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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GMPR2-TSSK4 (FusionGDB2 ID:33393)

Fusion Gene Summary for GMPR2-TSSK4

check button Fusion gene summary
Fusion gene informationFusion gene name: GMPR2-TSSK4
Fusion gene ID: 33393
HgeneTgene
Gene symbol

GMPR2

TSSK4

Gene ID

51292

283629

Gene nameguanosine monophosphate reductase 2testis specific serine kinase 4
SynonymsGMPR 2C14orf20|STK22E|TSK-4|TSK4|TSSK5
Cytomap

14q12

14q12

Type of geneprotein-codingprotein-coding
DescriptionGMP reductase 2guanosine 5'-monophosphate oxidoreductase 2guanosine monophosphate reductase isologtestis-specific serine/threonine-protein kinase 4serine/threonine kinase 22Eserine/threonine-protein kinase 22E
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000355299, ENST00000559836, 
ENST00000559910, ENST00000399440, 
ENST00000420554, ENST00000348719, 
ENST00000557854, ENST00000559104, 
ENST00000456667, ENST00000560517, 
ENST00000339917, ENST00000556621, 
ENST00000287913, ENST00000428351, 
Fusion gene scores* DoF score4 X 4 X 4=642 X 1 X 2=4
# samples 42
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: GMPR2 [Title/Abstract] AND TSSK4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGMPR2(24702799)-TSSK4(24677170), # samples:1
Anticipated loss of major functional domain due to fusion event.GMPR2-TSSK4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GMPR2-TSSK4 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
GMPR2-TSSK4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGMPR2

GO:0046037

GMP metabolic process

22037469

TgeneTSSK4

GO:0006468

protein phosphorylation

15964553

TgeneTSSK4

GO:0032793

positive regulation of CREB transcription factor activity

15964553


check buttonFusion gene breakpoints across GMPR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TSSK4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0887-01AGMPR2chr14

24702799

+TSSK4chr14

24677170

+


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Fusion Gene ORF analysis for GMPR2-TSSK4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000355299ENST00000339917GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000355299ENST00000556621GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000355299ENST00000287913GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000355299ENST00000428351GMPR2chr14

24702799

+TSSK4chr14

24677170

+
Frame-shiftENST00000559836ENST00000339917GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000559836ENST00000556621GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000559836ENST00000287913GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000559836ENST00000428351GMPR2chr14

24702799

+TSSK4chr14

24677170

+
Frame-shiftENST00000559910ENST00000339917GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000559910ENST00000556621GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000559910ENST00000287913GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000559910ENST00000428351GMPR2chr14

24702799

+TSSK4chr14

24677170

+
Frame-shiftENST00000399440ENST00000339917GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000399440ENST00000556621GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000399440ENST00000287913GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000399440ENST00000428351GMPR2chr14

24702799

+TSSK4chr14

24677170

+
Frame-shiftENST00000420554ENST00000339917GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000420554ENST00000556621GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000420554ENST00000287913GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000420554ENST00000428351GMPR2chr14

24702799

+TSSK4chr14

24677170

+
Frame-shiftENST00000348719ENST00000339917GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000348719ENST00000556621GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000348719ENST00000287913GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000348719ENST00000428351GMPR2chr14

24702799

+TSSK4chr14

24677170

+
Frame-shiftENST00000557854ENST00000339917GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000557854ENST00000556621GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000557854ENST00000287913GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000557854ENST00000428351GMPR2chr14

24702799

+TSSK4chr14

24677170

+
Frame-shiftENST00000559104ENST00000339917GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000559104ENST00000556621GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000559104ENST00000287913GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000559104ENST00000428351GMPR2chr14

24702799

+TSSK4chr14

24677170

+
Frame-shiftENST00000456667ENST00000339917GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000456667ENST00000556621GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000456667ENST00000287913GMPR2chr14

24702799

+TSSK4chr14

24677170

+
In-frameENST00000456667ENST00000428351GMPR2chr14

24702799

+TSSK4chr14

24677170

+
intron-3CDSENST00000560517ENST00000339917GMPR2chr14

24702799

+TSSK4chr14

24677170

+
intron-3CDSENST00000560517ENST00000556621GMPR2chr14

24702799

+TSSK4chr14

24677170

+
intron-3CDSENST00000560517ENST00000287913GMPR2chr14

24702799

+TSSK4chr14

24677170

+
intron-3CDSENST00000560517ENST00000428351GMPR2chr14

24702799

+TSSK4chr14

24677170

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GMPR2-TSSK4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GMPR2chr1424702804+TSSK4chr1424677169+0.0003069430.99969304
GMPR2chr1424702804+TSSK4chr1424677169+0.0003069430.99969304

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GMPR2-TSSK4


check button Go to

FGviewer for the breakpoints of chr14:24702799-chr14:24677170

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGMPR2chr14:24702799chr14:24677170ENST00000355299+31026_2769.0349.0Nucleotide bindingNADP%3B shared with neighboring subunit
HgeneGMPR2chr14:24702799chr14:24677170ENST00000399440+31026_2769.0349.0Nucleotide bindingNADP%3B shared with neighboring subunit
HgeneGMPR2chr14:24702799chr14:24677170ENST00000420554+2926_2787.0367.0Nucleotide bindingNADP%3B shared with neighboring subunit
HgeneGMPR2chr14:24702799chr14:24677170ENST00000559836+31026_2769.0349.0Nucleotide bindingNADP%3B shared with neighboring subunit

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGMPR2chr14:24702799chr14:24677170ENST00000355299+310129_13169.0349.0Nucleotide bindingNADP
HgeneGMPR2chr14:24702799chr14:24677170ENST00000355299+310180_18169.0349.0Nucleotide bindingNADP
HgeneGMPR2chr14:24702799chr14:24677170ENST00000355299+310285_28669.0349.0Nucleotide bindingNADP
HgeneGMPR2chr14:24702799chr14:24677170ENST00000355299+310314_31769.0349.0Nucleotide bindingNADP%3B shared with neighboring subunit
HgeneGMPR2chr14:24702799chr14:24677170ENST00000399440+310129_13169.0349.0Nucleotide bindingNADP
HgeneGMPR2chr14:24702799chr14:24677170ENST00000399440+310180_18169.0349.0Nucleotide bindingNADP
HgeneGMPR2chr14:24702799chr14:24677170ENST00000399440+310285_28669.0349.0Nucleotide bindingNADP
HgeneGMPR2chr14:24702799chr14:24677170ENST00000399440+310314_31769.0349.0Nucleotide bindingNADP%3B shared with neighboring subunit
HgeneGMPR2chr14:24702799chr14:24677170ENST00000420554+29129_13187.0367.0Nucleotide bindingNADP
HgeneGMPR2chr14:24702799chr14:24677170ENST00000420554+29180_18187.0367.0Nucleotide bindingNADP
HgeneGMPR2chr14:24702799chr14:24677170ENST00000420554+29285_28687.0367.0Nucleotide bindingNADP
HgeneGMPR2chr14:24702799chr14:24677170ENST00000420554+29314_31787.0367.0Nucleotide bindingNADP%3B shared with neighboring subunit
HgeneGMPR2chr14:24702799chr14:24677170ENST00000559836+310129_13169.0349.0Nucleotide bindingNADP
HgeneGMPR2chr14:24702799chr14:24677170ENST00000559836+310180_18169.0349.0Nucleotide bindingNADP
HgeneGMPR2chr14:24702799chr14:24677170ENST00000559836+310285_28669.0349.0Nucleotide bindingNADP
HgeneGMPR2chr14:24702799chr14:24677170ENST00000559836+310314_31769.0349.0Nucleotide bindingNADP%3B shared with neighboring subunit
HgeneGMPR2chr14:24702799chr14:24677170ENST00000355299+310219_22169.0349.0RegionGMP binding
HgeneGMPR2chr14:24702799chr14:24677170ENST00000355299+310242_24369.0349.0RegionGMP binding
HgeneGMPR2chr14:24702799chr14:24677170ENST00000355299+310268_27069.0349.0RegionGMP binding
HgeneGMPR2chr14:24702799chr14:24677170ENST00000355299+310286_29069.0349.0RegionGMP binding
HgeneGMPR2chr14:24702799chr14:24677170ENST00000399440+310219_22169.0349.0RegionGMP binding
HgeneGMPR2chr14:24702799chr14:24677170ENST00000399440+310242_24369.0349.0RegionGMP binding
HgeneGMPR2chr14:24702799chr14:24677170ENST00000399440+310268_27069.0349.0RegionGMP binding
HgeneGMPR2chr14:24702799chr14:24677170ENST00000399440+310286_29069.0349.0RegionGMP binding
HgeneGMPR2chr14:24702799chr14:24677170ENST00000420554+29219_22187.0367.0RegionGMP binding
HgeneGMPR2chr14:24702799chr14:24677170ENST00000420554+29242_24387.0367.0RegionGMP binding
HgeneGMPR2chr14:24702799chr14:24677170ENST00000420554+29268_27087.0367.0RegionGMP binding
HgeneGMPR2chr14:24702799chr14:24677170ENST00000420554+29286_29087.0367.0RegionGMP binding
HgeneGMPR2chr14:24702799chr14:24677170ENST00000559836+310219_22169.0349.0RegionGMP binding
HgeneGMPR2chr14:24702799chr14:24677170ENST00000559836+310242_24369.0349.0RegionGMP binding
HgeneGMPR2chr14:24702799chr14:24677170ENST00000559836+310268_27069.0349.0RegionGMP binding
HgeneGMPR2chr14:24702799chr14:24677170ENST00000559836+310286_29069.0349.0RegionGMP binding
TgeneTSSK4chr14:24702799chr14:24677170ENST000002879132425_293268.0329.0DomainProtein kinase
TgeneTSSK4chr14:24702799chr14:24677170ENST000003399172425_293278.0339.0DomainProtein kinase
TgeneTSSK4chr14:24702799chr14:24677170ENST000005566212425_293192.0253.0DomainProtein kinase
TgeneTSSK4chr14:24702799chr14:24677170ENST000002879132431_39268.0329.0Nucleotide bindingATP
TgeneTSSK4chr14:24702799chr14:24677170ENST000003399172431_39278.0339.0Nucleotide bindingATP
TgeneTSSK4chr14:24702799chr14:24677170ENST000005566212431_39192.0253.0Nucleotide bindingATP


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Fusion Gene Sequence for GMPR2-TSSK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GMPR2-TSSK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GMPR2-TSSK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GMPR2-TSSK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGMPR2C0001418Adenocarcinoma1CTD_human
HgeneGMPR2C0024623Malignant neoplasm of stomach1CTD_human
HgeneGMPR2C0038356Stomach Neoplasms1CTD_human
HgeneGMPR2C0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneGMPR2C0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneGMPR2C0205643Carcinoma, Cribriform1CTD_human
HgeneGMPR2C0205644Carcinoma, Granular Cell1CTD_human
HgeneGMPR2C0205645Adenocarcinoma, Tubular1CTD_human
HgeneGMPR2C1708349Hereditary Diffuse Gastric Cancer1CTD_human