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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GFAP-IPO8 (FusionGDB2 ID:32807)

Fusion Gene Summary for GFAP-IPO8

check button Fusion gene summary
Fusion gene informationFusion gene name: GFAP-IPO8
Fusion gene ID: 32807
HgeneTgene
Gene symbol

GFAP

IPO8

Gene ID

2670

10526

Gene nameglial fibrillary acidic proteinimportin 8
SynonymsALXDRDRANBP8
Cytomap

17q21.31

12p11.21

Type of geneprotein-codingprotein-coding
Descriptionglial fibrillary acidic proteinimportin-8RAN binding protein 8imp8ran-binding protein 8
Modification date2020032720200313
UniProtAcc.

O15397

Ensembl transtripts involved in fusion geneENST00000253408, ENST00000588735, 
ENST00000435360, ENST00000586793, 
ENST00000591327, 		ENST00000256079, 
ENST00000544829, ENST00000538338, 
Fusion gene scores* DoF score28 X 17 X 2=9523 X 3 X 3=27
# samples 293
** MAII scorelog2(29/952*10)=-1.71490867329301
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GFAP [Title/Abstract] AND IPO8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGFAP(42991395)-IPO8(30823919), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGFAP

GO:0045109

intermediate filament organization

15732097


check buttonFusion gene breakpoints across GFAP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IPO8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DB-5279GFAPchr17

42991395

-IPO8chr12

30823919

-


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Fusion Gene ORF analysis for GFAP-IPO8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000253408ENST00000256079GFAPchr17

42991395

-IPO8chr12

30823919

-
In-frameENST00000253408ENST00000544829GFAPchr17

42991395

-IPO8chr12

30823919

-
5CDS-intronENST00000253408ENST00000538338GFAPchr17

42991395

-IPO8chr12

30823919

-
intron-3CDSENST00000588735ENST00000256079GFAPchr17

42991395

-IPO8chr12

30823919

-
intron-3CDSENST00000588735ENST00000544829GFAPchr17

42991395

-IPO8chr12

30823919

-
intron-intronENST00000588735ENST00000538338GFAPchr17

42991395

-IPO8chr12

30823919

-
In-frameENST00000435360ENST00000256079GFAPchr17

42991395

-IPO8chr12

30823919

-
In-frameENST00000435360ENST00000544829GFAPchr17

42991395

-IPO8chr12

30823919

-
5CDS-intronENST00000435360ENST00000538338GFAPchr17

42991395

-IPO8chr12

30823919

-
In-frameENST00000586793ENST00000256079GFAPchr17

42991395

-IPO8chr12

30823919

-
In-frameENST00000586793ENST00000544829GFAPchr17

42991395

-IPO8chr12

30823919

-
5CDS-intronENST00000586793ENST00000538338GFAPchr17

42991395

-IPO8chr12

30823919

-
intron-3CDSENST00000591327ENST00000256079GFAPchr17

42991395

-IPO8chr12

30823919

-
intron-3CDSENST00000591327ENST00000544829GFAPchr17

42991395

-IPO8chr12

30823919

-
intron-intronENST00000591327ENST00000538338GFAPchr17

42991395

-IPO8chr12

30823919

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000253408GFAPchr1742991395-ENST00000256079IPO8chr1230823919-455458866704212
ENST00000253408GFAPchr1742991395-ENST00000544829IPO8chr1230823919-307058866704212
ENST00000435360GFAPchr1742991395-ENST00000256079IPO8chr1230823919-44965308646212
ENST00000435360GFAPchr1742991395-ENST00000544829IPO8chr1230823919-30125308646212
ENST00000586793GFAPchr1742991395-ENST00000256079IPO8chr1230823919-44965308646212
ENST00000586793GFAPchr1742991395-ENST00000544829IPO8chr1230823919-30125308646212

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000253408ENST00000256079GFAPchr1742991395-IPO8chr1230823919-0.0014977630.99850225
ENST00000253408ENST00000544829GFAPchr1742991395-IPO8chr1230823919-0.0026961060.99730384
ENST00000435360ENST00000256079GFAPchr1742991395-IPO8chr1230823919-0.0014366520.99856335
ENST00000435360ENST00000544829GFAPchr1742991395-IPO8chr1230823919-0.0026265780.99737346
ENST00000586793ENST00000256079GFAPchr1742991395-IPO8chr1230823919-0.0014366520.99856335
ENST00000586793ENST00000544829GFAPchr1742991395-IPO8chr1230823919-0.0026265780.99737346

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Fusion Genomic Features for GFAP-IPO8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GFAP-IPO8


check button Go to

FGviewer for the breakpoints of chr17:42991395-chr12:30823919

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IPO8

O15397

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. {ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9214382}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGFAPchr17:42991395chr12:30823919ENST00000253408-29105_115174.0433.0RegionNote=Linker 1
HgeneGFAPchr17:42991395chr12:30823919ENST00000253408-291_72174.0433.0RegionNote=Head
HgeneGFAPchr17:42991395chr12:30823919ENST00000253408-2973_104174.0433.0RegionNote=Coil 1A
HgeneGFAPchr17:42991395chr12:30823919ENST00000435360-28105_115174.0432.0RegionNote=Linker 1
HgeneGFAPchr17:42991395chr12:30823919ENST00000435360-281_72174.0432.0RegionNote=Head
HgeneGFAPchr17:42991395chr12:30823919ENST00000435360-2873_104174.0432.0RegionNote=Coil 1A
HgeneGFAPchr17:42991395chr12:30823919ENST00000586793-27105_115174.0439.0RegionNote=Linker 1
HgeneGFAPchr17:42991395chr12:30823919ENST00000586793-271_72174.0439.0RegionNote=Head
HgeneGFAPchr17:42991395chr12:30823919ENST00000586793-2773_104174.0439.0RegionNote=Coil 1A
TgeneIPO8chr17:42991395chr12:30823919ENST00000256079025923_92801038.0Compositional biasNote=Poly-Glu
TgeneIPO8chr17:42991395chr12:30823919ENST00000544829021923_9280833.0Compositional biasNote=Poly-Glu
TgeneIPO8chr17:42991395chr12:30823919ENST0000025607902522_10201038.0DomainImportin N-terminal
TgeneIPO8chr17:42991395chr12:30823919ENST0000054482902122_1020833.0DomainImportin N-terminal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGFAPchr17:42991395chr12:30823919ENST00000253408-2969_377174.0433.0DomainIF rod
HgeneGFAPchr17:42991395chr12:30823919ENST00000435360-2869_377174.0432.0DomainIF rod
HgeneGFAPchr17:42991395chr12:30823919ENST00000586793-2769_377174.0439.0DomainIF rod
HgeneGFAPchr17:42991395chr12:30823919ENST00000253408-29116_214174.0433.0RegionNote=Coil 1B
HgeneGFAPchr17:42991395chr12:30823919ENST00000253408-29215_230174.0433.0RegionNote=Linker 12
HgeneGFAPchr17:42991395chr12:30823919ENST00000253408-29231_252174.0433.0RegionNote=Coil 2A
HgeneGFAPchr17:42991395chr12:30823919ENST00000253408-29253_256174.0433.0RegionNote=Linker 2
HgeneGFAPchr17:42991395chr12:30823919ENST00000253408-29257_377174.0433.0RegionNote=Coil 2B
HgeneGFAPchr17:42991395chr12:30823919ENST00000253408-29378_432174.0433.0RegionNote=Tail
HgeneGFAPchr17:42991395chr12:30823919ENST00000435360-28116_214174.0432.0RegionNote=Coil 1B
HgeneGFAPchr17:42991395chr12:30823919ENST00000435360-28215_230174.0432.0RegionNote=Linker 12
HgeneGFAPchr17:42991395chr12:30823919ENST00000435360-28231_252174.0432.0RegionNote=Coil 2A
HgeneGFAPchr17:42991395chr12:30823919ENST00000435360-28253_256174.0432.0RegionNote=Linker 2
HgeneGFAPchr17:42991395chr12:30823919ENST00000435360-28257_377174.0432.0RegionNote=Coil 2B
HgeneGFAPchr17:42991395chr12:30823919ENST00000435360-28378_432174.0432.0RegionNote=Tail
HgeneGFAPchr17:42991395chr12:30823919ENST00000586793-27116_214174.0439.0RegionNote=Coil 1B
HgeneGFAPchr17:42991395chr12:30823919ENST00000586793-27215_230174.0439.0RegionNote=Linker 12
HgeneGFAPchr17:42991395chr12:30823919ENST00000586793-27231_252174.0439.0RegionNote=Coil 2A
HgeneGFAPchr17:42991395chr12:30823919ENST00000586793-27253_256174.0439.0RegionNote=Linker 2
HgeneGFAPchr17:42991395chr12:30823919ENST00000586793-27257_377174.0439.0RegionNote=Coil 2B
HgeneGFAPchr17:42991395chr12:30823919ENST00000586793-27378_432174.0439.0RegionNote=Tail


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Fusion Gene Sequence for GFAP-IPO8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000253408_ENST00000256079_TCGA-DB-5279_GFAP_chr17_42991395_-_IPO8_chr12_30823919_length(transcript)=4554nt_BP=588nt
ATCGCCAGTCTAGCCCACTCCTTCATAAAGCCCTCGCATCCCAGGAGCGAGCAGAGCCAGAGCAGGATGGAGAGGAGACGCATCACCTCC
GCTGCTCGCCGCTCCTACGTCTCCTCAGGGGAGATGATGGTGGGGGGCCTGGCTCCTGGCCGCCGTCTGGGTCCTGGCACCCGCCTCTCC
CTGGCTCGAATGCCCCCTCCACTCCCGACCCGGGTGGATTTCTCCCTGGCTGGGGCACTCAATGCTGGCTTCAAGGAGACCCGGGCCAGT
GAGCGGGCAGAGATGATGGAGCTCAATGACCGCTTTGCCAGCTACATCGAGAAGGTTCGCTTCCTGGAACAGCAAAACAAGGCGCTGGCT
GCTGAGCTGAACCAGCTGCGGGCCAAGGAGCCCACCAAGCTGGCAGACGTCTACCAGGCTGAGCTGCGAGAGCTGCGGCTGCGGCTCGAT
CAACTCACCGCCAACAGCGCCCGGCTGGAGGTTGAGAGGGACAATCTGGCACAGGACCTGGCCACTGTGAGGCAGAAGCTCCAGGATGAA
ACCAACCTGAGGCTGGAAGCCGAGAACAACCTGGCTGCCTATAGACAGAGGCAAAGAAGAAGATTGAACAACAGGGAGGCTTCACCTTTG
AAAACAAAGGAGTCCTCTCCGCATTTAATTTTGGGACTGTGCCCAGCAACAACTGAAGGAAAGAACATCAGCTGACCAAATGTCATCGCT
GCATTTTATTTCACAAGAGGAGTGTGAGGGTCAAGGGGATGAAATGAGGGGCTGCTTTTAGGGCCCTCCTGCTGTGCCAGTTACCATCTG
GCATTAGGCAGCACTTTTATCTACTCTTTCCCCTTTGACCTTTGTCACCCTGAAATATATATTTTAAACAGCTACTGTAAGTATGAAATG
AAAGAAAAACAATCATTGGACGGAAAAGGACAACCCATATGTTCCAAAGGCTGAATGCCCAAGGTTGTTTTAGAGGATTGGATAGACTTG
CACGTCTCAGGTTTTTGCCATGCAGAATCAATGGATTTATGCGGATAACAGTGCCTTCTGTTGTACATGAATTATCAGAAAAAAATTTTT
GGAGTGCATTGCAATTTTTTTTAAAGCATAAAACATATTTCTAGATACAACATAAACCTTGGTTATATGTCAACTATTCTGCATTTTACT
CTGTGAATTTATTGTTAGGCAGTTACTGCAAGTCACTCTGGTTTCAAAATCTTCACGGCTCCCTCTGCTCACCCTGCTGCTGGGGGGCTT
TTTTCAGGGGTTGTATTATAAAATATGCACTGGCTGTGGTTTTTCATAAGATGTTTTGTGGCTTTTTAAAGAAGTGTCTTACTCCCTCTT
CTCTCATTTTTTTCTGCCTTGAAAAGGGGTGGTATTTCTTTTGGGGTCAACAAATACACATATCAGTTTCACTCCTAACCTTGTAAGTTC
AGGACTCATTTTCTTGGCAGCAAGTGGCAGGGGCTCTTTAGTCACTGGAGTTAACAGTAAGTCTGAGTATATTCTGAATAATGTAATTAT
GCAATTAATTGATAATCATACCTAAAGCACATTGAACTTCTAAGAGACAGGTGCTACGTAAGCACACTGTCTTTCTGGATGGGGACTTGT
ATTTTAAATAACTTATCATTCCAGCTATGTTGGACTAGGGTCCAAAGCATTTTATAATATTTTTTTTTAATCTAGGAAAAAGACCCAAAC
AAATCTAACTTCTTGCTTTCTCACCTATTTGAATTTTCTCCTACCTAATTTGTTTGTGTCTTTATTATAGCTCAGTTTGACTTCTCAAAC
TTTTCAAGGGTTGGGGCAGCTGCACTTTTAGGTTGCCTATAGGAAATATTGCATATGGAGATTACAGTGTTTTTCTGACCTAGTTCAAGA
CCAGAACATGGGTCATAGGGTTTTTATTCAGCAAAATGAAAACGTATCTTCAGAACTTAACATATTACTGGATGTGATACAGATTTTGCT
TTCTGTGGAATTGAAAATTCACAAAAATTCACAGCTTAAATTTCCCATCAGTGACTGGAGGAATTTTTTTCAGGTGCTTCCTATATTACC
ATCCCTCATGCATATTAACTCTTTAGAATTTTAGGTTAAGTGATGTCTATAGAAGTAGCCTGGAAAACCATGAGTTTTGGAGTTCAGTGA
CCCCCTGCTTTCCTCTGCTCCTCCCTTCCCAAGGCATTGAAGCTGAATGTGCCAACTGGCAGTTAGAAGCGAAAGATGGCATTGGGAGAA
ATTTTAGAGAGCTTTCAAACTCTTTATTCTCATGTTCCACATGGTCTAATTTTAACATAAATAATATGCCTTCACACTGGATTGTAAAAG
GCATGTGATTTTTGAGATTTTATTTTGTGATGTATTGTCTTCTGCAGTATTAAAGGGAAAGAGATATTAATGTGCATTACCCTATCTTGT
TTTTGAAGCCAGGGTAGTTGTATGATTTTGTTACCAGCAGTGCTAACCTGAATGTGACCTGGTTACCTTGGAAATGCAGGAACTTATATG
AATGTACTATAAAATAAAATGCGGACTGATTCCCAGGACTGTGCAGAGTCGAGATGCAGCCTGGTACCAGCTGCTGATGGCACCACTCAG
CGAGGATCAGAGGACAGCACTGCAGGAGGTGTACACACTGGCAGAGCACCGACGGACGGTGGCAGAGGAGATTTCAAGTGATGAAGAGGA
GACAAATGTAACTGCTCAAGCAATGCAGTCAAATAATGGAAGAGGTGAAGATGAGGAGGAGGAAGATGATGACTGGGATGAAGAAGTATT
GGAAGAAACCGCGCTTGAGGGGTTCAGTACTCCACTTGACCTTGACAATAGTGTGGATGAATATCAGTTTTTTACACAAGCTCTGATAAG
CATCATGACCGGAAGATGTGTATAATAGGACTGAGTATCCTTTTGGAATTGCAAAATCGACCTCCTGCAGTAGATGCTGTGGTGGGACAG
ATTGTTCCCTCAATTCTTTTCCTTTTCCTTGGCCTAAAGCAGGTCTGTGCTACTAGACAACTGGTAAACCGGGAAGATCGTTCAAAAGCA
GAGAAAGCTGATATGGAAGAAAATGTGCATTCCACTCTTCGTTCAACTTGTTTTGGAGAGATTAACTCGAGGGGTCAAAACTAGTGAGCT
TCGTACTATGTGTCTTCAGGTTGCAATTGCTGCCTTGTACTACAACCCTGATTTGCTGCTACATACTTTAGAACGAATTCAGTTGCCTCA
CAACCCTGGACCTATCACTGTACAGTTTATAAATCAATGGATGAATGATACAGATTGTTTTCTTGGGTACTATGTGGAGATGCAGGAGAA
GATGCAGAGTGTCATGCAGCTAAACTTCTGGAAGTCATCATTCTTCAGTGCAAAGGAAGGGGAATTGATCAGACATGATGCCTCTCCTGC
ATAATTATGTGACAATAGATACAGATACCTTACTATCAAATGCAAAACATTTAGAAATTCTTTTTACAATGTGTAGGAAGAATTCTATGA
AGAAATTCTTTCCCTGGCATACAGTTTAACCTGCCACAGTATTTCCCCTCAAATGTGGCAGCTTCTAGGTATACTATATGAAGTGTTTCA
GCAGGATTGCTTTGAATACTTTACAGATTACCCAGCAGTTAGAGAATATCTGTCTACGGATCATTGATCTTGTTCTGCAGAAACATGTAA
TTGGCTGAGATATTTGGCAAAGTTCTTCAAAGTGATGAATATGAAGAAGTTGAAGACAAAACAGTAATGGCTATGGGAATTTTACATACC
ATTGATACTATCTTAACAGTTGTAGAAGATCATAAAGAGCTAAGGAATATATGAAGCCACATGTGAGGCCTATTATGCAGGAACTGTTGC
ACATTGTTAGAGAGACAGAAAATGATGATGTTACTAATGTCATCCAGAAGATGATATGTGAATACAGTCAAGAGGTAGCCTCAATTGCTG
TTGATATGACCCAACACTTGTCTTGCTGGGTACTTCATGCATTTAGTTCTTTGAAGTTCCATAATGAGCTCAATCTAAGAAATGCCGTTG
AATTAGCGAAGAAGAGCCTGATTGAAGATAAAGAGATGCCTGTCAAAGTTGAAGCTGCCCTTGCTCTTCAGTCTTTAATTTCTAACCAGA
TACAAGAAGAGTTTATTCAAGGACCAAATGGAGCTGTTTCTACAAAATCATGTATTTCCATTATTATTGTCTAACCTGGGATATCTTCGA
GCTAGAGTGTTGCCAAAAATGATGGCATTCTGTTATCAAATCCTGACAGACCCGAACTTTGACCCTAGGAAGAAAGATGGAGCCCTGCAT
GTGATTGGTTCCCTAGCTGAGATTTTACTGAAGATATTTTTGAAGATTATGCTTCTCCCACCACAGCAGCCCAGACTCTCTTATATACTG
CTGCAAAGAAAAGAAAAGAGAATATCTCTGAAGATGTGATTTTTTCTGTGATGTGTTATAAAGATGAGGATGAAGAGCTGTGGCAAGAAG

