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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GPR89B-DNM3 (FusionGDB2 ID:34353)

Fusion Gene Summary for GPR89B-DNM3

check button Fusion gene summary
Fusion gene informationFusion gene name: GPR89B-DNM3
Fusion gene ID: 34353
HgeneTgene
Gene symbol

GPR89B

DNM3

Gene ID

653519

26052

Gene nameG protein-coupled receptor 89Adynamin 3
SynonymsGPHR|GPR89|GPR89B|SH120|UNQ192Dyna III
Cytomap

1q21.1

1q24.3

Type of geneprotein-codingprotein-coding
DescriptionGolgi pH regulator Aprotein GPR89putative MAPK-activating protein PM01putative NF-kappa-B-activating protein 90dynamin-3T-dynamindynamin family memberdynamin, testicular
Modification date2020031320200313
UniProtAcc

P0CG08

Q9UQ16

Ensembl transtripts involved in fusion geneENST00000314163, ENST00000488603, 
ENST00000358155, ENST00000367733, 
ENST00000355305, ENST00000367731, 
ENST00000520906, 
Fusion gene scores* DoF score6 X 3 X 4=7219 X 17 X 5=1615
# samples 621
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1615*10)=-2.94307293191516
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPR89B [Title/Abstract] AND DNM3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGPR89B(147400691)-DNM3(172222713), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGPR89B

GO:0051452

intracellular pH reduction

18794847


check buttonFusion gene breakpoints across GPR89B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DNM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1KY-01AGPR89Bchr1

147400691

+DNM3chr1

172222713

+
ChimerDB4SARCTCGA-DX-A1KY-01AGPR89Bchr1

147400691

+DNM3chr1

172222713

+


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Fusion Gene ORF analysis for GPR89B-DNM3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000314163ENST00000358155GPR89Bchr1

147400691

+DNM3chr1

172222713

+
5CDS-intronENST00000314163ENST00000367733GPR89Bchr1

147400691

+DNM3chr1

172222713

+
5CDS-intronENST00000314163ENST00000355305GPR89Bchr1

147400691

+DNM3chr1

172222713

+
5CDS-intronENST00000314163ENST00000367731GPR89Bchr1

147400691

+DNM3chr1

172222713

+
5CDS-intronENST00000314163ENST00000520906GPR89Bchr1

147400691

+DNM3chr1

172222713

+
intron-3CDSENST00000488603ENST00000358155GPR89Bchr1

147400691

+DNM3chr1

172222713

+
intron-intronENST00000488603ENST00000367733GPR89Bchr1

147400691

+DNM3chr1

172222713

+
intron-intronENST00000488603ENST00000355305GPR89Bchr1

147400691

+DNM3chr1

172222713

+
intron-intronENST00000488603ENST00000367731GPR89Bchr1

147400691

+DNM3chr1

172222713

+
intron-intronENST00000488603ENST00000520906GPR89Bchr1

147400691

+DNM3chr1

172222713

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000314163GPR89Bchr1147400691+ENST00000358155DNM3chr1172222713+5994186751118347

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000314163ENST00000358155GPR89Bchr1147400691+DNM3chr1172222713+0.0001463320.9998536

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Fusion Genomic Features for GPR89B-DNM3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GPR89Bchr1147400691+DNM3chr1172222712+0.0172747150.9827253
GPR89Bchr1147400691+DNM3chr1172222712+0.0172747150.9827253

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GPR89B-DNM3


check button Go to

FGviewer for the breakpoints of chr1:147400691-chr1:172222713

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPR89B

P0CG08

DNM3

Q9UQ16

FUNCTION: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance (PubMed:18794847). Plays a role in lymphocyte development, probably by acting as a RABL3 effector in hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:Q8BS95, ECO:0000269|PubMed:18794847}.FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDNM3chr1:147400691chr1:172222713ENST000003553051421659_750563.0870.0DomainGED
TgeneDNM3chr1:147400691chr1:172222713ENST000003581551321659_750553.0864.0DomainGED
TgeneDNM3chr1:147400691chr1:172222713ENST000003677311320659_750553.0860.0DomainGED

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPR89Bchr1:147400691chr1:172222713ENST00000314163+114114_13414.0456.0TransmembraneHelical
HgeneGPR89Bchr1:147400691chr1:172222713ENST00000314163+114150_17014.0456.0TransmembraneHelical
HgeneGPR89Bchr1:147400691chr1:172222713ENST00000314163+114290_31014.0456.0TransmembraneHelical
HgeneGPR89Bchr1:147400691chr1:172222713ENST00000314163+114343_36314.0456.0TransmembraneHelical
HgeneGPR89Bchr1:147400691chr1:172222713ENST00000314163+114378_39814.0456.0TransmembraneHelical
HgeneGPR89Bchr1:147400691chr1:172222713ENST00000314163+114425_44514.0456.0TransmembraneHelical
HgeneGPR89Bchr1:147400691chr1:172222713ENST00000314163+11446_6614.0456.0TransmembraneHelical
HgeneGPR89Bchr1:147400691chr1:172222713ENST00000314163+1145_2514.0456.0TransmembraneHelical
HgeneGPR89Bchr1:147400691chr1:172222713ENST00000314163+11479_9914.0456.0TransmembraneHelical
TgeneDNM3chr1:147400691chr1:172222713ENST00000355305142128_294563.0870.0DomainDynamin-type G
TgeneDNM3chr1:147400691chr1:172222713ENST000003553051421515_621563.0870.0DomainPH
TgeneDNM3chr1:147400691chr1:172222713ENST00000358155132128_294553.0864.0DomainDynamin-type G
TgeneDNM3chr1:147400691chr1:172222713ENST000003581551321515_621553.0864.0DomainPH
TgeneDNM3chr1:147400691chr1:172222713ENST00000367731132028_294553.0860.0DomainDynamin-type G
TgeneDNM3chr1:147400691chr1:172222713ENST000003677311320515_621553.0860.0DomainPH
TgeneDNM3chr1:147400691chr1:172222713ENST000003553051421205_211563.0870.0Nucleotide bindingGTP
TgeneDNM3chr1:147400691chr1:172222713ENST000003553051421236_239563.0870.0Nucleotide bindingGTP
TgeneDNM3chr1:147400691chr1:172222713ENST00000355305142138_46563.0870.0Nucleotide bindingGTP
TgeneDNM3chr1:147400691chr1:172222713ENST000003581551321205_211553.0864.0Nucleotide bindingGTP
TgeneDNM3chr1:147400691chr1:172222713ENST000003581551321236_239553.0864.0Nucleotide bindingGTP
TgeneDNM3chr1:147400691chr1:172222713ENST00000358155132138_46553.0864.0Nucleotide bindingGTP
TgeneDNM3chr1:147400691chr1:172222713ENST000003677311320205_211553.0860.0Nucleotide bindingGTP
TgeneDNM3chr1:147400691chr1:172222713ENST000003677311320236_239553.0860.0Nucleotide bindingGTP
TgeneDNM3chr1:147400691chr1:172222713ENST00000367731132038_46553.0860.0Nucleotide bindingGTP
TgeneDNM3chr1:147400691chr1:172222713ENST000003553051421136_139563.0870.0RegionG3 motif
TgeneDNM3chr1:147400691chr1:172222713ENST000003553051421205_208563.0870.0RegionG4 motif
TgeneDNM3chr1:147400691chr1:172222713ENST000003553051421235_238563.0870.0RegionG5 motif
TgeneDNM3chr1:147400691chr1:172222713ENST00000355305142138_45563.0870.0RegionG1 motif
TgeneDNM3chr1:147400691chr1:172222713ENST00000355305142164_66563.0870.0RegionG2 motif
TgeneDNM3chr1:147400691chr1:172222713ENST000003581551321136_139553.0864.0RegionG3 motif
TgeneDNM3chr1:147400691chr1:172222713ENST000003581551321205_208553.0864.0RegionG4 motif
TgeneDNM3chr1:147400691chr1:172222713ENST000003581551321235_238553.0864.0RegionG5 motif
TgeneDNM3chr1:147400691chr1:172222713ENST00000358155132138_45553.0864.0RegionG1 motif
TgeneDNM3chr1:147400691chr1:172222713ENST00000358155132164_66553.0864.0RegionG2 motif
TgeneDNM3chr1:147400691chr1:172222713ENST000003677311320136_139553.0860.0RegionG3 motif
TgeneDNM3chr1:147400691chr1:172222713ENST000003677311320205_208553.0860.0RegionG4 motif
TgeneDNM3chr1:147400691chr1:172222713ENST000003677311320235_238553.0860.0RegionG5 motif
TgeneDNM3chr1:147400691chr1:172222713ENST00000367731132038_45553.0860.0RegionG1 motif
TgeneDNM3chr1:147400691chr1:172222713ENST00000367731132064_66553.0860.0RegionG2 motif


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Fusion Gene Sequence for GPR89B-DNM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000314163_ENST00000358155_TCGA-DX-A1KY-01A_GPR89B_chr1_147400691_+_DNM3_chr1_172222713_length(transcript)=5994nt_BP=186nt
AGCTTGACGGCGTCGGGCTGGAGAGCCGCAGTCCCGGCTGCAGCACCTGGGAGAAGGCAGACCGTGTGAGGGGGCCTGTGGCCCCAGCGT
GCTGTGGCCTCCGGGAGTGGGAAGTGGAGGCAGGAGCCTTCCTTACACTTCGCCATGAGTTTCCTGATCGACTCCAGCATCATGATTACC
TCCCAGGAAAAAGAAAAGAAGTACATGCTTCCCTTGGACAACCTGAAAGTTCGGGATGTGGAAAAGAGCTTTATGTCTAGCAAGCACATC
TTTGCACTCTTTAATACAGAGCAAAGGAATGTATACAAAGACTATCGCTTCCTTGAGCTGGCATGTGATTCCCAGGAGGATGTCGACAGC
TGGAAGGCATCTCTACTAAGAGCTGGGGTCTATCCTGACAAATCTGTAGGGAACAACAAAGCTGAAAATGATGAGAATGGACAAGCAGAA
AACTTTTCCATGGACCCACAATTGGAGAGGCAAGTGGAGACCATTCGCAACCTCGTAGACTCCTACATGTCCATTATCAACAAATGTATC
CGAGATCTAATTCCAAAAACAATAATGCACCTTATGATCAATAACGTTAAAGATTTCATAAATTCCGAGCTCCTAGCACAGTTGTATTCT
TCAGAGGACCAAAATACCCTGATGGAGGAATCTGCTGAGCAGGCTCAGCGCCGGGATGAGATGCTTCGAATGTATCAAGCACTGAAAGAA
GCCCTTGGGATAATTGGGGACATCAGCACAGCCACCGTGTCCACTCCGGCACCCCCTCCAGTGGATGACTCCTGGATACAGCACTCTCGC
AGGTCACCTCCTCCAAGCCCCACAACCCAAAGGAGGCCAACACTAAGTGCTCCCCTCGCAAGGCCCACATCCGGCCGAGGACCAGCTCCT
GCCATTCCCTCTCCTGGCCCCCACTCTGGGGCTCCTCCAGTCCCATTCCGTCCAGGCCCATTACCTCCTTTCCCCAGCAGCAGTGACTCC
TTCGGAGCCCCTCCACAAGTTCCATCTAGGCCTACGAGGGCCCCGCCCAGTGTCCCAAGCCGGAGACCACCCCCATCACCAACTCGTCCC
ACTATAATCCGCCCACTAGAATCCTCCCTGTTAGACTAAACGAAGTGTCTGGCATGGCAATTAATCACTAATGAATTATGCGAAAGCAAC
ATATTTGATAACCGTTGCAGTAAATCATGAGTAGTCGCATGTGTGGACATCAGTAGGCAAGTAACCAGTTTTACTAATGCATTCATCGCT
CATCTTCATTGCTCATGGTATGTCAAACCTTTGGGGTTTGACTCAGAAACTGCTAACCTTTTAGAGGCTTTATATGTTGTACTGACCAAG
GTAGGTTTGTATAGCAGCCCTATACTTTGGGGATCATTTGCCTACCATGGCATATATTTGAAATTGCTTTGGACAAGTTTTCTAGGCTAT
CTACCAGGTAGCTCATTAAACGTAATTCTTCAGATATGAGATAGTGGGCTTAGACCTAAGCCATACATATTTCTTTTCCCACATTCTGTT
