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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GPR110-TNFRSF21 (FusionGDB2 ID:34236)

Fusion Gene Summary for GPR110-TNFRSF21

check button Fusion gene summary
Fusion gene informationFusion gene name: GPR110-TNFRSF21
Fusion gene ID: 34236
HgeneTgene
Gene symbol

GPR110

TNFRSF21

Gene ID

266977

27242

Gene nameadhesion G protein-coupled receptor F1TNF receptor superfamily member 21
SynonymsGPR110|KPG_012|PGR19|hGPCR36BM-018|CD358|DR6
Cytomap

6p12.3|6

6p12.3

Type of geneprotein-codingprotein-coding
Descriptionadhesion G-protein coupled receptor F1G protein-coupled receptor 110G protein-coupled receptor PGR19G-protein coupled receptor KPG_012probable G-protein coupled receptor 110seven transmembrane helix receptortumor necrosis factor receptor superfamily member 21TNFR-related death receptor 6death receptor 6
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000371253, ENST00000449332, 
ENST00000283297, ENST00000371243, 
ENST00000296861, 
Fusion gene scores* DoF score3 X 6 X 3=548 X 6 X 7=336
# samples 611
** MAII scorelog2(6/54*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/336*10)=-1.6109577092541
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPR110 [Title/Abstract] AND TNFRSF21 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGPR110(47009927)-TNFRSF21(47202634), # samples:2
GPR110(46984353)-TNFRSF21(47221257), # samples:2
GPR110(46989694)-TNFRSF21(47254331), # samples:2
GPR110(46976681)-TNFRSF21(47221257), # samples:2
Anticipated loss of major functional domain due to fusion event.GPR110-TNFRSF21 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GPR110-TNFRSF21 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNFRSF21

GO:0071356

cellular response to tumor necrosis factor

19654028


check buttonFusion gene breakpoints across GPR110 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TNFRSF21 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-AA6UGPR110chr6

47009927

-TNFRSF21chr6

47202634

-
ChimerDB4BLCATCGA-FD-A62P-01AGPR110chr6

46984353

-TNFRSF21chr6

47221257

-
ChimerDB4BLCATCGA-DK-AA6SGPR110chr6

46989694

-TNFRSF21chr6

47254331

-
ChimerDB4BLCATCGA-DK-AA6SGPR110chr6

46988467

-TNFRSF21chr6

47254331

-
ChimerDB4LIHCTCGA-ED-A82E-01AGPR110chr6

46976681

-TNFRSF21chr6

47221257

-
ChimerDB4BLCATCGA-DK-AA6S-01AGPR110chr6

46989694

-TNFRSF21chr6

47254331

-
ChimerDB4BLCATCGA-DK-AA6U-01AGPR110chr6

47009927

-TNFRSF21chr6

47202634

-
ChimerDB4LIHCTCGA-ED-A82E-01AGPR110chr6

46976681

-TNFRSF21chr6

47221257

-
ChimerDB4BLCATCGA-FD-A62P-01AGPR110chr6

46984353

-TNFRSF21chr6

47221257

-


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Fusion Gene ORF analysis for GPR110-TNFRSF21

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000371253ENST00000296861GPR110chr6

47009927

-TNFRSF21chr6

47202634

-
intron-3CDSENST00000449332ENST00000296861GPR110chr6

47009927

-TNFRSF21chr6

47202634

-
intron-3CDSENST00000283297ENST00000296861GPR110chr6

47009927

-TNFRSF21chr6

47202634

-
5UTR-3CDSENST00000371243ENST00000296861GPR110chr6

47009927

-TNFRSF21chr6

47202634

-
In-frameENST00000371253ENST00000296861GPR110chr6

46984353

-TNFRSF21chr6

47221257

-
5UTR-3CDSENST00000449332ENST00000296861GPR110chr6

46984353

-TNFRSF21chr6

47221257

-
In-frameENST00000283297ENST00000296861GPR110chr6

46984353

-TNFRSF21chr6

47221257

-
intron-3CDSENST00000371243ENST00000296861GPR110chr6

46984353

-TNFRSF21chr6

47221257

-
In-frameENST00000371253ENST00000296861GPR110chr6

46989694

-TNFRSF21chr6

47254331

-
5UTR-3CDSENST00000449332ENST00000296861GPR110chr6

46989694

-TNFRSF21chr6

47254331

-
intron-3CDSENST00000283297ENST00000296861GPR110chr6

46989694

-TNFRSF21chr6

47254331

-
In-frameENST00000371243ENST00000296861GPR110chr6

46989694

-TNFRSF21chr6

47254331

-
Frame-shiftENST00000371253ENST00000296861GPR110chr6

46988467

-TNFRSF21chr6

47254331

-
5UTR-3CDSENST00000449332ENST00000296861GPR110chr6

46988467

-TNFRSF21chr6

47254331

-
intron-3CDSENST00000283297ENST00000296861GPR110chr6

46988467

-TNFRSF21chr6

47254331

-
Frame-shiftENST00000371243ENST00000296861GPR110chr6

46988467

-TNFRSF21chr6

47254331

-
Frame-shiftENST00000371253ENST00000296861GPR110chr6

46976681

-TNFRSF21chr6

47221257

-
5UTR-3CDSENST00000449332ENST00000296861GPR110chr6

46976681

-TNFRSF21chr6

47221257

-
Frame-shiftENST00000283297ENST00000296861GPR110chr6

46976681

-TNFRSF21chr6

47221257

-
intron-3CDSENST00000371243ENST00000296861GPR110chr6

46976681

-TNFRSF21chr6

47221257

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371253GPR110chr646984353-ENST00000296861TNFRSF21chr647221257-29379791921703503
ENST00000283297GPR110chr646984353-ENST00000296861TNFRSF21chr647221257-21301720896298
ENST00000371253GPR110chr646989694-ENST00000296861TNFRSF21chr647254331-38737681922639815
ENST00000371243GPR110chr646989694-ENST00000296861TNFRSF21chr647254331-38046991232570815

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371253ENST00000296861GPR110chr646984353-TNFRSF21chr647221257-0.0004325230.99956745
ENST00000283297ENST00000296861GPR110chr646984353-TNFRSF21chr647221257-0.0005567320.99944323
ENST00000371253ENST00000296861GPR110chr646989694-TNFRSF21chr647254331-0.0004650630.99953496
ENST00000371243ENST00000296861GPR110chr646989694-TNFRSF21chr647254331-0.0004313540.99956864

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Fusion Genomic Features for GPR110-TNFRSF21


