Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GAS7-CHMP4A (FusionGDB2 ID:32441)

Fusion Gene Summary for GAS7-CHMP4A

Fusion gene summary

Fusion gene information	Fusion gene name: GAS7-CHMP4A
	Fusion gene ID: 32441
		Hgene	Tgene
	Gene symbol	GAS7	CHMP4A
	Gene ID	8522	128866
	Gene name	growth arrest specific 7	charged multivesicular body protein 4B
	Synonyms	-	C20orf178\|CHMP4A\|CTPP3\|CTRCT31\|SNF7\|SNF7-2\|Shax1\|VPS32B\|Vps32-2\|dJ553F4.4
	Cytomap	17p13.1	20q11.22
	Type of gene	protein-coding	protein-coding
	Description	growth arrest-specific protein 7	charged multivesicular body protein 4bSNF7 homolog associated with Alix 1Snf7 homologue associated with Alix 1chromatin modifying protein 4Bchromatin-modifying protein 4bhSnf7-2hVps32-2vacuolar protein-sorting-associated protein 32-2
	Modification date	20200313	20200313
	UniProtAcc	O60861	Q9BY43
	Ensembl transtripts involved in fusion gene	ENST00000437099, ENST00000323816, ENST00000432992, ENST00000540214, ENST00000585266, ENST00000580865, ENST00000583882, ENST00000542249, ENST00000396115, ENST00000579158, ENST00000578655,	ENST00000347519, ENST00000530996, ENST00000542700, ENST00000609024,
Fusion gene scores	* DoF score	15 X 14 X 7=1470	4 X 3 X 3=36
	# samples	17	4
	** MAII score	log2(17/1470*10)=-3.11220950358603 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: GAS7 [Title/Abstract] AND CHMP4A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GAS7(9923094)-CHMP4A(24681035), # samples:2
Anticipated loss of major functional domain due to fusion event.	GAS7-CHMP4A seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. GAS7-CHMP4A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CHMP4A	GO:0039702	viral budding via host ESCRT complex	24878737
Tgene	CHMP4A	GO:0051258	protein polymerization	18209100

Fusion gene breakpoints across GAS7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CHMP4A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-06-2562-01A	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
ChimerDB4	GBM	TCGA-06-2562-01A	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-

Top

Fusion Gene ORF analysis for GAS7-CHMP4A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000437099	ENST00000347519	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000437099	ENST00000530996	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000437099	ENST00000542700	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000437099	ENST00000609024	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
In-frame	ENST00000323816	ENST00000347519	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000323816	ENST00000530996	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000323816	ENST00000542700	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000323816	ENST00000609024	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
In-frame	ENST00000432992	ENST00000347519	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000432992	ENST00000530996	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000432992	ENST00000542700	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000432992	ENST00000609024	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
Frame-shift	ENST00000540214	ENST00000347519	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000540214	ENST00000530996	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000540214	ENST00000542700	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000540214	ENST00000609024	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
In-frame	ENST00000585266	ENST00000347519	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000585266	ENST00000530996	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000585266	ENST00000542700	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000585266	ENST00000609024	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
intron-3CDS	ENST00000580865	ENST00000347519	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
intron-5UTR	ENST00000580865	ENST00000530996	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
intron-5UTR	ENST00000580865	ENST00000542700	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
intron-5UTR	ENST00000580865	ENST00000609024	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
intron-3CDS	ENST00000583882	ENST00000347519	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
intron-5UTR	ENST00000583882	ENST00000530996	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
intron-5UTR	ENST00000583882	ENST00000542700	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
intron-5UTR	ENST00000583882	ENST00000609024	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
Frame-shift	ENST00000542249	ENST00000347519	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000542249	ENST00000530996	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000542249	ENST00000542700	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000542249	ENST00000609024	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
In-frame	ENST00000396115	ENST00000347519	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000396115	ENST00000530996	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000396115	ENST00000542700	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000396115	ENST00000609024	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
Frame-shift	ENST00000579158	ENST00000347519	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000579158	ENST00000530996	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000579158	ENST00000542700	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5CDS-5UTR	ENST00000579158	ENST00000609024	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5UTR-3CDS	ENST00000578655	ENST00000347519	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5UTR-5UTR	ENST00000578655	ENST00000530996	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5UTR-5UTR	ENST00000578655	ENST00000542700	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-
5UTR-5UTR	ENST00000578655	ENST00000609024	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000437099	GAS7	chr17	9923094	-	ENST00000347519	CHMP4A	chr14	24681035	-	1189	257	145	894	249
ENST00000323816	GAS7	chr17	9923094	-	ENST00000347519	CHMP4A	chr14	24681035	-	1219	287	145	924	259
ENST00000432992	GAS7	chr17	9923094	-	ENST00000347519	CHMP4A	chr14	24681035	-	1397	465	80	1102	340
ENST00000585266	GAS7	chr17	9923094	-	ENST00000347519	CHMP4A	chr14	24681035	-	1367	435	308	1072	254
ENST00000396115	GAS7	chr17	9923094	-	ENST00000347519	CHMP4A	chr14	24681035	-	1189	257	145	894	249

