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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GOLGA4-HSPA8 (FusionGDB2 ID:33780)

Fusion Gene Summary for GOLGA4-HSPA8

check button Fusion gene summary
Fusion gene informationFusion gene name: GOLGA4-HSPA8
Fusion gene ID: 33780
HgeneTgene
Gene symbol

GOLGA4

HSPA8

Gene ID

2803

3312

Gene namegolgin A4heat shock protein family A (Hsp70) member 8
SynonymsCRPF46|GCP2|GOLG|MU-RMS-40.18|p230HEL-33|HEL-S-72p|HSC54|HSC70|HSC71|HSP71|HSP73|HSPA10|LAP-1|LAP1|NIP71
Cytomap

3p22.2

11q24.1

Type of geneprotein-codingprotein-coding
Descriptiongolgin subfamily A member 4256 kDa golgin72.1 proteincentrosome-related protein F46golgi autoantigen, golgin subfamily a, 4golgin-240golgin-245protein 72.1trans-Golgi p230heat shock cognate 71 kDa proteinLPS-associated protein 1N-myristoyltransferase inhibitor protein 71constitutive heat shock protein 70epididymis luminal protein 33epididymis secretory sperm binding protein Li 72pheat shock 70kDa protein 8heat shock
Modification date2020031320200327
UniProtAcc.

P11142

Ensembl transtripts involved in fusion geneENST00000361924, ENST00000435830, 
ENST00000444882, ENST00000356847, 
ENST00000532636, ENST00000533540, 
ENST00000453788, ENST00000534624, 
ENST00000227378, ENST00000534319, 
ENST00000526110, ENST00000526862, 
Fusion gene scores* DoF score24 X 16 X 11=422420 X 20 X 4=1600
# samples 2723
** MAII scorelog2(27/4224*10)=-3.96757852230762
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/1600*10)=-2.79836613883035
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GOLGA4 [Title/Abstract] AND HSPA8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGOLGA4(37292975)-HSPA8(122930976), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGOLGA4

GO:0043001

Golgi to plasma membrane protein transport

15265687

HgeneGOLGA4

GO:0045773

positive regulation of axon extension

22705394

TgeneHSPA8

GO:0042026

protein refolding

21231916|25719862

TgeneHSPA8

GO:0045892

negative regulation of transcription, DNA-templated

10722728

TgeneHSPA8

GO:0046034

ATP metabolic process

23921388

TgeneHSPA8

GO:1902904

negative regulation of supramolecular fiber organization

23921388


check buttonFusion gene breakpoints across GOLGA4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HSPA8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-GM-A2DFGOLGA4chr3

37292975

+HSPA8chr11

122930976

-
ChimerDB4BRCATCGA-GM-A2DF-01AGOLGA4chr3

37292975

+HSPA8chr11

122930976

-
ChimerDB4BRCATCGA-GM-A2DF-01AGOLGA4chr3

37292975

-HSPA8chr11

122930976

-


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Fusion Gene ORF analysis for GOLGA4-HSPA8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000361924ENST00000532636GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000361924ENST00000533540GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000361924ENST00000453788GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000361924ENST00000534624GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000361924ENST00000227378GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-5UTRENST00000361924ENST00000534319GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000361924ENST00000526110GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000361924ENST00000526862GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
intron-3CDSENST00000435830ENST00000532636GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
intron-intronENST00000435830ENST00000533540GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
intron-intronENST00000435830ENST00000453788GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
intron-intronENST00000435830ENST00000534624GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
intron-intronENST00000435830ENST00000227378GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
intron-5UTRENST00000435830ENST00000534319GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
intron-intronENST00000435830ENST00000526110GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
intron-intronENST00000435830ENST00000526862GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
In-frameENST00000444882ENST00000532636GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000444882ENST00000533540GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000444882ENST00000453788GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000444882ENST00000534624GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000444882ENST00000227378GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-5UTRENST00000444882ENST00000534319GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000444882ENST00000526110GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000444882ENST00000526862GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
In-frameENST00000356847ENST00000532636GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000356847ENST00000533540GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000356847ENST00000453788GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000356847ENST00000534624GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000356847ENST00000227378GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-5UTRENST00000356847ENST00000534319GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000356847ENST00000526110GOLGA4chr3