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GPR110-TNFRSF21


check button Go to

FGviewer for the breakpoints of chr6:46984353-chr6:47221257

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPR110chr6:46984353chr6:47221257ENST00000371253-815148_256254.33333333333334911.0DomainSEA
TgeneTNFRSF21chr6:46984353chr6:47221257ENST0000029686126415_498414.3333333333333656.0DomainDeath
TgeneTNFRSF21chr6:46989694chr6:47254331ENST0000029686106415_49832.0656.0DomainDeath
TgeneTNFRSF21chr6:46989694chr6:47254331ENST0000029686106133_16732.0656.0RepeatNote=TNFR-Cys 3
TgeneTNFRSF21chr6:46989694chr6:47254331ENST0000029686106170_21132.0656.0RepeatNote=TNFR-Cys 4
TgeneTNFRSF21chr6:46989694chr6:47254331ENST000002968610650_8832.0656.0RepeatNote=TNFR-Cys 1
TgeneTNFRSF21chr6:46989694chr6:47254331ENST000002968610690_13132.0656.0RepeatNote=TNFR-Cys 2
TgeneTNFRSF21chr6:46989694chr6:47254331ENST0000029686106371_65532.0656.0Topological domainCytoplasmic
TgeneTNFRSF21chr6:46989694chr6:47254331ENST000002968610642_34932.0656.0Topological domainExtracellular
TgeneTNFRSF21chr6:46989694chr6:47254331ENST0000029686106350_37032.0656.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPR110chr6:46984353chr6:47221257ENST00000283297-29148_25657.333333333333336714.0DomainSEA
HgeneGPR110chr6:46984353chr6:47221257ENST00000283297-29531_57857.333333333333336714.0DomainGPS
HgeneGPR110chr6:46984353chr6:47221257ENST00000371243-18148_2560219.0DomainSEA
HgeneGPR110chr6:46984353chr6:47221257ENST00000371243-18531_5780219.0DomainGPS
HgeneGPR110chr6:46984353chr6:47221257ENST00000371253-815531_578254.33333333333334911.0DomainGPS
HgeneGPR110chr6:46989694chr6:47254331ENST00000283297-19148_2560.0714.0DomainSEA
HgeneGPR110chr6:46989694chr6:47254331ENST00000283297-19531_5780.0714.0DomainGPS
HgeneGPR110chr6:46989694chr6:47254331ENST00000371243-68148_256184.0219.0DomainSEA
HgeneGPR110chr6:46989694chr6:47254331ENST00000371243-68531_578184.0219.0DomainGPS
HgeneGPR110chr6:46989694chr6:47254331ENST00000371253-615148_256184.0911.0DomainSEA
HgeneGPR110chr6:46989694chr6:47254331ENST00000371253-615531_578184.0911.0DomainGPS
HgeneGPR110chr6:46984353chr6:47221257ENST00000283297-2920_59057.333333333333336714.0Topological domainExtracellular
HgeneGPR110chr6:46984353chr6:47221257ENST00000283297-29612_62457.333333333333336714.0Topological domainCytoplasmic
HgeneGPR110chr6:46984353chr6:47221257ENST00000283297-29646_66057.333333333333336714.0Topological domainExtracellular
HgeneGPR110chr6:46984353chr6:47221257ENST00000283297-29682_69957.333333333333336714.0Topological domainCytoplasmic
HgeneGPR110chr6:46984353chr6:47221257ENST00000283297-29721_74457.333333333333336714.0Topological domainExtracellular
HgeneGPR110chr6:46984353chr6:47221257ENST00000283297-29766_79157.333333333333336714.0Topological domainCytoplasmic
HgeneGPR110chr6:46984353chr6:47221257ENST00000283297-29813_82057.333333333333336714.0Topological domainExtracellular
HgeneGPR110chr6:46984353chr6:47221257ENST00000283297-29842_91057.333333333333336714.0Topological domainCytoplasmic
HgeneGPR110chr6:46984353chr6:47221257ENST00000371243-1820_5900219.0Topological domainExtracellular
HgeneGPR110chr6:46984353chr6:47221257ENST00000371243-18612_6240219.0Topological domainCytoplasmic
HgeneGPR110chr6:46984353chr6:47221257ENST00000371243-18646_6600219.0Topological domainExtracellular
HgeneGPR110chr6:46984353chr6:47221257ENST00000371243-18682_6990219.0Topological domainCytoplasmic
HgeneGPR110chr6:46984353chr6:47221257ENST00000371243-18721_7440219.0Topological domainExtracellular
HgeneGPR110chr6:46984353chr6:47221257ENST00000371243-18766_7910219.0Topological domainCytoplasmic
HgeneGPR110chr6:46984353chr6:47221257ENST00000371243-18813_8200219.0Topological domainExtracellular
HgeneGPR110chr6:46984353chr6:47221257ENST00000371243-18842_9100219.0Topological domainCytoplasmic
HgeneGPR110chr6:46984353chr6:47221257ENST00000371253-81520_590254.33333333333334911.0Topological domainExtracellular
HgeneGPR110chr6:46984353chr6:47221257ENST00000371253-815612_624254.33333333333334911.0Topological domainCytoplasmic
HgeneGPR110chr6:46984353chr6:47221257ENST00000371253-815646_660254.33333333333334911.0Topological domainExtracellular
HgeneGPR110chr6:46984353chr6:47221257ENST00000371253-815682_699254.33333333333334911.0Topological domainCytoplasmic
HgeneGPR110chr6:46984353chr6:47221257ENST00000371253-815721_744254.33333333333334911.0Topological domainExtracellular
HgeneGPR110chr6:46984353chr6:47221257ENST00000371253-815766_791254.33333333333334911.0Topological domainCytoplasmic
HgeneGPR110chr6:46984353chr6:47221257ENST00000371253-815813_820254.33333333333334911.0Topological domainExtracellular
HgeneGPR110chr6:46984353chr6:47221257ENST00000371253-815842_910254.33333333333334911.0Topological domainCytoplasmic
HgeneGPR110chr6:46989694chr6:47254331ENST00000283297-1920_5900.0714.0Topological domainExtracellular
HgeneGPR110chr6:46989694chr6:47254331ENST00000283297-19612_6240.0714.0Topological domainCytoplasmic
HgeneGPR110chr6:46989694chr6:47254331ENST00000283297-19646_6600.0714.0Topological domainExtracellular
HgeneGPR110chr6:46989694chr6:47254331ENST00000283297-19682_6990.0714.0Topological domainCytoplasmic
HgeneGPR110chr6:46989694chr6:47254331ENST00000283297-19721_7440.0714.0Topological domainExtracellular
HgeneGPR110chr6:46989694chr6:47254331ENST00000283297-19766_7910.0714.0Topological domainCytoplasmic
HgeneGPR110chr6:46989694chr6:47254331ENST00000283297-19813_8200.0714.0Topological domainExtracellular
HgeneGPR110chr6:46989694chr6:47254331ENST00000283297-19842_9100.0714.0Topological domainCytoplasmic
HgeneGPR110chr6:46989694chr6:47254331ENST00000371243-6820_590184.0219.0Topological domainExtracellular
HgeneGPR110chr6:46989694chr6:47254331ENST00000371243-68612_624184.0219.0Topological domainCytoplasmic
HgeneGPR110chr6:46989694chr6:47254331ENST00000371243-68646_660184.0219.0Topological domainExtracellular
HgeneGPR110chr6:46989694chr6:47254331ENST00000371243-68682_699184.0219.0Topological domainCytoplasmic
HgeneGPR110chr6:46989694chr6:47254331ENST00000371243-68721_744184.0219.0Topological domainExtracellular
HgeneGPR110chr6:46989694chr6:47254331ENST00000371243-68766_791184.0219.0Topological domainCytoplasmic
HgeneGPR110chr6:46989694chr6:47254331ENST00000371243-68813_820184.0219.0Topological domainExtracellular