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000437099	ENST00000347519	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-	0.001875288	0.99812466
ENST00000323816	ENST00000347519	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-	0.002192571	0.99780744
ENST00000432992	ENST00000347519	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-	0.005275761	0.9947242
ENST00000585266	ENST00000347519	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-	0.001920475	0.99807954
ENST00000396115	ENST00000347519	GAS7	chr17	9923094	-	CHMP4A	chr14	24681035	-	0.001875288	0.99812466

Top

Fusion Genomic Features for GAS7-CHMP4A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for GAS7-CHMP4A

Go to
FGviewer for the breakpoints of chr17:9923094-chr14:24681035
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GAS7 O60861	CHMP4A Q9BY43
FUNCTION: May play a role in promoting maturation and morphological differentiation of cerebellar neurons.	FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269\|PubMed:12860994, ECO:0000269\|PubMed:14505569, ECO:0000269\|PubMed:14519844, ECO:0000269\|PubMed:14583093, ECO:0000269\|PubMed:18209100, ECO:0000269\|PubMed:22660413}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000432992

67_70

101.33333333333333

477.0

Compositional bias

Note=Poly-Pro

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000432992

1_62

101.33333333333333

477.0

Domain

SH3

Tgene

CHMP4A

chr17:9923094

chr14:24681035

ENST00000347519

155_180

53.333333333333336

266.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CHMP4A

chr17:9923094

chr14:24681035

ENST00000609024

155_180

10.333333333333334

223.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CHMP4A

chr17:9923094

chr14:24681035

ENST00000609024

20_105

10.333333333333334

223.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000323816

309_419

41.333333333333336

417.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000396115

309_419

37.333333333333336

182.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000432992

309_419

101.33333333333333

477.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000437099

309_419

37.333333333333336

413.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000580865

309_419

337.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000585266

309_419

41.333333333333336

417.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000323816

67_70

41.333333333333336

417.0

Compositional bias

Note=Poly-Pro

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000396115

67_70

37.333333333333336

182.0

Compositional bias

Note=Poly-Pro

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000437099

67_70

37.333333333333336

413.0

Compositional bias

Note=Poly-Pro

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000580865

67_70

337.0

Compositional bias

Note=Poly-Pro

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000585266

67_70

41.333333333333336

417.0

Compositional bias

Note=Poly-Pro

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000323816

196_456

41.333333333333336

417.0

Domain

F-BAR

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000323816

