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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GIPR-PRR12 (FusionGDB2 ID:33037)

Fusion Gene Summary for GIPR-PRR12

check button Fusion gene summary
Fusion gene informationFusion gene name: GIPR-PRR12
Fusion gene ID: 33037
HgeneTgene
Gene symbol

GIPR

PRR12

Gene ID

2696

57479

Gene namegastric inhibitory polypeptide receptorproline rich 12
SynonymsPGQTL2KIAA1205
Cytomap

19q13.32

19q13.33

Type of geneprotein-codingprotein-coding
Descriptiongastric inhibitory polypeptide receptorGIP-Rglucose-dependent insulinotropic polypeptide receptorproline-rich protein 12
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000590918, ENST00000263281, 
ENST00000304207, ENST00000593127, 
ENST00000418929, 
Fusion gene scores* DoF score5 X 3 X 4=605 X 4 X 4=80
# samples 55
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GIPR [Title/Abstract] AND PRR12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGIPR(46181484)-PRR12(50117790), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GIPR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PRR12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-67-4679-01BGIPRchr19

46181484

-PRR12chr19

50117790

+


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Fusion Gene ORF analysis for GIPR-PRR12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000590918ENST00000418929GIPRchr19

46181484

-PRR12chr19

50117790

+
In-frameENST00000263281ENST00000418929GIPRchr19

46181484

-PRR12chr19

50117790

+
In-frameENST00000304207ENST00000418929GIPRchr19

46181484

-PRR12chr19

50117790

+
intron-3CDSENST00000593127ENST00000418929GIPRchr19

46181484

-PRR12chr19

50117790

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000590918GIPRchr1946181484-ENST00000418929PRR12chr1950117790+34211251452588847
ENST00000263281GIPRchr1946181484-ENST00000418929PRR12chr1950117790+34091239332576847
ENST00000304207GIPRchr1946181484-ENST00000418929PRR12chr1950117790+33001130322467811

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000590918ENST00000418929GIPRchr1946181484-PRR12chr1950117790+0.002566160.99743384
ENST00000263281ENST00000418929GIPRchr1946181484-PRR12chr1950117790+0.0025107580.9974892
ENST00000304207ENST00000418929GIPRchr1946181484-PRR12chr1950117790+0.0021461880.9978538

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Fusion Genomic Features for GIPR-PRR12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GIPR-PRR12


check button Go to

FGviewer for the breakpoints of chr19:46181484-chr19:50117790

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGIPRchr19:46181484chr19:50117790ENST00000590918-1214162_169384.0467.0Topological domainCytoplasmic
HgeneGIPRchr19:46181484chr19:50117790ENST00000590918-1214190_217384.0467.0Topological domainExtracellular
HgeneGIPRchr19:46181484chr19:50117790ENST00000590918-121422_138384.0467.0Topological domainExtracellular
HgeneGIPRchr19:46181484chr19:50117790ENST00000590918-1214243_254384.0467.0Topological domainCytoplasmic
HgeneGIPRchr19:46181484chr19:50117790ENST00000590918-1214279_293384.0467.0Topological domainExtracellular
HgeneGIPRchr19:46181484chr19:50117790ENST00000590918-1214320_341384.0467.0Topological domainCytoplasmic
HgeneGIPRchr19:46181484chr19:50117790ENST00000590918-1214363_377384.0467.0Topological domainExtracellular
HgeneGIPRchr19:46181484chr19:50117790ENST00000590918-1214139_161384.0467.0TransmembraneHelical%3B Name%3D1
HgeneGIPRchr19:46181484chr19:50117790ENST00000590918-1214170_189384.0467.0TransmembraneHelical%3B Name%3D2
HgeneGIPRchr19:46181484chr19:50117790ENST00000590918-1214218_242384.0467.0TransmembraneHelical%3B Name%3D3
HgeneGIPRchr19:46181484chr19:50117790ENST00000590918-1214255_278384.0467.0TransmembraneHelical%3B Name%3D4
HgeneGIPRchr19:46181484chr19:50117790ENST00000590918-1214294_319384.0467.0TransmembraneHelical%3B Name%3D5
HgeneGIPRchr19:46181484chr19:50117790ENST00000590918-1214342_362384.0467.0TransmembraneHelical%3B Name%3D6
TgenePRR12chr19:46181484chr19:50117790ENST000004189295141666_17371591.02037.0Compositional biasPro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGIPRchr19:46181484chr19:50117790ENST00000590918-1214399_466384.0467.0Topological domainCytoplasmic
HgeneGIPRchr19:46181484chr19:50117790ENST00000590918-1214378_398384.0467.0TransmembraneHelical%3B Name%3D7
TgenePRR12chr19:46181484chr19:50117790ENST00000418929514161_3061591.02037.0Compositional biasPro-rich
TgenePRR12chr19:46181484chr19:50117790ENST00000418929514335_6851591.02037.0Compositional biasGly-rich
TgenePRR12chr19:46181484chr19:50117790ENST00000418929514764_15451591.02037.0Compositional biasPro-rich


