAGAACAAACAGCAGGTGGAAAGGAAACGCCACATTGGAAACGATATCGT CACCATTGTGTTCCAAGAAGGAGAGGAATCTTCTCCTGCCTTTAAGCCTTCCATGATCCGCTCCCACTTTACACATATTTTTGCCTTAGT GAGATACAATCAACAAAATGACAATTACAGGCTGAAAATATTTTCAGAAGAGAGCGTACCACTCTTTGGCCCTCCCTTGCCAACTCCACC AGTGTTTACAGACCACCAGGAATTCAGGGACTTTTTGCTAGTGAAATTAATTAATGGTGAAAAAGCCACTTTGGAAACCCCAACATTTGC CCAGAAACGTCGGCGTACCCTGGATATGTTGATTAGATCTTTACACCAGGATTTGATGCCAGATTTGCATAAGAACATGCTTAATAGACG ATCTTTTAGTGATGTCTTACCAGAGTCACCCAAGTCAGCGCGGAAGAAAGAGGAGGCCCGCCAGGCGGAGTTTGTTAGAATAGGGCAGGC ACTAAAACTGAAATCCATTGTGAGAGGGGATGCTCCATCAAGCTTGGCAGCTTCAGGGATCTGTAAAAAAGAGGACCCAGATGATGTGGT ACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTT GTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGC AGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCC AGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTA TGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCA GTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGA CAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGA AAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACC CTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCA ATTAAAACCATTACCTTAAAATTTTTTTCTTTCGAAGTGTGGTGTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATAGATAATAGT ACATGTCACCTTAGGTAGTAGGAAGAATTACAATTTCTTTAAATCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGACGG ATTATCTAGAGAATAATCATATATATGCATACGTAAAAATGGACCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTTTG TTAGTGCATTTGAGCACACATTTTAATTTTCCTCTAATTAAAATGTGCAGTATTTTCAGTGTCAAATATATTTAACTATTTAGAGAATGA TTTCCACCTTTATGTTTTAATATCCTAGGCATCTGCTGTAATAATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACTAA TTTGTATAACCCATATCTGTGCAATGGAATATAAATATCACAAAGTTGTTTAACTAGACTGCGTGTTGTTTTTCCCGTATAATAAAACCA AAGAATAGTTTGGTTCTTCAAATCTTAAGAGAATCCACATAAAAGAAGAAACTATTTTTTAAAAATTCACTTCTATATATACAATGAGTA AAATCACAGATTTTTTCTTTAAATAAAAATAAGTCATTTTAATAACTAAACCAGATTCTTTGTGGATACTATTAAAGTAACATTTAAGCC TCAACCTTGAATGATGTTGTTTAATATAAAATGCTTTTATTTTTGATGGAAAGGCAATCAAAGCCTAAAGTTTCCAAGGAACGTAAAATA ACTGTGCTTCTCTGAGAATGCCCGCCTCACAAGTGGAACATTTTGAGTTAATAATGATGATTTTTATGTTTCTAAGGTTGCTTCCTCTCT >In-frame_ENST00000373387_ENST00000378565_TCGA-IN-7808-01A_GARNL3_chr9_130107756_+_ITM2B_chr13_48827944_length(amino acids)=706AA_start in transcript=346_stop in transcript=2466 MQMVVDFCRRFVARSLCIILMKHFCSSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSSDENATALPGTWRRTDVH LENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKG PREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTV YQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQNDNYRLKIFSEESVPLFGPP LPTPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFV RIGQALKLKSIVRGDAPSSLAASGICKKEDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVIL NEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAG -------------------------------------------------------------- >In-frame_ENST00000373387_ENST00000378549_TCGA-IN-7808-01A_GARNL3_chr9_130107756_+_ITM2B_chr13_48827944_length(transcript)=2313nt_BP=1783nt ATATTTGGGACAAAGAGCTCTCTTAAATGAAAGATAATTGCAAGATCCGGTTCAGCAGCTTTGTCCCTTGCCTCAAGTTTACTGCAGGGC TTCTCTCCTCTCTGGTTATACAGAAATGAAATTATAAACCACCAGTAACCTTGGAAATTTCAATCGATTCCAAATGACTAAATATTTAAT TGAATCATTGCCTATACTTCCAGGGATGACTCTGGCGTTTGCTTTTTATTGAGGGCTCCATGAAAGCCAGGCTCTGCAATGGCTGCTGGG GACTGTGTCTGTTGCAAGGAGGCTCCCCTGCAGTGAGGAGCCGGGGCACTGCAAGTCTGTTCCATAGCAGCCCTTTTTGCAAATGGTAGT TGATTTTTGCAGAAGGTTTGTGGCCAGATCGCTATGTATAATACTGATGAAGCATTTTTGTTCCAGCTCTGTCTCGGAAGACCTAGGCTG