1_62

41.333333333333336

417.0

Domain

SH3

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000323816

77_110

41.333333333333336

417.0

Domain

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000396115

196_456

37.333333333333336

182.0

Domain

F-BAR

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000396115

1_62

37.333333333333336

182.0

Domain

SH3

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000396115

77_110

37.333333333333336

182.0

Domain

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000432992

196_456

101.33333333333333

477.0

Domain

F-BAR

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000432992

77_110

101.33333333333333

477.0

Domain

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000437099

196_456

37.333333333333336

413.0

Domain

F-BAR

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000437099

1_62

37.333333333333336

413.0

Domain

SH3

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000437099

77_110

37.333333333333336

413.0

Domain

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000580865

196_456

337.0

Domain

F-BAR

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000580865

1_62

337.0

Domain

SH3

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000580865

77_110

337.0

Domain

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000585266

196_456

41.333333333333336

417.0

Domain

F-BAR

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000585266

1_62

41.333333333333336

417.0

Domain

SH3

Hgene

GAS7

chr17:9923094

chr14:24681035

ENST00000585266

77_110

41.333333333333336

417.0

Domain

Tgene

CHMP4A

chr17:9923094

chr14:24681035

ENST00000347519

20_105

53.333333333333336

266.0

Coiled coil

Ontology_term=ECO:0000255

Top

Fusion Gene Sequence for GAS7-CHMP4A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000437099_ENST00000347519_TCGA-06-2562-01A_GAS7_chr17_9923094_-_CHMP4A_chr14_24681035_length(transcript)=1189nt_BP=257nt
ATTGCTTCTGGGTTTGGGGTGTGAGAGGATGCAGAGTGGGAGACCTTAAAACCGTCTGATCTGGCTGCTAAAGCGAGTGTCTGACGACCA
CCCATTAACACCAGCGAGTAGCGTTTGCTCACGGCTTTAGGATAAGAAGCCTGGAATGGTCCCCCCTCCGCCGGGAGAAGAAAGCCAGAC
GGTCATCCTTCCACCTGGCTGGCAGAGCTACCTGTCGCCTCAGGGCCGGCGGTACTATGTCAACACGACCACCAATGGGAAGAAGGAGAA
AGGGCCAACCCCTGAAGAAGCAATACAGAAACTGAAGGAGACAGAGAAGATACTGATCAAGAAACAGGAATTTTTGGAGCAGAAGATTCA
ACAGGAGCTACAAACAGCCAAGAAGTATGGGACCAAGAATAAGAGAGCTGCCCTACAGGCTTTGCGGAGGAAGAAAAGATTCGAACAGCA
GCTGGCACAAACTGACGGGACATTATCCACCCTGGAGTTTCAGCGTGAGGCCATTGAGAATGCCACTACCAATGCAGAAGTCCTTCGTAC
CATGGAGCTTGCTGCCCAAAGCATGAAGAAGGCCTACCAGGACATGGACATTGACAAGGTAGATGAACTGATGACTGACATCACGGAACA
ACAGGAGGTGGCCCAGCAGATCTCAGATGCCATTTCTCGGCCTATGGGCTTTGGAGATGATGTGGATGAGGATGAACTGCTGGAGGAGCT
AGAGGAGCTGGAGCAGGAGGAATTGGCCCAGGAGTTGTTAAATGTGGGCGACAAGGAAGAAGAACCCTCAGTCAAATTGCCTAGTGTACC
TTCTACTCATCTGCCGGCAGGGCCAGCTCCCAAAGTGGATGAAGATGAAGAAGCACTAAAGCAGTTGGCTGAGTGGGTATCCTGATAAAT
CTGGGCTTGTCTTCCTAATGCTACCTTTGTTGGTCCTTTCTTCCTTAAGTGCCAAGTGCTGAGCTAAAGGAGGATAACTTTTTGGGGAAG
TCATGCTGAGGGTGGTAGTGTGACCCTGCCTGAAAAAAGGGTCTCTTACCCTCCCAGCCCTGGCTCAACTCTGAAGAAGGATCTTGCTAC
AGAAGGAGCCCTTGGGCTCCCTTCTCTTTGATAGCAGTTATAATGCCCTTGTTCCCAATAAAACTGGGCAGATGGAATCCTAGTGTCTAT