37292975

+HSPA8chr11

122930976

-
5CDS-intronENST00000356847ENST00000526862GOLGA4chr3

37292975

+HSPA8chr11

122930976

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361924GOLGA4chr337292975+ENST00000532636HSPA8chr11122930976-23115363742065563
ENST00000444882GOLGA4chr337292975+ENST00000532636HSPA8chr11122930976-22414663041995563
ENST00000356847GOLGA4chr337292975+ENST00000532636HSPA8chr11122930976-22364612991990563

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361924ENST00000532636GOLGA4chr337292975+HSPA8chr11122930976-0.002679510.9973205
ENST00000444882ENST00000532636GOLGA4chr337292975+HSPA8chr11122930976-0.0030683540.9969317
ENST00000356847ENST00000532636GOLGA4chr337292975+HSPA8chr11122930976-0.0030913950.9969086

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Fusion Genomic Features for GOLGA4-HSPA8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GOLGA4-HSPA8


check button Go to

FGviewer for the breakpoints of chr3:37292975-chr11:122930976

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HSPA8

P11142

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488, PubMed:12526792). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488, PubMed:12526792). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24318877, PubMed:27474739, PubMed:24121476, PubMed:26865365). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). Interacts with VGF-derived peptide TLQP-21 (PubMed:28934328). {ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:28934328, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHSPA8chr3:37292975chr11:122930976ENST0000022737818202_204137.0647.0Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST0000022737818268_275137.0647.0Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST0000045378828202_204137.0494.0Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST0000045378828268_275137.0494.0Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST0000053263629202_204137.0647.0Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST0000053263629268_275137.0647.0Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST0000053462429202_204137.0647.0Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST0000053462429268_275137.0647.0Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST0000022737818394_509137.0647.0RegionSubstrate-binding domain (SBD)
TgeneHSPA8chr3:37292975chr11:122930976ENST0000045378828394_509137.0494.0RegionSubstrate-binding domain (SBD)
TgeneHSPA8chr3:37292975chr11:122930976ENST0000053263629394_509137.0647.0RegionSubstrate-binding domain (SBD)
TgeneHSPA8chr3:37292975chr11:122930976ENST0000053462429394_509137.0647.0RegionSubstrate-binding domain (SBD)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGOLGA4chr3:37292975chr11:122930976ENST00000356847+223133_218554.02244.0Coiled coilOntology_term=ECO:0000255
HgeneGOLGA4chr3:37292975chr11:122930976ENST00000361924+224133_218554.02306.3333333333335Coiled coilOntology_term=ECO:0000255
HgeneGOLGA4chr3:37292975chr11:122930976ENST00000356847+223252_209654.02244.0Compositional biasNote=Glu-rich
HgeneGOLGA4chr3:37292975chr11:122930976ENST00000361924+224252_209654.02306.3333333333335Compositional biasNote=Glu-rich
HgeneGOLGA4chr3:37292975chr11:122930976ENST00000356847+2232168_221554.02244.0DomainGRIP
HgeneGOLGA4chr3:37292975chr11:122930976ENST00000361924+2242168_221554.02306.3333333333335DomainGRIP
TgeneHSPA8chr3:37292975chr11:122930976ENST000002273781812_15137.0647.0Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST000004537882812_15137.0494.0Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST000005326362912_15137.0647.0Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST000005346242912_15137.0647.0Nucleotide bindingNote=ATP
TgeneHSPA8chr3:37292975chr11:122930976ENST00000227378182_386137.0647.0RegionNucleotide-binding domain (NBD)
TgeneHSPA8chr3:37292975chr11:122930976ENST00000453788282_386137.0494.0RegionNucleotide-binding domain (NBD)
TgeneHSPA8chr3:37292975chr11:122930976ENST00000532636292_386137.0647.0RegionNucleotide-binding domain (NBD)
TgeneHSPA8chr3:37292975chr11:122930976ENST00000534624292_386137.0647.0RegionNucleotide-binding domain (NBD)


