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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABCA7-ABCA7 (FusionGDB2 ID:329)

Fusion Gene Summary for ABCA7-ABCA7

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCA7-ABCA7
Fusion gene ID: 329
HgeneTgene
Gene symbol

ABCA7

ABCA7

Gene ID

10347

10347

Gene nameATP binding cassette subfamily A member 7ATP binding cassette subfamily A member 7
SynonymsABCA-SSN|ABCX|AD9ABCA-SSN|ABCX|AD9
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionphospholipid-transporting ATPase ABCA7ATP-binding cassette sub-family A member 7ATP-binding cassette, sub-family A (ABC1), member 7autoantigen SS-Nmacrophage ABC transporterphospholipid-transporting ATPase ABCA7ATP-binding cassette sub-family A member 7ATP-binding cassette, sub-family A (ABC1), member 7autoantigen SS-Nmacrophage ABC transporter
Modification date2020032020200320
UniProtAcc.

Q8IZY2

Ensembl transtripts involved in fusion geneENST00000263094, ENST00000433129, 
ENST00000435683, ENST00000533574, 
ENST00000263094, ENST00000433129, 
ENST00000435683, ENST00000533574, 
Fusion gene scores* DoF score5 X 5 X 3=755 X 4 X 4=80
# samples 55
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABCA7 [Title/Abstract] AND ABCA7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCA7(1058747)-ABCA7(1058915), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCA7

GO:0033344

cholesterol efflux

14570867

HgeneABCA7

GO:0033700

phospholipid efflux

14570867

HgeneABCA7

GO:0034380

high-density lipoprotein particle assembly

14570867

HgeneABCA7

GO:0038027

apolipoprotein A-I-mediated signaling pathway

14570867

HgeneABCA7

GO:0045332

phospholipid translocation

24097981

TgeneABCA7

GO:0033344

cholesterol efflux

14570867

TgeneABCA7

GO:0033700

phospholipid efflux

14570867

TgeneABCA7

GO:0034380

high-density lipoprotein particle assembly

14570867

TgeneABCA7

GO:0038027

apolipoprotein A-I-mediated signaling pathway

14570867

TgeneABCA7

GO:0045332

phospholipid translocation

24097981


check buttonFusion gene breakpoints across ABCA7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ABCA7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI012955ABCA7chr19

1058747

+ABCA7chr19

1058915

-


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Fusion Gene ORF analysis for ABCA7-ABCA7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000263094ENST00000263094ABCA7chr19

1058747

+ABCA7chr19

1058915

-
In-frameENST00000263094ENST00000433129ABCA7chr19

1058747

+ABCA7chr19

1058915

-
In-frameENST00000263094ENST00000435683ABCA7chr19

1058747

+ABCA7chr19

1058915

-
5CDS-intronENST00000263094ENST00000533574ABCA7chr19

1058747

+ABCA7chr19

1058915

-
In-frameENST00000433129ENST00000263094ABCA7chr19

1058747

+ABCA7chr19

1058915

-
In-frameENST00000433129ENST00000433129ABCA7chr19

1058747

+ABCA7chr19

1058915

-
In-frameENST00000433129ENST00000435683ABCA7chr19

1058747

+ABCA7chr19

1058915

-
5CDS-intronENST00000433129ENST00000533574ABCA7chr19

1058747

+ABCA7chr19

1058915

-
In-frameENST00000435683ENST00000263094ABCA7chr19

1058747

+ABCA7chr19

1058915

-
In-frameENST00000435683ENST00000433129ABCA7chr19

1058747

+ABCA7chr19

1058915

-
In-frameENST00000435683ENST00000435683ABCA7chr19

1058747

+ABCA7chr19

1058915

-
5CDS-intronENST00000435683ENST00000533574ABCA7chr19

1058747

+ABCA7chr19

1058915

-
intron-3CDSENST00000533574ENST00000263094ABCA7chr19

1058747

+ABCA7chr19

1058915

-
intron-3CDSENST00000533574ENST00000433129ABCA7chr19

1058747

+ABCA7chr19

1058915

-
intron-3CDSENST00000533574ENST00000435683ABCA7chr19

1058747

+ABCA7chr19

1058915

-
intron-intronENST00000533574ENST00000533574ABCA7chr19

1058747

+ABCA7chr19

1058915

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ABCA7-ABCA7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ABCA7-ABCA7


check button Go to

FGviewer for the breakpoints of chr19:1058747-chr19:1058915

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ABCA7

Q8IZY2

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:14592415, PubMed:12917409, PubMed:12925201, PubMed:14570867). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791). {ECO:0000250|UniProtKB:Q91V24, ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:12925201, ECO:0000269|PubMed:14570867, ECO:0000269|PubMed:14592415, ECO:0000269|PubMed:24097981, ECO:0000269|PubMed:26260791}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+3847807_10381759.66666666666672147.0DomainABC transporter 1
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+3746807_10381759.66666666666672147.0DomainABC transporter 1
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+3241807_10381621.66666666666672009.0DomainABC transporter 1
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+3847841_8481759.66666666666672147.0Nucleotide bindingATP 1
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+3746841_8481759.66666666666672147.0Nucleotide bindingATP 1
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+3241841_8481621.66666666666672009.0Nucleotide bindingATP 1
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+38471264_15371759.66666666666672147.0Topological domainExtracellular
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+384743_5491759.66666666666672147.0Topological domainExtracellular
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+37461264_15371759.66666666666672147.0Topological domainExtracellular
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+374643_5491759.66666666666672147.0Topological domainExtracellular
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+32411264_15371621.66666666666672009.0Topological domainExtracellular
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+324143_5491621.66666666666672009.0Topological domainExtracellular
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+38471243_12631759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+38471538_15581759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+38471584_16041759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+38471621_16411759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+38471649_16691759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+38471683_17031759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+38471729_17491759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+384722_421759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+3847550_5701759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+3847593_6131759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+3847626_6461759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+3847655_6751759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+3847687_7071759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+3847727_7471759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+3847849_8691759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+37461243_12631759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+37461538_15581759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+37461584_16041759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+37461621_16411759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+37461649_16691759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+37461683_17031759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+37461729_17491759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+374622_421759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+3746550_5701759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+3746593_6131759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+3746626_6461759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+3746655_6751759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+3746687_7071759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+3746727_7471759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+3746849_8691759.66666666666672147.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+32411243_12631621.66666666666672009.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+32411538_15581621.66666666666672009.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+32411584_16041621.66666666666672009.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+324122_421621.66666666666672009.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+3241550_5701621.66666666666672009.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+3241593_6131621.66666666666672009.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+3241626_6461621.66666666666672009.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+3241655_6751621.66666666666672009.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+3241687_7071621.66666666666672009.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+3241727_7471621.66666666666672009.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+3241849_8691621.66666666666672009.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000002630940471793_202502147.0DomainABC transporter 2
TgeneABCA7chr19:1058747chr19:1058915ENST00000263094047807_103802147.0DomainABC transporter 1
TgeneABCA7chr19:1058747chr19:1058915ENST000004331290461793_20250.02147.0DomainABC transporter 2
TgeneABCA7chr19:1058747chr19:1058915ENST00000433129046807_10380.02147.0DomainABC transporter 1
TgeneABCA7chr19:1058747chr19:1058915ENST000004356830411793_20250.02009.0DomainABC transporter 2
TgeneABCA7chr19:1058747chr19:1058915ENST00000435683041807_10380.02009.0DomainABC transporter 1
TgeneABCA7chr19:1058747chr19:1058915ENST000002630940471827_183402147.0Nucleotide bindingATP 2
TgeneABCA7chr19:1058747chr19:1058915ENST00000263094047841_84802147.0Nucleotide bindingATP 1
TgeneABCA7chr19:1058747chr19:1058915ENST000004331290461827_18340.02147.0Nucleotide bindingATP 2
TgeneABCA7chr19:1058747chr19:1058915ENST00000433129046841_8480.02147.0Nucleotide bindingATP 1
TgeneABCA7chr19:1058747chr19:1058915ENST000004356830411827_18340.02009.0Nucleotide bindingATP 2
TgeneABCA7chr19:1058747chr19:1058915ENST00000435683041841_8480.02009.0Nucleotide bindingATP 1
TgeneABCA7chr19:1058747chr19:1058915ENST000002630940471264_153702147.0Topological domainExtracellular
TgeneABCA7chr19:1058747chr19:1058915ENST0000026309404743_54902147.0Topological domainExtracellular
TgeneABCA7chr19:1058747chr19:1058915ENST000004331290461264_15370.02147.0Topological domainExtracellular
TgeneABCA7chr19:1058747chr19:1058915ENST0000043312904643_5490.02147.0Topological domainExtracellular
TgeneABCA7chr19:1058747chr19:1058915ENST000004356830411264_15370.02009.0Topological domainExtracellular
TgeneABCA7chr19:1058747chr19:1058915ENST0000043568304143_5490.02009.0Topological domainExtracellular
TgeneABCA7chr19:1058747chr19:1058915ENST000002630940471243_126302147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000002630940471538_155802147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000002630940471584_160402147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000002630940471621_164102147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000002630940471649_166902147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000002630940471683_170302147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000002630940471729_174902147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST0000026309404722_4202147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000263094047550_57002147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000263094047593_61302147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000263094047626_64602147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000263094047655_67502147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000263094047687_70702147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000263094047727_74702147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000263094047849_86902147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000004331290461243_12630.02147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000004331290461538_15580.02147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000004331290461584_16040.02147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000004331290461621_16410.02147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000004331290461649_16690.02147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000004331290461683_17030.02147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000004331290461729_17490.02147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST0000043312904622_420.02147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000433129046550_5700.02147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000433129046593_6130.02147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000433129046626_6460.02147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000433129046655_6750.02147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000433129046687_7070.02147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000433129046727_7470.02147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000433129046849_8690.02147.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000004356830411243_12630.02009.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000004356830411538_15580.02009.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000004356830411584_16040.02009.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000004356830411621_16410.02009.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000004356830411649_16690.02009.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000004356830411683_17030.02009.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST000004356830411729_17490.02009.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST0000043568304122_420.02009.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000435683041550_5700.02009.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000435683041593_6130.02009.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000435683041626_6460.02009.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000435683041655_6750.02009.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000435683041687_7070.02009.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000435683041727_7470.02009.0TransmembraneHelical
TgeneABCA7chr19:1058747chr19:1058915ENST00000435683041849_8690.02009.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+38471793_20251759.66666666666672147.0DomainABC transporter 2
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+37461793_20251759.66666666666672147.0DomainABC transporter 2
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+32411793_20251621.66666666666672009.0DomainABC transporter 2
HgeneABCA7chr19:1058747chr19:1058915ENST00000263094+38471827_18341759.66666666666672147.0Nucleotide bindingATP 2
HgeneABCA7chr19:1058747chr19:1058915ENST00000433129+37461827_18341759.66666666666672147.0Nucleotide bindingATP 2
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+32411827_18341621.66666666666672009.0Nucleotide bindingATP 2
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+32411621_16411621.66666666666672009.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+32411649_16691621.66666666666672009.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+32411683_17031621.66666666666672009.0TransmembraneHelical
HgeneABCA7chr19:1058747chr19:1058915ENST00000435683+32411729_17491621.66666666666672009.0TransmembraneHelical