>In-frame_ENST00000437099_ENST00000347519_TCGA-06-2562-01A_GAS7_chr17_9923094_-_CHMP4A_chr14_24681035_length(amino acids)=249AA_start in transcript=145_stop in transcript=894
MVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNGKKEKGPTPEEAIQKLKETEKILIKKQEFLEQKIQQELQTAKKYGTKNKRAAL
QALRRKKRFEQQLAQTDGTLSTLEFQREAIENATTNAEVLRTMELAAQSMKKAYQDMDIDKVDELMTDITEQQEVAQQISDAISRPMGFG

--------------------------------------------------------------
>In-frame_ENST00000323816_ENST00000347519_TCGA-06-2562-01A_GAS7_chr17_9923094_-_CHMP4A_chr14_24681035_length(transcript)=1219nt_BP=287nt
GATTTTCTTCCCTGGAGTGAGAAGCAGGCAGAGGATCACTCGGTGGCTGTGTATACCCTGCCTTTGGTGGTGGCACCCCAGTCAGAAACG
GGACCCTGAAGCTGGGATTTAGGATGCTGGCTGTGTCACCTCGGTCTCCCCAAGATTGAACGCAAGACGAGCCATGAAGCCTGGAATGGT
CCCCCCTCCGCCGGGAGAAGAAAGCCAGACGGTCATCCTTCCACCTGGCTGGCAGAGCTACCTGTCGCCTCAGGGCCGGCGGTACTATGT
CAACACGACCACCAATGGGAAGAAGGAGAAAGGGCCAACCCCTGAAGAAGCAATACAGAAACTGAAGGAGACAGAGAAGATACTGATCAA
GAAACAGGAATTTTTGGAGCAGAAGATTCAACAGGAGCTACAAACAGCCAAGAAGTATGGGACCAAGAATAAGAGAGCTGCCCTACAGGC
TTTGCGGAGGAAGAAAAGATTCGAACAGCAGCTGGCACAAACTGACGGGACATTATCCACCCTGGAGTTTCAGCGTGAGGCCATTGAGAA
TGCCACTACCAATGCAGAAGTCCTTCGTACCATGGAGCTTGCTGCCCAAAGCATGAAGAAGGCCTACCAGGACATGGACATTGACAAGGT
AGATGAACTGATGACTGACATCACGGAACAACAGGAGGTGGCCCAGCAGATCTCAGATGCCATTTCTCGGCCTATGGGCTTTGGAGATGA
TGTGGATGAGGATGAACTGCTGGAGGAGCTAGAGGAGCTGGAGCAGGAGGAATTGGCCCAGGAGTTGTTAAATGTGGGCGACAAGGAAGA
AGAACCCTCAGTCAAATTGCCTAGTGTACCTTCTACTCATCTGCCGGCAGGGCCAGCTCCCAAAGTGGATGAAGATGAAGAAGCACTAAA
GCAGTTGGCTGAGTGGGTATCCTGATAAATCTGGGCTTGTCTTCCTAATGCTACCTTTGTTGGTCCTTTCTTCCTTAAGTGCCAAGTGCT
GAGCTAAAGGAGGATAACTTTTTGGGGAAGTCATGCTGAGGGTGGTAGTGTGACCCTGCCTGAAAAAAGGGTCTCTTACCCTCCCAGCCC
TGGCTCAACTCTGAAGAAGGATCTTGCTACAGAAGGAGCCCTTGGGCTCCCTTCTCTTTGATAGCAGTTATAATGCCCTTGTTCCCAATA

>In-frame_ENST00000323816_ENST00000347519_TCGA-06-2562-01A_GAS7_chr17_9923094_-_CHMP4A_chr14_24681035_length(amino acids)=259AA_start in transcript=145_stop in transcript=924
MNARRAMKPGMVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNGKKEKGPTPEEAIQKLKETEKILIKKQEFLEQKIQQELQTAKK
YGTKNKRAALQALRRKKRFEQQLAQTDGTLSTLEFQREAIENATTNAEVLRTMELAAQSMKKAYQDMDIDKVDELMTDITEQQEVAQQIS

