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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKAP10-GID4 (FusionGDB2 ID:3387)

Fusion Gene Summary for AKAP10-GID4

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP10-GID4
Fusion gene ID: 3387
HgeneTgene
Gene symbol

AKAP10

GID4

Gene ID

11216

79018

Gene nameA-kinase anchoring protein 10GID complex subunit 4 homolog
SynonymsAKAP-10|D-AKAP-2|D-AKAP2|PRKA10C17orf39|VID2|VID24
Cytomap

17p11.2

17p11.2|17p11.2

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 10, mitochondrialA kinase (PRKA) anchor protein 10A kinase anchor protein 10dual specificity A kinase-anchoring protein 2mitochondrial A kinase PPKA anchor protein 10protein kinase A anchoring protein 10glucose-induced degradation protein 4 homologGID complex subunit 4, VID24 homologvacuolar import and degradation 24vacuolar import and degradation protein 24 homolog
Modification date2020031320200313
UniProtAcc.

Q8IVV7

Ensembl transtripts involved in fusion geneENST00000225737, ENST00000395536, 
ENST00000572155, 		ENST00000268719, 
ENST00000376345, ENST00000579871, 
Fusion gene scores* DoF score6 X 6 X 4=1444 X 3 X 4=48
# samples 64
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKAP10 [Title/Abstract] AND GID4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKAP10(19839599)-GID4(17962182), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AKAP10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GID4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YL-A9WY-01AAKAP10chr17

19839599

-GID4chr17

17962182

+
ChimerDB4PRADTCGA-YL-A9WYAKAP10chr17

19839599

-GID4chr17

17962182

+


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Fusion Gene ORF analysis for AKAP10-GID4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000225737ENST00000268719AKAP10chr17

19839599

-GID4chr17

17962182

+
5CDS-intronENST00000225737ENST00000376345AKAP10chr17

19839599

-GID4chr17

17962182

+
5CDS-intronENST00000225737ENST00000579871AKAP10chr17

19839599

-GID4chr17

17962182

+
In-frameENST00000395536ENST00000268719AKAP10chr17

19839599

-GID4chr17

17962182

+
5CDS-intronENST00000395536ENST00000376345AKAP10chr17

19839599

-GID4chr17

17962182

+
5CDS-intronENST00000395536ENST00000579871AKAP10chr17

19839599

-GID4chr17

17962182

+
intron-3CDSENST00000572155ENST00000268719AKAP10chr17

19839599

-GID4chr17

17962182

+
intron-intronENST00000572155ENST00000376345AKAP10chr17

19839599

-GID4chr17

17962182

+
intron-intronENST00000572155ENST00000579871AKAP10chr17

19839599

-GID4chr17

17962182

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000225737AKAP10chr1719839599-ENST00000268719GID4chr1717962182+508316251581921587
ENST00000395536AKAP10chr1719839599-ENST00000268719GID4chr1717962182+4925146701763587

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000225737ENST00000268719AKAP10chr1719839599-GID4chr1717962182+0.0015034370.99849653
ENST00000395536ENST00000268719AKAP10chr1719839599-GID4chr1717962182+0.0014275180.99857247

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Fusion Genomic Features for AKAP10-GID4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AKAP10chr1719839598-GID4chr1717962181+0.0094133680.9905867
AKAP10chr1719839598-GID4chr1717962181+0.0094133680.9905867
AKAP10chr1719839598-GID4chr1717962181+0.0094133680.9905867
AKAP10chr1719839598-GID4chr1717962181+0.0094133680.9905867