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Fusion Gene Sequence for GOLGA4-HSPA8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000361924_ENST00000532636_TCGA-GM-A2DF_GOLGA4_chr3_37292975_+_HSPA8_chr11_122930976_length(transcript)=2311nt_BP=536nt
ATGTGCGGGACCCGACATTGTGCTTGTCCCATCCGGTGCTCCGTAGTTAGCCTCTGTGAGCTCCACGTAGGCCGCGCAAGCGCCCTTGGC
GCACAGTTCACCTGCTGCCGTTGTCGTCGCCGCCGCGGCTCCCGGGGCTGGATGGGGGGCCGAGGCCAGCCAGTGGCACCCGGAAGAAAG
AGACGCGGCGGCGGCGACGCCGACACCCTCAGGACGAGTGTCCGGACTTGCCCACAGCCTCAAGGAGGAGACGGCGAGGCCCGGCCCCCG
CTGTCCCTGGTGTAAAGAAGTCGCCGTAGCCGTCGCGGCCGGGACTCCCCGGGCTCTCGCCCTTCAGGTTTCGTTGACACTCAGGACCGT
ACGTACGCTGCGCCATGTTCAAGAAACTGAAGCAAAAGATCAGCGAGGAGCAGCAGCAGCTCCAGCAGGCGCTGGCTCCTGCTCAGGCGT
CCTCCAATTCTTCAACACCAACAAGAATGAGGAGCAGGACATCTTCATTTACAGAGCAACTTGATGAAGGTACACCCAATAGAGAGACTG
TTACCAATGCTGTGGTCACAGTGCCAGCTTACTTTAATGACTCTCAGCGTCAGGCTACCAAAGATGCTGGAACTATTGCTGGTCTCAATG
TACTTAGAATTATTAATGAGCCAACTGCTGCTGCTATTGCTTACGGCTTAGACAAAAAGGTTGGAGCAGAAAGAAACGTGCTCATCTTTG
ACCTGGGAGGTGGCACTTTTGATGTGTCAATCCTCACTATTGAGGATGGAATCTTTGAGGTCAAGTCTACAGCTGGAGACACCCACTTGG
GTGGAGAAGATTTTGACAACCGAATGGTCAACCATTTTATTGCTGAGTTTAAGCGCAAGCATAAGAAGGACATCAGTGAGAACAAGAGAG
CTGTAAGACGCCTCCGTACTGCTTGTGAACGTGCTAAGCGTACCCTCTCTTCCAGCACCCAGGCCAGTATTGAGATCGATTCTCTCTATG
AAGGAATCGACTTCTATACCTCCATTACCCGTGCCCGATTTGAAGAACTGAATGCTGACCTGTTCCGTGGCACCCTGGACCCAGTAGAGA
AAGCCCTTCGAGATGCCAAACTAGACAAGTCACAGATTCATGATATTGTCCTGGTTGGTGGTTCTACTCGTATCCCCAAGATTCAGAAGC
TTCTCCAAGACTTCTTCAATGGAAAAGAACTGAATAAGAGCATCAACCCTGATGAAGCTGTTGCTTATGGTGCAGCTGTCCAGGCAGCCA
TCTTGTCTGGAGACAAGTCTGAGAATGTTCAAGATTTGCTGCTCTTGGATGTCACTCCTCTTTCCCTTGGTATTGAAACTGCTGGTGGAG
TCATGACTGTCCTCATCAAGCGTAATACCACCATTCCTACCAAGCAGACACAGACCTTCACTACCTATTCTGACAACCAGCCTGGTGTGC
TTATTCAGGTTTATGAAGGCGAGCGTGCCATGACAAAGGATAACAACCTGCTTGGCAAGTTTGAACTCACAGGCATACCTCCTGCACCCC
GAGGTGTTCCTCAGATTGAAGTCACTTTTGACATTGATGCCAATGGTATACTCAATGTCTCTGCTGTGGACAAGAGTACGGGAAAAGAGA
ACAAGATTACTATCACTAATGACAAGGGCCGTTTGAGCAAGGAAGACATTGAACGTATGGTCCAGGAAGCTGAGAAGTACAAAGCTGAAG
ATGAGAAGCAGAGGGACAAGGTGTCATCCAAGAATTCACTTGAGTCCTATGCCTTCAACATGAAAGCAACTGTTGAAGATGAGAAACTTC
AAGGCAAGATTAACGATGAGGACAAACAGAAGATTCTGGACAAGTGTAATGAAATTATCAACTGGCTTGATAAGAATCAGACTGCTGAGA
AGGAAGAATTTGAACATCAACAGAAAGAGCTGGAGAAAGTTTGCAACCCCATCATCACCAAGCTGTACCAGAGTGCAGGAGGCATGCCAG
GAGGAATGCCTGGGGGATTTCCTGGTGGTGGAGCTCCTCCCTCTGGTGGTGCTTCCTCAGGGCCCACCATTGAAGAGGTTGATTAAGCCA
ACCAAGTGTAGATGTAGCATTGTTCCACACATTTAAAACATTTGAAGGACCTAAATTCGTAGCAAATTCTGTGGCAGTTTTAAAAAGTTA
AGCTGCTATAGTAAGTTACTGGGCATTCTCAATACTTGAATATGGAACATATGCACAGGGGAAGGAAATAACATTGCACTTTATAAACAC

>In-frame_ENST00000361924_ENST00000532636_TCGA-GM-A2DF_GOLGA4_chr3_37292975_+_HSPA8_chr11_122930976_length(amino acids)=563AA_start in transcript=374_stop in transcript=2065
MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRETVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRII
NEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRL
RTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDF
FNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVY
EGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQR
DKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPG

--------------------------------------------------------------
>In-frame_ENST00000444882_ENST00000532636_TCGA-GM-A2DF_GOLGA4_chr3_37292975_+_HSPA8_chr11_122930976_length(transcript)=2241nt_BP=466nt
GCCGCGCAAGCGCCCTTGGCGCACAGTTCACCTGCTGCCGTTGTCGTCGCCGCCGCGGCTCCCGGGGCTGGATGGGGGGCCGAGGCCAGC
CAGTGGCACCCGGAAGAAAGAGACGCGGCGGCGGCGACGCCGACACCCTCAGGACGAGTGTCCGGACTTGCCCACAGCCTCAAGGAGGAG
ACGGCGAGGCCCGGCCCCCGCTGTCCCTGGTGTAAAGAAGTCGCCGTAGCCGTCGCGGCCGGGACTCCCCGGGCTCTCGCCCTTCAGGTT
TCGTTGACACTCAGGACCGTACGTACGCTGCGCCATGTTCAAGAAACTGAAGCAAAAGATCAGCGAGGAGCAGCAGCAGCTCCAGCAGGC
GCTGGCTCCTGCTCAGGCGTCCTCCAATTCTTCAACACCAACAAGAATGAGGAGCAGGACATCTTCATTTACAGAGCAACTTGATGAAGG
TACACCCAATAGAGAGACTGTTACCAATGCTGTGGTCACAGTGCCAGCTTACTTTAATGACTCTCAGCGTCAGGCTACCAAAGATGCTGG
AACTATTGCTGGTCTCAATGTACTTAGAATTATTAATGAGCCAACTGCTGCTGCTATTGCTTACGGCTTAGACAAAAAGGTTGGAGCAGA
AAGAAACGTGCTCATCTTTGACCTGGGAGGTGGCACTTTTGATGTGTCAATCCTCACTATTGAGGATGGAATCTTTGAGGTCAAGTCTAC
AGCTGGAGACACCCACTTGGGTGGAGAAGATTTTGACAACCGAATGGTCAACCATTTTATTGCTGAGTTTAAGCGCAAGCATAAGAAGGA
CATCAGTGAGAACAAGAGAGCTGTAAGACGCCTCCGTACTGCTTGTGAACGTGCTAAGCGTACCCTCTCTTCCAGCACCCAGGCCAGTAT
TGAGATCGATTCTCTCTATGAAGGAATCGACTTCTATACCTCCATTACCCGTGCCCGATTTGAAGAACTGAATGCTGACCTGTTCCGTGG