TAGACGTGGGGATTTCAGTAGGAAACATTATGGATCTGTGGAGCTGCTTATTTCCAGTGATGCTGATGGAGCCATCCAAAGGGCTGGAAG ATTCAGAGTGGAAAATGGCTCTTCAGATGAGAATGCAACTGCCCTGCCTGGTACTTGGCGAAGAACAGACGTGCACTTAGAGAACCCAGA ATACCACACCAGATGGTATTTCAAATATTTTTTAGGACAAGTCCATCAGAACTACATTGGAAACGATGCCGAGAAGAGCCCTTTCTTCTT GTCCGTGACCCTTTCTGACCAAAACAATCAACGTGTCCCTCAATACCGTGCAATTCTTTGGAGAAAAACAGGTACCCAGAAAATATGCCT TCCCTACAGTCCCACAAAAACTCTTTCTGTGAAGTCCATCTTAAGTGCCATGAATCTGGACAAATTTGAGAAAGGCCCCAGGGAAATTTT TCATCCTGAAATACAAAAGGACTTGCTGGTTCTTGAAGAACAAGAGGGCTCTGTGAATTTCAAGTTTGGGGTTCTTTTTGCCAAAGATGG GCAGCTCACTGATGATGAGATGTTCAGCAATGAAATTGGAAGCGAGCCTTTTCAAAAATTTTTAAATCTTCTGGGTGACACAATCACTCT AAAGGGCTGGACGGGCTACCGTGGCGGTCTGGATACCAAAAATGATACCACAGGGATACATTCAGTTTATACTGTGTACCAAGGGCATGA GATCATGTTTCATGTTTCCACCATGTTGCCATATTCCAAAGAGAACAAACAGCAGGTGGAAAGGAAACGCCACATTGGAAACGATATCGT CACCATTGTGTTCCAAGAAGGAGAGGAATCTTCTCCTGCCTTTAAGCCTTCCATGATCCGCTCCCACTTTACACATATTTTTGCCTTAGT GAGATACAATCAACAAAATGACAATTACAGGCTGAAAATATTTTCAGAAGAGAGCGTACCACTCTTTGGCCCTCCCTTGCCAACTCCACC AGTGTTTACAGACCACCAGGAATTCAGGGACTTTTTGCTAGTGAAATTAATTAATGGTGAAAAAGCCACTTTGGAAACCCCAACATTTGC CCAGAAACGTCGGCGTACCCTGGATATGTTGATTAGATCTTTACACCAGGATTTGATGCCAGATTTGCATAAGAACATGCTTAATAGACG ATCTTTTAGTGATGTCTTACCAGAGTCACCCAAGTCAGCGCGGAAGAAAGAGGAGGCCCGCCAGGCGGAGTTTGTTAGAATAGGGCAGGC ACTAAAACTGAAATCCATTGTGAGAGGGGATGCTCCATCAAGCTTGGCAGCTTCAGGGATCTGTAAAAAAGAGGACCCAGATGATGTGGT ACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTT GTACAAATATTTTGCACTTCAAGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAA CATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCA GAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAA AAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAA >In-frame_ENST00000373387_ENST00000378549_TCGA-IN-7808-01A_GARNL3_chr9_130107756_+_ITM2B_chr13_48827944_length(amino acids)=600AA_start in transcript=346_stop in transcript=2148 MQMVVDFCRRFVARSLCIILMKHFCSSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSSDENATALPGTWRRTDVH LENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKG PREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTV YQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQNDNYRLKIFSEESVPLFGPP LPTPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFV RIGQALKLKSIVRGDAPSSLAASGICKKEDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQAGTYLPQSYLIHEHMVIT -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for GARNL3-ITM2B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for GARNL3-ITM2B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for GARNL3-ITM2B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ITM2B | C1867773 | CEREBRAL AMYLOID ANGIOPATHY, ITM2B-RELATED, 1 | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
| Tgene | ITM2B | C0020538 | Hypertensive disease | 1 | CTD_human |
| Tgene | ITM2B | C0038454 | Cerebrovascular accident | 1 | GENOMICS_ENGLAND |
| Tgene | ITM2B | C0270790 | Quadriparesis | 1 | GENOMICS_ENGLAND |
| Tgene | ITM2B | C0553692 | Brain hemorrhage | 1 | GENOMICS_ENGLAND |
| Tgene | ITM2B | C0575059 | Spastic tetraparesis | 1 | GENOMICS_ENGLAND |
| Tgene | ITM2B | C0948008 | Ischemic stroke | 1 | GENOMICS_ENGLAND |
| Tgene | ITM2B | C1861735 | Dementia, familial Danish | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
| Tgene | ITM2B | C4015146 | RETINAL DYSTROPHY WITH INNER RETINAL DYSFUNCTION AND GANGLION CELL ABNORMALITIES | 1 | CTD_human;ORPHANET;UNIPROT |
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