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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GOSR1-CPD (FusionGDB2 ID:33908)

Fusion Gene Summary for GOSR1-CPD

check button Fusion gene summary
Fusion gene informationFusion gene name: GOSR1-CPD
Fusion gene ID: 33908
HgeneTgene
Gene symbol

GOSR1

CPD

Gene ID

9527

9455

Gene namegolgi SNAP receptor complex member 1homer scaffold protein 2
SynonymsGOLIM2|GOS-28|GOS28|GOS28/P28|GS28|P28ACPD|CPD|DFNA68|HOMER-2|VESL-2
Cytomap

17q11.2

15q25.2

Type of geneprotein-codingprotein-coding
DescriptionGolgi SNAP receptor complex member 128 kDa Golgi SNARE protein28 kDa cis-Golgi SNARE p28Golgi SNARE 28 kDacis-golgi SNAREgolgi integral membrane protein 2homer protein homolog 2cupidinhomer homolog 2homer homolog 3homer scaffolding protein 2homer, neuronal immediate early gene, 2
Modification date2020031320200313
UniProtAcc

O95249

O75976

Ensembl transtripts involved in fusion geneENST00000225724, ENST00000451249, 
ENST00000467337, ENST00000581721, 
ENST00000579905, 		ENST00000225719, 
ENST00000543464, ENST00000584051, 
Fusion gene scores* DoF score9 X 5 X 8=36011 X 13 X 7=1001
# samples 1013
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1001*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GOSR1 [Title/Abstract] AND CPD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGOSR1(28811788)-CPD(28788198), # samples:3
GOSR1(28811788)-CPD(28788895), # samples:3
CPD(28756582)-GOSR1(28819770), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGOSR1

GO:0042147

retrograde transport, endosome to Golgi

15215310


check buttonFusion gene breakpoints across GOSR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CPD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-2H-A9GJ-01AGOSR1chr17

28811788

+CPDchr17

28788198

+
ChimerDB4LIHCTCGA-BC-A8YO-01AGOSR1chr17

28811788

+CPDchr17

28788895

+
ChimerDB4ESCATCGA-2H-A9GJGOSR1chr17

28811788

+CPDchr17

28788198

+
ChimerDB4LIHCTCGA-BC-A8YO-01AGOSR1chr17

28811788

+CPDchr17

28788895

+
ChimerDB4ESCATCGA-2H-A9GJ-01AGOSR1chr17

28811788

-CPDchr17

28788198

+
ChimerDB4LIHCTCGA-BC-A8YO-01AGOSR1chr17

28811788

-CPDchr17

28788895

+


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Fusion Gene ORF analysis for GOSR1-CPD

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000225724ENST00000225719GOSR1chr17

28811788

+CPDchr17

28788198

+
In-frameENST00000225724ENST00000543464GOSR1chr17

28811788

+CPDchr17

28788198

+
5CDS-3UTRENST00000225724ENST00000584051GOSR1chr17

28811788

+CPDchr17

28788198

+
In-frameENST00000451249ENST00000225719GOSR1chr17

28811788

+CPDchr17

28788198

+
In-frameENST00000451249ENST00000543464GOSR1chr17

28811788

+CPDchr17

28788198

+
5CDS-3UTRENST00000451249ENST00000584051GOSR1chr17

28811788

+CPDchr17

28788198

+
In-frameENST00000467337ENST00000225719GOSR1chr17

28811788

+CPDchr17

28788198

+
In-frameENST00000467337ENST00000543464GOSR1chr17

28811788

+CPDchr17

28788198

+
5CDS-3UTRENST00000467337ENST00000584051GOSR1chr17

28811788

+CPDchr17

28788198

+
In-frameENST00000581721ENST00000225719GOSR1chr17

28811788

+CPDchr17

28788198

+
In-frameENST00000581721ENST00000543464GOSR1chr17

28811788

+CPDchr17

28788198

+
5CDS-3UTRENST00000581721ENST00000584051GOSR1chr17

28811788

+CPDchr17

28788198

+
intron-3CDSENST00000579905ENST00000225719GOSR1chr17

28811788

+CPDchr17

28788198

+
intron-3CDSENST00000579905ENST00000543464GOSR1chr17

28811788

+CPDchr17

28788198

+
intron-3UTRENST00000579905ENST00000584051GOSR1chr17

28811788

+CPDchr17

28788198

+
In-frameENST00000225724ENST00000225719GOSR1chr17

28811788

+CPDchr17

28788895

+
In-frameENST00000225724ENST00000543464GOSR1chr17

28811788

+CPDchr17

28788895

+
5CDS-intronENST00000225724ENST00000584051GOSR1chr17

28811788

+CPDchr17

28788895

+
In-frameENST00000451249ENST00000225719GOSR1chr17

28811788

+CPDchr17

28788895

+
In-frameENST00000451249ENST00000543464GOSR1chr17

28811788

+CPDchr17

28788895

+
5CDS-intronENST00000451249ENST00000584051GOSR1chr17

28811788

+CPDchr17

28788895

+
In-frameENST00000467337ENST00000225719GOSR1chr17

28811788

+CPDchr17

28788895

+
In-frameENST00000467337ENST00000543464GOSR1chr17

28811788

+CPDchr17

28788895

+
5CDS-intronENST00000467337ENST00000584051GOSR1chr17

28811788

+CPDchr17

28788895

+
In-frameENST00000581721ENST00000225719GOSR1chr17

28811788

+CPDchr17

28788895

+
In-frameENST00000581721ENST00000543464GOSR1chr17

28811788

+CPDchr17

28788895

+
5CDS-intronENST00000581721ENST00000584051GOSR1chr17

28811788

+CPDchr17

28788895

+
intron-3CDSENST00000579905ENST00000225719GOSR1chr17

28811788

+CPDchr17

28788895

+
intron-3CDSENST00000579905ENST00000543464GOSR1chr17

28811788

+CPDchr17

28788895

+
intron-intronENST00000579905ENST00000584051GOSR1chr17

28811788

+CPDchr17

28788895

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GOSR1-CPD


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GOSR1chr1728811788+CPDchr1728788894+0.0002495890.99975044
GOSR1chr1728811788+CPDchr1728788197+0.000107530.9998925
GOSR1chr1728811788+CPDchr1728788197+0.000107530.9998925
GOSR1chr1728811788+CPDchr1728788894+0.0002495890.99975044
GOSR1chr1728811788+CPDchr1728788197+0.000107530.9998925
GOSR1chr1728811788+CPDchr1728788197+0.000107530.9998925