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Fusion Gene Sequence for GIPR-PRR12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000590918_ENST00000418929_TCGA-67-4679-01B_GIPR_chr19_46181484_-_PRR12_chr19_50117790_length(transcript)=3421nt_BP=1251nt
GGCAGCGGTGGCAGGGGCTGCAGGAGCAAGTGACCAGGAGCAGGACTGGGGACAGGCCTGATCGCCCCTGCACGAACCAGACCCTTCGCC
GCCCTCACGATGACTACCTCTCCGATCCTGCAGCTGCTGCTGCGGCTCTCACTGTGCGGGCTGCTGCTCCAGAGGGCGGAGACAGGCTCT
AAGGGGCAGACGGCGGGGGAGCTGTACCAGCGCTGGGAACGGTACCGCAGGGAGTGCCAGGAGACCTTGGCAGCCGCGGAACCGCCTTCA
GGCCTCGCCTGTAACGGGTCCTTCGATATGTACGTCTGCTGGGACTATGCTGCACCCAATGCCACTGCCCGTGCGTCCTGCCCCTGGTAC
CTGCCCTGGCACCACCATGTGGCTGCAGGTTTCGTCCTCCGCCAGTGTGGCAGTGATGGCCAATGGGGACTTTGGAGAGACCATACACAA
TGTGAGAACCCAGAGAAGAATGAGGCCTTTCTGGACCAAAGGCTCATCTTGGAGCGGTTGCAGGTCATGTACACTGTCGGCTACTCCCTG
TCTCTCGCCACACTGCTGCTAGCCCTGCTCATCTTGAGTTTGTTCAGGCGGCTACATTGCACTAGAAACTATATCCACATCAACCTGTTC
ACGTCTTTCATGCTGCGAGCTGCGGCCATTCTCAGCCGAGACCGTCTGCTACCTCGACCTGGCCCCTACCTTGGGGACCAGGCCCTTGCG
CTGTGGAACCAGGCCCTCGCTGCCTGCCGCACGGCCCAGATCGTGACCCAGTACTGCGTGGGTGCCAACTACACGTGGCTGCTGGTGGAG
GGCGTCTACCTGCACAGTCTCCTGGTGCTCGTGGGAGGCTCCGAGGAGGGCCACTTCCGCTACTACCTGCTCCTCGGCTGGGGGGCCCCC
GCGCTTTTCGTCATTCCCTGGGTGATCGTCAGGTACCTGTACGAGAACACGCAGTGCTGGGAGCGCAACGAAGTCAAGGCCATTTGGTGG
ATTATACGGACCCCCATCCTCATGACCATCTTGATTAATTTCCTCATTTTTATCCGCATTCTTGGCATTCTCCTGTCCAAGCTGAGGACA
CGGCAAATGCGCTGCCGGGATTACCGGCTGAGGCTGGCTCGCTCCACGCTGACGCTGGTGCCCCTGCTGGGTGTCCACGAGGTGGTGTTT
GCTCCCGTGACAGAGGAACAGGCCCGGGGCGCCCTGCGCTTCGCCAAGCTCGGCTTTGAGATCTTCCTCAGCTCCTTCCAGCTGGCGTTG
CAGACGGGGCGTGAACCCCCACCCATCTGGCGAGTCCAGAAGGCCCTTCTGCAGAAATTCACTCCGGAGATCAAGGACGGCCAGAGGCAG
TTTTGTGCCACCAGTAATTATTTGGGGTATTTTGGGGATGCAAAAAATCGGTACCAGCGCCTCTATGTAAAGTTCCTGGAAAATGTCAAT
AAGAAGGACTACGTGAGGGTCTGTGCTCGGAAACCCTGGCATCGGCCCCCAGTGCCAGTCAGACGCTCTGGGCAGGCCAAGAACCCCGTA
TCTGCTGGGGGTAGCTCTGCACCTCCCCCTAAGGCCCCAGCACCACCTCCCAAGCCTGAGACCCCTGAAAAGACGACATCTGAGAAGCCC