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AKAP10-GID4


check button Go to

FGviewer for the breakpoints of chr17:19839599-chr17:17962182

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GID4

Q8IVV7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Substrate-recognition subunit of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (Probable) (PubMed:29911972). Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly-Leu-Trp (PubMed:29632410). Binds peptides with an N-terminal sequence of the type Pro-[Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind peptides with an acetylated N-terminal Pro residue (PubMed:29632410). {ECO:0000269|PubMed:29632410, ECO:0000269|PubMed:29911972, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKAP10chr17:19839599chr17:17962182ENST00000225737-915125_369489.0663.0DomainRGS 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKAP10chr17:19839599chr17:17962182ENST00000225737-915379_505489.0663.0DomainRGS 2
HgeneAKAP10chr17:19839599chr17:17962182ENST00000225737-915634_647489.0663.0RegionNote=PKA-RII subunit binding
TgeneGID4chr17:19839599chr17:17962182ENST000002687192642_109202.0301.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for AKAP10-GID4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000225737_ENST00000268719_TCGA-YL-A9WY-01A_AKAP10_chr17_19839599_-_GID4_chr17_17962182_length(transcript)=5083nt_BP=1625nt
AAGGACCGGAACTCCGGGCGGGCGGCTTGTTGATAATATGGCGGCTGGAGCTGCCTGGGCATCCCGAGGAGGCGGTGGGGCCCACTCCCG
GAAGAAGGGTCCCTTTTCGCGCTAGTGCAGCGGCCCCTCTGGACCCGGAAGTCCGGGCCGGTTGCTGAATGAGGGGAGCCGGGCCCTCCC
CGCGCCAGTCCCCCCGCACCCTCCGTCCCGACCCGGGCCCCGCCATGTCCTTCTTCCGGCGGAAAGTGAAAGGCAAAGAACAAGAGAAGA
CCTCAGATGTGAAGTCCATTAAAGCTTCAATATCCGTACATTCCCCACAAAAAAGCACTAAAAATCATGCCTTGCTGGAGGCTGCAGGAC
CAAGTCATGTTGCAATCAATGCCATTTCTGCCAACATGGACTCCTTTTCAAGTAGCAGGACAGCCACACTTAAGAAGCAGCCAAGCCACA
TGGAGGCCGCTCATTTTGGTGACCTGGGCAGATCTTGTCTGGACTACCAGACTCAAGAGACCAAATCAAGCCTTTCTAAGACCCTTGAAC
AAGTCTTGCACGACACTATTGTCCTCCCTTACTTCATTCAATTCATGGAACTTCGGCGAATGGAGCATTTGGTGAAATTTTGGTTAGAGG
CTGAAAGTTTTCATTCAACAACTTGGTCGCGAATAAGAGCACACAGTCTAAACACAGTGAAGCAGAGCTCACTGGCTGAGCCTGTCTCTC
