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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:GMDS-KIF6 (FusionGDB2 ID:33341) |
Fusion Gene Summary for GMDS-KIF6 |
Fusion gene summary |
Fusion gene information | Fusion gene name: GMDS-KIF6 | Fusion gene ID: 33341 | Hgene | Tgene | Gene symbol | GMDS | KIF6 | Gene ID | 2762 | 221458 |
Gene name | GDP-mannose 4,6-dehydratase | kinesin family member 6 | |
Synonyms | GMD|SDR3E1 | C6orf102|dJ1043E3.1|dJ137F1.4|dJ188D3.1 | |
Cytomap | 6p25.3 | 6p21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | GDP-mannose 4,6 dehydrataseGDP-D-mannose dehydrataseshort chain dehydrogenase/reductase family 3E, member 1 | kinesin-like protein KIF6 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | Q6ZMV9 | |
Ensembl transtripts involved in fusion gene | ENST00000530927, ENST00000380815, ENST00000467288, | ENST00000287152, ENST00000394362, ENST00000373213, ENST00000373216, ENST00000229913, ENST00000373215, ENST00000538893, ENST00000541946, ENST00000465719, | |
Fusion gene scores | * DoF score | 28 X 19 X 15=7980 | 13 X 10 X 10=1300 |
# samples | 32 | 15 | |
** MAII score | log2(32/7980*10)=-4.64024493622235 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/1300*10)=-3.11547721741994 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GMDS [Title/Abstract] AND KIF6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | GMDS(2245555)-KIF6(39688587), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GMDS | GO:0019673 | GDP-mannose metabolic process | 9525924 |
Hgene | GMDS | GO:0042351 | 'de novo' GDP-L-fucose biosynthetic process | 9525924 |
Fusion gene breakpoints across GMDS (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across KIF6 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | CESC | TCGA-DG-A2KL-01A | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
ChimerDB4 | CESC | TCGA-DG-A2KL-01A | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
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Fusion Gene ORF analysis for GMDS-KIF6 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000530927 | ENST00000287152 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
intron-intron | ENST00000530927 | ENST00000394362 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
intron-intron | ENST00000530927 | ENST00000373213 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
intron-intron | ENST00000530927 | ENST00000373216 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
intron-intron | ENST00000530927 | ENST00000229913 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
intron-intron | ENST00000530927 | ENST00000373215 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
intron-intron | ENST00000530927 | ENST00000538893 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
intron-intron | ENST00000530927 | ENST00000541946 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
intron-intron | ENST00000530927 | ENST00000465719 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
In-frame | ENST00000380815 | ENST00000287152 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
5CDS-intron | ENST00000380815 | ENST00000394362 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
5CDS-intron | ENST00000380815 | ENST00000373213 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
5CDS-intron | ENST00000380815 | ENST00000373216 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
5CDS-intron | ENST00000380815 | ENST00000229913 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
5CDS-intron | ENST00000380815 | ENST00000373215 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
5CDS-intron | ENST00000380815 | ENST00000538893 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
5CDS-intron | ENST00000380815 | ENST00000541946 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
5CDS-intron | ENST00000380815 | ENST00000465719 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
intron-3CDS | ENST00000467288 | ENST00000287152 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
intron-intron | ENST00000467288 | ENST00000394362 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
intron-intron | ENST00000467288 | ENST00000373213 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
intron-intron | ENST00000467288 | ENST00000373216 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
intron-intron | ENST00000467288 | ENST00000229913 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
intron-intron | ENST00000467288 | ENST00000373215 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
intron-intron | ENST00000467288 | ENST00000538893 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
intron-intron | ENST00000467288 | ENST00000541946 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
intron-intron | ENST00000467288 | ENST00000465719 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000380815 | GMDS | chr6 | 2245555 | - | ENST00000287152 | KIF6 | chr6 | 39688587 | - | 9293 | 372 | 42 | 2750 | 902 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000380815 | ENST00000287152 | GMDS | chr6 | 2245555 | - | KIF6 | chr6 | 39688587 | - | 0.002141598 | 0.99785835 |
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Fusion Genomic Features for GMDS-KIF6 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for GMDS-KIF6 |
Go to FGviewer for the breakpoints of chr6:2245555-chr6:39688587 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | KIF6 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | GMDS | chr6:2245555 | chr6:39688587 | ENST00000380815 | - | 1 | 11 | 30_35 | 34.0 | 373.0 | Nucleotide binding | NADP |
Tgene | KIF6 | chr6:2245555 | chr6:39688587 | ENST00000229913 | 0 | 10 | 356_385 | 0 | 266.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | KIF6 | chr6:2245555 | chr6:39688587 | ENST00000229913 | 0 | 10 | 456_494 | 0 | 266.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | KIF6 | chr6:2245555 | chr6:39688587 | ENST00000229913 | 0 | 10 | 588_683 | 0 | 266.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | KIF6 | chr6:2245555 | chr6:39688587 | ENST00000287152 | 0 | 23 | 356_385 | 22.0 | 815.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | KIF6 | chr6:2245555 | chr6:39688587 | ENST00000287152 | 0 | 23 | 456_494 | 22.0 | 815.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | KIF6 | chr6:2245555 | chr6:39688587 | ENST00000287152 | 0 | 23 | 588_683 | 22.0 | 815.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | KIF6 | chr6:2245555 | chr6:39688587 | ENST00000373216 | 0 | 22 | 356_385 | 22.0 | 798.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | KIF6 | chr6:2245555 | chr6:39688587 | ENST00000373216 | 0 | 22 | 456_494 | 22.0 | 798.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | KIF6 | chr6:2245555 | chr6:39688587 | ENST00000373216 | 0 | 22 | 588_683 | 22.0 | 798.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | KIF6 | chr6:2245555 | chr6:39688587 | ENST00000229913 | 0 | 10 | 5_345 | 0 | 266.0 | Domain | Kinesin motor | |
Tgene | KIF6 | chr6:2245555 | chr6:39688587 | ENST00000229913 | 0 | 10 | 97_104 | 0 | 266.0 | Nucleotide binding | ATP | |
Tgene | KIF6 | chr6:2245555 | chr6:39688587 | ENST00000287152 | 0 | 23 | 97_104 | 22.0 | 815.0 | Nucleotide binding | ATP | |
Tgene | KIF6 | chr6:2245555 | chr6:39688587 | ENST00000373216 | 0 | 22 | 97_104 | 22.0 | 798.0 | Nucleotide binding | ATP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | GMDS | chr6:2245555 | chr6:39688587 | ENST00000380815 | - | 1 | 11 | 108_112 | 34.0 | 373.0 | Nucleotide binding | NADP |
Hgene | GMDS | chr6:2245555 | chr6:39688587 | ENST00000380815 | - | 1 | 11 | 55_58 | 34.0 | 373.0 | Nucleotide binding | NADP |
Hgene | GMDS | chr6:2245555 | chr6:39688587 | ENST00000380815 | - | 1 | 11 | 86_87 | 34.0 | 373.0 | Nucleotide binding | NADP |
Hgene | GMDS | chr6:2245555 | chr6:39688587 | ENST00000530927 | - | 1 | 11 | 108_112 | 0 | 343.0 | Nucleotide binding | NADP |
Hgene | GMDS | chr6:2245555 | chr6:39688587 | ENST00000530927 | - | 1 | 11 | 30_35 | 0 | 343.0 | Nucleotide binding | NADP |
Hgene | GMDS | chr6:2245555 | chr6:39688587 | ENST00000530927 | - | 1 | 11 | 55_58 | 0 | 343.0 | Nucleotide binding | NADP |
Hgene | GMDS | chr6:2245555 | chr6:39688587 | ENST00000530927 | - | 1 | 11 | 86_87 | 0 | 343.0 | Nucleotide binding | NADP |
Tgene | KIF6 | chr6:2245555 | chr6:39688587 | ENST00000287152 | 0 | 23 | 5_345 | 22.0 | 815.0 | Domain | Kinesin motor | |
Tgene | KIF6 | chr6:2245555 | chr6:39688587 | ENST00000373216 | 0 | 22 | 5_345 | 22.0 | 798.0 | Domain | Kinesin motor |
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Fusion Gene Sequence for GMDS-KIF6 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000380815_ENST00000287152_TCGA-DG-A2KL-01A_GMDS_chr6_2245555_-_KIF6_chr6_39688587_length(transcript)=9293nt_BP=372nt GACGCGAATGACGCTGCGCCAGTCAGGCCGCAGCCCCGCTGCTTGGCCCGTCGGGCCCGCCTTGGCCGGCTCGGCCCGCCCCCGGCCCTC CCTGCACGGCCTCCCGTGCGCCCCTGTCAGACTGTGGCGGCCGGTCGCGCGGTGCGCTCTCCCTCCCTGCCCGCAGCCTGGAGAGGCGCT TCGTGCTGCACACCCCCGCGTTCCTGCCGGCACCGCGCCTGCCCTCTGCCGCGCTCCGCCCTGCCGCCGACCGCACGCCCGCCGCGGGAC ATGGCACACGCACCGGCACGCTGCCCCAGCGCCCGGGGCTCCGGGGACGGCGAGATGGGCAAGCCCAGGAACGTGGCGCTCATCACCGGT ATCACAGGCCAGATTTATTCCATAGATGAAGATGAAAAATTAATACCTAGCTTGGAAATCATCTTACCACGTGATTTGGCAGATGGGTTT GTGAATAATAAGCGAGAAAGCTACAAATTTAAATTTCAAAGAATTTTTGATCAGGATGCAAACCAAGAGACCGTTTTTGAAAACATTGCC AAACCAGTTGCTGGGAGTGTCCTGGCAGGTTACAATGGTACCATCTTTGCATATGGGCAAACAGGCAGCGGGAAGACATTCACTATCACA GGGGGTGCAGAGCGTTACAGTGACAGAGGCATTATCCCAAGGACACTGTCATACATTTTTGAACAGTTACAAAAGGACAGCAGCAAAATA TATACAACACACATTTCCTATTTGGAAATCTACAATGAATGTGGTTATGATCTTTTGGATCCAAGACATGAAGCCTCCAGTTTGGAAGAT TTGCCGAAAGTGACAATACTGGAGGATCCTGATCAGAACATTCACCTGAAAAACTTGACTCTCCATCAGGCAACCACAGAGGAAGAAGCT CTGAATTTGCTTTTTTTAGGAGACACCAACCGAATGATTGCAGAGACTCCTATGAACCAAGCTTCAACCCGTTCCCACTGCATTTTCACC ATTCATTTGTCAAGCAAGGAACCAGGATCTGCAACTGTACGACATGCCAAACTCCATCTGGTTGACCTGGCTGGTTCAGAGCGAGTTGCA AAGACTGGAGTAGGGGGCCATCTTCTAACAGAGGCCAAGTATATCAACTTGTCACTACATTACTTAGAACAGGTTATCATTGCCCTTTCA GAAAAGCACCGTTCGCACATTCCTTATAGAAACTCCATGATGACCAGTGTCCTAAGAGACAGTTTGGGAGGGAACTGCATGACAACTATG ATTGCAACACTCTCCTTGGAGAAAAGGAATCTTGATGAGTCTATATCAACCTGCAGATTTGCACAGCGAGTGGCACTCATAAAGAATGAA GCTGTTCTTAATGAAGAAATTAACCCCAGATTAGTGATTAAACGCCTACAAAAGGAAATCCAGGAACTGAAGGATGAACTGGCCATGGTC ACTGGGGAGCAGAGGACAGAGGCACTCACAGAAGCAGAGCTCCTTCAGCTGGAAAAACTAATAACATCCTTTTTGGAAGACCAGGATTCA GACAGTAGATTAGAGGTTGGCGCGGATATGCGTAAAGTTCATCACTGTTTTCATCATTTAAAGAAACTATTGAATGACAAGAAGATCCTT GAAAACAATACAGTCTCCTCTGAAAGCAAAGACCAAGATTGTCAAGAACCATTAAAAGAAGAAGAATATAGAAAGCTACGAGATATTCTG AAACAGAGAGATAACGAAATCAATATCCTGGTCAACATGTTAAAAAAAGAAAAGAAGAAAGCTCAGGAGGCTCTCCACTTGGCTGGCATG GATAGACGTGAATTCAGACAGTCCCAGAGCCCACCCTTCCGCCTAGGAAACCCAGAAGAAGGTCAAAGAATGCGACTATCCTCAGCTCCC TCACAGGCCCAGGACTTCAGCATTTTGGGGAAAAGATCCAGTTTGCTCCACAAGAAAATAGGAATGAGAGAGGAAATGTCATTAGGATGC CAGGAGGCTTTTGAAATCTTCAAGAGGGACCACGCTGACAGCGTTACCATCGATGACAACAAACAGATTCTGAAACAGAGATTTTCTGAA GCCAAGGCCCTGGGAGAAAGTATAAATGAAGCAAGAAGTAAAATTGGTCACCTGAAGGAAGAAATCACCCAGCGGCATATACAGCAAGTA GCCCTAGGAATCTCGGAAAACATGGCCGTGCCTCTGATGCCAGACCAGCAGGAGGAGAAGCTGCGATCACAACTGGAGGAAGAAAAGAGA AGGTATAAAACAATGTTCACTCGCCTGAAAGCCCTGAAGGTGGAGATCGAGCACTTGCAGCTGCTCATGGACAAAGCCAAGGTGAAGCTA CAGAAAGAGTTTGAAGTCTGGTGGGCAGAGGAGGCCACCAACCTGCAGGTAAATTCTCCAGCAGTGAATTCACTCGATCACACGAAGCCA TTTCTCCAGACATCTGACTCCCAGCATGAATGGTCCCAACTCCTCTCTAACAAAAGTTCTGGAGGCTGGGAAGTCCAAGATCAAGGCACT GGCAGATTCGATGTCTGTGATGTGAATGCCAGGAAAATCCTGCCCTCGCCTTGCCCCAGTCCACACAGCCAGAAACAGAGCAGCACCAGC ACCCCACTGGAAGACAGCATCCCCAAGAGGCCAGTGTCGTCCATCCCTCTCACCGGAGACAGCCAGACGGACTCGGACATCATCGCCTTC ATCAAGGCCAGACAGAGCATTCTGCAGAAGCAATGTTTGGGAAGCAATTGAATTTCCAGGAAATATCCATCCATGAATTATGCCAGCAAG AATGAAGCACAGATGAAGGCAGCGCCCCTCACTTGCTCTGGCTTCAGAAGTGAACTATGGGCTGCTGGGAGCAACTAGTGACTTTGATTC CCATGGAGGGGACTGTGTTTCTTTAAGGATGCTGACCTGGAGGCCACCGAGAGGCTGGGGCTGGGGCTGACCACAACATCCTTCCTGTGG TTGCTGGAGCTGCTGGCAGGGCCAGGCAAGGCCAGAGTGCTAGGGGCAGGGTGAAGGCTTCAGCTCACTGTTGTAGTGACGTTTTGTGTA GATCTTTATAAGCTTTTGAGAATGTGAAATAGCACCATCAAAATATAATGTCAGAGGATGCTCACACCAGTGGAATGTGGGGGGAATATT TTTATTTTTAACGATTTGCCAGCTCTCTCCCTTGGCCCGTGCTCTGGTTTGGAAGCCCAGAAATGGCCATGACAGGTCCAGGCAGGATGT CCCAGCCACAGGCAAGGCAGTGGAATGCAGGGCATCCTGAAGGCCAATCCTGATCTCCCAGACCACATCTTTCACCATCAGCCTCTTGGC CAGGATGACCTGGAGGCAGTGCCTGAACAGCTGTGTCTCCAGGGAGCCATCTGCCCTGCAGGGTCTAAGGACATCATAGCACCCAGAGAA CAGTGGGCAGCTCCCAGGGGCTCTGCTGAGAGCTTGAGAGAGGGCAGTGTGGGTACCTTGGGCCTCACAACCTTCACCCAGCCACTTGGG AGGATTTGGGCTGACACTCCCCACTTCCACAGGGAAAAACATAGCTGCCTGGGGGTCTTGTCTCCATGGGCCCTCTCCATGACAGATCCA AGGGAAGGTGGGCAGCCCTCAAGGAGGTTCTTGAAGAACTGCCCCCTGGGCCAGGGGGTTCCAACCCAGCTGCAGCCAGGGAGGGGCAGC GGAGGGTGAGCAGGAGTGGCACCTGGAAATGAAGCTAACTGGATAAAAGTGCTGGTCCACTGCTCCTGGTGTCTCTGTCCTATAAATACA GGACCTGATGACCCTGGAGGGGAGCAGAGTGGTAATATAGTATAATTGGCTTGATTTTCTTTTTCGTTTTTTAGGACTGGGTAACAGGAT CATGCAGGAGAAGATTAAACCATTACATTTCTAAGCTAGGCAGGCCCATCGAGCTCCTCTAATCCACACCCCTATTTTATATAATTAGAA GGCCAGAGTGAAGGGGAGATTCAGCTTGCTGTTCTATGCCACTGACAAATGTCCCCTCTTCAGGGGGCTTCCCCTGACCACTCCATCTCG AGTCACCCCCTAGTTATCCCCTATCCCATTACCATTTTTTCTGCATCACTATCTGACATGTTATCCTTCCGAACTTGCCTATTTTTGAAA TACCTGCAACCCCCCATAATACTAAGAGCTCCAATGCAACAGGGACCTGTTTGTCTTGCTCATTGCTGTGTCCCAAGCACAGAGTCGCTG TTCAGTAAACGGTCCTTCAGTTCATGAGTAGACGAGCCAGAACCCAGATGTGTTTCTCAGGCTGGTGTCACTCTGACTTCCCCCAGGCTC TGACTGAATCCCATCGGGACAGGGGCCAGCATCTCTGGTCCACTCCTGGCCCTCACAGTTCAATGGAACATAGTAAGCCCTCTGTAAAGT CTGTAGAACCAGAGGAAGACCAAATTCTGATTCTAGAAGCCTCCCCAAGAGTCCATGGAACACACATGTAACTGCACACACACACACACA TACACACACACACTCTCAAGAGCCCTGAAGATGGCATGGCATTTGCCCCAGTCCCCTATGTAGCAGCAGCAGTATTCTTGGCATGCCTTA GTGCCCTCAGCCCTCTAGAGCTGGGTAGAGTCTACTAACTTTTATTTTCTTTTATTTTTACTTTCTTTTATTTATTTTTTGAGATGGGGG GGGTCTCTGTCAGCCAGGCTGGGGTGCAGTGGTGCGACCATACCTCACTAGTCAGCCTCCAACTCCTGGGCTCAAGCCATACTCAGCCTC CAACTCCTGGGCTCAAGCGATCCTCTCACCTCAGCCTCCAAAGTAGCTGGAACTACAGGCATGCACCACCACACCTAGCTCGTTTTAAAT TTTTTGTAGAGACAGGGTCTCACTGTGTGGCTCAGGATGGTCTCAAATTCCTGGCCTTAAGCGATGCTCCCGCCTTGGCCTCCCAAAGTG CTGGGATTGCAGGCATGAGCCACATACCCTGCCAGAGTCTTTCAACATTAGATCTCCCACTGAGACATCATCTCCTGGATCCAAAGGCCT TACTGACAGAGATGTGTGGCATGGCCCCATGCGGGGTGTGAACCAGCCTCCTGGGGCAATCACTAAGACAGGAAAGGAAATGAAGACAGA AAAACACACAACATGGGATCTGGGGCCACTGGTGTCCAGAGCATATGCAAAGTGTGTGCAGCAACTGGCCAAGGGGCCTTTTGCTCCGAA CATCCCCTAATGGAAGCCCAGCCTTTGATATGGACACATGCTTGACAGCAGTGCACCTTCCCAGAGTTCACTGGCCTCTGCAAATGGGAG AAATTGATGCAATGTTTTGAAAAGACTTTCCAGCAATCCACCTGGGATCAGTGGAGCCACGGATGACAAGAAGTATCTGAGTTCACTCTA GGCCAAAATGTGGGATTTTCAAAAACATTTTCTGGAAAGCAGCCTAGCCAGTGACTCCAGCCCAGTCCCTGCTAGAATTCAACTGGCTCT ACCAATCCCTTGACAAGAAGTAGGGTGGACGGAGGTTGGAGGAGGGAAGTTAAAATGTAGCTTGCCCAGATCTTGCTAAAAAGGAGTTTT AGAAAGCAGATAGAGAAATTGTGGTATACTGAATACATCATTTTAATTCTTCACCACCAGTATAGAATTACACATCCAAAGCTTTGTCAT GGCCCACTTTGACTAATGTGGTGTTGGCAAACCTGATCCAGGCAGAGGCTTGAATTGTGCTCTCATGGTTGAGCTTGCCTCTTGCTCCAG TGATCTCTCTTGGGATGAACATGCCATGGGTAGCTGCTGCCCCTTCAGCCTGGAACATCCAGAGAGCAGACCTGAGCCCAGTCTACAGCC TGGAGCAGAGCCTCCCAGGCAAGCCCAGCCCAGATCAGCTGAACTATGGCTCACCCAAAGACCTATTGGCATGAGAATATATGCTGCTTG TCATAAACCACTGAGGTTTAGAGTGGTTTGTTATATAGCATTAATTGTAGCAATAGCAGACTGGCACAGAAATTGGAACCCAGAGACAGT ATATGACTGGATCTAGGATTTCTCAGTGCAGAGTTCATTGTCTCTCCATGCAGCCTGTGGAAAGGCACTGAGAGCATCCTGTATATGGAA AAGCAGGACCACCACCTACAGCCATGATGAAGCAACAAGGACCTGATTTACCCTCCTGCTTTAAATGACTAAAAATGAGACAAAATCCTC TATACAAACCAATGGTTTTCAGCCATTGGATAACAAGCAATATAGGGTATGATTGATCCGCAAGAGAAGGGAAACAAGTGAGGGGAGCCC TATGATTGCTCCAACTTACTGCCTGCAGTGAGTTTTCAGGCTGCAGCCCAGGAAGGGGGAACCAGGTAGAGCCCAGTGGTTTCCCTGAGT TGAGGAAATGGAGCTGGGAATCCAGGGAGGACAAAGTGGCTTAAATTTGCAAGGCAGAGTCCCAGGGATGAGAGAGAGAGAAGGAGAGAG AGAGGAGAAAAAAGAGAGAGAAAGAGAGAGAGCATGCTCTGGAGATCTTCAGAGGGTTACCCTTGAGTCTTCAGCTAACTACCGATCAAC ATCTGCATGTGAAGAAATTACCCAAGGCAGGGGAAAGAACCACCAGGAGGAAGCAGGTGGAATAATTTCCTGAGATAACACTGTGTTGGG AAGAGTTCATGTTTCCAACAGCCAGAGTGGAGAAACCTCCCAAAACAGTCATTGTATAGAGACACATAAGGTACTGCCTCAGAAGTGGGG CCAAATTAGTCCTAGATGATAGATTGCTCTGGTCCCACCTAACAAAGCTTAAAAAGCCAGCCCCAAAGGAGTCAAATTGTTTCCAGTAAG TTTCCAAGTAACTTCAATGAGTCCCAAAACAAAGCTTCAAAATATCTAAAGGAATATGAAAAACAAACCAAAAAGAAACCAGCATCCAAC AATATAGAATCCACAATGTCTGGTGTCCATTAAAAAATAATCAGGCATGCAAAGAAGCAGGAAAATATGGGCCATGAGAGGAGAAAAAAC CATCAATAGAAATAGAGGCCGGGTGTGGTGGCTCACTCCTATAATCCCAGCACTTTGGGAGGCCGAGGCAGGAGGATCACCTGAGGTCAG GAGTTCAAGAACAGCCTGTTCAACATGGGGAAACCCCGTCTCTACTAAAAATACAAAAAATAGCCGGGCATGGTGTTGCGTACCTGTAAT CCCAGCTACTCAGAGGCTGAGGCAGGAGAATTGCTTGAGCCCAGGAGGCAGAGGTTACAGTGAGCCGAAATTGTGCCATTGCACTCCAGC TTGGGCAACAAGAGTGAAACTCTGTCTCAAAAAAAAAAAAAAGAAAAAACAAATAGAAACAGCCCCAGGCATGGCACAGTTGATAGAGTA AATAGACAGAAACATTTTTTAAAATGCAATGGGTGTGTGTTTCAAATCTAGGCAGAAAAAATGCTCCTTGTAATTCCTTAAACATAAGCA TGTCTCATTCATCTGGTCATTGTTTTGACAAGGATGTGCCATCCATTGTGCTAAGTTCTGAGGAGTCAGAGGTGACAGAGACAGAGAAAG TGCCAGCATTCTTGGAACCTTCTAACGAAGGAGAGGGACAAGCCAGGCATGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGACTGA GGCTGGCGGATCACGAGGTCAGGAGTTTGAGACCAACCTGGCCAACATGGCGAAACCCCATCGCTACTAAAAATACAAAAATTAGCTGGG TGTGGTGGTGCGCACCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGACAATCACTTGAACCCTGGAGGCAGAGTTTGCAGTGAGCTG AGATCGTGCCACTGCACTCCAACCTGGGCAACAAGAGCGAGACTCCTTCTCTGAAAAAAAAAAAAAGAGAGGGACAATAAACAAGTAAGC AAGACAATCTGATTAAGAAGGAGTTGGGGTTAGCTGGGCATGGTAGCAAGCGCCTGTAGTCTCAGCTACTCGGGAGGCTGAGGTGGGAGG ATCCTTGAACCCAGGAGGTTAAGGCTGCAGTGAGCTGTGATCACACCACTGCACTCCAGCCTGGATGACAGAGCAAGACCCTGTCTCAGA AAAAGAAGAAGGAGTTGGGGGTGGGGTAGGATGGGCTTGGACTCACTATCAAGGTGGGTGGGAGTGTGAGAACCCGGCAAGGTGCAAAGA GAGAAGCAGGGAAGGGAAGCTTAGGACAATGATGGCAGGTTGGGTATTGGGTGATGGGAAGAGGCAAAGGACGTGGAGCTTGGCAAAAAG GGGACTTGTGGGGATTTGGGCCATGTGAGCATGTGGGGGAGACAGTGTTCCTTCCATAACACGTGTCCAGGGACTGCCAGGGCTCCGAGG CAGAGCAGGTGTAGAGAGGTTGGCTGTGAATGTTGGATGTTGAAAACATATGTGTCAAATGTGGGAGGAAAAAGCAGTGTTTCCTTGAAT ACAAGCTCCTCCTCACCTTGCGAAAAGTGGCCTCTGAGTGTAGCCCTGAATGCATCTCCCAAGGAATAGGAGGAAGCAGCAACCTTTTCA GAGTTAACTGCTTTATTTGGGTTTTCCATGGCCTCGTGCCAGCCAGCAGGGCTGAGCCAGTTTCACCCACACTGAGAGGGAACTCAGCAA AGAGCAAGCAGCATGCCAGCTGGTACTCTTCCCTCTCCATTCACTCAGCTCCTGATCTCAGGAGGGCAGCCCCTCCCCAGGCCAGCACCC CTCCCCTTCTGGCCCCAGGTGTGGGATGTTGTTGTTTTCTTTTCTCCGAAACATCTCCTGGGTTTGTCTTTTCCATCACTGTCTTTAGAC TGAGGCAAGCAGTCCCCATGCCTTCAGCCCCATGTTTTGGGGGTAACCTGTGCTTTGACATGCTTTGCTAAAAACTTTCTAAGTCTCCCT CTGGTGCTGGGACCAGCCATGACCAACAACGTCATCCATGCAGGCCACCCCTAACATAGTCCAGGCCTCATGTGGGTCTCAGTTCCCTTT TCTTCTTTCAGGAAGTTCTCCAGTGCATGCATAGGGTTGACCAGATGTCCCAAGGTGCTCTAGGACTTATGCCTATGAAGCTGTTTTAGG GCTTCCTAGTCAGTCCCTGGTTCCAGGAAAGCAGCCTGATGAGGAGATCATTCCCGCTGGCTGGTGTGGCATTTCTTTTATGGCACTACC TGGGATTGGGCCACCAGACCTGCGCTAACATGCTGATTTGATGGACTCTTAACATCATAGGACAAAGAATCGTCATGTGAACCAATTAGA >In-frame_ENST00000380815_ENST00000287152_TCGA-DG-A2KL-01A_GMDS_chr6_2245555_-_KIF6_chr6_39688587_length(amino acids)=902AA_start in transcript=42_stop in transcript=2750 MARRARLGRLGPPPALPARPPVRPCQTVAAGRAVRSPSLPAAWRGASCCTPPRSCRHRACPLPRSALPPTARPPRDMAHAPARCPSARGS GDGEMGKPRNVALITGITGQIYSIDEDEKLIPSLEIILPRDLADGFVNNKRESYKFKFQRIFDQDANQETVFENIAKPVAGSVLAGYNGT IFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQLQKDSSKIYTTHISYLEIYNECGYDLLDPRHEASSLEDLPKVTILEDPDQNI HLKNLTLHQATTEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTIHLSSKEPGSATVRHAKLHLVDLAGSERVAKTGVGGHLLTEAKY INLSLHYLEQVIIALSEKHRSHIPYRNSMMTSVLRDSLGGNCMTTMIATLSLEKRNLDESISTCRFAQRVALIKNEAVLNEEINPRLVIK RLQKEIQELKDELAMVTGEQRTEALTEAELLQLEKLITSFLEDQDSDSRLEVGADMRKVHHCFHHLKKLLNDKKILENNTVSSESKDQDC QEPLKEEEYRKLRDILKQRDNEINILVNMLKKEKKKAQEALHLAGMDRREFRQSQSPPFRLGNPEEGQRMRLSSAPSQAQDFSILGKRSS LLHKKIGMREEMSLGCQEAFEIFKRDHADSVTIDDNKQILKQRFSEAKALGESINEARSKIGHLKEEITQRHIQQVALGISENMAVPLMP DQQEEKLRSQLEEEKRRYKTMFTRLKALKVEIEHLQLLMDKAKVKLQKEFEVWWAEEATNLQVNSPAVNSLDHTKPFLQTSDSQHEWSQL LSNKSSGGWEVQDQGTGRFDVCDVNARKILPSPCPSPHSQKQSSTSTPLEDSIPKRPVSSIPLTGDSQTDSDIIAFIKARQSILQKQCLG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for GMDS-KIF6 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for GMDS-KIF6 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for GMDS-KIF6 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | KIF6 | C0027051 | Myocardial Infarction | 1 | CTD_human |