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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GNAS-SIAE (FusionGDB2 ID:33526)

Fusion Gene Summary for GNAS-SIAE

check button Fusion gene summary
Fusion gene informationFusion gene name: GNAS-SIAE
Fusion gene ID: 33526
HgeneTgene
Gene symbol

GNAS

SIAE

Gene ID

2778

54414

Gene nameGNAS complex locussialic acid acetylesterase
SynonymsAHO|C20orf45|GNAS1|GPSA|GSA|GSP|NESP|PITA3|POH|SCG6|SgVIAIS6|CSE-C|CSEC|LSE|YSG2
Cytomap

20q13.32

11q24.2

Type of geneprotein-codingprotein-coding
Descriptionprotein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha sialate O-acetylesteraseH-Lsecytosolic sialic acid 9-O-acetylesterase homologsialic acid-specific acetylesterase II
Modification date2020032920200313
UniProtAcc

P63092

.
Ensembl transtripts involved in fusion geneENST00000313949, ENST00000371098, 
ENST00000371075, ENST00000371100, 
ENST00000371099, ENST00000371102, 
ENST00000464624, ENST00000306120, 
ENST00000371095, ENST00000371085, 
ENST00000354359, ENST00000265620, 
ENST00000306090, ENST00000371081, 
ENST00000263593, ENST00000545756, 
ENST00000525730, 
Fusion gene scores* DoF score44 X 25 X 16=1760034 X 6 X 15=3060
# samples 5134
** MAII scorelog2(51/17600*10)=-5.10893437155316
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(34/3060*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNAS [Title/Abstract] AND SIAE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGNAS(57486241)-SIAE(124543777), # samples:2
Anticipated loss of major functional domain due to fusion event.GNAS-SIAE seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
GNAS-SIAE seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSIAE

GO:0005975

carbohydrate metabolic process

23308225


check buttonFusion gene breakpoints across GNAS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SIAE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-BJ-A192-01AGNASchr20

57486241

-SIAEchr11

124543777

-
ChimerDB4THCATCGA-ET-A3BQ-01BGNASchr20

57486241

-SIAEchr11

124543777

-


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Fusion Gene ORF analysis for GNAS-SIAE

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000313949ENST00000263593GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000313949ENST00000545756GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000313949ENST00000525730GNASchr20

57486241

-SIAEchr11

124543777

-
intron-3CDSENST00000371098ENST00000263593GNASchr20

57486241

-SIAEchr11

124543777

-
intron-intronENST00000371098ENST00000545756GNASchr20

57486241

-SIAEchr11

124543777

-
intron-intronENST00000371098ENST00000525730GNASchr20

57486241

-SIAEchr11

124543777

-
Frame-shiftENST00000371075ENST00000263593GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000371075ENST00000545756GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000371075ENST00000525730GNASchr20

57486241

-SIAEchr11

124543777

-
In-frameENST00000371100ENST00000263593GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000371100ENST00000545756GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000371100ENST00000525730GNASchr20

57486241

-SIAEchr11

124543777

-
intron-3CDSENST00000371099ENST00000263593GNASchr20

57486241

-SIAEchr11

124543777

-
intron-intronENST00000371099ENST00000545756GNASchr20

57486241

-SIAEchr11

124543777

-
intron-intronENST00000371099ENST00000525730GNASchr20

57486241

-SIAEchr11

124543777

-
In-frameENST00000371102ENST00000263593GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000371102ENST00000545756GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000371102ENST00000525730GNASchr20

57486241

-SIAEchr11

124543777

-
Frame-shiftENST00000464624ENST00000263593GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000464624ENST00000545756GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000464624ENST00000525730GNASchr20

57486241

-SIAEchr11

124543777

-
intron-3CDSENST00000306120ENST00000263593GNASchr20

57486241

-SIAEchr11

124543777

-
intron-intronENST00000306120ENST00000545756GNASchr20

57486241

-SIAEchr11

124543777

-
intron-intronENST00000306120ENST00000525730GNASchr20

57486241

-SIAEchr11

124543777

-
In-frameENST00000371095ENST00000263593GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000371095ENST00000545756GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000371095ENST00000525730GNASchr20

57486241

-SIAEchr11

124543777

-
In-frameENST00000371085ENST00000263593GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000371085ENST00000545756GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000371085ENST00000525730GNASchr20

57486241

-SIAEchr11

124543777

-
In-frameENST00000354359ENST00000263593GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000354359ENST00000545756GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000354359ENST00000525730GNASchr20

57486241

-SIAEchr11

124543777

-
In-frameENST00000265620ENST00000263593GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000265620ENST00000545756GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000265620ENST00000525730GNASchr20

57486241

-SIAEchr11

124543777

-
In-frameENST00000306090ENST00000263593GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000306090ENST00000545756GNASchr20

57486241

-SIAEchr11

124543777

-
5CDS-intronENST00000306090ENST00000525730GNASchr20

57486241

-SIAEchr11

124543777

-
intron-3CDSENST00000371081ENST00000263593GNASchr20

57486241

-SIAEchr11

124543777

-
intron-intronENST00000371081ENST00000545756GNASchr20

57486241

-SIAEchr11

124543777

-
intron-intronENST00000371081ENST00000525730GNASchr20

57486241

-SIAEchr11

124543777

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371100GNASchr2057486241-ENST00000263593SIAEchr11124543777-9612402953136651044
ENST00000371102GNASchr2057486241-ENST00000263593SIAEchr11124543777-90213438330741023
ENST00000371095GNASchr2057486241-ENST00000263593SIAEchr11124543777-7514193118763675599
ENST00000371085GNASchr2057486241-ENST00000263593SIAEchr11124543777-7555197219173716599
ENST00000354359GNASchr2057486241-ENST00000263593SIAEchr11124543777-7558197519203719599
ENST00000265620GNASchr2057486241-ENST00000263593SIAEchr11124543777-7449186618113610599
ENST00000306090GNASchr2057486241-ENST00000263593SIAEchr11124543777-7225164215933386597

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371100ENST00000263593GNASchr2057486241-SIAEchr11124543777-0.0008226420.9991774
ENST00000371102ENST00000263593GNASchr2057486241-SIAEchr11124543777-0.0003496730.99965036
ENST00000371095ENST00000263593GNASchr2057486241-SIAEchr11124543777-0.0006026090.9993974
ENST00000371085ENST00000263593GNASchr2057486241-SIAEchr11124543777-0.0006399390.99936
ENST00000354359ENST00000263593GNASchr2057486241-SIAEchr11124543777-0.000646620.99935335
ENST00000265620ENST00000263593GNASchr2057486241-SIAEchr11124543777-0.0005860540.99941397
ENST00000306090ENST00000263593GNASchr2057486241-SIAEchr11124543777-0.0005118570.9994881

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Fusion Genomic Features for GNAS-SIAE


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GNAS-SIAE


check button Go to

FGviewer for the breakpoints of chr20:57486241-chr11:124543777

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNAS

P63092

.
FUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161). {ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:17110384, ECO:0000269|PubMed:21488135, ECO:0000269|PubMed:26206488, ECO:0000269|PubMed:8702665}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313641_6671159.01038.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313730_7561159.01038.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212641_6671145.01024.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212730_7561145.01024.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr11:124543777ENST00000313949-131378_142729.666666666666626.333333333333332Compositional biasGlu-rich
HgeneGNASchr20:57486241chr11:124543777ENST00000371075-131378_142730.666666666666636.333333333333336Compositional biasGlu-rich
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313358_5221159.01038.0Compositional biasAla-rich
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212358_5221145.01024.0Compositional biasAla-rich
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-121239_394501.0380.0DomainG-alpha
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-131339_394500.0381.0DomainG-alpha
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-131339_394517.0396.0DomainG-alpha
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-131339_394516.0395.0DomainG-alpha
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-121239_394502.0381.0DomainG-alpha
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313682_10371159.01038.0DomainG-alpha
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212682_10371145.01024.0DomainG-alpha
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-1212197_204501.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-1212223_227501.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-1212292_295501.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-121247_55501.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-1313197_204500.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-1313223_227500.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-1313292_295500.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-131347_55500.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-1313197_204517.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-1313223_227517.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-1313292_295517.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-131347_55517.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-1313197_204516.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-1313223_227516.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-1313292_295516.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-131347_55516.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-1212197_204502.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-1212223_227502.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-1212292_295502.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-121247_55502.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313690_6981159.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313840_8471159.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313866_8701159.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313935_9381159.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212690_6981145.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212840_8471145.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212866_8701145.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212935_9381145.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-1212196_204501.0380.0RegionG2 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-1212219_228501.0380.0RegionG3 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-1212288_295501.0380.0RegionG4 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-1212364_369501.0380.0RegionG5 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-121242_55501.0380.0RegionG1 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-1313196_204500.0381.0RegionG2 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-1313219_228500.0381.0RegionG3 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-1313288_295500.0381.0RegionG4 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-1313364_369500.0381.0RegionG5 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-131342_55500.0381.0RegionG1 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-1313196_204517.0396.0RegionG2 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-1313219_228517.0396.0RegionG3 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-1313288_295517.0396.0RegionG4 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-1313364_369517.0396.0RegionG5 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-131342_55517.0396.0RegionG1 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-1313196_204516.0395.0RegionG2 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-1313219_228516.0395.0RegionG3 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-1313288_295516.0395.0RegionG4 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-1313364_369516.0395.0RegionG5 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-131342_55516.0395.0RegionG1 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-1212196_204502.0381.0RegionG2 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-1212219_228502.0381.0RegionG3 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-1212288_295502.0381.0RegionG4 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-1212364_369502.0381.0RegionG5 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-121242_55502.0381.0RegionG1 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-13131007_10121159.01038.0RegionG5 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313685_6981159.01038.0RegionG1 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313839_8471159.01038.0RegionG2 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313862_8711159.01038.0RegionG3 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313931_9381159.01038.0RegionG4 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-12121007_10121145.01024.0RegionG5 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212685_6981145.01024.0RegionG1 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212839_8471145.01024.0RegionG2 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212862_8711145.01024.0RegionG3 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212931_9381145.01024.0RegionG4 motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNASchr20:57486241chr11:124543777ENST00000306120-11238_4760.0626.0Compositional biasPro-rich
HgeneGNASchr20:57486241chr11:124543777ENST00000371098-1478_142020.333333333333332Compositional biasGlu-rich


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Fusion Gene Sequence for GNAS-SIAE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000371100_ENST00000263593_TCGA-BJ-A192-01A_GNAS_chr20_57486241_-_SIAE_chr11_124543777_length(transcript)=9612nt_BP=4029nt
AAAGACTCCAAATCAGTCAGGGAGAGGAGTGGAAGGAGCCAAAACGTCCCTGCGAGGCCTGCGCTCACCAGCCCCCTTACCCAAAGTCCC
GGGCCCCTGGCGCCAGGAGCAGGCTCCTGGAGCCGGAGCCAGCTCGGCACTGGAACCGGCGTCCTCTGGTGGCAGAGAGAGAGCGCTACT
GGCGATTTTCGGACCGAATCGGCACGCTCGTCAGATCCAAGCAGGCGGGACTGGCCTGGAGCAAAAAGAAAGAGAGAGGAGGGCGTAAGG
ATAGACCAAGGAAGAGGGGCTGGGGGGCAGCCTGGGGGCATGAAAAGTGGCCAGGAAGGAGCCAAGACTCCACCAGCAACAATTGAGTTG
CTTCAGCCTCAGTCTAGGGTTCCTTCCAGGCCTTGAACCCCCCAACCTCACAAGGGTTGGAAAGTGAGGCCGGTGAACTTTCCAGCTGGT
ACTTTGATTTTAAAATAATAATAATAATTTTTTCACCCTAGTTCGGTTGGGTGCTCCATCTTACGGAGCCCCAAACTTATTTTGAGAGGC
CGCCACCGTGTTATGGGCGTGCGCAACTGCCTCTACGGCAATAATATGTCAGGACAACGCGATATCCCCCCTGAAATCGGGGAACAGCCC
GAGCAACCACCTTTGGAGGCCCCAGGGGCAGCTGCCCCCGGTGCTGGGCCTAGCCCAGCCGAAGAGATGGAGACCGAACCGCCTCACAAC
GAGCCCATCCCCGTCGAGAATGATGGCGAGGCCTGTGGACCCCCAGAGGTCTCCAGACCCAACTTTCAGGTCCTCAACCCGGCATTCAGG
GAAGCTGGAGCCCATGGAAGCTACAGCCCACCTCCTGAGGAAGCAATGCCCTTCGAGGCTGAACAGCCCAGCTTGGGAGGCTTCTGGCCT
ACACTGGAGCAGCCTGGATTCCCCAGTGGGGTCCATGCAGGCCTTGAGGCCTTCGGCCCAGCACTCATGGAGCCCGGAGCCTTCAGTGGT
GCCAGACCAGGCCTGGGAGGATACAGCCCTCCACCAGAAGAAGCTATGCCCTTTGAGTTTGACCAGCCTGCCCAGAGAGGCTGCAGTCAA
CTTCTCTTACAGGTCCCAGACCTTGCTCCAGGAGGCCCAGGTGCTGCAGGGGTCCCCGGAGCTCCTCCCGAGGAGCCCCAAGCCCTCAGG
CCTGCAAAGGCTGGCTCCAGAGGAGGCTACAGCCCTCCCCCTGAGGAGACTATGCCATTTGAGCTTGATGGAGAAGGATTTGGGGACGAC
AGCCCACCCCCGGGGCTTTCCCGAGTTATCGCACAAGTCGACGGCAGCAGCCAGTTCGCGGCAGTCGCGGCCTCGAGTGCGGTCCGCCTC
ACTCCCGCCGCGAACGCGCCTCCCCTCTGGGTCCCAGGCGCCATCGGCAGCCCATCCCAAGAGGCTGTCAGACCTCCTTCTAACTTCACG
GGCAGCAGCCCCTGGATGGAGATCTCCGGACCCCCGTTCGAGATTGGCAGCGCCCCCGCTGGGGTCGACGACACTCCCGTCAACATGGAC
AGCCCCCCAATCGCGCTTGACGGCCCGCCCATCAAGGTCTCCGGAGCCCCAGATAAGAGAGAGCGAGCAGAGAGACCCCCAGTTGAGGAG
GAAGCAGCAGAGATGGAAGGAGCCGCTGATGCCGCGGAGGGAGGAAAAGTACCCTCTCCGGGGTACGGATCCCCTGCCGCCGGGGCAGCC
TCAGCGGATACCGCTGCCAGGGCAGCCCCTGCAGCCCCAGCCGATCCTGACTCCGGGGCAACCCCAGAAGATCCCGACTCCGGGACAGCA
CCAGCCGATCCTGACTCCGGGGCATTCGCAGCCGATCCCGACTCCGGGGCAGCCCCTGCCGCCCCAGCCGATCCCGACTCCGGGGCGGCC
CCTGACGCCCCAGCCGATCCCGACTCCGGGGCGGCCCCTGACGCCCCAGCCGATCCAGATGCCGGGGCGGCCCCTGAGGCTCCCGCCGCC
CCTGCGGCTGCTGAGACCCGGGCAGCCCATGTCGCCCCAGCTGCGCCAGACGCAGGGGCTCCCACTGCCCCAGCCGCTTCTGCCACCCGG
GCAGCCCAAGTCCGCCGGGCGGCCTCTGCAGCCCCTGCCTCCGGGGCCAGACGCAAGATCCATCTCAGACCCCCCAGCCCCGAGATCCAG
GCTGCCGATCCGCCTACTCCGCGGCCTACTCGCGCGTCTGCCTGGCGGGGCAAGTCCGAGAGCAGCCGCGGCCGCCGCGTGTACTACGAT
GAAGGGGTGGCCAGCAGCGACGATGACTCCAGCGGAGACGAGTCCGACGATGGGACCTCCGGATGCCTCCGCTGGTTTCAGCATCGGCGA
AATCGCCGCCGCCGAAAGCCCCAGCGCAACTTACTCCGCAACTTTCTCGTGCAAGCCTTCGGGGGCTGCTTCGGTCGATCTGAGAGTCCC
CAGCCCAAAGCCTCGCGCTCTCTCAAGGTCAAGAAGGTACCCCTGGCGGAGAAGCGCAGACAGATGCGCAAAGAAGCCCTGGAGAAGCGG
GCCCAGAAGCGCGCAGAGAAGAAACGCAGTAAGCTCATCGACAAACAACTCCAGGACGAAAAGATGGGCTACATGTGTACGCACCGCCTG
CTGCTTCTAGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGAGGGCGGC
GAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGTGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGGCGATT
GAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGT
GTGATGAACGTGCCTGACTTTGACTTCCCTCCCGAATTCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCTGCTAC
GAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGTACTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGACTATGTGCCGAGC
GATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGTTTGAC
GTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGTGCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTAC
AACATGGTCATCCGGGAGGACAACCAGACCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGCTGCGC
ACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGAGGACTACTTTCCA
GAATTTGCTCGCTACACTACTCCTGAGGATGCTACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTCGAGAT
GAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTCACTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGC
CGTGTGTTCAACGACTGCCGTGACATCATTCAGCGCATGCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTTAATTA
AAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAATTGTACAAGCAGTTAATCACCCACCATAGGGCATGATTAACAAAGCAACCTTTC
CCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCTTCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTACAGAAA
AAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAGTAAAAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAAGAAAC
AAATGAAATAAATATTGTGTTGTGCAGCATTAAAAAAAATCAAAATAAAAATTAAATGTGAGCAAAGAAAAAAAAAAAAAAAAACTACGG
CGGCCGAGAAGGGGCGAGTACAGCCCAGTCCTGAGGTCGCGGGAGGCTGCGAGGACTGCAAAAGGGTGGAGTCGGCCTCGCCCCCGCCCA
GGCCCCGCCCCTGCCGGGAACCCACTTTCCCAGTCCTAGGCGGCGGTCAGATCCTTGCAAGCATGGTCGCGCCGGGGCTTGTACTCGGGC
TGGTGCTGCCATTAATCCTGTGGGCCGACAGAAGTGCAGGTATTGGTTTTCGCTTTGCTTCATACATCAATAATGATATGGTGCTGCAGA
AGGAGCCTGCTGGGGCAGTGATATGGGGCTTCGGTACACCTGGAGCCACAGTGACCGTGACCCTGCGCCAAGGTCAGGAAACCATCATGA
AGAAAGTGACCAGTGTGAAAGCTCACTCTGATACGTGGATGGTGGTACTGGATCCTATGAAGCCTGGAGGACCTTTCGAAGTGATGGCAC
AACAGACTTTGGAGAAAATAAACTTCACCCTGAGAGTTCATGACGTCCTGTTTGGAGATGTCTGGCTCTGTAGTGGGCAGAGTAACATGC
AGATGACTGTGTTACAGATATTTAATGCTACAAGGGAGTTGTCTAACACTGCGGCATATCAGTCTGTCCGCATCCTCTCTGTCTCTCCCA
TTCAAGCAGAGCAGGAGCTGGAGGACCTTGTTGCGGTTGACTTGCAGTGGTCTAAGCCCACCTCAGAAAACTTAGGCCATGGATATTTCA
AGTACATGTCAGCAGTGTGCTGGCTCTTTGGACGTCACCTTTATGACACTCTGCAGTATCCCATCGGGCTGATCGCCTCCAGCTGGGGCG
GGACACCCATTGAAGCCTGGTCATCTGGACGGTCACTGAAAGCCTGTGGGGTCCCTAAACAAGGGTCCATTCCATACGATTCTGTAACTG
GTCCCAGTAAGCACTCTGTTCTCTGGAATGCCATGATCCATCCACTGTGCAATATGACTCTGAAAGGGGTAGTATGGTACCAGGGGGAGT
CCAATATAAATTATAACACGGATCTGTACAATTGCACATTCCCTGCACTCATCGAAGACTGGCGTGAAACCTTCCACCGTGGTTCCCAGG
GGCAGACGGAGCGTTTCTTCCCATTTGGACTTGTCCAGTTATCTTCAGATTTGTCTAAGAAGAGCTCAGACGATGGATTTCCCCAGATCC
GTTGGCATCAAACAGCAGACTTCGGCTATGTCCCCAACCCAAAGATGCCCAATACTTTCATGGCTGTAGCTATGGATCTCTGTGATAGAG
ACTCGCCTTTTGGCAGCATCCACCCTCGAGATAAACAGACTGTGGCTTATCGGCTGCATTTGGGGGCCCGTGCTCTGGCTTATGGTGAGA
AGAATTTGACCTTTGAAGGACCACTGCCTGAGAAGATAGAACTCTTGGCTCACAAGGGGCTGCTCAATCTCACATATTACCAGCAAATCC
AGGTGCAGAAAAAGGACAACAAGATATTTGAGATCTCCTGTTGCAGTGACCATCGATGCAAGTGGCTTCCAGCTTCTATGAACACCGTCT
CCACCCAGTCCCTGACCCTGGCGATCGATTCTTGTCATGGCACTGTGGTTGCTCTCCGCTATGCTTGGACCACGTGGCCTTGTGAATATA
AGCAGTGTCCCCTATACCACCCCAGTAGTGCCCTGCCAGCCCCTCCCTTCATTGCTTTCATTACAGACCAGGGTCCTGGACATCAGAGCA
ATGTTGCTAAATGACTGTTTCAGTATGATCAGAACTTAGATATAAGGATGGGTCCTTCAGATTTTAGCATTTAGGAGTTTCAATAATAAC
CATTGCTTTTAAAGGAAATTAATAGAAAGCCTCATTGAATGGCTTTCAGCTAGCACATGGCTGTTTCTATATTCTGATGAGCCCAGGCTT
ATAGGTAACTTGAAATGCTTGCTTTTTGTTCCCTAGTTGGTCTAAGGGTCTGTATTGGACTAATTCTGAACTACAGACAAATTGGACCTC
AATGTCATTTACTTCCCTCATATTAATGGGAGTGAAATGTCTAATACTTTTGCCCCTTTTTATCCAGAGTTGTGGGAATCTCAGGATTGG
AAGAGATTTTAAAGGCCACATAGGCCAGCTAGTGTTCATGTGTTCTTTATAAAATTTCTCCCATCCAAGTACTAACCAGGCCCGACCCTG
CTTAGCTTCCGAGATCAGATGAGATCAGGCGCGTTCAGGGTGATATGGCCGTAGACGTCTTTACAAAATTCCTGACAGGTGGTTACTGAA
TCTCTCTATGAACTTTCCATTCAAAACTTTCCAAGTTTTTCCTTATGTGGAACCGAAATCTTTCTTTCTCCCGTGAAACTTTACTACTAT
CAGATAATTGAAGACAGATCTCTTTGTATTCTCTTCAAGCCCAAACCAATTCTGTTCCTTCAATCTAAATAGTGGTAATATGAATGTTTA
AGAAATGAAATAAGAAACATGTGCAGGCACTTTGGAAGGTGCTAAGTGACTGCCCTAAGGAATGAAAAGCAAGGGCCAGGTGGGAGTAGC
CCAGCGAAGGCACTTGGGCTGCCAGGAACAGGAGGCGTGGGAAACTCTGGCTTAGGAAAACATGAACACAGGGGCAACAGAGGCAAACTG
TTGTTCGAGTTAAATATAAATCTCAGGCTCTTTAAAGGTAAAAGGTTTAAGGATAATCCATTTGGAAGAAGAAAAGAGTGAGGCTGAAAG
TAAAGCCACATGACAAGCATATAAAAAAAAATGCAGATGATACAAATATGAAAGAGGCCTTCAGTGTTTGTTTATTAAGAATCTTAATGC
AGTTTACTGATGGATTAAAAACAGCTAACATTGTCTGAAAATTATGTTACCTATAAGAAGTTGGAAATAAATAAAAGCATAATCACTAGT
GATGTGTATGTATTTATATCCACTTGCAAACTGTCCTTGAAGCATGTGAAAAGGAGTAAGAATACTATCTATGGGTAGCTTTCCTCCCCT
TAATGTGAAAAATGAGAACTAAAGCAAAAAGCATCACTCACTGTACATATACAATGTATTTTACGTAGTGTAAAAAATATGGTTTAGATA
GTGAATATATTAATGAAATCATATGTAAATTTATTTTTAGTGGCTGAATAATTTAAAACATTATGTGGAATTCACTATGTTTCCCCCAAT
TTAGGAACTTTTTACTGTGTGAAAATGAAATTTATAATACTCTGTAGGGTGAATGATGGTTTTTGCTTTAGTTCTACCCCTCTGTAGAGT
TCCAAGGGGTTCTGGTGTAGCTCCAAACAGCAGGAATAACTTTGTCAGTGCCAAGATTTTATTTAGTTAAAAAACAAAAAATCTACACAC
TTTACAAGGAACGTTGGCTCCCCTGAGGACTTCCTAGCATTCAACTCGTTCAGTTAACCCCTATTGCCCATGCTTTGACCTCTCATGCAT
CTGGCCCCATAGAAACCATGAACCTTGTAACAGATTGATGCCTGAGAAAAAGTCAATCTACCCGTCCACTCCTCCACTCCCAATACACAT
ACCCCCATGGGCTGTTCTAATTCGGGGGCAGCCAGAGGTAGCCAAGAACTCTAAGTCCAGATTCCTTTCACCTCCAGGAACCTAGAGTAC
ATAGTGTGAAAAATACGGTTCAGGCAATGATTATGTTAATGACGCCATGCACATTCATTTTTAGTGGCTGAGTAATTTAAAACATGATGT
GGGAATTCACTGCATTTCCCCAAATGTAAGAACTTTTTAGTTTTAAAATGAAATTTATAGTCACTGTAGAAAATTTGGACACTAAAGTAT
AAGCAAGTAAAAATCACCCCCAAATTCATCATTCAGAGAAACACTATTTTGCTGAACCATTCACTTGACTTGAGTTATATAATTTTATAC
AGTACATATTATTTTGTAATCTGTGTTTTTGACTTACTTACTTTACCAAAATAATTTTCTTATGTAAATAATAGAATATAGATTTAGAGT
GTTTCAGTTTGTGGAAGCCTCATTTTATTTAACCAATTTCCTATTAATGGACATATAGATTTTTAACAATTTTCTACTATTAAAATAATA
CTGTAATGAATATCACATGCAAACATCATACCACACTCGTCCAGTTATTTCTTAGGGTTCTTAACATGGAAGAGGATAAATATATATTTA
AAATTTAGATATCTACAGCTTAACCCTCCCAAAGGATTAAACAACTTACATTCTCACCAAGGTAGTCCTTTTTTTGCCCTCACCCTCATT
GACACTGGATGTTGTCAAATTTAAAAAAAATCCTTAACAATCTGATAGATGAAAAGATAGTTTAAGTATACTAAGGCAGTGTTTTTCAAG
GTGTTTTTGTTTTTGTTTTTGAGTTGGAGTTTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGGTCTCGGCTCACTGCAACCTCTGC
CTCCCGGGTTCAAGCGATTCTTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCGTGCCACCACGCCTGGCTAATTTTTTGTAT
TTTTATTAGAGACCGACTTAGCCAGGATGGTCTCGATCTCCTGACCTCTTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAG
GCGTGAGCCACCGTGCCCAGCTTTTCAAGTTTCTTAAATCCATGATCCATAGTAAAAACATTTTACACATATCTTCATACAAGTATATGT
ATATGTGGTATACGTACACACTATAGTTGTATATGCATTATAGCTGAAAAACCAGTTCAACCTTTCTACATGTGGTATGTTCCAAAAATT
TTAAATGTCTTTCTAAAATGAGGCTCTTTTAATACGGGTATTACTCAGGCTGTAATAGTGGGAAAATATTTGTTATATGATAAAAGCAGC
ATATATCATTTCTGTGTAAATGCCAGTATGCTCAAGCCATTTATGCAGAGAAAAAAAGAAAAACACTGCATTAACATTTTAAGCAGTCCC
CTTCCCGATTTGCTATTATACAAAGTTTGTTTCTTTTACATTGTAAAGTGTATACAACTTATAAAAAGACTATACTCAAAATCATAAAAT
ACCAGTTAACTTAGCTTCTCAGTTTACAGTGGCCAGTGTGGTGTGCTCTAAACACTGCTGCCTGATCCCTCCCTCTGCTGGTCAGATTTA
TTACTATAAAGTACCAATCCCATTTGTGTTGTCCTCAATTGGCAATTATGAATGGCAGTGCATTAACCATTCAATTCTCACCACTCCATC
CCCATTCTTCTACTTCTGGGTCCTTTTGTCCCTCCCTTTCCAGACAGCCCTTGGTAACCTGCTGCTGGGTAACTAAGGCATCCCACAGGT
AGTGTTGAGGTGTTAGGTGATAGAGTAAACCTCTACCTTAATGCTATTAACAGGGTCCAAAAATCCAGTTGCATGGAACATGGAGTTATA
TTATTACATGGCTAATGAAAAGACAGGACTAAGTCTGTTATAGAGTATGGGACTAACCCCCAATTATATGTGAATTTGTGTTATCATATG

>In-frame_ENST00000371100_ENST00000263593_TCGA-BJ-A192-01A_GNAS_chr20_57486241_-_SIAE_chr11_124543777_length(amino acids)=1044AA_start in transcript=531_stop in transcript=3665
MRGRHRVMGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNP
AFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRG
CSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSA
VRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPP
VEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDS
GAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSP
EIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRS
ESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNG
EGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVR
ACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVAS
SSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYF

--------------------------------------------------------------
>In-frame_ENST00000371102_ENST00000263593_TCGA-BJ-A192-01A_GNAS_chr20_57486241_-_SIAE_chr11_124543777_length(transcript)=9021nt_BP=3438nt
GTTATGGGCGTGCGCAACTGCCTCTACGGCAATAATATGTCAGGACAACGCGATATCCCCCCTGAAATCGGGGAACAGCCCGAGCAACCA
CCTTTGGAGGCCCCAGGGGCAGCTGCCCCCGGTGCTGGGCCTAGCCCAGCCGAAGAGATGGAGACCGAACCGCCTCACAACGAGCCCATC
CCCGTCGAGAATGATGGCGAGGCCTGTGGACCCCCAGAGGTCTCCAGACCCAACTTTCAGGTCCTCAACCCGGCATTCAGGGAAGCTGGA
GCCCATGGAAGCTACAGCCCACCTCCTGAGGAAGCAATGCCCTTCGAGGCTGAACAGCCCAGCTTGGGAGGCTTCTGGCCTACACTGGAG
CAGCCTGGATTCCCCAGTGGGGTCCATGCAGGCCTTGAGGCCTTCGGCCCAGCACTCATGGAGCCCGGAGCCTTCAGTGGTGCCAGACCA
GGCCTGGGAGGATACAGCCCTCCACCAGAAGAAGCTATGCCCTTTGAGTTTGACCAGCCTGCCCAGAGAGGCTGCAGTCAACTTCTCTTA
CAGGTCCCAGACCTTGCTCCAGGAGGCCCAGGTGCTGCAGGGGTCCCCGGAGCTCCTCCCGAGGAGCCCCAAGCCCTCAGGCCTGCAAAG
GCTGGCTCCAGAGGAGGCTACAGCCCTCCCCCTGAGGAGACTATGCCATTTGAGCTTGATGGAGAAGGATTTGGGGACGACAGCCCACCC
CCGGGGCTTTCCCGAGTTATCGCACAAGTCGACGGCAGCAGCCAGTTCGCGGCAGTCGCGGCCTCGAGTGCGGTCCGCCTCACTCCCGCC
GCGAACGCGCCTCCCCTCTGGGTCCCAGGCGCCATCGGCAGCCCATCCCAAGAGGCTGTCAGACCTCCTTCTAACTTCACGGGCAGCAGC
CCCTGGATGGAGATCTCCGGACCCCCGTTCGAGATTGGCAGCGCCCCCGCTGGGGTCGACGACACTCCCGTCAACATGGACAGCCCCCCA
ATCGCGCTTGACGGCCCGCCCATCAAGGTCTCCGGAGCCCCAGATAAGAGAGAGCGAGCAGAGAGACCCCCAGTTGAGGAGGAAGCAGCA
GAGATGGAAGGAGCCGCTGATGCCGCGGAGGGAGGAAAAGTACCCTCTCCGGGGTACGGATCCCCTGCCGCCGGGGCAGCCTCAGCGGAT
ACCGCTGCCAGGGCAGCCCCTGCAGCCCCAGCCGATCCTGACTCCGGGGCAACCCCAGAAGATCCCGACTCCGGGACAGCACCAGCCGAT
CCTGACTCCGGGGCATTCGCAGCCGATCCCGACTCCGGGGCAGCCCCTGCCGCCCCAGCCGATCCCGACTCCGGGGCGGCCCCTGACGCC
CCAGCCGATCCCGACTCCGGGGCGGCCCCTGACGCCCCAGCCGATCCAGATGCCGGGGCGGCCCCTGAGGCTCCCGCCGCCCCTGCGGCT
GCTGAGACCCGGGCAGCCCATGTCGCCCCAGCTGCGCCAGACGCAGGGGCTCCCACTGCCCCAGCCGCTTCTGCCACCCGGGCAGCCCAA
GTCCGCCGGGCGGCCTCTGCAGCCCCTGCCTCCGGGGCCAGACGCAAGATCCATCTCAGACCCCCCAGCCCCGAGATCCAGGCTGCCGAT
CCGCCTACTCCGCGGCCTACTCGCGCGTCTGCCTGGCGGGGCAAGTCCGAGAGCAGCCGCGGCCGCCGCGTGTACTACGATGAAGGGGTG
GCCAGCAGCGACGATGACTCCAGCGGAGACGAGTCCGACGATGGGACCTCCGGATGCCTCCGCTGGTTTCAGCATCGGCGAAATCGCCGC
CGCCGAAAGCCCCAGCGCAACTTACTCCGCAACTTTCTCGTGCAAGCCTTCGGGGGCTGCTTCGGTCGATCTGAGAGTCCCCAGCCCAAA
GCCTCGCGCTCTCTCAAGGTCAAGAAGGTACCCCTGGCGGAGAAGCGCAGACAGATGCGCAAAGAAGCCCTGGAGAAGCGGGCCCAGAAG
CGCGCAGAGAAGAAACGCAGTAAGCTCATCGACAAACAACTCCAGGACGAAAAGATGGGCTACATGTGTACGCACCGCCTGCTGCTTCTA
GGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGACAGTGAGAAGGCAACC
AAAGTGCAGGACATCAAAAACAACCTGAAAGAGGCGATTGAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCGTGGAGCTGGCC
AACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGTGTGATGAACGTGCCTGACTTTGACTTCCCTCCCGAATTCTATGAGCATGCC
AAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCTGCTACGAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGTACTTCCTGGAC
AAGATCGACGTGATCAAGCAGGCTGACTATGTGCCGAGCGATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGGAATCTTTGAGACC
AAGTTCCAGGTGGACAAAGTCAACTTCCACATGTTTGACGTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGTGCTTCAACGAT
GTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTACAACATGGTCATCCGGGAGGACAACCAGACCAACCGCCTGCAGGAGGCTCTG
AACCTCTTCAAGAGCATCTGGAACAACAGATGGCTGCGCACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGCTCGCTGAGAAA
GTCCTTGCTGGGAAATCGAAGATTGAGGACTACTTTCCAGAATTTGCTCGCTACACTACTCCTGAGGATGCTACTCCCGAGCCCGGAGAG
GACCCACGCGTGACCCGGGCCAAGTACTTCATTCGAGATGAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTCACTACTGCTAC
CCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGCCGTGTGTTCAACGACTGCCGTGACATCATTCAGCGCATGCACCTTCGTCAG
TACGAGCTGCTCTAAGAAGGGAACCCCCAAATTTAATTAAAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAATTGTACAAGCAGTTA
ATCACCCACCATAGGGCATGATTAACAAAGCAACCTTTCCCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCTTCAGCTTGCTTAG
ATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTACAGAAAAAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAGTAAAAATAAATAA
AACAGCAGCAGCAAACAAATAAAATGAAATAAAAGAAACAAATGAAATAAATATTGTGTTGTGCAGCATTAAAAAAAATCAAAATAAAAA
TTAAATGTGAGCAAAGAAAAAAAAAAAAAAAAACTACGGCGGCCGAGAAGGGGCGAGTACAGCCCAGTCCTGAGGTCGCGGGAGGCTGCG
AGGACTGCAAAAGGGTGGAGTCGGCCTCGCCCCCGCCCAGGCCCCGCCCCTGCCGGGAACCCACTTTCCCAGTCCTAGGCGGCGGTCAGA
TCCTTGCAAGCATGGTCGCGCCGGGGCTTGTACTCGGGCTGGTGCTGCCATTAATCCTGTGGGCCGACAGAAGTGCAGGTATTGGTTTTC
GCTTTGCTTCATACATCAATAATGATATGGTGCTGCAGAAGGAGCCTGCTGGGGCAGTGATATGGGGCTTCGGTACACCTGGAGCCACAG
TGACCGTGACCCTGCGCCAAGGTCAGGAAACCATCATGAAGAAAGTGACCAGTGTGAAAGCTCACTCTGATACGTGGATGGTGGTACTGG
ATCCTATGAAGCCTGGAGGACCTTTCGAAGTGATGGCACAACAGACTTTGGAGAAAATAAACTTCACCCTGAGAGTTCATGACGTCCTGT
TTGGAGATGTCTGGCTCTGTAGTGGGCAGAGTAACATGCAGATGACTGTGTTACAGATATTTAATGCTACAAGGGAGTTGTCTAACACTG
CGGCATATCAGTCTGTCCGCATCCTCTCTGTCTCTCCCATTCAAGCAGAGCAGGAGCTGGAGGACCTTGTTGCGGTTGACTTGCAGTGGT
CTAAGCCCACCTCAGAAAACTTAGGCCATGGATATTTCAAGTACATGTCAGCAGTGTGCTGGCTCTTTGGACGTCACCTTTATGACACTC
TGCAGTATCCCATCGGGCTGATCGCCTCCAGCTGGGGCGGGACACCCATTGAAGCCTGGTCATCTGGACGGTCACTGAAAGCCTGTGGGG
TCCCTAAACAAGGGTCCATTCCATACGATTCTGTAACTGGTCCCAGTAAGCACTCTGTTCTCTGGAATGCCATGATCCATCCACTGTGCA
ATATGACTCTGAAAGGGGTAGTATGGTACCAGGGGGAGTCCAATATAAATTATAACACGGATCTGTACAATTGCACATTCCCTGCACTCA
TCGAAGACTGGCGTGAAACCTTCCACCGTGGTTCCCAGGGGCAGACGGAGCGTTTCTTCCCATTTGGACTTGTCCAGTTATCTTCAGATT
TGTCTAAGAAGAGCTCAGACGATGGATTTCCCCAGATCCGTTGGCATCAAACAGCAGACTTCGGCTATGTCCCCAACCCAAAGATGCCCA
ATACTTTCATGGCTGTAGCTATGGATCTCTGTGATAGAGACTCGCCTTTTGGCAGCATCCACCCTCGAGATAAACAGACTGTGGCTTATC
GGCTGCATTTGGGGGCCCGTGCTCTGGCTTATGGTGAGAAGAATTTGACCTTTGAAGGACCACTGCCTGAGAAGATAGAACTCTTGGCTC
ACAAGGGGCTGCTCAATCTCACATATTACCAGCAAATCCAGGTGCAGAAAAAGGACAACAAGATATTTGAGATCTCCTGTTGCAGTGACC
ATCGATGCAAGTGGCTTCCAGCTTCTATGAACACCGTCTCCACCCAGTCCCTGACCCTGGCGATCGATTCTTGTCATGGCACTGTGGTTG
CTCTCCGCTATGCTTGGACCACGTGGCCTTGTGAATATAAGCAGTGTCCCCTATACCACCCCAGTAGTGCCCTGCCAGCCCCTCCCTTCA
TTGCTTTCATTACAGACCAGGGTCCTGGACATCAGAGCAATGTTGCTAAATGACTGTTTCAGTATGATCAGAACTTAGATATAAGGATGG
GTCCTTCAGATTTTAGCATTTAGGAGTTTCAATAATAACCATTGCTTTTAAAGGAAATTAATAGAAAGCCTCATTGAATGGCTTTCAGCT
AGCACATGGCTGTTTCTATATTCTGATGAGCCCAGGCTTATAGGTAACTTGAAATGCTTGCTTTTTGTTCCCTAGTTGGTCTAAGGGTCT
GTATTGGACTAATTCTGAACTACAGACAAATTGGACCTCAATGTCATTTACTTCCCTCATATTAATGGGAGTGAAATGTCTAATACTTTT
GCCCCTTTTTATCCAGAGTTGTGGGAATCTCAGGATTGGAAGAGATTTTAAAGGCCACATAGGCCAGCTAGTGTTCATGTGTTCTTTATA
AAATTTCTCCCATCCAAGTACTAACCAGGCCCGACCCTGCTTAGCTTCCGAGATCAGATGAGATCAGGCGCGTTCAGGGTGATATGGCCG
TAGACGTCTTTACAAAATTCCTGACAGGTGGTTACTGAATCTCTCTATGAACTTTCCATTCAAAACTTTCCAAGTTTTTCCTTATGTGGA
ACCGAAATCTTTCTTTCTCCCGTGAAACTTTACTACTATCAGATAATTGAAGACAGATCTCTTTGTATTCTCTTCAAGCCCAAACCAATT
CTGTTCCTTCAATCTAAATAGTGGTAATATGAATGTTTAAGAAATGAAATAAGAAACATGTGCAGGCACTTTGGAAGGTGCTAAGTGACT
GCCCTAAGGAATGAAAAGCAAGGGCCAGGTGGGAGTAGCCCAGCGAAGGCACTTGGGCTGCCAGGAACAGGAGGCGTGGGAAACTCTGGC
TTAGGAAAACATGAACACAGGGGCAACAGAGGCAAACTGTTGTTCGAGTTAAATATAAATCTCAGGCTCTTTAAAGGTAAAAGGTTTAAG
GATAATCCATTTGGAAGAAGAAAAGAGTGAGGCTGAAAGTAAAGCCACATGACAAGCATATAAAAAAAAATGCAGATGATACAAATATGA
AAGAGGCCTTCAGTGTTTGTTTATTAAGAATCTTAATGCAGTTTACTGATGGATTAAAAACAGCTAACATTGTCTGAAAATTATGTTACC
TATAAGAAGTTGGAAATAAATAAAAGCATAATCACTAGTGATGTGTATGTATTTATATCCACTTGCAAACTGTCCTTGAAGCATGTGAAA
AGGAGTAAGAATACTATCTATGGGTAGCTTTCCTCCCCTTAATGTGAAAAATGAGAACTAAAGCAAAAAGCATCACTCACTGTACATATA
CAATGTATTTTACGTAGTGTAAAAAATATGGTTTAGATAGTGAATATATTAATGAAATCATATGTAAATTTATTTTTAGTGGCTGAATAA
TTTAAAACATTATGTGGAATTCACTATGTTTCCCCCAATTTAGGAACTTTTTACTGTGTGAAAATGAAATTTATAATACTCTGTAGGGTG
AATGATGGTTTTTGCTTTAGTTCTACCCCTCTGTAGAGTTCCAAGGGGTTCTGGTGTAGCTCCAAACAGCAGGAATAACTTTGTCAGTGC
CAAGATTTTATTTAGTTAAAAAACAAAAAATCTACACACTTTACAAGGAACGTTGGCTCCCCTGAGGACTTCCTAGCATTCAACTCGTTC
AGTTAACCCCTATTGCCCATGCTTTGACCTCTCATGCATCTGGCCCCATAGAAACCATGAACCTTGTAACAGATTGATGCCTGAGAAAAA
GTCAATCTACCCGTCCACTCCTCCACTCCCAATACACATACCCCCATGGGCTGTTCTAATTCGGGGGCAGCCAGAGGTAGCCAAGAACTC
TAAGTCCAGATTCCTTTCACCTCCAGGAACCTAGAGTACATAGTGTGAAAAATACGGTTCAGGCAATGATTATGTTAATGACGCCATGCA
CATTCATTTTTAGTGGCTGAGTAATTTAAAACATGATGTGGGAATTCACTGCATTTCCCCAAATGTAAGAACTTTTTAGTTTTAAAATGA
AATTTATAGTCACTGTAGAAAATTTGGACACTAAAGTATAAGCAAGTAAAAATCACCCCCAAATTCATCATTCAGAGAAACACTATTTTG
CTGAACCATTCACTTGACTTGAGTTATATAATTTTATACAGTACATATTATTTTGTAATCTGTGTTTTTGACTTACTTACTTTACCAAAA
TAATTTTCTTATGTAAATAATAGAATATAGATTTAGAGTGTTTCAGTTTGTGGAAGCCTCATTTTATTTAACCAATTTCCTATTAATGGA
CATATAGATTTTTAACAATTTTCTACTATTAAAATAATACTGTAATGAATATCACATGCAAACATCATACCACACTCGTCCAGTTATTTC
TTAGGGTTCTTAACATGGAAGAGGATAAATATATATTTAAAATTTAGATATCTACAGCTTAACCCTCCCAAAGGATTAAACAACTTACAT
TCTCACCAAGGTAGTCCTTTTTTTGCCCTCACCCTCATTGACACTGGATGTTGTCAAATTTAAAAAAAATCCTTAACAATCTGATAGATG
AAAAGATAGTTTAAGTATACTAAGGCAGTGTTTTTCAAGGTGTTTTTGTTTTTGTTTTTGAGTTGGAGTTTTGCTCTGTTGCCCAGGCTG
GAGTGCAGTGGCGCGGTCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTTCCTGCCTCAGCCTCCCGAGTAGCTGGGAC
TACAGGCGCGTGCCACCACGCCTGGCTAATTTTTTGTATTTTTATTAGAGACCGACTTAGCCAGGATGGTCTCGATCTCCTGACCTCTTG
ATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCAGCTTTTCAAGTTTCTTAAATCCATGATCCATA
GTAAAAACATTTTACACATATCTTCATACAAGTATATGTATATGTGGTATACGTACACACTATAGTTGTATATGCATTATAGCTGAAAAA
CCAGTTCAACCTTTCTACATGTGGTATGTTCCAAAAATTTTAAATGTCTTTCTAAAATGAGGCTCTTTTAATACGGGTATTACTCAGGCT
GTAATAGTGGGAAAATATTTGTTATATGATAAAAGCAGCATATATCATTTCTGTGTAAATGCCAGTATGCTCAAGCCATTTATGCAGAGA
AAAAAAGAAAAACACTGCATTAACATTTTAAGCAGTCCCCTTCCCGATTTGCTATTATACAAAGTTTGTTTCTTTTACATTGTAAAGTGT
ATACAACTTATAAAAAGACTATACTCAAAATCATAAAATACCAGTTAACTTAGCTTCTCAGTTTACAGTGGCCAGTGTGGTGTGCTCTAA
ACACTGCTGCCTGATCCCTCCCTCTGCTGGTCAGATTTATTACTATAAAGTACCAATCCCATTTGTGTTGTCCTCAATTGGCAATTATGA
ATGGCAGTGCATTAACCATTCAATTCTCACCACTCCATCCCCATTCTTCTACTTCTGGGTCCTTTTGTCCCTCCCTTTCCAGACAGCCCT
TGGTAACCTGCTGCTGGGTAACTAAGGCATCCCACAGGTAGTGTTGAGGTGTTAGGTGATAGAGTAAACCTCTACCTTAATGCTATTAAC
AGGGTCCAAAAATCCAGTTGCATGGAACATGGAGTTATATTATTACATGGCTAATGAAAAGACAGGACTAAGTCTGTTATAGAGTATGGG
ACTAACCCCCAATTATATGTGAATTTGTGTTATCATATGGTTTCAGTGTACTGAGCTAAAAAGCACATTATCTGAGGTGCAATACAAAGG

>In-frame_ENST00000371102_ENST00000263593_TCGA-BJ-A192-01A_GNAS_chr20_57486241_-_SIAE_chr11_124543777_length(amino acids)=1023AA_start in transcript=3_stop in transcript=3074
MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNPAFREAGA
HGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQ
VPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSAVRLTPAA
NAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE
MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAP
ADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADP
PTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRSESPQPKA
SRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGDSEKATK
VQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDK
IDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALN
LFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYP

--------------------------------------------------------------
>In-frame_ENST00000371095_ENST00000263593_TCGA-BJ-A192-01A_GNAS_chr20_57486241_-_SIAE_chr11_124543777_length(transcript)=7514nt_BP=1931nt
CTCGCCGCCGCCGCCTCCTCCTCCCCCCGCCTCCCCCCGCCCGCCGCGGCGCTTTTGGCTCGGGGCGGCGGCGGGGGCCCGGCCGAGGCA
ATAAGAGCGGCGGCGGCGGCAGCGGCGGCAGCAGCTCCCGCAGCTCCTGCTCTGGTCCGCCTCGGCCCGGCGGCGGCCATCAGCCCCCTC
GGCCTCGGCTCGAGGGGCGGGGAGCTGCGCGCGCCCCTCGGTCCGACCGACACCCTCCCCTTCCCGCCCGTCCGCGCGCCCCGCGGCCCG
CGGCCCGCAGTCCGCCCCGCGCGCTCCTTGCCGAGGAGCCGAGCCCGCGCCCGGCCCGCCCGCCCGGCGCTGCCCCGGCCCTCCCGGCCC
GCGTGAGGCCGCCCGCGCCCGCCGCCGCCGCAGCCCGGCCGCGCCCCGCCGCCGCCGCCGCCGCCATGGGCTGCCTCGGGAACAGTAAGA
CCGAGGACCAGCGCAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGG
CCACGCACCGCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTA
ATGGAGACAGTGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGGCGATTGAAACCATTGTGGCCGCCATGAGCAACC
TGGTGCCCCCCGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGTGTGATGAACGTGCCTGACTTTGACTTCC
CTCCCGAATTCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCTGCTACGAACGCTCCAACGAGTACCAGCTGATTG
ACTGTGCCCAGTACTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGACTATGTGCCGAGCGATCAGGACCTGCTTCGCTGCCGTGTCC
TGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGTTTGACGTGGGTGGCCAGCGCGATGAACGCCGCA
AGTGGATCCAGTGCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTACAACATGGTCATCCGGGAGGACAACCAGA
CCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGCTGCGCACCATCTCTGTGATCCTGTTCCTCAACA
AGCAAGATCTGCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGAGGACTACTTTCCAGAATTTGCTCGCTACACTACTCCTGAGG
ATGCTACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTCGAGATGAGTTTCTGAGGATCAGCACTGCCAGTG
GAGATGGGCGTCACTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGCCGTGTGTTCAACGACTGCCGTGACATCA
TTCAGCGCATGCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTTAATTAAAGCCTTAAGCACAATTAATTAAAAGTG
AAACGTAATTGTACAAGCAGTTAATCACCCACCATAGGGCATGATTAACAAAGCAACCTTTCCCTTCCCCCGAGTGATTTTGCGAAACCC
CCTTTTCCCTTCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTACAGAAAAAGGAAAAAAGGCCACAAAAGTTCCCTC
TCACTTTCAGTAAAAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAAGAAACAAATGAAATAAATATTGTGTTGTGCAGC
ATTAAAAAAAATCAAAATAAAAATTAAATGTGAGCAAAGAAAAAAAAAAAAAAAAACTACGGCGGCCGAGAAGGGGCGAGTACAGCCCAG
TCCTGAGGTCGCGGGAGGCTGCGAGGACTGCAAAAGGGTGGAGTCGGCCTCGCCCCCGCCCAGGCCCCGCCCCTGCCGGGAACCCACTTT
CCCAGTCCTAGGCGGCGGTCAGATCCTTGCAAGCATGGTCGCGCCGGGGCTTGTACTCGGGCTGGTGCTGCCATTAATCCTGTGGGCCGA
CAGAAGTGCAGGTATTGGTTTTCGCTTTGCTTCATACATCAATAATGATATGGTGCTGCAGAAGGAGCCTGCTGGGGCAGTGATATGGGG
CTTCGGTACACCTGGAGCCACAGTGACCGTGACCCTGCGCCAAGGTCAGGAAACCATCATGAAGAAAGTGACCAGTGTGAAAGCTCACTC
TGATACGTGGATGGTGGTACTGGATCCTATGAAGCCTGGAGGACCTTTCGAAGTGATGGCACAACAGACTTTGGAGAAAATAAACTTCAC
CCTGAGAGTTCATGACGTCCTGTTTGGAGATGTCTGGCTCTGTAGTGGGCAGAGTAACATGCAGATGACTGTGTTACAGATATTTAATGC
TACAAGGGAGTTGTCTAACACTGCGGCATATCAGTCTGTCCGCATCCTCTCTGTCTCTCCCATTCAAGCAGAGCAGGAGCTGGAGGACCT
TGTTGCGGTTGACTTGCAGTGGTCTAAGCCCACCTCAGAAAACTTAGGCCATGGATATTTCAAGTACATGTCAGCAGTGTGCTGGCTCTT
TGGACGTCACCTTTATGACACTCTGCAGTATCCCATCGGGCTGATCGCCTCCAGCTGGGGCGGGACACCCATTGAAGCCTGGTCATCTGG
ACGGTCACTGAAAGCCTGTGGGGTCCCTAAACAAGGGTCCATTCCATACGATTCTGTAACTGGTCCCAGTAAGCACTCTGTTCTCTGGAA
TGCCATGATCCATCCACTGTGCAATATGACTCTGAAAGGGGTAGTATGGTACCAGGGGGAGTCCAATATAAATTATAACACGGATCTGTA
CAATTGCACATTCCCTGCACTCATCGAAGACTGGCGTGAAACCTTCCACCGTGGTTCCCAGGGGCAGACGGAGCGTTTCTTCCCATTTGG
ACTTGTCCAGTTATCTTCAGATTTGTCTAAGAAGAGCTCAGACGATGGATTTCCCCAGATCCGTTGGCATCAAACAGCAGACTTCGGCTA
TGTCCCCAACCCAAAGATGCCCAATACTTTCATGGCTGTAGCTATGGATCTCTGTGATAGAGACTCGCCTTTTGGCAGCATCCACCCTCG
AGATAAACAGACTGTGGCTTATCGGCTGCATTTGGGGGCCCGTGCTCTGGCTTATGGTGAGAAGAATTTGACCTTTGAAGGACCACTGCC
TGAGAAGATAGAACTCTTGGCTCACAAGGGGCTGCTCAATCTCACATATTACCAGCAAATCCAGGTGCAGAAAAAGGACAACAAGATATT
TGAGATCTCCTGTTGCAGTGACCATCGATGCAAGTGGCTTCCAGCTTCTATGAACACCGTCTCCACCCAGTCCCTGACCCTGGCGATCGA
TTCTTGTCATGGCACTGTGGTTGCTCTCCGCTATGCTTGGACCACGTGGCCTTGTGAATATAAGCAGTGTCCCCTATACCACCCCAGTAG
TGCCCTGCCAGCCCCTCCCTTCATTGCTTTCATTACAGACCAGGGTCCTGGACATCAGAGCAATGTTGCTAAATGACTGTTTCAGTATGA
TCAGAACTTAGATATAAGGATGGGTCCTTCAGATTTTAGCATTTAGGAGTTTCAATAATAACCATTGCTTTTAAAGGAAATTAATAGAAA
GCCTCATTGAATGGCTTTCAGCTAGCACATGGCTGTTTCTATATTCTGATGAGCCCAGGCTTATAGGTAACTTGAAATGCTTGCTTTTTG
TTCCCTAGTTGGTCTAAGGGTCTGTATTGGACTAATTCTGAACTACAGACAAATTGGACCTCAATGTCATTTACTTCCCTCATATTAATG
GGAGTGAAATGTCTAATACTTTTGCCCCTTTTTATCCAGAGTTGTGGGAATCTCAGGATTGGAAGAGATTTTAAAGGCCACATAGGCCAG
CTAGTGTTCATGTGTTCTTTATAAAATTTCTCCCATCCAAGTACTAACCAGGCCCGACCCTGCTTAGCTTCCGAGATCAGATGAGATCAG
GCGCGTTCAGGGTGATATGGCCGTAGACGTCTTTACAAAATTCCTGACAGGTGGTTACTGAATCTCTCTATGAACTTTCCATTCAAAACT
TTCCAAGTTTTTCCTTATGTGGAACCGAAATCTTTCTTTCTCCCGTGAAACTTTACTACTATCAGATAATTGAAGACAGATCTCTTTGTA
TTCTCTTCAAGCCCAAACCAATTCTGTTCCTTCAATCTAAATAGTGGTAATATGAATGTTTAAGAAATGAAATAAGAAACATGTGCAGGC
ACTTTGGAAGGTGCTAAGTGACTGCCCTAAGGAATGAAAAGCAAGGGCCAGGTGGGAGTAGCCCAGCGAAGGCACTTGGGCTGCCAGGAA
CAGGAGGCGTGGGAAACTCTGGCTTAGGAAAACATGAACACAGGGGCAACAGAGGCAAACTGTTGTTCGAGTTAAATATAAATCTCAGGC
TCTTTAAAGGTAAAAGGTTTAAGGATAATCCATTTGGAAGAAGAAAAGAGTGAGGCTGAAAGTAAAGCCACATGACAAGCATATAAAAAA
AAATGCAGATGATACAAATATGAAAGAGGCCTTCAGTGTTTGTTTATTAAGAATCTTAATGCAGTTTACTGATGGATTAAAAACAGCTAA
CATTGTCTGAAAATTATGTTACCTATAAGAAGTTGGAAATAAATAAAAGCATAATCACTAGTGATGTGTATGTATTTATATCCACTTGCA
AACTGTCCTTGAAGCATGTGAAAAGGAGTAAGAATACTATCTATGGGTAGCTTTCCTCCCCTTAATGTGAAAAATGAGAACTAAAGCAAA
AAGCATCACTCACTGTACATATACAATGTATTTTACGTAGTGTAAAAAATATGGTTTAGATAGTGAATATATTAATGAAATCATATGTAA
ATTTATTTTTAGTGGCTGAATAATTTAAAACATTATGTGGAATTCACTATGTTTCCCCCAATTTAGGAACTTTTTACTGTGTGAAAATGA
AATTTATAATACTCTGTAGGGTGAATGATGGTTTTTGCTTTAGTTCTACCCCTCTGTAGAGTTCCAAGGGGTTCTGGTGTAGCTCCAAAC
AGCAGGAATAACTTTGTCAGTGCCAAGATTTTATTTAGTTAAAAAACAAAAAATCTACACACTTTACAAGGAACGTTGGCTCCCCTGAGG
ACTTCCTAGCATTCAACTCGTTCAGTTAACCCCTATTGCCCATGCTTTGACCTCTCATGCATCTGGCCCCATAGAAACCATGAACCTTGT
AACAGATTGATGCCTGAGAAAAAGTCAATCTACCCGTCCACTCCTCCACTCCCAATACACATACCCCCATGGGCTGTTCTAATTCGGGGG
CAGCCAGAGGTAGCCAAGAACTCTAAGTCCAGATTCCTTTCACCTCCAGGAACCTAGAGTACATAGTGTGAAAAATACGGTTCAGGCAAT
GATTATGTTAATGACGCCATGCACATTCATTTTTAGTGGCTGAGTAATTTAAAACATGATGTGGGAATTCACTGCATTTCCCCAAATGTA
AGAACTTTTTAGTTTTAAAATGAAATTTATAGTCACTGTAGAAAATTTGGACACTAAAGTATAAGCAAGTAAAAATCACCCCCAAATTCA
TCATTCAGAGAAACACTATTTTGCTGAACCATTCACTTGACTTGAGTTATATAATTTTATACAGTACATATTATTTTGTAATCTGTGTTT
TTGACTTACTTACTTTACCAAAATAATTTTCTTATGTAAATAATAGAATATAGATTTAGAGTGTTTCAGTTTGTGGAAGCCTCATTTTAT
TTAACCAATTTCCTATTAATGGACATATAGATTTTTAACAATTTTCTACTATTAAAATAATACTGTAATGAATATCACATGCAAACATCA
TACCACACTCGTCCAGTTATTTCTTAGGGTTCTTAACATGGAAGAGGATAAATATATATTTAAAATTTAGATATCTACAGCTTAACCCTC
CCAAAGGATTAAACAACTTACATTCTCACCAAGGTAGTCCTTTTTTTGCCCTCACCCTCATTGACACTGGATGTTGTCAAATTTAAAAAA
AATCCTTAACAATCTGATAGATGAAAAGATAGTTTAAGTATACTAAGGCAGTGTTTTTCAAGGTGTTTTTGTTTTTGTTTTTGAGTTGGA
GTTTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGGTCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTTCCTGCC
TCAGCCTCCCGAGTAGCTGGGACTACAGGCGCGTGCCACCACGCCTGGCTAATTTTTTGTATTTTTATTAGAGACCGACTTAGCCAGGAT
GGTCTCGATCTCCTGACCTCTTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCAGCTTTTCAA
GTTTCTTAAATCCATGATCCATAGTAAAAACATTTTACACATATCTTCATACAAGTATATGTATATGTGGTATACGTACACACTATAGTT
GTATATGCATTATAGCTGAAAAACCAGTTCAACCTTTCTACATGTGGTATGTTCCAAAAATTTTAAATGTCTTTCTAAAATGAGGCTCTT
TTAATACGGGTATTACTCAGGCTGTAATAGTGGGAAAATATTTGTTATATGATAAAAGCAGCATATATCATTTCTGTGTAAATGCCAGTA
TGCTCAAGCCATTTATGCAGAGAAAAAAAGAAAAACACTGCATTAACATTTTAAGCAGTCCCCTTCCCGATTTGCTATTATACAAAGTTT
GTTTCTTTTACATTGTAAAGTGTATACAACTTATAAAAAGACTATACTCAAAATCATAAAATACCAGTTAACTTAGCTTCTCAGTTTACA
GTGGCCAGTGTGGTGTGCTCTAAACACTGCTGCCTGATCCCTCCCTCTGCTGGTCAGATTTATTACTATAAAGTACCAATCCCATTTGTG
TTGTCCTCAATTGGCAATTATGAATGGCAGTGCATTAACCATTCAATTCTCACCACTCCATCCCCATTCTTCTACTTCTGGGTCCTTTTG
TCCCTCCCTTTCCAGACAGCCCTTGGTAACCTGCTGCTGGGTAACTAAGGCATCCCACAGGTAGTGTTGAGGTGTTAGGTGATAGAGTAA
ACCTCTACCTTAATGCTATTAACAGGGTCCAAAAATCCAGTTGCATGGAACATGGAGTTATATTATTACATGGCTAATGAAAAGACAGGA
CTAAGTCTGTTATAGAGTATGGGACTAACCCCCAATTATATGTGAATTTGTGTTATCATATGGTTTCAGTGTACTGAGCTAAAAAGCACA

>In-frame_ENST00000371095_ENST00000263593_TCGA-BJ-A192-01A_GNAS_chr20_57486241_-_SIAE_chr11_124543777_length(amino acids)=599AA_start in transcript=1876_stop in transcript=3675
MCCAALKKIKIKIKCEQRKKKKKTTAAEKGRVQPSPEVAGGCEDCKRVESASPPPRPRPCREPTFPVLGGGQILASMVAPGLVLGLVLPL
ILWADRSAGIGFRFASYINNDMVLQKEPAGAVIWGFGTPGATVTVTLRQGQETIMKKVTSVKAHSDTWMVVLDPMKPGGPFEVMAQQTLE
KINFTLRVHDVLFGDVWLCSGQSNMQMTVLQIFNATRELSNTAAYQSVRILSVSPIQAEQELEDLVAVDLQWSKPTSENLGHGYFKYMSA
VCWLFGRHLYDTLQYPIGLIASSWGGTPIEAWSSGRSLKACGVPKQGSIPYDSVTGPSKHSVLWNAMIHPLCNMTLKGVVWYQGESNINY
NTDLYNCTFPALIEDWRETFHRGSQGQTERFFPFGLVQLSSDLSKKSSDDGFPQIRWHQTADFGYVPNPKMPNTFMAVAMDLCDRDSPFG
SIHPRDKQTVAYRLHLGARALAYGEKNLTFEGPLPEKIELLAHKGLLNLTYYQQIQVQKKDNKIFEISCCSDHRCKWLPASMNTVSTQSL

--------------------------------------------------------------
>In-frame_ENST00000371085_ENST00000263593_TCGA-BJ-A192-01A_GNAS_chr20_57486241_-_SIAE_chr11_124543777_length(transcript)=7555nt_BP=1972nt
TCGCCGCCGCCGCCTCCTCCTCCCCCCGCCTCCCCCCGCCCGCCGCGGCGCTTTTGGCTCGGGGCGGCGGCGGGGGCCCGGCCGAGGCAA
TAAGAGCGGCGGCGGCGGCAGCGGCGGCAGCAGCTCCCGCAGCTCCTGCTCTGGTCCGCCTCGGCCCGGCGGCGGCCATCAGCCCCCTCG
GCCTCGGCTCGAGGGGCGGGGAGCTGCGCGCGCCCCTCGGTCCGACCGACACCCTCCCCTTCCCGCCCGTCCGCGCGCCCCGCGGCCCGC
GGCCCGCAGTCCGCCCCGCGCGCTCCTTGCCGAGGAGCCGAGCCCGCGCCCGGCCCGCCCGCCCGGCGCTGCCCCGGCCCTCCCGGCCCG
CGTGAGGCCGCCCGCGCCCGCCGCCGCCGCAGCCCGGCCGCGCCCCGCCGCCGCCGCCGCCGCCATGGGCTGCCTCGGGAACAGTAAGAC
CGAGGACCAGCGCAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGGC
CACGCACCGCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAA
TGGAGAGGGCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGTGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCT
GAAAGAGGCGATTGAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGA
CTACATCCTGAGTGTGATGAACGTGCCTGACTTTGACTTCCCTCCCGAATTCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGT
GCGTGCCTGCTACGAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGTACTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGA
CTATGTGCCGAGCGATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTT
CCACATGTTTGACGTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGTGCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGC
CAGCAGCAGCTACAACATGGTCATCCGGGAGGACAACCAGACCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAA
CAGATGGCTGCGCACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGA
GGACTACTTTCCAGAATTTGCTCGCTACACTACTCCTGAGGATGCTACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTA
CTTCATTCGAGATGAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTCACTACTGCTACCCTCATTTCACCTGCGCTGTGGACAC
TGAGAACATCCGCCGTGTGTTCAACGACTGCCGTGACATCATTCAGCGCATGCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCC
CCAAATTTAATTAAAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAATTGTACAAGCAGTTAATCACCCACCATAGGGCATGATTAAC
AAAGCAACCTTTCCCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCTTCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGG
CGGCCTACAGAAAAAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAGTAAAAATAAATAAAACAGCAGCAGCAAACAAATAAAATG
AAATAAAAGAAACAAATGAAATAAATATTGTGTTGTGCAGCATTAAAAAAAATCAAAATAAAAATTAAATGTGAGCAAAGAAAAAAAAAA
AAAAAAACTACGGCGGCCGAGAAGGGGCGAGTACAGCCCAGTCCTGAGGTCGCGGGAGGCTGCGAGGACTGCAAAAGGGTGGAGTCGGCC
TCGCCCCCGCCCAGGCCCCGCCCCTGCCGGGAACCCACTTTCCCAGTCCTAGGCGGCGGTCAGATCCTTGCAAGCATGGTCGCGCCGGGG
CTTGTACTCGGGCTGGTGCTGCCATTAATCCTGTGGGCCGACAGAAGTGCAGGTATTGGTTTTCGCTTTGCTTCATACATCAATAATGAT
ATGGTGCTGCAGAAGGAGCCTGCTGGGGCAGTGATATGGGGCTTCGGTACACCTGGAGCCACAGTGACCGTGACCCTGCGCCAAGGTCAG
GAAACCATCATGAAGAAAGTGACCAGTGTGAAAGCTCACTCTGATACGTGGATGGTGGTACTGGATCCTATGAAGCCTGGAGGACCTTTC
GAAGTGATGGCACAACAGACTTTGGAGAAAATAAACTTCACCCTGAGAGTTCATGACGTCCTGTTTGGAGATGTCTGGCTCTGTAGTGGG
CAGAGTAACATGCAGATGACTGTGTTACAGATATTTAATGCTACAAGGGAGTTGTCTAACACTGCGGCATATCAGTCTGTCCGCATCCTC
TCTGTCTCTCCCATTCAAGCAGAGCAGGAGCTGGAGGACCTTGTTGCGGTTGACTTGCAGTGGTCTAAGCCCACCTCAGAAAACTTAGGC
CATGGATATTTCAAGTACATGTCAGCAGTGTGCTGGCTCTTTGGACGTCACCTTTATGACACTCTGCAGTATCCCATCGGGCTGATCGCC
TCCAGCTGGGGCGGGACACCCATTGAAGCCTGGTCATCTGGACGGTCACTGAAAGCCTGTGGGGTCCCTAAACAAGGGTCCATTCCATAC
GATTCTGTAACTGGTCCCAGTAAGCACTCTGTTCTCTGGAATGCCATGATCCATCCACTGTGCAATATGACTCTGAAAGGGGTAGTATGG
TACCAGGGGGAGTCCAATATAAATTATAACACGGATCTGTACAATTGCACATTCCCTGCACTCATCGAAGACTGGCGTGAAACCTTCCAC
CGTGGTTCCCAGGGGCAGACGGAGCGTTTCTTCCCATTTGGACTTGTCCAGTTATCTTCAGATTTGTCTAAGAAGAGCTCAGACGATGGA
TTTCCCCAGATCCGTTGGCATCAAACAGCAGACTTCGGCTATGTCCCCAACCCAAAGATGCCCAATACTTTCATGGCTGTAGCTATGGAT
CTCTGTGATAGAGACTCGCCTTTTGGCAGCATCCACCCTCGAGATAAACAGACTGTGGCTTATCGGCTGCATTTGGGGGCCCGTGCTCTG
GCTTATGGTGAGAAGAATTTGACCTTTGAAGGACCACTGCCTGAGAAGATAGAACTCTTGGCTCACAAGGGGCTGCTCAATCTCACATAT
TACCAGCAAATCCAGGTGCAGAAAAAGGACAACAAGATATTTGAGATCTCCTGTTGCAGTGACCATCGATGCAAGTGGCTTCCAGCTTCT
ATGAACACCGTCTCCACCCAGTCCCTGACCCTGGCGATCGATTCTTGTCATGGCACTGTGGTTGCTCTCCGCTATGCTTGGACCACGTGG
CCTTGTGAATATAAGCAGTGTCCCCTATACCACCCCAGTAGTGCCCTGCCAGCCCCTCCCTTCATTGCTTTCATTACAGACCAGGGTCCT
GGACATCAGAGCAATGTTGCTAAATGACTGTTTCAGTATGATCAGAACTTAGATATAAGGATGGGTCCTTCAGATTTTAGCATTTAGGAG
TTTCAATAATAACCATTGCTTTTAAAGGAAATTAATAGAAAGCCTCATTGAATGGCTTTCAGCTAGCACATGGCTGTTTCTATATTCTGA
TGAGCCCAGGCTTATAGGTAACTTGAAATGCTTGCTTTTTGTTCCCTAGTTGGTCTAAGGGTCTGTATTGGACTAATTCTGAACTACAGA
CAAATTGGACCTCAATGTCATTTACTTCCCTCATATTAATGGGAGTGAAATGTCTAATACTTTTGCCCCTTTTTATCCAGAGTTGTGGGA
ATCTCAGGATTGGAAGAGATTTTAAAGGCCACATAGGCCAGCTAGTGTTCATGTGTTCTTTATAAAATTTCTCCCATCCAAGTACTAACC
AGGCCCGACCCTGCTTAGCTTCCGAGATCAGATGAGATCAGGCGCGTTCAGGGTGATATGGCCGTAGACGTCTTTACAAAATTCCTGACA
GGTGGTTACTGAATCTCTCTATGAACTTTCCATTCAAAACTTTCCAAGTTTTTCCTTATGTGGAACCGAAATCTTTCTTTCTCCCGTGAA
ACTTTACTACTATCAGATAATTGAAGACAGATCTCTTTGTATTCTCTTCAAGCCCAAACCAATTCTGTTCCTTCAATCTAAATAGTGGTA
ATATGAATGTTTAAGAAATGAAATAAGAAACATGTGCAGGCACTTTGGAAGGTGCTAAGTGACTGCCCTAAGGAATGAAAAGCAAGGGCC
AGGTGGGAGTAGCCCAGCGAAGGCACTTGGGCTGCCAGGAACAGGAGGCGTGGGAAACTCTGGCTTAGGAAAACATGAACACAGGGGCAA
CAGAGGCAAACTGTTGTTCGAGTTAAATATAAATCTCAGGCTCTTTAAAGGTAAAAGGTTTAAGGATAATCCATTTGGAAGAAGAAAAGA
GTGAGGCTGAAAGTAAAGCCACATGACAAGCATATAAAAAAAAATGCAGATGATACAAATATGAAAGAGGCCTTCAGTGTTTGTTTATTA
AGAATCTTAATGCAGTTTACTGATGGATTAAAAACAGCTAACATTGTCTGAAAATTATGTTACCTATAAGAAGTTGGAAATAAATAAAAG
CATAATCACTAGTGATGTGTATGTATTTATATCCACTTGCAAACTGTCCTTGAAGCATGTGAAAAGGAGTAAGAATACTATCTATGGGTA
GCTTTCCTCCCCTTAATGTGAAAAATGAGAACTAAAGCAAAAAGCATCACTCACTGTACATATACAATGTATTTTACGTAGTGTAAAAAA
TATGGTTTAGATAGTGAATATATTAATGAAATCATATGTAAATTTATTTTTAGTGGCTGAATAATTTAAAACATTATGTGGAATTCACTA
TGTTTCCCCCAATTTAGGAACTTTTTACTGTGTGAAAATGAAATTTATAATACTCTGTAGGGTGAATGATGGTTTTTGCTTTAGTTCTAC
CCCTCTGTAGAGTTCCAAGGGGTTCTGGTGTAGCTCCAAACAGCAGGAATAACTTTGTCAGTGCCAAGATTTTATTTAGTTAAAAAACAA
AAAATCTACACACTTTACAAGGAACGTTGGCTCCCCTGAGGACTTCCTAGCATTCAACTCGTTCAGTTAACCCCTATTGCCCATGCTTTG
ACCTCTCATGCATCTGGCCCCATAGAAACCATGAACCTTGTAACAGATTGATGCCTGAGAAAAAGTCAATCTACCCGTCCACTCCTCCAC
TCCCAATACACATACCCCCATGGGCTGTTCTAATTCGGGGGCAGCCAGAGGTAGCCAAGAACTCTAAGTCCAGATTCCTTTCACCTCCAG
GAACCTAGAGTACATAGTGTGAAAAATACGGTTCAGGCAATGATTATGTTAATGACGCCATGCACATTCATTTTTAGTGGCTGAGTAATT
TAAAACATGATGTGGGAATTCACTGCATTTCCCCAAATGTAAGAACTTTTTAGTTTTAAAATGAAATTTATAGTCACTGTAGAAAATTTG
GACACTAAAGTATAAGCAAGTAAAAATCACCCCCAAATTCATCATTCAGAGAAACACTATTTTGCTGAACCATTCACTTGACTTGAGTTA
TATAATTTTATACAGTACATATTATTTTGTAATCTGTGTTTTTGACTTACTTACTTTACCAAAATAATTTTCTTATGTAAATAATAGAAT
ATAGATTTAGAGTGTTTCAGTTTGTGGAAGCCTCATTTTATTTAACCAATTTCCTATTAATGGACATATAGATTTTTAACAATTTTCTAC
TATTAAAATAATACTGTAATGAATATCACATGCAAACATCATACCACACTCGTCCAGTTATTTCTTAGGGTTCTTAACATGGAAGAGGAT
AAATATATATTTAAAATTTAGATATCTACAGCTTAACCCTCCCAAAGGATTAAACAACTTACATTCTCACCAAGGTAGTCCTTTTTTTGC
CCTCACCCTCATTGACACTGGATGTTGTCAAATTTAAAAAAAATCCTTAACAATCTGATAGATGAAAAGATAGTTTAAGTATACTAAGGC
AGTGTTTTTCAAGGTGTTTTTGTTTTTGTTTTTGAGTTGGAGTTTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGGTCTCGGCTCA
CTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCGTGCCACCACGCCTGGC
TAATTTTTTGTATTTTTATTAGAGACCGACTTAGCCAGGATGGTCTCGATCTCCTGACCTCTTGATCCACCCGCCTCAGCCTCCCAAAGT
GCTGGGATTACAGGCGTGAGCCACCGTGCCCAGCTTTTCAAGTTTCTTAAATCCATGATCCATAGTAAAAACATTTTACACATATCTTCA
TACAAGTATATGTATATGTGGTATACGTACACACTATAGTTGTATATGCATTATAGCTGAAAAACCAGTTCAACCTTTCTACATGTGGTA
TGTTCCAAAAATTTTAAATGTCTTTCTAAAATGAGGCTCTTTTAATACGGGTATTACTCAGGCTGTAATAGTGGGAAAATATTTGTTATA
TGATAAAAGCAGCATATATCATTTCTGTGTAAATGCCAGTATGCTCAAGCCATTTATGCAGAGAAAAAAAGAAAAACACTGCATTAACAT
TTTAAGCAGTCCCCTTCCCGATTTGCTATTATACAAAGTTTGTTTCTTTTACATTGTAAAGTGTATACAACTTATAAAAAGACTATACTC
AAAATCATAAAATACCAGTTAACTTAGCTTCTCAGTTTACAGTGGCCAGTGTGGTGTGCTCTAAACACTGCTGCCTGATCCCTCCCTCTG
CTGGTCAGATTTATTACTATAAAGTACCAATCCCATTTGTGTTGTCCTCAATTGGCAATTATGAATGGCAGTGCATTAACCATTCAATTC
TCACCACTCCATCCCCATTCTTCTACTTCTGGGTCCTTTTGTCCCTCCCTTTCCAGACAGCCCTTGGTAACCTGCTGCTGGGTAACTAAG
GCATCCCACAGGTAGTGTTGAGGTGTTAGGTGATAGAGTAAACCTCTACCTTAATGCTATTAACAGGGTCCAAAAATCCAGTTGCATGGA
ACATGGAGTTATATTATTACATGGCTAATGAAAAGACAGGACTAAGTCTGTTATAGAGTATGGGACTAACCCCCAATTATATGTGAATTT

>In-frame_ENST00000371085_ENST00000263593_TCGA-BJ-A192-01A_GNAS_chr20_57486241_-_SIAE_chr11_124543777_length(amino acids)=599AA_start in transcript=1917_stop in transcript=3716
MCCAALKKIKIKIKCEQRKKKKKTTAAEKGRVQPSPEVAGGCEDCKRVESASPPPRPRPCREPTFPVLGGGQILASMVAPGLVLGLVLPL
ILWADRSAGIGFRFASYINNDMVLQKEPAGAVIWGFGTPGATVTVTLRQGQETIMKKVTSVKAHSDTWMVVLDPMKPGGPFEVMAQQTLE
KINFTLRVHDVLFGDVWLCSGQSNMQMTVLQIFNATRELSNTAAYQSVRILSVSPIQAEQELEDLVAVDLQWSKPTSENLGHGYFKYMSA
VCWLFGRHLYDTLQYPIGLIASSWGGTPIEAWSSGRSLKACGVPKQGSIPYDSVTGPSKHSVLWNAMIHPLCNMTLKGVVWYQGESNINY
NTDLYNCTFPALIEDWRETFHRGSQGQTERFFPFGLVQLSSDLSKKSSDDGFPQIRWHQTADFGYVPNPKMPNTFMAVAMDLCDRDSPFG
SIHPRDKQTVAYRLHLGARALAYGEKNLTFEGPLPEKIELLAHKGLLNLTYYQQIQVQKKDNKIFEISCCSDHRCKWLPASMNTVSTQSL

--------------------------------------------------------------
>In-frame_ENST00000354359_ENST00000263593_TCGA-BJ-A192-01A_GNAS_chr20_57486241_-_SIAE_chr11_124543777_length(transcript)=7558nt_BP=1975nt
TCGCCGCCGCCGCCTCCTCCTCCCCCCGCCTCCCCCCGCCCGCCGCGGCGCTTTTGGCTCGGGGCGGCGGCGGGGGCCCGGCCGAGGCAA
TAAGAGCGGCGGCGGCGGCAGCGGCGGCAGCAGCTCCCGCAGCTCCTGCTCTGGTCCGCCTCGGCCCGGCGGCGGCCATCAGCCCCCTCG
GCCTCGGCTCGAGGGGCGGGGAGCTGCGCGCGCCCCTCGGTCCGACCGACACCCTCCCCTTCCCGCCCGTCCGCGCGCCCCGCGGCCCGC
GGCCCGCAGTCCGCCCCGCGCGCTCCTTGCCGAGGAGCCGAGCCCGCGCCCGGCCCGCCCGCCCGGCGCTGCCCCGGCCCTCCCGGCCCG
CGTGAGGCCGCCCGCGCCCGCCGCCGCCGCAGCCCGGCCGCGCCCCGCCGCCGCCGCCGCCGCCATGGGCTGCCTCGGGAACAGTAAGAC
CGAGGACCAGCGCAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGGC
CACGCACCGCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAA
TGGAGAGGGCGGCGAAGAGGACCCGCAGGCTGCAAGGAGCAACAGCGATGGCAGTGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAA
CCTGAAAGAGGCGATTGAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGT
GGACTACATCCTGAGTGTGATGAACGTGCCTGACTTTGACTTCCCTCCCGAATTCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGG
AGTGCGTGCCTGCTACGAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGTACTTCCTGGACAAGATCGACGTGATCAAGCAGGC
TGACTATGTGCCGAGCGATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAA
CTTCCACATGTTTGACGTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGTGCTTCAACGATGTGACTGCCATCATCTTCGTGGT
GGCCAGCAGCAGCTACAACATGGTCATCCGGGAGGACAACCAGACCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAA
CAACAGATGGCTGCGCACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGAT
TGAGGACTACTTTCCAGAATTTGCTCGCTACACTACTCCTGAGGATGCTACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAA
GTACTTCATTCGAGATGAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTCACTACTGCTACCCTCATTTCACCTGCGCTGTGGA
CACTGAGAACATCCGCCGTGTGTTCAACGACTGCCGTGACATCATTCAGCGCATGCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAA
CCCCCAAATTTAATTAAAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAATTGTACAAGCAGTTAATCACCCACCATAGGGCATGATT
AACAAAGCAACCTTTCCCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCTTCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTA
AGGCGGCCTACAGAAAAAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAGTAAAAATAAATAAAACAGCAGCAGCAAACAAATAAA
ATGAAATAAAAGAAACAAATGAAATAAATATTGTGTTGTGCAGCATTAAAAAAAATCAAAATAAAAATTAAATGTGAGCAAAGAAAAAAA
AAAAAAAAAACTACGGCGGCCGAGAAGGGGCGAGTACAGCCCAGTCCTGAGGTCGCGGGAGGCTGCGAGGACTGCAAAAGGGTGGAGTCG
GCCTCGCCCCCGCCCAGGCCCCGCCCCTGCCGGGAACCCACTTTCCCAGTCCTAGGCGGCGGTCAGATCCTTGCAAGCATGGTCGCGCCG
GGGCTTGTACTCGGGCTGGTGCTGCCATTAATCCTGTGGGCCGACAGAAGTGCAGGTATTGGTTTTCGCTTTGCTTCATACATCAATAAT
GATATGGTGCTGCAGAAGGAGCCTGCTGGGGCAGTGATATGGGGCTTCGGTACACCTGGAGCCACAGTGACCGTGACCCTGCGCCAAGGT
CAGGAAACCATCATGAAGAAAGTGACCAGTGTGAAAGCTCACTCTGATACGTGGATGGTGGTACTGGATCCTATGAAGCCTGGAGGACCT
TTCGAAGTGATGGCACAACAGACTTTGGAGAAAATAAACTTCACCCTGAGAGTTCATGACGTCCTGTTTGGAGATGTCTGGCTCTGTAGT
GGGCAGAGTAACATGCAGATGACTGTGTTACAGATATTTAATGCTACAAGGGAGTTGTCTAACACTGCGGCATATCAGTCTGTCCGCATC
CTCTCTGTCTCTCCCATTCAAGCAGAGCAGGAGCTGGAGGACCTTGTTGCGGTTGACTTGCAGTGGTCTAAGCCCACCTCAGAAAACTTA
GGCCATGGATATTTCAAGTACATGTCAGCAGTGTGCTGGCTCTTTGGACGTCACCTTTATGACACTCTGCAGTATCCCATCGGGCTGATC
GCCTCCAGCTGGGGCGGGACACCCATTGAAGCCTGGTCATCTGGACGGTCACTGAAAGCCTGTGGGGTCCCTAAACAAGGGTCCATTCCA
TACGATTCTGTAACTGGTCCCAGTAAGCACTCTGTTCTCTGGAATGCCATGATCCATCCACTGTGCAATATGACTCTGAAAGGGGTAGTA
TGGTACCAGGGGGAGTCCAATATAAATTATAACACGGATCTGTACAATTGCACATTCCCTGCACTCATCGAAGACTGGCGTGAAACCTTC
CACCGTGGTTCCCAGGGGCAGACGGAGCGTTTCTTCCCATTTGGACTTGTCCAGTTATCTTCAGATTTGTCTAAGAAGAGCTCAGACGAT
GGATTTCCCCAGATCCGTTGGCATCAAACAGCAGACTTCGGCTATGTCCCCAACCCAAAGATGCCCAATACTTTCATGGCTGTAGCTATG
GATCTCTGTGATAGAGACTCGCCTTTTGGCAGCATCCACCCTCGAGATAAACAGACTGTGGCTTATCGGCTGCATTTGGGGGCCCGTGCT
CTGGCTTATGGTGAGAAGAATTTGACCTTTGAAGGACCACTGCCTGAGAAGATAGAACTCTTGGCTCACAAGGGGCTGCTCAATCTCACA
TATTACCAGCAAATCCAGGTGCAGAAAAAGGACAACAAGATATTTGAGATCTCCTGTTGCAGTGACCATCGATGCAAGTGGCTTCCAGCT
TCTATGAACACCGTCTCCACCCAGTCCCTGACCCTGGCGATCGATTCTTGTCATGGCACTGTGGTTGCTCTCCGCTATGCTTGGACCACG
TGGCCTTGTGAATATAAGCAGTGTCCCCTATACCACCCCAGTAGTGCCCTGCCAGCCCCTCCCTTCATTGCTTTCATTACAGACCAGGGT
CCTGGACATCAGAGCAATGTTGCTAAATGACTGTTTCAGTATGATCAGAACTTAGATATAAGGATGGGTCCTTCAGATTTTAGCATTTAG
GAGTTTCAATAATAACCATTGCTTTTAAAGGAAATTAATAGAAAGCCTCATTGAATGGCTTTCAGCTAGCACATGGCTGTTTCTATATTC
TGATGAGCCCAGGCTTATAGGTAACTTGAAATGCTTGCTTTTTGTTCCCTAGTTGGTCTAAGGGTCTGTATTGGACTAATTCTGAACTAC
AGACAAATTGGACCTCAATGTCATTTACTTCCCTCATATTAATGGGAGTGAAATGTCTAATACTTTTGCCCCTTTTTATCCAGAGTTGTG
GGAATCTCAGGATTGGAAGAGATTTTAAAGGCCACATAGGCCAGCTAGTGTTCATGTGTTCTTTATAAAATTTCTCCCATCCAAGTACTA
ACCAGGCCCGACCCTGCTTAGCTTCCGAGATCAGATGAGATCAGGCGCGTTCAGGGTGATATGGCCGTAGACGTCTTTACAAAATTCCTG
ACAGGTGGTTACTGAATCTCTCTATGAACTTTCCATTCAAAACTTTCCAAGTTTTTCCTTATGTGGAACCGAAATCTTTCTTTCTCCCGT
GAAACTTTACTACTATCAGATAATTGAAGACAGATCTCTTTGTATTCTCTTCAAGCCCAAACCAATTCTGTTCCTTCAATCTAAATAGTG
GTAATATGAATGTTTAAGAAATGAAATAAGAAACATGTGCAGGCACTTTGGAAGGTGCTAAGTGACTGCCCTAAGGAATGAAAAGCAAGG
GCCAGGTGGGAGTAGCCCAGCGAAGGCACTTGGGCTGCCAGGAACAGGAGGCGTGGGAAACTCTGGCTTAGGAAAACATGAACACAGGGG
CAACAGAGGCAAACTGTTGTTCGAGTTAAATATAAATCTCAGGCTCTTTAAAGGTAAAAGGTTTAAGGATAATCCATTTGGAAGAAGAAA
AGAGTGAGGCTGAAAGTAAAGCCACATGACAAGCATATAAAAAAAAATGCAGATGATACAAATATGAAAGAGGCCTTCAGTGTTTGTTTA
TTAAGAATCTTAATGCAGTTTACTGATGGATTAAAAACAGCTAACATTGTCTGAAAATTATGTTACCTATAAGAAGTTGGAAATAAATAA
AAGCATAATCACTAGTGATGTGTATGTATTTATATCCACTTGCAAACTGTCCTTGAAGCATGTGAAAAGGAGTAAGAATACTATCTATGG
GTAGCTTTCCTCCCCTTAATGTGAAAAATGAGAACTAAAGCAAAAAGCATCACTCACTGTACATATACAATGTATTTTACGTAGTGTAAA
AAATATGGTTTAGATAGTGAATATATTAATGAAATCATATGTAAATTTATTTTTAGTGGCTGAATAATTTAAAACATTATGTGGAATTCA
CTATGTTTCCCCCAATTTAGGAACTTTTTACTGTGTGAAAATGAAATTTATAATACTCTGTAGGGTGAATGATGGTTTTTGCTTTAGTTC
TACCCCTCTGTAGAGTTCCAAGGGGTTCTGGTGTAGCTCCAAACAGCAGGAATAACTTTGTCAGTGCCAAGATTTTATTTAGTTAAAAAA
CAAAAAATCTACACACTTTACAAGGAACGTTGGCTCCCCTGAGGACTTCCTAGCATTCAACTCGTTCAGTTAACCCCTATTGCCCATGCT
TTGACCTCTCATGCATCTGGCCCCATAGAAACCATGAACCTTGTAACAGATTGATGCCTGAGAAAAAGTCAATCTACCCGTCCACTCCTC
CACTCCCAATACACATACCCCCATGGGCTGTTCTAATTCGGGGGCAGCCAGAGGTAGCCAAGAACTCTAAGTCCAGATTCCTTTCACCTC
CAGGAACCTAGAGTACATAGTGTGAAAAATACGGTTCAGGCAATGATTATGTTAATGACGCCATGCACATTCATTTTTAGTGGCTGAGTA
ATTTAAAACATGATGTGGGAATTCACTGCATTTCCCCAAATGTAAGAACTTTTTAGTTTTAAAATGAAATTTATAGTCACTGTAGAAAAT
TTGGACACTAAAGTATAAGCAAGTAAAAATCACCCCCAAATTCATCATTCAGAGAAACACTATTTTGCTGAACCATTCACTTGACTTGAG
TTATATAATTTTATACAGTACATATTATTTTGTAATCTGTGTTTTTGACTTACTTACTTTACCAAAATAATTTTCTTATGTAAATAATAG
AATATAGATTTAGAGTGTTTCAGTTTGTGGAAGCCTCATTTTATTTAACCAATTTCCTATTAATGGACATATAGATTTTTAACAATTTTC
TACTATTAAAATAATACTGTAATGAATATCACATGCAAACATCATACCACACTCGTCCAGTTATTTCTTAGGGTTCTTAACATGGAAGAG
GATAAATATATATTTAAAATTTAGATATCTACAGCTTAACCCTCCCAAAGGATTAAACAACTTACATTCTCACCAAGGTAGTCCTTTTTT
TGCCCTCACCCTCATTGACACTGGATGTTGTCAAATTTAAAAAAAATCCTTAACAATCTGATAGATGAAAAGATAGTTTAAGTATACTAA
GGCAGTGTTTTTCAAGGTGTTTTTGTTTTTGTTTTTGAGTTGGAGTTTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGGTCTCGGC
TCACTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCGTGCCACCACGCCT
GGCTAATTTTTTGTATTTTTATTAGAGACCGACTTAGCCAGGATGGTCTCGATCTCCTGACCTCTTGATCCACCCGCCTCAGCCTCCCAA
AGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCAGCTTTTCAAGTTTCTTAAATCCATGATCCATAGTAAAAACATTTTACACATATCT
TCATACAAGTATATGTATATGTGGTATACGTACACACTATAGTTGTATATGCATTATAGCTGAAAAACCAGTTCAACCTTTCTACATGTG
GTATGTTCCAAAAATTTTAAATGTCTTTCTAAAATGAGGCTCTTTTAATACGGGTATTACTCAGGCTGTAATAGTGGGAAAATATTTGTT
ATATGATAAAAGCAGCATATATCATTTCTGTGTAAATGCCAGTATGCTCAAGCCATTTATGCAGAGAAAAAAAGAAAAACACTGCATTAA
CATTTTAAGCAGTCCCCTTCCCGATTTGCTATTATACAAAGTTTGTTTCTTTTACATTGTAAAGTGTATACAACTTATAAAAAGACTATA
CTCAAAATCATAAAATACCAGTTAACTTAGCTTCTCAGTTTACAGTGGCCAGTGTGGTGTGCTCTAAACACTGCTGCCTGATCCCTCCCT
CTGCTGGTCAGATTTATTACTATAAAGTACCAATCCCATTTGTGTTGTCCTCAATTGGCAATTATGAATGGCAGTGCATTAACCATTCAA
TTCTCACCACTCCATCCCCATTCTTCTACTTCTGGGTCCTTTTGTCCCTCCCTTTCCAGACAGCCCTTGGTAACCTGCTGCTGGGTAACT
AAGGCATCCCACAGGTAGTGTTGAGGTGTTAGGTGATAGAGTAAACCTCTACCTTAATGCTATTAACAGGGTCCAAAAATCCAGTTGCAT
GGAACATGGAGTTATATTATTACATGGCTAATGAAAAGACAGGACTAAGTCTGTTATAGAGTATGGGACTAACCCCCAATTATATGTGAA

>In-frame_ENST00000354359_ENST00000263593_TCGA-BJ-A192-01A_GNAS_chr20_57486241_-_SIAE_chr11_124543777_length(amino acids)=599AA_start in transcript=1920_stop in transcript=3719
MCCAALKKIKIKIKCEQRKKKKKTTAAEKGRVQPSPEVAGGCEDCKRVESASPPPRPRPCREPTFPVLGGGQILASMVAPGLVLGLVLPL
ILWADRSAGIGFRFASYINNDMVLQKEPAGAVIWGFGTPGATVTVTLRQGQETIMKKVTSVKAHSDTWMVVLDPMKPGGPFEVMAQQTLE
KINFTLRVHDVLFGDVWLCSGQSNMQMTVLQIFNATRELSNTAAYQSVRILSVSPIQAEQELEDLVAVDLQWSKPTSENLGHGYFKYMSA
VCWLFGRHLYDTLQYPIGLIASSWGGTPIEAWSSGRSLKACGVPKQGSIPYDSVTGPSKHSVLWNAMIHPLCNMTLKGVVWYQGESNINY
NTDLYNCTFPALIEDWRETFHRGSQGQTERFFPFGLVQLSSDLSKKSSDDGFPQIRWHQTADFGYVPNPKMPNTFMAVAMDLCDRDSPFG
SIHPRDKQTVAYRLHLGARALAYGEKNLTFEGPLPEKIELLAHKGLLNLTYYQQIQVQKKDNKIFEISCCSDHRCKWLPASMNTVSTQSL

--------------------------------------------------------------
>In-frame_ENST00000265620_ENST00000263593_TCGA-BJ-A192-01A_GNAS_chr20_57486241_-_SIAE_chr11_124543777_length(transcript)=7449nt_BP=1866nt
GGGCGGCGGCGGGGGCCCGGCCGAGGCAATAAGAGCGGCGGCGGCGGCAGCGGCGGCAGCAGCTCCCGCAGCTCCTGCTCTGGTCCGCCT
CGGCCCGGCGGCGGCCATCAGCCCCCTCGGCCTCGGCTCGAGGGGCGGGGAGCTGCGCGCGCCCCTCGGTCCGACCGACACCCTCCCCTT
CCCGCCCGTCCGCGCGCCCCGCGGCCCGCGGCCCGCAGTCCGCCCCGCGCGCTCCTTGCCGAGGAGCCGAGCCCGCGCCCGGCCCGCCCG
CCCGGCGCTGCCCCGGCCCTCCCGGCCCGCGTGAGGCCGCCCGCGCCCGCCGCCGCCGCAGCCCGGCCGCGCCCCGCCGCCGCCGCCGCC
GCCATGGGCTGCCTCGGGAACAGTAAGACCGAGGACCAGCGCAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCGAGAAGCAG
CTGCAGAAGGACAAGCAGGTCTACCGGGCCACGCACCGCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAG
ATGAGGATCCTGCATGTTAATGGGTTTAATGGAGATGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGGCGATTGAA
ACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCGTGGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGTGTG
ATGAACGTGCCTGACTTTGACTTCCCTCCCGAATTCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCTGCTACGAA
CGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGTACTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGACTATGTGCCGAGCGAT
CAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGTTTGACGTG
GGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGTGCTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTACAAC
ATGGTCATCCGGGAGGACAACCAGACCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGCTGCGCACC
ATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGCTCGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGAGGACTACTTTCCAGAA
TTTGCTCGCTACACTACTCCTGAGGATGCTACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTCGAGATGAG
TTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTCACTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGCCGT
GTGTTCAACGACTGCCGTGACATCATTCAGCGCATGCACCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTTAATTAAAG
CCTTAAGCACAATTAATTAAAAGTGAAACGTAATTGTACAAGCAGTTAATCACCCACCATAGGGCATGATTAACAAAGCAACCTTTCCCT
TCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCTTCAGCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTACAGAAAAAG
GAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAGTAAAAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAAGAAACAAA
TGAAATAAATATTGTGTTGTGCAGCATTAAAAAAAATCAAAATAAAAATTAAATGTGAGCAAAGAAAAAAAAAAAAAAAAACTACGGCGG
CCGAGAAGGGGCGAGTACAGCCCAGTCCTGAGGTCGCGGGAGGCTGCGAGGACTGCAAAAGGGTGGAGTCGGCCTCGCCCCCGCCCAGGC
CCCGCCCCTGCCGGGAACCCACTTTCCCAGTCCTAGGCGGCGGTCAGATCCTTGCAAGCATGGTCGCGCCGGGGCTTGTACTCGGGCTGG
TGCTGCCATTAATCCTGTGGGCCGACAGAAGTGCAGGTATTGGTTTTCGCTTTGCTTCATACATCAATAATGATATGGTGCTGCAGAAGG
AGCCTGCTGGGGCAGTGATATGGGGCTTCGGTACACCTGGAGCCACAGTGACCGTGACCCTGCGCCAAGGTCAGGAAACCATCATGAAGA
AAGTGACCAGTGTGAAAGCTCACTCTGATACGTGGATGGTGGTACTGGATCCTATGAAGCCTGGAGGACCTTTCGAAGTGATGGCACAAC
AGACTTTGGAGAAAATAAACTTCACCCTGAGAGTTCATGACGTCCTGTTTGGAGATGTCTGGCTCTGTAGTGGGCAGAGTAACATGCAGA
TGACTGTGTTACAGATATTTAATGCTACAAGGGAGTTGTCTAACACTGCGGCATATCAGTCTGTCCGCATCCTCTCTGTCTCTCCCATTC
AAGCAGAGCAGGAGCTGGAGGACCTTGTTGCGGTTGACTTGCAGTGGTCTAAGCCCACCTCAGAAAACTTAGGCCATGGATATTTCAAGT
ACATGTCAGCAGTGTGCTGGCTCTTTGGACGTCACCTTTATGACACTCTGCAGTATCCCATCGGGCTGATCGCCTCCAGCTGGGGCGGGA
CACCCATTGAAGCCTGGTCATCTGGACGGTCACTGAAAGCCTGTGGGGTCCCTAAACAAGGGTCCATTCCATACGATTCTGTAACTGGTC
CCAGTAAGCACTCTGTTCTCTGGAATGCCATGATCCATCCACTGTGCAATATGACTCTGAAAGGGGTAGTATGGTACCAGGGGGAGTCCA
ATATAAATTATAACACGGATCTGTACAATTGCACATTCCCTGCACTCATCGAAGACTGGCGTGAAACCTTCCACCGTGGTTCCCAGGGGC
AGACGGAGCGTTTCTTCCCATTTGGACTTGTCCAGTTATCTTCAGATTTGTCTAAGAAGAGCTCAGACGATGGATTTCCCCAGATCCGTT
GGCATCAAACAGCAGACTTCGGCTATGTCCCCAACCCAAAGATGCCCAATACTTTCATGGCTGTAGCTATGGATCTCTGTGATAGAGACT
CGCCTTTTGGCAGCATCCACCCTCGAGATAAACAGACTGTGGCTTATCGGCTGCATTTGGGGGCCCGTGCTCTGGCTTATGGTGAGAAGA
ATTTGACCTTTGAAGGACCACTGCCTGAGAAGATAGAACTCTTGGCTCACAAGGGGCTGCTCAATCTCACATATTACCAGCAAATCCAGG
TGCAGAAAAAGGACAACAAGATATTTGAGATCTCCTGTTGCAGTGACCATCGATGCAAGTGGCTTCCAGCTTCTATGAACACCGTCTCCA
CCCAGTCCCTGACCCTGGCGATCGATTCTTGTCATGGCACTGTGGTTGCTCTCCGCTATGCTTGGACCACGTGGCCTTGTGAATATAAGC
AGTGTCCCCTATACCACCCCAGTAGTGCCCTGCCAGCCCCTCCCTTCATTGCTTTCATTACAGACCAGGGTCCTGGACATCAGAGCAATG
TTGCTAAATGACTGTTTCAGTATGATCAGAACTTAGATATAAGGATGGGTCCTTCAGATTTTAGCATTTAGGAGTTTCAATAATAACCAT
TGCTTTTAAAGGAAATTAATAGAAAGCCTCATTGAATGGCTTTCAGCTAGCACATGGCTGTTTCTATATTCTGATGAGCCCAGGCTTATA
GGTAACTTGAAATGCTTGCTTTTTGTTCCCTAGTTGGTCTAAGGGTCTGTATTGGACTAATTCTGAACTACAGACAAATTGGACCTCAAT
GTCATTTACTTCCCTCATATTAATGGGAGTGAAATGTCTAATACTTTTGCCCCTTTTTATCCAGAGTTGTGGGAATCTCAGGATTGGAAG
AGATTTTAAAGGCCACATAGGCCAGCTAGTGTTCATGTGTTCTTTATAAAATTTCTCCCATCCAAGTACTAACCAGGCCCGACCCTGCTT
AGCTTCCGAGATCAGATGAGATCAGGCGCGTTCAGGGTGATATGGCCGTAGACGTCTTTACAAAATTCCTGACAGGTGGTTACTGAATCT
CTCTATGAACTTTCCATTCAAAACTTTCCAAGTTTTTCCTTATGTGGAACCGAAATCTTTCTTTCTCCCGTGAAACTTTACTACTATCAG
ATAATTGAAGACAGATCTCTTTGTATTCTCTTCAAGCCCAAACCAATTCTGTTCCTTCAATCTAAATAGTGGTAATATGAATGTTTAAGA
AATGAAATAAGAAACATGTGCAGGCACTTTGGAAGGTGCTAAGTGACTGCCCTAAGGAATGAAAAGCAAGGGCCAGGTGGGAGTAGCCCA
GCGAAGGCACTTGGGCTGCCAGGAACAGGAGGCGTGGGAAACTCTGGCTTAGGAAAACATGAACACAGGGGCAACAGAGGCAAACTGTTG
TTCGAGTTAAATATAAATCTCAGGCTCTTTAAAGGTAAAAGGTTTAAGGATAATCCATTTGGAAGAAGAAAAGAGTGAGGCTGAAAGTAA
AGCCACATGACAAGCATATAAAAAAAAATGCAGATGATACAAATATGAAAGAGGCCTTCAGTGTTTGTTTATTAAGAATCTTAATGCAGT
TTACTGATGGATTAAAAACAGCTAACATTGTCTGAAAATTATGTTACCTATAAGAAGTTGGAAATAAATAAAAGCATAATCACTAGTGAT
GTGTATGTATTTATATCCACTTGCAAACTGTCCTTGAAGCATGTGAAAAGGAGTAAGAATACTATCTATGGGTAGCTTTCCTCCCCTTAA
TGTGAAAAATGAGAACTAAAGCAAAAAGCATCACTCACTGTACATATACAATGTATTTTACGTAGTGTAAAAAATATGGTTTAGATAGTG
AATATATTAATGAAATCATATGTAAATTTATTTTTAGTGGCTGAATAATTTAAAACATTATGTGGAATTCACTATGTTTCCCCCAATTTA
GGAACTTTTTACTGTGTGAAAATGAAATTTATAATACTCTGTAGGGTGAATGATGGTTTTTGCTTTAGTTCTACCCCTCTGTAGAGTTCC
AAGGGGTTCTGGTGTAGCTCCAAACAGCAGGAATAACTTTGTCAGTGCCAAGATTTTATTTAGTTAAAAAACAAAAAATCTACACACTTT
ACAAGGAACGTTGGCTCCCCTGAGGACTTCCTAGCATTCAACTCGTTCAGTTAACCCCTATTGCCCATGCTTTGACCTCTCATGCATCTG
GCCCCATAGAAACCATGAACCTTGTAACAGATTGATGCCTGAGAAAAAGTCAATCTACCCGTCCACTCCTCCACTCCCAATACACATACC
CCCATGGGCTGTTCTAATTCGGGGGCAGCCAGAGGTAGCCAAGAACTCTAAGTCCAGATTCCTTTCACCTCCAGGAACCTAGAGTACATA
GTGTGAAAAATACGGTTCAGGCAATGATTATGTTAATGACGCCATGCACATTCATTTTTAGTGGCTGAGTAATTTAAAACATGATGTGGG
AATTCACTGCATTTCCCCAAATGTAAGAACTTTTTAGTTTTAAAATGAAATTTATAGTCACTGTAGAAAATTTGGACACTAAAGTATAAG
CAAGTAAAAATCACCCCCAAATTCATCATTCAGAGAAACACTATTTTGCTGAACCATTCACTTGACTTGAGTTATATAATTTTATACAGT
ACATATTATTTTGTAATCTGTGTTTTTGACTTACTTACTTTACCAAAATAATTTTCTTATGTAAATAATAGAATATAGATTTAGAGTGTT
TCAGTTTGTGGAAGCCTCATTTTATTTAACCAATTTCCTATTAATGGACATATAGATTTTTAACAATTTTCTACTATTAAAATAATACTG
TAATGAATATCACATGCAAACATCATACCACACTCGTCCAGTTATTTCTTAGGGTTCTTAACATGGAAGAGGATAAATATATATTTAAAA
TTTAGATATCTACAGCTTAACCCTCCCAAAGGATTAAACAACTTACATTCTCACCAAGGTAGTCCTTTTTTTGCCCTCACCCTCATTGAC
ACTGGATGTTGTCAAATTTAAAAAAAATCCTTAACAATCTGATAGATGAAAAGATAGTTTAAGTATACTAAGGCAGTGTTTTTCAAGGTG
TTTTTGTTTTTGTTTTTGAGTTGGAGTTTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGGTCTCGGCTCACTGCAACCTCTGCCTC
CCGGGTTCAAGCGATTCTTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCGTGCCACCACGCCTGGCTAATTTTTTGTATTTT
TATTAGAGACCGACTTAGCCAGGATGGTCTCGATCTCCTGACCTCTTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCG
TGAGCCACCGTGCCCAGCTTTTCAAGTTTCTTAAATCCATGATCCATAGTAAAAACATTTTACACATATCTTCATACAAGTATATGTATA
TGTGGTATACGTACACACTATAGTTGTATATGCATTATAGCTGAAAAACCAGTTCAACCTTTCTACATGTGGTATGTTCCAAAAATTTTA
AATGTCTTTCTAAAATGAGGCTCTTTTAATACGGGTATTACTCAGGCTGTAATAGTGGGAAAATATTTGTTATATGATAAAAGCAGCATA
TATCATTTCTGTGTAAATGCCAGTATGCTCAAGCCATTTATGCAGAGAAAAAAAGAAAAACACTGCATTAACATTTTAAGCAGTCCCCTT
CCCGATTTGCTATTATACAAAGTTTGTTTCTTTTACATTGTAAAGTGTATACAACTTATAAAAAGACTATACTCAAAATCATAAAATACC
AGTTAACTTAGCTTCTCAGTTTACAGTGGCCAGTGTGGTGTGCTCTAAACACTGCTGCCTGATCCCTCCCTCTGCTGGTCAGATTTATTA
CTATAAAGTACCAATCCCATTTGTGTTGTCCTCAATTGGCAATTATGAATGGCAGTGCATTAACCATTCAATTCTCACCACTCCATCCCC
ATTCTTCTACTTCTGGGTCCTTTTGTCCCTCCCTTTCCAGACAGCCCTTGGTAACCTGCTGCTGGGTAACTAAGGCATCCCACAGGTAGT
GTTGAGGTGTTAGGTGATAGAGTAAACCTCTACCTTAATGCTATTAACAGGGTCCAAAAATCCAGTTGCATGGAACATGGAGTTATATTA
TTACATGGCTAATGAAAAGACAGGACTAAGTCTGTTATAGAGTATGGGACTAACCCCCAATTATATGTGAATTTGTGTTATCATATGGTT

>In-frame_ENST00000265620_ENST00000263593_TCGA-BJ-A192-01A_GNAS_chr20_57486241_-_SIAE_chr11_124543777_length(amino acids)=599AA_start in transcript=1811_stop in transcript=3610
MCCAALKKIKIKIKCEQRKKKKKTTAAEKGRVQPSPEVAGGCEDCKRVESASPPPRPRPCREPTFPVLGGGQILASMVAPGLVLGLVLPL
ILWADRSAGIGFRFASYINNDMVLQKEPAGAVIWGFGTPGATVTVTLRQGQETIMKKVTSVKAHSDTWMVVLDPMKPGGPFEVMAQQTLE
KINFTLRVHDVLFGDVWLCSGQSNMQMTVLQIFNATRELSNTAAYQSVRILSVSPIQAEQELEDLVAVDLQWSKPTSENLGHGYFKYMSA
VCWLFGRHLYDTLQYPIGLIASSWGGTPIEAWSSGRSLKACGVPKQGSIPYDSVTGPSKHSVLWNAMIHPLCNMTLKGVVWYQGESNINY
NTDLYNCTFPALIEDWRETFHRGSQGQTERFFPFGLVQLSSDLSKKSSDDGFPQIRWHQTADFGYVPNPKMPNTFMAVAMDLCDRDSPFG
SIHPRDKQTVAYRLHLGARALAYGEKNLTFEGPLPEKIELLAHKGLLNLTYYQQIQVQKKDNKIFEISCCSDHRCKWLPASMNTVSTQSL

--------------------------------------------------------------
>In-frame_ENST00000306090_ENST00000263593_TCGA-BJ-A192-01A_GNAS_chr20_57486241_-_SIAE_chr11_124543777_length(transcript)=7225nt_BP=1642nt
CAGCGGCGGCAGCAGCTCCCGCAGCTCCTGCTCTGGTCCGCCTCGGCCCGGCGGCGGCCATCAGCCCCCTCGGCCTCGGCTCGAGGGGCG
GGGAGCTGCGCGCGCCCCTCGGTCCGACCGACACCCTCCCCTTCCCGCCCCCATGGGCTGCCTCGGGAACAGTAAGACCGAGGACCAGCG
CAACGAGGAGAAGGCGCAGCGTGAGGCCAACAAAAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGGCCACGCACCGCCT
GCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATGAGGATCCTGCATGTTAATGGGTTTAATGGAGACAGTGA
GAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAAGAGGCGATTGAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCGT
GGAGCTGGCCAACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGTGTGATGAACGTGCCTGACTTTGACTTCCCTCCCGAATTCTA
TGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGTGCCTGCTACGAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGTA
CTTCCTGGACAAGATCGACGTGATCAAGCAGGCTGACTATGTGCCGAGCGATCAGGACCTGCTTCGCTGCCGTGTCCTGACTTCTGGAAT
CTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCACATGTTTGACGTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGTG
CTTCAACGATGTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTACAACATGGTCATCCGGGAGGACAACCAGACCAACCGCCTGCA
GGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGATGGCTGCGCACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGCT
CGCTGAGAAAGTCCTTGCTGGGAAATCGAAGATTGAGGACTACTTTCCAGAATTTGCTCGCTACACTACTCCTGAGGATGCTACTCCCGA
GCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTCATTCGAGATGAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTCA
CTACTGCTACCCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGCCGTGTGTTCAACGACTGCCGTGACATCATTCAGCGCATGCA
CCTTCGTCAGTACGAGCTGCTCTAAGAAGGGAACCCCCAAATTTAATTAAAGCCTTAAGCACAATTAATTAAAAGTGAAACGTAATTGTA
CAAGCAGTTAATCACCCACCATAGGGCATGATTAACAAAGCAACCTTTCCCTTCCCCCGAGTGATTTTGCGAAACCCCCTTTTCCCTTCA
GCTTGCTTAGATGTTCCAAATTTAGAAAGCTTAAGGCGGCCTACAGAAAAAGGAAAAAAGGCCACAAAAGTTCCCTCTCACTTTCAGTAA
AAATAAATAAAACAGCAGCAGCAAACAAATAAAATGAAATAAAAGAAACAAATGAAATAAATATTGTGTTGTGCAGCATTAAAAAAAATC
AAAATAAAAATTAAATGTGAGCAAAAAAAAAAAAAAACTACGGCGGCCGAGAAGGGGCGAGTACAGCCCAGTCCTGAGGTCGCGGGAGGC
TGCGAGGACTGCAAAAGGGTGGAGTCGGCCTCGCCCCCGCCCAGGCCCCGCCCCTGCCGGGAACCCACTTTCCCAGTCCTAGGCGGCGGT
CAGATCCTTGCAAGCATGGTCGCGCCGGGGCTTGTACTCGGGCTGGTGCTGCCATTAATCCTGTGGGCCGACAGAAGTGCAGGTATTGGT
TTTCGCTTTGCTTCATACATCAATAATGATATGGTGCTGCAGAAGGAGCCTGCTGGGGCAGTGATATGGGGCTTCGGTACACCTGGAGCC
ACAGTGACCGTGACCCTGCGCCAAGGTCAGGAAACCATCATGAAGAAAGTGACCAGTGTGAAAGCTCACTCTGATACGTGGATGGTGGTA
CTGGATCCTATGAAGCCTGGAGGACCTTTCGAAGTGATGGCACAACAGACTTTGGAGAAAATAAACTTCACCCTGAGAGTTCATGACGTC
CTGTTTGGAGATGTCTGGCTCTGTAGTGGGCAGAGTAACATGCAGATGACTGTGTTACAGATATTTAATGCTACAAGGGAGTTGTCTAAC
ACTGCGGCATATCAGTCTGTCCGCATCCTCTCTGTCTCTCCCATTCAAGCAGAGCAGGAGCTGGAGGACCTTGTTGCGGTTGACTTGCAG
TGGTCTAAGCCCACCTCAGAAAACTTAGGCCATGGATATTTCAAGTACATGTCAGCAGTGTGCTGGCTCTTTGGACGTCACCTTTATGAC
ACTCTGCAGTATCCCATCGGGCTGATCGCCTCCAGCTGGGGCGGGACACCCATTGAAGCCTGGTCATCTGGACGGTCACTGAAAGCCTGT
GGGGTCCCTAAACAAGGGTCCATTCCATACGATTCTGTAACTGGTCCCAGTAAGCACTCTGTTCTCTGGAATGCCATGATCCATCCACTG
TGCAATATGACTCTGAAAGGGGTAGTATGGTACCAGGGGGAGTCCAATATAAATTATAACACGGATCTGTACAATTGCACATTCCCTGCA
CTCATCGAAGACTGGCGTGAAACCTTCCACCGTGGTTCCCAGGGGCAGACGGAGCGTTTCTTCCCATTTGGACTTGTCCAGTTATCTTCA
GATTTGTCTAAGAAGAGCTCAGACGATGGATTTCCCCAGATCCGTTGGCATCAAACAGCAGACTTCGGCTATGTCCCCAACCCAAAGATG
CCCAATACTTTCATGGCTGTAGCTATGGATCTCTGTGATAGAGACTCGCCTTTTGGCAGCATCCACCCTCGAGATAAACAGACTGTGGCT
TATCGGCTGCATTTGGGGGCCCGTGCTCTGGCTTATGGTGAGAAGAATTTGACCTTTGAAGGACCACTGCCTGAGAAGATAGAACTCTTG
GCTCACAAGGGGCTGCTCAATCTCACATATTACCAGCAAATCCAGGTGCAGAAAAAGGACAACAAGATATTTGAGATCTCCTGTTGCAGT
GACCATCGATGCAAGTGGCTTCCAGCTTCTATGAACACCGTCTCCACCCAGTCCCTGACCCTGGCGATCGATTCTTGTCATGGCACTGTG
GTTGCTCTCCGCTATGCTTGGACCACGTGGCCTTGTGAATATAAGCAGTGTCCCCTATACCACCCCAGTAGTGCCCTGCCAGCCCCTCCC
TTCATTGCTTTCATTACAGACCAGGGTCCTGGACATCAGAGCAATGTTGCTAAATGACTGTTTCAGTATGATCAGAACTTAGATATAAGG
ATGGGTCCTTCAGATTTTAGCATTTAGGAGTTTCAATAATAACCATTGCTTTTAAAGGAAATTAATAGAAAGCCTCATTGAATGGCTTTC
AGCTAGCACATGGCTGTTTCTATATTCTGATGAGCCCAGGCTTATAGGTAACTTGAAATGCTTGCTTTTTGTTCCCTAGTTGGTCTAAGG
GTCTGTATTGGACTAATTCTGAACTACAGACAAATTGGACCTCAATGTCATTTACTTCCCTCATATTAATGGGAGTGAAATGTCTAATAC
TTTTGCCCCTTTTTATCCAGAGTTGTGGGAATCTCAGGATTGGAAGAGATTTTAAAGGCCACATAGGCCAGCTAGTGTTCATGTGTTCTT
TATAAAATTTCTCCCATCCAAGTACTAACCAGGCCCGACCCTGCTTAGCTTCCGAGATCAGATGAGATCAGGCGCGTTCAGGGTGATATG
GCCGTAGACGTCTTTACAAAATTCCTGACAGGTGGTTACTGAATCTCTCTATGAACTTTCCATTCAAAACTTTCCAAGTTTTTCCTTATG
TGGAACCGAAATCTTTCTTTCTCCCGTGAAACTTTACTACTATCAGATAATTGAAGACAGATCTCTTTGTATTCTCTTCAAGCCCAAACC
AATTCTGTTCCTTCAATCTAAATAGTGGTAATATGAATGTTTAAGAAATGAAATAAGAAACATGTGCAGGCACTTTGGAAGGTGCTAAGT
GACTGCCCTAAGGAATGAAAAGCAAGGGCCAGGTGGGAGTAGCCCAGCGAAGGCACTTGGGCTGCCAGGAACAGGAGGCGTGGGAAACTC
TGGCTTAGGAAAACATGAACACAGGGGCAACAGAGGCAAACTGTTGTTCGAGTTAAATATAAATCTCAGGCTCTTTAAAGGTAAAAGGTT
TAAGGATAATCCATTTGGAAGAAGAAAAGAGTGAGGCTGAAAGTAAAGCCACATGACAAGCATATAAAAAAAAATGCAGATGATACAAAT
ATGAAAGAGGCCTTCAGTGTTTGTTTATTAAGAATCTTAATGCAGTTTACTGATGGATTAAAAACAGCTAACATTGTCTGAAAATTATGT
TACCTATAAGAAGTTGGAAATAAATAAAAGCATAATCACTAGTGATGTGTATGTATTTATATCCACTTGCAAACTGTCCTTGAAGCATGT
GAAAAGGAGTAAGAATACTATCTATGGGTAGCTTTCCTCCCCTTAATGTGAAAAATGAGAACTAAAGCAAAAAGCATCACTCACTGTACA
TATACAATGTATTTTACGTAGTGTAAAAAATATGGTTTAGATAGTGAATATATTAATGAAATCATATGTAAATTTATTTTTAGTGGCTGA
ATAATTTAAAACATTATGTGGAATTCACTATGTTTCCCCCAATTTAGGAACTTTTTACTGTGTGAAAATGAAATTTATAATACTCTGTAG
GGTGAATGATGGTTTTTGCTTTAGTTCTACCCCTCTGTAGAGTTCCAAGGGGTTCTGGTGTAGCTCCAAACAGCAGGAATAACTTTGTCA
GTGCCAAGATTTTATTTAGTTAAAAAACAAAAAATCTACACACTTTACAAGGAACGTTGGCTCCCCTGAGGACTTCCTAGCATTCAACTC
GTTCAGTTAACCCCTATTGCCCATGCTTTGACCTCTCATGCATCTGGCCCCATAGAAACCATGAACCTTGTAACAGATTGATGCCTGAGA
AAAAGTCAATCTACCCGTCCACTCCTCCACTCCCAATACACATACCCCCATGGGCTGTTCTAATTCGGGGGCAGCCAGAGGTAGCCAAGA
ACTCTAAGTCCAGATTCCTTTCACCTCCAGGAACCTAGAGTACATAGTGTGAAAAATACGGTTCAGGCAATGATTATGTTAATGACGCCA
TGCACATTCATTTTTAGTGGCTGAGTAATTTAAAACATGATGTGGGAATTCACTGCATTTCCCCAAATGTAAGAACTTTTTAGTTTTAAA
ATGAAATTTATAGTCACTGTAGAAAATTTGGACACTAAAGTATAAGCAAGTAAAAATCACCCCCAAATTCATCATTCAGAGAAACACTAT
TTTGCTGAACCATTCACTTGACTTGAGTTATATAATTTTATACAGTACATATTATTTTGTAATCTGTGTTTTTGACTTACTTACTTTACC
AAAATAATTTTCTTATGTAAATAATAGAATATAGATTTAGAGTGTTTCAGTTTGTGGAAGCCTCATTTTATTTAACCAATTTCCTATTAA
TGGACATATAGATTTTTAACAATTTTCTACTATTAAAATAATACTGTAATGAATATCACATGCAAACATCATACCACACTCGTCCAGTTA
TTTCTTAGGGTTCTTAACATGGAAGAGGATAAATATATATTTAAAATTTAGATATCTACAGCTTAACCCTCCCAAAGGATTAAACAACTT
ACATTCTCACCAAGGTAGTCCTTTTTTTGCCCTCACCCTCATTGACACTGGATGTTGTCAAATTTAAAAAAAATCCTTAACAATCTGATA
GATGAAAAGATAGTTTAAGTATACTAAGGCAGTGTTTTTCAAGGTGTTTTTGTTTTTGTTTTTGAGTTGGAGTTTTGCTCTGTTGCCCAG
GCTGGAGTGCAGTGGCGCGGTCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTTCCTGCCTCAGCCTCCCGAGTAGCTG
GGACTACAGGCGCGTGCCACCACGCCTGGCTAATTTTTTGTATTTTTATTAGAGACCGACTTAGCCAGGATGGTCTCGATCTCCTGACCT
CTTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCAGCTTTTCAAGTTTCTTAAATCCATGATC
CATAGTAAAAACATTTTACACATATCTTCATACAAGTATATGTATATGTGGTATACGTACACACTATAGTTGTATATGCATTATAGCTGA
AAAACCAGTTCAACCTTTCTACATGTGGTATGTTCCAAAAATTTTAAATGTCTTTCTAAAATGAGGCTCTTTTAATACGGGTATTACTCA
GGCTGTAATAGTGGGAAAATATTTGTTATATGATAAAAGCAGCATATATCATTTCTGTGTAAATGCCAGTATGCTCAAGCCATTTATGCA
GAGAAAAAAAGAAAAACACTGCATTAACATTTTAAGCAGTCCCCTTCCCGATTTGCTATTATACAAAGTTTGTTTCTTTTACATTGTAAA
GTGTATACAACTTATAAAAAGACTATACTCAAAATCATAAAATACCAGTTAACTTAGCTTCTCAGTTTACAGTGGCCAGTGTGGTGTGCT
CTAAACACTGCTGCCTGATCCCTCCCTCTGCTGGTCAGATTTATTACTATAAAGTACCAATCCCATTTGTGTTGTCCTCAATTGGCAATT
ATGAATGGCAGTGCATTAACCATTCAATTCTCACCACTCCATCCCCATTCTTCTACTTCTGGGTCCTTTTGTCCCTCCCTTTCCAGACAG
CCCTTGGTAACCTGCTGCTGGGTAACTAAGGCATCCCACAGGTAGTGTTGAGGTGTTAGGTGATAGAGTAAACCTCTACCTTAATGCTAT
TAACAGGGTCCAAAAATCCAGTTGCATGGAACATGGAGTTATATTATTACATGGCTAATGAAAAGACAGGACTAAGTCTGTTATAGAGTA
TGGGACTAACCCCCAATTATATGTGAATTTGTGTTATCATATGGTTTCAGTGTACTGAGCTAAAAAGCACATTATCTGAGGTGCAATACA

>In-frame_ENST00000306090_ENST00000263593_TCGA-BJ-A192-01A_GNAS_chr20_57486241_-_SIAE_chr11_124543777_length(amino acids)=597AA_start in transcript=1593_stop in transcript=3386
MCCAALKKIKIKIKCEQKKKKTTAAEKGRVQPSPEVAGGCEDCKRVESASPPPRPRPCREPTFPVLGGGQILASMVAPGLVLGLVLPLIL
WADRSAGIGFRFASYINNDMVLQKEPAGAVIWGFGTPGATVTVTLRQGQETIMKKVTSVKAHSDTWMVVLDPMKPGGPFEVMAQQTLEKI
NFTLRVHDVLFGDVWLCSGQSNMQMTVLQIFNATRELSNTAAYQSVRILSVSPIQAEQELEDLVAVDLQWSKPTSENLGHGYFKYMSAVC
WLFGRHLYDTLQYPIGLIASSWGGTPIEAWSSGRSLKACGVPKQGSIPYDSVTGPSKHSVLWNAMIHPLCNMTLKGVVWYQGESNINYNT
DLYNCTFPALIEDWRETFHRGSQGQTERFFPFGLVQLSSDLSKKSSDDGFPQIRWHQTADFGYVPNPKMPNTFMAVAMDLCDRDSPFGSI
HPRDKQTVAYRLHLGARALAYGEKNLTFEGPLPEKIELLAHKGLLNLTYYQQIQVQKKDNKIFEISCCSDHRCKWLPASMNTVSTQSLTL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GNAS-SIAE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GNAS-SIAE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GNAS-SIAE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGNASC3494506Pseudohypoparathyroidism, Type Ia17CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGNASC0242292McCune-Albright Syndrome7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGNASC0016065Polyostotic fibrous dysplasia5CTD_human;ORPHANET
HgeneGNASC1864100PSEUDOHYPOPARATHYROIDISM, TYPE IB5CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneGNASC2931404Albright's hereditary osteodystrophy4CTD_human;GENOMICS_ENGLAND
HgeneGNASC0033806Pseudohypoparathyroidism3CTD_human
HgeneGNASC0334041Osteoma cutis3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGNASC0014130Endocrine System Diseases2CTD_human
HgeneGNASC0016064Fibrous Dysplasia, Monostotic2ORPHANET
HgeneGNASC0034013Precocious Puberty2CTD_human
HgeneGNASC0221263Cafe-au-Lait Spots2CTD_human
HgeneGNASC0271527Cryptogenic sexual precocity2CTD_human
HgeneGNASC0342543Central Precocious Puberty2CTD_human
HgeneGNASC1504412Testotoxicosis2CTD_human
HgeneGNASC1857451Acth-Independent Macronodular Adrenal Hyperplasia2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGNASC2932716Pseudohypoparathyroidism Type 1C2GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGNASC0001206Acromegaly1CTD_human
HgeneGNASC0001624Adrenal Gland Neoplasms1CTD_human
HgeneGNASC0003129Anoxemia1CTD_human
HgeneGNASC0003130Anoxia1CTD_human
HgeneGNASC0008370Cholestasis1GENOMICS_ENGLAND
HgeneGNASC0009438Common Bile Duct Calculi1CTD_human
HgeneGNASC0011573Endogenous depression1PSYGENET
HgeneGNASC0019087Hemorrhagic Disorders1CTD_human
HgeneGNASC0020538Hypertensive disease1CTD_human
HgeneGNASC0020796Profound Mental Retardation1CTD_human
HgeneGNASC0021655Insulin Resistance1CTD_human
HgeneGNASC0023897Liver Diseases, Parasitic1CTD_human
HgeneGNASC0025363Mental Retardation, Psychosocial1CTD_human
HgeneGNASC0027819Neuroblastoma1CTD_human
HgeneGNASC0028754Obesity1CTD_human
HgeneGNASC0029396Heterotopic Ossification1CTD_human
HgeneGNASC0032460Polycystic Ovary Syndrome1CTD_human
HgeneGNASC0033835Pseudopseudohypoparathyroidism1CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneGNASC0035204Respiration Disorders1CTD_human
HgeneGNASC0036341Schizophrenia1PSYGENET
HgeneGNASC0038587Substance Withdrawal Syndrome1CTD_human
HgeneGNASC0039231Tachycardia1CTD_human
HgeneGNASC0080203Tachyarrhythmia1CTD_human
HgeneGNASC0086189Drug Withdrawal Symptoms1CTD_human
HgeneGNASC0087169Withdrawal Symptoms1CTD_human
HgeneGNASC0206698Cholangiocarcinoma1CTD_human
HgeneGNASC0221357Brachydactyly1CTD_human
HgeneGNASC0242184Hypoxia1CTD_human
HgeneGNASC0242216Biliary calculi1CTD_human
HgeneGNASC0345905Intrahepatic Cholangiocarcinoma1CTD_human
HgeneGNASC0346302Growth Hormone-Secreting Pituitary Adenoma1CTD_human
HgeneGNASC0700292Hypoxemia1CTD_human
HgeneGNASC0750887Adrenal Cancer1CTD_human
HgeneGNASC0917816Mental deficiency1CTD_human
HgeneGNASC0920563Insulin Sensitivity1CTD_human
HgeneGNASC1136382Sclerocystic Ovaries1CTD_human
HgeneGNASC2932715Pseudohypoparathyroidism Type 1B1CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneGNASC3489630Somatotrophinoma, Familial1CTD_human
HgeneGNASC3697137Fibrous dysplasia of bone with intramuscular myxoma1ORPHANET
HgeneGNASC3714756Intellectual Disability1CTD_human
HgeneGNASC3805278Extrahepatic Cholangiocarcinoma1CTD_human
TgeneSIAEC3150797AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 61UNIPROT