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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GRB7-ITGB3 (FusionGDB2 ID:34541)

Fusion Gene Summary for GRB7-ITGB3

check button Fusion gene summary
Fusion gene informationFusion gene name: GRB7-ITGB3
Fusion gene ID: 34541
HgeneTgene
Gene symbol

GRB7

ITGB3

Gene ID

2886

3690

Gene namegrowth factor receptor bound protein 7integrin subunit beta 3
Synonyms-BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT
Cytomap

17q12

17q21.32

Type of geneprotein-codingprotein-coding
Descriptiongrowth factor receptor-bound protein 7B47GRB7 adapter proteinepidermal growth factor receptor GRB-7integrin beta-3antigen CD61integrin beta 3integrin beta chain, beta 3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)platelet membrane glycoprotein IIIa
Modification date2020031320200329
UniProtAcc.

Q13352

Ensembl transtripts involved in fusion geneENST00000309156, ENST00000309185, 
ENST00000394211, ENST00000578702, 
ENST00000445327, ENST00000394209, 
ENST00000394204, 		ENST00000559488, 
ENST00000571680, ENST00000435993, 
ENST00000560629, 
Fusion gene scores* DoF score23 X 20 X 8=36805 X 4 X 5=100
# samples 425
** MAII scorelog2(42/3680*10)=-3.13124453327825
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRB7 [Title/Abstract] AND ITGB3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGRB7(37900460)-ITGB3(45351785), # samples:3
Anticipated loss of major functional domain due to fusion event.GRB7-ITGB3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
GRB7-ITGB3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGRB7

GO:0030335

positive regulation of cell migration

10893408|12021278

TgeneITGB3

GO:0033627

cell adhesion mediated by integrin

12807887

TgeneITGB3

GO:0034446

substrate adhesion-dependent cell spreading

24658351

TgeneITGB3

GO:0099149

regulation of postsynaptic neurotransmitter receptor internalization

18549786


check buttonFusion gene breakpoints across GRB7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ITGB3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0CX-01AGRB7chr17

37900460

+ITGB3chr17

45351785

+
ChimerDB4BRCATCGA-A2-A0CX-01AGRB7chr17

37900460

+ITGB3chr17

45351785

+
ChimerDB4BRCATCGA-A2-A0CX-01AGRB7chr17

37900460

+ITGB3chr17

45351785

+


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Fusion Gene ORF analysis for GRB7-ITGB3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000309156ENST00000559488GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000309156ENST00000571680GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000309156ENST00000435993GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000309156ENST00000560629GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000309185ENST00000559488GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000309185ENST00000571680GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000309185ENST00000435993GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000309185ENST00000560629GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000394211ENST00000559488GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000394211ENST00000571680GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000394211ENST00000435993GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000394211ENST00000560629GRB7chr17

37900460

+ITGB3chr17

45351785

+
intron-3CDSENST00000578702ENST00000559488GRB7chr17

37900460

+ITGB3chr17

45351785

+
intron-3CDSENST00000578702ENST00000571680GRB7chr17

37900460

+ITGB3chr17

45351785

+
intron-5UTRENST00000578702ENST00000435993GRB7chr17

37900460

+ITGB3chr17

45351785

+
intron-5UTRENST00000578702ENST00000560629GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000445327ENST00000559488GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000445327ENST00000571680GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000445327ENST00000435993GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000445327ENST00000560629GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000394209ENST00000559488GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000394209ENST00000571680GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000394209ENST00000435993GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000394209ENST00000560629GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000394204ENST00000559488GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000394204ENST00000571680GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000394204ENST00000435993GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000394204ENST00000560629GRB7chr17

37900460

+ITGB3chr17

45351785

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GRB7-ITGB3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GRB7chr1737900460+ITGB3chr1745351784+0.99961230.000387736
GRB7chr1737900460+ITGB3chr1745351784+0.99961230.000387736

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRB7-ITGB3


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ITGB3

Q13352

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269|PubMed:11713274, ECO:0000269|PubMed:12244126, ECO:0000269|PubMed:15082778, ECO:0000269|PubMed:15254226, ECO:0000269|PubMed:16622420}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GRB7-ITGB3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GRB7-ITGB3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GRB7-ITGB3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GRB7-ITGB3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGRB7C0006142Malignant neoplasm of breast2CTD_human
HgeneGRB7C0678222Breast Carcinoma2CTD_human
HgeneGRB7C1257931Mammary Neoplasms, Human2CTD_human
HgeneGRB7C1458155Mammary Neoplasms2CTD_human
HgeneGRB7C4704874Mammary Carcinoma, Human2CTD_human
HgeneGRB7C0001418Adenocarcinoma1CTD_human
HgeneGRB7C0007134Renal Cell Carcinoma1CTD_human
HgeneGRB7C0024121Lung Neoplasms1CTD_human
HgeneGRB7C0033578Prostatic Neoplasms1CTD_human
HgeneGRB7C0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneGRB7C0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneGRB7C0205643Carcinoma, Cribriform1CTD_human
HgeneGRB7C0205644Carcinoma, Granular Cell1CTD_human
HgeneGRB7C0205645Adenocarcinoma, Tubular1CTD_human
HgeneGRB7C0242379Malignant neoplasm of lung1CTD_human
HgeneGRB7C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneGRB7C0376358Malignant neoplasm of prostate1CTD_human
HgeneGRB7C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneGRB7C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneGRB7C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneGRB7C1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneITGB3C0040015Thrombasthenia29CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneITGB3C1861195Glanzmann Thrombasthenia, Autosomal Dominant4CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneITGB3C0004352Autistic Disorder3CTD_human
TgeneITGB3C3853779Neonatal Alloimmune Thrombocytopenia3CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneITGB3C3179396Glanzmann Thrombasthenia, Type A2CTD_human
TgeneITGB3C4304021Autosomal dominant macrothrombocytopenia2ORPHANET
TgeneITGB3C0007274Carotid Artery Thrombosis1CTD_human
TgeneITGB3C0010072Coronary Thrombosis1CTD_human
TgeneITGB3C0017639Gliosis1CTD_human
TgeneITGB3C0019080Hemorrhage1CTD_human
TgeneITGB3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneITGB3C0027051Myocardial Infarction1CTD_human
TgeneITGB3C0033578Prostatic Neoplasms1CTD_human
TgeneITGB3C0036341Schizophrenia1PSYGENET
TgeneITGB3C0038454Cerebrovascular accident1CTD_human
TgeneITGB3C0040034Thrombocytopenia1CTD_human
TgeneITGB3C0376358Malignant neoplasm of prostate1CTD_human
TgeneITGB3C0750988Common Carotid Artery Thrombosis1CTD_human
TgeneITGB3C0750989External Carotid Artery Thrombosis1CTD_human
TgeneITGB3C0750990Internal Carotid Artery Thrombosis1CTD_human
TgeneITGB3C0751956Acute Cerebrovascular Accidents1CTD_human
TgeneITGB3C0948089Acute Coronary Syndrome1CTD_human
TgeneITGB3C1510586Autism Spectrum Disorders1CTD_human
TgeneITGB3C2937358Cerebral Hemorrhage1CTD_human
TgeneITGB3C3854603FNAITP1ORPHANET
TgeneITGB3C3887640Astrocytosis1CTD_human