CCAGAGCAGACTCCTGAGACGGCCATGCCTGAGCCCCCTGCCCCCGAGAAGCCCTCCCTCCTGCGGCCTGTTGAGAAGGAAAAGGAGAAG
GAGAAGGTGACACGTGGAGAGCGGCCATTGCGGGGTGAGCGGGCCACCAGCGGACGGCAGACACGGCCAGAGCGGAGTCTCGCCACGGGA
CAACCTGCCACATCCCGGCTGCCCAAAGCCCGGCCTACCAAGGTGAAGGCTGAACCGCCCCCTAAGAAGAGGAAGAAATGGCTGAAGGAG
GCAGGCGGCAACGCTACAGCAGGCGGGGGCCCACCAGGCAGCTCCTCGGACTCGGAGTCCTCCCCTGGAGCCCCCAGCGAGGACGAGCGG
GCAGTACCTGGGCGTCTGCTCAAAACCAGGGCGATGCGGGAGATGTACCGGAGCTACGTGGAGATGTTGGTGAGCACAGCACTTGACCCA
GACATGATCCAGGCCCTGGAGGACACGCATGACGAGCTGTACCTGCCCCCCATGCGGAAGATAGACGGCCTGCTGAATGAGCACAAGAAG
AAAGTCCTGAAGCGGCTGTCGCTAAGCCCAGCCCTGCAGGATGCTCTGCACACGTTCCCACAGCTGCAAGTGGAGCAGAGTGGGGAGGGC
TCTCCGGAAGAGGGGGCTGTGCGGCTGCGGCCTGCTGGGGAACCCTACAACCGCAAGACGCTCAGCAAGCTCAAGAGGAGCGTGGTCAGA
GCCCAGGAGTTCAAGGTTGAGCTGGAAAAGTCGGGATACTATACACTCTACCATTCGCTCCACCACTATAAATACCACACCTTCCTGCGC
TGCCGGGACCAGACCCTGGCCATCGAGGGCGGCGCCGAGGACCTGGGCCAGGAGGAGGTGGTCCAGCAGTGCATGCGGAACCAGCCGTGG
CTGGAACAGCTCTTTGACTCCTTCAGTGACCTGCTGGCCCAAGCACAGGCCCACAGCCGCTGCGGGTGACCCCGCCCCAGCTTGTGAGGG
GGGCGCCTCCTCCATGAACCGAGAATTGGGACAGAACCGTGTCCTCAGGAGCTAACACCTGGGCTCCATCGCCGGGGAAAGGGGGTCATG
GGTCAGGGTGTGTCTGTGCTGCCCCCTCCAGGGCAGGGTTCAAAGTCCGACTCCCCCCCTCTCCCAAGCCCCCTCCACTCCCTCCCCATT
CCTCCCACTGTTCGGTGTACAGAGAAATTATTTATATATATGTATAAATGTCTATTTAGTAACGGTTTCCCTCTCCCCTTGCCCCGACCC
CCCCTCCACAGCCACAGCCCCCGCCCCCTCCACCTTGTACATAATGTATAGGAAAAGTCTATGTATGGCTGGGGGGGGTGGGGTGGCTTC
AGAGAGCTGGGGGACCCCTTCCCCCCAAGTCCCCCCTGCAGGCCAAGATCTTTGCTAAAGGCCATTCCCTCCGCAGGGCATTTGGCGTCG
GGTGGGAGGGGAAAACGCATCTTGTTAATTATTTTTAATCTTATTTATTGTACATACCTGGGGCAGGGGCTTGGGGAGGTGGAGGGGGGA
GAAGGGTCCCCTCTCTCTGCCCCTCCCACTCCTTTTCTACGGCGATTTGTCTGTGTCTGGCCCCCACCCACTGCCCATCCCCCATTGTTG
TCTGGATGTGGTTCTATTTTTTATCGGTCTCCTTTCCCCTCCTCCCCGTTCTCGCCCCCGCCCCACCCCCTGCTCCCACTACCCTTTGTC
TCTTGCTCTTTCTTGGGCTTCTGTACAACTCAACTTGTATACACTGTGTACACACAACCAGCCAAACGAAAACCCAACGGCAAACACTTT

>In-frame_ENST00000590918_ENST00000418929_TCGA-67-4679-01B_GIPR_chr19_46181484_-_PRR12_chr19_50117790_length(amino acids)=847AA_start in transcript=45_stop in transcript=2588
MGTGLIAPARTRPFAALTMTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWD
YAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLF
RRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSE
EGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARS
TLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQLALQTGREPPPIWRVQKALLQKFTPEIKDGQRQFCATSNYLGYFGDAK
NRYQRLYVKFLENVNKKDYVRVCARKPWHRPPVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAP
EKPSLLRPVEKEKEKEKVTRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARPTKVKAEPPPKKRKKWLKEAGGNATAGGGPPGSS
SDSESSPGAPSEDERAVPGRLLKTRAMREMYRSYVEMLVSTALDPDMIQALEDTHDELYLPPMRKIDGLLNEHKKKVLKRLSLSPALQDA
LHTFPQLQVEQSGEGSPEEGAVRLRPAGEPYNRKTLSKLKRSVVRAQEFKVELEKSGYYTLYHSLHHYKYHTFLRCRDQTLAIEGGAEDL

--------------------------------------------------------------
>In-frame_ENST00000263281_ENST00000418929_TCGA-67-4679-01B_GIPR_chr19_46181484_-_PRR12_chr19_50117790_length(transcript)=3409nt_BP=1239nt
AGGGGCTGCAGGAGCAAGTGACCAGGAGCAGGACTGGGGACAGGCCTGATCGCCCCTGCACGAACCAGACCCTTCGCCGCCCTCACGATG
ACTACCTCTCCGATCCTGCAGCTGCTGCTGCGGCTCTCACTGTGCGGGCTGCTGCTCCAGAGGGCGGAGACAGGCTCTAAGGGGCAGACG
GCGGGGGAGCTGTACCAGCGCTGGGAACGGTACCGCAGGGAGTGCCAGGAGACCTTGGCAGCCGCGGAACCGCCTTCAGGCCTCGCCTGT
AACGGGTCCTTCGATATGTACGTCTGCTGGGACTATGCTGCACCCAATGCCACTGCCCGTGCGTCCTGCCCCTGGTACCTGCCCTGGCAC
CACCATGTGGCTGCAGGTTTCGTCCTCCGCCAGTGTGGCAGTGATGGCCAATGGGGACTTTGGAGAGACCATACACAATGTGAGAACCCA
GAGAAGAATGAGGCCTTTCTGGACCAAAGGCTCATCTTGGAGCGGTTGCAGGTCATGTACACTGTCGGCTACTCCCTGTCTCTCGCCACA
CTGCTGCTAGCCCTGCTCATCTTGAGTTTGTTCAGGCGGCTACATTGCACTAGAAACTATATCCACATCAACCTGTTCACGTCTTTCATG
CTGCGAGCTGCGGCCATTCTCAGCCGAGACCGTCTGCTACCTCGACCTGGCCCCTACCTTGGGGACCAGGCCCTTGCGCTGTGGAACCAG
GCCCTCGCTGCCTGCCGCACGGCCCAGATCGTGACCCAGTACTGCGTGGGTGCCAACTACACGTGGCTGCTGGTGGAGGGCGTCTACCTG
CACAGTCTCCTGGTGCTCGTGGGAGGCTCCGAGGAGGGCCACTTCCGCTACTACCTGCTCCTCGGCTGGGGGGCCCCCGCGCTTTTCGTC
ATTCCCTGGGTGATCGTCAGGTACCTGTACGAGAACACGCAGTGCTGGGAGCGCAACGAAGTCAAGGCCATTTGGTGGATTATACGGACC
CCCATCCTCATGACCATCTTGATTAATTTCCTCATTTTTATCCGCATTCTTGGCATTCTCCTGTCCAAGCTGAGGACACGGCAAATGCGC
TGCCGGGATTACCGGCTGAGGCTGGCTCGCTCCACGCTGACGCTGGTGCCCCTGCTGGGTGTCCACGAGGTGGTGTTTGCTCCCGTGACA
GAGGAACAGGCCCGGGGCGCCCTGCGCTTCGCCAAGCTCGGCTTTGAGATCTTCCTCAGCTCCTTCCAGCTGGCGTTGCAGACGGGGCGT
GAACCCCCACCCATCTGGCGAGTCCAGAAGGCCCTTCTGCAGAAATTCACTCCGGAGATCAAGGACGGCCAGAGGCAGTTTTGTGCCACC
AGTAATTATTTGGGGTATTTTGGGGATGCAAAAAATCGGTACCAGCGCCTCTATGTAAAGTTCCTGGAAAATGTCAATAAGAAGGACTAC
GTGAGGGTCTGTGCTCGGAAACCCTGGCATCGGCCCCCAGTGCCAGTCAGACGCTCTGGGCAGGCCAAGAACCCCGTATCTGCTGGGGGT
AGCTCTGCACCTCCCCCTAAGGCCCCAGCACCACCTCCCAAGCCTGAGACCCCTGAAAAGACGACATCTGAGAAGCCCCCAGAGCAGACT
CCTGAGACGGCCATGCCTGAGCCCCCTGCCCCCGAGAAGCCCTCCCTCCTGCGGCCTGTTGAGAAGGAAAAGGAGAAGGAGAAGGTGACA
CGTGGAGAGCGGCCATTGCGGGGTGAGCGGGCCACCAGCGGACGGCAGACACGGCCAGAGCGGAGTCTCGCCACGGGACAACCTGCCACA
TCCCGGCTGCCCAAAGCCCGGCCTACCAAGGTGAAGGCTGAACCGCCCCCTAAGAAGAGGAAGAAATGGCTGAAGGAGGCAGGCGGCAAC
GCTACAGCAGGCGGGGGCCCACCAGGCAGCTCCTCGGACTCGGAGTCCTCCCCTGGAGCCCCCAGCGAGGACGAGCGGGCAGTACCTGGG
CGTCTGCTCAAAACCAGGGCGATGCGGGAGATGTACCGGAGCTACGTGGAGATGTTGGTGAGCACAGCACTTGACCCAGACATGATCCAG
GCCCTGGAGGACACGCATGACGAGCTGTACCTGCCCCCCATGCGGAAGATAGACGGCCTGCTGAATGAGCACAAGAAGAAAGTCCTGAAG
CGGCTGTCGCTAAGCCCAGCCCTGCAGGATGCTCTGCACACGTTCCCACAGCTGCAAGTGGAGCAGAGTGGGGAGGGCTCTCCGGAAGAG
GGGGCTGTGCGGCTGCGGCCTGCTGGGGAACCCTACAACCGCAAGACGCTCAGCAAGCTCAAGAGGAGCGTGGTCAGAGCCCAGGAGTTC
AAGGTTGAGCTGGAAAAGTCGGGATACTATACACTCTACCATTCGCTCCACCACTATAAATACCACACCTTCCTGCGCTGCCGGGACCAG
ACCCTGGCCATCGAGGGCGGCGCCGAGGACCTGGGCCAGGAGGAGGTGGTCCAGCAGTGCATGCGGAACCAGCCGTGGCTGGAACAGCTC
TTTGACTCCTTCAGTGACCTGCTGGCCCAAGCACAGGCCCACAGCCGCTGCGGGTGACCCCGCCCCAGCTTGTGAGGGGGGCGCCTCCTC
CATGAACCGAGAATTGGGACAGAACCGTGTCCTCAGGAGCTAACACCTGGGCTCCATCGCCGGGGAAAGGGGGTCATGGGTCAGGGTGTG
TCTGTGCTGCCCCCTCCAGGGCAGGGTTCAAAGTCCGACTCCCCCCCTCTCCCAAGCCCCCTCCACTCCCTCCCCATTCCTCCCACTGTT
CGGTGTACAGAGAAATTATTTATATATATGTATAAATGTCTATTTAGTAACGGTTTCCCTCTCCCCTTGCCCCGACCCCCCCTCCACAGC
CACAGCCCCCGCCCCCTCCACCTTGTACATAATGTATAGGAAAAGTCTATGTATGGCTGGGGGGGGTGGGGTGGCTTCAGAGAGCTGGGG
GACCCCTTCCCCCCAAGTCCCCCCTGCAGGCCAAGATCTTTGCTAAAGGCCATTCCCTCCGCAGGGCATTTGGCGTCGGGTGGGAGGGGA
AAACGCATCTTGTTAATTATTTTTAATCTTATTTATTGTACATACCTGGGGCAGGGGCTTGGGGAGGTGGAGGGGGGAGAAGGGTCCCCT
CTCTCTGCCCCTCCCACTCCTTTTCTACGGCGATTTGTCTGTGTCTGGCCCCCACCCACTGCCCATCCCCCATTGTTGTCTGGATGTGGT
TCTATTTTTTATCGGTCTCCTTTCCCCTCCTCCCCGTTCTCGCCCCCGCCCCACCCCCTGCTCCCACTACCCTTTGTCTCTTGCTCTTTC

>In-frame_ENST00000263281_ENST00000418929_TCGA-67-4679-01B_GIPR_chr19_46181484_-_PRR12_chr19_50117790_length(amino acids)=847AA_start in transcript=33_stop in transcript=2576
MGTGLIAPARTRPFAALTMTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWD
YAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLF
RRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSE
EGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARS
TLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQLALQTGREPPPIWRVQKALLQKFTPEIKDGQRQFCATSNYLGYFGDAK
NRYQRLYVKFLENVNKKDYVRVCARKPWHRPPVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAP
EKPSLLRPVEKEKEKEKVTRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARPTKVKAEPPPKKRKKWLKEAGGNATAGGGPPGSS
SDSESSPGAPSEDERAVPGRLLKTRAMREMYRSYVEMLVSTALDPDMIQALEDTHDELYLPPMRKIDGLLNEHKKKVLKRLSLSPALQDA
LHTFPQLQVEQSGEGSPEEGAVRLRPAGEPYNRKTLSKLKRSVVRAQEFKVELEKSGYYTLYHSLHHYKYHTFLRCRDQTLAIEGGAEDL

--------------------------------------------------------------
>In-frame_ENST00000304207_ENST00000418929_TCGA-67-4679-01B_GIPR_chr19_46181484_-_PRR12_chr19_50117790_length(transcript)=3300nt_BP=1130nt
GGGGCTGCAGGAGCAAGTGACCAGGAGCAGGACTGGGGACAGGCCTGATCGCCCCTGCACGAACCAGACCCTTCGCCGCCCTCACGATGA
CTACCTCTCCGATCCTGCAGCTGCTGCTGCGGCTCTCACTGTGCGGGCTGCTGCTCCAGAGGGCGGAGACAGGCTCTAAGGGGCAGACGG
CGGGGGAGCTGTACCAGCGCTGGGAACGGTACCGCAGGGAGTGCCAGGAGACCTTGGCAGCCGCGGAACCGCCTTCAGTGGCTGCAGGTT
TCGTCCTCCGCCAGTGTGGCAGTGATGGCCAATGGGGACTTTGGAGAGACCATACACAATGTGAGAACCCAGAGAAGAATGAGGCCTTTC
TGGACCAAAGGCTCATCTTGGAGCGGTTGCAGGTCATGTACACTGTCGGCTACTCCCTGTCTCTCGCCACACTGCTGCTAGCCCTGCTCA
TCTTGAGTTTGTTCAGGCGGCTACATTGCACTAGAAACTATATCCACATCAACCTGTTCACGTCTTTCATGCTGCGAGCTGCGGCCATTC
TCAGCCGAGACCGTCTGCTACCTCGACCTGGCCCCTACCTTGGGGACCAGGCCCTTGCGCTGTGGAACCAGGCCCTCGCTGCCTGCCGCA
CGGCCCAGATCGTGACCCAGTACTGCGTGGGTGCCAACTACACGTGGCTGCTGGTGGAGGGCGTCTACCTGCACAGTCTCCTGGTGCTCG
TGGGAGGCTCCGAGGAGGGCCACTTCCGCTACTACCTGCTCCTCGGCTGGGGGGCCCCCGCGCTTTTCGTCATTCCCTGGGTGATCGTCA
GGTACCTGTACGAGAACACGCAGTGCTGGGAGCGCAACGAAGTCAAGGCCATTTGGTGGATTATACGGACCCCCATCCTCATGACCATCT
TGATTAATTTCCTCATTTTTATCCGCATTCTTGGCATTCTCCTGTCCAAGCTGAGGACACGGCAAATGCGCTGCCGGGATTACCGGCTGA
GGCTGGCTCGCTCCACGCTGACGCTGGTGCCCCTGCTGGGTGTCCACGAGGTGGTGTTTGCTCCCGTGACAGAGGAACAGGCCCGGGGCG
