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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GPR89B-RNF115 (FusionGDB2 ID:34357)

Fusion Gene Summary for GPR89B-RNF115

Fusion gene summary

Fusion gene information	Fusion gene name: GPR89B-RNF115
	Fusion gene ID: 34357
		Hgene	Tgene
	Gene symbol	GPR89B	RNF115
	Gene ID	653519	27246
	Gene name	G protein-coupled receptor 89A	ring finger protein 115
	Synonyms	GPHR\|GPR89\|GPR89B\|SH120\|UNQ192	BCA2\|ZNF364
	Cytomap	1q21.1	1q21.1
	Type of gene	protein-coding	protein-coding
	Description	Golgi pH regulator Aprotein GPR89putative MAPK-activating protein PM01putative NF-kappa-B-activating protein 90	E3 ubiquitin-protein ligase RNF115RING-type E3 ubiquitin transferase RNF115rabring 7zinc finger protein 364
	Modification date	20200313	20200313
	UniProtAcc	P0CG08	.
	Ensembl transtripts involved in fusion gene	ENST00000314163, ENST00000488603,	ENST00000369291,
Fusion gene scores	* DoF score	6 X 3 X 4=72	11 X 8 X 6=528
	# samples	6	10
	** MAII score	log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/528*10)=-2.40053792958373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GPR89B [Title/Abstract] AND RNF115 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GPR89B(147400691)-RNF115(145646115), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GPR89B	GO:0051452	intracellular pH reduction	18794847
Tgene	RNF115	GO:0051865	protein autoubiquitination	16288031

Fusion gene breakpoints across GPR89B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RNF115 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AR-A1AR-01A	GPR89B	chr1	147400691	+	RNF115	chr1	145646115	+

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Fusion Gene ORF analysis for GPR89B-RNF115

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000314163	ENST00000369291	GPR89B	chr1	147400691	+	RNF115	chr1	145646115	+
intron-3CDS	ENST00000488603	ENST00000369291	GPR89B	chr1	147400691	+	RNF115	chr1	145646115	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000314163

GPR89B

chr1

147400691

ENST00000369291

RNF115

chr1

145646115

8997

186

998

307

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000314163	ENST00000369291	GPR89B	chr1	147400691	+	RNF115	chr1	145646115	+	0.013756444	0.98624355

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Fusion Genomic Features for GPR89B-RNF115

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GPR89B	chr1	147400691	+	RNF115	chr1	145646114	+	0.000307242	0.9996928
GPR89B	chr1	147400691	+	RNF115	chr1	145646114	+	0.000307242	0.9996928

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GPR89B-RNF115

Go to
FGviewer for the breakpoints of chr1:147400691-chr1:145646115
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GPR89B P0CG08	.
FUNCTION: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance (PubMed:18794847). Plays a role in lymphocyte development, probably by acting as a RABL3 effector in hematopoietic cells (By similarity). {ECO:0000250\|UniProtKB:Q8BS95, ECO:0000269\|PubMed:18794847}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RNF115

chr1:147400691

chr1:145646115

ENST00000369291

228_269

34.0

305.0

Zinc finger

RING-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GPR89B

chr1:147400691

chr1:145646115

ENST00000314163

114_134

14.0

456.0

Transmembrane

Helical

Hgene

GPR89B

chr1:147400691

chr1:145646115

ENST00000314163

150_170

14.0

456.0

Transmembrane

Helical

Hgene

GPR89B

chr1:147400691

chr1:145646115

ENST00000314163

290_310

14.0

456.0

Transmembrane

Helical

Hgene

GPR89B

chr1:147400691

chr1:145646115

ENST00000314163

343_363

14.0

456.0

Transmembrane

Helical

Hgene

GPR89B

chr1:147400691

chr1:145646115

ENST00000314163

378_398

14.0

456.0

Transmembrane

Helical

Hgene

GPR89B

chr1:147400691

chr1:145646115

ENST00000314163

425_445

14.0

456.0

Transmembrane

Helical

Hgene

GPR89B

chr1:147400691

chr1:145646115

ENST00000314163

46_66

14.0

456.0

Transmembrane

Helical

Hgene

GPR89B

chr1:147400691

chr1:145646115

ENST00000314163

5_25

14.0

456.0

Transmembrane

Helical

Hgene

GPR89B

chr1:147400691

chr1:145646115

ENST00000314163

79_99

14.0

456.0

Transmembrane

Helical

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Fusion Gene Sequence for GPR89B-RNF115

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000314163_ENST00000369291_TCGA-AR-A1AR-01A_GPR89B_chr1_147400691_+_RNF115_chr1_145646115_length(transcript)=8997nt_BP=186nt
AGCTTGACGGCGTCGGGCTGGAGAGCCGCAGTCCCGGCTGCAGCACCTGGGAGAAGGCAGACCGTGTGAGGGGGCCTGTGGCCCCAGCGT
GCTGTGGCCTCCGGGAGTGGGAAGTGGAGGCAGGAGCCTTCCTTACACTTCGCCATGAGTTTCCTGATCGACTCCAGCATCATGATTACC
TCCCAGGAATATATATGTCCCAGATGTGAATCAGGCTTTATTGAAGAAGTGACAGATGATTCCAGTTTTTTAGGTGGTGGCGGCAGTCGG
ATAGACAATACCACAACAACACATTTTGCAGAGCTTTGGGGCCATTTGGATCACACGATGTTTTTTCAAGATTTTAGACCCTTTCTAAGT
AGCAGTCCACTGGACCAAGATAATAGAGCCAATGAAAGGGGTCACCAGACTCACACTGACTTCTGGGGAGCAAGACCTCCACGGTTGCCA
TTGGGTCGGAGATACAGATCTCGAGGAAGTTCTCGTCCTGACAGATCTCCAGCTATTGAAGGAATACTACAACACATCTTTGCAGGATTC
TTTGCAAATTCTGCCATTCCTGGATCTCCACACCCTTTTTCCTGGAGCGGGATGCTGCACTCCAACCCTGGGGACTATGCCTGGGGTCAG
ACAGGGCTTGATGCCATTGTAACCCAGCTTTTAGGACAACTGGAAAACACAGGCCCTCCCCCAGCTGACAAGGAAAAGATCACATCTCTT
CCAACAGTGACAGTAACTCAGGAACAAGTTGATATGGGTTTAGAGTGTCCAGTATGCAAAGAAGATTACACAGTTGAAGAGGAAGTCCGG
CAGTTACCTTGCAATCACTTCTTTCACAGCAGTTGTATTGTGCCGTGGCTAGAACTGCATGACACATGTCCTGTATGTAGGAAGAGCTTA
AATGGTGAGGACTCTACTCGGCAAAGCCAGAGCACTGAGGCCTCTGCAAGCAACAGATTTAGCAATGACAGTCAGCTACATGACCGATGG
ACTTTCTGAAGCTAAAGACCACACCTGAATCAGGGCTGTGGTAATCATCTTACCATAGCTGTAAATTGTATCAAAACAAAAAATTAGTAG
ATGGATTTAGGAATATGTAAGAAACTCAACACATAATATAAATGCAATGAATGTTTTTCTTCTTTAAATTTAAAGTTAGTATCTACAGAT
GGAATTGTATCTACAACCAAATGCCTCTTATCCCTGAATTCAGAGTGATAATTTTATAAGTGTGAAACTTAATTATGTAGGGCTCCCCCC
GTCTGAATAGAATTAATTCCTTAAAGTCTAGTTAGGGTCCTGCTGTCTGTCATGTTGCCTTGTAACGGATGTTTCCACCTCCTTCTCCAA
CCTCTACCCCACCATTAGTGTATTTTACTATAAAAACAGTGGAACCACAGCCCTAAAGTCCTGCTGATATAAAGTCCTTTTGTCTTAATT
GTATTTAAAAAAAAAAAAAAACTACTCTTGATCACATTAGCTATGAGGCGAGGTCAAATTCAGGTATCTAAGACTAATGATTTTGTTTTG
TCTTGATCCCCAGAGAGCAAATCAAAGAAAAATTACAGCAAGAAGAGAAAAGTGGTTTATCATTGTGTGCTTTGGTTTTCTTATTTTAAT
TTTTTTTGTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTCGCCTAGGCTGGAGTGCAGTGGCACGATCTTGGCTCATTGCAAACTCTGC
CTCCTGAGTTCAAGCGATTCTCCTACCTCAGCCTCCAGAGTAGCTGGGACCACAGGCATTTGTTACCATGCCCAGCTAATTTTTTGTATA
TTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCAATCTCCTGACCTTGTGCTCCGCCTGCCTCAGCCTCCCAAAGTGCTG
GGATTACAGGCGTGAGCCACTGCGCCTGGCCTCTTATTTTAATTTTTAAAGACTACTTCAGTTGATGCAGTTTCCCAAGAAACCTACATA
ACATATATTGGGAGCCTTATGTTGATAGGAATCTGATTCCCATTCCTTTTTGGGAATGAGTTGGGCAGCATACAGGCACAGAAAGACAGA
TGTTTGAGACCTTTGCTTCTGAGATTTTAAAAAATGATTACCGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCG
AGGCAGGCGGATCACAAGGTCAAGAGATCAAGACCAGCCTGGCCAACAAGGTAAAACCTTGTCTCTACTAAAAATATAAAATTAGCTGGG
CCTGGTGGTGCATGCCTGTAATCCCAGCTACTCATGAGGCTGAGGTGGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCGGTGAGCCG
GATCATACCAATGCACTCCAGTCTGGGCAACAAGAGCGAAACTCCATCTCAAAAAAAAAAAAAAAATCCCCAACTCACTGCTTTTTTTGT
TTGTTTCTGTCGCCTAGGCTGGAGTGCAGTGGCACGATCTCAGCTCACCACAGCCTCGACCTCCCAGGCTCAAGTGATCCTCCCACCTCA
GCCTACCAAGTGGCTGGGACTACAGGCGTGTGCCACCATGCCTGGGTAATTTTTGTATTTTTGTAGAGATAGGGTTTTGCCGTGTTGCCC
AGGCTGGTCTCAAACTCCTGGGCTCAAGTGATCTGCCTGCCTCAACCTCTCAAAGTGCTCAACTCATTGTTTACTGTCTTTTTTCCTAGT
AATCTTAAAATAATTTGCCTCACAGAAATAGAGACAGTAAGTGTCTGCAGCCAGTTCACTGTTTTTGGTAATTCATTGGTCTTCAGGAGT
TAAGATTTTACATTGTCACATTTTAATTTTTAAGCCTATTTTTCATCTCTGAAACTTTCCTTTTCTCCTTGGTTCTGGCTATACTTGGAC
TCAAACTGATCAGTGTGATCATGTCCAAAACAGCTTGGCCTGGAAGAGGTAGGCCTTATTTTTTCAGCCTAGTAGTGTCCCATGCACATG
CTCTTTGTAGCATTCAAGTGTTTAACATTGGATAAATTAAGAAGGTCAAGAATGTTGTTGAAACTTCAAGGTCTCAAAAGGAAATGATGG
GGACATAGAACAACTGTTGGTGTACCAAAAAAAGGTACAGAGGGGCACCATTTGTATTGTCACACAACAATGATCAGAATGATCAGTTTA
GAATGATCAGAACAAAAACACCACTCTTTAATGGGTCTTTTTCTTGGCTAGAAGTCTTTCCTCAGTTTTTGTTGACTATCATACGCTGAT
TTGTGGGTGACGGAAGGGGGCTAGAGATAACGTTTCTCTGTACTTTGGTAAAGGATGAAGGAGTCAGAGAGGGAACAGAAAAAGTGAGAG
AGTGGCCTGCTGAAATAATAGCCTGCCTCTAAAAGTTGTGACCAGAAAGTATGATTCATTTGGGCCCAGAGGGAATAAAATATGTTTTTT
CATATACCTCCCATATTACACCTCTGTAGTGATTGTTTATTTGGGGAATGAGATCTACTTACTGTGCGTTGCCCCTGAAATGTAGCTTGA
GAATACACACTGGTTTTGAATTGGGGAGGAGGATGGAAGGAAATTAGAGGTGTATTATGAATATTTGGCCACTACTTAGATGGAGGAAGG
CTATGTTGAACTTGGGACACATTGCAGTTTTCAAGTACACAATATCAGTTGTCTCAGAAAAATCATGACAGCCTGGACATATTTGCTTGT
CAGTGTCTGGAGATGCCAGGACAGGCAGTTGTAGTTTTACGTACAGATAGAGAACCAATGCCTAGAGAACTAGAAAGGATCTGAGTAGCT
TTAAAAAGGGTGGAAACAAAGTACTGGATAGGGGTCTGCCTTTTTATACACAGTATAGCAAACAGCATCAGACAAAGTTACATGAAGTTT
TCTTCACTTTTTTTGCTCTGATGGATAGAGGATGTGAGACTCATTTTACTGTTTCCCAGACCTGTCCCACTTAATGGATCTGTTGTGTTT
CTTCTTATAATGGCAGGCACCTCAGATGTCCAGGTTAATTTATGTTGAGGAGTTAGGATTCTTCAGGGATTTATTATTATTATTATTATT
ATTTATTTATTTATTTATTTATTTATTTATTTTTTGAGATGGAGGCTTGCTCTGTCGCCTAGGCTGGAGTGCAGTGGCGCAATCTCAGCT
CACTGCAACCTCCACCTCCTGGGTTCCAGCGATTCTTCTGCCTTAGCCTCCCAAGCAGCTGGGATTACAGGCACCTGCCACCATGCCCAG
CTAATTTTTTATATGTTTAGTAGAGACAAGGTTTTACCTTGTTGGCCAGGCTGGTCTTGAACTCTAGACCTCAGGTGATCTGCCAGTCGT
GGCCTCCCAAAGTGCTGGGATTACAGACGGGAGCCACCATGCCCAGCCTGAGATTTATTATAAGGAATTGGTTCACACAATAATGGAGTT
TGAGAAATCCCAAGATCTGCAGTGGGCCAGCTAGAGATCCAGGAGAGCTGATGGTGTAGTTCCAGTCTGAAGGCCAGCTTGGATACCCTA
GAAGAGCTGATGTTTCTGTTCCAGTTCAGAGGCAGGAAAAGACTGAGGTCTTAGTTCAAGCAGTCAGGCAGGAGGACTTCTCCCTTACTT
GTTCTATTCAGACCTTCAACTGATTGGATGAGGGCCACTTACATTAGGGAGGGCCATGTGCTGTATTCAGTCTACTGACTGAAATGTTAG
TCTCTTCCAAAAACACCCTCACAGACACACCCAGAATACTGTATGACCAAATATCTGGGCATCATGTGGCCTAGTCAAGTTGACACATAA
GATTAACCATCACAATGAGGAAAAACAGAAATGATACATGTATACAGAGTGCTCCTCATCCCAATTAAGTTTCACCAAGTTAATAATGTG
TCTCTATGAGAAGTGGTTCACCATGTTGGTCAGGCTGTTTTCAAACTCCTGACCTCAGGTGACCACCCGCCTCGGCCTCCCAAAGTGCTG
GGATTACAGGTGTGAGCTAGCACTCCCAGCCGACAGGTGCTTCTTAAATGTTTTCTTTGAGCAGGAATTGGTCCAGGAATTGGTTCTCAA
GTTAGAAGGAAAATTTGAGGGGAAGAACTTGTTTTTTCTCCAATCAGTCTCTGATTAAATAGTTATTAGGAAAAACTCCTTGCTTATGTC
TTTGTATTGCACATTTTTATATATGTATATATGTGTAAATAGAGATATTTATATATTCACAGACAAACACGTGTATGCACATTTCACAAT
GGAGGAAGAAGGGATATGGTGTGCACTGAGGTAAAGTGAGCAGGGATACAGAAGAGAGCTGGAGCCTCACAGTCTGATTCTCTCATTGTA
CATAACCTTTAGGGTCTTTGTTTCCCTGAGTTCTCTGGTATGGGGCACTGTTGGCTTGGGCTGGTACCCTGTTATTCTCTGTGATGAAGG
GATTCACTGGAGGTAAAAACGTAATCATTTCCAAAGGTTGAGAATAAATGACTTTGAGGAAAGGGTGTTCATTATCCGTTGCTTCTATAT
TATAATCAGTTGAACTACAATACGGTTATCTATTGATTTTTTTTAATTTTTCTGACAAATTATTGACACCAAATTGAATAATTCATGACC
TGCATGCTTCAGCTTCTTTCTCCCTGGTTTCCAGGTGCTATTCCCTCAAGAAATGCAAATTAAATATGTCGGTCTTAATAAATCAGGAGG
GAAGCATAGTCTGTGTCTGTTTTAAATGACAACAACAACAAAACAGCTTTGGGGTTTAAGAAGTGGAAGACACATTTTTATTTTTTTGAG
ACACAATCTCACTCTTTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGGTCACTGCAACCTCCCGCTCCTGGGTTCAAGCGATTCTCT
TGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACGTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTTGCCA
TGTTGCCCAGGCTGGTCTCGAACTCCTGATGTCAAGTGATCACCGACCTCAGCATCCCAAAGTGCTGGGATTACAGGCATTAGCCACCAC
GCCCAGGTGAGAAGACAGATTTTAAGAGAAGGAGCAGGGCTGGTATCTGAATAGGTATTTGGATGTTAGGGGAAAACCCTTTTTGGCCTC
TGTGGTAGAGCGATCGGAAGGTAAAAGTGCTGTTTACAAGAATAATCCATTGGAGATCTGGGGATTGGGGACGACTTATAGGATAGAGTC
CTCTTGTTGAGAATTTCCCGAATGAATCTCATGTAGGTTCTGTCACAGTAAGATGGAGGAAAACTTTGATGGGGTAAGTATCACAAGTGG
CTGTCCTATAGGGGGAAATCCTAGCCTGCAGTAATGTCAGTGTCTCAGTATTCAGCCAGCGAGCCACTGAGCTGCTCCAGGGGTTTAAAA
TAGAATGCATAGAATACAATGTATACAGCTGGTGATGCTTTCCAGGATCAAAATAGAGCCCTTGTCTGATCCCATTGACATTGTAAGGTT
TCGATCTCTCATACCTGCCACAGACAAGTACATTGTAGGCATTCAACTTTTAAGGTTTTATACATGCAAACTTTATGTTTTCCTGCCACA
CTACACTTGGTGTCCACAGAAGTGTAGTTTGTATGTTGCCTCTTCTTCCTCTTTCAACCAGAACACTTAGATCTGTGATCATAGGATGTA
AGCCTGTGATTCTTTACTTTTTCTAATAAGAAATACAATTTTCAAGATCCAAAAATTATTAGATTCTTGGCTGGGCATTGTGGCTCATGC
CTGTAATCTCAGCATTTTGGAAGGCTGAGGCAGGCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGGCAGCACAATAAAACACCA
TGTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGCATGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGAGGGAGAATCGTTTG
AACCAAGGAGGCAGAGGTTGTAGTGAGCCAAGATTGTGCCACTGCACTCCAGGGCAACAGAGAGAGACCCTGTCTCAAAACAAAAACCCC
CAAATTATTAGATTCCCTTCCAACAACTTGATAGCCATATTATTAGTATTTTTGATTAAAGAATACATAACAAAAAGCTGCTATGATTTC
AGTAATGCTTTTAAGTTAATTTATTAGTCACACCAGAATCTACATCCAATTGAAATATATACAAATATTTGAAAGATATTTATTCAGGCT
GAAGATTATGGTATATAGATTCCTTCTGATAACCTCATGGCCTCACAGGTTCAAAACCCGTGTTTGTGAATCACTCATACAGATTGGGGC
TAAGATGCGTGTCCAGAAAACCACCTATTATGCATGAAAATTTGTAGGCTTATTTGAAGGCAATTGTATCAACACATTTTGAAAGCCAAG
ACACAAGTATTTTAAGTTTCTGTTTAACCAAGTCTCGAGATAAGCAGAGTAAATAAACTCTTTAGAAGCAAGACTCAGTTGGTATGTACA
AAGTGGGATTGCTTTGTATATATTCCGCTTAGTTTGAGTCAGAGCTAGTAATCTGATGCTCTTAAATGTCTTCATAAACTTGGGCAGTGA
TGTTTCCTTTCTGTGATTATGTGTCACAGATTTTTATATGTGGACTATAATTAGTATAGTACAATGGCTGAAACTTTTCCTATAGTTGGA
TATATCTTCTGAGACTTCCAGTGATTGTATAATGTTGAGTAGCTCCAGAAGATTATTTGAATAGTAAAAACAAAAGACATCTCTACCTAT
GTGAGTTTATTATTTAGTTAGAAACACAGAACTAACTATTTAAAACAGGTAGAGAAAGATTAAGATGAATGTGATGTAGTGGAGAAAGCT
TTGGAGACTTTGGAGTCAGAACTCAAATGGCTCTAGGTCCCAAATCCAGACTCTCATTTTGATTCTCAGAACAATTCTGTGGAAAGAGAA
GATACAATAGGCAATATCCCTTTTTACAGATAGGTAAACAGAAATAGCATCTCAAAACCTCATTTGCACTGGGTGAGGTGGCTCACGCCT
GTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCGTC
TCTACCAAAAACACAAAAATTAGCCAGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTTGGGAGACTGAGGCAGGAGAATTGCTTGAA
CCCGGGAGGTGGAGGTTGCAGTGAGCTGAGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTCCGTCTCAAAAAAAAAAAA
AAAAATTCATTTGCCCAATGACAAATAGCTGGTATGTTGCAGAGCCAGAATTTGAATCCAGGTCTTTTTGCCTCCATGGCTAGTCCTTTT
ATCTCCATGGGATACAGTCTAAAATCCTTAGTTTGAGGTTCAAGACTATCACTAATAAGAGTCTTACTCATCTACTTCAGCCATATCTCT
TTCCGTTCCCACAAACCTTAGCTCCCACATTTGGCAGGTCCTTGCCAAGGAGCACAGGTAAAGTGTCTCTTTCCTTTTAATGGCTCACCA
TGGAGCTGTAGCTAAATTTCTGTGCTCTTACCCCTTTATTCATGTAGTTCCTCCTATCAGGAATATCCTGCCCACTCTCTGCTTAACTAT
GACAAGAGGTCATCTGTCCAAAGAGAAAGAAGAGAGTTTGTGGATTTAGGAGAAAAGAAAATACTCCAAATACTGCTATGGGCATTTATT
TAAAAAGAGAAATGACCAAAGAGGTTAACAAGTATTTAGATGAAGCTGGGCAGTTGTAGTCTGTGGTGCTCTTGGTCTGCACAAATCTTC
CTCTTCCTCCAGCAGTGCTGTATGGATGTTGTTGAATGTTGAGGTCTGTCTGCATTTTCTCATTTTCATGCCAAGTCAATCACTGGATCT

>In-frame_ENST00000314163_ENST00000369291_TCGA-AR-A1AR-01A_GPR89B_chr1_147400691_+_RNF115_chr1_145646115_length(amino acids)=307AA_start in transcript=75_stop in transcript=998
MWPQRAVASGSGKWRQEPSLHFAMSFLIDSSIMITSQEYICPRCESGFIEEVTDDSSFLGGGGSRIDNTTTTHFAELWGHLDHTMFFQDF
RPFLSSSPLDQDNRANERGHQTHTDFWGARPPRLPLGRRYRSRGSSRPDRSPAIEGILQHIFAGFFANSAIPGSPHPFSWSGMLHSNPGD
YAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLECPVCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GPR89B-RNF115

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for GPR89B-RNF115

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GPR89B-RNF115

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	RNF115	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	RNF115	C0678222	Breast Carcinoma	1	CTD_human
Tgene	RNF115	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	RNF115	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	RNF115	C4704874	Mammary Carcinoma, Human	1	CTD_human