--------------------------------------------------------------
>In-frame_ENST00000432992_ENST00000347519_TCGA-06-2562-01A_GAS7_chr17_9923094_-_CHMP4A_chr14_24681035_length(transcript)=1397nt_BP=465nt
GTCCCCCGCCTGCCTGAGGACCCCCGCGCACCCCAGAGACGGCGCGCGCCCAGAGCGCGGGAGCCCGGAGCGCCGGGCGCCTGGGACCCC
GCGGAGCCGCTGCCCAGCCCGTGGGGCTCGGCGGGAATGCAGGCTGCGCTGTGAACCCGGGCGCCAAGGCCATGTCCGGCGCTCGCTGCC
GGACCCTGTACCCCTTCTCCGGGGAGCGGCACGGCCAGGGGCTGCGCTTCGCCGCGGGCGAGCTGATCACGCTGCTGCAGGTCCCGGACG
GCGGCTGGTGGGAAGGCGAGAAGGAGGACGGGCTCCGTGGCTGGTTCCCGGCGAGCTACGTGCAGTTGCTGGAGAAGCCTGGAATGGTCC
CCCCTCCGCCGGGAGAAGAAAGCCAGACGGTCATCCTTCCACCTGGCTGGCAGAGCTACCTGTCGCCTCAGGGCCGGCGGTACTATGTCA
ACACGACCACCAATGGGAAGAAGGAGAAAGGGCCAACCCCTGAAGAAGCAATACAGAAACTGAAGGAGACAGAGAAGATACTGATCAAGA
AACAGGAATTTTTGGAGCAGAAGATTCAACAGGAGCTACAAACAGCCAAGAAGTATGGGACCAAGAATAAGAGAGCTGCCCTACAGGCTT
TGCGGAGGAAGAAAAGATTCGAACAGCAGCTGGCACAAACTGACGGGACATTATCCACCCTGGAGTTTCAGCGTGAGGCCATTGAGAATG
CCACTACCAATGCAGAAGTCCTTCGTACCATGGAGCTTGCTGCCCAAAGCATGAAGAAGGCCTACCAGGACATGGACATTGACAAGGTAG
ATGAACTGATGACTGACATCACGGAACAACAGGAGGTGGCCCAGCAGATCTCAGATGCCATTTCTCGGCCTATGGGCTTTGGAGATGATG
TGGATGAGGATGAACTGCTGGAGGAGCTAGAGGAGCTGGAGCAGGAGGAATTGGCCCAGGAGTTGTTAAATGTGGGCGACAAGGAAGAAG
AACCCTCAGTCAAATTGCCTAGTGTACCTTCTACTCATCTGCCGGCAGGGCCAGCTCCCAAAGTGGATGAAGATGAAGAAGCACTAAAGC
AGTTGGCTGAGTGGGTATCCTGATAAATCTGGGCTTGTCTTCCTAATGCTACCTTTGTTGGTCCTTTCTTCCTTAAGTGCCAAGTGCTGA
GCTAAAGGAGGATAACTTTTTGGGGAAGTCATGCTGAGGGTGGTAGTGTGACCCTGCCTGAAAAAAGGGTCTCTTACCCTCCCAGCCCTG
GCTCAACTCTGAAGAAGGATCTTGCTACAGAAGGAGCCCTTGGGCTCCCTTCTCTTTGATAGCAGTTATAATGCCCTTGTTCCCAATAAA

>In-frame_ENST00000432992_ENST00000347519_TCGA-06-2562-01A_GAS7_chr17_9923094_-_CHMP4A_chr14_24681035_length(amino acids)=340AA_start in transcript=80_stop in transcript=1102
MGPRGAAAQPVGLGGNAGCAVNPGAKAMSGARCRTLYPFSGERHGQGLRFAAGELITLLQVPDGGWWEGEKEDGLRGWFPASYVQLLEKP
GMVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNGKKEKGPTPEEAIQKLKETEKILIKKQEFLEQKIQQELQTAKKYGTKNKRAA
LQALRRKKRFEQQLAQTDGTLSTLEFQREAIENATTNAEVLRTMELAAQSMKKAYQDMDIDKVDELMTDITEQQEVAQQISDAISRPMGF

