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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GRB7-CDK12 (FusionGDB2 ID:34537)

Fusion Gene Summary for GRB7-CDK12

check button Fusion gene summary
Fusion gene informationFusion gene name: GRB7-CDK12
Fusion gene ID: 34537
HgeneTgene
Gene symbol

GRB7

CDK12

Gene ID

2886

51755

Gene namegrowth factor receptor bound protein 7cyclin dependent kinase 12
Synonyms-CRK7|CRKR|CRKRS
Cytomap

17q12

17q12

Type of geneprotein-codingprotein-coding
Descriptiongrowth factor receptor-bound protein 7B47GRB7 adapter proteinepidermal growth factor receptor GRB-7cyclin-dependent kinase 12CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12
Modification date2020031320200313
UniProtAcc.

Q9NYV4

Ensembl transtripts involved in fusion geneENST00000309156, ENST00000309185, 
ENST00000394211, ENST00000578702, 
ENST00000445327, ENST00000394209, 
ENST00000394204, 		ENST00000430627, 
ENST00000447079, ENST00000559545, 
Fusion gene scores* DoF score23 X 20 X 8=368036 X 30 X 14=15120
# samples 4255
** MAII scorelog2(42/3680*10)=-3.13124453327825
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(55/15120*10)=-4.78088271069641
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRB7 [Title/Abstract] AND CDK12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGRB7(37894386)-CDK12(37721013), # samples:2
GRB7(37902455)-CDK12(37700502), # samples:2
GRB7(37902455)-CDK12(37680927), # samples:2
Anticipated loss of major functional domain due to fusion event.GRB7-CDK12 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
GRB7-CDK12 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
GRB7-CDK12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
GRB7-CDK12 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGRB7

GO:0030335

positive regulation of cell migration

10893408|12021278

TgeneCDK12

GO:0046777

protein autophosphorylation

11683387


check buttonFusion gene breakpoints across GRB7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CDK12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-1736-01BGRB7chr17

37894386

+CDK12chr17

37721013

+
ChimerDB4READTCGA-AF-A56L-01AGRB7chr17

37902455

+CDK12chr17

37700502

+
ChimerDB4STADTCGA-CG-4449GRB7chr17

37902455

+CDK12chr17

37680926

+
ChimerDB4OVTCGA-61-1736-01BGRB7chr17

37894386

+CDK12chr17

37721013

+
ChimerDB4READTCGA-AF-A56LGRB7chr17

37902455

+CDK12chr17

37700502

+
ChimerDB4STADTCGA-CG-4449-01AGRB7chr17

37902455

+CDK12chr17

37680927

+
ChimerDB4STADTCGA-CG-4449-01AGRB7chr17

37902455

-CDK12chr17

37680927

+


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Fusion Gene ORF analysis for GRB7-CDK12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000309156ENST00000430627GRB7chr17

37894386

+CDK12chr17

37721013

+
5UTR-intronENST00000309156ENST00000447079GRB7chr17

37894386

+CDK12chr17

37721013

+
5UTR-3UTRENST00000309156ENST00000559545GRB7chr17

37894386

+CDK12chr17

37721013

+
5UTR-intronENST00000309185ENST00000430627GRB7chr17

37894386

+CDK12chr17

37721013

+
5UTR-intronENST00000309185ENST00000447079GRB7chr17

37894386

+CDK12chr17

37721013

+
5UTR-3UTRENST00000309185ENST00000559545GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000394211ENST00000430627GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000394211ENST00000447079GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-3UTRENST00000394211ENST00000559545GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000578702ENST00000430627GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000578702ENST00000447079GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-3UTRENST00000578702ENST00000559545GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000445327ENST00000430627GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000445327ENST00000447079GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-3UTRENST00000445327ENST00000559545GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000394209ENST00000430627GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000394209ENST00000447079GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-3UTRENST00000394209ENST00000559545GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000394204ENST00000430627GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000394204ENST00000447079GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-3UTRENST00000394204ENST00000559545GRB7chr17

37894386

+CDK12chr17

37721013

+
5CDS-intronENST00000309156ENST00000430627GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000309156ENST00000447079GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000309156ENST00000559545GRB7chr17

37902455

+CDK12chr17

37700502

+
3UTR-intronENST00000309185ENST00000430627GRB7chr17

37902455

+CDK12chr17

37700502

+
3UTR-intronENST00000309185ENST00000447079GRB7chr17

37902455

+CDK12chr17

37700502

+
3UTR-intronENST00000309185ENST00000559545GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000394211ENST00000430627GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000394211ENST00000447079GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000394211ENST00000559545GRB7chr17

37902455

+CDK12chr17

37700502

+
intron-intronENST00000578702ENST00000430627GRB7chr17

37902455

+CDK12chr17

37700502

+
intron-intronENST00000578702ENST00000447079GRB7chr17

37902455

+CDK12chr17

37700502

+
intron-intronENST00000578702ENST00000559545GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000445327ENST00000430627GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000445327ENST00000447079GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000445327ENST00000559545GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000394209ENST00000430627GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000394209ENST00000447079GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000394209ENST00000559545GRB7chr17

37902455

+CDK12chr17

37700502

+
3UTR-intronENST00000394204ENST00000430627GRB7chr17

37902455

+CDK12chr17

37700502

+
3UTR-intronENST00000394204ENST00000447079GRB7chr17

37902455

+CDK12chr17

37700502

+
3UTR-intronENST00000394204ENST00000559545GRB7chr17

37902455

+CDK12chr17

37700502

+
Frame-shiftENST00000309156ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680926

+
Frame-shiftENST00000309156ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680926

+
5CDS-intronENST00000309156ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680926

+
3UTR-3CDSENST00000309185ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680926

+
3UTR-3CDSENST00000309185ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680926

+
3UTR-intronENST00000309185ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680926

+
Frame-shiftENST00000394211ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680926

+
Frame-shiftENST00000394211ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680926

+
5CDS-intronENST00000394211ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680926

+
intron-3CDSENST00000578702ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680926

+
intron-3CDSENST00000578702ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680926

+
intron-intronENST00000578702ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680926

+
Frame-shiftENST00000445327ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680926

+
Frame-shiftENST00000445327ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680926

+
5CDS-intronENST00000445327ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680926

+
Frame-shiftENST00000394209ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680926

+
Frame-shiftENST00000394209ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680926

+
5CDS-intronENST00000394209ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680926

+
3UTR-3CDSENST00000394204ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680926

+
3UTR-3CDSENST00000394204ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680926

+
3UTR-intronENST00000394204ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680926

+
Frame-shiftENST00000309156ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680927

+
Frame-shiftENST00000309156ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680927

+
5CDS-intronENST00000309156ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680927

+
3UTR-3CDSENST00000309185ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680927

+
3UTR-3CDSENST00000309185ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680927

+
3UTR-intronENST00000309185ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680927

+
Frame-shiftENST00000394211ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680927

+
Frame-shiftENST00000394211ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680927

+
5CDS-intronENST00000394211ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680927

+
intron-3CDSENST00000578702ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680927

+
intron-3CDSENST00000578702ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680927

+
intron-intronENST00000578702ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680927

+
Frame-shiftENST00000445327ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680927

+
Frame-shiftENST00000445327ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680927

+
5CDS-intronENST00000445327ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680927

+
Frame-shiftENST00000394209ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680927

+
Frame-shiftENST00000394209ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680927

+
5CDS-intronENST00000394209ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680927

+
3UTR-3CDSENST00000394204ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680927

+
3UTR-3CDSENST00000394204ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680927

+
3UTR-intronENST00000394204ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680927

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GRB7-CDK12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GRB7chr1737894386+CDK12chr1737721012+1.32E-050.9999869
GRB7chr1737902455+CDK12chr1737680926+4.51E-060.99999547
GRB7chr1737902455+CDK12chr1737680926+4.51E-060.99999547
GRB7chr1737894386+CDK12chr1737721012+1.32E-050.9999869
GRB7chr1737902455+CDK12chr1737680926+4.51E-060.99999547
GRB7chr1737902455+CDK12chr1737680926+4.51E-060.99999547

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRB7-CDK12


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CDK12

Q9NYV4

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GRB7-CDK12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GRB7-CDK12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GRB7-CDK12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GRB7-CDK12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGRB7C0006142Malignant neoplasm of breast2CTD_human
HgeneGRB7C0678222Breast Carcinoma2CTD_human
HgeneGRB7C1257931Mammary Neoplasms, Human2CTD_human
HgeneGRB7C1458155Mammary Neoplasms2CTD_human
HgeneGRB7C4704874Mammary Carcinoma, Human2CTD_human
HgeneGRB7C0001418Adenocarcinoma1CTD_human
HgeneGRB7C0007134Renal Cell Carcinoma1CTD_human
HgeneGRB7C0024121Lung Neoplasms1CTD_human
HgeneGRB7C0033578Prostatic Neoplasms1CTD_human
HgeneGRB7C0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneGRB7C0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneGRB7C0205643Carcinoma, Cribriform1CTD_human
HgeneGRB7C0205644Carcinoma, Granular Cell1CTD_human
HgeneGRB7C0205645Adenocarcinoma, Tubular1CTD_human
HgeneGRB7C0242379Malignant neoplasm of lung1CTD_human
HgeneGRB7C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneGRB7C0376358Malignant neoplasm of prostate1CTD_human
HgeneGRB7C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneGRB7C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneGRB7C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneGRB7C1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneCDK12C0033578Prostatic Neoplasms1CTD_human
TgeneCDK12C0376358Malignant neoplasm of prostate1CTD_human