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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GHRLOS-GHRL (FusionGDB2 ID:32963)

Fusion Gene Summary for GHRLOS-GHRL

check button Fusion gene summary
Fusion gene informationFusion gene name: GHRLOS-GHRL
Fusion gene ID: 32963
HgeneTgene
Gene symbol

GHRLOS

GHRL

Gene ID

100126793

51738

Gene nameghrelin opposite strand/antisense RNAghrelin and obestatin prepropeptide
SynonymsGHRL-AS1|GHRLAS|NCRNA00068MTLRP
Cytomap

3p25.3

3p25.3

Type of genencRNAprotein-coding
DescriptionGHRL antisense RNA 1 (non-protein coding)appetite-regulating hormoneIn2c-preproghrelinghrelin, growth hormone secretagogue receptor ligandghrelin/obestatin preprohormoneghrelin/obestatin prepropeptidegrowth hormone-releasing peptidemotilin-related peptideprepro-appetite regulatory hormone
Modification date2020031320200329
UniProtAcc.

Q9UBU3

Ensembl transtripts involved in fusion geneENST00000605105, ENST00000605014, 
ENST00000439539, ENST00000603771, 
ENST00000335542, ENST00000430179, 
ENST00000422159, ENST00000450603, 
ENST00000449554, ENST00000446937, 
ENST00000457360, ENST00000437422, 
ENST00000439975, ENST00000287656, 
ENST00000449238, ENST00000429122, 
ENST00000476283, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 3 X 3=36
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GHRLOS [Title/Abstract] AND GHRL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGHRLOS(10327537)-GHRL(10327578), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGHRL

GO:0001937

negative regulation of endothelial cell proliferation

15572208

TgeneGHRL

GO:0008154

actin polymerization or depolymerization

15232612

TgeneGHRL

GO:0009725

response to hormone

15232612

TgeneGHRL

GO:0016358

dendrite development

16491079

TgeneGHRL

GO:0032691

negative regulation of interleukin-1 beta production

15232612

TgeneGHRL

GO:0042127

regulation of cell proliferation

15564328|16394173

TgeneGHRL

GO:0042322

negative regulation of circadian sleep/wake cycle, REM sleep

18329818

TgeneGHRL

GO:0042536

negative regulation of tumor necrosis factor biosynthetic process

15232612

TgeneGHRL

GO:0043066

negative regulation of apoptotic process

15158140

TgeneGHRL

GO:0043627

response to estrogen

15292338

TgeneGHRL

GO:0045409

negative regulation of interleukin-6 biosynthetic process

15232612

TgeneGHRL

GO:0046010

positive regulation of circadian sleep/wake cycle, non-REM sleep

18329818

TgeneGHRL

GO:0046697

decidualization

17494105

TgeneGHRL

GO:0050728

negative regulation of inflammatory response

15232612

TgeneGHRL

GO:0051461

positive regulation of corticotropin secretion

12566947

TgeneGHRL

GO:0051464

positive regulation of cortisol secretion

12566947|18329818

TgeneGHRL

GO:0051965

positive regulation of synapse assembly

16491079

TgeneGHRL

GO:0060124

positive regulation of growth hormone secretion

12566947|18329818


check buttonFusion gene breakpoints across GHRLOS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GHRL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer115NdGHRLOSchr3

10327537

+GHRLchr3

10327578

-
ChimerDB4Non-Cancer119NdGHRLOSchr3

10327537

+GHRLchr3

10327578

-
ChimerDB4Non-Cancer167NGHRLOSchr3

10327537

+GHRLchr3

10327578

-
ChimerDB4Non-Cancer169NGHRLOSchr3

10327537

+GHRLchr3

10327578

-


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Fusion Gene ORF analysis for GHRLOS-GHRL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000605105ENST00000335542GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605105ENST00000430179GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605105ENST00000422159GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605105ENST00000450603GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605105ENST00000449554GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605105ENST00000446937GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605105ENST00000457360GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605105ENST00000437422GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605105ENST00000439975GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605105ENST00000287656GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605105ENST00000449238GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605105ENST00000429122GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-5UTRENST00000605105ENST00000476283GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605014ENST00000335542GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605014ENST00000430179GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605014ENST00000422159GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605014ENST00000450603GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605014ENST00000449554GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605014ENST00000446937GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605014ENST00000457360GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605014ENST00000437422GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605014ENST00000439975GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605014ENST00000287656GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605014ENST00000449238GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000605014ENST00000429122GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-5UTRENST00000605014ENST00000476283GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000439539ENST00000335542GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000439539ENST00000430179GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000439539ENST00000422159GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000439539ENST00000450603GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000439539ENST00000449554GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000439539ENST00000446937GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000439539ENST00000457360GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000439539ENST00000437422GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000439539ENST00000439975GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000439539ENST00000287656GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000439539ENST00000449238GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-3CDSENST00000439539ENST00000429122GHRLOSchr3

10327537

+GHRLchr3

10327578

-
3UTR-5UTRENST00000439539ENST00000476283GHRLOSchr3

10327537

+GHRLchr3

10327578

-
intron-3CDSENST00000603771ENST00000335542GHRLOSchr3

10327537

+GHRLchr3

10327578

-
intron-3CDSENST00000603771ENST00000430179GHRLOSchr3

10327537

+GHRLchr3

10327578

-
intron-3CDSENST00000603771ENST00000422159GHRLOSchr3

10327537

+GHRLchr3

10327578

-
intron-3CDSENST00000603771ENST00000450603GHRLOSchr3

10327537

+GHRLchr3

10327578

-
intron-3CDSENST00000603771ENST00000449554GHRLOSchr3

10327537

+GHRLchr3

10327578

-
intron-3CDSENST00000603771ENST00000446937GHRLOSchr3

10327537

+GHRLchr3

10327578

-
intron-3CDSENST00000603771ENST00000457360GHRLOSchr3

10327537

+GHRLchr3

10327578

-
intron-3CDSENST00000603771ENST00000437422GHRLOSchr3

10327537

+GHRLchr3

10327578

-
intron-3CDSENST00000603771ENST00000439975GHRLOSchr3

10327537

+GHRLchr3

10327578

-
intron-3CDSENST00000603771ENST00000287656GHRLOSchr3

10327537

+GHRLchr3

10327578

-
intron-3CDSENST00000603771ENST00000449238GHRLOSchr3

10327537

+GHRLchr3

10327578

-
intron-3CDSENST00000603771ENST00000429122GHRLOSchr3

10327537

+GHRLchr3

10327578

-
intron-5UTRENST00000603771ENST00000476283GHRLOSchr3

10327537

+GHRLchr3

10327578

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GHRLOS-GHRL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GHRLOS-GHRL


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GHRL

Q9UBU3

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.; FUNCTION: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GHRLOS-GHRL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GHRLOS-GHRL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GHRLOS-GHRL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GHRLOS-GHRL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGHRLC0038358Gastric ulcer2CTD_human
TgeneGHRLC0001418Adenocarcinoma1CTD_human
TgeneGHRLC0005974Bone Resorption1CTD_human
TgeneGHRLC0006625Cachexia1CTD_human
TgeneGHRLC0009171Cocaine Abuse1CTD_human
TgeneGHRLC0009319Colitis1CTD_human
TgeneGHRLC0009324Ulcerative Colitis1CTD_human
TgeneGHRLC0011573Endogenous depression1CTD_human
TgeneGHRLC0011581Depressive disorder1CTD_human
TgeneGHRLC0011999Diastematomyelia1CTD_human
TgeneGHRLC0014859Esophageal Neoplasms1CTD_human
TgeneGHRLC0018801Heart failure1CTD_human
TgeneGHRLC0018802Congestive heart failure1CTD_human
TgeneGHRLC0022333Jacksonian Seizure1CTD_human
TgeneGHRLC0023212Left-Sided Heart Failure1CTD_human
TgeneGHRLC0025193Melancholia1CTD_human
TgeneGHRLC0027746Nerve Degeneration1CTD_human
TgeneGHRLC0027794Neural Tube Defects1CTD_human
TgeneGHRLC0027806Neurenteric Cyst1CTD_human
TgeneGHRLC0035126Reperfusion Injury1CTD_human
TgeneGHRLC0036572Seizures1CTD_human
TgeneGHRLC0041696Unipolar Depression1CTD_human
TgeneGHRLC0043094Weight Gain1CTD_human
TgeneGHRLC0080218Tethered Cord Syndrome1CTD_human
TgeneGHRLC0086133Depressive Syndrome1CTD_human
TgeneGHRLC0149958Complex partial seizures1CTD_human
TgeneGHRLC0152234Iniencephaly1CTD_human
TgeneGHRLC0152426Craniorachischisis1CTD_human
TgeneGHRLC0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneGHRLC0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneGHRLC0205643Carcinoma, Cribriform1CTD_human
TgeneGHRLC0205644Carcinoma, Granular Cell1CTD_human
TgeneGHRLC0205645Adenocarcinoma, Tubular1CTD_human
TgeneGHRLC0234533Generalized seizures1CTD_human
TgeneGHRLC0234535Clonic Seizures1CTD_human
TgeneGHRLC0235527Heart Failure, Right-Sided1CTD_human
TgeneGHRLC0236736Cocaine-Related Disorders1CTD_human
TgeneGHRLC0266453Exencephaly1CTD_human
TgeneGHRLC0270824Visual seizure1CTD_human
TgeneGHRLC0270844Tonic Seizures1CTD_human
TgeneGHRLC0270846Epileptic drop attack1CTD_human
TgeneGHRLC0282126Depression, Neurotic1CTD_human
TgeneGHRLC0344479Spinal Cord Myelodysplasia1CTD_human
TgeneGHRLC0422850Seizures, Somatosensory1CTD_human
TgeneGHRLC0422852Seizures, Auditory1CTD_human
TgeneGHRLC0422853Olfactory seizure1CTD_human
TgeneGHRLC0422854Gustatory seizure1CTD_human
TgeneGHRLC0422855Vertiginous seizure1CTD_human
TgeneGHRLC0494475Tonic - clonic seizures1CTD_human
TgeneGHRLC0546837Malignant neoplasm of esophagus1CTD_human
TgeneGHRLC0600427Cocaine Dependence1CTD_human
TgeneGHRLC0687132heavy drinking1PSYGENET
TgeneGHRLC0702169Acrania1CTD_human
TgeneGHRLC0751056Non-epileptic convulsion1CTD_human
TgeneGHRLC0751110Single Seizure1CTD_human
TgeneGHRLC0751123Atonic Absence Seizures1CTD_human
TgeneGHRLC0751494Convulsive Seizures1CTD_human
TgeneGHRLC0751495Seizures, Focal1CTD_human
TgeneGHRLC0751496Seizures, Sensory1CTD_human
TgeneGHRLC1959583Myocardial Failure1CTD_human
TgeneGHRLC1961112Heart Decompensation1CTD_human
TgeneGHRLC3495874Nonepileptic Seizures1CTD_human
TgeneGHRLC4048158Convulsions1CTD_human
TgeneGHRLC4316903Absence Seizures1CTD_human
TgeneGHRLC4317109Epileptic Seizures1CTD_human
TgeneGHRLC4317123Myoclonic Seizures1CTD_human
TgeneGHRLC4505436Generalized Absence Seizures1CTD_human