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GOSR1-CPD


check button Go to

FGviewer for the breakpoints of chr17:28811788-chr17:28788198

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GOSR1

O95249

CPD

O75976

FUNCTION: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:21860593}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGOSR1chr17:28811788chr17:28788198ENST00000225724+4968_95116.0251.0Coiled coilOntology_term=ECO:0000255
HgeneGOSR1chr17:28811788chr17:28788198ENST00000225724+499_30116.0251.0Coiled coilOntology_term=ECO:0000255
HgeneGOSR1chr17:28811788chr17:28788198ENST00000467337+499_3051.0186.0Coiled coilOntology_term=ECO:0000255
HgeneGOSR1chr17:28811788chr17:28788895ENST00000225724+4968_95116.0251.0Coiled coilOntology_term=ECO:0000255
HgeneGOSR1chr17:28811788chr17:28788895ENST00000225724+499_30116.0251.0Coiled coilOntology_term=ECO:0000255
HgeneGOSR1chr17:28811788chr17:28788895ENST00000467337+499_3051.0186.0Coiled coilOntology_term=ECO:0000255
TgeneCPDchr17:28811788chr17:28788198ENST0000022571916211321_13801166.01381.0Topological domainCytoplasmic
TgeneCPDchr17:28811788chr17:28788198ENST0000054346416211321_1380919.01134.0Topological domainCytoplasmic
TgeneCPDchr17:28811788chr17:28788895ENST0000022571917211321_13801210.01381.0Topological domainCytoplasmic
TgeneCPDchr17:28811788chr17:28788895ENST0000054346417211321_1380963.01134.0Topological domainCytoplasmic
TgeneCPDchr17:28811788chr17:28788198ENST0000022571916211300_13201166.01381.0TransmembraneHelical
TgeneCPDchr17:28811788chr17:28788198ENST0000054346416211300_1320919.01134.0TransmembraneHelical
TgeneCPDchr17:28811788chr17:28788895ENST0000022571917211300_13201210.01381.0TransmembraneHelical
TgeneCPDchr17:28811788chr17:28788895ENST0000054346417211300_1320963.01134.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGOSR1chr17:28811788chr17:28788198ENST00000467337+4968_9551.0186.0Coiled coilOntology_term=ECO:0000255
HgeneGOSR1chr17:28811788chr17:28788895ENST00000467337+4968_9551.0186.0Coiled coilOntology_term=ECO:0000255
HgeneGOSR1chr17:28811788chr17:28788198ENST00000225724+492_229116.0251.0Topological domainCytoplasmic
HgeneGOSR1chr17:28811788chr17:28788198ENST00000467337+492_22951.0186.0Topological domainCytoplasmic
HgeneGOSR1chr17:28811788chr17:28788895ENST00000225724+492_229116.0251.0Topological domainCytoplasmic
HgeneGOSR1chr17:28811788chr17:28788895ENST00000467337+492_22951.0186.0Topological domainCytoplasmic
HgeneGOSR1chr17:28811788chr17:28788198ENST00000225724+49230_250116.0251.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneGOSR1chr17:28811788chr17:28788198ENST00000467337+49230_25051.0186.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneGOSR1chr17:28811788chr17:28788895ENST00000225724+49230_250116.0251.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneGOSR1chr17:28811788chr17:28788895ENST00000467337+49230_25051.0186.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneCPDchr17:28811788chr17:28788198ENST000002257191621162_1641166.01381.0MotifCell attachment site
TgeneCPDchr17:28811788chr17:28788198ENST000005434641621162_164919.01134.0MotifCell attachment site
TgeneCPDchr17:28811788chr17:28788895ENST000002257191721162_1641210.01381.0MotifCell attachment site
TgeneCPDchr17:28811788chr17:28788895ENST000005434641721162_164963.01134.0MotifCell attachment site
TgeneCPDchr17:28811788chr17:28788198ENST00000225719162132_4931166.01381.0RegionNote=Carboxypeptidase-like 1
TgeneCPDchr17:28811788chr17:28788198ENST000002257191621494_8971166.01381.0RegionNote=Carboxypeptidase-like 2
TgeneCPDchr17:28811788chr17:28788198ENST000002257191621898_12991166.01381.0RegionNote=Carboxypeptidase-like 3
TgeneCPDchr17:28811788chr17:28788198ENST00000543464162132_493919.01134.0RegionNote=Carboxypeptidase-like 1
TgeneCPDchr17:28811788chr17:28788198ENST000005434641621494_897919.01134.0RegionNote=Carboxypeptidase-like 2
TgeneCPDchr17:28811788chr17:28788198ENST000005434641621898_1299919.01134.0RegionNote=Carboxypeptidase-like 3
TgeneCPDchr17:28811788chr17:28788895ENST00000225719172132_4931210.01381.0RegionNote=Carboxypeptidase-like 1
TgeneCPDchr17:28811788chr17:28788895ENST000002257191721494_8971210.01381.0RegionNote=Carboxypeptidase-like 2
TgeneCPDchr17:28811788chr17:28788895ENST000002257191721898_12991210.01381.0RegionNote=Carboxypeptidase-like 3
TgeneCPDchr17:28811788chr17:28788895ENST00000543464172132_493963.01134.0RegionNote=Carboxypeptidase-like 1
TgeneCPDchr17:28811788chr17:28788895ENST000005434641721494_897963.01134.0RegionNote=Carboxypeptidase-like 2
TgeneCPDchr17:28811788chr17:28788895ENST000005434641721898_1299963.01134.0RegionNote=Carboxypeptidase-like 3
TgeneCPDchr17:28811788chr17:28788198ENST00000225719162132_12991166.01381.0Topological domainExtracellular
TgeneCPDchr17:28811788chr17:28788198ENST00000543464162132_1299919.01134.0Topological domainExtracellular
TgeneCPDchr17:28811788chr17:28788895ENST00000225719172132_12991210.01381.0Topological domainExtracellular
TgeneCPDchr17:28811788chr17:28788895ENST00000543464172132_1299963.01134.0Topological domainExtracellular


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Fusion Gene Sequence for GOSR1-CPD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GOSR1-CPD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GOSR1-CPD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GOSR1-CPD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource