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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GNAS-HEG1 (FusionGDB2 ID:33507)

Fusion Gene Summary for GNAS-HEG1

check button Fusion gene summary
Fusion gene informationFusion gene name: GNAS-HEG1
Fusion gene ID: 33507
HgeneTgene
Gene symbol

GNAS

HEG1

Gene ID

2778

57493

Gene nameGNAS complex locusheart development protein with EGF like domains 1
SynonymsAHO|C20orf45|GNAS1|GPSA|GSA|GSP|NESP|PITA3|POH|SCG6|SgVIHEG|MST112|MSTP112
Cytomap

20q13.32

3q21.2

Type of geneprotein-codingprotein-coding
Descriptionprotein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha protein HEG homolog 1heart of glass
Modification date2020032920200313
UniProtAcc

P63092

Q9ULI3

Ensembl transtripts involved in fusion geneENST00000313949, ENST00000371098, 
ENST00000371075, ENST00000371100, 
ENST00000371099, ENST00000371102, 
ENST00000464624, ENST00000306120, 
ENST00000371095, ENST00000371085, 
ENST00000354359, ENST00000265620, 
ENST00000306090, ENST00000371081, 
ENST00000311127, ENST00000477536, 
Fusion gene scores* DoF score44 X 25 X 16=176004 X 4 X 3=48
# samples 514
** MAII scorelog2(51/17600*10)=-5.10893437155316
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNAS [Title/Abstract] AND HEG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGNAS(57486241)-HEG1(124692749), # samples:2
HEG1(124756747)-GNAS(57485060), # samples:1
Anticipated loss of major functional domain due to fusion event.GNAS-HEG1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
GNAS-HEG1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GNAS-HEG1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHEG1

GO:1905709

negative regulation of membrane permeability

26780829

TgeneHEG1

GO:2000299

negative regulation of Rho-dependent protein serine/threonine kinase activity

26780829


check buttonFusion gene breakpoints across GNAS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HEG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-DJ-A13S-01AGNASchr20

57486241

-HEG1chr3

124692749

-
ChimerDB4THCATCGA-H2-A2K9-01AGNASchr20

57486241

-HEG1chr3

124692749

-


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Fusion Gene ORF analysis for GNAS-HEG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000313949ENST00000311127GNASchr20

57486241

-HEG1chr3

124692749

-
5CDS-intronENST00000313949ENST00000477536GNASchr20

57486241

-HEG1chr3

124692749

-
intron-3CDSENST00000371098ENST00000311127GNASchr20

57486241

-HEG1chr3

124692749

-
intron-intronENST00000371098ENST00000477536GNASchr20

57486241

-HEG1chr3

124692749

-
In-frameENST00000371075ENST00000311127GNASchr20

57486241

-HEG1chr3

124692749

-
5CDS-intronENST00000371075ENST00000477536GNASchr20

57486241

-HEG1chr3

124692749

-
Frame-shiftENST00000371100ENST00000311127GNASchr20

57486241

-HEG1chr3

124692749

-
5CDS-intronENST00000371100ENST00000477536GNASchr20

57486241

-HEG1chr3

124692749

-
intron-3CDSENST00000371099ENST00000311127GNASchr20

57486241

-HEG1chr3

124692749

-
intron-intronENST00000371099ENST00000477536GNASchr20

57486241

-HEG1chr3

124692749

-
Frame-shiftENST00000371102ENST00000311127GNASchr20

57486241

-HEG1chr3

124692749

-
5CDS-intronENST00000371102ENST00000477536GNASchr20

57486241

-HEG1chr3

124692749

-
In-frameENST00000464624ENST00000311127GNASchr20

57486241

-HEG1chr3

124692749

-
5CDS-intronENST00000464624ENST00000477536GNASchr20

57486241

-HEG1chr3

124692749

-
intron-3CDSENST00000306120ENST00000311127GNASchr20

57486241

-HEG1chr3

124692749

-
intron-intronENST00000306120ENST00000477536GNASchr20

57486241

-HEG1chr3

124692749

-
Frame-shiftENST00000371095ENST00000311127GNASchr20

57486241

-HEG1chr3

124692749

-
5CDS-intronENST00000371095ENST00000477536GNASchr20

57486241

-HEG1chr3

124692749

-
Frame-shiftENST00000371085ENST00000311127GNASchr20

57486241

-HEG1chr3

124692749

-
5CDS-intronENST00000371085ENST00000477536GNASchr20

57486241

-HEG1chr3

124692749

-
Frame-shiftENST00000354359ENST00000311127GNASchr20

57486241

-HEG1chr3

124692749

-
5CDS-intronENST00000354359ENST00000477536GNASchr20

57486241

-HEG1chr3

124692749

-
Frame-shiftENST00000265620ENST00000311127GNASchr20

57486241

-HEG1chr3

124692749

-
5CDS-intronENST00000265620ENST00000477536GNASchr20

57486241

-HEG1chr3

124692749

-
Frame-shiftENST00000306090ENST00000311127GNASchr20

57486241

-HEG1chr3

124692749

-
5CDS-intronENST00000306090ENST00000477536GNASchr20

57486241

-HEG1chr3

124692749

-
intron-3CDSENST00000371081ENST00000311127GNASchr20

57486241

-HEG1chr3

124692749

-
intron-intronENST00000371081ENST00000477536GNASchr20

57486241

-HEG1chr3

124692749

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000313949GNASchr2057486241-ENST00000311127HEG1chr3124692749-7845257811262214362
ENST00000371075GNASchr2057486241-ENST00000311127HEG1chr3124692749-7818255110962187363
ENST00000464624GNASchr2057486241-ENST00000311127HEG1chr3124692749-9031376432156717

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000313949ENST00000311127GNASchr2057486241-HEG1chr3124692749-0.0007119180.99928814
ENST00000371075ENST00000311127GNASchr2057486241-HEG1chr3124692749-0.0006527990.99934715
ENST00000464624ENST00000311127GNASchr2057486241-HEG1chr3124692749-0.003520190.9964798

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Fusion Genomic Features for GNAS-HEG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GNAS-HEG1


check button Go to

FGviewer for the breakpoints of chr20:57486241-chr3:124692749

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNAS

P63092

HEG1

Q9ULI3

FUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161). {ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:17110384, ECO:0000269|PubMed:21488135, ECO:0000269|PubMed:26206488, ECO:0000269|PubMed:8702665}.FUNCTION: Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNASchr20:57486241chr3:124692749ENST00000371100-1313641_6671159.01038.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr3:124692749ENST00000371100-1313730_7561159.01038.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr3:124692749ENST00000371102-1212641_6671145.01024.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr3:124692749ENST00000371102-1212730_7561145.01024.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr3:124692749ENST00000313949-131378_142729.666666666666626.333333333333332Compositional biasGlu-rich
HgeneGNASchr20:57486241chr3:124692749ENST00000371075-131378_142730.666666666666636.333333333333336Compositional biasGlu-rich
HgeneGNASchr20:57486241chr3:124692749ENST00000371100-1313358_5221159.01038.0Compositional biasAla-rich
HgeneGNASchr20:57486241chr3:124692749ENST00000371102-1212358_5221145.01024.0Compositional biasAla-rich
HgeneGNASchr20:57486241chr3:124692749ENST00000265620-121239_394501.0380.0DomainG-alpha
HgeneGNASchr20:57486241chr3:124692749ENST00000306090-131339_394500.0381.0DomainG-alpha
HgeneGNASchr20:57486241chr3:124692749ENST00000354359-131339_394517.0396.0DomainG-alpha
HgeneGNASchr20:57486241chr3:124692749ENST00000371085-131339_394516.0395.0DomainG-alpha
HgeneGNASchr20:57486241chr3:124692749ENST00000371095-121239_394502.0381.0DomainG-alpha
HgeneGNASchr20:57486241chr3:124692749ENST00000371100-1313682_10371159.01038.0DomainG-alpha
HgeneGNASchr20:57486241chr3:124692749ENST00000371102-1212682_10371145.01024.0DomainG-alpha
HgeneGNASchr20:57486241chr3:124692749ENST00000265620-1212197_204501.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000265620-1212223_227501.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000265620-1212292_295501.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000265620-121247_55501.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000306090-1313197_204500.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000306090-1313223_227500.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000306090-1313292_295500.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000306090-131347_55500.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000354359-1313197_204517.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000354359-1313223_227517.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000354359-1313292_295517.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000354359-131347_55517.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371085-1313197_204516.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371085-1313223_227516.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371085-1313292_295516.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371085-131347_55516.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371095-1212197_204502.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371095-1212223_227502.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371095-1212292_295502.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371095-121247_55502.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371100-1313690_6981159.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371100-1313840_8471159.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371100-1313866_8701159.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371100-1313935_9381159.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371102-1212690_6981145.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371102-1212840_8471145.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371102-1212866_8701145.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000371102-1212935_9381145.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr3:124692749ENST00000265620-1212196_204501.0380.0RegionG2 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000265620-1212219_228501.0380.0RegionG3 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000265620-1212288_295501.0380.0RegionG4 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000265620-1212364_369501.0380.0RegionG5 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000265620-121242_55501.0380.0RegionG1 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000306090-1313196_204500.0381.0RegionG2 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000306090-1313219_228500.0381.0RegionG3 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000306090-1313288_295500.0381.0RegionG4 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000306090-1313364_369500.0381.0RegionG5 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000306090-131342_55500.0381.0RegionG1 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000354359-1313196_204517.0396.0RegionG2 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000354359-1313219_228517.0396.0RegionG3 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000354359-1313288_295517.0396.0RegionG4 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000354359-1313364_369517.0396.0RegionG5 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000354359-131342_55517.0396.0RegionG1 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371085-1313196_204516.0395.0RegionG2 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371085-1313219_228516.0395.0RegionG3 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371085-1313288_295516.0395.0RegionG4 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371085-1313364_369516.0395.0RegionG5 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371085-131342_55516.0395.0RegionG1 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371095-1212196_204502.0381.0RegionG2 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371095-1212219_228502.0381.0RegionG3 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371095-1212288_295502.0381.0RegionG4 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371095-1212364_369502.0381.0RegionG5 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371095-121242_55502.0381.0RegionG1 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371100-13131007_10121159.01038.0RegionG5 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371100-1313685_6981159.01038.0RegionG1 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371100-1313839_8471159.01038.0RegionG2 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371100-1313862_8711159.01038.0RegionG3 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371100-1313931_9381159.01038.0RegionG4 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371102-12121007_10121145.01024.0RegionG5 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371102-1212685_6981145.01024.0RegionG1 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371102-1212839_8471145.01024.0RegionG2 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371102-1212862_8711145.01024.0RegionG3 motif
HgeneGNASchr20:57486241chr3:124692749ENST00000371102-1212931_9381145.01024.0RegionG4 motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNASchr20:57486241chr3:124692749ENST00000306120-11238_4760.0626.0Compositional biasPro-rich
HgeneGNASchr20:57486241chr3:124692749ENST00000371098-1478_142020.333333333333332Compositional biasGlu-rich
TgeneHEG1chr20:57486241chr3:124692749ENST000003111271417463_7431273.66666666666671382.0Compositional biasNote=Ser-rich
TgeneHEG1chr20:57486241chr3:124692749ENST0000031112714171025_10631273.66666666666671382.0DomainEGF-like 2%3B calcium-binding
TgeneHEG1chr20:57486241chr3:124692749ENST000003111271417985_10231273.66666666666671382.0DomainEGF-like 1
TgeneHEG1chr20:57486241chr3:124692749ENST0000031112714171270_13811273.66666666666671382.0Topological domainCytoplasmic
TgeneHEG1chr20:57486241chr3:124692749ENST00000311127141730_12481273.66666666666671382.0Topological domainExtracellular
TgeneHEG1chr20:57486241chr3:124692749ENST0000031112714171249_12691273.66666666666671382.0TransmembraneHelical


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Fusion Gene Sequence for GNAS-HEG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000313949_ENST00000311127_TCGA-DJ-A13S-01A_GNAS_chr20_57486241_-_HEG1_chr3_124692749_length(transcript)=7845nt_BP=2578nt
AGAACCTCACTGCCCGTCCCTCCTCGCCTCAGTCTCCTCTGTCCTCTCCCAGGCAAGAGGACCGGCGGAGGCACCTCTCTCGAGTCTTAG
GCTGCGGAATCTAAGACTCAGCGAGAGGAGCCCGGGAGGAGACAGAACTTTCCCCTTTTTTCCCATCCCTTCTTCTTGCTCAGAGAGGCA
AGCAAGGCGCGGAGCTTTAGAAAGTTCTTAAGTGGTCAGGAAGGTAGGTGCTTCCCTTTTTCTCCTCACAAGGAGGTGAGGCTGGGACCT
CCGGGCCAGCTTCTCACCTCATAGGGTGTACCTTTCCCGGCTCCAGCAGCCAATGTGCTTCGGAGCCACTCTCTGCAGAGCCAGAGGGCA
GGCCGGCTTCTCGGTGTGTGCCTAAGAGGATGGATCGGAGGTCCCGGGCTCAGCAGTGGCGCCGAGCTCGCCATAATTACAACGACCTGT
GCCCGCCCATAGGCCGCCGGGCAGCCACCGCGCTCCTCTGGCTCTCCTGCTCCATCGCGCTCCTCCGCGCCCTTGCCACCTCCAACGCCC
GTGCCCAGCAGCGCGCGGCTGCCCAACAGCGCCGGAGCTTCCTTAACGCCCACCACCGCTCCGGCGCCCAGGTATTCCCTGAGTCCCCCG
AATCGGAATCTGACCACGAGCACGAGGAGGCAGACCTTGAGCTGTCCCTCCCCGAGTGCCTAGAGTACGAGGAAGAGTTCGACTACGAGA
CCGAGAGCGAGACCGAGTCCGAAATCGAGTCCGAGACCGACTTCGAGACCGAGCCTGAGACCGCCCCCACCACTGAGCCCGAGACCGAGC
CTGAAGACGATCGCGGCCCGGTGGTGCCCAAGCACTCCACCTTCGGCCAGTCCCTCACCCAGCGTCTGCACGCTCTCAAGTTGCGAAGCC
CCGACGCCTCCCCAAGTCGCGCGCCGCCCAGCACTCAGGAGCCCCAGAGCCCCAGGGAAGGGGAGGAGCTCAAGCCCGAGGACAAAGATC
CAAGGGACCCCGAAGAGTCGAAGGAGCCCAAGGAGGAGAAGCAGCGGCGTCGCTGCAAGCCAAAGAAGCCCACCCGCCGTGACGCGTCCC
CGGAGTCCCCTTCCAAAAAGGGACCCATCCCCATCCGGCGTCACTAATGGAGGACGCCGTCCAGATTCTCCTTGTTTTCATGGATTCAGG
TGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGAGGGCGGCGAAGAGGACCC
GCAGGCTGCAAGGAGCAACAGCGATGGTGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGGCGATTGAAACCATTGT
GGCCGCCATGAGCAACCTGGTGCCCCCCGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGTGTGATGAACGT
GCCTGACTTTGACTTCCCTCCCGAATTCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCTGCTACGAACGCTCCAA
CGAGTACCAGCTGATTGACTGTGCCCAGTACTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGACTATGTGCCGAGCGATCAGGACCT
GCTTCGCTGCCGTGTCCTGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGTTTGACGTGGGTGGCCA
GCGCGATGAACGCCGCAAGTGGATCCAGTGCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTACAACATGGTCAT
CCGGGAGGACAACCAGACCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGCTGCGCACCATCTCTGT
GATCCTGTTCCTCAACAAGCAAGATCTGCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGAGGACTACTTTCCAGAATTTGCTCG
CTACACTACTCCTGAGGATGCTACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTCGAGATGAGTTTCTGAG
GATCAGCACTGCCAGTGGAGATGGGCGTCACTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGCCGTGTGTTCAA
CGACTGCCGTGACATCATTCAGCGCATGCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTTAATTAAAGCCTTAAGC
ACAATTAATTAAAAGTGAAACGTAATTGTACAAGCAGTTAATCACCCACCATAGGGCATGATTAACAAAGCAACCTTTCCCTTCCCCCGA
GTGATTTTGCGAAACCCCCTTTTCCCTTCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTACAGAAAAAGGAAAAAAG
GCCACAAAAGTTCCCTCTCACTTTCAGTAAAAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAAGAAACAAATGAAATAA
ATATTGTGTTGTGCAGCATTAAAAAAAATCAAAATAAAAATTAAATGTGAGCAAAGAAAAAGAATAAAAATGACATAAGCAAACTCATCT
TCAAAAGTGGAGATTTCCAAATGTCCCCGTATGCTGAATACCCCAAAAATCCTCGCTCACAAGAATGGGGCCGAGAAGCTATTGAAATGC
ATGAGAATGGAAGTACCAAAAACCTCCTCCAGATGACGGATGTGTACTACTCGCCTACAAGTGTAAGGAATCCAGAACTTGAACGAAACG
GACTCTACCCGGCCTACACTGGACTGCCAGGATCACGGCATTCTTGCATTTTCCCCGGACAGTATAACCCGTCTTTCATCAGTGATGAAA
GCAGAAGAAGAGACTACTTTTAAGTCCAGGAGAGAGAGGGACTCATTGCTCTGAGCCAGTCACCTGGGACCTCTGCTCAGAGGACCGCAC
CAGGAGGCTGCGCCCAGGATTTGTCGGGAGCCACGCTGAGTGGCAAGCAGGAAGAGGGACAGGCATGCGGGGCGTGACCACAGTGGAGGA
GACAGGTGGATGTGGAACCACAGGCTGCTCATTCAGCACCTTTGTTGTTACTGTGAACGTGAATGTGGGCCAGTATCAAGAGAGTCTCTC
TGAGTGACTGCACCATGGCACTGGCACCAGGGCGACTATTAGCCAGGGCAGACCACTAGACTTCAGTGCAGGGACCTGGTTTTCCCTTCG
TTTGCACTTTAGTAAATTGGGTGGGAGGTTTCCTTTTGGATCTGTTTTGAGACTGTTCCAGAAAGAAGGCTTCCTTTCCCGAGACACTTC
CATAGGCAGCAATTTGGTGATTCATTTGCAGCAAAATACTGGCTTGTTAATTATTTTCCTGCCCAGCGCCTGCGTGCTAAACAACAGATG
AGGATGAGCGTACCACTGAAGTCTGAAGATGTCGCCATTGAACGGACAGTGTTTTCATATGTTTCTAGGTTGTCTTATGCTACAGTTTCC
AAGCCAGCCCCCACAGTGAGGAAATGTGTGAGGCACCGCACACAACTGCAATGTGTTTTTTAAGTCAAGGTGACACATGTATTTAAGATT
TTTTTTTTAAATCTCTTTGCAGTTAAATCTCACTTTTTCAAACAAGCCTGGATCAGGGCAAAACAACTTATATTTGGTTTTAGCTGGAGG
CTCAGCAGGCAGATTGCAGGCAGGGGGGCACTTTTCATCCATGAGGGCCCAGCCTGGGGCCTGGGACTCGATCACCATTGTGGAGGCCAG
AGGCAGCTGCGTATGGAGGAGAAATGTCAAACTGAACGCAGGTTTCACCACTCTAGGAAAGCAGCTTGTTGAGCCCCTGCAGCTGGATGT
GGTTAGAGGGATGGGCTGAATAGGCAGGTTAGATTTCCTGCATCAACAGTGCTTTGGGAAGCTGTGTGGATTCCTGAGGAAGAACAGGGA
GCCGAGATGGAGCCACACATGAGTTTGCTCACCGGCTACTGCAGCACTTTGTACCCAGAATCTCATGTCCACAAACCCCATGTAAACTTT
CAACCACTCAAAGCTGTTTATTCGGCTGAAGAAATAACTTTTTTTTCTCACCCAGTCATTTGTACCTCTTCATATGGCTATGTCGCACCC
TCCAGAAACGTGGTTATACTTCCAGTCAGTGTGGGAGAACTGAAGACTTCCGGTTGGTCGAGGAACTGAGGGTTGACCTTCGGGAAGGAA
GTTCCACTCATCTTATTTATTATGCCTGTGATGTGGGTCCTGCCAGGGAGACATCCAGTACTCGGTGTCTTTAATTGCCACCTGGGGAAC
TGTGTTTATTGGCCTTCTTTGGGGCATCCTGGTTTTGGATGAAGTGAGGGGAATACAGAGGTAAAAGAATTGTCTCCACCCTGAAGCGGG
GAGTCCCGCTTCACATTTCTGGAAATGGTGCAGCCACTGGGGACAGTTCTGCCCCGGGCATGGTTGTTTCTTCAAGGTCCTCTAAATATA
ATCCCTATTCTTACATAATCCTTGGCCCTGATGGTTTTAAGCAAGAACTCCTGTGTCCCATGGTCTCCACCACTCACCATCACCCTGCTG
TAGCAAGAGTCCTAGTCAGGGGAGGTGCATTTTAGTAGTTACATTGCACTTATCCATGAGATAAATAAAAGGAGAACTGTTTTTATCAGT
GGAGGCTAACCTAAAATTTCAAAGTGTCGCCTTTTTGAAATCTTGGGCCTCTCTCTCTGTAGAACCAATGGCCCTTTGTGGCTCACGGCC
TCGCACCTAACTGGAGAGTTCTGAGCTCCTGCAGCTCACCTGAGCCCACAGACTAGGCTTCTTGGCTCCTTCCGCAGCATGCCTGCTCAC
CCCCAGAACCCGCAGCTGTGGGAAGAGCCATGTAGGGAGGCTATTCCCAGGCATACACTTCCACTGCCTTCAGCTGACGTCACAGCTGAC
AAATCATCTCCTCTATCGGAGCCAGAAGACTTCAGCTCCACAAAATGAAGTGTTCTGTCCTGAAAACATTCTTGGGAAGAATCCCAACAT
CGAGAAAACGGTGTCCTGTGAGTTCCAACAATGCTTCTTGTTCATGGGTTTCTTCCGTATGGAGTGGATTAAGAGTGTTTTATTTTGTTG
TTCTAACTGAGAAAAAAAGGAGGCACCCACAAGGTTGAGGTCACACAGTCTCCACAGTTTCCAGGAGGCGTTTGGGGGTGGGGAAGGCAC
CTCCAGAGCATGAGGCTCTAAGGGGACATGAGTAAAGCATGTCTGTGACCCAGTGAGGAAGGGAGAGGCCAGCTGCACTCCTGCACGGGG
TTCCTAGCTGCAGAAGGGTCCCGCCTAGGCCGAGGGGAAACACCTGATAGCAGAAGAGGCCTGGATGCACACCTGGCACGCCGAGGCTCT
CCGCCCAGACACAGTGCTCCATGTCAGCCCCTGCACCTGGGGTGTGTGATTCACGTGCACAGATGCCACAATCCTGCACCAATATCCCAC
AGATGGGGGAAGGTGAGAGGAAGGGGCAAGTGATGTGTAACTGCTCAAGAGATGCTTAAACCTCCATAGAGAGGAGCCGGGCGCAGGGGC
ATCTGTGTGTCCCGTCACACACTGCAGCAGGGAAGGGTGGCTGGCTGGCTCCCTGGCATCAGTGGTTTGGTTTAAGCTCCAGAGGGTCTT
ATTGCCATTGTCTTTTCCTCTGCCCCTTGAGCCAGCCTAAGGCCCTGGAGTCTGTTTCTTTAGGCGGATGAACTGACATGCTCCTACCAT
GACCAGGCTCTGGGCAAGGCTCCTCACAGTATCCTTGAGAGGTGGGCATGGAAGTGCCCATTTCTCAGGTACAGAAACCTTCAGAGAGGA
TAAATAGCTTGCCCTGTAGAAGCAGGACTGAAACCCTTGTCTGCCTGACTCCCCCAGCTACTCTGCCCACTGTAGCCCCCTGCCTTACTG
TCCTGGCACACCCCTCACCATCCTGTATACCTTAAATATCAAAGAGGGCAAGAGAGAAAGGGCTTTAAAGATAAGTTATTTTTTTAAGGA
ACCTTAATATTATTTTTAAGAAGTAACCAAATTAGTGACGTGAAATGCAAAAAAAAAAAAAAAAAAATGCTGACTACCCTTTTGAAAATG
TGCTTTCAGATTGTTTTTTATATGTAATTCTTAGACACTTGTCATTAAGAAAATAGTGGCTGGCTTGTGCTCAGCAAGAAGCACACTGGC
ACGTGGCTTTGGTATAGGAAGTGGAAGGCAAGGACCTGGGTTTCTGACAAGTGCAGTCAGACATACACATCCATCTGAGAGCTGCTTGCC
TTGTTCCCGTGGTAAGGCCATGGCTCCCACATACTGGAAGCATATTTTTGTGAACTGTTTTCAGAATTGGGAACATATTCAGTGGAATGT
CTTAAACGCTGACACATCTTCCTCCTTTGAGGGGAAGTATATTTTCAGAAGCAGCTAAGACATTTAGAGCCAAAATTGCTGATAGGTGGT
TCAGTCAAGTTGGCTGATGGCATCTGAGGTCAAAAACTAAGATGTGACGATTGAGTTCTTAAAGAGGTAACTCTTAAAGTGGGCCCAAGG
GAGAAGGCAGCATCTTTGGACTCCTAGGCTGGATGGCTACCCAAGAATATGCCATTGAAGGATGACACCTATTCAGATGTGAAAGTTCCC
AGAGCAGGCACCTTTGGGTCACCCACCACGTGTGGCTTTTTGGTGCCTGCATGAAACTGTGTTGCCCCCTGGTGAGATGCCCGGGTGTCC
TGTAAGCCGATTTAACTCTGCCTGAGGAAGAGGAGCTGTCCACTCCAGTTGCCCTTGGCTAAGTTTAGCCTAACACACAGGGTTTTGACC
CATAGTTCTAAAATACACAAATTTTGAGACTACAGCACTTCTTTGGAAAGAGGAAGAATGCAAAGTTCAGTATTTCAATACTTTGTATTT
TACTTGAAATTACCCTTAGTAGCATCTTTTTTTTCCTGTCTGAAAGCTTTTGTGTGGATGAGAAGGGACATTTCATTTCCTCCCTTAACA
AAGTGTCATTCTGAGGTTCTCATGTGTGTTTTTGGAAATAGAGATACTGGTTTTGTAGAGTTTGCCTTTGGGTATGTTTTCTTTTTTTCT
TAAATCTCCAAGGAAGAGAACTGACTAAAATAGTAGGAACATGAAAGTATTAAATGCCAATTAATTTGTTGTAGTAAAGTATCTTCATTA
GCGTTATACTCCATCATATCTGGTGTAAACTGCTCACAGAAAACCCTATGAAACCAAAGGGGGACCATTCAGGTCTAAAAAGCGACAGGT
CCGAGACTGGGTCTGTCACCTGGGCATTTTCAAAGAGGACATTTTGAAGAATTTGCATATTCAGATTTTTAAAATGCACTTAACATACTT
CATTACAGATTTCTTGGGTAGGGAGGATGGGATAGGCCAGGGATGGGATGGAGTCAGTTCTGCCTGGGAAACTAATCCGAATCATTTACC
TTTCTGTATTAACCTTGGCCTGTCCTAAAAAGAGAACGACTGTTTCATCATGAGTTGCTCTGAGTTTTGTTAATGTTTGTGTTGGTGGAT
TGACGGTTAAATGAAGCATTTAGCTGGAATATGAACTTTGGGAGTTTTCATGTTGTCCTGGATTTCTCTTTGTAAACCTTTAAACCTTAG
CCCCTGGTTGATTGTGTTAAACCCATTATGAGAATGTTATTTAAAGTTGTATTATAATTGCAACCTCCACTAATTATTCAGTACTGTAGC
AGCAAAGTATTATTTGTAAGAATTTGGTTATTTTTATACTTATATCCACTCTAAGTCTGGCGTTCTAGTCAGTAAAATGATGCAATAAAA

>In-frame_ENST00000313949_ENST00000311127_TCGA-DJ-A13S-01A_GNAS_chr20_57486241_-_HEG1_chr3_124692749_length(amino acids)=362AA_start in transcript=1126_stop in transcript=2214
MEDAVQILLVFMDSGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANP
ENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKF
QVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVL
AGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYE

--------------------------------------------------------------
>In-frame_ENST00000371075_ENST00000311127_TCGA-DJ-A13S-01A_GNAS_chr20_57486241_-_HEG1_chr3_124692749_length(transcript)=7818nt_BP=2551nt
AGTCTCCTCTGTCCTCTCCCAGGCAAGAGGACCGGCGGAGGCACCTCTCTCGAGTCTTAGGCTGCGGAATCTAAGACTCAGCGAGAGGAG
CCCGGGAGGAGACAGAACTTTCCCCTTTTTTCCCATCCCTTCTTCTTGCTCAGAGAGGCAAGCAAGGCGCGGAGCTTTAGAAAGTTCTTA
AGTGGTCAGGAAGGTAGGTGCTTCCCTTTTTCTCCTCACAAGGAGGTGAGGCTGGGACCTCCGGGCCAGCTTCTCACCTCATAGGGTGTA
CCTTTCCCGGCTCCAGCAGCCAATGTGCTTCGGAGCCACTCTCTGCAGAGCCAGAGGGCAGGCCGGCTTCTCGGTGTGTGCCTAAGAGGA
TGGATCGGAGGTCCCGGGCTCAGCAGTGGCGCCGAGCTCGCCATAATTACAACGACCTGTGCCCGCCCATAGGCCGCCGGGCAGCCACCG
CGCTCCTCTGGCTCTCCTGCTCCATCGCGCTCCTCCGCGCCCTTGCCACCTCCAACGCCCGTGCCCAGCAGCGCGCGGCTGCCCAACAGC
GCCGGAGCTTCCTTAACGCCCACCACCGCTCCGGCGCCCAGGTATTCCCTGAGTCCCCCGAATCGGAATCTGACCACGAGCACGAGGAGG
CAGACCTTGAGCTGTCCCTCCCCGAGTGCCTAGAGTACGAGGAAGAGTTCGACTACGAGACCGAGAGCGAGACCGAGTCCGAAATCGAGT
CCGAGACCGACTTCGAGACCGAGCCTGAGACCGCCCCCACCACTGAGCCCGAGACCGAGCCTGAAGACGATCGCGGCCCGGTGGTGCCCA
AGCACTCCACCTTCGGCCAGTCCCTCACCCAGCGTCTGCACGCTCTCAAGTTGCGAAGCCCCGACGCCTCCCCAAGTCGCGCGCCGCCCA
GCACTCAGGAGCCCCAGAGCCCCAGGGAAGGGGAGGAGCTCAAGCCCGAGGACAAAGATCCAAGGGACCCCGAAGAGTCGAAGGAGCCCA
AGGAGGAGAAGCAGCGGCGTCGCTGCAAGCCAAAGAAGCCCACCCGCCGTGACGCGTCCCCGGAGTCCCCTTCCAAAAAGGGACCCATCC
CCATCCGGCGTCACTAATGGAGGACGCCGTCCAGATTCTCCTTGTTTTCATGGATTCAGGTGCTGGAGAATCTGGTAAAAGCACCATTGT
GAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGAGGGCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGCAG
TGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGGCGATTGAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCC
CGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGTGTGATGAACGTGCCTGACTTTGACTTCCCTCCCGAATT
CTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCTGCTACGAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCA
GTACTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGACTATGTGCCGAGCGATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGG
AATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGTTTGACGTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCA
GTGCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTACAACATGGTCATCCGGGAGGACAACCAGACCAACCGCCT
GCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGCTGCGCACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCT
GCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGAGGACTACTTTCCAGAATTTGCTCGCTACACTACTCCTGAGGATGCTACTCC
CGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTCGAGATGAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCG
TCACTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGCCGTGTGTTCAACGACTGCCGTGACATCATTCAGCGCAT
GCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTTAATTAAAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAATT
GTACAAGCAGTTAATCACCCACCATAGGGCATGATTAACAAAGCAACCTTTCCCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCT
TCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTACAGAAAAAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAG
TAAAAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAAGAAACAAATGAAATAAATATTGTGTTGTGCAGCATTAAAAAAA
ATCAAAATAAAAATTAAATGTGAGCAAAGAAAAAGAATAAAAATGACATAAGCAAACTCATCTTCAAAAGTGGAGATTTCCAAATGTCCC
CGTATGCTGAATACCCCAAAAATCCTCGCTCACAAGAATGGGGCCGAGAAGCTATTGAAATGCATGAGAATGGAAGTACCAAAAACCTCC
TCCAGATGACGGATGTGTACTACTCGCCTACAAGTGTAAGGAATCCAGAACTTGAACGAAACGGACTCTACCCGGCCTACACTGGACTGC
CAGGATCACGGCATTCTTGCATTTTCCCCGGACAGTATAACCCGTCTTTCATCAGTGATGAAAGCAGAAGAAGAGACTACTTTTAAGTCC
AGGAGAGAGAGGGACTCATTGCTCTGAGCCAGTCACCTGGGACCTCTGCTCAGAGGACCGCACCAGGAGGCTGCGCCCAGGATTTGTCGG
GAGCCACGCTGAGTGGCAAGCAGGAAGAGGGACAGGCATGCGGGGCGTGACCACAGTGGAGGAGACAGGTGGATGTGGAACCACAGGCTG
CTCATTCAGCACCTTTGTTGTTACTGTGAACGTGAATGTGGGCCAGTATCAAGAGAGTCTCTCTGAGTGACTGCACCATGGCACTGGCAC
CAGGGCGACTATTAGCCAGGGCAGACCACTAGACTTCAGTGCAGGGACCTGGTTTTCCCTTCGTTTGCACTTTAGTAAATTGGGTGGGAG
GTTTCCTTTTGGATCTGTTTTGAGACTGTTCCAGAAAGAAGGCTTCCTTTCCCGAGACACTTCCATAGGCAGCAATTTGGTGATTCATTT
GCAGCAAAATACTGGCTTGTTAATTATTTTCCTGCCCAGCGCCTGCGTGCTAAACAACAGATGAGGATGAGCGTACCACTGAAGTCTGAA
GATGTCGCCATTGAACGGACAGTGTTTTCATATGTTTCTAGGTTGTCTTATGCTACAGTTTCCAAGCCAGCCCCCACAGTGAGGAAATGT
GTGAGGCACCGCACACAACTGCAATGTGTTTTTTAAGTCAAGGTGACACATGTATTTAAGATTTTTTTTTTAAATCTCTTTGCAGTTAAA
TCTCACTTTTTCAAACAAGCCTGGATCAGGGCAAAACAACTTATATTTGGTTTTAGCTGGAGGCTCAGCAGGCAGATTGCAGGCAGGGGG
GCACTTTTCATCCATGAGGGCCCAGCCTGGGGCCTGGGACTCGATCACCATTGTGGAGGCCAGAGGCAGCTGCGTATGGAGGAGAAATGT
CAAACTGAACGCAGGTTTCACCACTCTAGGAAAGCAGCTTGTTGAGCCCCTGCAGCTGGATGTGGTTAGAGGGATGGGCTGAATAGGCAG
GTTAGATTTCCTGCATCAACAGTGCTTTGGGAAGCTGTGTGGATTCCTGAGGAAGAACAGGGAGCCGAGATGGAGCCACACATGAGTTTG
CTCACCGGCTACTGCAGCACTTTGTACCCAGAATCTCATGTCCACAAACCCCATGTAAACTTTCAACCACTCAAAGCTGTTTATTCGGCT
GAAGAAATAACTTTTTTTTCTCACCCAGTCATTTGTACCTCTTCATATGGCTATGTCGCACCCTCCAGAAACGTGGTTATACTTCCAGTC
AGTGTGGGAGAACTGAAGACTTCCGGTTGGTCGAGGAACTGAGGGTTGACCTTCGGGAAGGAAGTTCCACTCATCTTATTTATTATGCCT
GTGATGTGGGTCCTGCCAGGGAGACATCCAGTACTCGGTGTCTTTAATTGCCACCTGGGGAACTGTGTTTATTGGCCTTCTTTGGGGCAT
CCTGGTTTTGGATGAAGTGAGGGGAATACAGAGGTAAAAGAATTGTCTCCACCCTGAAGCGGGGAGTCCCGCTTCACATTTCTGGAAATG
GTGCAGCCACTGGGGACAGTTCTGCCCCGGGCATGGTTGTTTCTTCAAGGTCCTCTAAATATAATCCCTATTCTTACATAATCCTTGGCC
CTGATGGTTTTAAGCAAGAACTCCTGTGTCCCATGGTCTCCACCACTCACCATCACCCTGCTGTAGCAAGAGTCCTAGTCAGGGGAGGTG
CATTTTAGTAGTTACATTGCACTTATCCATGAGATAAATAAAAGGAGAACTGTTTTTATCAGTGGAGGCTAACCTAAAATTTCAAAGTGT
CGCCTTTTTGAAATCTTGGGCCTCTCTCTCTGTAGAACCAATGGCCCTTTGTGGCTCACGGCCTCGCACCTAACTGGAGAGTTCTGAGCT
CCTGCAGCTCACCTGAGCCCACAGACTAGGCTTCTTGGCTCCTTCCGCAGCATGCCTGCTCACCCCCAGAACCCGCAGCTGTGGGAAGAG
CCATGTAGGGAGGCTATTCCCAGGCATACACTTCCACTGCCTTCAGCTGACGTCACAGCTGACAAATCATCTCCTCTATCGGAGCCAGAA
GACTTCAGCTCCACAAAATGAAGTGTTCTGTCCTGAAAACATTCTTGGGAAGAATCCCAACATCGAGAAAACGGTGTCCTGTGAGTTCCA
ACAATGCTTCTTGTTCATGGGTTTCTTCCGTATGGAGTGGATTAAGAGTGTTTTATTTTGTTGTTCTAACTGAGAAAAAAAGGAGGCACC
CACAAGGTTGAGGTCACACAGTCTCCACAGTTTCCAGGAGGCGTTTGGGGGTGGGGAAGGCACCTCCAGAGCATGAGGCTCTAAGGGGAC
ATGAGTAAAGCATGTCTGTGACCCAGTGAGGAAGGGAGAGGCCAGCTGCACTCCTGCACGGGGTTCCTAGCTGCAGAAGGGTCCCGCCTA
GGCCGAGGGGAAACACCTGATAGCAGAAGAGGCCTGGATGCACACCTGGCACGCCGAGGCTCTCCGCCCAGACACAGTGCTCCATGTCAG
CCCCTGCACCTGGGGTGTGTGATTCACGTGCACAGATGCCACAATCCTGCACCAATATCCCACAGATGGGGGAAGGTGAGAGGAAGGGGC
AAGTGATGTGTAACTGCTCAAGAGATGCTTAAACCTCCATAGAGAGGAGCCGGGCGCAGGGGCATCTGTGTGTCCCGTCACACACTGCAG
CAGGGAAGGGTGGCTGGCTGGCTCCCTGGCATCAGTGGTTTGGTTTAAGCTCCAGAGGGTCTTATTGCCATTGTCTTTTCCTCTGCCCCT
TGAGCCAGCCTAAGGCCCTGGAGTCTGTTTCTTTAGGCGGATGAACTGACATGCTCCTACCATGACCAGGCTCTGGGCAAGGCTCCTCAC
AGTATCCTTGAGAGGTGGGCATGGAAGTGCCCATTTCTCAGGTACAGAAACCTTCAGAGAGGATAAATAGCTTGCCCTGTAGAAGCAGGA
CTGAAACCCTTGTCTGCCTGACTCCCCCAGCTACTCTGCCCACTGTAGCCCCCTGCCTTACTGTCCTGGCACACCCCTCACCATCCTGTA
TACCTTAAATATCAAAGAGGGCAAGAGAGAAAGGGCTTTAAAGATAAGTTATTTTTTTAAGGAACCTTAATATTATTTTTAAGAAGTAAC
CAAATTAGTGACGTGAAATGCAAAAAAAAAAAAAAAAAAATGCTGACTACCCTTTTGAAAATGTGCTTTCAGATTGTTTTTTATATGTAA
TTCTTAGACACTTGTCATTAAGAAAATAGTGGCTGGCTTGTGCTCAGCAAGAAGCACACTGGCACGTGGCTTTGGTATAGGAAGTGGAAG
GCAAGGACCTGGGTTTCTGACAAGTGCAGTCAGACATACACATCCATCTGAGAGCTGCTTGCCTTGTTCCCGTGGTAAGGCCATGGCTCC
CACATACTGGAAGCATATTTTTGTGAACTGTTTTCAGAATTGGGAACATATTCAGTGGAATGTCTTAAACGCTGACACATCTTCCTCCTT
TGAGGGGAAGTATATTTTCAGAAGCAGCTAAGACATTTAGAGCCAAAATTGCTGATAGGTGGTTCAGTCAAGTTGGCTGATGGCATCTGA
GGTCAAAAACTAAGATGTGACGATTGAGTTCTTAAAGAGGTAACTCTTAAAGTGGGCCCAAGGGAGAAGGCAGCATCTTTGGACTCCTAG
GCTGGATGGCTACCCAAGAATATGCCATTGAAGGATGACACCTATTCAGATGTGAAAGTTCCCAGAGCAGGCACCTTTGGGTCACCCACC
ACGTGTGGCTTTTTGGTGCCTGCATGAAACTGTGTTGCCCCCTGGTGAGATGCCCGGGTGTCCTGTAAGCCGATTTAACTCTGCCTGAGG
AAGAGGAGCTGTCCACTCCAGTTGCCCTTGGCTAAGTTTAGCCTAACACACAGGGTTTTGACCCATAGTTCTAAAATACACAAATTTTGA
GACTACAGCACTTCTTTGGAAAGAGGAAGAATGCAAAGTTCAGTATTTCAATACTTTGTATTTTACTTGAAATTACCCTTAGTAGCATCT
TTTTTTTCCTGTCTGAAAGCTTTTGTGTGGATGAGAAGGGACATTTCATTTCCTCCCTTAACAAAGTGTCATTCTGAGGTTCTCATGTGT
GTTTTTGGAAATAGAGATACTGGTTTTGTAGAGTTTGCCTTTGGGTATGTTTTCTTTTTTTCTTAAATCTCCAAGGAAGAGAACTGACTA
AAATAGTAGGAACATGAAAGTATTAAATGCCAATTAATTTGTTGTAGTAAAGTATCTTCATTAGCGTTATACTCCATCATATCTGGTGTA
AACTGCTCACAGAAAACCCTATGAAACCAAAGGGGGACCATTCAGGTCTAAAAAGCGACAGGTCCGAGACTGGGTCTGTCACCTGGGCAT
TTTCAAAGAGGACATTTTGAAGAATTTGCATATTCAGATTTTTAAAATGCACTTAACATACTTCATTACAGATTTCTTGGGTAGGGAGGA
TGGGATAGGCCAGGGATGGGATGGAGTCAGTTCTGCCTGGGAAACTAATCCGAATCATTTACCTTTCTGTATTAACCTTGGCCTGTCCTA
AAAAGAGAACGACTGTTTCATCATGAGTTGCTCTGAGTTTTGTTAATGTTTGTGTTGGTGGATTGACGGTTAAATGAAGCATTTAGCTGG
AATATGAACTTTGGGAGTTTTCATGTTGTCCTGGATTTCTCTTTGTAAACCTTTAAACCTTAGCCCCTGGTTGATTGTGTTAAACCCATT
ATGAGAATGTTATTTAAAGTTGTATTATAATTGCAACCTCCACTAATTATTCAGTACTGTAGCAGCAAAGTATTATTTGTAAGAATTTGG

>In-frame_ENST00000371075_ENST00000311127_TCGA-DJ-A13S-01A_GNAS_chr20_57486241_-_HEG1_chr3_124692749_length(amino acids)=363AA_start in transcript=1096_stop in transcript=2187
MEDAVQILLVFMDSGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGSEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELAN
PENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETK
FQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKV
LAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQY

--------------------------------------------------------------
>In-frame_ENST00000464624_ENST00000311127_TCGA-DJ-A13S-01A_GNAS_chr20_57486241_-_HEG1_chr3_124692749_length(transcript)=9031nt_BP=3764nt
GTTATGGGCGTGCGCAACTGCCTCTACGGCAATAATATGTCAGGACAACGCGATATCCCCCCTGAAATCGGGGAACAGCCCGAGCAACCA
CCTTTGGAGGCCCCAGGGGCAGCTGCCCCCGGTGCTGGGCCTAGCCCAGCCGAAGAGATGGAGACCGAACCGCCTCACAACGAGCCCATC
CCCGTCGAGAATGATGGCGAGGCCTGTGGACCCCCAGAGGTCTCCAGACCCAACTTTCAGGTCCTCAACCCGGCATTCAGGGAAGCTGGA
GCCCATGGAAGCTACAGCCCACCTCCTGAGGAAGCAATGCCCTTCGAGGCTGAACAGCCCAGCTTGGGAGGCTTCTGGCCTACACTGGAG
CAGCCTGGATTCCCCAGTGGGGTCCATGCAGGCCTTGAGGCCTTCGGCCCAGCACTCATGGAGCCCGGAGCCTTCAGTGGTGCCAGACCA
GGCCTGGGAGGATACAGCCCTCCACCAGAAGAAGCTATGCCCTTTGAGTTTGACCAGCCTGCCCAGAGAGGCTGCAGTCAACTTCTCTTA
CAGGTCCCAGACCTTGCTCCAGGAGGCCCAGGTGCTGCAGGGGTCCCCGGAGCTCCTCCCGAGGAGCCCCAAGCCCTCAGGCCTGCAAAG
GCTGGCTCCAGAGGAGGCTACAGCCCTCCCCCTGAGGAGACTATGCCATTTGAGCTTGATGGAGAAGGATTTGGGGACGACAGCCCACCC
CCGGGGCTTTCCCGAGTTATCGCACAAGTCGACGGCAGCAGCCAGTTCGCGGCAGTCGCGGCCTCGAGTGCGGTCCGCCTCACTCCCGCC
GCGAACGCGCCTCCCCTCTGGGTCCCAGGCGCCATCGGCAGCCCATCCCAAGAGGCTGTCAGACCTCCTTCTAACTTCACGGGCAGCAGC
CCCTGGATGGAGATCTCCGGACCCCCGTTCGAGATTGGCAGCGCCCCCGCTGGGGTCGACGACACTCCCGTCAACATGGACAGCCCCCCA
ATCGCGCTTGACGGCCCGCCCATCAAGGTCTCCGGAGCCCCAGATAAGAGAGAGCGAGCAGAGAGACCCCCAGTTGAGGAGGAAGCAGCA
GAGATGGAAGGAGCCGCTGATGCCGCGGAGGGAGGAAAAGTACCCTCTCCGGGGTACGGATCCCCTGCCGCCGGGGCAGCCTCAGCGGAT
ACCGCTGCCAGGGCAGCCCCTGCAGCCCCAGCCGATCCTGACTCCGGGGCAACCCCAGAAGATCCCGACTCCGGGACAGCACCAGCCGAT
CCTGACTCCGGGGCATTCGCAGCCGATCCCGACTCCGGGGCAGCCCCTGCCGCCCCAGCCGATCCCGACTCCGGGGCGGCCCCTGACGCC
CCAGCCGATCCCGACTCCGGGGCGGCCCCTGACGCCCCAGCCGATCCAGATGCCGGGGCGGCCCCTGAGGCTCCCGCCGCCCCTGCGGCT
GCTGAGACCCGGGCAGCCCATGTCGCCCCAGCTGCGCCAGACGCAGGGGCTCCCACTGCCCCAGCCGCTTCTGCCACCCGGGCAGCCCAA
GTCCGCCGGGCGGCCTCTGCAGCCCCTGCCTCCGGGGCCAGACGCAAGATCCATCTCAGACCCCCCAGCCCCGAGATCCAGGCTGCCGAT
CCGCCTACTCCGCGGCCTACTCGCGCGTCTGCCTGGCGGGGCAAGTCCGAGAGCAGCCGCGGCCGCCGCGTGTACTACGATGAAGGGGTG
GCCAGCAGCGACGATGACTCCAGCGGAGACGAGTCCGACGATGGGACCTCCGGATGCCTCCGCTGGTTTCAGCATCGGCGAAATCGCCGC
CGCCGAAAGCCCCAGCGCAACTTACTCCGCAACTTTCTCGTGCAAGCCTTCGGGGGCTGCTTCGGTCGATCTGAGAGTCCCCAGCCCAAA
GCCTCGCGCTCTCTCAAGGTCAAGAAGGTACCCCTGGCGGAGAAGCGCAGACAGATGCGCAAAGAAGCCCTGGAGAAGCGGGCCCAGAAG
CGCGCAGAGAAGAAACGCAGTAAGCTCATCGACAAACAACTCCAGGACGAAAAGATGGGCTACATGTGTACGCACCGCCTGCTGCTTCTA
GTCCGCCCCGCGCGCTCCTTGCCGAGGAGCCGAGCCCGCGCCCGGCCCGCCCGCCCGGCGCTGCCCCGGCCCTCCCGGCCCGCGTGAGGC
CGCCCGCGCCCGCCGCCGCCGCAGCCCGGCCGCGCCCCGCCGCCGCCGCCGCCGCCATGGGCTGCCTCGGGAACAGTAAGACCGAGGACC
AGCGCAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGGCCACGCACC
GCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGAGG
GCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGTGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGG
CGATTGAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCC
TGAGTGTGATGAACGTGCCTGACTTTGACTTCCCTCCCGAATTCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCT
GCTACGAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGTACTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGACTATGTGC
CGAGCGATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGT
TTGACGTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGTGCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCA
GCTACAACATGGTCATCCGGGAGGACAACCAGACCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGC
TGCGCACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGAGGACTACT
TTCCAGAATTTGCTCGCTACACTACTCCTGAGGATGCTACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTC
GAGATGAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTCACTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACA
TCCGCCGTGTGTTCAACGACTGCCGTGACATCATTCAGCGCATGCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTT
AATTAAAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAATTGTACAAGCAGTTAATCACCCACCATAGGGCATGATTAACAAAGCAAC
CTTTCCCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCTTCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTAC
AGAAAAAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAGTAAAAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAA
GAAACAAATGAAATAAATATTGTGTTGTGCAGCATTAAAAAAAATCAAAATAAAAATTAAATGTGAGCAAAGAAAAAGAATAAAAATGAC
ATAAGCAAACTCATCTTCAAAAGTGGAGATTTCCAAATGTCCCCGTATGCTGAATACCCCAAAAATCCTCGCTCACAAGAATGGGGCCGA
GAAGCTATTGAAATGCATGAGAATGGAAGTACCAAAAACCTCCTCCAGATGACGGATGTGTACTACTCGCCTACAAGTGTAAGGAATCCA
GAACTTGAACGAAACGGACTCTACCCGGCCTACACTGGACTGCCAGGATCACGGCATTCTTGCATTTTCCCCGGACAGTATAACCCGTCT
TTCATCAGTGATGAAAGCAGAAGAAGAGACTACTTTTAAGTCCAGGAGAGAGAGGGACTCATTGCTCTGAGCCAGTCACCTGGGACCTCT
GCTCAGAGGACCGCACCAGGAGGCTGCGCCCAGGATTTGTCGGGAGCCACGCTGAGTGGCAAGCAGGAAGAGGGACAGGCATGCGGGGCG
TGACCACAGTGGAGGAGACAGGTGGATGTGGAACCACAGGCTGCTCATTCAGCACCTTTGTTGTTACTGTGAACGTGAATGTGGGCCAGT
ATCAAGAGAGTCTCTCTGAGTGACTGCACCATGGCACTGGCACCAGGGCGACTATTAGCCAGGGCAGACCACTAGACTTCAGTGCAGGGA
CCTGGTTTTCCCTTCGTTTGCACTTTAGTAAATTGGGTGGGAGGTTTCCTTTTGGATCTGTTTTGAGACTGTTCCAGAAAGAAGGCTTCC
TTTCCCGAGACACTTCCATAGGCAGCAATTTGGTGATTCATTTGCAGCAAAATACTGGCTTGTTAATTATTTTCCTGCCCAGCGCCTGCG
TGCTAAACAACAGATGAGGATGAGCGTACCACTGAAGTCTGAAGATGTCGCCATTGAACGGACAGTGTTTTCATATGTTTCTAGGTTGTC
TTATGCTACAGTTTCCAAGCCAGCCCCCACAGTGAGGAAATGTGTGAGGCACCGCACACAACTGCAATGTGTTTTTTAAGTCAAGGTGAC
ACATGTATTTAAGATTTTTTTTTTAAATCTCTTTGCAGTTAAATCTCACTTTTTCAAACAAGCCTGGATCAGGGCAAAACAACTTATATT
TGGTTTTAGCTGGAGGCTCAGCAGGCAGATTGCAGGCAGGGGGGCACTTTTCATCCATGAGGGCCCAGCCTGGGGCCTGGGACTCGATCA
CCATTGTGGAGGCCAGAGGCAGCTGCGTATGGAGGAGAAATGTCAAACTGAACGCAGGTTTCACCACTCTAGGAAAGCAGCTTGTTGAGC
CCCTGCAGCTGGATGTGGTTAGAGGGATGGGCTGAATAGGCAGGTTAGATTTCCTGCATCAACAGTGCTTTGGGAAGCTGTGTGGATTCC
TGAGGAAGAACAGGGAGCCGAGATGGAGCCACACATGAGTTTGCTCACCGGCTACTGCAGCACTTTGTACCCAGAATCTCATGTCCACAA
ACCCCATGTAAACTTTCAACCACTCAAAGCTGTTTATTCGGCTGAAGAAATAACTTTTTTTTCTCACCCAGTCATTTGTACCTCTTCATA
TGGCTATGTCGCACCCTCCAGAAACGTGGTTATACTTCCAGTCAGTGTGGGAGAACTGAAGACTTCCGGTTGGTCGAGGAACTGAGGGTT
GACCTTCGGGAAGGAAGTTCCACTCATCTTATTTATTATGCCTGTGATGTGGGTCCTGCCAGGGAGACATCCAGTACTCGGTGTCTTTAA
TTGCCACCTGGGGAACTGTGTTTATTGGCCTTCTTTGGGGCATCCTGGTTTTGGATGAAGTGAGGGGAATACAGAGGTAAAAGAATTGTC
TCCACCCTGAAGCGGGGAGTCCCGCTTCACATTTCTGGAAATGGTGCAGCCACTGGGGACAGTTCTGCCCCGGGCATGGTTGTTTCTTCA
AGGTCCTCTAAATATAATCCCTATTCTTACATAATCCTTGGCCCTGATGGTTTTAAGCAAGAACTCCTGTGTCCCATGGTCTCCACCACT
CACCATCACCCTGCTGTAGCAAGAGTCCTAGTCAGGGGAGGTGCATTTTAGTAGTTACATTGCACTTATCCATGAGATAAATAAAAGGAG
AACTGTTTTTATCAGTGGAGGCTAACCTAAAATTTCAAAGTGTCGCCTTTTTGAAATCTTGGGCCTCTCTCTCTGTAGAACCAATGGCCC
TTTGTGGCTCACGGCCTCGCACCTAACTGGAGAGTTCTGAGCTCCTGCAGCTCACCTGAGCCCACAGACTAGGCTTCTTGGCTCCTTCCG
CAGCATGCCTGCTCACCCCCAGAACCCGCAGCTGTGGGAAGAGCCATGTAGGGAGGCTATTCCCAGGCATACACTTCCACTGCCTTCAGC
TGACGTCACAGCTGACAAATCATCTCCTCTATCGGAGCCAGAAGACTTCAGCTCCACAAAATGAAGTGTTCTGTCCTGAAAACATTCTTG
GGAAGAATCCCAACATCGAGAAAACGGTGTCCTGTGAGTTCCAACAATGCTTCTTGTTCATGGGTTTCTTCCGTATGGAGTGGATTAAGA
GTGTTTTATTTTGTTGTTCTAACTGAGAAAAAAAGGAGGCACCCACAAGGTTGAGGTCACACAGTCTCCACAGTTTCCAGGAGGCGTTTG
GGGGTGGGGAAGGCACCTCCAGAGCATGAGGCTCTAAGGGGACATGAGTAAAGCATGTCTGTGACCCAGTGAGGAAGGGAGAGGCCAGCT
GCACTCCTGCACGGGGTTCCTAGCTGCAGAAGGGTCCCGCCTAGGCCGAGGGGAAACACCTGATAGCAGAAGAGGCCTGGATGCACACCT
GGCACGCCGAGGCTCTCCGCCCAGACACAGTGCTCCATGTCAGCCCCTGCACCTGGGGTGTGTGATTCACGTGCACAGATGCCACAATCC
TGCACCAATATCCCACAGATGGGGGAAGGTGAGAGGAAGGGGCAAGTGATGTGTAACTGCTCAAGAGATGCTTAAACCTCCATAGAGAGG
AGCCGGGCGCAGGGGCATCTGTGTGTCCCGTCACACACTGCAGCAGGGAAGGGTGGCTGGCTGGCTCCCTGGCATCAGTGGTTTGGTTTA
AGCTCCAGAGGGTCTTATTGCCATTGTCTTTTCCTCTGCCCCTTGAGCCAGCCTAAGGCCCTGGAGTCTGTTTCTTTAGGCGGATGAACT
GACATGCTCCTACCATGACCAGGCTCTGGGCAAGGCTCCTCACAGTATCCTTGAGAGGTGGGCATGGAAGTGCCCATTTCTCAGGTACAG
AAACCTTCAGAGAGGATAAATAGCTTGCCCTGTAGAAGCAGGACTGAAACCCTTGTCTGCCTGACTCCCCCAGCTACTCTGCCCACTGTA
GCCCCCTGCCTTACTGTCCTGGCACACCCCTCACCATCCTGTATACCTTAAATATCAAAGAGGGCAAGAGAGAAAGGGCTTTAAAGATAA
GTTATTTTTTTAAGGAACCTTAATATTATTTTTAAGAAGTAACCAAATTAGTGACGTGAAATGCAAAAAAAAAAAAAAAAAAATGCTGAC
TACCCTTTTGAAAATGTGCTTTCAGATTGTTTTTTATATGTAATTCTTAGACACTTGTCATTAAGAAAATAGTGGCTGGCTTGTGCTCAG
CAAGAAGCACACTGGCACGTGGCTTTGGTATAGGAAGTGGAAGGCAAGGACCTGGGTTTCTGACAAGTGCAGTCAGACATACACATCCAT
CTGAGAGCTGCTTGCCTTGTTCCCGTGGTAAGGCCATGGCTCCCACATACTGGAAGCATATTTTTGTGAACTGTTTTCAGAATTGGGAAC
ATATTCAGTGGAATGTCTTAAACGCTGACACATCTTCCTCCTTTGAGGGGAAGTATATTTTCAGAAGCAGCTAAGACATTTAGAGCCAAA
ATTGCTGATAGGTGGTTCAGTCAAGTTGGCTGATGGCATCTGAGGTCAAAAACTAAGATGTGACGATTGAGTTCTTAAAGAGGTAACTCT
TAAAGTGGGCCCAAGGGAGAAGGCAGCATCTTTGGACTCCTAGGCTGGATGGCTACCCAAGAATATGCCATTGAAGGATGACACCTATTC
AGATGTGAAAGTTCCCAGAGCAGGCACCTTTGGGTCACCCACCACGTGTGGCTTTTTGGTGCCTGCATGAAACTGTGTTGCCCCCTGGTG
AGATGCCCGGGTGTCCTGTAAGCCGATTTAACTCTGCCTGAGGAAGAGGAGCTGTCCACTCCAGTTGCCCTTGGCTAAGTTTAGCCTAAC
ACACAGGGTTTTGACCCATAGTTCTAAAATACACAAATTTTGAGACTACAGCACTTCTTTGGAAAGAGGAAGAATGCAAAGTTCAGTATT
TCAATACTTTGTATTTTACTTGAAATTACCCTTAGTAGCATCTTTTTTTTCCTGTCTGAAAGCTTTTGTGTGGATGAGAAGGGACATTTC
ATTTCCTCCCTTAACAAAGTGTCATTCTGAGGTTCTCATGTGTGTTTTTGGAAATAGAGATACTGGTTTTGTAGAGTTTGCCTTTGGGTA
TGTTTTCTTTTTTTCTTAAATCTCCAAGGAAGAGAACTGACTAAAATAGTAGGAACATGAAAGTATTAAATGCCAATTAATTTGTTGTAG
TAAAGTATCTTCATTAGCGTTATACTCCATCATATCTGGTGTAAACTGCTCACAGAAAACCCTATGAAACCAAAGGGGGACCATTCAGGT
CTAAAAAGCGACAGGTCCGAGACTGGGTCTGTCACCTGGGCATTTTCAAAGAGGACATTTTGAAGAATTTGCATATTCAGATTTTTAAAA
TGCACTTAACATACTTCATTACAGATTTCTTGGGTAGGGAGGATGGGATAGGCCAGGGATGGGATGGAGTCAGTTCTGCCTGGGAAACTA
ATCCGAATCATTTACCTTTCTGTATTAACCTTGGCCTGTCCTAAAAAGAGAACGACTGTTTCATCATGAGTTGCTCTGAGTTTTGTTAAT
GTTTGTGTTGGTGGATTGACGGTTAAATGAAGCATTTAGCTGGAATATGAACTTTGGGAGTTTTCATGTTGTCCTGGATTTCTCTTTGTA
AACCTTTAAACCTTAGCCCCTGGTTGATTGTGTTAAACCCATTATGAGAATGTTATTTAAAGTTGTATTATAATTGCAACCTCCACTAAT
TATTCAGTACTGTAGCAGCAAAGTATTATTTGTAAGAATTTGGTTATTTTTATACTTATATCCACTCTAAGTCTGGCGTTCTAGTCAGTA

>In-frame_ENST00000464624_ENST00000311127_TCGA-DJ-A13S-01A_GNAS_chr20_57486241_-_HEG1_chr3_124692749_length(amino acids)=717AA_start in transcript=3_stop in transcript=2156
MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNPAFREAGA
HGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQ
VPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSAVRLTPAA
NAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE
MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAP
ADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADP
PTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRSESPQPKA

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Fusion Gene PPI Analysis for GNAS-HEG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GNAS-HEG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GNAS-HEG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGNASC3494506Pseudohypoparathyroidism, Type Ia17CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGNASC0242292McCune-Albright Syndrome7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGNASC0016065Polyostotic fibrous dysplasia5CTD_human;ORPHANET
HgeneGNASC1864100PSEUDOHYPOPARATHYROIDISM, TYPE IB5CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneGNASC2931404Albright's hereditary osteodystrophy4CTD_human;GENOMICS_ENGLAND
HgeneGNASC0033806Pseudohypoparathyroidism3CTD_human
HgeneGNASC0334041Osteoma cutis3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGNASC0014130Endocrine System Diseases2CTD_human
HgeneGNASC0016064Fibrous Dysplasia, Monostotic2ORPHANET
HgeneGNASC0034013Precocious Puberty2CTD_human
HgeneGNASC0221263Cafe-au-Lait Spots2CTD_human
HgeneGNASC0271527Cryptogenic sexual precocity2CTD_human
HgeneGNASC0342543Central Precocious Puberty2CTD_human
HgeneGNASC1504412Testotoxicosis2CTD_human
HgeneGNASC1857451Acth-Independent Macronodular Adrenal Hyperplasia2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGNASC2932716Pseudohypoparathyroidism Type 1C2GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGNASC0001206Acromegaly1CTD_human
HgeneGNASC0001624Adrenal Gland Neoplasms1CTD_human
HgeneGNASC0003129Anoxemia1CTD_human
HgeneGNASC0003130Anoxia1CTD_human
HgeneGNASC0008370Cholestasis1GENOMICS_ENGLAND
HgeneGNASC0009438Common Bile Duct Calculi1CTD_human
HgeneGNASC0011573Endogenous depression1PSYGENET
HgeneGNASC0019087Hemorrhagic Disorders1CTD_human
HgeneGNASC0020538Hypertensive disease1CTD_human
HgeneGNASC0020796Profound Mental Retardation1CTD_human
HgeneGNASC0021655Insulin Resistance1CTD_human
HgeneGNASC0023897Liver Diseases, Parasitic1CTD_human
HgeneGNASC0025363Mental Retardation, Psychosocial1CTD_human
HgeneGNASC0027819Neuroblastoma1CTD_human
HgeneGNASC0028754Obesity1CTD_human
HgeneGNASC0029396Heterotopic Ossification1CTD_human
HgeneGNASC0032460Polycystic Ovary Syndrome1CTD_human
HgeneGNASC0033835Pseudopseudohypoparathyroidism1CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneGNASC0035204Respiration Disorders1CTD_human
HgeneGNASC0036341Schizophrenia1PSYGENET
HgeneGNASC0038587Substance Withdrawal Syndrome1CTD_human
HgeneGNASC0039231Tachycardia1CTD_human
HgeneGNASC0080203Tachyarrhythmia1CTD_human
HgeneGNASC0086189Drug Withdrawal Symptoms1CTD_human
HgeneGNASC0087169Withdrawal Symptoms1CTD_human
HgeneGNASC0206698Cholangiocarcinoma1CTD_human
HgeneGNASC0221357Brachydactyly1CTD_human
HgeneGNASC0242184Hypoxia1CTD_human
HgeneGNASC0242216Biliary calculi1CTD_human
HgeneGNASC0345905Intrahepatic Cholangiocarcinoma1CTD_human
HgeneGNASC0346302Growth Hormone-Secreting Pituitary Adenoma1CTD_human
HgeneGNASC0700292Hypoxemia1CTD_human
HgeneGNASC0750887Adrenal Cancer1CTD_human
HgeneGNASC0917816Mental deficiency1CTD_human
HgeneGNASC0920563Insulin Sensitivity1CTD_human
HgeneGNASC1136382Sclerocystic Ovaries1CTD_human
HgeneGNASC2932715Pseudohypoparathyroidism Type 1B1CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneGNASC3489630Somatotrophinoma, Familial1CTD_human
HgeneGNASC3697137Fibrous dysplasia of bone with intramuscular myxoma1ORPHANET
HgeneGNASC3714756Intellectual Disability1CTD_human
HgeneGNASC3805278Extrahepatic Cholangiocarcinoma1CTD_human