--------------------------------------------------------------
>In-frame_ENST00000585266_ENST00000347519_TCGA-06-2562-01A_GAS7_chr17_9923094_-_CHMP4A_chr14_24681035_length(transcript)=1367nt_BP=435nt
AGAAACATTGCATCTGGAAAGTCCAGAACAAGTTGTTAATTTCCCAGCAAGCACTGGAGCGGATTTGGAAGGAACTATGCAATGTAGTGG
GTTCTTTGTGAAAGAACAGCAATGAGCAAAGCCACAGGAACCTCCGCTGGGGTGCCCAGAACACTGGCCCTGGGCTAGCGACTTGCCTCA
GCCCCATTTCCCGGAGAGGCTGCCATGAAGAGGAAGCCGGCGGAGTCTTGGTGCTGAGTCTGAGGGCTTCAGGCAGGACCCAAGACTCTC
CTCTGAGGTAGCAGCCCCCAGAGAAGGTTAGCTGTTCTCTGATGAAGCCTGGAATGGTCCCCCCTCCGCCGGGAGAAGAAAGCCAGACGG
TCATCCTTCCACCTGGCTGGCAGAGCTACCTGTCGCCTCAGGGCCGGCGGTACTATGTCAACACGACCACCAATGGGAAGAAGGAGAAAG
GGCCAACCCCTGAAGAAGCAATACAGAAACTGAAGGAGACAGAGAAGATACTGATCAAGAAACAGGAATTTTTGGAGCAGAAGATTCAAC
AGGAGCTACAAACAGCCAAGAAGTATGGGACCAAGAATAAGAGAGCTGCCCTACAGGCTTTGCGGAGGAAGAAAAGATTCGAACAGCAGC
TGGCACAAACTGACGGGACATTATCCACCCTGGAGTTTCAGCGTGAGGCCATTGAGAATGCCACTACCAATGCAGAAGTCCTTCGTACCA
TGGAGCTTGCTGCCCAAAGCATGAAGAAGGCCTACCAGGACATGGACATTGACAAGGTAGATGAACTGATGACTGACATCACGGAACAAC
AGGAGGTGGCCCAGCAGATCTCAGATGCCATTTCTCGGCCTATGGGCTTTGGAGATGATGTGGATGAGGATGAACTGCTGGAGGAGCTAG
AGGAGCTGGAGCAGGAGGAATTGGCCCAGGAGTTGTTAAATGTGGGCGACAAGGAAGAAGAACCCTCAGTCAAATTGCCTAGTGTACCTT
CTACTCATCTGCCGGCAGGGCCAGCTCCCAAAGTGGATGAAGATGAAGAAGCACTAAAGCAGTTGGCTGAGTGGGTATCCTGATAAATCT
GGGCTTGTCTTCCTAATGCTACCTTTGTTGGTCCTTTCTTCCTTAAGTGCCAAGTGCTGAGCTAAAGGAGGATAACTTTTTGGGGAAGTC
ATGCTGAGGGTGGTAGTGTGACCCTGCCTGAAAAAAGGGTCTCTTACCCTCCCAGCCCTGGCTCAACTCTGAAGAAGGATCTTGCTACAG
AAGGAGCCCTTGGGCTCCCTTCTCTTTGATAGCAGTTATAATGCCCTTGTTCCCAATAAAACTGGGCAGATGGAATCCTAGTGTCTATAC

>In-frame_ENST00000585266_ENST00000347519_TCGA-06-2562-01A_GAS7_chr17_9923094_-_CHMP4A_chr14_24681035_length(amino acids)=254AA_start in transcript=308_stop in transcript=1072
MMKPGMVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNGKKEKGPTPEEAIQKLKETEKILIKKQEFLEQKIQQELQTAKKYGTKN
KRAALQALRRKKRFEQQLAQTDGTLSTLEFQREAIENATTNAEVLRTMELAAQSMKKAYQDMDIDKVDELMTDITEQQEVAQQISDAISR

--------------------------------------------------------------
>In-frame_ENST00000396115_ENST00000347519_TCGA-06-2562-01A_GAS7_chr17_9923094_-_CHMP4A_chr14_24681035_length(transcript)=1189nt_BP=257nt
ATTGCTTCTGGGTTTGGGGTGTGAGAGGATGCAGAGTGGGAGACCTTAAAACCGTCTGATCTGGCTGCTAAAGCGAGTGTCTGACGACCA
CCCATTAACACCAGCGAGTAGCGTTTGCTCACGGCTTTAGGATAAGAAGCCTGGAATGGTCCCCCCTCCGCCGGGAGAAGAAAGCCAGAC
GGTCATCCTTCCACCTGGCTGGCAGAGCTACCTGTCGCCTCAGGGCCGGCGGTACTATGTCAACACGACCACCAATGGGAAGAAGGAGAA
AGGGCCAACCCCTGAAGAAGCAATACAGAAACTGAAGGAGACAGAGAAGATACTGATCAAGAAACAGGAATTTTTGGAGCAGAAGATTCA
ACAGGAGCTACAAACAGCCAAGAAGTATGGGACCAAGAATAAGAGAGCTGCCCTACAGGCTTTGCGGAGGAAGAAAAGATTCGAACAGCA
GCTGGCACAAACTGACGGGACATTATCCACCCTGGAGTTTCAGCGTGAGGCCATTGAGAATGCCACTACCAATGCAGAAGTCCTTCGTAC
CATGGAGCTTGCTGCCCAAAGCATGAAGAAGGCCTACCAGGACATGGACATTGACAAGGTAGATGAACTGATGACTGACATCACGGAACA
ACAGGAGGTGGCCCAGCAGATCTCAGATGCCATTTCTCGGCCTATGGGCTTTGGAGATGATGTGGATGAGGATGAACTGCTGGAGGAGCT
AGAGGAGCTGGAGCAGGAGGAATTGGCCCAGGAGTTGTTAAATGTGGGCGACAAGGAAGAAGAACCCTCAGTCAAATTGCCTAGTGTACC
TTCTACTCATCTGCCGGCAGGGCCAGCTCCCAAAGTGGATGAAGATGAAGAAGCACTAAAGCAGTTGGCTGAGTGGGTATCCTGATAAAT
CTGGGCTTGTCTTCCTAATGCTACCTTTGTTGGTCCTTTCTTCCTTAAGTGCCAAGTGCTGAGCTAAAGGAGGATAACTTTTTGGGGAAG
TCATGCTGAGGGTGGTAGTGTGACCCTGCCTGAAAAAAGGGTCTCTTACCCTCCCAGCCCTGGCTCAACTCTGAAGAAGGATCTTGCTAC
AGAAGGAGCCCTTGGGCTCCCTTCTCTTTGATAGCAGTTATAATGCCCTTGTTCCCAATAAAACTGGGCAGATGGAATCCTAGTGTCTAT

>In-frame_ENST00000396115_ENST00000347519_TCGA-06-2562-01A_GAS7_chr17_9923094_-_CHMP4A_chr14_24681035_length(amino acids)=249AA_start in transcript=145_stop in transcript=894
MVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNGKKEKGPTPEEAIQKLKETEKILIKKQEFLEQKIQQELQTAKKYGTKNKRAAL
QALRRKKRFEQQLAQTDGTLSTLEFQREAIENATTNAEVLRTMELAAQSMKKAYQDMDIDKVDELMTDITEQQEVAQQISDAISRPMGFG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GAS7-CHMP4A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	CHMP4A	chr17:9923094	chr14:24681035	ENST00000347519		0	6	1_116	53.333333333333336	266.0	phosphoinosides
Tgene	CHMP4A	chr17:9923094	chr14:24681035	ENST00000609024		0	6	1_116	10.333333333333334	223.0	phosphoinosides

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GAS7-CHMP4A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GAS7-CHMP4A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	GAS7	C0028754	Obesity	1	CTD_human