CATCTAAAAAGCATGAAACTACAGCGTCTTTTTTAACTGATTCTCTTGATAAGAGATTGGAGGATTCTGGCTCAGCACAGTTGTTTATGA
CTCATTCAGAAGGAATTGACCTGAATAATAGAACTAACAGCACTCAGAATCACTTGCTGCTTTCCCAGGAATGTGACAGTGCCCATTCTC
TCCGTCTTGAAATGGCCAGAGCAGGAACTCACCAAGTTTCCATGGAAACCCAAGAATCTTCCTCTACACTTACAGTAGCCAGTAGAAATA
GTCCCGCTTCTCCACTAAAAGAATTGTCAGGAAAACTAATGAAAAGTATAGAACAAGATGCAGTGAATACTTTTACCAAATATATATCTC
CAGATGCTGCTAAACCAATACCAATTACAGAAGCAATGAGAAATGACATCATAGCAAGGATTTGTGGAGAAGATGGACAGGTGGATCCCA
ACTGTTTCGTTTTGGCACAGTCCATAGTCTTTAGTGCAATGGAGCAAGAGCACTTTAGTGAGTTTCTGCGAAGTCACCATTTCTGTAAAT
ACCAGATTGAAGTGCTGACCAGTGGAACTGTTTACCTGGCTGACATTCTCTTCTGTGAGTCAGCCCTCTTTTATTTCTCTGAGTACATGG
AAAAAGAGGATGCAGTGAATATCTTACAATTCTGGTTGGCAGCAGATAACTTCCAGTCTCAGCTTGCTGCCAAAAAGGGCCAATATGATG
GACAGGAGGCACAGAATGATGCCATGATTTTATATGACAAGTACTTCTCCCTCCAAGCCACACATCCTCTTGGATTTGATGATGTTGTAC
GATTAGAAATTGAATCCAATATCTGCAGGGAAGGTGGGCCACTCCCCAACTGTTTCACAACTCCATTACGTCAGGCCTGGACAACCATGG
AGAAGGGCAAGTTTCTGGCTTTTTATCAGTATGCAAAATCATTTAACTCAGATGACTTTGATTATGAAGAGCTGAAGAATGGAGACTACG
TCTTCATGAGGTGGAAGGAACAGTTTCTGGTCCCAGATCACACGATCAAAGACATCAGTGGTGCTTCTTTTGCCGGGTTCTACTACATCT
GCTTTCAGAAGTCAGCAGCCTCCATAGAGGGCTACTACTACCATAGGAGTTCAGAATGGTATCAGTCCCTCAATCTAACCCATGTTCCTG
AACACAGTGCACCCATCTATGAATTCCGGTGACAACGGTTCAGAACAGCAACCAAATAAAACTGAACTTGGCAAAAAAGAACTTTGCCGA
GAAAATTGTGTACCTGCCAGAACCAGGAGAAGTGTGTTCCTGTTTCTTCACGAGCAGACTCGCATCACAAAGCATGAATGTTAACCCACA
GAATCCAAGGAGCATGGCTGGCCCGTGGGGCAGGTGGAGGGAGCAGTCTTCGTTCTTCCTCCCCTCAGTGGCAGTTTGGTCTTCACCTGT
TTTTAAGCTACCTTAAACGCACTTTTCCTTCCTGCACAGCTAACTTCTACATCACTGAAATGCCCATTCCTTCCTCCGTCCCACCTCCAG
CCGAATAGAAGGTCTGCTCCCGGATCACCCTCAGCCTTGGTGCTCAGTGGTCCCGAGGCCCTAGACCCCCACCCCCCGCCAGTTGCTTTG
TCTGGTAGCTCAAGAGAAGGCAGAGCCCCAGCACCTCTGTGCCCCCCAGAGCTCTGTGCAGGGAGTTGGCCAGCTGCCGCATCATCGGCC
ACCAAGGGCACAAGAGGCGGAGGCTCCAGTCCCTGCTGGGCTGCCTCAGTCTTCAGTGCTGATTGTGTCACGGGTCAGCGTGCGCTGCTG
AGCCCTGTACTGTTAACAGTGCAAAGCTAGTGAGTAGCTGTCAGGTTCCCTGGGCCTGCCATCAGGGATCACTAAATTTAAGGCTTCCAG
ATCCCTGGCAGGAACAGATTCCAGTCCTGCTTACTCAGTACATTTGCTCCAAACTTTTCAACTTGAGGGCAATACTAAACTTAAAAATAA
GAGTTTTTTTATTACAAAATTATTTTTATGGTCCCTTTAACGAGGACCCTATGGCAAATGCACAATTATTCAGAATTACATTTTATCGTT
TTCACATTGAAAACAGCAAATGTTGACTTAGTAATTTTTATATCGATATCTATATGTATATGTATATTTAATCAACCAGCAGTTTTGAAA