TAGGATGACAGTAATTCTGTTGTCTACCATTAATGCTACTACCTACTCCATAATTGCCTATTTAGCTCCTCTTTTCTTCCTTTTTATTTC
ATAAGACTGCTAGGAAGTGATTTTTTAAAATTAGGACTCCTTAAGAATAAACTTTTCCAGAAGCACGAGGTAGTTTGCAAAGGAAAAGTC
TGCACTGTTTGCTCTAAAGAGCTTCTCCTCATTCCAATGTGTTTTGCTTCATGCTAGAAGCATATGCAACAGTGAATAAAAGCTTCTTTT
TTTGTTAATCAGTCAATAAATTTGGCTAATTAGTTTCAGAGTTCAAGGAAGAAGCAAAATATCACATCTCTAGAAGTGTTGGGAAAAATA
TAATTTCTTTCTTTACTTATATTCACCTCATGGTAGGTTATATTGAAGGCTGACATGGAGAATGTTTACTTTTCTATTTGGCATAGCTAA
CTACACTTTGATACTAACTCCAGTTTTACTATTATTATTTTGGTTGGAAAAAAAATTCACTCTTTACGTGCTAATTTGTAATCTTGTTTT
GTAAGAATTTATCCTACCCTTGAAACAGGCTCAGTGTAACTGTATATCCATTCTAGGCTTTCTTAATAAATCTTGAGGCTATGGGATAAT
CACATTTAAAGAATGGTTCCTGAAATGAAGTCAGTAGAAATGGCATGGGATAAGAGCAGAGCTCACACTTTTACAGTTGCAGTATTTCAA
AGTCCCTATCCAGGTCACTCCAGAAAAGGGTATTGAAACGTTGAAATCTAAAGCAAATTTGCAATTTCTTAAGATTTCTAAAATTTACCA
GAACAGTTTAGCCTGGGGGTTAATAGTTAAGTCTTGAGGCTAAGTTTTGGACTACCAAGGACCAGATGATTCACATGTAGGAAACAGCCA
GAAGCCAACTGGAATTTTGTGTGCTAACTGTTCCCAGACAGCAGAGCAAGTATTCACTGAGTAGGGGTGTCCCATGACACTATTTCATAT
TCTACAGAAGTAAATCAGGTTTCACCAACTGAAATGTCTCCCTTTGAAAGTAGCAAACATGATTTGTATGTTAACTTAACTTTAATTTCC
TGTGTAGTTTACACCCAGAGCAGATACTCATAAAGTATAAAGTAAAAACTTTTAACCATTATTAAACAGAGAACTTGCCATGTTGAGTGC
CATTGTATTGAACTTATTCTAAAGGCTTATGCTAACCCATTTATAATTGGTAAAAATCAGAAAATACAAGATTTACATAAAGGTCATTTC
AACTTTTAAGGTTACCAGTGATTGTATAAAAACATCACAATCCTAAATCCTCTCGTATCTCACCCCAAACCCCAAACTGGGGGAAAAAAA
GTTAACTCTTTGTGAATGGAACCAATGTGCAAGATACATACTGCATTTTTAAAATAGTGTCTCAGCTAAATGGAAAACTGTTAAGCAAAC
ATCCATAGTAAAACAAATAATCTTCAGTGAGATCTTTTTATAAAACTTCTTGTTTTTAGGATTCCCTTTGCTTCTTCCTTTGAATTCTCT
AAAATAGGCAGCTAACGGATTATATACTTCAGGGTTTGGCTTTGTGCTAAATGTGGTTTTGTGTTTTGCTGTATTTCAAAATTTTCCTTC
TGTTAAAGGAAAATATTGTGAATAACCACTGGTGTGTTCTTAGATCAGCACAAACCATGTCAAAAAAAATTGGAGATTTTTTTCCAATTT
