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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:GMDS-EEF1E1 (FusionGDB2 ID:33336) |
Fusion Gene Summary for GMDS-EEF1E1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: GMDS-EEF1E1 | Fusion gene ID: 33336 | Hgene | Tgene | Gene symbol | GMDS | EEF1E1 | Gene ID | 2762 | 9521 |
Gene name | GDP-mannose 4,6-dehydratase | eukaryotic translation elongation factor 1 epsilon 1 | |
Synonyms | GMD|SDR3E1 | AIMP3|P18 | |
Cytomap | 6p25.3 | 6p24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | GDP-mannose 4,6 dehydrataseGDP-D-mannose dehydrataseshort chain dehydrogenase/reductase family 3E, member 1 | eukaryotic translation elongation factor 1 epsilon-1ARS-interacting multifunctional protein 3aminoacyl tRNA synthetase complex-interacting multifunctional protein 3multisynthase complex auxiliary component p18p18 component of aminoacyl-tRNA synthetase | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | O43324 | |
Ensembl transtripts involved in fusion gene | ENST00000530927, ENST00000380815, ENST00000467288, | ENST00000429723, ENST00000379715, ENST00000507463, | |
Fusion gene scores | * DoF score | 28 X 19 X 15=7980 | 5 X 2 X 5=50 |
# samples | 32 | 5 | |
** MAII score | log2(32/7980*10)=-4.64024493622235 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/50*10)=0 | |
Context | PubMed: GMDS [Title/Abstract] AND EEF1E1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | GMDS(2116005)-EEF1E1(8097700), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GMDS | GO:0019673 | GDP-mannose metabolic process | 9525924 |
Hgene | GMDS | GO:0042351 | 'de novo' GDP-L-fucose biosynthetic process | 9525924 |
Tgene | EEF1E1 | GO:2000774 | positive regulation of cellular senescence | 25465621 |
Fusion gene breakpoints across GMDS (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across EEF1E1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | COAD | TCGA-A6-6654-01A | GMDS | chr6 | 2116005 | - | EEF1E1 | chr6 | 8097700 | - |
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Fusion Gene ORF analysis for GMDS-EEF1E1 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000530927 | ENST00000429723 | GMDS | chr6 | 2116005 | - | EEF1E1 | chr6 | 8097700 | - |
In-frame | ENST00000530927 | ENST00000379715 | GMDS | chr6 | 2116005 | - | EEF1E1 | chr6 | 8097700 | - |
In-frame | ENST00000530927 | ENST00000507463 | GMDS | chr6 | 2116005 | - | EEF1E1 | chr6 | 8097700 | - |
In-frame | ENST00000380815 | ENST00000429723 | GMDS | chr6 | 2116005 | - | EEF1E1 | chr6 | 8097700 | - |
In-frame | ENST00000380815 | ENST00000379715 | GMDS | chr6 | 2116005 | - | EEF1E1 | chr6 | 8097700 | - |
In-frame | ENST00000380815 | ENST00000507463 | GMDS | chr6 | 2116005 | - | EEF1E1 | chr6 | 8097700 | - |
intron-3CDS | ENST00000467288 | ENST00000429723 | GMDS | chr6 | 2116005 | - | EEF1E1 | chr6 | 8097700 | - |
intron-3CDS | ENST00000467288 | ENST00000379715 | GMDS | chr6 | 2116005 | - | EEF1E1 | chr6 | 8097700 | - |