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Fusion Gene Sequence for ABCA7-ABCA7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ABCA7-ABCA7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABCA7-ABCA7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABCA7-ABCA7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCA7C0276496Familial Alzheimer Disease (FAD)3CTD_human;ORPHANET
HgeneABCA7C4282179ALZHEIMER DISEASE 9, SUSCEPTIBILITY TO3UNIPROT
HgeneABCA7C0002395Alzheimer's Disease2CTD_human
HgeneABCA7C0011265Presenile dementia2CTD_human
HgeneABCA7C0494463Alzheimer Disease, Late Onset2CTD_human
HgeneABCA7C0546126Acute Confusional Senile Dementia2CTD_human
HgeneABCA7C0750900Alzheimer's Disease, Focal Onset2CTD_human
HgeneABCA7C0750901Alzheimer Disease, Early Onset2CTD_human
HgeneABCA7C0235874Disease Exacerbation1CTD_human
TgeneABCA7C0276496Familial Alzheimer Disease (FAD)3CTD_human;ORPHANET
TgeneABCA7C4282179ALZHEIMER DISEASE 9, SUSCEPTIBILITY TO3UNIPROT
TgeneABCA7C0002395Alzheimer's Disease2CTD_human
TgeneABCA7C0011265Presenile dementia2CTD_human
TgeneABCA7C0494463Alzheimer Disease, Late Onset2CTD_human
TgeneABCA7C0546126Acute Confusional Senile Dementia2CTD_human
TgeneABCA7C0750900Alzheimer's Disease, Focal Onset2CTD_human
TgeneABCA7C0750901Alzheimer Disease, Early Onset2CTD_human
TgeneABCA7C0235874Disease Exacerbation1CTD_human