HgeneGPR110chr6:46989694chr6:47254331ENST00000371243-68842_910184.0219.0Topological domainCytoplasmic
HgeneGPR110chr6:46989694chr6:47254331ENST00000371253-61520_590184.0911.0Topological domainExtracellular
HgeneGPR110chr6:46989694chr6:47254331ENST00000371253-615612_624184.0911.0Topological domainCytoplasmic
HgeneGPR110chr6:46989694chr6:47254331ENST00000371253-615646_660184.0911.0Topological domainExtracellular
HgeneGPR110chr6:46989694chr6:47254331ENST00000371253-615682_699184.0911.0Topological domainCytoplasmic
HgeneGPR110chr6:46989694chr6:47254331ENST00000371253-615721_744184.0911.0Topological domainExtracellular
HgeneGPR110chr6:46989694chr6:47254331ENST00000371253-615766_791184.0911.0Topological domainCytoplasmic
HgeneGPR110chr6:46989694chr6:47254331ENST00000371253-615813_820184.0911.0Topological domainExtracellular
HgeneGPR110chr6:46989694chr6:47254331ENST00000371253-615842_910184.0911.0Topological domainCytoplasmic
HgeneGPR110chr6:46984353chr6:47221257ENST00000283297-29591_61157.333333333333336714.0TransmembraneHelical%3B Name%3D1
HgeneGPR110chr6:46984353chr6:47221257ENST00000283297-29625_64557.333333333333336714.0TransmembraneHelical%3B Name%3D2
HgeneGPR110chr6:46984353chr6:47221257ENST00000283297-29661_68157.333333333333336714.0TransmembraneHelical%3B Name%3D3
HgeneGPR110chr6:46984353chr6:47221257ENST00000283297-29700_72057.333333333333336714.0TransmembraneHelical%3B Name%3D4
HgeneGPR110chr6:46984353chr6:47221257ENST00000283297-29745_76557.333333333333336714.0TransmembraneHelical%3B Name%3D5
HgeneGPR110chr6:46984353chr6:47221257ENST00000283297-29792_81257.333333333333336714.0TransmembraneHelical%3B Name%3D6
HgeneGPR110chr6:46984353chr6:47221257ENST00000283297-29821_84157.333333333333336714.0TransmembraneHelical%3B Name%3D7
HgeneGPR110chr6:46984353chr6:47221257ENST00000371243-18591_6110219.0TransmembraneHelical%3B Name%3D1
HgeneGPR110chr6:46984353chr6:47221257ENST00000371243-18625_6450219.0TransmembraneHelical%3B Name%3D2
HgeneGPR110chr6:46984353chr6:47221257ENST00000371243-18661_6810219.0TransmembraneHelical%3B Name%3D3
HgeneGPR110chr6:46984353chr6:47221257ENST00000371243-18700_7200219.0TransmembraneHelical%3B Name%3D4
HgeneGPR110chr6:46984353chr6:47221257ENST00000371243-18745_7650219.0TransmembraneHelical%3B Name%3D5
HgeneGPR110chr6:46984353chr6:47221257ENST00000371243-18792_8120219.0TransmembraneHelical%3B Name%3D6
HgeneGPR110chr6:46984353chr6:47221257ENST00000371243-18821_8410219.0TransmembraneHelical%3B Name%3D7
HgeneGPR110chr6:46984353chr6:47221257ENST00000371253-815591_611254.33333333333334911.0TransmembraneHelical%3B Name%3D1
HgeneGPR110chr6:46984353chr6:47221257ENST00000371253-815625_645254.33333333333334911.0TransmembraneHelical%3B Name%3D2
HgeneGPR110chr6:46984353chr6:47221257ENST00000371253-815661_681254.33333333333334911.0TransmembraneHelical%3B Name%3D3
HgeneGPR110chr6:46984353chr6:47221257ENST00000371253-815700_720254.33333333333334911.0TransmembraneHelical%3B Name%3D4
HgeneGPR110chr6:46984353chr6:47221257ENST00000371253-815745_765254.33333333333334911.0TransmembraneHelical%3B Name%3D5
HgeneGPR110chr6:46984353chr6:47221257ENST00000371253-815792_812254.33333333333334911.0TransmembraneHelical%3B Name%3D6
HgeneGPR110chr6:46984353chr6:47221257ENST00000371253-815821_841254.33333333333334911.0TransmembraneHelical%3B Name%3D7
HgeneGPR110chr6:46989694chr6:47254331ENST00000283297-19591_6110.0714.0TransmembraneHelical%3B Name%3D1
HgeneGPR110chr6:46989694chr6:47254331ENST00000283297-19625_6450.0714.0TransmembraneHelical%3B Name%3D2
HgeneGPR110chr6:46989694chr6:47254331ENST00000283297-19661_6810.0714.0TransmembraneHelical%3B Name%3D3
HgeneGPR110chr6:46989694chr6:47254331ENST00000283297-19700_7200.0714.0TransmembraneHelical%3B Name%3D4
HgeneGPR110chr6:46989694chr6:47254331ENST00000283297-19745_7650.0714.0TransmembraneHelical%3B Name%3D5
HgeneGPR110chr6:46989694chr6:47254331ENST00000283297-19792_8120.0714.0TransmembraneHelical%3B Name%3D6
HgeneGPR110chr6:46989694chr6:47254331ENST00000283297-19821_8410.0714.0TransmembraneHelical%3B Name%3D7
HgeneGPR110chr6:46989694chr6:47254331ENST00000371243-68591_611184.0219.0TransmembraneHelical%3B Name%3D1
HgeneGPR110chr6:46989694chr6:47254331ENST00000371243-68625_645184.0219.0TransmembraneHelical%3B Name%3D2
HgeneGPR110chr6:46989694chr6:47254331ENST00000371243-68661_681184.0219.0TransmembraneHelical%3B Name%3D3
HgeneGPR110chr6:46989694chr6:47254331ENST00000371243-68700_720184.0219.0TransmembraneHelical%3B Name%3D4
HgeneGPR110chr6:46989694chr6:47254331ENST00000371243-68745_765184.0219.0TransmembraneHelical%3B Name%3D5
HgeneGPR110chr6:46989694chr6:47254331ENST00000371243-68792_812184.0219.0TransmembraneHelical%3B Name%3D6
HgeneGPR110chr6:46989694chr6:47254331ENST00000371243-68821_841184.0219.0TransmembraneHelical%3B Name%3D7
HgeneGPR110chr6:46989694chr6:47254331ENST00000371253-615591_611184.0911.0TransmembraneHelical%3B Name%3D1
HgeneGPR110chr6:46989694chr6:47254331ENST00000371253-615625_645184.0911.0TransmembraneHelical%3B Name%3D2
HgeneGPR110chr6:46989694chr6:47254331ENST00000371253-615661_681184.0911.0TransmembraneHelical%3B Name%3D3
HgeneGPR110chr6:46989694chr6:47254331ENST00000371253-615700_720184.0911.0TransmembraneHelical%3B Name%3D4
HgeneGPR110chr6:46989694chr6:47254331ENST00000371253-615745_765184.0911.0TransmembraneHelical%3B Name%3D5
HgeneGPR110chr6:46989694chr6:47254331ENST00000371253-615792_812184.0911.0TransmembraneHelical%3B Name%3D6
HgeneGPR110chr6:46989694chr6:47254331ENST00000371253-615821_841184.0911.0TransmembraneHelical%3B Name%3D7
TgeneTNFRSF21chr6:46984353chr6:47221257ENST0000029686126133_167414.3333333333333656.0RepeatNote=TNFR-Cys 3
TgeneTNFRSF21chr6:46984353chr6:47221257ENST0000029686126170_211414.3333333333333656.0RepeatNote=TNFR-Cys 4
TgeneTNFRSF21chr6:46984353chr6:47221257ENST000002968612650_88414.3333333333333656.0RepeatNote=TNFR-Cys 1
TgeneTNFRSF21chr6:46984353chr6:47221257ENST000002968612690_131414.3333333333333656.0RepeatNote=TNFR-Cys 2
TgeneTNFRSF21chr6:46984353chr6:47221257ENST0000029686126371_655414.3333333333333656.0Topological domainCytoplasmic
TgeneTNFRSF21chr6:46984353chr6:47221257ENST000002968612642_349414.3333333333333656.0Topological domainExtracellular
TgeneTNFRSF21chr6:46984353chr6:47221257ENST0000029686126350_370414.3333333333333656.0TransmembraneHelical


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Fusion Gene Sequence for GPR110-TNFRSF21


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000371253_ENST00000296861_TCGA-FD-A62P-01A_GPR110_chr6_46984353_-_TNFRSF21_chr6_47221257_length(transcript)=2937nt_BP=979nt
AGTAATGCGTGCCAGGAATTGCTGATGGATCAGTGAGCCTGTGTTCATGCCAGTGAGCTGCTGTGGCTCAGATACTGATACTTTCTTTCC
AAACAGCATAAGAAGTGATTGAGCCACAAGTATACTGAAGGAAGGGCTCCCTCGAGTTCTGGTGTGAAGAGATAAATCACCAGTCACAGA
CTATGCACCCGACTGCTGCTGTTCAGTCCAGGGAAAATGAAAGTTGGAGTGCTGTGGCTCATTTCTTTCTTCACCTTCACTGACGGCCAC
GGTGGCTTCCTGGGGAAAAATGATGGCATCAAAACAAAAAAAGAACTCATTGTGAATAAGAAAAAACATCTAGGCCCAGTCGAAGAATAT
CAGCTGCTGCTTCAGGTGACCTATAGAGATTCCAAGGAGAAAAGAGATTTGAGAAATTTTCTGAAGCTCTTGAAGCCTCCATTATTATGG
TCACATGGGCTAATTAGAATTATCAGAGCAAAGGCTACCACAGACTGCAACAGCCTGAATGGAGTCCTGCAGTGTACCTGTGAAGACAGC
TACACCTGGTTTCCTCCCTCATGCCTTGATCCCCAGAACTGCTACCTTCACACGGCTGGAGCACTCCCAAGCTGTGAATGTCATCTCAAC
AACCTCAGCCAGAGTGTCAATTTCTGTGAGAGAACAAAGATTTGGGGCACTTTCAAAATTAATGAAAGGTTTACAAATGACCTTTTGAAT
TCATCTTCTGCTATATACTCCAAATATGCAAATGGAATTGAAATTCAACTTAAAAAAGCATATGAAAGAATTCAAGGTTTTGAGTCGGTT
CAGGTCACCCAATTTCGAAATGGAAGCATCGTTGCTGGGTATGAAGTTGTTGGCTCCAGCAGTGCATCTGAACTGCTGTCAGCCATTGAA
CATGTTGCCGAGAAGGCTAAGACAGCCCTTCACAAGCTGTTTCCATTAGAAGACGGCTCTTTCAGAGTGTTCGGAAAAGGTATCGATATC
CTGAAGCTTGTAGCAGCCCAAGTGGGAAGCCAGTGGAAAGATATCTATCAGTTTCTTTGCAATGCCAGTGAGAGGGAGGTTGCTGCTTTC
TCCAATGGGTACACAGCCGACCACGAGCGGGCCTACGCAGCTCTGCAGCACTGGACCATCCGGGGCCCCGAGGCCAGCCTCGCCCAGCTA
ATTAGCGCCCTGCGCCAGCACCGGAGAAACGATGTTGTGGAGAAGATTCGTGGGCTGATGGAAGACACCACCCAGCTGGAAACTGACAAA
CTAGCTCTCCCGATGAGCCCCAGCCCGCTTAGCCCGAGCCCCATCCCCAGCCCCAACGCGAAACTTGAGAATTCCGCTCTCCTGACGGTG
GAGCCTTCCCCACAGGACAAGAACAAGGGCTTCTTCGTGGATGAGTCGGAGCCCCTTCTCCGCTGTGACTCTACATCCAGCGGCTCCTCC
GCGCTGAGCAGGAACGGTTCCTTTATTACCAAAGAAAAGAAGGACACAGTGTTGCGGCAGGTACGCCTGGACCCCTGTGACTTGCAGCCT
ATCTTTGATGACATGCTCCACTTTCTAAATCCTGAGGAGCTGCGGGTGATTGAAGAGATTCCCCAGGCTGAGGACAAACTAGACCGGCTA
TTCGAAATTATTGGAGTCAAGAGCCAGGAAGCCAGCCAGACCCTCCTGGACTCTGTTTATAGCCATCTTCCTGACCTGCTGTAGAACATA
GGGATACTGCATTCTGGAAATTACTCAATTTAGTGGCAGGGTGGTTTTTTAATTTTCTTCTGTTTCTGATTTTTGTTGTTTGGGGTGTGT
GTGTGTGTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTAACAGAGAATATGGCCAGTGCTTGAGTTCTTTCTCCTTCTCTCT
CTCTCTTTTTTTTTTAAATAACTCTTCTGGGAAGTTGGTTTATAAGCCTTTGCCAGGTGTAACTGTTGTGAAATACCCACCACTAAAGTT
TTTTAAGTTCCATATTTTCTCCATTTTGCCTTCTTATGTATTTTCAAGATTATTCTGTGCACTTTAAATTTACTTAACTTACCATAAATG
CAGTGTGACTTTTCCCACACACTGGATTGTGAGGCTCTTAACTTCTTAAAAGTATAATGGCATCTTGTGAATCCTATAAGCAGTCTTTAT
GTCTCTTAACATTCACACCTACTTTTTAAAAACAAATATTATTACTATTTTTATTATTGTTTGTCCTTTATAAATTTTCTTAAAGATTAA
GAAAATTTAAGACCCCATTGAGTTACTGTAATGCAATTCAACTTTGAGTTATCTTTTAAATATGTCTTGTATAGTTCATATTCATGGCTG
AAACTTGACCACACTATTGCTGATTGTATGGTTTTCACCTGGACACCGTGTAGAATGCTTGATTACTTGTACTCTTCTTATGCTAATATG
CTCTGGGCTGGAGAAATGAAATCCTCAAGCCATCAGGATTTGCTATTTAAGTGGCTTGACAACTGGGCCACCAAAGAACTTGAACTTCAC
CTTTTAGGATTTGAGCTGTTCTGGAACACATTGCTGCACTTTGGAAAGTCAAAATCAAGTGCCAGTGGCGCCCTTTCCATAGAGAATTTG
CCCAGCTTTGCTTTAAAAGATGTCTTGTTTTTTATATACACATAATCAATAGGTCCAATCTGCTCTCAAGGCCTTGGTCCTGGTGGGATT
CCTTCACCAATTACTTTAATTAAAAATGGCTGCAACTGTAAGAACCCTTGTCTGATATATTTGCAACTATGCTCCCATTTACAAATGTAC
CTTCTAATGCTCAGTTGCCAGGTTCCAATGCAAAGGTGGCGTGGACTCCCTTTGTGTGGGTGGGGTTTGTGGGTAGTGGTGAAGGACCGA

>In-frame_ENST00000371253_ENST00000296861_TCGA-FD-A62P-01A_GPR110_chr6_46984353_-_TNFRSF21_chr6_47221257_length(amino acids)=503AA_start in transcript=192_stop in transcript=1703
MLLFSPGKMKVGVLWLISFFTFTDGHGGFLGKNDGIKTKKELIVNKKKHLGPVEEYQLLLQVTYRDSKEKRDLRNFLKLLKPPLLWSHGL
IRIIRAKATTDCNSLNGVLQCTCEDSYTWFPPSCLDPQNCYLHTAGALPSCECHLNNLSQSVNFCERTKIWGTFKINERFTNDLLNSSSA
IYSKYANGIEIQLKKAYERIQGFESVQVTQFRNGSIVAGYEVVGSSSASELLSAIEHVAEKAKTALHKLFPLEDGSFRVFGKGIDILKLV
AAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDKLALP
MSPSPLSPSPIPSPNAKLENSALLTVEPSPQDKNKGFFVDESEPLLRCDSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDD

--------------------------------------------------------------
>In-frame_ENST00000283297_ENST00000296861_TCGA-FD-A62P-01A_GPR110_chr6_46984353_-_TNFRSF21_chr6_47221257_length(transcript)=2130nt_BP=172nt
ATGGACATATCAATACAAAGAAATGGAAGCATCGTTGCTGGGTATGAAGTTGTTGGCTCCAGCAGTGCATCTGAACTGCTGTCAGCCATT
GAACATGTTGCCGAGAAGGCTAAGACAGCCCTTCACAAGCTGTTTCCATTAGAAGACGGCTCTTTCAGAGTGTTCGGAAAAGGTATCGAT
ATCCTGAAGCTTGTAGCAGCCCAAGTGGGAAGCCAGTGGAAAGATATCTATCAGTTTCTTTGCAATGCCAGTGAGAGGGAGGTTGCTGCT
TTCTCCAATGGGTACACAGCCGACCACGAGCGGGCCTACGCAGCTCTGCAGCACTGGACCATCCGGGGCCCCGAGGCCAGCCTCGCCCAG
CTAATTAGCGCCCTGCGCCAGCACCGGAGAAACGATGTTGTGGAGAAGATTCGTGGGCTGATGGAAGACACCACCCAGCTGGAAACTGAC
AAACTAGCTCTCCCGATGAGCCCCAGCCCGCTTAGCCCGAGCCCCATCCCCAGCCCCAACGCGAAACTTGAGAATTCCGCTCTCCTGACG
GTGGAGCCTTCCCCACAGGACAAGAACAAGGGCTTCTTCGTGGATGAGTCGGAGCCCCTTCTCCGCTGTGACTCTACATCCAGCGGCTCC
TCCGCGCTGAGCAGGAACGGTTCCTTTATTACCAAAGAAAAGAAGGACACAGTGTTGCGGCAGGTACGCCTGGACCCCTGTGACTTGCAG
CCTATCTTTGATGACATGCTCCACTTTCTAAATCCTGAGGAGCTGCGGGTGATTGAAGAGATTCCCCAGGCTGAGGACAAACTAGACCGG
CTATTCGAAATTATTGGAGTCAAGAGCCAGGAAGCCAGCCAGACCCTCCTGGACTCTGTTTATAGCCATCTTCCTGACCTGCTGTAGAAC
ATAGGGATACTGCATTCTGGAAATTACTCAATTTAGTGGCAGGGTGGTTTTTTAATTTTCTTCTGTTTCTGATTTTTGTTGTTTGGGGTG
TGTGTGTGTGTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTAACAGAGAATATGGCCAGTGCTTGAGTTCTTTCTCCTTCTC
TCTCTCTCTTTTTTTTTTAAATAACTCTTCTGGGAAGTTGGTTTATAAGCCTTTGCCAGGTGTAACTGTTGTGAAATACCCACCACTAAA
GTTTTTTAAGTTCCATATTTTCTCCATTTTGCCTTCTTATGTATTTTCAAGATTATTCTGTGCACTTTAAATTTACTTAACTTACCATAA
ATGCAGTGTGACTTTTCCCACACACTGGATTGTGAGGCTCTTAACTTCTTAAAAGTATAATGGCATCTTGTGAATCCTATAAGCAGTCTT
TATGTCTCTTAACATTCACACCTACTTTTTAAAAACAAATATTATTACTATTTTTATTATTGTTTGTCCTTTATAAATTTTCTTAAAGAT
TAAGAAAATTTAAGACCCCATTGAGTTACTGTAATGCAATTCAACTTTGAGTTATCTTTTAAATATGTCTTGTATAGTTCATATTCATGG
CTGAAACTTGACCACACTATTGCTGATTGTATGGTTTTCACCTGGACACCGTGTAGAATGCTTGATTACTTGTACTCTTCTTATGCTAAT
ATGCTCTGGGCTGGAGAAATGAAATCCTCAAGCCATCAGGATTTGCTATTTAAGTGGCTTGACAACTGGGCCACCAAAGAACTTGAACTT
CACCTTTTAGGATTTGAGCTGTTCTGGAACACATTGCTGCACTTTGGAAAGTCAAAATCAAGTGCCAGTGGCGCCCTTTCCATAGAGAAT
TTGCCCAGCTTTGCTTTAAAAGATGTCTTGTTTTTTATATACACATAATCAATAGGTCCAATCTGCTCTCAAGGCCTTGGTCCTGGTGGG
ATTCCTTCACCAATTACTTTAATTAAAAATGGCTGCAACTGTAAGAACCCTTGTCTGATATATTTGCAACTATGCTCCCATTTACAAATG
TACCTTCTAATGCTCAGTTGCCAGGTTCCAATGCAAAGGTGGCGTGGACTCCCTTTGTGTGGGTGGGGTTTGTGGGTAGTGGTGAAGGAC

>In-frame_ENST00000283297_ENST00000296861_TCGA-FD-A62P-01A_GPR110_chr6_46984353_-_TNFRSF21_chr6_47221257_length(amino acids)=298AA_start in transcript=0_stop in transcript=896
MDISIQRNGSIVAGYEVVGSSSASELLSAIEHVAEKAKTALHKLFPLEDGSFRVFGKGIDILKLVAAQVGSQWKDIYQFLCNASEREVAA
FSNGYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDKLALPMSPSPLSPSPIPSPNAKLENSALLT
VEPSPQDKNKGFFVDESEPLLRCDSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHFLNPEELRVIEEIPQAEDKLDR

--------------------------------------------------------------
>In-frame_ENST00000371253_ENST00000296861_TCGA-DK-AA6S_GPR110_chr6_46989694_-_TNFRSF21_chr6_47254331_length(transcript)=3873nt_BP=768nt
AGTAATGCGTGCCAGGAATTGCTGATGGATCAGTGAGCCTGTGTTCATGCCAGTGAGCTGCTGTGGCTCAGATACTGATACTTTCTTTCC
AAACAGCATAAGAAGTGATTGAGCCACAAGTATACTGAAGGAAGGGCTCCCTCGAGTTCTGGTGTGAAGAGATAAATCACCAGTCACAGA
CTATGCACCCGACTGCTGCTGTTCAGTCCAGGGAAAATGAAAGTTGGAGTGCTGTGGCTCATTTCTTTCTTCACCTTCACTGACGGCCAC
GGTGGCTTCCTGGGGAAAAATGATGGCATCAAAACAAAAAAAGAACTCATTGTGAATAAGAAAAAACATCTAGGCCCAGTCGAAGAATAT
CAGCTGCTGCTTCAGGTGACCTATAGAGATTCCAAGGAGAAAAGAGATTTGAGAAATTTTCTGAAGCTCTTGAAGCCTCCATTATTATGG
TCACATGGGCTAATTAGAATTATCAGAGCAAAGGCTACCACAGACTGCAACAGCCTGAATGGAGTCCTGCAGTGTACCTGTGAAGACAGC
TACACCTGGTTTCCTCCCTCATGCCTTGATCCCCAGAACTGCTACCTTCACACGGCTGGAGCACTCCCAAGCTGTGAATGTCATCTCAAC
AACCTCAGCCAGAGTGTCAATTTCTGTGAGAGAACAAAGATTTGGGGCACTTTCAAAATTAATGAAAGGTTTACAAATGACCTTTTGAAT
TCATCTTCTGCTATATACTCCAAATATGCAAATGGAATTGAAATTCAACTTGGATTCCTTAGCACCACCACAGCTCAGCCAGAACAGAAG
GCCTCGAATCTCATTGGCACATACCGCCATGTTGACCGTGCCACCGGCCAGGTGCTAACCTGTGACAAGTGTCCAGCAGGAACCTATGTC
TCTGAGCATTGTACCAACACAAGCCTGCGCGTCTGCAGCAGTTGCCCTGTGGGGACCTTTACCAGGCATGAGAATGGCATAGAGAAATGC
CATGACTGTAGTCAGCCATGCCCATGGCCAATGATTGAGAAATTACCTTGTGCTGCCTTGACTGACCGAGAATGCACTTGCCCACCTGGC
ATGTTCCAGTCTAACGCTACCTGTGCCCCCCATACGGTGTGTCCTGTGGGTTGGGGTGTGCGGAAGAAAGGGACAGAGACTGAGGATGTG
CGGTGTAAGCAGTGTGCTCGGGGTACCTTCTCAGATGTGCCTTCTAGTGTGATGAAATGCAAAGCATACACAGACTGTCTGAGTCAGAAC
CTGGTGGTGATCAAGCCGGGGACCAAGGAGACAGACAACGTCTGTGGCACACTCCCGTCCTTCTCCAGCTCCACCTCACCTTCCCCTGGC
ACAGCCATCTTTCCACGCCCTGAGCACATGGAAACCCATGAAGTCCCTTCCTCCACTTATGTTCCCAAAGGCATGAACTCAACAGAATCC
AACTCTTCTGCCTCTGTTAGACCAAAGGTACTGAGTAGCATCCAGGAAGGGACAGTCCCTGACAACACAAGCTCAGCAAGGGGGAAGGAA
GACGTGAACAAGACCCTCCCAAACCTTCAGGTAGTCAACCACCAGCAAGGCCCCCACCACAGACACATCCTGAAGCTGCTGCCGTCCATG
GAGGCCACTGGGGGCGAGAAGTCCAGCACGCCCATCAAGGGCCCCAAGAGGGGACATCCTAGACAGAACCTACACAAGCATTTTGACATC
AATGAGCATTTGCCCTGGATGATTGTGCTTTTCCTGCTGCTGGTGCTTGTGGTGATTGTGGTGTGCAGTATCCGGAAAAGCTCGAGGACT
CTGAAAAAGGGGCCCCGGCAGGATCCCAGTGCCATTGTGGAAAAGGCAGGGCTGAAGAAATCCATGACTCCAACCCAGAACCGGGAGAAA
TGGATCTACTACTGCAATGGCCATGGTATCGATATCCTGAAGCTTGTAGCAGCCCAAGTGGGAAGCCAGTGGAAAGATATCTATCAGTTT
CTTTGCAATGCCAGTGAGAGGGAGGTTGCTGCTTTCTCCAATGGGTACACAGCCGACCACGAGCGGGCCTACGCAGCTCTGCAGCACTGG
ACCATCCGGGGCCCCGAGGCCAGCCTCGCCCAGCTAATTAGCGCCCTGCGCCAGCACCGGAGAAACGATGTTGTGGAGAAGATTCGTGGG
CTGATGGAAGACACCACCCAGCTGGAAACTGACAAACTAGCTCTCCCGATGAGCCCCAGCCCGCTTAGCCCGAGCCCCATCCCCAGCCCC
AACGCGAAACTTGAGAATTCCGCTCTCCTGACGGTGGAGCCTTCCCCACAGGACAAGAACAAGGGCTTCTTCGTGGATGAGTCGGAGCCC
CTTCTCCGCTGTGACTCTACATCCAGCGGCTCCTCCGCGCTGAGCAGGAACGGTTCCTTTATTACCAAAGAAAAGAAGGACACAGTGTTG
CGGCAGGTACGCCTGGACCCCTGTGACTTGCAGCCTATCTTTGATGACATGCTCCACTTTCTAAATCCTGAGGAGCTGCGGGTGATTGAA
GAGATTCCCCAGGCTGAGGACAAACTAGACCGGCTATTCGAAATTATTGGAGTCAAGAGCCAGGAAGCCAGCCAGACCCTCCTGGACTCT
GTTTATAGCCATCTTCCTGACCTGCTGTAGAACATAGGGATACTGCATTCTGGAAATTACTCAATTTAGTGGCAGGGTGGTTTTTTAATT
TTCTTCTGTTTCTGATTTTTGTTGTTTGGGGTGTGTGTGTGTGTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTAACAGAGA
ATATGGCCAGTGCTTGAGTTCTTTCTCCTTCTCTCTCTCTCTTTTTTTTTTAAATAACTCTTCTGGGAAGTTGGTTTATAAGCCTTTGCC
AGGTGTAACTGTTGTGAAATACCCACCACTAAAGTTTTTTAAGTTCCATATTTTCTCCATTTTGCCTTCTTATGTATTTTCAAGATTATT
CTGTGCACTTTAAATTTACTTAACTTACCATAAATGCAGTGTGACTTTTCCCACACACTGGATTGTGAGGCTCTTAACTTCTTAAAAGTA
TAATGGCATCTTGTGAATCCTATAAGCAGTCTTTATGTCTCTTAACATTCACACCTACTTTTTAAAAACAAATATTATTACTATTTTTAT
TATTGTTTGTCCTTTATAAATTTTCTTAAAGATTAAGAAAATTTAAGACCCCATTGAGTTACTGTAATGCAATTCAACTTTGAGTTATCT
TTTAAATATGTCTTGTATAGTTCATATTCATGGCTGAAACTTGACCACACTATTGCTGATTGTATGGTTTTCACCTGGACACCGTGTAGA
ATGCTTGATTACTTGTACTCTTCTTATGCTAATATGCTCTGGGCTGGAGAAATGAAATCCTCAAGCCATCAGGATTTGCTATTTAAGTGG
CTTGACAACTGGGCCACCAAAGAACTTGAACTTCACCTTTTAGGATTTGAGCTGTTCTGGAACACATTGCTGCACTTTGGAAAGTCAAAA
TCAAGTGCCAGTGGCGCCCTTTCCATAGAGAATTTGCCCAGCTTTGCTTTAAAAGATGTCTTGTTTTTTATATACACATAATCAATAGGT
CCAATCTGCTCTCAAGGCCTTGGTCCTGGTGGGATTCCTTCACCAATTACTTTAATTAAAAATGGCTGCAACTGTAAGAACCCTTGTCTG
ATATATTTGCAACTATGCTCCCATTTACAAATGTACCTTCTAATGCTCAGTTGCCAGGTTCCAATGCAAAGGTGGCGTGGACTCCCTTTG
TGTGGGTGGGGTTTGTGGGTAGTGGTGAAGGACCGATATCAGAAAAATGCCTTCAAGTGTACTAATTTATTAATAAACATTAGGTGTTTG

>In-frame_ENST00000371253_ENST00000296861_TCGA-DK-AA6S_GPR110_chr6_46989694_-_TNFRSF21_chr6_47254331_length(amino acids)=815AA_start in transcript=192_stop in transcript=2639
MLLFSPGKMKVGVLWLISFFTFTDGHGGFLGKNDGIKTKKELIVNKKKHLGPVEEYQLLLQVTYRDSKEKRDLRNFLKLLKPPLLWSHGL
IRIIRAKATTDCNSLNGVLQCTCEDSYTWFPPSCLDPQNCYLHTAGALPSCECHLNNLSQSVNFCERTKIWGTFKINERFTNDLLNSSSA
IYSKYANGIEIQLGFLSTTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENGIEKCHDCS
QPCPWPMIEKLPCAALTDRECTCPPGMFQSNATCAPHTVCPVGWGVRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVI
KPGTKETDNVCGTLPSFSSSTSPSPGTAIFPRPEHMETHEVPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVPDNTSSARGKEDVNK
TLPNLQVVNHQQGPHHRHILKLLPSMEATGGEKSSTPIKGPKRGHPRQNLHKHFDINEHLPWMIVLFLLLVLVVIVVCSIRKSSRTLKKG
PRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRG
PEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDKLALPMSPSPLSPSPIPSPNAKLENSALLTVEPSPQDKNKGFFVDESEPLLRC
DSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHFLNPEELRVIEEIPQAEDKLDRLFEIIGVKSQEASQTLLDSVYSH

--------------------------------------------------------------
>In-frame_ENST00000371243_ENST00000296861_TCGA-DK-AA6S_GPR110_chr6_46989694_-_TNFRSF21_chr6_47254331_length(transcript)=3804nt_BP=699nt
AGATACTGATACTTTCTTTCCAAACAGCATAAGAAGTGATTGAGCCACAAGTATACTGAAGGAAGGGCTCCCTCGAGTTCTGGTGTGAAG
AGATAAATCACCAGTCACAGACTATGCACCCGACTGCTGCTGTTCAGTCCAGGGAAAATGAAAGTTGGAGTGCTGTGGCTCATTTCTTTC
TTCACCTTCACTGACGGCCACGGTGGCTTCCTGGGGAAAAATGATGGCATCAAAACAAAAAAAGAACTCATTGTGAATAAGAAAAAACAT
CTAGGCCCAGTCGAAGAATATCAGCTGCTGCTTCAGGTGACCTATAGAGATTCCAAGGAGAAAAGAGATTTGAGAAATTTTCTGAAGCTC
TTGAAGCCTCCATTATTATGGTCACATGGGCTAATTAGAATTATCAGAGCAAAGGCTACCACAGACTGCAACAGCCTGAATGGAGTCCTG
CAGTGTACCTGTGAAGACAGCTACACCTGGTTTCCTCCCTCATGCCTTGATCCCCAGAACTGCTACCTTCACACGGCTGGAGCACTCCCA
AGCTGTGAATGTCATCTCAACAACCTCAGCCAGAGTGTCAATTTCTGTGAGAGAACAAAGATTTGGGGCACTTTCAAAATTAATGAAAGG
TTTACAAATGACCTTTTGAATTCATCTTCTGCTATATACTCCAAATATGCAAATGGAATTGAAATTCAACTTGGATTCCTTAGCACCACC
ACAGCTCAGCCAGAACAGAAGGCCTCGAATCTCATTGGCACATACCGCCATGTTGACCGTGCCACCGGCCAGGTGCTAACCTGTGACAAG
TGTCCAGCAGGAACCTATGTCTCTGAGCATTGTACCAACACAAGCCTGCGCGTCTGCAGCAGTTGCCCTGTGGGGACCTTTACCAGGCAT
GAGAATGGCATAGAGAAATGCCATGACTGTAGTCAGCCATGCCCATGGCCAATGATTGAGAAATTACCTTGTGCTGCCTTGACTGACCGA
GAATGCACTTGCCCACCTGGCATGTTCCAGTCTAACGCTACCTGTGCCCCCCATACGGTGTGTCCTGTGGGTTGGGGTGTGCGGAAGAAA
GGGACAGAGACTGAGGATGTGCGGTGTAAGCAGTGTGCTCGGGGTACCTTCTCAGATGTGCCTTCTAGTGTGATGAAATGCAAAGCATAC
ACAGACTGTCTGAGTCAGAACCTGGTGGTGATCAAGCCGGGGACCAAGGAGACAGACAACGTCTGTGGCACACTCCCGTCCTTCTCCAGC
TCCACCTCACCTTCCCCTGGCACAGCCATCTTTCCACGCCCTGAGCACATGGAAACCCATGAAGTCCCTTCCTCCACTTATGTTCCCAAA
GGCATGAACTCAACAGAATCCAACTCTTCTGCCTCTGTTAGACCAAAGGTACTGAGTAGCATCCAGGAAGGGACAGTCCCTGACAACACA
AGCTCAGCAAGGGGGAAGGAAGACGTGAACAAGACCCTCCCAAACCTTCAGGTAGTCAACCACCAGCAAGGCCCCCACCACAGACACATC
CTGAAGCTGCTGCCGTCCATGGAGGCCACTGGGGGCGAGAAGTCCAGCACGCCCATCAAGGGCCCCAAGAGGGGACATCCTAGACAGAAC
CTACACAAGCATTTTGACATCAATGAGCATTTGCCCTGGATGATTGTGCTTTTCCTGCTGCTGGTGCTTGTGGTGATTGTGGTGTGCAGT
ATCCGGAAAAGCTCGAGGACTCTGAAAAAGGGGCCCCGGCAGGATCCCAGTGCCATTGTGGAAAAGGCAGGGCTGAAGAAATCCATGACT
CCAACCCAGAACCGGGAGAAATGGATCTACTACTGCAATGGCCATGGTATCGATATCCTGAAGCTTGTAGCAGCCCAAGTGGGAAGCCAG
TGGAAAGATATCTATCAGTTTCTTTGCAATGCCAGTGAGAGGGAGGTTGCTGCTTTCTCCAATGGGTACACAGCCGACCACGAGCGGGCC
TACGCAGCTCTGCAGCACTGGACCATCCGGGGCCCCGAGGCCAGCCTCGCCCAGCTAATTAGCGCCCTGCGCCAGCACCGGAGAAACGAT
GTTGTGGAGAAGATTCGTGGGCTGATGGAAGACACCACCCAGCTGGAAACTGACAAACTAGCTCTCCCGATGAGCCCCAGCCCGCTTAGC
CCGAGCCCCATCCCCAGCCCCAACGCGAAACTTGAGAATTCCGCTCTCCTGACGGTGGAGCCTTCCCCACAGGACAAGAACAAGGGCTTC
TTCGTGGATGAGTCGGAGCCCCTTCTCCGCTGTGACTCTACATCCAGCGGCTCCTCCGCGCTGAGCAGGAACGGTTCCTTTATTACCAAA
GAAAAGAAGGACACAGTGTTGCGGCAGGTACGCCTGGACCCCTGTGACTTGCAGCCTATCTTTGATGACATGCTCCACTTTCTAAATCCT
GAGGAGCTGCGGGTGATTGAAGAGATTCCCCAGGCTGAGGACAAACTAGACCGGCTATTCGAAATTATTGGAGTCAAGAGCCAGGAAGCC
AGCCAGACCCTCCTGGACTCTGTTTATAGCCATCTTCCTGACCTGCTGTAGAACATAGGGATACTGCATTCTGGAAATTACTCAATTTAG
TGGCAGGGTGGTTTTTTAATTTTCTTCTGTTTCTGATTTTTGTTGTTTGGGGTGTGTGTGTGTGTTTGTGTGTGTGTGTGTGTGTGTGTG
TGTGTGTGTGTTTAACAGAGAATATGGCCAGTGCTTGAGTTCTTTCTCCTTCTCTCTCTCTCTTTTTTTTTTAAATAACTCTTCTGGGAA
GTTGGTTTATAAGCCTTTGCCAGGTGTAACTGTTGTGAAATACCCACCACTAAAGTTTTTTAAGTTCCATATTTTCTCCATTTTGCCTTC
TTATGTATTTTCAAGATTATTCTGTGCACTTTAAATTTACTTAACTTACCATAAATGCAGTGTGACTTTTCCCACACACTGGATTGTGAG
GCTCTTAACTTCTTAAAAGTATAATGGCATCTTGTGAATCCTATAAGCAGTCTTTATGTCTCTTAACATTCACACCTACTTTTTAAAAAC
AAATATTATTACTATTTTTATTATTGTTTGTCCTTTATAAATTTTCTTAAAGATTAAGAAAATTTAAGACCCCATTGAGTTACTGTAATG
CAATTCAACTTTGAGTTATCTTTTAAATATGTCTTGTATAGTTCATATTCATGGCTGAAACTTGACCACACTATTGCTGATTGTATGGTT
TTCACCTGGACACCGTGTAGAATGCTTGATTACTTGTACTCTTCTTATGCTAATATGCTCTGGGCTGGAGAAATGAAATCCTCAAGCCAT
CAGGATTTGCTATTTAAGTGGCTTGACAACTGGGCCACCAAAGAACTTGAACTTCACCTTTTAGGATTTGAGCTGTTCTGGAACACATTG
CTGCACTTTGGAAAGTCAAAATCAAGTGCCAGTGGCGCCCTTTCCATAGAGAATTTGCCCAGCTTTGCTTTAAAAGATGTCTTGTTTTTT
ATATACACATAATCAATAGGTCCAATCTGCTCTCAAGGCCTTGGTCCTGGTGGGATTCCTTCACCAATTACTTTAATTAAAAATGGCTGC
AACTGTAAGAACCCTTGTCTGATATATTTGCAACTATGCTCCCATTTACAAATGTACCTTCTAATGCTCAGTTGCCAGGTTCCAATGCAA
AGGTGGCGTGGACTCCCTTTGTGTGGGTGGGGTTTGTGGGTAGTGGTGAAGGACCGATATCAGAAAAATGCCTTCAAGTGTACTAATTTA

>In-frame_ENST00000371243_ENST00000296861_TCGA-DK-AA6S_GPR110_chr6_46989694_-_TNFRSF21_chr6_47254331_length(amino acids)=815AA_start in transcript=123_stop in transcript=2570
MLLFSPGKMKVGVLWLISFFTFTDGHGGFLGKNDGIKTKKELIVNKKKHLGPVEEYQLLLQVTYRDSKEKRDLRNFLKLLKPPLLWSHGL
IRIIRAKATTDCNSLNGVLQCTCEDSYTWFPPSCLDPQNCYLHTAGALPSCECHLNNLSQSVNFCERTKIWGTFKINERFTNDLLNSSSA
IYSKYANGIEIQLGFLSTTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENGIEKCHDCS
QPCPWPMIEKLPCAALTDRECTCPPGMFQSNATCAPHTVCPVGWGVRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVI
KPGTKETDNVCGTLPSFSSSTSPSPGTAIFPRPEHMETHEVPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVPDNTSSARGKEDVNK
TLPNLQVVNHQQGPHHRHILKLLPSMEATGGEKSSTPIKGPKRGHPRQNLHKHFDINEHLPWMIVLFLLLVLVVIVVCSIRKSSRTLKKG
PRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRG
PEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDKLALPMSPSPLSPSPIPSPNAKLENSALLTVEPSPQDKNKGFFVDESEPLLRC
DSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHFLNPEELRVIEEIPQAEDKLDRLFEIIGVKSQEASQTLLDSVYSH

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Fusion Gene PPI Analysis for GPR110-TNFRSF21


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GPR110-TNFRSF21


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GPR110-TNFRSF21


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTNFRSF21C0002736Amyotrophic Lateral Sclerosis1CTD_human
TgeneTNFRSF21C0017639Gliosis1CTD_human
TgeneTNFRSF21C0033578Prostatic Neoplasms1CTD_human
TgeneTNFRSF21C0376358Malignant neoplasm of prostate1CTD_human
TgeneTNFRSF21C0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
TgeneTNFRSF21C0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
TgeneTNFRSF21C3887640Astrocytosis1CTD_human