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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GPR137B-TBCE (FusionGDB2 ID:34255)

Fusion Gene Summary for GPR137B-TBCE

Fusion gene summary

Fusion gene information	Fusion gene name: GPR137B-TBCE
	Fusion gene ID: 34255
		Hgene	Tgene
	Gene symbol	GPR137B	TBCE
	Gene ID	7107	6905
	Gene name	G protein-coupled receptor 137B	tubulin folding cofactor E
	Synonyms	TM7SF1	HRD\|KCS\|KCS1\|PEAMO\|pac2
	Cytomap	1q42.3	1q42.3
	Type of gene	protein-coding	protein-coding
	Description	integral membrane protein GPR137Btransmembrane 7 superfamily member 1 (upregulated in kidney)transmembrane 7 superfamily member 1 protein	tubulin-specific chaperone Ehypoparathyroidism, growth and mental retardation, and dysmorphism
	Modification date	20200313	20200313
	UniProtAcc	O60478	Q5QJ74
	Ensembl transtripts involved in fusion gene	ENST00000366592, ENST00000366591, ENST00000477559,	ENST00000366601, ENST00000406207, ENST00000543662, ENST00000472011,
Fusion gene scores	* DoF score	5 X 6 X 4=120	6 X 7 X 4=168
	# samples	5	7
	** MAII score	log2(5/120*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GPR137B [Title/Abstract] AND TBCE [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GPR137B(236306336)-TBCE(235597519), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TBCE	GO:0007023	post-chaperonin tubulin folding pathway	11847227

Fusion gene breakpoints across GPR137B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TBCE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-BG-A0MH-01A	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+

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Fusion Gene ORF analysis for GPR137B-TBCE

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000366592	ENST00000366601	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+
In-frame	ENST00000366592	ENST00000406207	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+
In-frame	ENST00000366592	ENST00000543662	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+
5CDS-3UTR	ENST00000366592	ENST00000472011	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+
In-frame	ENST00000366591	ENST00000366601	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+
In-frame	ENST00000366591	ENST00000406207	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+
In-frame	ENST00000366591	ENST00000543662	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+
5CDS-3UTR	ENST00000366591	ENST00000472011	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+
intron-3CDS	ENST00000477559	ENST00000366601	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+
intron-3CDS	ENST00000477559	ENST00000406207	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+
intron-3CDS	ENST00000477559	ENST00000543662	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+
intron-3UTR	ENST00000477559	ENST00000472011	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000366592	GPR137B	chr1	236306336	+	ENST00000366601	TBCE	chr1	235597519	+	1635	505	91	1428	445
ENST00000366592	GPR137B	chr1	236306336	+	ENST00000406207	TBCE	chr1	235597519	+	1630	505	91	1428	445
ENST00000366592	GPR137B	chr1	236306336	+	ENST00000543662	TBCE	chr1	235597519	+	1566	505	91	1428	445
ENST00000366591	GPR137B	chr1	236306336	+	ENST00000366601	TBCE	chr1	235597519	+	1623	493	79	1416	445
ENST00000366591	GPR137B	chr1	236306336	+	ENST00000406207	TBCE	chr1	235597519	+	1618	493	79	1416	445
ENST00000366591	GPR137B	chr1	236306336	+	ENST00000543662	TBCE	chr1	235597519	+	1554	493	79	1416	445

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000366592	ENST00000366601	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+	0.00419632	0.99580365
ENST00000366592	ENST00000406207	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+	0.004289059	0.99571097
ENST00000366592	ENST00000543662	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+	0.005066198	0.9949338
ENST00000366591	ENST00000366601	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+	0.004358857	0.9956411
ENST00000366591	ENST00000406207	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+	0.004476829	0.9955232
ENST00000366591	ENST00000543662	GPR137B	chr1	236306336	+	TBCE	chr1	235597519	+	0.005294409	0.9947056

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Fusion Genomic Features for GPR137B-TBCE

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GPR137B	chr1	236306336	+	TBCE	chr1	235597518	+	0.002369992	0.99763
GPR137B	chr1	236306336	+	TBCE	chr1	235597518	+	0.002369992	0.99763

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GPR137B-TBCE

Go to
FGviewer for the breakpoints of chr1:236306336-chr1:235597519
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GPR137B O60478	TBCE Q5QJ74
FUNCTION: Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939). {ECO:0000269\|PubMed:31036939}.; FUNCTION: Acts also as a negative regulator of osteoclast activity (By similarity). Involved in interleukin-4-induced M2 macrophage polarization (By similarity). {ECO:0000250\|UniProtKB:Q8BNQ3}.	FUNCTION: Acts as a regulator of tubulin stability. {ECO:0000269\|PubMed:15728251}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GPR137B

chr1:236306336

chr1:235597519

ENST00000366592

101_111

138.0

400.0

Topological domain

Lumenal

Hgene

GPR137B

chr1:236306336

chr1:235597519

ENST00000366592

1_46

138.0

400.0

Topological domain

Lumenal

Hgene

GPR137B

chr1:236306336

chr1:235597519

ENST00000366592

68_79

138.0

400.0

Topological domain

Cytoplasmic

Hgene

GPR137B

chr1:236306336

chr1:235597519

ENST00000366592

112_132

138.0

400.0

Transmembrane

Helical%3B Name%3D3

Hgene

GPR137B

chr1:236306336

chr1:235597519

ENST00000366592

47_67

138.0

400.0

Transmembrane

Helical%3B Name%3D1

Hgene

GPR137B

chr1:236306336

chr1:235597519

ENST00000366592

80_100

138.0

400.0

Transmembrane

Helical%3B Name%3D2

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000366601

342_384

220.0

528.0

Domain

Note=LRRCT

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000406207

342_384

220.0

528.0

Domain

Note=LRRCT

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000366601

230_252

220.0

528.0

Repeat

Note=LRR 4

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000366601

253_274

220.0

528.0

Repeat

Note=LRR 5

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000366601

278_299

220.0

528.0

Repeat

Note=LRR 6

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000366601

308_329

220.0

528.0

Repeat

Note=LRR 7

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000406207

230_252

220.0

528.0

Repeat

Note=LRR 4

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000406207

253_274

220.0

528.0

Repeat

Note=LRR 5

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000406207

278_299

220.0

528.0

Repeat

Note=LRR 6

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000406207

308_329

220.0

528.0

Repeat

Note=LRR 7

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GPR137B

chr1:236306336

chr1:235597519

ENST00000366592

133_159

138.0

400.0

Topological domain

Cytoplasmic

Hgene

GPR137B

chr1:236306336

chr1:235597519

ENST00000366592

181_188

138.0

400.0

Topological domain

Lumenal

Hgene

GPR137B

chr1:236306336

chr1:235597519

ENST00000366592

210_237

138.0

400.0

Topological domain

Cytoplasmic

Hgene

GPR137B

chr1:236306336

chr1:235597519

ENST00000366592

259_292

138.0

400.0

Topological domain

Lumenal

Hgene

GPR137B

chr1:236306336

chr1:235597519

ENST00000366592

314_399

138.0

400.0

Topological domain

Cytoplasmic

Hgene

GPR137B

chr1:236306336

chr1:235597519

ENST00000366592

160_180

138.0

400.0

Transmembrane

Helical%3B Name%3D4

Hgene

GPR137B

chr1:236306336

chr1:235597519

ENST00000366592

189_209

138.0

400.0

Transmembrane

Helical%3B Name%3D5

Hgene

GPR137B

chr1:236306336

chr1:235597519

ENST00000366592

238_258

138.0

400.0

Transmembrane

Helical%3B Name%3D6

Hgene

GPR137B

chr1:236306336

chr1:235597519

ENST00000366592

293_313

138.0

400.0

Transmembrane

Helical%3B Name%3D7

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000366601

27_71

220.0

528.0

Domain

CAP-Gly

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000406207

27_71

220.0

528.0

Domain

CAP-Gly

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000366601

154_175

220.0

528.0

Repeat

Note=LRR 1

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000366601

180_200

220.0

528.0

Repeat

Note=LRR 2

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000366601

205_226

220.0

528.0

Repeat

Note=LRR 3

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000406207

154_175

220.0

528.0

Repeat

Note=LRR 1

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000406207

180_200

220.0

528.0

Repeat

Note=LRR 2

Tgene

TBCE

chr1:236306336

chr1:235597519

ENST00000406207

205_226

220.0

528.0

Repeat

Note=LRR 3

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Fusion Gene Sequence for GPR137B-TBCE

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000366592_ENST00000366601_TCGA-BG-A0MH-01A_GPR137B_chr1_236306336_+_TBCE_chr1_235597519_length(transcript)=1635nt_BP=505nt
GCGGCTTGTTTTCTTTCCTCCAGTCTCGGGGCTGCAGGCTGAGCGCGATGCGCGGAGACCCCCGCGGGGGCGGCGGCGGCCGTGAGCCCC
GATGAGGCCCGAGCGTCCCCGGCCGCGCGGCAGCGCCCCCGGCCCGATGGAGACCCCGCCGTGGGACCCAGCCCGCAACGACTCGCTGCC
GCCCACGCTGACCCCGGCCGTGCCCCCCTACGTGAAGCTTGGCCTCACCGTCGTCTACACCGTGTTCTACGCGCTGCTCTTCGTGTTCAT
CTACGTGCAGCTCTGGCTGGTGCTGCGTTACCGCCACAAGCGGCTCAGCTACCAGAGCGTCTTCCTCTTTCTCTGCCTCTTCTGGGCCTC
CCTGCGGACCGTCCTCTTCTCCTTCTACTTCAAAGACTTCGTGGCGGCCAATTCGCTCAGCCCCTTCGTCTTCTGGCTGCTCTACTGCTT
CCCTGTGTGCCTGCAGTTTTTCACCCTCACGCTGATGAACTTGTACTTCACGCAGGTGCTGCGGTGTGTCGCGGGGTGCCCAGGCCTGGA
GGAACTCTACCTTGAGTCTAACAACATTTTCATTTCCGAAAGGCCAACAGATGTTCTCCAGACAGTCAAGTTATTAGATCTTTCCTCTAA
TCAATTAATTGATGAAAATCAGCTGTATCTGATAGCCCACCTGCCCAGGTTAGAACAATTAATCCTCTCTGACACTGGAATTTCTTCTCT
ACATTTTCCGGATGCTGGAATTGGGTGCAAAACGTCCATGTTCCCATCCTTGAAGTACCTGGTAGTAAACGACAATCAGATATCACAATG
GTCGTTTTTCAATGAGCTAGAGAAGTTACCAAGTCTACGGGCTTTGTCCTGCCTAAGAAACCCCCTGACCAAAGAGGACAAAGAAGCAGA
GACGGCGCGACTACTCATTATCGCCAGCATTGGCCAGCTGAAGACGCTGAACAAATGTGAGATTCTCCCCGAGGAGAGGCGGAGAGCTGA
GCTTGACTACCGAAAAGCTTTTGGAAATGAGTGGAAACAGGCTGGTGGACATAAGGATCCGGAAAAAAACAGACTCAGCGAAGAATTCCT
CACAGCCCATCCCAGATACCAGTTCCTCTGCCTGAAATATGGTGCACCTGAAGATTGGGAACTCAAAACACAGCAACCACTTATGCTGAA
AAACCAGCTACTAACACTGAAGATAAAATACCCTCATCAACTTGATCAGAAAGTCCTGGAGAAACAACTGCCGGGCTCCATGACAATTCA
AAAGGTGAAGGGATTGCTGTCACGTCTTCTCAAAGTTCCTGTGTCAGACCTTCTGTTGTCCTATGAAAGTCCCAAAAAGCCGGGCAGAGA
AATCGAGCTGGAAAATGACCTAAAGTCATTACAGTTTTATTCTGTGGAAAATGGAGATTGTCTATTAGTGCGATGGTGACAACCAACTAA
TAAAATTTAAAGACCACACTGCTTATCGTGTCTGGGGTTCACCGGAAATAAATGATTCACTGGAACAATTCTACTGTCAAAACAAAGGGG
GTTTACAACTTGTCCTAAGTATAACAAGGGATGTATTTTTTGTTGGGAAGTGACCATTTCTAGGCTTATACATAATAGCAATAATAAAGG

>In-frame_ENST00000366592_ENST00000366601_TCGA-BG-A0MH-01A_GPR137B_chr1_236306336_+_TBCE_chr1_235597519_length(amino acids)=445AA_start in transcript=91_stop in transcript=1428
MRPERPRPRGSAPGPMETPPWDPARNDSLPPTLTPAVPPYVKLGLTVVYTVFYALLFVFIYVQLWLVLRYRHKRLSYQSVFLFLCLFWAS
LRTVLFSFYFKDFVAANSLSPFVFWLLYCFPVCLQFFTLTLMNLYFTQVLRCVAGCPGLEELYLESNNIFISERPTDVLQTVKLLDLSSN
QLIDENQLYLIAHLPRLEQLILSDTGISSLHFPDAGIGCKTSMFPSLKYLVVNDNQISQWSFFNELEKLPSLRALSCLRNPLTKEDKEAE
TARLLIIASIGQLKTLNKCEILPEERRRAELDYRKAFGNEWKQAGGHKDPEKNRLSEEFLTAHPRYQFLCLKYGAPEDWELKTQQPLMLK

--------------------------------------------------------------
>In-frame_ENST00000366592_ENST00000406207_TCGA-BG-A0MH-01A_GPR137B_chr1_236306336_+_TBCE_chr1_235597519_length(transcript)=1630nt_BP=505nt
GCGGCTTGTTTTCTTTCCTCCAGTCTCGGGGCTGCAGGCTGAGCGCGATGCGCGGAGACCCCCGCGGGGGCGGCGGCGGCCGTGAGCCCC
GATGAGGCCCGAGCGTCCCCGGCCGCGCGGCAGCGCCCCCGGCCCGATGGAGACCCCGCCGTGGGACCCAGCCCGCAACGACTCGCTGCC
GCCCACGCTGACCCCGGCCGTGCCCCCCTACGTGAAGCTTGGCCTCACCGTCGTCTACACCGTGTTCTACGCGCTGCTCTTCGTGTTCAT
CTACGTGCAGCTCTGGCTGGTGCTGCGTTACCGCCACAAGCGGCTCAGCTACCAGAGCGTCTTCCTCTTTCTCTGCCTCTTCTGGGCCTC
CCTGCGGACCGTCCTCTTCTCCTTCTACTTCAAAGACTTCGTGGCGGCCAATTCGCTCAGCCCCTTCGTCTTCTGGCTGCTCTACTGCTT
CCCTGTGTGCCTGCAGTTTTTCACCCTCACGCTGATGAACTTGTACTTCACGCAGGTGCTGCGGTGTGTCGCGGGGTGCCCAGGCCTGGA
GGAACTCTACCTTGAGTCTAACAACATTTTCATTTCCGAAAGGCCAACAGATGTTCTCCAGACAGTCAAGTTATTAGATCTTTCCTCTAA
TCAATTAATTGATGAAAATCAGCTGTATCTGATAGCCCACCTGCCCAGGTTAGAACAATTAATCCTCTCTGACACTGGAATTTCTTCTCT
ACATTTTCCGGATGCTGGAATTGGGTGCAAAACGTCCATGTTCCCATCCTTGAAGTACCTGGTAGTAAACGACAATCAGATATCACAATG
GTCGTTTTTCAATGAGCTAGAGAAGTTACCAAGTCTACGGGCTTTGTCCTGCCTAAGAAACCCCCTGACCAAAGAGGACAAAGAAGCAGA
GACGGCGCGACTACTCATTATCGCCAGCATTGGCCAGCTGAAGACGCTGAACAAATGTGAGATTCTCCCCGAGGAGAGGCGGAGAGCTGA
GCTTGACTACCGAAAAGCTTTTGGAAATGAGTGGAAACAGGCTGGTGGACATAAGGATCCGGAAAAAAACAGACTCAGCGAAGAATTCCT
CACAGCCCATCCCAGATACCAGTTCCTCTGCCTGAAATATGGTGCACCTGAAGATTGGGAACTCAAAACACAGCAACCACTTATGCTGAA
AAACCAGCTACTAACACTGAAGATAAAATACCCTCATCAACTTGATCAGAAAGTCCTGGAGAAACAACTGCCGGGCTCCATGACAATTCA
AAAGGTGAAGGGATTGCTGTCACGTCTTCTCAAAGTTCCTGTGTCAGACCTTCTGTTGTCCTATGAAAGTCCCAAAAAGCCGGGCAGAGA
AATCGAGCTGGAAAATGACCTAAAGTCATTACAGTTTTATTCTGTGGAAAATGGAGATTGTCTATTAGTGCGATGGTGACAACCAACTAA
TAAAATTTAAAGACCACACTGCTTATCGTGTCTGGGGTTCACCGGAAATAAATGATTCACTGGAACAATTCTACTGTCAAAACAAAGGGG
GTTTACAACTTGTCCTAAGTATAACAAGGGATGTATTTTTTGTTGGGAAGTGACCATTTCTAGGCTTATACATAATAGCAATAATAAAGG

>In-frame_ENST00000366592_ENST00000406207_TCGA-BG-A0MH-01A_GPR137B_chr1_236306336_+_TBCE_chr1_235597519_length(amino acids)=445AA_start in transcript=91_stop in transcript=1428
MRPERPRPRGSAPGPMETPPWDPARNDSLPPTLTPAVPPYVKLGLTVVYTVFYALLFVFIYVQLWLVLRYRHKRLSYQSVFLFLCLFWAS
LRTVLFSFYFKDFVAANSLSPFVFWLLYCFPVCLQFFTLTLMNLYFTQVLRCVAGCPGLEELYLESNNIFISERPTDVLQTVKLLDLSSN
QLIDENQLYLIAHLPRLEQLILSDTGISSLHFPDAGIGCKTSMFPSLKYLVVNDNQISQWSFFNELEKLPSLRALSCLRNPLTKEDKEAE
TARLLIIASIGQLKTLNKCEILPEERRRAELDYRKAFGNEWKQAGGHKDPEKNRLSEEFLTAHPRYQFLCLKYGAPEDWELKTQQPLMLK

--------------------------------------------------------------
>In-frame_ENST00000366592_ENST00000543662_TCGA-BG-A0MH-01A_GPR137B_chr1_236306336_+_TBCE_chr1_235597519_length(transcript)=1566nt_BP=505nt
GCGGCTTGTTTTCTTTCCTCCAGTCTCGGGGCTGCAGGCTGAGCGCGATGCGCGGAGACCCCCGCGGGGGCGGCGGCGGCCGTGAGCCCC
GATGAGGCCCGAGCGTCCCCGGCCGCGCGGCAGCGCCCCCGGCCCGATGGAGACCCCGCCGTGGGACCCAGCCCGCAACGACTCGCTGCC
GCCCACGCTGACCCCGGCCGTGCCCCCCTACGTGAAGCTTGGCCTCACCGTCGTCTACACCGTGTTCTACGCGCTGCTCTTCGTGTTCAT
CTACGTGCAGCTCTGGCTGGTGCTGCGTTACCGCCACAAGCGGCTCAGCTACCAGAGCGTCTTCCTCTTTCTCTGCCTCTTCTGGGCCTC
CCTGCGGACCGTCCTCTTCTCCTTCTACTTCAAAGACTTCGTGGCGGCCAATTCGCTCAGCCCCTTCGTCTTCTGGCTGCTCTACTGCTT
CCCTGTGTGCCTGCAGTTTTTCACCCTCACGCTGATGAACTTGTACTTCACGCAGGTGCTGCGGTGTGTCGCGGGGTGCCCAGGCCTGGA
GGAACTCTACCTTGAGTCTAACAACATTTTCATTTCCGAAAGGCCAACAGATGTTCTCCAGACAGTCAAGTTATTAGATCTTTCCTCTAA
TCAATTAATTGATGAAAATCAGCTGTATCTGATAGCCCACCTGCCCAGGTTAGAACAATTAATCCTCTCTGACACTGGAATTTCTTCTCT
ACATTTTCCGGATGCTGGAATTGGGTGCAAAACGTCCATGTTCCCATCCTTGAAGTACCTGGTAGTAAACGACAATCAGATATCACAATG
GTCGTTTTTCAATGAGCTAGAGAAGTTACCAAGTCTACGGGCTTTGTCCTGCCTAAGAAACCCCCTGACCAAAGAGGACAAAGAAGCAGA
GACGGCGCGACTACTCATTATCGCCAGCATTGGCCAGCTGAAGACGCTGAACAAATGTGAGATTCTCCCCGAGGAGAGGCGGAGAGCTGA
GCTTGACTACCGAAAAGCTTTTGGAAATGAGTGGAAACAGGCTGGTGGACATAAGGATCCGGAAAAAAACAGACTCAGCGAAGAATTCCT
CACAGCCCATCCCAGATACCAGTTCCTCTGCCTGAAATATGGTGCACCTGAAGATTGGGAACTCAAAACACAGCAACCACTTATGCTGAA
AAACCAGCTACTAACACTGAAGATAAAATACCCTCATCAACTTGATCAGAAAGTCCTGGAGAAACAACTGCCGGGCTCCATGACAATTCA
AAAGGTGAAGGGATTGCTGTCACGTCTTCTCAAAGTTCCTGTGTCAGACCTTCTGTTGTCCTATGAAAGTCCCAAAAAGCCGGGCAGAGA
AATCGAGCTGGAAAATGACCTAAAGTCATTACAGTTTTATTCTGTGGAAAATGGAGATTGTCTATTAGTGCGATGGTGACAACCAACTAA
TAAAATTTAAAGACCACACTGCTTATCGTGTCTGGGGTTCACCGGAAATAAATGATTCACTGGAACAATTCTACTGTCAAAACAAAGGGG

>In-frame_ENST00000366592_ENST00000543662_TCGA-BG-A0MH-01A_GPR137B_chr1_236306336_+_TBCE_chr1_235597519_length(amino acids)=445AA_start in transcript=91_stop in transcript=1428
MRPERPRPRGSAPGPMETPPWDPARNDSLPPTLTPAVPPYVKLGLTVVYTVFYALLFVFIYVQLWLVLRYRHKRLSYQSVFLFLCLFWAS
LRTVLFSFYFKDFVAANSLSPFVFWLLYCFPVCLQFFTLTLMNLYFTQVLRCVAGCPGLEELYLESNNIFISERPTDVLQTVKLLDLSSN
QLIDENQLYLIAHLPRLEQLILSDTGISSLHFPDAGIGCKTSMFPSLKYLVVNDNQISQWSFFNELEKLPSLRALSCLRNPLTKEDKEAE
TARLLIIASIGQLKTLNKCEILPEERRRAELDYRKAFGNEWKQAGGHKDPEKNRLSEEFLTAHPRYQFLCLKYGAPEDWELKTQQPLMLK

--------------------------------------------------------------
>In-frame_ENST00000366591_ENST00000366601_TCGA-BG-A0MH-01A_GPR137B_chr1_236306336_+_TBCE_chr1_235597519_length(transcript)=1623nt_BP=493nt
CTTTCCTCCAGTCTCGGGGCTGCAGGCTGAGCGCGATGCGCGGAGACCCCCGCGGGGGCGGCGGCGGCCGTGAGCCCCGATGAGGCCCGA
GCGTCCCCGGCCGCGCGGCAGCGCCCCCGGCCCGATGGAGACCCCGCCGTGGGACCCAGCCCGCAACGACTCGCTGCCGCCCACGCTGAC
CCCGGCCGTGCCCCCCTACGTGAAGCTTGGCCTCACCGTCGTCTACACCGTGTTCTACGCGCTGCTCTTCGTGTTCATCTACGTGCAGCT
CTGGCTGGTGCTGCGTTACCGCCACAAGCGGCTCAGCTACCAGAGCGTCTTCCTCTTTCTCTGCCTCTTCTGGGCCTCCCTGCGGACCGT
CCTCTTCTCCTTCTACTTCAAAGACTTCGTGGCGGCCAATTCGCTCAGCCCCTTCGTCTTCTGGCTGCTCTACTGCTTCCCTGTGTGCCT
GCAGTTTTTCACCCTCACGCTGATGAACTTGTACTTCACGCAGGTGCTGCGGTGTGTCGCGGGGTGCCCAGGCCTGGAGGAACTCTACCT
TGAGTCTAACAACATTTTCATTTCCGAAAGGCCAACAGATGTTCTCCAGACAGTCAAGTTATTAGATCTTTCCTCTAATCAATTAATTGA
TGAAAATCAGCTGTATCTGATAGCCCACCTGCCCAGGTTAGAACAATTAATCCTCTCTGACACTGGAATTTCTTCTCTACATTTTCCGGA
TGCTGGAATTGGGTGCAAAACGTCCATGTTCCCATCCTTGAAGTACCTGGTAGTAAACGACAATCAGATATCACAATGGTCGTTTTTCAA
TGAGCTAGAGAAGTTACCAAGTCTACGGGCTTTGTCCTGCCTAAGAAACCCCCTGACCAAAGAGGACAAAGAAGCAGAGACGGCGCGACT
ACTCATTATCGCCAGCATTGGCCAGCTGAAGACGCTGAACAAATGTGAGATTCTCCCCGAGGAGAGGCGGAGAGCTGAGCTTGACTACCG
AAAAGCTTTTGGAAATGAGTGGAAACAGGCTGGTGGACATAAGGATCCGGAAAAAAACAGACTCAGCGAAGAATTCCTCACAGCCCATCC
CAGATACCAGTTCCTCTGCCTGAAATATGGTGCACCTGAAGATTGGGAACTCAAAACACAGCAACCACTTATGCTGAAAAACCAGCTACT
AACACTGAAGATAAAATACCCTCATCAACTTGATCAGAAAGTCCTGGAGAAACAACTGCCGGGCTCCATGACAATTCAAAAGGTGAAGGG
ATTGCTGTCACGTCTTCTCAAAGTTCCTGTGTCAGACCTTCTGTTGTCCTATGAAAGTCCCAAAAAGCCGGGCAGAGAAATCGAGCTGGA
AAATGACCTAAAGTCATTACAGTTTTATTCTGTGGAAAATGGAGATTGTCTATTAGTGCGATGGTGACAACCAACTAATAAAATTTAAAG
ACCACACTGCTTATCGTGTCTGGGGTTCACCGGAAATAAATGATTCACTGGAACAATTCTACTGTCAAAACAAAGGGGGTTTACAACTTG
TCCTAAGTATAACAAGGGATGTATTTTTTGTTGGGAAGTGACCATTTCTAGGCTTATACATAATAGCAATAATAAAGGCTTTGAACCTAC

>In-frame_ENST00000366591_ENST00000366601_TCGA-BG-A0MH-01A_GPR137B_chr1_236306336_+_TBCE_chr1_235597519_length(amino acids)=445AA_start in transcript=79_stop in transcript=1416
MRPERPRPRGSAPGPMETPPWDPARNDSLPPTLTPAVPPYVKLGLTVVYTVFYALLFVFIYVQLWLVLRYRHKRLSYQSVFLFLCLFWAS
LRTVLFSFYFKDFVAANSLSPFVFWLLYCFPVCLQFFTLTLMNLYFTQVLRCVAGCPGLEELYLESNNIFISERPTDVLQTVKLLDLSSN
QLIDENQLYLIAHLPRLEQLILSDTGISSLHFPDAGIGCKTSMFPSLKYLVVNDNQISQWSFFNELEKLPSLRALSCLRNPLTKEDKEAE
TARLLIIASIGQLKTLNKCEILPEERRRAELDYRKAFGNEWKQAGGHKDPEKNRLSEEFLTAHPRYQFLCLKYGAPEDWELKTQQPLMLK

--------------------------------------------------------------
>In-frame_ENST00000366591_ENST00000406207_TCGA-BG-A0MH-01A_GPR137B_chr1_236306336_+_TBCE_chr1_235597519_length(transcript)=1618nt_BP=493nt
CTTTCCTCCAGTCTCGGGGCTGCAGGCTGAGCGCGATGCGCGGAGACCCCCGCGGGGGCGGCGGCGGCCGTGAGCCCCGATGAGGCCCGA
GCGTCCCCGGCCGCGCGGCAGCGCCCCCGGCCCGATGGAGACCCCGCCGTGGGACCCAGCCCGCAACGACTCGCTGCCGCCCACGCTGAC
CCCGGCCGTGCCCCCCTACGTGAAGCTTGGCCTCACCGTCGTCTACACCGTGTTCTACGCGCTGCTCTTCGTGTTCATCTACGTGCAGCT
CTGGCTGGTGCTGCGTTACCGCCACAAGCGGCTCAGCTACCAGAGCGTCTTCCTCTTTCTCTGCCTCTTCTGGGCCTCCCTGCGGACCGT
CCTCTTCTCCTTCTACTTCAAAGACTTCGTGGCGGCCAATTCGCTCAGCCCCTTCGTCTTCTGGCTGCTCTACTGCTTCCCTGTGTGCCT
GCAGTTTTTCACCCTCACGCTGATGAACTTGTACTTCACGCAGGTGCTGCGGTGTGTCGCGGGGTGCCCAGGCCTGGAGGAACTCTACCT
TGAGTCTAACAACATTTTCATTTCCGAAAGGCCAACAGATGTTCTCCAGACAGTCAAGTTATTAGATCTTTCCTCTAATCAATTAATTGA
TGAAAATCAGCTGTATCTGATAGCCCACCTGCCCAGGTTAGAACAATTAATCCTCTCTGACACTGGAATTTCTTCTCTACATTTTCCGGA
TGCTGGAATTGGGTGCAAAACGTCCATGTTCCCATCCTTGAAGTACCTGGTAGTAAACGACAATCAGATATCACAATGGTCGTTTTTCAA
TGAGCTAGAGAAGTTACCAAGTCTACGGGCTTTGTCCTGCCTAAGAAACCCCCTGACCAAAGAGGACAAAGAAGCAGAGACGGCGCGACT
ACTCATTATCGCCAGCATTGGCCAGCTGAAGACGCTGAACAAATGTGAGATTCTCCCCGAGGAGAGGCGGAGAGCTGAGCTTGACTACCG
AAAAGCTTTTGGAAATGAGTGGAAACAGGCTGGTGGACATAAGGATCCGGAAAAAAACAGACTCAGCGAAGAATTCCTCACAGCCCATCC
CAGATACCAGTTCCTCTGCCTGAAATATGGTGCACCTGAAGATTGGGAACTCAAAACACAGCAACCACTTATGCTGAAAAACCAGCTACT
AACACTGAAGATAAAATACCCTCATCAACTTGATCAGAAAGTCCTGGAGAAACAACTGCCGGGCTCCATGACAATTCAAAAGGTGAAGGG
ATTGCTGTCACGTCTTCTCAAAGTTCCTGTGTCAGACCTTCTGTTGTCCTATGAAAGTCCCAAAAAGCCGGGCAGAGAAATCGAGCTGGA
AAATGACCTAAAGTCATTACAGTTTTATTCTGTGGAAAATGGAGATTGTCTATTAGTGCGATGGTGACAACCAACTAATAAAATTTAAAG
ACCACACTGCTTATCGTGTCTGGGGTTCACCGGAAATAAATGATTCACTGGAACAATTCTACTGTCAAAACAAAGGGGGTTTACAACTTG

>In-frame_ENST00000366591_ENST00000406207_TCGA-BG-A0MH-01A_GPR137B_chr1_236306336_+_TBCE_chr1_235597519_length(amino acids)=445AA_start in transcript=79_stop in transcript=1416
MRPERPRPRGSAPGPMETPPWDPARNDSLPPTLTPAVPPYVKLGLTVVYTVFYALLFVFIYVQLWLVLRYRHKRLSYQSVFLFLCLFWAS
LRTVLFSFYFKDFVAANSLSPFVFWLLYCFPVCLQFFTLTLMNLYFTQVLRCVAGCPGLEELYLESNNIFISERPTDVLQTVKLLDLSSN
QLIDENQLYLIAHLPRLEQLILSDTGISSLHFPDAGIGCKTSMFPSLKYLVVNDNQISQWSFFNELEKLPSLRALSCLRNPLTKEDKEAE
TARLLIIASIGQLKTLNKCEILPEERRRAELDYRKAFGNEWKQAGGHKDPEKNRLSEEFLTAHPRYQFLCLKYGAPEDWELKTQQPLMLK

--------------------------------------------------------------
>In-frame_ENST00000366591_ENST00000543662_TCGA-BG-A0MH-01A_GPR137B_chr1_236306336_+_TBCE_chr1_235597519_length(transcript)=1554nt_BP=493nt
CTTTCCTCCAGTCTCGGGGCTGCAGGCTGAGCGCGATGCGCGGAGACCCCCGCGGGGGCGGCGGCGGCCGTGAGCCCCGATGAGGCCCGA
GCGTCCCCGGCCGCGCGGCAGCGCCCCCGGCCCGATGGAGACCCCGCCGTGGGACCCAGCCCGCAACGACTCGCTGCCGCCCACGCTGAC
CCCGGCCGTGCCCCCCTACGTGAAGCTTGGCCTCACCGTCGTCTACACCGTGTTCTACGCGCTGCTCTTCGTGTTCATCTACGTGCAGCT
CTGGCTGGTGCTGCGTTACCGCCACAAGCGGCTCAGCTACCAGAGCGTCTTCCTCTTTCTCTGCCTCTTCTGGGCCTCCCTGCGGACCGT
CCTCTTCTCCTTCTACTTCAAAGACTTCGTGGCGGCCAATTCGCTCAGCCCCTTCGTCTTCTGGCTGCTCTACTGCTTCCCTGTGTGCCT
GCAGTTTTTCACCCTCACGCTGATGAACTTGTACTTCACGCAGGTGCTGCGGTGTGTCGCGGGGTGCCCAGGCCTGGAGGAACTCTACCT
TGAGTCTAACAACATTTTCATTTCCGAAAGGCCAACAGATGTTCTCCAGACAGTCAAGTTATTAGATCTTTCCTCTAATCAATTAATTGA
TGAAAATCAGCTGTATCTGATAGCCCACCTGCCCAGGTTAGAACAATTAATCCTCTCTGACACTGGAATTTCTTCTCTACATTTTCCGGA
TGCTGGAATTGGGTGCAAAACGTCCATGTTCCCATCCTTGAAGTACCTGGTAGTAAACGACAATCAGATATCACAATGGTCGTTTTTCAA
TGAGCTAGAGAAGTTACCAAGTCTACGGGCTTTGTCCTGCCTAAGAAACCCCCTGACCAAAGAGGACAAAGAAGCAGAGACGGCGCGACT
ACTCATTATCGCCAGCATTGGCCAGCTGAAGACGCTGAACAAATGTGAGATTCTCCCCGAGGAGAGGCGGAGAGCTGAGCTTGACTACCG
AAAAGCTTTTGGAAATGAGTGGAAACAGGCTGGTGGACATAAGGATCCGGAAAAAAACAGACTCAGCGAAGAATTCCTCACAGCCCATCC
CAGATACCAGTTCCTCTGCCTGAAATATGGTGCACCTGAAGATTGGGAACTCAAAACACAGCAACCACTTATGCTGAAAAACCAGCTACT
AACACTGAAGATAAAATACCCTCATCAACTTGATCAGAAAGTCCTGGAGAAACAACTGCCGGGCTCCATGACAATTCAAAAGGTGAAGGG
ATTGCTGTCACGTCTTCTCAAAGTTCCTGTGTCAGACCTTCTGTTGTCCTATGAAAGTCCCAAAAAGCCGGGCAGAGAAATCGAGCTGGA
AAATGACCTAAAGTCATTACAGTTTTATTCTGTGGAAAATGGAGATTGTCTATTAGTGCGATGGTGACAACCAACTAATAAAATTTAAAG
ACCACACTGCTTATCGTGTCTGGGGTTCACCGGAAATAAATGATTCACTGGAACAATTCTACTGTCAAAACAAAGGGGGTTTACAACTTG

>In-frame_ENST00000366591_ENST00000543662_TCGA-BG-A0MH-01A_GPR137B_chr1_236306336_+_TBCE_chr1_235597519_length(amino acids)=445AA_start in transcript=79_stop in transcript=1416
MRPERPRPRGSAPGPMETPPWDPARNDSLPPTLTPAVPPYVKLGLTVVYTVFYALLFVFIYVQLWLVLRYRHKRLSYQSVFLFLCLFWAS
LRTVLFSFYFKDFVAANSLSPFVFWLLYCFPVCLQFFTLTLMNLYFTQVLRCVAGCPGLEELYLESNNIFISERPTDVLQTVKLLDLSSN
QLIDENQLYLIAHLPRLEQLILSDTGISSLHFPDAGIGCKTSMFPSLKYLVVNDNQISQWSFFNELEKLPSLRALSCLRNPLTKEDKEAE
TARLLIIASIGQLKTLNKCEILPEERRRAELDYRKAFGNEWKQAGGHKDPEKNRLSEEFLTAHPRYQFLCLKYGAPEDWELKTQQPLMLK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GPR137B-TBCE

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GPR137B-TBCE

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GPR137B-TBCE

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	TBCE	C1855648	KENNY-CAFFEY SYNDROME, TYPE 1	3	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	TBCE	C1855840	HYPOPARATHYROIDISM-RETARDATION-DYSMORPHISM SYNDROME	3	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	TBCE	C0004623	Bacterial Infections	1	CTD_human
Tgene	TBCE	C0029464	Osteosclerosis	1	CTD_human
Tgene	TBCE	C0282631	Facies	1	CTD_human
Tgene	TBCE	C0376634	Craniofacial Abnormalities	1	CTD_human
Tgene	TBCE	C4310667	ENCEPHALOPATHY, PROGRESSIVE, WITH AMYOTROPHY AND OPTIC ATROPHY	1	CTD_human;ORPHANET;UNIPROT
Tgene	TBCE	C4316787	Kenny-Caffey syndrome, type 2	1	CTD_human