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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKAP12-ASCC3 (FusionGDB2 ID:3398)

Fusion Gene Summary for AKAP12-ASCC3

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP12-ASCC3
Fusion gene ID: 3398
HgeneTgene
Gene symbol

AKAP12

ASCC3

Gene ID

9590

10973

Gene nameA-kinase anchoring protein 12activating signal cointegrator 1 complex subunit 3
SynonymsAKAP250|SSeCKSASC1p200|HELIC1|RNAH
Cytomap

6q25.1

6q16.3

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 12A kinase (PRKA) anchor protein 12A-kinase anchor protein, 250kDaAKAP 250Src-Suppressed C Kinase Substratekinase scaffold protein gravinmyasthenia gravis autoantigen gravinactivating signal cointegrator 1 complex subunit 3ASC-1 complex subunit P200RNA helicase familyhelicase, ATP binding 1trip4 complex subunit p200
Modification date2020032720200313
UniProtAcc

Q02952

Q8N3C0

Ensembl transtripts involved in fusion geneENST00000402676, ENST00000253332, 
ENST00000354675, ENST00000359755, 
ENST00000490177, 		ENST00000369162, 
ENST00000522650, ENST00000369143, 
Fusion gene scores* DoF score6 X 5 X 2=6014 X 10 X 11=1540
# samples 718
** MAII scorelog2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(18/1540*10)=-3.09686153925259
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKAP12 [Title/Abstract] AND ASCC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKAP12(151561859)-ASCC3(101037935), # samples:3
Anticipated loss of major functional domain due to fusion event.AKAP12-ASCC3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
AKAP12-ASCC3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneASCC3

GO:0006307

DNA dealkylation involved in DNA repair

22055184

TgeneASCC3

GO:0032508

DNA duplex unwinding

22055184


check buttonFusion gene breakpoints across AKAP12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ASCC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-HB-A3YV-01AAKAP12chr6

151561859

+ASCC3chr6

101037935

-
ChimerDB4SARCTCGA-HB-A3YVAKAP12chr6

151561859

+ASCC3chr6

100988263

-
ChimerDB4SARCTCGA-X9-A971-01AAKAP12chr6

151561859

+ASCC3chr6

101037935

-
ChimerDB4SARCTCGA-X9-A971-01AAKAP12chr6

151561859

+ASCC3chr6

100988263

-
ChimerDB4SARCTCGA-HB-A3YV-01AAKAP12chr6

151561859

-ASCC3chr6

101037935

-


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Fusion Gene ORF analysis for AKAP12-ASCC3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000402676ENST00000369162AKAP12chr6

151561859

+ASCC3chr6

101037935

-
5CDS-intronENST00000402676ENST00000522650AKAP12chr6

151561859

+ASCC3chr6

101037935

-
5CDS-intronENST00000402676ENST00000369143AKAP12chr6

151561859

+ASCC3chr6

101037935

-
Frame-shiftENST00000253332ENST00000369162AKAP12chr6

151561859

+ASCC3chr6

101037935

-
5CDS-intronENST00000253332ENST00000522650AKAP12chr6

151561859

+ASCC3chr6

101037935

-
5CDS-intronENST00000253332ENST00000369143AKAP12chr6

151561859

+ASCC3chr6

101037935

-
intron-3CDSENST00000354675ENST00000369162AKAP12chr6

151561859

+ASCC3chr6

101037935

-
intron-intronENST00000354675ENST00000522650AKAP12chr6

151561859

+ASCC3chr6

101037935

-
intron-intronENST00000354675ENST00000369143AKAP12chr6

151561859

+ASCC3chr6

101037935

-
intron-3CDSENST00000359755ENST00000369162AKAP12chr6

151561859

+ASCC3chr6

101037935

-
intron-intronENST00000359755ENST00000522650AKAP12chr6

151561859

+ASCC3chr6

101037935

-
intron-intronENST00000359755ENST00000369143AKAP12chr6

151561859

+ASCC3chr6

101037935

-
intron-3CDSENST00000490177ENST00000369162AKAP12chr6

151561859

+ASCC3chr6

101037935

-
intron-intronENST00000490177ENST00000522650AKAP12chr6

151561859

+ASCC3chr6

101037935

-
intron-intronENST00000490177ENST00000369143AKAP12chr6

151561859

+ASCC3chr6

101037935

-
In-frameENST00000402676ENST00000369162AKAP12chr6

151561859

+ASCC3chr6

100988263

-
5CDS-intronENST00000402676ENST00000522650AKAP12chr6

151561859

+ASCC3chr6

100988263

-
5CDS-intronENST00000402676ENST00000369143AKAP12chr6

151561859

+ASCC3chr6

100988263

-
In-frameENST00000253332ENST00000369162AKAP12chr6

151561859

+ASCC3chr6

100988263

-
5CDS-intronENST00000253332ENST00000522650AKAP12chr6

151561859

+ASCC3chr6

100988263

-
5CDS-intronENST00000253332ENST00000369143AKAP12chr6

151561859

+ASCC3chr6

100988263

-
intron-3CDSENST00000354675ENST00000369162AKAP12chr6

151561859

+ASCC3chr6

100988263

-
intron-intronENST00000354675ENST00000522650AKAP12chr6

151561859

+ASCC3chr6

100988263

-
intron-intronENST00000354675ENST00000369143AKAP12chr6

151561859

+ASCC3chr6

100988263

-
intron-3CDSENST00000359755ENST00000369162AKAP12chr6

151561859

+ASCC3chr6

100988263

-
intron-intronENST00000359755ENST00000522650AKAP12chr6

151561859

+ASCC3chr6

100988263

-
intron-intronENST00000359755ENST00000369143AKAP12chr6

151561859

+ASCC3chr6

100988263

-
intron-3CDSENST00000490177ENST00000369162AKAP12chr6

151561859

+ASCC3chr6

100988263

-
intron-intronENST00000490177ENST00000522650AKAP12chr6

151561859

+ASCC3chr6

100988263

-
intron-intronENST00000490177ENST00000369143AKAP12chr6

151561859

+ASCC3chr6

100988263

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000402676AKAP12chr6151561859+ENST00000369162ASCC3chr6100988263-26534022401460406
ENST00000253332AKAP12chr6151561859+ENST00000369162ASCC3chr6100988263-26023511891409406

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000402676ENST00000369162AKAP12chr6151561859+ASCC3chr6100988263-0.0011289280.998871
ENST00000253332ENST00000369162AKAP12chr6151561859+ASCC3chr6100988263-0.0009362450.9990638

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Fusion Genomic Features for AKAP12-ASCC3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AKAP12-ASCC3


check button Go to

FGviewer for the breakpoints of chr6:151561859-chr6:100988263

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP12

Q02952

ASCC3

Q8N3C0

FUNCTION: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).FUNCTION: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:22055184}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneASCC3chr6:151561859chr6:100988263ENST000003691430418_790112.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr6:151561859chr6:100988263ENST0000036914304328_3560112.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr6:151561859chr6:100988263ENST0000052265001318_790732.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr6:151561859chr6:100988263ENST00000522650013328_3560732.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr6:151561859chr6:100988263ENST00000369143041336_15110112.0DomainHelicase ATP-binding 2
TgeneASCC3chr6:151561859chr6:100988263ENST00000369143041544_17390112.0DomainHelicase C-terminal 2
TgeneASCC3chr6:151561859chr6:100988263ENST00000369143041812_21760112.0DomainNote=SEC63 2
TgeneASCC3chr6:151561859chr6:100988263ENST0000036914304486_6690112.0DomainHelicase ATP-binding 1
TgeneASCC3chr6:151561859chr6:100988263ENST0000036914304728_9140112.0DomainHelicase C-terminal 1
TgeneASCC3chr6:151561859chr6:100988263ENST0000036914304978_12870112.0DomainNote=SEC63 1
TgeneASCC3chr6:151561859chr6:100988263ENST000005226500131336_15110732.0DomainHelicase ATP-binding 2
TgeneASCC3chr6:151561859chr6:100988263ENST000005226500131544_17390732.0DomainHelicase C-terminal 2
TgeneASCC3chr6:151561859chr6:100988263ENST000005226500131812_21760732.0DomainNote=SEC63 2
TgeneASCC3chr6:151561859chr6:100988263ENST00000522650013486_6690732.0DomainHelicase ATP-binding 1
TgeneASCC3chr6:151561859chr6:100988263ENST00000522650013728_9140732.0DomainHelicase C-terminal 1
TgeneASCC3chr6:151561859chr6:100988263ENST00000522650013978_12870732.0DomainNote=SEC63 1
TgeneASCC3chr6:151561859chr6:100988263ENST00000369143041453_14560112.0MotifNote=DEIH box
TgeneASCC3chr6:151561859chr6:100988263ENST0000036914304611_6140112.0MotifNote=DEVH box
TgeneASCC3chr6:151561859chr6:100988263ENST000005226500131453_14560732.0MotifNote=DEIH box
TgeneASCC3chr6:151561859chr6:100988263ENST00000522650013611_6140732.0MotifNote=DEVH box
TgeneASCC3chr6:151561859chr6:100988263ENST00000369143041349_13560112.0Nucleotide bindingATP
TgeneASCC3chr6:151561859chr6:100988263ENST0000036914304499_5060112.0Nucleotide bindingATP
TgeneASCC3chr6:151561859chr6:100988263ENST000005226500131349_13560732.0Nucleotide bindingATP
TgeneASCC3chr6:151561859chr6:100988263ENST00000522650013499_5060732.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKAP12chr6:151561859chr6:100988263ENST00000253332+1498_10154.02015.0Compositional biasNote=Poly-Glu
HgeneAKAP12chr6:151561859chr6:100988263ENST00000354675+1398_10101968.0Compositional biasNote=Poly-Glu
HgeneAKAP12chr6:151561859chr6:100988263ENST00000359755+1398_10101993.3333333333333Compositional biasNote=Poly-Glu
HgeneAKAP12chr6:151561859chr6:100988263ENST00000402676+2598_10154.02706.3333333333335Compositional biasNote=Poly-Glu
HgeneAKAP12chr6:151561859chr6:100988263ENST00000253332+14607_62754.02015.0MotifAKAP CaM-binding 1
HgeneAKAP12chr6:151561859chr6:100988263ENST00000253332+14756_77654.02015.0MotifAKAP CaM-binding 2
HgeneAKAP12chr6:151561859chr6:100988263ENST00000253332+14801_82154.02015.0MotifAKAP CaM-binding 3
HgeneAKAP12chr6:151561859chr6:100988263ENST00000354675+13607_62701968.0MotifAKAP CaM-binding 1
HgeneAKAP12chr6:151561859chr6:100988263ENST00000354675+13756_77601968.0MotifAKAP CaM-binding 2
HgeneAKAP12chr6:151561859chr6:100988263ENST00000354675+13801_82101968.0MotifAKAP CaM-binding 3
HgeneAKAP12chr6:151561859chr6:100988263ENST00000359755+13607_62701993.3333333333333MotifAKAP CaM-binding 1
HgeneAKAP12chr6:151561859chr6:100988263ENST00000359755+13756_77601993.3333333333333MotifAKAP CaM-binding 2
HgeneAKAP12chr6:151561859chr6:100988263ENST00000359755+13801_82101993.3333333333333MotifAKAP CaM-binding 3
HgeneAKAP12chr6:151561859chr6:100988263ENST00000402676+25607_62754.02706.3333333333335MotifAKAP CaM-binding 1
HgeneAKAP12chr6:151561859chr6:100988263ENST00000402676+25756_77654.02706.3333333333335MotifAKAP CaM-binding 2
HgeneAKAP12chr6:151561859chr6:100988263ENST00000402676+25801_82154.02706.3333333333335MotifAKAP CaM-binding 3
HgeneAKAP12chr6:151561859chr6:100988263ENST00000253332+141541_155454.02015.0RegionRII-binding
HgeneAKAP12chr6:151561859chr6:100988263ENST00000253332+14266_55754.02015.0RegionInvolved in PKC-binding
HgeneAKAP12chr6:151561859chr6:100988263ENST00000354675+131541_155401968.0RegionRII-binding
HgeneAKAP12chr6:151561859chr6:100988263ENST00000354675+13266_55701968.0RegionInvolved in PKC-binding
HgeneAKAP12chr6:151561859chr6:100988263ENST00000359755+131541_155401993.3333333333333RegionRII-binding
HgeneAKAP12chr6:151561859chr6:100988263ENST00000359755+13266_55701993.3333333333333RegionInvolved in PKC-binding
HgeneAKAP12chr6:151561859chr6:100988263ENST00000402676+251541_155454.02706.3333333333335RegionRII-binding
HgeneAKAP12chr6:151561859chr6:100988263ENST00000402676+25266_55754.02706.3333333333335RegionInvolved in PKC-binding
TgeneASCC3chr6:151561859chr6:100988263ENST00000369162354218_791850.02203.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr6:151561859chr6:100988263ENST000003691623542328_3561850.02203.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr6:151561859chr6:100988263ENST0000036916235421336_15111850.02203.0DomainHelicase ATP-binding 2
TgeneASCC3chr6:151561859chr6:100988263ENST0000036916235421544_17391850.02203.0DomainHelicase C-terminal 2
TgeneASCC3chr6:151561859chr6:100988263ENST0000036916235421812_21761850.02203.0DomainNote=SEC63 2
TgeneASCC3chr6:151561859chr6:100988263ENST000003691623542486_6691850.02203.0DomainHelicase ATP-binding 1
TgeneASCC3chr6:151561859chr6:100988263ENST000003691623542728_9141850.02203.0DomainHelicase C-terminal 1
TgeneASCC3chr6:151561859chr6:100988263ENST000003691623542978_12871850.02203.0DomainNote=SEC63 1
TgeneASCC3chr6:151561859chr6:100988263ENST0000036916235421453_14561850.02203.0MotifNote=DEIH box
TgeneASCC3chr6:151561859chr6:100988263ENST000003691623542611_6141850.02203.0MotifNote=DEVH box
TgeneASCC3chr6:151561859chr6:100988263ENST0000036916235421349_13561850.02203.0Nucleotide bindingATP
TgeneASCC3chr6:151561859chr6:100988263ENST000003691623542499_5061850.02203.0Nucleotide bindingATP


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Fusion Gene Sequence for AKAP12-ASCC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000402676_ENST00000369162_TCGA-HB-A3YV_AKAP12_chr6_151561859_+_ASCC3_chr6_100988263_length(transcript)=2653nt_BP=402nt
GGGACTCGGACTCGCTCCTGGGCGAGCTGAAAGTCGGCTGCAGCAGAAGCTCCTGCCTTGGGAGTTTGCCGCGAGCGCGTCTCCTTCATT
CGCAGGCTGGGCGCGTTCGCAGTCGGCTGGCGGCGAAGGAAGGCGCTCTCGGGACCTCGCGGGCGCGCGTCTTTTGGCTCTTGCCCCTGT
CCCTGCGGCTTGGGGAAGGCGTAACCCGGCGGCTAGGCGCGGGAGAAGTGCGGAGGAGCCATGGGCGCCGGGAGCTCCACCGAGCAGCGC
AGCCCGGAGCAGCCGCCCGAGGGGAGCTCCACGCCGGCTGAGCCCGAGCCCAGCGGCGGCGGCCCCTCGGCCGAGGCGGCGCCAGACACC
ACCGCGGACCCCGCCATCGCTGCCTCGGACCCCGCCACCAAGGATGCAGAAGAATATACAGATTTGCCAGTGAGACACAATGAAGATCAT
ATGAATAGTGAACTGGCAAAATGTCTTCCCATTGAATCAAATCCTCATTCATTTGACAGCCCTCACACCAAAGCACATCTCCTGCTACAG
GCACATCTCAGCCGAGCCATGCTACCCTGCCCAGATTATGACACTGATACCAAAACAGTCTTGGACCAAGCTCTCAGAGTATGTCAGGCA
ATGCTGGACGTGGCTGCAAACCAGGGCTGGCTGGTGACTGTCCTGAATATCACCAACCTGATTCAGATGGTGATCCAGGGTCGGTGGTTA
AAGGACTCTTCTCTTCTTACACTACCAAACATAGAAAACCATCATCTTCACCTTTTCAAGAAATGGAAGCCGATTATGAAGGGCCCACAT
GCTAGGGGTCGGACCTCCATCGAGTCCCTTCCTGAACTGATCCATGCCTGTGGAGGGAAAGACCATGTATTTAGCTCCATGGTAGAAAGT
GAGCTACATGCTGCAAAAACGAAACAGGCATGGAATTTCTTATCTCACTTGCCAGTGATAAATGTTGGCATAAGTGTTAAAGGCTCGTGG
GATGACTTAGTTGAAGGACATAATGAACTCTCTGTCTCAACTCTGACTGCAGACAAACGAGATGACAACAAATGGATCAAATTGCATGCT
GACCAAGAGTATGTGCTTCAAGTGAGCTTGCAGAGAGTCCACTTTGGGTTCCACAAGGGAAAGCCAGAGAGCTGTGCAGTTACTCCTCGA
TTTCCCAAATCAAAAGACGAAGGATGGTTTTTGATATTAGGAGAAGTGGATAAGAGAGAACTTATTGCTTTGAAAAGAGTAGGATATATT
CGAAATCATCATGTTGCTTCCCTTTCTTTTTATACCCCTGAAATACCTGGAAGGTATATCTACACATTATATTTCATGAGTGACTGCTAC
CTTGGCCTGGACCAGCAGTATGACATCTATCTCAACGTTACACAAGCGAGTCTTTCTGCACAGGTCAACACCAAGGTCTCTGATTCCCTG
ACTGACCTGGCATTAAAGTAACTTGACCTGAACAATCCATTTGAAAGGAGTGGCTAAGAATTCTCTCTGTTCAGTCATCTAGACAAATCG
AATTACTTGATGTTTGCCTTGAAAGAATCAACTTCTAACCTCAACCATCCAGGAAATTGACAGTGGCTGCAGTATTGACTCCAGTGACAT
AAAGTTAACCACAGTGGCCTTTTAACAAATGTTGCCTTTTATAATGTTATCTTTATGAGTTTCTTGATATGTAAGATGAAAAAGCATTTA
GAATAATCTTTTAATTTGTGTATATTTGGGATGATATTTAGGAGCTATCAATCAAATTTTACATCTCACAATGTACTGTTTACATGGATA
TTGGCTGCTTTTTTTAAGGAAAACCACATTGAGATGTGACAAGTGTTAGGACTTGTCACAGATTTCTAACTCTGCCGCATAAACTATAAA
TCTGTAAGGTGGTACACAGCGTGTCTTGTTAGCAAAATTTATACTTTGATATGATCACATGTAGAAGTAGCTTCAAGAATTTCTTGTAGT
CATAAATGTTTAATAATATATGATGTAAAATTATATTATGGAGCCTAATGATGATAACAAAGAAAACAATATACTGATCTTAGAAAATGT
AGACATGGTTAACTGGGAAATAAAATATAGAGTGGCACTTCAAGACAAGCTGACTCAATGTTTTCTTCTGCTTCCTTTAAATAATATCCC
CTTACTCATCTGTTCTTCTTTTCTTTCCCTTCTACTTCAAGGCTTTATTTCTATTATCTTTCTGACATATTTATTTACAGAAGTAGAGAA
GTATAATCTAATTCATGTTGTAGCACTTACAGATCATATAGTACAATTATTTGTCTTTATGCTCTCCAGGAAAAATCTGAGACAGAAAAT
TTTTCACCCCTATGGATAGGTTTTCACCTGTAATAAAGAAAATTTCTCTATGTCCAAACAAATTCCTTCTTGAAAAATACTTTTTCAAAC
TAAAAACTTGTTAAAATTCAATGTTCATATAATATGCATTCTAGTGGAATGAAATTCTACCTTTGTGAAATAATTTCAGTTTTCTTAGCC
CTAAAATGAATTATTTTAAAACATTTTCCAATGTCATTGTTACAAATACTAGAATTTAAGTGTTTCTGAAATTGGAATGTATTGCTTGTA

>In-frame_ENST00000402676_ENST00000369162_TCGA-HB-A3YV_AKAP12_chr6_151561859_+_ASCC3_chr6_100988263_length(amino acids)=406AA_start in transcript=240_stop in transcript=1460
MGAGSSTEQRSPEQPPEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPATKDAEEYTDLPVRHNEDHMNSELAKCLPIESNPHSFDS
PHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIENHHLHLFK
KWKPIMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGISVKGSWDDLVEGHNELSVSTLTADKR
DDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGRYI

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>In-frame_ENST00000253332_ENST00000369162_TCGA-HB-A3YV_AKAP12_chr6_151561859_+_ASCC3_chr6_100988263_length(transcript)=2602nt_BP=351nt
TTCTTTTAAGGAGTTTGCCGCGAGCGCGTCTCCTTCATTCGCAGGCTGGGCGCGTTCGCAGTCGGCTGGCGGCGAAGGAAGGCGCTCTCG
GGACCTCGCGGGCGCGCGTCTTTTGGCTCTTGCCCCTGTCCCTGCGGCTTGGGGAAGGCGTAACCCGGCGGCTAGGCGCGGGAGAAGTGC
GGAGGAGCCATGGGCGCCGGGAGCTCCACCGAGCAGCGCAGCCCGGAGCAGCCGCCCGAGGGGAGCTCCACGCCGGCTGAGCCCGAGCCC
AGCGGCGGCGGCCCCTCGGCCGAGGCGGCGCCAGACACCACCGCGGACCCCGCCATCGCTGCCTCGGACCCCGCCACCAAGGATGCAGAA
GAATATACAGATTTGCCAGTGAGACACAATGAAGATCATATGAATAGTGAACTGGCAAAATGTCTTCCCATTGAATCAAATCCTCATTCA
TTTGACAGCCCTCACACCAAAGCACATCTCCTGCTACAGGCACATCTCAGCCGAGCCATGCTACCCTGCCCAGATTATGACACTGATACC
AAAACAGTCTTGGACCAAGCTCTCAGAGTATGTCAGGCAATGCTGGACGTGGCTGCAAACCAGGGCTGGCTGGTGACTGTCCTGAATATC
ACCAACCTGATTCAGATGGTGATCCAGGGTCGGTGGTTAAAGGACTCTTCTCTTCTTACACTACCAAACATAGAAAACCATCATCTTCAC
CTTTTCAAGAAATGGAAGCCGATTATGAAGGGCCCACATGCTAGGGGTCGGACCTCCATCGAGTCCCTTCCTGAACTGATCCATGCCTGT
GGAGGGAAAGACCATGTATTTAGCTCCATGGTAGAAAGTGAGCTACATGCTGCAAAAACGAAACAGGCATGGAATTTCTTATCTCACTTG
CCAGTGATAAATGTTGGCATAAGTGTTAAAGGCTCGTGGGATGACTTAGTTGAAGGACATAATGAACTCTCTGTCTCAACTCTGACTGCA
GACAAACGAGATGACAACAAATGGATCAAATTGCATGCTGACCAAGAGTATGTGCTTCAAGTGAGCTTGCAGAGAGTCCACTTTGGGTTC
CACAAGGGAAAGCCAGAGAGCTGTGCAGTTACTCCTCGATTTCCCAAATCAAAAGACGAAGGATGGTTTTTGATATTAGGAGAAGTGGAT
AAGAGAGAACTTATTGCTTTGAAAAGAGTAGGATATATTCGAAATCATCATGTTGCTTCCCTTTCTTTTTATACCCCTGAAATACCTGGA
AGGTATATCTACACATTATATTTCATGAGTGACTGCTACCTTGGCCTGGACCAGCAGTATGACATCTATCTCAACGTTACACAAGCGAGT
CTTTCTGCACAGGTCAACACCAAGGTCTCTGATTCCCTGACTGACCTGGCATTAAAGTAACTTGACCTGAACAATCCATTTGAAAGGAGT
GGCTAAGAATTCTCTCTGTTCAGTCATCTAGACAAATCGAATTACTTGATGTTTGCCTTGAAAGAATCAACTTCTAACCTCAACCATCCA
GGAAATTGACAGTGGCTGCAGTATTGACTCCAGTGACATAAAGTTAACCACAGTGGCCTTTTAACAAATGTTGCCTTTTATAATGTTATC
TTTATGAGTTTCTTGATATGTAAGATGAAAAAGCATTTAGAATAATCTTTTAATTTGTGTATATTTGGGATGATATTTAGGAGCTATCAA
TCAAATTTTACATCTCACAATGTACTGTTTACATGGATATTGGCTGCTTTTTTTAAGGAAAACCACATTGAGATGTGACAAGTGTTAGGA
CTTGTCACAGATTTCTAACTCTGCCGCATAAACTATAAATCTGTAAGGTGGTACACAGCGTGTCTTGTTAGCAAAATTTATACTTTGATA
TGATCACATGTAGAAGTAGCTTCAAGAATTTCTTGTAGTCATAAATGTTTAATAATATATGATGTAAAATTATATTATGGAGCCTAATGA
TGATAACAAAGAAAACAATATACTGATCTTAGAAAATGTAGACATGGTTAACTGGGAAATAAAATATAGAGTGGCACTTCAAGACAAGCT
GACTCAATGTTTTCTTCTGCTTCCTTTAAATAATATCCCCTTACTCATCTGTTCTTCTTTTCTTTCCCTTCTACTTCAAGGCTTTATTTC
TATTATCTTTCTGACATATTTATTTACAGAAGTAGAGAAGTATAATCTAATTCATGTTGTAGCACTTACAGATCATATAGTACAATTATT
TGTCTTTATGCTCTCCAGGAAAAATCTGAGACAGAAAATTTTTCACCCCTATGGATAGGTTTTCACCTGTAATAAAGAAAATTTCTCTAT
GTCCAAACAAATTCCTTCTTGAAAAATACTTTTTCAAACTAAAAACTTGTTAAAATTCAATGTTCATATAATATGCATTCTAGTGGAATG
AAATTCTACCTTTGTGAAATAATTTCAGTTTTCTTAGCCCTAAAATGAATTATTTTAAAACATTTTCCAATGTCATTGTTACAAATACTA

>In-frame_ENST00000253332_ENST00000369162_TCGA-HB-A3YV_AKAP12_chr6_151561859_+_ASCC3_chr6_100988263_length(amino acids)=406AA_start in transcript=189_stop in transcript=1409
MGAGSSTEQRSPEQPPEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPATKDAEEYTDLPVRHNEDHMNSELAKCLPIESNPHSFDS
PHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIENHHLHLFK
KWKPIMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGISVKGSWDDLVEGHNELSVSTLTADKR
DDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGRYI

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Fusion Gene PPI Analysis for AKAP12-ASCC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKAP12-ASCC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKAP12-ASCC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKAP12C0006142Malignant neoplasm of breast1CTD_human
HgeneAKAP12C0678222Breast Carcinoma1CTD_human
HgeneAKAP12C1257931Mammary Neoplasms, Human1CTD_human
HgeneAKAP12C1458155Mammary Neoplasms1CTD_human
HgeneAKAP12C4704874Mammary Carcinoma, Human1CTD_human
TgeneASCC3C0020796Profound Mental Retardation1CTD_human
TgeneASCC3C0025363Mental Retardation, Psychosocial1CTD_human
TgeneASCC3C0917816Mental deficiency1CTD_human
TgeneASCC3C3714756Intellectual Disability1CTD_human