CTAGTCATCCTGGTACAAAAGTTTTGCAGCATTGCCTAAATTATAGTGCTCAACACAAGAACTGTTTTTGGGGCCAGTTTAGCATTTGTG
CCGCCTCCTTTTGCTACTCAAAACAGCAATGCTTGGCGGCAGCCTTCCATGAGGCAGAAGGGGTCGTCGTTCTCTGAAAACAGTGACTCT
GAAATGTTGGGACAGGGGAAGGGGTGGGAAACATGAACATGCTCAAATAACTCGAGGCTCACGTGCCAAAGTGTGTGTGTGTGTGTGTGT
GTGTGTGTGTGTGTATGATGTTTTGTTTTTTTAAATGTTTTAAAAGCTTAATAGGTTGGCATCAGTTGTAGCCCACAAACATGGCTAGGG
CTTTGGGGATTTGGCATTTTTCTGGTGGTTTACAAGACTTACTCCGAATACAAGAGGAAAAGCTTTAAAAACAAGATTGCATCATAACCC
CCAGGAGCAAAGCAACCTGGAGGCTGCATATCCATGGGCGGGCAGCATAAGAGAATGTGAAGCCCTTCAGTGAGACGAGACGAGCAATGG
GAAACCTTTTCTGTTCTTAAGAAGTGACTTTAATTTTATTGACATATGTACTGTATGTTACTGAGATTGAATGTTAGGGGAAGCCTTAAG
GTAGAGGTATTTGGGAAAGTAGCCAGTGGGCACTTGTGATATCTAAAATCTGTTATCCCAGGACTGTGTACAGAGGGGCAACCTACCCAT
TCAGGAAGGTCAGGGCTTTGGAACCCTAAAAAGTTGGCCCGATGACTTAAAGGGAAAAATAATTCATTCCCAGAGATGAGTCAGAACAGT
CTCCTCAATCCTGAAATTCAACAAGGCATCAGAAGGGCTGGCTGTGGTCAAGCCCAGCTGCTGTCATGTGAGGAGATGCTCACTGTGGTC
TTGTTGAGCTGATGGCCTTGGTTGAGCTGATGGACAAGTGAAGGAGGCCATGGGGCTGTGCTGTCCTTCCTGCCGTACGTGCCATTCCAC
TCTCTTCAGCTCTCCCCTCAACAGCATGCGAGCCCATACCTTCTGCATTTTTCCAGGCCTGTGAGGGATATAGGCCTCCCCTTGGAGCAC
TGAGTCCGGAGGTCATCCCTGAGCTCATCCACGGCTCATGCTGTGGCTCCGAGTAGTGGTTTGAGTGGGCAGGAAGGGCCATTTGCAAAC
ACTGCTGTGTTCTAGACAAACAACCCAAGTCCTATGGCAGGATTTCTTCCTTCCTTCCTTTTTTACCCAGGTGATGAAGTGCACCCATTG
TACTGGGAAGAATGAAGAGGTGATACCTTTACTAGATCCTTCAGACACATCTATGAGAAGATTTGTTCATTTAAAAGTCTGCCCACTGAG
GATAGGGAAAGGATTAAGGATTTTTCCACCTCCTCTTAGTAACTCCTGAATTACCAACATCAACTTCTTTCTCTCCGTTCCTGAAGGAAC
TTTGGGGAATCATCTTCATCCGTAGTTACGCTTTCCTGAACCTTCTCAGTGGTTTACATGCCTCTGAAACTATGTGCAATATTTTTGGTT
GACACTTGTATCCATCCTTAAGAAATTAGTGCAGATTGCAGATGTTCTGTCTTCCATCCCAAACAAGCCTGCCATGAGGTAGGATCCTAG
GGGTTTGGCTGTTCTTACTCCACTGCTCAGAAAGCTTCCATTCTGCTGTCCTCAGCCTCGACCCTCTTCTGTGCTGGACTTCCACCCACC
CACCCTTTTCAAGTTTAGATAGTGTTTCAGCTGCTGTCCCAAAGTAACAAAACAATACCTACTGTTAAGTAGGAAGTCAATCTGTGTGCT
GGTTTTGTTGGTTATGTGGAAATCACAAACTCCAGAGGAGCAAAGGGGTTTTTCAATGTCTTTTGCTTTCAGAAACAGAGAATATAATAT
TCTCACTAAGGCCTTGAATTGATTTTTTTCTCATAAAATAGTCTGATAAGCTAATTTTTAAAAAGAAATGCCATTAACTGTGTTGTATCG
TGGTTTAAAATTACTAACAAGTTGTGGGAAAGAAAAATAATATTTGATTTTGAATCTTAAATGTTTTTAAAAATTAGACTTGAATGGGCA
CAAAGTATAAATATTTTGTTTCTTTATGGAGGACATGTGGAAGGAGTTTGAGGGTTTGGGATGGGAGAAGTATTTTGCAGAGCTATCAAT

>In-frame_ENST00000225737_ENST00000268719_TCGA-YL-A9WY-01A_AKAP10_chr17_19839599_-_GID4_chr17_17962182_length(amino acids)=587AA_start in transcript=158_stop in transcript=1921
MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKNHALLEAAGPSHVAINAISANMDSFSSSRTAT
LKKQPSHMEAAHFGDLGRSCLDYQTQETKSSLSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQS
SLAEPVSPSKKHETTASFLTDSLDKRLEDSGSAQLFMTHSEGIDLNNRTNSTQNHLLLSQECDSAHSLRLEMARAGTHQVSMETQESSST
LTVASRNSPASPLKELSGKLMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFL
RSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHP
LGFDDVVRLEIESNICREGGPLPNCFTTPLRQAWTTMEKGKFLAFYQYAKSFNSDDFDYEELKNGDYVFMRWKEQFLVPDHTIKDISGAS

--------------------------------------------------------------
>In-frame_ENST00000395536_ENST00000268719_TCGA-YL-A9WY-01A_AKAP10_chr17_19839599_-_GID4_chr17_17962182_length(transcript)=4925nt_BP=1467nt
ATGAGGGGAGCCGGGCCCTCCCCGCGCCAGTCCCCCCGCACCCTCCGTCCCGACCCGGGCCCCGCCATGTCCTTCTTCCGGCGGAAAGTG
AAAGGCAAAGAACAAGAGAAGACCTCAGATGTGAAGTCCATTAAAGCTTCAATATCCGTACATTCCCCACAAAAAAGCACTAAAAATCAT
GCCTTGCTGGAGGCTGCAGGACCAAGTCATGTTGCAATCAATGCCATTTCTGCCAACATGGACTCCTTTTCAAGTAGCAGGACAGCCACA
CTTAAGAAGCAGCCAAGCCACATGGAGGCCGCTCATTTTGGTGACCTGGGCAGATCTTGTCTGGACTACCAGACTCAAGAGACCAAATCA
AGCCTTTCTAAGACCCTTGAACAAGTCTTGCACGACACTATTGTCCTCCCTTACTTCATTCAATTCATGGAACTTCGGCGAATGGAGCAT
TTGGTGAAATTTTGGTTAGAGGCTGAAAGTTTTCATTCAACAACTTGGTCGCGAATAAGAGCACACAGTCTAAACACAGTGAAGCAGAGC
TCACTGGCTGAGCCTGTCTCTCCATCTAAAAAGCATGAAACTACAGCGTCTTTTTTAACTGATTCTCTTGATAAGAGATTGGAGGATTCT
GGCTCAGCACAGTTGTTTATGACTCATTCAGAAGGAATTGACCTGAATAATAGAACTAACAGCACTCAGAATCACTTGCTGCTTTCCCAG
GAATGTGACAGTGCCCATTCTCTCCGTCTTGAAATGGCCAGAGCAGGAACTCACCAAGTTTCCATGGAAACCCAAGAATCTTCCTCTACA
CTTACAGTAGCCAGTAGAAATAGTCCCGCTTCTCCACTAAAAGAATTGTCAGGAAAACTAATGAAAAGTATAGAACAAGATGCAGTGAAT
ACTTTTACCAAATATATATCTCCAGATGCTGCTAAACCAATACCAATTACAGAAGCAATGAGAAATGACATCATAGCAAGGATTTGTGGA
GAAGATGGACAGGTGGATCCCAACTGTTTCGTTTTGGCACAGTCCATAGTCTTTAGTGCAATGGAGCAAGAGCACTTTAGTGAGTTTCTG
CGAAGTCACCATTTCTGTAAATACCAGATTGAAGTGCTGACCAGTGGAACTGTTTACCTGGCTGACATTCTCTTCTGTGAGTCAGCCCTC
TTTTATTTCTCTGAGTACATGGAAAAAGAGGATGCAGTGAATATCTTACAATTCTGGTTGGCAGCAGATAACTTCCAGTCTCAGCTTGCT
GCCAAAAAGGGCCAATATGATGGACAGGAGGCACAGAATGATGCCATGATTTTATATGACAAGTACTTCTCCCTCCAAGCCACACATCCT
CTTGGATTTGATGATGTTGTACGATTAGAAATTGAATCCAATATCTGCAGGGAAGGTGGGCCACTCCCCAACTGTTTCACAACTCCATTA
CGTCAGGCCTGGACAACCATGGAGAAGGGCAAGTTTCTGGCTTTTTATCAGTATGCAAAATCATTTAACTCAGATGACTTTGATTATGAA
GAGCTGAAGAATGGAGACTACGTCTTCATGAGGTGGAAGGAACAGTTTCTGGTCCCAGATCACACGATCAAAGACATCAGTGGTGCTTCT
TTTGCCGGGTTCTACTACATCTGCTTTCAGAAGTCAGCAGCCTCCATAGAGGGCTACTACTACCATAGGAGTTCAGAATGGTATCAGTCC
CTCAATCTAACCCATGTTCCTGAACACAGTGCACCCATCTATGAATTCCGGTGACAACGGTTCAGAACAGCAACCAAATAAAACTGAACT
TGGCAAAAAAGAACTTTGCCGAGAAAATTGTGTACCTGCCAGAACCAGGAGAAGTGTGTTCCTGTTTCTTCACGAGCAGACTCGCATCAC
AAAGCATGAATGTTAACCCACAGAATCCAAGGAGCATGGCTGGCCCGTGGGGCAGGTGGAGGGAGCAGTCTTCGTTCTTCCTCCCCTCAG
TGGCAGTTTGGTCTTCACCTGTTTTTAAGCTACCTTAAACGCACTTTTCCTTCCTGCACAGCTAACTTCTACATCACTGAAATGCCCATT
CCTTCCTCCGTCCCACCTCCAGCCGAATAGAAGGTCTGCTCCCGGATCACCCTCAGCCTTGGTGCTCAGTGGTCCCGAGGCCCTAGACCC
CCACCCCCCGCCAGTTGCTTTGTCTGGTAGCTCAAGAGAAGGCAGAGCCCCAGCACCTCTGTGCCCCCCAGAGCTCTGTGCAGGGAGTTG
GCCAGCTGCCGCATCATCGGCCACCAAGGGCACAAGAGGCGGAGGCTCCAGTCCCTGCTGGGCTGCCTCAGTCTTCAGTGCTGATTGTGT
CACGGGTCAGCGTGCGCTGCTGAGCCCTGTACTGTTAACAGTGCAAAGCTAGTGAGTAGCTGTCAGGTTCCCTGGGCCTGCCATCAGGGA
TCACTAAATTTAAGGCTTCCAGATCCCTGGCAGGAACAGATTCCAGTCCTGCTTACTCAGTACATTTGCTCCAAACTTTTCAACTTGAGG
GCAATACTAAACTTAAAAATAAGAGTTTTTTTATTACAAAATTATTTTTATGGTCCCTTTAACGAGGACCCTATGGCAAATGCACAATTA
TTCAGAATTACATTTTATCGTTTTCACATTGAAAACAGCAAATGTTGACTTAGTAATTTTTATATCGATATCTATATGTATATGTATATT
TAATCAACCAGCAGTTTTGAAACTAGTCATCCTGGTACAAAAGTTTTGCAGCATTGCCTAAATTATAGTGCTCAACACAAGAACTGTTTT
TGGGGCCAGTTTAGCATTTGTGCCGCCTCCTTTTGCTACTCAAAACAGCAATGCTTGGCGGCAGCCTTCCATGAGGCAGAAGGGGTCGTC
GTTCTCTGAAAACAGTGACTCTGAAATGTTGGGACAGGGGAAGGGGTGGGAAACATGAACATGCTCAAATAACTCGAGGCTCACGTGCCA
AAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGATGTTTTGTTTTTTTAAATGTTTTAAAAGCTTAATAGGTTGGCATCAGTTG
TAGCCCACAAACATGGCTAGGGCTTTGGGGATTTGGCATTTTTCTGGTGGTTTACAAGACTTACTCCGAATACAAGAGGAAAAGCTTTAA
AAACAAGATTGCATCATAACCCCCAGGAGCAAAGCAACCTGGAGGCTGCATATCCATGGGCGGGCAGCATAAGAGAATGTGAAGCCCTTC
AGTGAGACGAGACGAGCAATGGGAAACCTTTTCTGTTCTTAAGAAGTGACTTTAATTTTATTGACATATGTACTGTATGTTACTGAGATT
GAATGTTAGGGGAAGCCTTAAGGTAGAGGTATTTGGGAAAGTAGCCAGTGGGCACTTGTGATATCTAAAATCTGTTATCCCAGGACTGTG
TACAGAGGGGCAACCTACCCATTCAGGAAGGTCAGGGCTTTGGAACCCTAAAAAGTTGGCCCGATGACTTAAAGGGAAAAATAATTCATT
CCCAGAGATGAGTCAGAACAGTCTCCTCAATCCTGAAATTCAACAAGGCATCAGAAGGGCTGGCTGTGGTCAAGCCCAGCTGCTGTCATG
TGAGGAGATGCTCACTGTGGTCTTGTTGAGCTGATGGCCTTGGTTGAGCTGATGGACAAGTGAAGGAGGCCATGGGGCTGTGCTGTCCTT
CCTGCCGTACGTGCCATTCCACTCTCTTCAGCTCTCCCCTCAACAGCATGCGAGCCCATACCTTCTGCATTTTTCCAGGCCTGTGAGGGA
TATAGGCCTCCCCTTGGAGCACTGAGTCCGGAGGTCATCCCTGAGCTCATCCACGGCTCATGCTGTGGCTCCGAGTAGTGGTTTGAGTGG
GCAGGAAGGGCCATTTGCAAACACTGCTGTGTTCTAGACAAACAACCCAAGTCCTATGGCAGGATTTCTTCCTTCCTTCCTTTTTTACCC
AGGTGATGAAGTGCACCCATTGTACTGGGAAGAATGAAGAGGTGATACCTTTACTAGATCCTTCAGACACATCTATGAGAAGATTTGTTC
ATTTAAAAGTCTGCCCACTGAGGATAGGGAAAGGATTAAGGATTTTTCCACCTCCTCTTAGTAACTCCTGAATTACCAACATCAACTTCT
TTCTCTCCGTTCCTGAAGGAACTTTGGGGAATCATCTTCATCCGTAGTTACGCTTTCCTGAACCTTCTCAGTGGTTTACATGCCTCTGAA
ACTATGTGCAATATTTTTGGTTGACACTTGTATCCATCCTTAAGAAATTAGTGCAGATTGCAGATGTTCTGTCTTCCATCCCAAACAAGC
CTGCCATGAGGTAGGATCCTAGGGGTTTGGCTGTTCTTACTCCACTGCTCAGAAAGCTTCCATTCTGCTGTCCTCAGCCTCGACCCTCTT
CTGTGCTGGACTTCCACCCACCCACCCTTTTCAAGTTTAGATAGTGTTTCAGCTGCTGTCCCAAAGTAACAAAACAATACCTACTGTTAA
GTAGGAAGTCAATCTGTGTGCTGGTTTTGTTGGTTATGTGGAAATCACAAACTCCAGAGGAGCAAAGGGGTTTTTCAATGTCTTTTGCTT
TCAGAAACAGAGAATATAATATTCTCACTAAGGCCTTGAATTGATTTTTTTCTCATAAAATAGTCTGATAAGCTAATTTTTAAAAAGAAA
TGCCATTAACTGTGTTGTATCGTGGTTTAAAATTACTAACAAGTTGTGGGAAAGAAAAATAATATTTGATTTTGAATCTTAAATGTTTTT
AAAAATTAGACTTGAATGGGCACAAAGTATAAATATTTTGTTTCTTTATGGAGGACATGTGGAAGGAGTTTGAGGGTTTGGGATGGGAGA

>In-frame_ENST00000395536_ENST00000268719_TCGA-YL-A9WY-01A_AKAP10_chr17_19839599_-_GID4_chr17_17962182_length(amino acids)=587AA_start in transcript=0_stop in transcript=1763
MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKNHALLEAAGPSHVAINAISANMDSFSSSRTAT
LKKQPSHMEAAHFGDLGRSCLDYQTQETKSSLSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQS
SLAEPVSPSKKHETTASFLTDSLDKRLEDSGSAQLFMTHSEGIDLNNRTNSTQNHLLLSQECDSAHSLRLEMARAGTHQVSMETQESSST
LTVASRNSPASPLKELSGKLMKSIEQDAVNTFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFL
RSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHP
LGFDDVVRLEIESNICREGGPLPNCFTTPLRQAWTTMEKGKFLAFYQYAKSFNSDDFDYEELKNGDYVFMRWKEQFLVPDHTIKDISGAS

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Fusion Gene PPI Analysis for AKAP10-GID4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKAP10-GID4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKAP10-GID4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKAP10C0005586Bipolar Disorder1PSYGENET