intron-3CDS | ENST00000467288 | ENST00000507463 | GMDS | chr6 | 2116005 | - | EEF1E1 | chr6 | 8097700 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000530927 | GMDS | chr6 | 2116005 | - | ENST00000429723 | EEF1E1 | chr6 | 8097700 | - | 751 | 303 | 48 | 635 | 195 |
ENST00000530927 | GMDS | chr6 | 2116005 | - | ENST00000379715 | EEF1E1 | chr6 | 8097700 | - | 1236 | 303 | 48 | 740 | 230 |
ENST00000530927 | GMDS | chr6 | 2116005 | - | ENST00000507463 | EEF1E1 | chr6 | 8097700 | - | 832 | 303 | 48 | 668 | 206 |
ENST00000380815 | GMDS | chr6 | 2116005 | - | ENST00000429723 | EEF1E1 | chr6 | 8097700 | - | 1063 | 615 | 42 | 947 | 301 |
ENST00000380815 | GMDS | chr6 | 2116005 | - | ENST00000379715 | EEF1E1 | chr6 | 8097700 | - | 1548 | 615 | 42 | 1052 | 336 |
ENST00000380815 | GMDS | chr6 | 2116005 | - | ENST00000507463 | EEF1E1 | chr6 | 8097700 | - | 1144 | 615 | 42 | 980 | 312 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000530927 | ENST00000429723 | GMDS | chr6 | 2116005 | - | EEF1E1 | chr6 | 8097700 | - | 0.002389046 | 0.9976109 |
ENST00000530927 | ENST00000379715 | GMDS | chr6 | 2116005 | - | EEF1E1 | chr6 | 8097700 | - | 0.000399268 | 0.9996007 |
ENST00000530927 | ENST00000507463 | GMDS | chr6 | 2116005 | - | EEF1E1 | chr6 | 8097700 | - | 0.001205164 | 0.9987948 |
ENST00000380815 | ENST00000429723 | GMDS | chr6 | 2116005 | - | EEF1E1 | chr6 | 8097700 | - | 0.002093946 | 0.9979061 |
ENST00000380815 | ENST00000379715 | GMDS | chr6 | 2116005 | - | EEF1E1 | chr6 | 8097700 | - | 0.000676043 | 0.99932396 |
ENST00000380815 | ENST00000507463 | GMDS | chr6 | 2116005 | - | EEF1E1 | chr6 | 8097700 | - | 0.001288467 | 0.9987116 |
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Fusion Genomic Features for GMDS-EEF1E1 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for GMDS-EEF1E1 |
Go to FGviewer for the breakpoints of chr6:2116005-chr6:8097700 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | EEF1E1 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Positive modulator of ATM response to DNA damage. {ECO:0000250|UniProtKB:Q9D1M4}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | GMDS | chr6:2116005 | chr6:8097700 | ENST00000380815 | - | 4 | 11 | 108_112 | 115.0 | 373.0 | Nucleotide binding | NADP |
Hgene | GMDS | chr6:2116005 | chr6:8097700 | ENST00000380815 | - | 4 | 11 | 30_35 | 115.0 | 373.0 | Nucleotide binding | NADP |
Hgene | GMDS | chr6:2116005 | chr6:8097700 | ENST00000380815 | - | 4 | 11 | 55_58 | 115.0 | 373.0 | Nucleotide binding | NADP |
Hgene | GMDS | chr6:2116005 | chr6:8097700 | ENST00000380815 | - | 4 | 11 | 86_87 | 115.0 | 373.0 | Nucleotide binding | NADP |
Hgene | GMDS | chr6:2116005 | chr6:8097700 | ENST00000530927 | - | 4 | 11 | 30_35 | 85.0 | 343.0 | Nucleotide binding | NADP |
Hgene | GMDS | chr6:2116005 | chr6:8097700 | ENST00000530927 | - | 4 | 11 | 55_58 | 85.0 | 343.0 | Nucleotide binding | NADP |
Hgene | GMDS | chr6:2116005 | chr6:8097700 | ENST00000530927 | - | 4 | 11 | 86_87 | 85.0 | 343.0 | Nucleotide binding | NADP |