TCCTTCCACTGATCTTAGGCAGTAATAAACAATGGCATTTGTCATCTTTGGCACTTGCTTTTAGATTATAGTCCCACAGTTGCACTGCCC
CAATTGTCTACCTTTGTGGGTACATTTTTGTTCTTTACTCCTAAGTTATTTCTCATAGAACCCAGCCTACTCTAGAATTTCAGCAGTGAC
ATTGGAGAATATTTTTAATTTGCTGCAGTACTATGTCATATTATTAGTATGAATCTCATTTCCCAAAGGGTTTGTATTCTGCTAAAAGGA
GATGCCAATGTTGAATGAAGTCTGAAACTCTAGTATGTGCATAGTTTGACGTGCAGCATGCACACCAGGCCTTAAGATGGGAATGTAGCT
TAATGATTTTCTGTTTCCCATACCATTTCTAATCTTTTGTGTAATTTTCTCTTAACTGATTGCTCTGATATTGTAAACACAATAGATGTA
GCTCTATCATGTCTAGCATAATTTAAAAAATCAGTGTTTTTAGGATTTGGGAAAATAAACTGTAAATGTTTATTTGATAGGTAAATATAG
TTTTATTGTCACATGCTAAATATTGCATGCATATTGACTAATTGGAATAACCATTTACTCAATTATGGACAGCTTATTGAAATAGTATTG
ATTTAGAAAAAGTATATTGCATTTCTAAAAAACATCTACCAAGGTTACTCGTCTGAATATTGCTTTTAGCCGTGTTTTATAACATAGACG
AGCAGTAGGGTCTGTTTATTAGCAAATTTCCTATTTGTTCCAATACAAACTCACTTTATTCTAAAGTATATTAATGAAACCAGTTCCTGT
GATGTAACTGTAAGCCTTCTCGACTTAGACTTAAAAAGTGGTCACATAGATTAATTTTGTGACTTTTTAGTATAGACTGTAGCCATAATT
CTCAAATATGAAATGGGACCTAATACCAGTATGTGATAAATGTTGATGTTTTCTGTGTACAAACACATTTTCTATGCATGTGTCTCTGTG
TATATGGCATATACCTAGTAAGTATGTTTCTGTAAGTATGTGTATTTTATGTCCATTTGAGTAGGTAGGTAGGTTTTAAAAATACTAGTT
AAAATGCCACAAGCATGAGTGTGATTGTATGTGCACTGTGTGTATATATATAAATATATGTATATGTATGGTTGTAAATATCTATGTATA
CATGTACTTAGTATGTGTGGTATCAGGATATTTTTTAAACTGTGATAATACAACAGATAGCTTTGAATGATCTGCCATAACATGTGGTAA
CAATAGTTCATTTCTCATAACATATATGAGGTATACAAAATTTTCTAACTCCAGATTGTAGTCATTTTGAGAGGTACAAAGCTCATAATT
ACCATGACAACATGGTAATGTCCATAGACATTTGTATCTGAATCCACAAGAAGATCTGAATCTAAGAAGGAATTACCTTTGACAATATTT
TTCGGTAAGAAGTAAAACCTCTGGAGACCTATCTTTAAGATCTCTAATTGGAATTATAAATTATTTTTGGATTGCTGAGCTGAATCTTAA
AAAGCCAAGTTGATATACATAGTCATTTTTCCTCTATGGTAGAAGTAAAAAAAAAAAAAAAGGACATAGCAACATTAAAGTAGTGGATTT
TTCTGAGTAAATTTGCTGAAAATATAAGAGAGAAGCTATCTAATACCTTGGAGGTAGGTCATCCACTTTTTCAGGTAAACATTTTTCATT
TGGCAAATGGCATAATTATTTGAAAGTGACAGGAATCTCCTCAGAATGAAGAATAAAGCCTACTAGGTCTCTAACTGTTGAACTCATGAA
AGAAGATAGTGTATGAGACTTAAGCCATGAGTTTTGTATCATTTCAATTAGAAGACTACTAGCTGTGAGCTCAGAGTTTAATGTAAATGA
ATCTAGATGATTTTGAAGAAATGATTATTCGTTCACCAGATCACTCATTGTACATTCTAAAAAGCTCAAATGAGTCTTCTAGATACTCTT
ACTCATCCTGTCTGGTTGCTATGTTTAAAATTATGTGGTGCTGTGTAGGTGAAACTTTAAGAATATTTTTGAAGCATATGTAATATATGC
ACTGCTATTTGTGTGTGTGTGTGTGTCTTTGTATATATGTAAGAATGTGTGTATGTGTGAGAGCAAGAGAGAGGAAACTCAAAGAGGAGT
GTTTGTCTTAAGACCTGTTCATACTGGTATATTGGTGAGACTTCTCACTTCTGGTTGGAGGTTTCACATATGGCTCAACTCAAGTCATTA
ATCTCTTTTTAATTTTTACTCTTGAATTCCTTAAACTTCGCTCATTATGAAATGTTTTAAAATTATGACAAAAATTACTCTGTCTAACCA
CTTGCCTTGTCTGCTACCAGTTTGTTAAAAATTATTCCCCCCAACCAGTAATTCCACCAGTACTACTTGATTTGTGTTATATTTCCTATG
TACATGTACAGCCTTTGTTTTGCTTGCTTGTCTATTTTTACTTTCCCTTTTTTGGGTCAAATTTTTCTTTTGCTTTGTTTGAAGAAGGAA
TATACAGAAGTAAAATCTTGTCTTCTCTGCTGATTCTTTAATTAATATGAGCCGGATACTTTCCACTGTCTTCTTGGCACTTTCAGGATT
TCTTAATGCTGATATATGGACTCTTAGAATGGAATTTTTGAAGAAAAATCTCAAAGCCTGTATCGTTCTTGAAGGTCACATGTACCTATT

>In-frame_ENST00000314163_ENST00000358155_TCGA-DX-A1KY-01A_GPR89B_chr1_147400691_+_DNM3_chr1_172222713_length(amino acids)=347AA_start in transcript=75_stop in transcript=1118
MWPQRAVASGSGKWRQEPSLHFAMSFLIDSSIMITSQEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQRNVYKDYRFLELACDSQ
EDVDSWKASLLRAGVYPDKSVGNNKAENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIPKTIMHLMINNVKDFINSELL
AQLYSSEDQNTLMEESAEQAQRRDEMLRMYQALKEALGIIGDISTATVSTPAPPPVDDSWIQHSRRSPPPSPTTQRRPTLSAPLARPTSG

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Fusion Gene PPI Analysis for GPR89B-DNM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GPR89B-DNM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GPR89B-DNM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDNM3C0022665Kidney Neoplasm1CTD_human
TgeneDNM3C0740457Malignant neoplasm of kidney1CTD_human