CACCCTGGACCCAGTAGAGAAAGCCCTTCGAGATGCCAAACTAGACAAGTCACAGATTCATGATATTGTCCTGGTTGGTGGTTCTACTCG
TATCCCCAAGATTCAGAAGCTTCTCCAAGACTTCTTCAATGGAAAAGAACTGAATAAGAGCATCAACCCTGATGAAGCTGTTGCTTATGG
TGCAGCTGTCCAGGCAGCCATCTTGTCTGGAGACAAGTCTGAGAATGTTCAAGATTTGCTGCTCTTGGATGTCACTCCTCTTTCCCTTGG
TATTGAAACTGCTGGTGGAGTCATGACTGTCCTCATCAAGCGTAATACCACCATTCCTACCAAGCAGACACAGACCTTCACTACCTATTC
TGACAACCAGCCTGGTGTGCTTATTCAGGTTTATGAAGGCGAGCGTGCCATGACAAAGGATAACAACCTGCTTGGCAAGTTTGAACTCAC
AGGCATACCTCCTGCACCCCGAGGTGTTCCTCAGATTGAAGTCACTTTTGACATTGATGCCAATGGTATACTCAATGTCTCTGCTGTGGA
CAAGAGTACGGGAAAAGAGAACAAGATTACTATCACTAATGACAAGGGCCGTTTGAGCAAGGAAGACATTGAACGTATGGTCCAGGAAGC
TGAGAAGTACAAAGCTGAAGATGAGAAGCAGAGGGACAAGGTGTCATCCAAGAATTCACTTGAGTCCTATGCCTTCAACATGAAAGCAAC
TGTTGAAGATGAGAAACTTCAAGGCAAGATTAACGATGAGGACAAACAGAAGATTCTGGACAAGTGTAATGAAATTATCAACTGGCTTGA
TAAGAATCAGACTGCTGAGAAGGAAGAATTTGAACATCAACAGAAAGAGCTGGAGAAAGTTTGCAACCCCATCATCACCAAGCTGTACCA
GAGTGCAGGAGGCATGCCAGGAGGAATGCCTGGGGGATTTCCTGGTGGTGGAGCTCCTCCCTCTGGTGGTGCTTCCTCAGGGCCCACCAT
TGAAGAGGTTGATTAAGCCAACCAAGTGTAGATGTAGCATTGTTCCACACATTTAAAACATTTGAAGGACCTAAATTCGTAGCAAATTCT
GTGGCAGTTTTAAAAAGTTAAGCTGCTATAGTAAGTTACTGGGCATTCTCAATACTTGAATATGGAACATATGCACAGGGGAAGGAAATA

>In-frame_ENST00000444882_ENST00000532636_TCGA-GM-A2DF_GOLGA4_chr3_37292975_+_HSPA8_chr11_122930976_length(amino acids)=563AA_start in transcript=304_stop in transcript=1995
MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRETVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRII
NEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRL
RTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDF
FNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVY
EGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQR
DKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPG

--------------------------------------------------------------
>In-frame_ENST00000356847_ENST00000532636_TCGA-GM-A2DF_GOLGA4_chr3_37292975_+_HSPA8_chr11_122930976_length(transcript)=2236nt_BP=461nt
GCAAGCGCCCTTGGCGCACAGTTCACCTGCTGCCGTTGTCGTCGCCGCCGCGGCTCCCGGGGCTGGATGGGGGGCCGAGGCCAGCCAGTG
GCACCCGGAAGAAAGAGACGCGGCGGCGGCGACGCCGACACCCTCAGGACGAGTGTCCGGACTTGCCCACAGCCTCAAGGAGGAGACGGC
GAGGCCCGGCCCCCGCTGTCCCTGGTGTAAAGAAGTCGCCGTAGCCGTCGCGGCCGGGACTCCCCGGGCTCTCGCCCTTCAGGTTTCGTT
GACACTCAGGACCGTACGTACGCTGCGCCATGTTCAAGAAACTGAAGCAAAAGATCAGCGAGGAGCAGCAGCAGCTCCAGCAGGCGCTGG
CTCCTGCTCAGGCGTCCTCCAATTCTTCAACACCAACAAGAATGAGGAGCAGGACATCTTCATTTACAGAGCAACTTGATGAAGGTACAC
CCAATAGAGAGACTGTTACCAATGCTGTGGTCACAGTGCCAGCTTACTTTAATGACTCTCAGCGTCAGGCTACCAAAGATGCTGGAACTA
TTGCTGGTCTCAATGTACTTAGAATTATTAATGAGCCAACTGCTGCTGCTATTGCTTACGGCTTAGACAAAAAGGTTGGAGCAGAAAGAA
ACGTGCTCATCTTTGACCTGGGAGGTGGCACTTTTGATGTGTCAATCCTCACTATTGAGGATGGAATCTTTGAGGTCAAGTCTACAGCTG
GAGACACCCACTTGGGTGGAGAAGATTTTGACAACCGAATGGTCAACCATTTTATTGCTGAGTTTAAGCGCAAGCATAAGAAGGACATCA
GTGAGAACAAGAGAGCTGTAAGACGCCTCCGTACTGCTTGTGAACGTGCTAAGCGTACCCTCTCTTCCAGCACCCAGGCCAGTATTGAGA
TCGATTCTCTCTATGAAGGAATCGACTTCTATACCTCCATTACCCGTGCCCGATTTGAAGAACTGAATGCTGACCTGTTCCGTGGCACCC
TGGACCCAGTAGAGAAAGCCCTTCGAGATGCCAAACTAGACAAGTCACAGATTCATGATATTGTCCTGGTTGGTGGTTCTACTCGTATCC
CCAAGATTCAGAAGCTTCTCCAAGACTTCTTCAATGGAAAAGAACTGAATAAGAGCATCAACCCTGATGAAGCTGTTGCTTATGGTGCAG
CTGTCCAGGCAGCCATCTTGTCTGGAGACAAGTCTGAGAATGTTCAAGATTTGCTGCTCTTGGATGTCACTCCTCTTTCCCTTGGTATTG
AAACTGCTGGTGGAGTCATGACTGTCCTCATCAAGCGTAATACCACCATTCCTACCAAGCAGACACAGACCTTCACTACCTATTCTGACA
ACCAGCCTGGTGTGCTTATTCAGGTTTATGAAGGCGAGCGTGCCATGACAAAGGATAACAACCTGCTTGGCAAGTTTGAACTCACAGGCA
TACCTCCTGCACCCCGAGGTGTTCCTCAGATTGAAGTCACTTTTGACATTGATGCCAATGGTATACTCAATGTCTCTGCTGTGGACAAGA
GTACGGGAAAAGAGAACAAGATTACTATCACTAATGACAAGGGCCGTTTGAGCAAGGAAGACATTGAACGTATGGTCCAGGAAGCTGAGA
AGTACAAAGCTGAAGATGAGAAGCAGAGGGACAAGGTGTCATCCAAGAATTCACTTGAGTCCTATGCCTTCAACATGAAAGCAACTGTTG
AAGATGAGAAACTTCAAGGCAAGATTAACGATGAGGACAAACAGAAGATTCTGGACAAGTGTAATGAAATTATCAACTGGCTTGATAAGA
ATCAGACTGCTGAGAAGGAAGAATTTGAACATCAACAGAAAGAGCTGGAGAAAGTTTGCAACCCCATCATCACCAAGCTGTACCAGAGTG
CAGGAGGCATGCCAGGAGGAATGCCTGGGGGATTTCCTGGTGGTGGAGCTCCTCCCTCTGGTGGTGCTTCCTCAGGGCCCACCATTGAAG
AGGTTGATTAAGCCAACCAAGTGTAGATGTAGCATTGTTCCACACATTTAAAACATTTGAAGGACCTAAATTCGTAGCAAATTCTGTGGC
AGTTTTAAAAAGTTAAGCTGCTATAGTAAGTTACTGGGCATTCTCAATACTTGAATATGGAACATATGCACAGGGGAAGGAAATAACATT

>In-frame_ENST00000356847_ENST00000532636_TCGA-GM-A2DF_GOLGA4_chr3_37292975_+_HSPA8_chr11_122930976_length(amino acids)=563AA_start in transcript=299_stop in transcript=1990
MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRETVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRII
NEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRL
RTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDF
FNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVY
EGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQR
DKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GOLGA4-HSPA8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneHSPA8chr3:37292975chr11:122930976ENST0000022737818186_377137.0647.0BAG1
TgeneHSPA8chr3:37292975chr11:122930976ENST0000045378828186_377137.0494.0BAG1
TgeneHSPA8chr3:37292975chr11:122930976ENST0000053263629186_377137.0647.0BAG1
TgeneHSPA8chr3:37292975chr11:122930976ENST0000053462429186_377137.0647.0BAG1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneGOLGA4chr3:37292975chr11:122930976ENST00000356847+223133_20354.02244.0MACF1
HgeneGOLGA4chr3:37292975chr11:122930976ENST00000361924+224133_20354.02306.3333333333335MACF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GOLGA4-HSPA8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneHSPA8P11142DB01254DasatinibSmall moleculeApproved|Investigational
TgeneHSPA8P11142DB01254DasatinibSmall moleculeApproved|Investigational
TgeneHSPA8P11142DB01254DasatinibSmall moleculeApproved|Investigational
TgeneHSPA8P11142DB01254DasatinibSmall moleculeApproved|Investigational
TgeneHSPA8P11142DB09130CopperSmall moleculeApproved|Investigational
TgeneHSPA8P11142DB09130CopperSmall moleculeApproved|Investigational
TgeneHSPA8P11142DB09130CopperSmall moleculeApproved|Investigational
TgeneHSPA8P11142DB09130CopperSmall moleculeApproved|Investigational

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Related Diseases for GOLGA4-HSPA8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGOLGA4C0033578Prostatic Neoplasms1CTD_human
HgeneGOLGA4C0037274Dermatologic disorders1CTD_human
HgeneGOLGA4C0274861Arsenic Poisoning, Inorganic1CTD_human
HgeneGOLGA4C0274862Nervous System, Organic Arsenic Poisoning1CTD_human
HgeneGOLGA4C0311375Arsenic Poisoning1CTD_human
HgeneGOLGA4C0376358Malignant neoplasm of prostate1CTD_human
HgeneGOLGA4C0751851Arsenic Encephalopathy1CTD_human
HgeneGOLGA4C0751852Arsenic Induced Polyneuropathy1CTD_human
TgeneHSPA8C0001418Adenocarcinoma1CTD_human
TgeneHSPA8C0007137Squamous cell carcinoma1CTD_human
TgeneHSPA8C0024623Malignant neoplasm of stomach1CTD_human
TgeneHSPA8C0026640Mouth Neoplasms1CTD_human
TgeneHSPA8C0035126Reperfusion Injury1CTD_human
TgeneHSPA8C0038356Stomach Neoplasms1CTD_human
TgeneHSPA8C0153381Malignant neoplasm of mouth1CTD_human
TgeneHSPA8C0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneHSPA8C0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneHSPA8C0205643Carcinoma, Cribriform1CTD_human
TgeneHSPA8C0205644Carcinoma, Granular Cell1CTD_human
TgeneHSPA8C0205645Adenocarcinoma, Tubular1CTD_human
TgeneHSPA8C0948089Acute Coronary Syndrome1CTD_human
TgeneHSPA8C1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneHSPA8C1846707SPINOCEREBELLAR ATAXIA 171CTD_human