>In-frame_ENST00000253408_ENST00000256079_TCGA-DB-5279_GFAP_chr17_42991395_-_IPO8_chr12_30823919_length(amino acids)=212AA_start in transcript=66_stop in transcript=704
MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFL
EQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQRQRRRL

--------------------------------------------------------------
>In-frame_ENST00000253408_ENST00000544829_TCGA-DB-5279_GFAP_chr17_42991395_-_IPO8_chr12_30823919_length(transcript)=3070nt_BP=588nt
ATCGCCAGTCTAGCCCACTCCTTCATAAAGCCCTCGCATCCCAGGAGCGAGCAGAGCCAGAGCAGGATGGAGAGGAGACGCATCACCTCC
GCTGCTCGCCGCTCCTACGTCTCCTCAGGGGAGATGATGGTGGGGGGCCTGGCTCCTGGCCGCCGTCTGGGTCCTGGCACCCGCCTCTCC
CTGGCTCGAATGCCCCCTCCACTCCCGACCCGGGTGGATTTCTCCCTGGCTGGGGCACTCAATGCTGGCTTCAAGGAGACCCGGGCCAGT
GAGCGGGCAGAGATGATGGAGCTCAATGACCGCTTTGCCAGCTACATCGAGAAGGTTCGCTTCCTGGAACAGCAAAACAAGGCGCTGGCT
GCTGAGCTGAACCAGCTGCGGGCCAAGGAGCCCACCAAGCTGGCAGACGTCTACCAGGCTGAGCTGCGAGAGCTGCGGCTGCGGCTCGAT
CAACTCACCGCCAACAGCGCCCGGCTGGAGGTTGAGAGGGACAATCTGGCACAGGACCTGGCCACTGTGAGGCAGAAGCTCCAGGATGAA
ACCAACCTGAGGCTGGAAGCCGAGAACAACCTGGCTGCCTATAGACAGAGGCAAAGAAGAAGATTGAACAACAGGGAGGCTTCACCTTTG
AAAACAAAGGAGTCCTCTCCGCATTTAATTTTGGGACTGTGCCCAGCAACAACTGAAGGAAAGAACATCAGCTGACCAAATGTCATCGCT
GCATTTTATTTCACAAGAGGAGTGTGAGGGTCAAGGGGATGAAATGAGGGGCTGCTTTTAGGGCCCTCCTGCTGTGCCAGTTACCATCTG
GCATTAGGCAGCACTTTTATCTACTCTTTCCCCTTTGACCTTTGTCACCCTGAAATATATATTTTAAACAGCTACTGTAAGTATGAAATG
AAAGAAAAACAATCATTGGACGGAAAAGGACAACCCATATGTTCCAAAGGCTGAATGCCCAAGGTTGTTTTAGAGGATTGGATAGACTTG
CACGTCTCAGGTTTTTGCCATGCAGAATCAATGGATTTATGCGGATAACAGTGCCTTCTGTTGTACATGAATTATCAGAAAAAACTGTGC
AGAGTCGAGATGCAGCCTGGTACCAGCTGCTGATGGCACCACTCAGCGAGGATCAGAGGACAGCACTGCAGGAGGTGTACACACTGGCAG
AGCACCGACGGACGGTGGCAGAGGAGATTTCAAGTGATGAAGAGGAGACAAATGTAACTGCTCAAGCAATGCAGTCAAATAATGGAAGAG
GTGAAGATGAGGAGGAGGAAGATGATGACTGGGATGAAGAAGTATTGGAAGAAACCGCGCTTGAGGGGTTCAGTACTCCACTTGACCTTG
ACAATAGTGTGGATGAATATCAGTTTTTTACACAAGCTCTGATAAGCATCATGACCGGAAGATGTGTATAATAGGACTGAGTATCCTTTT
GGAATTGCAAAATCGACCTCCTGCAGTAGATGCTGTGGTGGGACAGATTGTTCCCTCAATTCTTTTCCTTTTCCTTGGCCTAAAGCAGGT
CTGTGCTACTAGACAACTGGTAAACCGGGAAGATCGTTCAAAAGCAGAGAAAGCTGATATGGAAGAAAATGTGCATTCCACTCTTCGTTC
AACTTGTTTTGGAGAGATTAACTCGAGGGGTCAAAACTAGTGAGCTTCGTACTATGTGTCTTCAGGTTGCAATTGCTGCCTTGTACTACA
ACCCTGATTTGCTGCTACATACTTTAGAACGAATTCAGTTGCCTCACAACCCTGGACCTATCACTGTACAGTTTATAAATCAATGGATGA
ATGATACAGATTGTTTTCTTGGGTACTATGTGGAGATGCAGGAGAAGATGCAGAGTGTCATGCAGCTAAACTTCTGGAAGTCATCATTCT
TCAGTGCAAAGGAAGGGGAATTGATCAGACATGATGCCTCTCCTGCATAATTATGTGACAATAGATACAGATACCTTACTATCAAATGCA
AAACATTTAGAAATTCTTTTTACAATGTGTAGGAAGAATTCTATGAAGAAATTCTTTCCCTGGCATACAGTTTAACCTGCCACAGTATTT
CCCCTCAAATGTGGCAGCTTCTAGGTATACTATATGAAGTGTTTCAGCAGGATTGCTTTGAATACTTTACAGATTACCCAGCAGTTAGAG
AATATCTGTCTACGGATCATTGATCTTGTTCTGCAGAAACATGTAATTGGCTGAGATATTTGGCAAAGTTCTTCAAAGTGATGAATATGA
AGAAGTTGAAGACAAAACAGTAATGGCTATGGGAATTTTACATACCATTGATACTATCTTAACAGTTGTAGAAGATCATAAAGAGCTAAG
GAATATATGAAGCCACATGTGAGGCCTATTATGCAGGAACTGTTGCACATTGTTAGAGAGACAGAAAATGATGATGTTACTAATGTCATC
CAGAAGATGATATGTGAATACAGTCAAGAGGTAGCCTCAATTGCTGTTGATATGACCCAACACTTGTCTTGCTGGGTACTTCATGCATTT
AGTTCTTTGAAGTTCCATAATGAGCTCAATCTAAGAAATGCCGTTGAATTAGCGAAGAAGAGCCTGATTGAAGATAAAGAGATGCCTGTC
AAAGTTGAAGCTGCCCTTGCTCTTCAGTCTTTAATTTCTAACCAGATACAAGAAGAGTTTATTCAAGGACCAAATGGAGCTGTTTCTACA
AAATCATGTATTTCCATTATTATTGTCTAACCTGGGATATCTTCGAGCTAGAGTGTTGCCAAAAATGATGGCATTCTGTTATCAAATCCT
GACAGACCCGAACTTTGACCCTAGGAAGAAAGATGGAGCCCTGCATGTGATTGGTTCCCTAGCTGAGATTTTACTGAAGATATTTTTGAA
GATTATGCTTCTCCCACCACAGCAGCCCAGACTCTCTTATATACTGCTGCAAAGAAAAGAAAAGAGAATATCTCTGAAGATGTGATTTTT
TCTGTGATGTGTTATAAAGATGAGGATGAAGAGCTGTGGCAAGAAGATCCATATGAGTATATAAGGATGAAATTTGAAGCAGATGAAGCC

>In-frame_ENST00000253408_ENST00000544829_TCGA-DB-5279_GFAP_chr17_42991395_-_IPO8_chr12_30823919_length(amino acids)=212AA_start in transcript=66_stop in transcript=704
MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFL
EQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQRQRRRL

--------------------------------------------------------------
>In-frame_ENST00000435360_ENST00000256079_TCGA-DB-5279_GFAP_chr17_42991395_-_IPO8_chr12_30823919_length(transcript)=4496nt_BP=530nt
AGAGCAGGATGGAGAGGAGACGCATCACCTCCGCTGCTCGCCGCTCCTACGTCTCCTCAGGGGAGATGATGGTGGGGGGCCTGGCTCCTG
GCCGCCGTCTGGGTCCTGGCACCCGCCTCTCCCTGGCTCGAATGCCCCCTCCACTCCCGACCCGGGTGGATTTCTCCCTGGCTGGGGCAC
TCAATGCTGGCTTCAAGGAGACCCGGGCCAGTGAGCGGGCAGAGATGATGGAGCTCAATGACCGCTTTGCCAGCTACATCGAGAAGGTTC
GCTTCCTGGAACAGCAAAACAAGGCGCTGGCTGCTGAGCTGAACCAGCTGCGGGCCAAGGAGCCCACCAAGCTGGCAGACGTCTACCAGG
CTGAGCTGCGAGAGCTGCGGCTGCGGCTCGATCAACTCACCGCCAACAGCGCCCGGCTGGAGGTTGAGAGGGACAATCTGGCACAGGACC
TGGCCACTGTGAGGCAGAAGCTCCAGGATGAAACCAACCTGAGGCTGGAAGCCGAGAACAACCTGGCTGCCTATAGACAGAGGCAAAGAA
GAAGATTGAACAACAGGGAGGCTTCACCTTTGAAAACAAAGGAGTCCTCTCCGCATTTAATTTTGGGACTGTGCCCAGCAACAACTGAAG
GAAAGAACATCAGCTGACCAAATGTCATCGCTGCATTTTATTTCACAAGAGGAGTGTGAGGGTCAAGGGGATGAAATGAGGGGCTGCTTT
TAGGGCCCTCCTGCTGTGCCAGTTACCATCTGGCATTAGGCAGCACTTTTATCTACTCTTTCCCCTTTGACCTTTGTCACCCTGAAATAT
ATATTTTAAACAGCTACTGTAAGTATGAAATGAAAGAAAAACAATCATTGGACGGAAAAGGACAACCCATATGTTCCAAAGGCTGAATGC
CCAAGGTTGTTTTAGAGGATTGGATAGACTTGCACGTCTCAGGTTTTTGCCATGCAGAATCAATGGATTTATGCGGATAACAGTGCCTTC
TGTTGTACATGAATTATCAGAAAAAAATTTTTGGAGTGCATTGCAATTTTTTTTAAAGCATAAAACATATTTCTAGATACAACATAAACC
TTGGTTATATGTCAACTATTCTGCATTTTACTCTGTGAATTTATTGTTAGGCAGTTACTGCAAGTCACTCTGGTTTCAAAATCTTCACGG
CTCCCTCTGCTCACCCTGCTGCTGGGGGGCTTTTTTCAGGGGTTGTATTATAAAATATGCACTGGCTGTGGTTTTTCATAAGATGTTTTG
TGGCTTTTTAAAGAAGTGTCTTACTCCCTCTTCTCTCATTTTTTTCTGCCTTGAAAAGGGGTGGTATTTCTTTTGGGGTCAACAAATACA
CATATCAGTTTCACTCCTAACCTTGTAAGTTCAGGACTCATTTTCTTGGCAGCAAGTGGCAGGGGCTCTTTAGTCACTGGAGTTAACAGT
AAGTCTGAGTATATTCTGAATAATGTAATTATGCAATTAATTGATAATCATACCTAAAGCACATTGAACTTCTAAGAGACAGGTGCTACG
TAAGCACACTGTCTTTCTGGATGGGGACTTGTATTTTAAATAACTTATCATTCCAGCTATGTTGGACTAGGGTCCAAAGCATTTTATAAT
ATTTTTTTTTAATCTAGGAAAAAGACCCAAACAAATCTAACTTCTTGCTTTCTCACCTATTTGAATTTTCTCCTACCTAATTTGTTTGTG
TCTTTATTATAGCTCAGTTTGACTTCTCAAACTTTTCAAGGGTTGGGGCAGCTGCACTTTTAGGTTGCCTATAGGAAATATTGCATATGG
AGATTACAGTGTTTTTCTGACCTAGTTCAAGACCAGAACATGGGTCATAGGGTTTTTATTCAGCAAAATGAAAACGTATCTTCAGAACTT
AACATATTACTGGATGTGATACAGATTTTGCTTTCTGTGGAATTGAAAATTCACAAAAATTCACAGCTTAAATTTCCCATCAGTGACTGG
AGGAATTTTTTTCAGGTGCTTCCTATATTACCATCCCTCATGCATATTAACTCTTTAGAATTTTAGGTTAAGTGATGTCTATAGAAGTAG
CCTGGAAAACCATGAGTTTTGGAGTTCAGTGACCCCCTGCTTTCCTCTGCTCCTCCCTTCCCAAGGCATTGAAGCTGAATGTGCCAACTG
GCAGTTAGAAGCGAAAGATGGCATTGGGAGAAATTTTAGAGAGCTTTCAAACTCTTTATTCTCATGTTCCACATGGTCTAATTTTAACAT
AAATAATATGCCTTCACACTGGATTGTAAAAGGCATGTGATTTTTGAGATTTTATTTTGTGATGTATTGTCTTCTGCAGTATTAAAGGGA
AAGAGATATTAATGTGCATTACCCTATCTTGTTTTTGAAGCCAGGGTAGTTGTATGATTTTGTTACCAGCAGTGCTAACCTGAATGTGAC
CTGGTTACCTTGGAAATGCAGGAACTTATATGAATGTACTATAAAATAAAATGCGGACTGATTCCCAGGACTGTGCAGAGTCGAGATGCA
GCCTGGTACCAGCTGCTGATGGCACCACTCAGCGAGGATCAGAGGACAGCACTGCAGGAGGTGTACACACTGGCAGAGCACCGACGGACG
GTGGCAGAGGAGATTTCAAGTGATGAAGAGGAGACAAATGTAACTGCTCAAGCAATGCAGTCAAATAATGGAAGAGGTGAAGATGAGGAG
GAGGAAGATGATGACTGGGATGAAGAAGTATTGGAAGAAACCGCGCTTGAGGGGTTCAGTACTCCACTTGACCTTGACAATAGTGTGGAT
GAATATCAGTTTTTTACACAAGCTCTGATAAGCATCATGACCGGAAGATGTGTATAATAGGACTGAGTATCCTTTTGGAATTGCAAAATC
GACCTCCTGCAGTAGATGCTGTGGTGGGACAGATTGTTCCCTCAATTCTTTTCCTTTTCCTTGGCCTAAAGCAGGTCTGTGCTACTAGAC
AACTGGTAAACCGGGAAGATCGTTCAAAAGCAGAGAAAGCTGATATGGAAGAAAATGTGCATTCCACTCTTCGTTCAACTTGTTTTGGAG
AGATTAACTCGAGGGGTCAAAACTAGTGAGCTTCGTACTATGTGTCTTCAGGTTGCAATTGCTGCCTTGTACTACAACCCTGATTTGCTG
CTACATACTTTAGAACGAATTCAGTTGCCTCACAACCCTGGACCTATCACTGTACAGTTTATAAATCAATGGATGAATGATACAGATTGT
TTTCTTGGGTACTATGTGGAGATGCAGGAGAAGATGCAGAGTGTCATGCAGCTAAACTTCTGGAAGTCATCATTCTTCAGTGCAAAGGAA
GGGGAATTGATCAGACATGATGCCTCTCCTGCATAATTATGTGACAATAGATACAGATACCTTACTATCAAATGCAAAACATTTAGAAAT
TCTTTTTACAATGTGTAGGAAGAATTCTATGAAGAAATTCTTTCCCTGGCATACAGTTTAACCTGCCACAGTATTTCCCCTCAAATGTGG
CAGCTTCTAGGTATACTATATGAAGTGTTTCAGCAGGATTGCTTTGAATACTTTACAGATTACCCAGCAGTTAGAGAATATCTGTCTACG
GATCATTGATCTTGTTCTGCAGAAACATGTAATTGGCTGAGATATTTGGCAAAGTTCTTCAAAGTGATGAATATGAAGAAGTTGAAGACA
AAACAGTAATGGCTATGGGAATTTTACATACCATTGATACTATCTTAACAGTTGTAGAAGATCATAAAGAGCTAAGGAATATATGAAGCC
ACATGTGAGGCCTATTATGCAGGAACTGTTGCACATTGTTAGAGAGACAGAAAATGATGATGTTACTAATGTCATCCAGAAGATGATATG
TGAATACAGTCAAGAGGTAGCCTCAATTGCTGTTGATATGACCCAACACTTGTCTTGCTGGGTACTTCATGCATTTAGTTCTTTGAAGTT
CCATAATGAGCTCAATCTAAGAAATGCCGTTGAATTAGCGAAGAAGAGCCTGATTGAAGATAAAGAGATGCCTGTCAAAGTTGAAGCTGC
CCTTGCTCTTCAGTCTTTAATTTCTAACCAGATACAAGAAGAGTTTATTCAAGGACCAAATGGAGCTGTTTCTACAAAATCATGTATTTC
CATTATTATTGTCTAACCTGGGATATCTTCGAGCTAGAGTGTTGCCAAAAATGATGGCATTCTGTTATCAAATCCTGACAGACCCGAACT
TTGACCCTAGGAAGAAAGATGGAGCCCTGCATGTGATTGGTTCCCTAGCTGAGATTTTACTGAAGATATTTTTGAAGATTATGCTTCTCC
CACCACAGCAGCCCAGACTCTCTTATATACTGCTGCAAAGAAAAGAAAAGAGAATATCTCTGAAGATGTGATTTTTTCTGTGATGTGTTA

>In-frame_ENST00000435360_ENST00000256079_TCGA-DB-5279_GFAP_chr17_42991395_-_IPO8_chr12_30823919_length(amino acids)=212AA_start in transcript=8_stop in transcript=646
MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFL
EQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQRQRRRL

--------------------------------------------------------------
>In-frame_ENST00000435360_ENST00000544829_TCGA-DB-5279_GFAP_chr17_42991395_-_IPO8_chr12_30823919_length(transcript)=3012nt_BP=530nt
AGAGCAGGATGGAGAGGAGACGCATCACCTCCGCTGCTCGCCGCTCCTACGTCTCCTCAGGGGAGATGATGGTGGGGGGCCTGGCTCCTG
GCCGCCGTCTGGGTCCTGGCACCCGCCTCTCCCTGGCTCGAATGCCCCCTCCACTCCCGACCCGGGTGGATTTCTCCCTGGCTGGGGCAC
TCAATGCTGGCTTCAAGGAGACCCGGGCCAGTGAGCGGGCAGAGATGATGGAGCTCAATGACCGCTTTGCCAGCTACATCGAGAAGGTTC
GCTTCCTGGAACAGCAAAACAAGGCGCTGGCTGCTGAGCTGAACCAGCTGCGGGCCAAGGAGCCCACCAAGCTGGCAGACGTCTACCAGG
CTGAGCTGCGAGAGCTGCGGCTGCGGCTCGATCAACTCACCGCCAACAGCGCCCGGCTGGAGGTTGAGAGGGACAATCTGGCACAGGACC
TGGCCACTGTGAGGCAGAAGCTCCAGGATGAAACCAACCTGAGGCTGGAAGCCGAGAACAACCTGGCTGCCTATAGACAGAGGCAAAGAA
GAAGATTGAACAACAGGGAGGCTTCACCTTTGAAAACAAAGGAGTCCTCTCCGCATTTAATTTTGGGACTGTGCCCAGCAACAACTGAAG
GAAAGAACATCAGCTGACCAAATGTCATCGCTGCATTTTATTTCACAAGAGGAGTGTGAGGGTCAAGGGGATGAAATGAGGGGCTGCTTT
TAGGGCCCTCCTGCTGTGCCAGTTACCATCTGGCATTAGGCAGCACTTTTATCTACTCTTTCCCCTTTGACCTTTGTCACCCTGAAATAT
ATATTTTAAACAGCTACTGTAAGTATGAAATGAAAGAAAAACAATCATTGGACGGAAAAGGACAACCCATATGTTCCAAAGGCTGAATGC
CCAAGGTTGTTTTAGAGGATTGGATAGACTTGCACGTCTCAGGTTTTTGCCATGCAGAATCAATGGATTTATGCGGATAACAGTGCCTTC
TGTTGTACATGAATTATCAGAAAAAACTGTGCAGAGTCGAGATGCAGCCTGGTACCAGCTGCTGATGGCACCACTCAGCGAGGATCAGAG
GACAGCACTGCAGGAGGTGTACACACTGGCAGAGCACCGACGGACGGTGGCAGAGGAGATTTCAAGTGATGAAGAGGAGACAAATGTAAC
TGCTCAAGCAATGCAGTCAAATAATGGAAGAGGTGAAGATGAGGAGGAGGAAGATGATGACTGGGATGAAGAAGTATTGGAAGAAACCGC
GCTTGAGGGGTTCAGTACTCCACTTGACCTTGACAATAGTGTGGATGAATATCAGTTTTTTACACAAGCTCTGATAAGCATCATGACCGG
AAGATGTGTATAATAGGACTGAGTATCCTTTTGGAATTGCAAAATCGACCTCCTGCAGTAGATGCTGTGGTGGGACAGATTGTTCCCTCA
ATTCTTTTCCTTTTCCTTGGCCTAAAGCAGGTCTGTGCTACTAGACAACTGGTAAACCGGGAAGATCGTTCAAAAGCAGAGAAAGCTGAT
ATGGAAGAAAATGTGCATTCCACTCTTCGTTCAACTTGTTTTGGAGAGATTAACTCGAGGGGTCAAAACTAGTGAGCTTCGTACTATGTG
TCTTCAGGTTGCAATTGCTGCCTTGTACTACAACCCTGATTTGCTGCTACATACTTTAGAACGAATTCAGTTGCCTCACAACCCTGGACC
TATCACTGTACAGTTTATAAATCAATGGATGAATGATACAGATTGTTTTCTTGGGTACTATGTGGAGATGCAGGAGAAGATGCAGAGTGT
CATGCAGCTAAACTTCTGGAAGTCATCATTCTTCAGTGCAAAGGAAGGGGAATTGATCAGACATGATGCCTCTCCTGCATAATTATGTGA
CAATAGATACAGATACCTTACTATCAAATGCAAAACATTTAGAAATTCTTTTTACAATGTGTAGGAAGAATTCTATGAAGAAATTCTTTC
CCTGGCATACAGTTTAACCTGCCACAGTATTTCCCCTCAAATGTGGCAGCTTCTAGGTATACTATATGAAGTGTTTCAGCAGGATTGCTT
TGAATACTTTACAGATTACCCAGCAGTTAGAGAATATCTGTCTACGGATCATTGATCTTGTTCTGCAGAAACATGTAATTGGCTGAGATA
TTTGGCAAAGTTCTTCAAAGTGATGAATATGAAGAAGTTGAAGACAAAACAGTAATGGCTATGGGAATTTTACATACCATTGATACTATC
TTAACAGTTGTAGAAGATCATAAAGAGCTAAGGAATATATGAAGCCACATGTGAGGCCTATTATGCAGGAACTGTTGCACATTGTTAGAG
AGACAGAAAATGATGATGTTACTAATGTCATCCAGAAGATGATATGTGAATACAGTCAAGAGGTAGCCTCAATTGCTGTTGATATGACCC
AACACTTGTCTTGCTGGGTACTTCATGCATTTAGTTCTTTGAAGTTCCATAATGAGCTCAATCTAAGAAATGCCGTTGAATTAGCGAAGA
AGAGCCTGATTGAAGATAAAGAGATGCCTGTCAAAGTTGAAGCTGCCCTTGCTCTTCAGTCTTTAATTTCTAACCAGATACAAGAAGAGT
TTATTCAAGGACCAAATGGAGCTGTTTCTACAAAATCATGTATTTCCATTATTATTGTCTAACCTGGGATATCTTCGAGCTAGAGTGTTG
CCAAAAATGATGGCATTCTGTTATCAAATCCTGACAGACCCGAACTTTGACCCTAGGAAGAAAGATGGAGCCCTGCATGTGATTGGTTCC
CTAGCTGAGATTTTACTGAAGATATTTTTGAAGATTATGCTTCTCCCACCACAGCAGCCCAGACTCTCTTATATACTGCTGCAAAGAAAA
GAAAAGAGAATATCTCTGAAGATGTGATTTTTTCTGTGATGTGTTATAAAGATGAGGATGAAGAGCTGTGGCAAGAAGATCCATATGAGT

>In-frame_ENST00000435360_ENST00000544829_TCGA-DB-5279_GFAP_chr17_42991395_-_IPO8_chr12_30823919_length(amino acids)=212AA_start in transcript=8_stop in transcript=646
MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFL
EQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQRQRRRL

--------------------------------------------------------------
>In-frame_ENST00000586793_ENST00000256079_TCGA-DB-5279_GFAP_chr17_42991395_-_IPO8_chr12_30823919_length(transcript)=4496nt_BP=530nt
AGAGCAGGATGGAGAGGAGACGCATCACCTCCGCTGCTCGCCGCTCCTACGTCTCCTCAGGGGAGATGATGGTGGGGGGCCTGGCTCCTG
GCCGCCGTCTGGGTCCTGGCACCCGCCTCTCCCTGGCTCGAATGCCCCCTCCACTCCCGACCCGGGTGGATTTCTCCCTGGCTGGGGCAC
TCAATGCTGGCTTCAAGGAGACCCGGGCCAGTGAGCGGGCAGAGATGATGGAGCTCAATGACCGCTTTGCCAGCTACATCGAGAAGGTTC
GCTTCCTGGAACAGCAAAACAAGGCGCTGGCTGCTGAGCTGAACCAGCTGCGGGCCAAGGAGCCCACCAAGCTGGCAGACGTCTACCAGG
CTGAGCTGCGAGAGCTGCGGCTGCGGCTCGATCAACTCACCGCCAACAGCGCCCGGCTGGAGGTTGAGAGGGACAATCTGGCACAGGACC
TGGCCACTGTGAGGCAGAAGCTCCAGGATGAAACCAACCTGAGGCTGGAAGCCGAGAACAACCTGGCTGCCTATAGACAGAGGCAAAGAA
GAAGATTGAACAACAGGGAGGCTTCACCTTTGAAAACAAAGGAGTCCTCTCCGCATTTAATTTTGGGACTGTGCCCAGCAACAACTGAAG
GAAAGAACATCAGCTGACCAAATGTCATCGCTGCATTTTATTTCACAAGAGGAGTGTGAGGGTCAAGGGGATGAAATGAGGGGCTGCTTT
TAGGGCCCTCCTGCTGTGCCAGTTACCATCTGGCATTAGGCAGCACTTTTATCTACTCTTTCCCCTTTGACCTTTGTCACCCTGAAATAT
ATATTTTAAACAGCTACTGTAAGTATGAAATGAAAGAAAAACAATCATTGGACGGAAAAGGACAACCCATATGTTCCAAAGGCTGAATGC
CCAAGGTTGTTTTAGAGGATTGGATAGACTTGCACGTCTCAGGTTTTTGCCATGCAGAATCAATGGATTTATGCGGATAACAGTGCCTTC
TGTTGTACATGAATTATCAGAAAAAAATTTTTGGAGTGCATTGCAATTTTTTTTAAAGCATAAAACATATTTCTAGATACAACATAAACC
TTGGTTATATGTCAACTATTCTGCATTTTACTCTGTGAATTTATTGTTAGGCAGTTACTGCAAGTCACTCTGGTTTCAAAATCTTCACGG
CTCCCTCTGCTCACCCTGCTGCTGGGGGGCTTTTTTCAGGGGTTGTATTATAAAATATGCACTGGCTGTGGTTTTTCATAAGATGTTTTG
TGGCTTTTTAAAGAAGTGTCTTACTCCCTCTTCTCTCATTTTTTTCTGCCTTGAAAAGGGGTGGTATTTCTTTTGGGGTCAACAAATACA
CATATCAGTTTCACTCCTAACCTTGTAAGTTCAGGACTCATTTTCTTGGCAGCAAGTGGCAGGGGCTCTTTAGTCACTGGAGTTAACAGT
AAGTCTGAGTATATTCTGAATAATGTAATTATGCAATTAATTGATAATCATACCTAAAGCACATTGAACTTCTAAGAGACAGGTGCTACG
TAAGCACACTGTCTTTCTGGATGGGGACTTGTATTTTAAATAACTTATCATTCCAGCTATGTTGGACTAGGGTCCAAAGCATTTTATAAT
ATTTTTTTTTAATCTAGGAAAAAGACCCAAACAAATCTAACTTCTTGCTTTCTCACCTATTTGAATTTTCTCCTACCTAATTTGTTTGTG
TCTTTATTATAGCTCAGTTTGACTTCTCAAACTTTTCAAGGGTTGGGGCAGCTGCACTTTTAGGTTGCCTATAGGAAATATTGCATATGG
AGATTACAGTGTTTTTCTGACCTAGTTCAAGACCAGAACATGGGTCATAGGGTTTTTATTCAGCAAAATGAAAACGTATCTTCAGAACTT
AACATATTACTGGATGTGATACAGATTTTGCTTTCTGTGGAATTGAAAATTCACAAAAATTCACAGCTTAAATTTCCCATCAGTGACTGG
AGGAATTTTTTTCAGGTGCTTCCTATATTACCATCCCTCATGCATATTAACTCTTTAGAATTTTAGGTTAAGTGATGTCTATAGAAGTAG
CCTGGAAAACCATGAGTTTTGGAGTTCAGTGACCCCCTGCTTTCCTCTGCTCCTCCCTTCCCAAGGCATTGAAGCTGAATGTGCCAACTG
GCAGTTAGAAGCGAAAGATGGCATTGGGAGAAATTTTAGAGAGCTTTCAAACTCTTTATTCTCATGTTCCACATGGTCTAATTTTAACAT
AAATAATATGCCTTCACACTGGATTGTAAAAGGCATGTGATTTTTGAGATTTTATTTTGTGATGTATTGTCTTCTGCAGTATTAAAGGGA
AAGAGATATTAATGTGCATTACCCTATCTTGTTTTTGAAGCCAGGGTAGTTGTATGATTTTGTTACCAGCAGTGCTAACCTGAATGTGAC
CTGGTTACCTTGGAAATGCAGGAACTTATATGAATGTACTATAAAATAAAATGCGGACTGATTCCCAGGACTGTGCAGAGTCGAGATGCA
GCCTGGTACCAGCTGCTGATGGCACCACTCAGCGAGGATCAGAGGACAGCACTGCAGGAGGTGTACACACTGGCAGAGCACCGACGGACG
GTGGCAGAGGAGATTTCAAGTGATGAAGAGGAGACAAATGTAACTGCTCAAGCAATGCAGTCAAATAATGGAAGAGGTGAAGATGAGGAG
GAGGAAGATGATGACTGGGATGAAGAAGTATTGGAAGAAACCGCGCTTGAGGGGTTCAGTACTCCACTTGACCTTGACAATAGTGTGGAT
GAATATCAGTTTTTTACACAAGCTCTGATAAGCATCATGACCGGAAGATGTGTATAATAGGACTGAGTATCCTTTTGGAATTGCAAAATC
GACCTCCTGCAGTAGATGCTGTGGTGGGACAGATTGTTCCCTCAATTCTTTTCCTTTTCCTTGGCCTAAAGCAGGTCTGTGCTACTAGAC
AACTGGTAAACCGGGAAGATCGTTCAAAAGCAGAGAAAGCTGATATGGAAGAAAATGTGCATTCCACTCTTCGTTCAACTTGTTTTGGAG
AGATTAACTCGAGGGGTCAAAACTAGTGAGCTTCGTACTATGTGTCTTCAGGTTGCAATTGCTGCCTTGTACTACAACCCTGATTTGCTG
CTACATACTTTAGAACGAATTCAGTTGCCTCACAACCCTGGACCTATCACTGTACAGTTTATAAATCAATGGATGAATGATACAGATTGT
TTTCTTGGGTACTATGTGGAGATGCAGGAGAAGATGCAGAGTGTCATGCAGCTAAACTTCTGGAAGTCATCATTCTTCAGTGCAAAGGAA
GGGGAATTGATCAGACATGATGCCTCTCCTGCATAATTATGTGACAATAGATACAGATACCTTACTATCAAATGCAAAACATTTAGAAAT
TCTTTTTACAATGTGTAGGAAGAATTCTATGAAGAAATTCTTTCCCTGGCATACAGTTTAACCTGCCACAGTATTTCCCCTCAAATGTGG
CAGCTTCTAGGTATACTATATGAAGTGTTTCAGCAGGATTGCTTTGAATACTTTACAGATTACCCAGCAGTTAGAGAATATCTGTCTACG
GATCATTGATCTTGTTCTGCAGAAACATGTAATTGGCTGAGATATTTGGCAAAGTTCTTCAAAGTGATGAATATGAAGAAGTTGAAGACA
AAACAGTAATGGCTATGGGAATTTTACATACCATTGATACTATCTTAACAGTTGTAGAAGATCATAAAGAGCTAAGGAATATATGAAGCC
ACATGTGAGGCCTATTATGCAGGAACTGTTGCACATTGTTAGAGAGACAGAAAATGATGATGTTACTAATGTCATCCAGAAGATGATATG
TGAATACAGTCAAGAGGTAGCCTCAATTGCTGTTGATATGACCCAACACTTGTCTTGCTGGGTACTTCATGCATTTAGTTCTTTGAAGTT
CCATAATGAGCTCAATCTAAGAAATGCCGTTGAATTAGCGAAGAAGAGCCTGATTGAAGATAAAGAGATGCCTGTCAAAGTTGAAGCTGC
CCTTGCTCTTCAGTCTTTAATTTCTAACCAGATACAAGAAGAGTTTATTCAAGGACCAAATGGAGCTGTTTCTACAAAATCATGTATTTC
CATTATTATTGTCTAACCTGGGATATCTTCGAGCTAGAGTGTTGCCAAAAATGATGGCATTCTGTTATCAAATCCTGACAGACCCGAACT
TTGACCCTAGGAAGAAAGATGGAGCCCTGCATGTGATTGGTTCCCTAGCTGAGATTTTACTGAAGATATTTTTGAAGATTATGCTTCTCC
CACCACAGCAGCCCAGACTCTCTTATATACTGCTGCAAAGAAAAGAAAAGAGAATATCTCTGAAGATGTGATTTTTTCTGTGATGTGTTA

>In-frame_ENST00000586793_ENST00000256079_TCGA-DB-5279_GFAP_chr17_42991395_-_IPO8_chr12_30823919_length(amino acids)=212AA_start in transcript=8_stop in transcript=646
MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFL
EQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQRQRRRL

--------------------------------------------------------------
>In-frame_ENST00000586793_ENST00000544829_TCGA-DB-5279_GFAP_chr17_42991395_-_IPO8_chr12_30823919_length(transcript)=3012nt_BP=530nt
AGAGCAGGATGGAGAGGAGACGCATCACCTCCGCTGCTCGCCGCTCCTACGTCTCCTCAGGGGAGATGATGGTGGGGGGCCTGGCTCCTG
GCCGCCGTCTGGGTCCTGGCACCCGCCTCTCCCTGGCTCGAATGCCCCCTCCACTCCCGACCCGGGTGGATTTCTCCCTGGCTGGGGCAC
TCAATGCTGGCTTCAAGGAGACCCGGGCCAGTGAGCGGGCAGAGATGATGGAGCTCAATGACCGCTTTGCCAGCTACATCGAGAAGGTTC
GCTTCCTGGAACAGCAAAACAAGGCGCTGGCTGCTGAGCTGAACCAGCTGCGGGCCAAGGAGCCCACCAAGCTGGCAGACGTCTACCAGG
CTGAGCTGCGAGAGCTGCGGCTGCGGCTCGATCAACTCACCGCCAACAGCGCCCGGCTGGAGGTTGAGAGGGACAATCTGGCACAGGACC
TGGCCACTGTGAGGCAGAAGCTCCAGGATGAAACCAACCTGAGGCTGGAAGCCGAGAACAACCTGGCTGCCTATAGACAGAGGCAAAGAA
GAAGATTGAACAACAGGGAGGCTTCACCTTTGAAAACAAAGGAGTCCTCTCCGCATTTAATTTTGGGACTGTGCCCAGCAACAACTGAAG
GAAAGAACATCAGCTGACCAAATGTCATCGCTGCATTTTATTTCACAAGAGGAGTGTGAGGGTCAAGGGGATGAAATGAGGGGCTGCTTT
TAGGGCCCTCCTGCTGTGCCAGTTACCATCTGGCATTAGGCAGCACTTTTATCTACTCTTTCCCCTTTGACCTTTGTCACCCTGAAATAT
ATATTTTAAACAGCTACTGTAAGTATGAAATGAAAGAAAAACAATCATTGGACGGAAAAGGACAACCCATATGTTCCAAAGGCTGAATGC
CCAAGGTTGTTTTAGAGGATTGGATAGACTTGCACGTCTCAGGTTTTTGCCATGCAGAATCAATGGATTTATGCGGATAACAGTGCCTTC
TGTTGTACATGAATTATCAGAAAAAACTGTGCAGAGTCGAGATGCAGCCTGGTACCAGCTGCTGATGGCACCACTCAGCGAGGATCAGAG
GACAGCACTGCAGGAGGTGTACACACTGGCAGAGCACCGACGGACGGTGGCAGAGGAGATTTCAAGTGATGAAGAGGAGACAAATGTAAC
TGCTCAAGCAATGCAGTCAAATAATGGAAGAGGTGAAGATGAGGAGGAGGAAGATGATGACTGGGATGAAGAAGTATTGGAAGAAACCGC
GCTTGAGGGGTTCAGTACTCCACTTGACCTTGACAATAGTGTGGATGAATATCAGTTTTTTACACAAGCTCTGATAAGCATCATGACCGG
AAGATGTGTATAATAGGACTGAGTATCCTTTTGGAATTGCAAAATCGACCTCCTGCAGTAGATGCTGTGGTGGGACAGATTGTTCCCTCA
ATTCTTTTCCTTTTCCTTGGCCTAAAGCAGGTCTGTGCTACTAGACAACTGGTAAACCGGGAAGATCGTTCAAAAGCAGAGAAAGCTGAT
ATGGAAGAAAATGTGCATTCCACTCTTCGTTCAACTTGTTTTGGAGAGATTAACTCGAGGGGTCAAAACTAGTGAGCTTCGTACTATGTG
TCTTCAGGTTGCAATTGCTGCCTTGTACTACAACCCTGATTTGCTGCTACATACTTTAGAACGAATTCAGTTGCCTCACAACCCTGGACC
TATCACTGTACAGTTTATAAATCAATGGATGAATGATACAGATTGTTTTCTTGGGTACTATGTGGAGATGCAGGAGAAGATGCAGAGTGT
CATGCAGCTAAACTTCTGGAAGTCATCATTCTTCAGTGCAAAGGAAGGGGAATTGATCAGACATGATGCCTCTCCTGCATAATTATGTGA
CAATAGATACAGATACCTTACTATCAAATGCAAAACATTTAGAAATTCTTTTTACAATGTGTAGGAAGAATTCTATGAAGAAATTCTTTC
CCTGGCATACAGTTTAACCTGCCACAGTATTTCCCCTCAAATGTGGCAGCTTCTAGGTATACTATATGAAGTGTTTCAGCAGGATTGCTT
TGAATACTTTACAGATTACCCAGCAGTTAGAGAATATCTGTCTACGGATCATTGATCTTGTTCTGCAGAAACATGTAATTGGCTGAGATA
TTTGGCAAAGTTCTTCAAAGTGATGAATATGAAGAAGTTGAAGACAAAACAGTAATGGCTATGGGAATTTTACATACCATTGATACTATC
TTAACAGTTGTAGAAGATCATAAAGAGCTAAGGAATATATGAAGCCACATGTGAGGCCTATTATGCAGGAACTGTTGCACATTGTTAGAG
AGACAGAAAATGATGATGTTACTAATGTCATCCAGAAGATGATATGTGAATACAGTCAAGAGGTAGCCTCAATTGCTGTTGATATGACCC
AACACTTGTCTTGCTGGGTACTTCATGCATTTAGTTCTTTGAAGTTCCATAATGAGCTCAATCTAAGAAATGCCGTTGAATTAGCGAAGA
AGAGCCTGATTGAAGATAAAGAGATGCCTGTCAAAGTTGAAGCTGCCCTTGCTCTTCAGTCTTTAATTTCTAACCAGATACAAGAAGAGT
TTATTCAAGGACCAAATGGAGCTGTTTCTACAAAATCATGTATTTCCATTATTATTGTCTAACCTGGGATATCTTCGAGCTAGAGTGTTG
CCAAAAATGATGGCATTCTGTTATCAAATCCTGACAGACCCGAACTTTGACCCTAGGAAGAAAGATGGAGCCCTGCATGTGATTGGTTCC
CTAGCTGAGATTTTACTGAAGATATTTTTGAAGATTATGCTTCTCCCACCACAGCAGCCCAGACTCTCTTATATACTGCTGCAAAGAAAA
GAAAAGAGAATATCTCTGAAGATGTGATTTTTTCTGTGATGTGTTATAAAGATGAGGATGAAGAGCTGTGGCAAGAAGATCCATATGAGT

>In-frame_ENST00000586793_ENST00000544829_TCGA-DB-5279_GFAP_chr17_42991395_-_IPO8_chr12_30823919_length(amino acids)=212AA_start in transcript=8_stop in transcript=646
MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFL
EQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQRQRRRL

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Fusion Gene PPI Analysis for GFAP-IPO8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GFAP-IPO8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GFAP-IPO8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGFAPC0270726Alexander Disease30CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneGFAPC0011570Mental Depression3PSYGENET
HgeneGFAPC0011581Depressive disorder3PSYGENET
HgeneGFAPC0027765nervous system disorder3CTD_human
HgeneGFAPC0005586Bipolar Disorder2PSYGENET
HgeneGFAPC0036341Schizophrenia2PSYGENET
HgeneGFAPC0041696Unipolar Depression2PSYGENET
HgeneGFAPC1269683Major Depressive Disorder2PSYGENET
HgeneGFAPC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneGFAPC0002736Amyotrophic Lateral Sclerosis1CTD_human
HgeneGFAPC0014544Epilepsy1CTD_human
HgeneGFAPC0017639Gliosis1CTD_human
HgeneGFAPC0020429Hyperalgesia1CTD_human
HgeneGFAPC0027873Neuromyelitis Optica1CTD_human
HgeneGFAPC0030567Parkinson Disease1CTD_human
HgeneGFAPC0036572Seizures1GENOMICS_ENGLAND
HgeneGFAPC0037917Spina Bifida Cystica1CTD_human
HgeneGFAPC0040997Trigeminal Neuralgia1CTD_human
HgeneGFAPC0086237Epilepsy, Cryptogenic1CTD_human
HgeneGFAPC0236018Aura1CTD_human
HgeneGFAPC0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
HgeneGFAPC0393786Trigeminal Neuralgia, Idiopathic1CTD_human
HgeneGFAPC0393787Secondary Trigeminal Neuralgia1CTD_human
HgeneGFAPC0458247Allodynia1CTD_human
HgeneGFAPC0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
HgeneGFAPC0751111Awakening Epilepsy1CTD_human
HgeneGFAPC0751211Hyperalgesia, Primary1CTD_human
HgeneGFAPC0751212Hyperalgesia, Secondary1CTD_human
HgeneGFAPC0751213Tactile Allodynia1CTD_human
HgeneGFAPC0751214Hyperalgesia, Thermal1CTD_human
HgeneGFAPC0752347Lewy Body Disease1CTD_human
HgeneGFAPC0917813Spina Bifida, Open1CTD_human
HgeneGFAPC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
HgeneGFAPC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
HgeneGFAPC2931673Ceroid lipofuscinosis, neuronal 1, infantile1CTD_human
HgeneGFAPC2936719Mechanical Allodynia1CTD_human
HgeneGFAPC3887640Astrocytosis1CTD_human
HgeneGFAPC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human
HgeneGFAPC4721453Peripheral Nervous System Diseases1CTD_human