CCCTGCGCTTCGCCAAGCTCGGCTTTGAGATCTTCCTCAGCTCCTTCCAGCTGGCGTTGCAGACGGGGCGTGAACCCCCACCCATCTGGC
GAGTCCAGAAGGCCCTTCTGCAGAAATTCACTCCGGAGATCAAGGACGGCCAGAGGCAGTTTTGTGCCACCAGTAATTATTTGGGGTATT
TTGGGGATGCAAAAAATCGGTACCAGCGCCTCTATGTAAAGTTCCTGGAAAATGTCAATAAGAAGGACTACGTGAGGGTCTGTGCTCGGA
AACCCTGGCATCGGCCCCCAGTGCCAGTCAGACGCTCTGGGCAGGCCAAGAACCCCGTATCTGCTGGGGGTAGCTCTGCACCTCCCCCTA
AGGCCCCAGCACCACCTCCCAAGCCTGAGACCCCTGAAAAGACGACATCTGAGAAGCCCCCAGAGCAGACTCCTGAGACGGCCATGCCTG
AGCCCCCTGCCCCCGAGAAGCCCTCCCTCCTGCGGCCTGTTGAGAAGGAAAAGGAGAAGGAGAAGGTGACACGTGGAGAGCGGCCATTGC
GGGGTGAGCGGGCCACCAGCGGACGGCAGACACGGCCAGAGCGGAGTCTCGCCACGGGACAACCTGCCACATCCCGGCTGCCCAAAGCCC
GGCCTACCAAGGTGAAGGCTGAACCGCCCCCTAAGAAGAGGAAGAAATGGCTGAAGGAGGCAGGCGGCAACGCTACAGCAGGCGGGGGCC
CACCAGGCAGCTCCTCGGACTCGGAGTCCTCCCCTGGAGCCCCCAGCGAGGACGAGCGGGCAGTACCTGGGCGTCTGCTCAAAACCAGGG
CGATGCGGGAGATGTACCGGAGCTACGTGGAGATGTTGGTGAGCACAGCACTTGACCCAGACATGATCCAGGCCCTGGAGGACACGCATG
ACGAGCTGTACCTGCCCCCCATGCGGAAGATAGACGGCCTGCTGAATGAGCACAAGAAGAAAGTCCTGAAGCGGCTGTCGCTAAGCCCAG
CCCTGCAGGATGCTCTGCACACGTTCCCACAGCTGCAAGTGGAGCAGAGTGGGGAGGGCTCTCCGGAAGAGGGGGCTGTGCGGCTGCGGC
CTGCTGGGGAACCCTACAACCGCAAGACGCTCAGCAAGCTCAAGAGGAGCGTGGTCAGAGCCCAGGAGTTCAAGGTTGAGCTGGAAAAGT
CGGGATACTATACACTCTACCATTCGCTCCACCACTATAAATACCACACCTTCCTGCGCTGCCGGGACCAGACCCTGGCCATCGAGGGCG
GCGCCGAGGACCTGGGCCAGGAGGAGGTGGTCCAGCAGTGCATGCGGAACCAGCCGTGGCTGGAACAGCTCTTTGACTCCTTCAGTGACC
TGCTGGCCCAAGCACAGGCCCACAGCCGCTGCGGGTGACCCCGCCCCAGCTTGTGAGGGGGGCGCCTCCTCCATGAACCGAGAATTGGGA
CAGAACCGTGTCCTCAGGAGCTAACACCTGGGCTCCATCGCCGGGGAAAGGGGGTCATGGGTCAGGGTGTGTCTGTGCTGCCCCCTCCAG
GGCAGGGTTCAAAGTCCGACTCCCCCCCTCTCCCAAGCCCCCTCCACTCCCTCCCCATTCCTCCCACTGTTCGGTGTACAGAGAAATTAT
TTATATATATGTATAAATGTCTATTTAGTAACGGTTTCCCTCTCCCCTTGCCCCGACCCCCCCTCCACAGCCACAGCCCCCGCCCCCTCC
ACCTTGTACATAATGTATAGGAAAAGTCTATGTATGGCTGGGGGGGGTGGGGTGGCTTCAGAGAGCTGGGGGACCCCTTCCCCCCAAGTC
CCCCCTGCAGGCCAAGATCTTTGCTAAAGGCCATTCCCTCCGCAGGGCATTTGGCGTCGGGTGGGAGGGGAAAACGCATCTTGTTAATTA
TTTTTAATCTTATTTATTGTACATACCTGGGGCAGGGGCTTGGGGAGGTGGAGGGGGGAGAAGGGTCCCCTCTCTCTGCCCCTCCCACTC
CTTTTCTACGGCGATTTGTCTGTGTCTGGCCCCCACCCACTGCCCATCCCCCATTGTTGTCTGGATGTGGTTCTATTTTTTATCGGTCTC
CTTTCCCCTCCTCCCCGTTCTCGCCCCCGCCCCACCCCCTGCTCCCACTACCCTTTGTCTCTTGCTCTTTCTTGGGCTTCTGTACAACTC

>In-frame_ENST00000304207_ENST00000418929_TCGA-67-4679-01B_GIPR_chr19_46181484_-_PRR12_chr19_50117790_length(amino acids)=811AA_start in transcript=32_stop in transcript=2467
MGTGLIAPARTRPFAALTMTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSVAAGFVLRQCGSDGQ
WGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPG
PYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWE
RNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEI
FLSSFQLALQTGREPPPIWRVQKALLQKFTPEIKDGQRQFCATSNYLGYFGDAKNRYQRLYVKFLENVNKKDYVRVCARKPWHRPPVPVR
RSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPEKPSLLRPVEKEKEKEKVTRGERPLRGERATSGRQT
RPERSLATGQPATSRLPKARPTKVKAEPPPKKRKKWLKEAGGNATAGGGPPGSSSDSESSPGAPSEDERAVPGRLLKTRAMREMYRSYVE
MLVSTALDPDMIQALEDTHDELYLPPMRKIDGLLNEHKKKVLKRLSLSPALQDALHTFPQLQVEQSGEGSPEEGAVRLRPAGEPYNRKTL
SKLKRSVVRAQEFKVELEKSGYYTLYHSLHHYKYHTFLRCRDQTLAIEGGAEDLGQEEVVQQCMRNQPWLEQLFDSFSDLLAQAQAHSRC

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Fusion Gene PPI Analysis for GIPR-PRR12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GIPR-PRR12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GIPR-PRR12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGIPRC0005910Body Weight1CTD_human
HgeneGIPRC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgenePRR12C0233514Abnormal behavior1GENOMICS_ENGLAND
TgenePRR12C0557874Global developmental delay1GENOMICS_ENGLAND
TgenePRR12C3714756Intellectual Disability1GENOMICS_ENGLAND
TgenePRR12C4025845Abnormality iris morphology1GENOMICS_ENGLAND
TgenePRR12C4025846Abnormality of vision1GENOMICS_ENGLAND