Tgene | EEF1E1 | chr6:2116005 | chr6:8097700 | ENST00000379715 | 0 | 4 | 153_169 | 29.0 | 175.0 | Coiled coil | Ontology_term=ECO:0000269 | |
Tgene | EEF1E1 | chr6:2116005 | chr6:8097700 | ENST00000429723 | 0 | 4 | 153_169 | 29.0 | 140.0 | Coiled coil | Ontology_term=ECO:0000269 | |
Tgene | EEF1E1 | chr6:2116005 | chr6:8097700 | ENST00000379715 | 0 | 4 | 50_173 | 29.0 | 175.0 | Domain | Note=GST C-terminal | |
Tgene | EEF1E1 | chr6:2116005 | chr6:8097700 | ENST00000429723 | 0 | 4 | 50_173 | 29.0 | 140.0 | Domain | Note=GST C-terminal | |
Tgene | EEF1E1 | chr6:2116005 | chr6:8097700 | ENST00000379715 | 0 | 4 | 57_63 | 29.0 | 175.0 | Region | Note=Linker | |
Tgene | EEF1E1 | chr6:2116005 | chr6:8097700 | ENST00000379715 | 0 | 4 | 64_152 | 29.0 | 175.0 | Region | Note=C-terminal | |
Tgene | EEF1E1 | chr6:2116005 | chr6:8097700 | ENST00000429723 | 0 | 4 | 57_63 | 29.0 | 140.0 | Region | Note=Linker | |
Tgene | EEF1E1 | chr6:2116005 | chr6:8097700 | ENST00000429723 | 0 | 4 | 64_152 | 29.0 | 140.0 | Region | Note=C-terminal |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | GMDS | chr6:2116005 | chr6:8097700 | ENST00000530927 | - | 4 | 11 | 108_112 | 85.0 | 343.0 | Nucleotide binding | NADP |
Tgene | EEF1E1 | chr6:2116005 | chr6:8097700 | ENST00000379715 | 0 | 4 | 2_56 | 29.0 | 175.0 | Region | Note=N-terminal | |
Tgene | EEF1E1 | chr6:2116005 | chr6:8097700 | ENST00000429723 | 0 | 4 | 2_56 | 29.0 | 140.0 | Region | Note=N-terminal |
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Fusion Gene Sequence for GMDS-EEF1E1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000530927_ENST00000429723_TCGA-A6-6654-01A_GMDS_chr6_2116005_-_EEF1E1_chr6_8097700_length(transcript)=751nt_BP=303nt TGTACACAGGCAGTTTGTTGGGAGCGTTACCATTGCCTCTGGTTCCTCATGTGTAAAATGGATGGTTCCTACCTGGCTGAGTTCCTGCTG GAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTTAATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCT CACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGTACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAG ATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTCCAGTTCTTCAGACAAACAATGGTCCAAGTCTAACAGGATTGACTACTATAGCA GCTCATCTAGTCAAGCAAGCCAACAAAGAATATTTGCTGGGGAGTACTGCAGAAGAAAAAGCAATCGTTCAGCAGTGGTTAGAATACAGG GTCACTCAAGTAGATGGGCACTCCAGTAAAAATGACATCCACACACTGTTGAAGGATCTTAATTCATATCTTGAAGATAAAGTCTACCTT ACAGGGTATAACTTTACATTAGCAGATATACTATTGTACTATGGACTTCATCGCTTTATAATAAGGAAGCTGAGGCACACAGAGGTAGGG AACTAACCCAACATCATACAAGGAACTGAGATCAAGGAACTGAGATTCAAACACAAATGTCTGGCTCAAACTTACCTGTAAACTACTCTA >In-frame_ENST00000530927_ENST00000429723_TCGA-A6-6654-01A_GMDS_chr6_2116005_-_EEF1E1_chr6_8097700_length(amino acids)=195AA_start in transcript=48_stop in transcript=635 MCKMDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKIPVLQ TNNGPSLTGLTTIAAHLVKQANKEYLLGSTAEEKAIVQQWLEYRVTQVDGHSSKNDIHTLLKDLNSYLEDKVYLTGYNFTLADILLYYGL -------------------------------------------------------------- >In-frame_ENST00000530927_ENST00000379715_TCGA-A6-6654-01A_GMDS_chr6_2116005_-_EEF1E1_chr6_8097700_length(transcript)=1236nt_BP=303nt TGTACACAGGCAGTTTGTTGGGAGCGTTACCATTGCCTCTGGTTCCTCATGTGTAAAATGGATGGTTCCTACCTGGCTGAGTTCCTGCTG GAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTTAATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCT CACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGTACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAG ATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTCCAGTTCTTCAGACAAACAATGGTCCAAGTCTAACAGGATTGACTACTATAGCA GCTCATCTAGTCAAGCAAGCCAACAAAGAATATTTGCTGGGGAGTACTGCAGAAGAAAAAGCAATCGTTCAGCAGTGGTTAGAATACAGG GTCACTCAAGTAGATGGGCACTCCAGTAAAAATGACATCCACACACTGTTGAAGGATCTTAATTCATATCTTGAAGATAAAGTCTACCTT ACAGGGTATAACTTTACATTAGCAGATATACTATTGTACTATGGACTTCATCGCTTTATAGTTGACCTGACAGTTCAAGAAAAGGAGAAA TATCTTAATGTGTCTCGCTGGTTTTGTCACATTCAGCATTATCCAGGCATCAGGCAACATCTGTCTAGTGTTGTCTTCATCAAGAACAGA CTATATACTAATTCCCACTAGAAGCTGTCCATGCCATACAGAAGATCTATTAAAAATGTTTTAAATGGAAAATGTACTCTAGACCACAGG ACTAATGTAAATTAATATACAGTCATTCATTATTTGTTGAAGTTGATAGAATTTTTGAAGTGTAAACTTGTGTCTGAATGTTTTATTTGT TCTTTAGCTGAAGTTTTGCAATTTTTATGTCAAAATTCAATTGCTATTAAACAAGTTGAGATCCAGTTATAAATTAACCTTGTTTTTAGT AGATGACATTTATTTCAATAAAAGTTGCAAATCGGGCTTAATCTTAAAATTGGTGGTCATTTCAATGGTTGACATATTTGGCTATTTATT AACCTCTCTTTCATATTCTAAAATTCATTTTCCCCTTATGGATATTTATGGTAGTTTGTTAAGAACTGATAAATTGTGCCAAGGAAGCCA >In-frame_ENST00000530927_ENST00000379715_TCGA-A6-6654-01A_GMDS_chr6_2116005_-_EEF1E1_chr6_8097700_length(amino acids)=230AA_start in transcript=48_stop in transcript=740 MCKMDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKIPVLQ TNNGPSLTGLTTIAAHLVKQANKEYLLGSTAEEKAIVQQWLEYRVTQVDGHSSKNDIHTLLKDLNSYLEDKVYLTGYNFTLADILLYYGL -------------------------------------------------------------- >In-frame_ENST00000530927_ENST00000507463_TCGA-A6-6654-01A_GMDS_chr6_2116005_-_EEF1E1_chr6_8097700_length(transcript)=832nt_BP=303nt TGTACACAGGCAGTTTGTTGGGAGCGTTACCATTGCCTCTGGTTCCTCATGTGTAAAATGGATGGTTCCTACCTGGCTGAGTTCCTGCTG GAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTTAATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCT CACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGTACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAG ATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTCCAGTTCTTCAGACAAACAATGGTCCAAGTCTAACAGGATTGACTACTATAGCA GCTCATCTAGTCAAGCAAGCCAACAAAGAATATTTGCTGGGGAGTACTGCAGAAGAAAAAGCAATCGTTCAGCAGTGGTTAGAATACAGG GTCACTCAAGTAGATGGGCACTCCAGTAAAAATGACATCCACACACTGTTGAAGGATCTTAATTCATATCTTGAAGATAAAGTCTACCTT ACAGGGTATAACTTTACATTAGCAGATATACTATTGTACTATGGACTTCATCGCTTTATAGTGAGTATTTGTATAGTTACTGGCTTTTTT TCTGTAGTGTTGAGAATGATTTTTAAAACTTTGTCTTGAATTTAAATCAGATTTGCATTTTTGGCTTATCAAATAAAAATGAAAGGAATT CCTTTATACAAGGTGCCTTTTGTAACAAACCTGCACGTTGTGCACATGTACCCTAAAACTTAAAGTATAATAATAATAAAATTTAAAAAA >In-frame_ENST00000530927_ENST00000507463_TCGA-A6-6654-01A_GMDS_chr6_2116005_-_EEF1E1_chr6_8097700_length(amino acids)=206AA_start in transcript=48_stop in transcript=668 MCKMDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKIPVLQ TNNGPSLTGLTTIAAHLVKQANKEYLLGSTAEEKAIVQQWLEYRVTQVDGHSSKNDIHTLLKDLNSYLEDKVYLTGYNFTLADILLYYGL -------------------------------------------------------------- >In-frame_ENST00000380815_ENST00000429723_TCGA-A6-6654-01A_GMDS_chr6_2116005_-_EEF1E1_chr6_8097700_length(transcript)=1063nt_BP=615nt GACGCGAATGACGCTGCGCCAGTCAGGCCGCAGCCCCGCTGCTTGGCCCGTCGGGCCCGCCTTGGCCGGCTCGGCCCGCCCCCGGCCCTC CCTGCACGGCCTCCCGTGCGCCCCTGTCAGACTGTGGCGGCCGGTCGCGCGGTGCGCTCTCCCTCCCTGCCCGCAGCCTGGAGAGGCGCT TCGTGCTGCACACCCCCGCGTTCCTGCCGGCACCGCGCCTGCCCTCTGCCGCGCTCCGCCCTGCCGCCGACCGCACGCCCGCCGCGGGAC ATGGCACACGCACCGGCACGCTGCCCCAGCGCCCGGGGCTCCGGGGACGGCGAGATGGGCAAGCCCAGGAACGTGGCGCTCATCACCGGT ATCACAGGCCAGGATGGTTCCTACCTGGCTGAGTTCCTGCTGGAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTT AATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCTCACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGT ACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAGATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTCCAGTTCTTCAG ACAAACAATGGTCCAAGTCTAACAGGATTGACTACTATAGCAGCTCATCTAGTCAAGCAAGCCAACAAAGAATATTTGCTGGGGAGTACT GCAGAAGAAAAAGCAATCGTTCAGCAGTGGTTAGAATACAGGGTCACTCAAGTAGATGGGCACTCCAGTAAAAATGACATCCACACACTG TTGAAGGATCTTAATTCATATCTTGAAGATAAAGTCTACCTTACAGGGTATAACTTTACATTAGCAGATATACTATTGTACTATGGACTT CATCGCTTTATAATAAGGAAGCTGAGGCACACAGAGGTAGGGAACTAACCCAACATCATACAAGGAACTGAGATCAAGGAACTGAGATTC >In-frame_ENST00000380815_ENST00000429723_TCGA-A6-6654-01A_GMDS_chr6_2116005_-_EEF1E1_chr6_8097700_length(amino acids)=301AA_start in transcript=42_stop in transcript=947 MARRARLGRLGPPPALPARPPVRPCQTVAAGRAVRSPSLPAAWRGASCCTPPRSCRHRACPLPRSALPPTARPPRDMAHAPARCPSARGS GDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTE IYNLGAQSHVKIPVLQTNNGPSLTGLTTIAAHLVKQANKEYLLGSTAEEKAIVQQWLEYRVTQVDGHSSKNDIHTLLKDLNSYLEDKVYL -------------------------------------------------------------- >In-frame_ENST00000380815_ENST00000379715_TCGA-A6-6654-01A_GMDS_chr6_2116005_-_EEF1E1_chr6_8097700_length(transcript)=1548nt_BP=615nt GACGCGAATGACGCTGCGCCAGTCAGGCCGCAGCCCCGCTGCTTGGCCCGTCGGGCCCGCCTTGGCCGGCTCGGCCCGCCCCCGGCCCTC CCTGCACGGCCTCCCGTGCGCCCCTGTCAGACTGTGGCGGCCGGTCGCGCGGTGCGCTCTCCCTCCCTGCCCGCAGCCTGGAGAGGCGCT TCGTGCTGCACACCCCCGCGTTCCTGCCGGCACCGCGCCTGCCCTCTGCCGCGCTCCGCCCTGCCGCCGACCGCACGCCCGCCGCGGGAC ATGGCACACGCACCGGCACGCTGCCCCAGCGCCCGGGGCTCCGGGGACGGCGAGATGGGCAAGCCCAGGAACGTGGCGCTCATCACCGGT ATCACAGGCCAGGATGGTTCCTACCTGGCTGAGTTCCTGCTGGAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTT AATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCTCACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGT ACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAGATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTCCAGTTCTTCAG ACAAACAATGGTCCAAGTCTAACAGGATTGACTACTATAGCAGCTCATCTAGTCAAGCAAGCCAACAAAGAATATTTGCTGGGGAGTACT GCAGAAGAAAAAGCAATCGTTCAGCAGTGGTTAGAATACAGGGTCACTCAAGTAGATGGGCACTCCAGTAAAAATGACATCCACACACTG TTGAAGGATCTTAATTCATATCTTGAAGATAAAGTCTACCTTACAGGGTATAACTTTACATTAGCAGATATACTATTGTACTATGGACTT CATCGCTTTATAGTTGACCTGACAGTTCAAGAAAAGGAGAAATATCTTAATGTGTCTCGCTGGTTTTGTCACATTCAGCATTATCCAGGC ATCAGGCAACATCTGTCTAGTGTTGTCTTCATCAAGAACAGACTATATACTAATTCCCACTAGAAGCTGTCCATGCCATACAGAAGATCT ATTAAAAATGTTTTAAATGGAAAATGTACTCTAGACCACAGGACTAATGTAAATTAATATACAGTCATTCATTATTTGTTGAAGTTGATA GAATTTTTGAAGTGTAAACTTGTGTCTGAATGTTTTATTTGTTCTTTAGCTGAAGTTTTGCAATTTTTATGTCAAAATTCAATTGCTATT AAACAAGTTGAGATCCAGTTATAAATTAACCTTGTTTTTAGTAGATGACATTTATTTCAATAAAAGTTGCAAATCGGGCTTAATCTTAAA ATTGGTGGTCATTTCAATGGTTGACATATTTGGCTATTTATTAACCTCTCTTTCATATTCTAAAATTCATTTTCCCCTTATGGATATTTA TGGTAGTTTGTTAAGAACTGATAAATTGTGCCAAGGAAGCCAAAAGGGAAGACAGATGGATTTGTTTTAAAATATTTATGTGAGCTAGTA >In-frame_ENST00000380815_ENST00000379715_TCGA-A6-6654-01A_GMDS_chr6_2116005_-_EEF1E1_chr6_8097700_length(amino acids)=336AA_start in transcript=42_stop in transcript=1052 MARRARLGRLGPPPALPARPPVRPCQTVAAGRAVRSPSLPAAWRGASCCTPPRSCRHRACPLPRSALPPTARPPRDMAHAPARCPSARGS GDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTE IYNLGAQSHVKIPVLQTNNGPSLTGLTTIAAHLVKQANKEYLLGSTAEEKAIVQQWLEYRVTQVDGHSSKNDIHTLLKDLNSYLEDKVYL -------------------------------------------------------------- >In-frame_ENST00000380815_ENST00000507463_TCGA-A6-6654-01A_GMDS_chr6_2116005_-_EEF1E1_chr6_8097700_length(transcript)=1144nt_BP=615nt GACGCGAATGACGCTGCGCCAGTCAGGCCGCAGCCCCGCTGCTTGGCCCGTCGGGCCCGCCTTGGCCGGCTCGGCCCGCCCCCGGCCCTC CCTGCACGGCCTCCCGTGCGCCCCTGTCAGACTGTGGCGGCCGGTCGCGCGGTGCGCTCTCCCTCCCTGCCCGCAGCCTGGAGAGGCGCT TCGTGCTGCACACCCCCGCGTTCCTGCCGGCACCGCGCCTGCCCTCTGCCGCGCTCCGCCCTGCCGCCGACCGCACGCCCGCCGCGGGAC ATGGCACACGCACCGGCACGCTGCCCCAGCGCCCGGGGCTCCGGGGACGGCGAGATGGGCAAGCCCAGGAACGTGGCGCTCATCACCGGT ATCACAGGCCAGGATGGTTCCTACCTGGCTGAGTTCCTGCTGGAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTT AATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCTCACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGT ACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAGATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTCCAGTTCTTCAG ACAAACAATGGTCCAAGTCTAACAGGATTGACTACTATAGCAGCTCATCTAGTCAAGCAAGCCAACAAAGAATATTTGCTGGGGAGTACT GCAGAAGAAAAAGCAATCGTTCAGCAGTGGTTAGAATACAGGGTCACTCAAGTAGATGGGCACTCCAGTAAAAATGACATCCACACACTG TTGAAGGATCTTAATTCATATCTTGAAGATAAAGTCTACCTTACAGGGTATAACTTTACATTAGCAGATATACTATTGTACTATGGACTT CATCGCTTTATAGTGAGTATTTGTATAGTTACTGGCTTTTTTTCTGTAGTGTTGAGAATGATTTTTAAAACTTTGTCTTGAATTTAAATC AGATTTGCATTTTTGGCTTATCAAATAAAAATGAAAGGAATTCCTTTATACAAGGTGCCTTTTGTAACAAACCTGCACGTTGTGCACATG >In-frame_ENST00000380815_ENST00000507463_TCGA-A6-6654-01A_GMDS_chr6_2116005_-_EEF1E1_chr6_8097700_length(amino acids)=312AA_start in transcript=42_stop in transcript=980 MARRARLGRLGPPPALPARPPVRPCQTVAAGRAVRSPSLPAAWRGASCCTPPRSCRHRACPLPRSALPPTARPPRDMAHAPARCPSARGS GDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTE IYNLGAQSHVKIPVLQTNNGPSLTGLTTIAAHLVKQANKEYLLGSTAEEKAIVQQWLEYRVTQVDGHSSKNDIHTLLKDLNSYLEDKVYL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for GMDS-EEF1E1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for GMDS-EEF1E1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for GMDS-EEF1E1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |