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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GRB7-KRT25 (FusionGDB2 ID:34543)

Fusion Gene Summary for GRB7-KRT25

Fusion gene summary

Fusion gene information	Fusion gene name: GRB7-KRT25
	Fusion gene ID: 34543
		Hgene	Tgene
	Gene symbol	GRB7	KRT25
	Gene ID	2886	147183
	Gene name	growth factor receptor bound protein 7	keratin 25
	Synonyms	-	ARWH3\|KRT24IRS1\|KRT25A
	Cytomap	17q12	17q21.2
	Type of gene	protein-coding	protein-coding
	Description	growth factor receptor-bound protein 7B47GRB7 adapter proteinepidermal growth factor receptor GRB-7	keratin, type I cytoskeletal 25CK-25K25K25Acytokeratin-25keratin 25, type Ikeratin-25Atype I inner root sheath specific keratin 25 irs1type I inner root sheath-specific keratin-K25irs1
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000309156, ENST00000309185, ENST00000394211, ENST00000578702, ENST00000445327, ENST00000394209, ENST00000394204,	ENST00000312150,
Fusion gene scores	* DoF score	23 X 20 X 8=3680	2 X 2 X 2=8
	# samples	42	3
	** MAII score	log2(42/3680*10)=-3.13124453327825 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/8*10)=1.90689059560852
Context	PubMed: GRB7 [Title/Abstract] AND KRT25 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GRB7(37900916)-KRT25(38906849), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GRB7	GO:0030335	positive regulation of cell migration	10893408\|12021278
Tgene	KRT25	GO:0007010	cytoskeleton organization	26902920
Tgene	KRT25	GO:0007568	aging	21916889
Tgene	KRT25	GO:0042633	hair cycle	21916889

Fusion gene breakpoints across GRB7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KRT25 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-D7-8573	GRB7	chr17	37900916	+	KRT25	chr17	38906849	-

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Fusion Gene ORF analysis for GRB7-KRT25

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000309156	ENST00000312150	GRB7	chr17	37900916	+	KRT25	chr17	38906849	-
In-frame	ENST00000309185	ENST00000312150	GRB7	chr17	37900916	+	KRT25	chr17	38906849	-
In-frame	ENST00000394211	ENST00000312150	GRB7	chr17	37900916	+	KRT25	chr17	38906849	-
intron-3CDS	ENST00000578702	ENST00000312150	GRB7	chr17	37900916	+	KRT25	chr17	38906849	-
In-frame	ENST00000445327	ENST00000312150	GRB7	chr17	37900916	+	KRT25	chr17	38906849	-
In-frame	ENST00000394209	ENST00000312150	GRB7	chr17	37900916	+	KRT25	chr17	38906849	-
In-frame	ENST00000394204	ENST00000312150	GRB7	chr17	37900916	+	KRT25	chr17	38906849	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000309156	GRB7	chr17	37900916	+	ENST00000312150	KRT25	chr17	38906849	-	1821	1169	257	1564	435
ENST00000309185	GRB7	chr17	37900916	+	ENST00000312150	KRT25	chr17	38906849	-	1814	1162	250	1557	435
ENST00000394211	GRB7	chr17	37900916	+	ENST00000312150	KRT25	chr17	38906849	-	1670	1018	106	1413	435
ENST00000445327	GRB7	chr17	37900916	+	ENST00000312150	KRT25	chr17	38906849	-	1768	1116	6	1511	501
ENST00000394209	GRB7	chr17	37900916	+	ENST00000312150	KRT25	chr17	38906849	-	1829	1177	106	1572	488
ENST00000394204	GRB7	chr17	37900916	+	ENST00000312150	KRT25	chr17	38906849	-	1614	962	50	1357	435

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000309156	ENST00000312150	GRB7	chr17	37900916	+	KRT25	chr17	38906849	-	0.00544693	0.9945531
ENST00000309185	ENST00000312150	GRB7	chr17	37900916	+	KRT25	chr17	38906849	-	0.005692391	0.9943076
ENST00000394211	ENST00000312150	GRB7	chr17	37900916	+	KRT25	chr17	38906849	-	0.006671879	0.9933281
ENST00000445327	ENST00000312150	GRB7	chr17	37900916	+	KRT25	chr17	38906849	-	0.012016078	0.98798394
ENST00000394209	ENST00000312150	GRB7	chr17	37900916	+	KRT25	chr17	38906849	-	0.006081412	0.99391854
ENST00000394204	ENST00000312150	GRB7	chr17	37900916	+	KRT25	chr17	38906849	-	0.007153022	0.992847

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Fusion Genomic Features for GRB7-KRT25

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRB7-KRT25

Go to
FGviewer for the breakpoints of chr17:37900916-chr17:38906849
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000309156

100_186

304.0

533.0

Domain

Ras-associating

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000309185

100_186

304.0

558.6666666666666

Domain

Ras-associating

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000394204

100_186

304.0

464.0

Domain

Ras-associating

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000394209

100_186

304.0

533.0

Domain

Ras-associating

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000394211

100_186

304.0

533.0

Domain

Ras-associating

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000445327

100_186

327.0

556.0

Domain

Ras-associating

Tgene

KRT25

chr17:37900916

chr17:38906849

ENST00000312150

391_450

319.0

451.0

Region

Tail

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000309156

229_338

304.0

533.0

Domain

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000309156

431_527

304.0

533.0

Domain

SH2

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000309185

229_338

304.0

558.6666666666666

Domain

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000309185

431_527

304.0

558.6666666666666

Domain

SH2

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000394204

229_338

304.0

464.0

Domain

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000394204

431_527

304.0

464.0

Domain

SH2

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000394209

229_338

304.0

533.0

Domain

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000394209

431_527

304.0

533.0

Domain

SH2

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000394211

229_338

304.0

533.0

Domain

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000394211

431_527

304.0

533.0

Domain

SH2

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000445327

229_338

327.0

556.0

Domain

Hgene

GRB7

chr17:37900916

chr17:38906849

ENST00000445327

431_527

327.0

556.0

Domain

SH2

Tgene

KRT25

chr17:37900916

chr17:38906849

ENST00000312150

25_77

319.0

451.0

Compositional bias

Gly-rich

Tgene

KRT25

chr17:37900916

chr17:38906849

ENST00000312150

79_394

319.0

451.0

Domain

IF rod

Tgene

KRT25

chr17:37900916

chr17:38906849

ENST00000312150

115_136

319.0

451.0

Region

Linker 1

Tgene

KRT25

chr17:37900916

chr17:38906849

ENST00000312150

137_228

319.0

451.0

Region

Coil 1B

Tgene

KRT25

chr17:37900916

chr17:38906849

ENST00000312150

1_78

319.0

451.0

Region

Head

Tgene

KRT25

chr17:37900916

chr17:38906849

ENST00000312150

229_251

319.0

451.0

Region

Linker 12

Tgene

KRT25

chr17:37900916

chr17:38906849

ENST00000312150

252_390

319.0

451.0

Region

Coil 2

Tgene

KRT25

chr17:37900916

chr17:38906849

ENST00000312150

79_114

319.0

451.0

Region

Coil 1A

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Fusion Gene Sequence for GRB7-KRT25

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000309156_ENST00000312150_TCGA-D7-8573_GRB7_chr17_37900916_+_KRT25_chr17_38906849_length(transcript)=1821nt_BP=1169nt
AAGATAATTTTAGTTTCCTTGGGCCTGGAATCTGGACACACAGGGCTCCCCCCCGCCTCTGACTTCTCTGTCCGAAGTCGGGACACCCTC
CTACCACCTGTAGAGAAGCGGGAGTGGATCTGAAATAAAATCCAGGAATCTGGGGGTTCCTAGACGGAGCCAGACTTCGGAACGGGTGTC
CTGCTACTCCTGCTGGGGCTCCTCCAGGACAAGGGCACACAACTGGTTCCGTTAAGCCCCTCTCTTGCTCAGACGCCATGGAGCTGGATC
TGTCTCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTC
TGCCTGAGGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCGAGAGGAGGAGAGGCGTGCCACCTCCCTCC
CCTCTATCCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCTCCAGTGCAAGGGGGCTGCTCC
CCCGCGATGCCAGCCGCCCCCATGTAGTAAAGGTGTACAGTGAGGATGGGGCCTGCAGGTCTGTGGAGGTGGCAGCAGGTGCCACAGCTC
GCCACGTGTGTGAAATGCTGGTGCAGCGAGCTCACGCCTTGAGCGACGAGACCTGGGGGCTGGTGGAGTGCCACCCCCACCTAGCACTGG
AGCGGGGTTTGGAGGACCACGAGTCCGTGGTGGAAGTGCAGGCTGCCTGGCCCGTGGGCGGAGATAGCCGCTTCGTCTTCCGGAAAAACT
TCGCCAAGTACGAACTGTTCAAGAGCTCCCCACACTCCCTGTTCCCAGAAAAAATGGTCTCCAGCTGTCTCGATGCACACACTGGTATAT
CCCATGAAGACCTCATCCAGAACTTCCTGAATGCTGGCAGCTTTCCTGAGATCCAGGGCTTTCTGCAGCTGCGGGGTTCAGGACGGAAGC
TTTGGAAACGCTTTTTCTGCTTCTTGCGCCGATCTGGCCTCTATTACTCCACCAAGGGCACCTCTAAGGATCCGAGGCACCTGCAGTACG
TGGCAGATGTGAACGAGTCCAACGTGTACGTGGTGACGCAGGGCCGCAAGCTCTACGGGATGCCCACTGACTTCGGTTTCTGTGTCAAGA
AACACTCCCTGGAGTGCTCCTTGACAGAGACCGAGAGCAACTACTGTGCGCAGCTGGCGCAGATCCAGGCTCAGATCGGGGCCCTGGAGG
AGCAGCTGCACCAGGTCAGAACCGAGACCGAGGGCCAGAAGCTGGAGTATGAGCAGCTCCTGGACATCAAGCTCCACCTGGAAAAAGAAA
TTGAGACCTACTGTCTCCTTATAGGAGGAGATGATGGAGCCTGTAAGTCTGGGGGTTACAAGTCTAAAGATTATGGATCTGGAAATGTGG
GAAGTCAAGTCAAAGACCCAGCCAAAGCCATAGTGGTTAAGAAAGTTCTTGAGGAGGTAGACCAACGCAGCAAAATACTTACCACCAGGC
TCCACTCCCTGGAAGAGAAATCTCAAAGCAATTAATTTGAGATGCAACAGAGAACGTATGCCACATAGCCCCTGCGAAGAAAAGGCATTA
TGTATCTGTCCAGAAAAATGTGCATGTCTAAGAAAAATGTCTAACCTGTTGTCTTTCTGTTACTTTCTTTCTGGGCAATCAATGACAGCA
TCTCCCCATTCATCTAGAAGAATGCCACACACAAATATGACTCATTTGATTATCCTACAGAAATCTGTTGTCAATTCTTTGTATTCAATA

>In-frame_ENST00000309156_ENST00000312150_TCGA-D7-8573_GRB7_chr17_37900916_+_KRT25_chr17_38906849_length(amino acids)=435AA_start in transcript=257_stop in transcript=1564
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSA
RGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPR
HLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKKHSLECSLTETESNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKLH

--------------------------------------------------------------
>In-frame_ENST00000309185_ENST00000312150_TCGA-D7-8573_GRB7_chr17_37900916_+_KRT25_chr17_38906849_length(transcript)=1814nt_BP=1162nt
TTTTAGTTTCCTTGGGCCTGGAATCTGGACACACAGGGCTCCCCCCCGCCTCTGACTTCTCTGTCCGAAGTCGGGACACCCTCCTACCAC
CTGTAGAGAAGCGGGAGTGGATCTGAAATAAAATCCAGGAATCTGGGGGTTCCTAGACGGAGCCAGACTTCGGAACGGGTGTCCTGCTAC
TCCTGCTGGGGCTCCTCCAGGACAAGGGCACACAACTGGTTCCGTTAAGCCCCTCTCTTGCTCAGACGCCATGGAGCTGGATCTGTCTCC
ACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGA
GGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCGAGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTAT
CCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCTCCAGTGCAAGGGGGCTGCTCCCCCGCGA
TGCCAGCCGCCCCCATGTAGTAAAGGTGTACAGTGAGGATGGGGCCTGCAGGTCTGTGGAGGTGGCAGCAGGTGCCACAGCTCGCCACGT
GTGTGAAATGCTGGTGCAGCGAGCTCACGCCTTGAGCGACGAGACCTGGGGGCTGGTGGAGTGCCACCCCCACCTAGCACTGGAGCGGGG
TTTGGAGGACCACGAGTCCGTGGTGGAAGTGCAGGCTGCCTGGCCCGTGGGCGGAGATAGCCGCTTCGTCTTCCGGAAAAACTTCGCCAA
GTACGAACTGTTCAAGAGCTCCCCACACTCCCTGTTCCCAGAAAAAATGGTCTCCAGCTGTCTCGATGCACACACTGGTATATCCCATGA
AGACCTCATCCAGAACTTCCTGAATGCTGGCAGCTTTCCTGAGATCCAGGGCTTTCTGCAGCTGCGGGGTTCAGGACGGAAGCTTTGGAA
ACGCTTTTTCTGCTTCTTGCGCCGATCTGGCCTCTATTACTCCACCAAGGGCACCTCTAAGGATCCGAGGCACCTGCAGTACGTGGCAGA
TGTGAACGAGTCCAACGTGTACGTGGTGACGCAGGGCCGCAAGCTCTACGGGATGCCCACTGACTTCGGTTTCTGTGTCAAGAAACACTC
CCTGGAGTGCTCCTTGACAGAGACCGAGAGCAACTACTGTGCGCAGCTGGCGCAGATCCAGGCTCAGATCGGGGCCCTGGAGGAGCAGCT
GCACCAGGTCAGAACCGAGACCGAGGGCCAGAAGCTGGAGTATGAGCAGCTCCTGGACATCAAGCTCCACCTGGAAAAAGAAATTGAGAC
CTACTGTCTCCTTATAGGAGGAGATGATGGAGCCTGTAAGTCTGGGGGTTACAAGTCTAAAGATTATGGATCTGGAAATGTGGGAAGTCA
AGTCAAAGACCCAGCCAAAGCCATAGTGGTTAAGAAAGTTCTTGAGGAGGTAGACCAACGCAGCAAAATACTTACCACCAGGCTCCACTC
CCTGGAAGAGAAATCTCAAAGCAATTAATTTGAGATGCAACAGAGAACGTATGCCACATAGCCCCTGCGAAGAAAAGGCATTATGTATCT
GTCCAGAAAAATGTGCATGTCTAAGAAAAATGTCTAACCTGTTGTCTTTCTGTTACTTTCTTTCTGGGCAATCAATGACAGCATCTCCCC
ATTCATCTAGAAGAATGCCACACACAAATATGACTCATTTGATTATCCTACAGAAATCTGTTGTCAATTCTTTGTATTCAATAAACCTCT

>In-frame_ENST00000309185_ENST00000312150_TCGA-D7-8573_GRB7_chr17_37900916_+_KRT25_chr17_38906849_length(amino acids)=435AA_start in transcript=250_stop in transcript=1557
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSA
RGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPR
HLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKKHSLECSLTETESNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKLH

--------------------------------------------------------------
>In-frame_ENST00000394211_ENST00000312150_TCGA-D7-8573_GRB7_chr17_37900916_+_KRT25_chr17_38906849_length(transcript)=1670nt_BP=1018nt
CGTCTCCCTCCCTGAAGACGTGGTCCCAGCCGGGTGTCCTGACGCTCGGGGTTCAGGACAAGGGCACACAACTGGTTCCGTTAAGCCCCT
CTCTTGCTCAGACGCCATGGAGCTGGATCTGTCTCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCC
TGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGAGGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCG
AGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTATCCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGG
GGGCCCCTCCAGTGCAAGGGGGCTGCTCCCCCGCGATGCCAGCCGCCCCCATGTAGTAAAGGTGTACAGTGAGGATGGGGCCTGCAGGTC
TGTGGAGGTGGCAGCAGGTGCCACAGCTCGCCACGTGTGTGAAATGCTGGTGCAGCGAGCTCACGCCTTGAGCGACGAGACCTGGGGGCT
GGTGGAGTGCCACCCCCACCTAGCACTGGAGCGGGGTTTGGAGGACCACGAGTCCGTGGTGGAAGTGCAGGCTGCCTGGCCCGTGGGCGG
AGATAGCCGCTTCGTCTTCCGGAAAAACTTCGCCAAGTACGAACTGTTCAAGAGCTCCCCACACTCCCTGTTCCCAGAAAAAATGGTCTC
CAGCTGTCTCGATGCACACACTGGTATATCCCATGAAGACCTCATCCAGAACTTCCTGAATGCTGGCAGCTTTCCTGAGATCCAGGGCTT
TCTGCAGCTGCGGGGTTCAGGACGGAAGCTTTGGAAACGCTTTTTCTGCTTCTTGCGCCGATCTGGCCTCTATTACTCCACCAAGGGCAC
CTCTAAGGATCCGAGGCACCTGCAGTACGTGGCAGATGTGAACGAGTCCAACGTGTACGTGGTGACGCAGGGCCGCAAGCTCTACGGGAT
GCCCACTGACTTCGGTTTCTGTGTCAAGAAACACTCCCTGGAGTGCTCCTTGACAGAGACCGAGAGCAACTACTGTGCGCAGCTGGCGCA
GATCCAGGCTCAGATCGGGGCCCTGGAGGAGCAGCTGCACCAGGTCAGAACCGAGACCGAGGGCCAGAAGCTGGAGTATGAGCAGCTCCT
GGACATCAAGCTCCACCTGGAAAAAGAAATTGAGACCTACTGTCTCCTTATAGGAGGAGATGATGGAGCCTGTAAGTCTGGGGGTTACAA
GTCTAAAGATTATGGATCTGGAAATGTGGGAAGTCAAGTCAAAGACCCAGCCAAAGCCATAGTGGTTAAGAAAGTTCTTGAGGAGGTAGA
CCAACGCAGCAAAATACTTACCACCAGGCTCCACTCCCTGGAAGAGAAATCTCAAAGCAATTAATTTGAGATGCAACAGAGAACGTATGC
CACATAGCCCCTGCGAAGAAAAGGCATTATGTATCTGTCCAGAAAAATGTGCATGTCTAAGAAAAATGTCTAACCTGTTGTCTTTCTGTT
ACTTTCTTTCTGGGCAATCAATGACAGCATCTCCCCATTCATCTAGAAGAATGCCACACACAAATATGACTCATTTGATTATCCTACAGA

>In-frame_ENST00000394211_ENST00000312150_TCGA-D7-8573_GRB7_chr17_37900916_+_KRT25_chr17_38906849_length(amino acids)=435AA_start in transcript=106_stop in transcript=1413
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSA
RGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPR
HLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKKHSLECSLTETESNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKLH

--------------------------------------------------------------
>In-frame_ENST00000445327_ENST00000312150_TCGA-D7-8573_GRB7_chr17_37900916_+_KRT25_chr17_38906849_length(transcript)=1768nt_BP=1116nt
TGCGGGCTGCGGGGAGATGTGGGGAGGGCCCCCTCCACTTTGGAGGGCAGTGAAGGAGAGGGATCCTCTAAATTGTCGAGGCTTCATCTC
TCCAGATTGTATGCCCTTCTCAGCAACACCGCCTCCGGCCCTCCGATGGGAAAGTGGAGGCCGGGACAAGGGCACACAACTGGTTCCGTT
AAGCCCCTCTCTTGCTCAGACGCCATGGAGCTGGATCTGTCTCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGG
ACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGAGGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGG
AAACTTCGAGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTATCCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCA
ATTCTCGGGGGCCCCTCCAGTGCAAGGGGGCTGCTCCCCCGCGATGCCAGCCGCCCCCATGTAGTAAAGGTGTACAGTGAGGATGGGGCC
TGCAGGTCTGTGGAGGTGGCAGCAGGTGCCACAGCTCGCCACGTGTGTGAAATGCTGGTGCAGCGAGCTCACGCCTTGAGCGACGAGACC
TGGGGGCTGGTGGAGTGCCACCCCCACCTAGCACTGGAGCGGGGTTTGGAGGACCACGAGTCCGTGGTGGAAGTGCAGGCTGCCTGGCCC
GTGGGCGGAGATAGCCGCTTCGTCTTCCGGAAAAACTTCGCCAAGTACGAACTGTTCAAGAGCTCCCCACACTCCCTGTTCCCAGAAAAA
ATGGTCTCCAGCTGTCTCGATGCACACACTGGTATATCCCATGAAGACCTCATCCAGAACTTCCTGAATGCTGGCAGCTTTCCTGAGATC
CAGGGCTTTCTGCAGCTGCGGGGTTCAGGACGGAAGCTTTGGAAACGCTTTTTCTGCTTCTTGCGCCGATCTGGCCTCTATTACTCCACC
AAGGGCACCTCTAAGGATCCGAGGCACCTGCAGTACGTGGCAGATGTGAACGAGTCCAACGTGTACGTGGTGACGCAGGGCCGCAAGCTC
TACGGGATGCCCACTGACTTCGGTTTCTGTGTCAAGAAACACTCCCTGGAGTGCTCCTTGACAGAGACCGAGAGCAACTACTGTGCGCAG
CTGGCGCAGATCCAGGCTCAGATCGGGGCCCTGGAGGAGCAGCTGCACCAGGTCAGAACCGAGACCGAGGGCCAGAAGCTGGAGTATGAG
CAGCTCCTGGACATCAAGCTCCACCTGGAAAAAGAAATTGAGACCTACTGTCTCCTTATAGGAGGAGATGATGGAGCCTGTAAGTCTGGG
GGTTACAAGTCTAAAGATTATGGATCTGGAAATGTGGGAAGTCAAGTCAAAGACCCAGCCAAAGCCATAGTGGTTAAGAAAGTTCTTGAG
GAGGTAGACCAACGCAGCAAAATACTTACCACCAGGCTCCACTCCCTGGAAGAGAAATCTCAAAGCAATTAATTTGAGATGCAACAGAGA
ACGTATGCCACATAGCCCCTGCGAAGAAAAGGCATTATGTATCTGTCCAGAAAAATGTGCATGTCTAAGAAAAATGTCTAACCTGTTGTC
TTTCTGTTACTTTCTTTCTGGGCAATCAATGACAGCATCTCCCCATTCATCTAGAAGAATGCCACACACAAATATGACTCATTTGATTAT

>In-frame_ENST00000445327_ENST00000312150_TCGA-D7-8573_GRB7_chr17_37900916_+_KRT25_chr17_38906849_length(amino acids)=501AA_start in transcript=6_stop in transcript=1511
MRGDVGRAPSTLEGSEGEGSSKLSRLHLSRLYALLSNTASGPPMGKWRPGQGHTTGSVKPLSCSDAMELDLSPPHLSSSPEDLCPAPGTP
PGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACR
SVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMV
SSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYG
MPTDFGFCVKKHSLECSLTETESNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKLHLEKEIETYCLLIGGDDGACKSGGY

--------------------------------------------------------------
>In-frame_ENST00000394209_ENST00000312150_TCGA-D7-8573_GRB7_chr17_37900916_+_KRT25_chr17_38906849_length(transcript)=1829nt_BP=1177nt
AGGCAAACCCCAGCCTTGGACTGGCCCTCTCTGATCTCTGAGGCCAGGCTCTAATGTGATTTGAATCTACTTCTAACCCCTTCCAAGCAC
TGCCCTCCCGAATTCTCTGCTCCTCTCCCCACCCCACTGTTGGTCTGTGATTTCGAGGCAGGCGTGGCCCCCTGCAGCCTGGAATGAAGT
CACTGGGGCTGTTTGGAGACCGGGGCTGTTTGGAGGACAAGGGCACACAACTGGTTCCGTTAAGCCCCTCTCTTGCTCAGACGCCATGGA
GCTGGATCTGTCTCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCCTGGGACTCCCCGGCCCCCTGA
TACCCCTCTGCCTGAGGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCGAGAGGAGGAGAGGCGTGCCAC
CTCCCTCCCCTCTATCCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCTCCAGTGCAAGGGG
GCTGCTCCCCCGCGATGCCAGCCGCCCCCATGTAGTAAAGGTGTACAGTGAGGATGGGGCCTGCAGGTCTGTGGAGGTGGCAGCAGGTGC
CACAGCTCGCCACGTGTGTGAAATGCTGGTGCAGCGAGCTCACGCCTTGAGCGACGAGACCTGGGGGCTGGTGGAGTGCCACCCCCACCT
AGCACTGGAGCGGGGTTTGGAGGACCACGAGTCCGTGGTGGAAGTGCAGGCTGCCTGGCCCGTGGGCGGAGATAGCCGCTTCGTCTTCCG
GAAAAACTTCGCCAAGTACGAACTGTTCAAGAGCTCCCCACACTCCCTGTTCCCAGAAAAAATGGTCTCCAGCTGTCTCGATGCACACAC
TGGTATATCCCATGAAGACCTCATCCAGAACTTCCTGAATGCTGGCAGCTTTCCTGAGATCCAGGGCTTTCTGCAGCTGCGGGGTTCAGG
ACGGAAGCTTTGGAAACGCTTTTTCTGCTTCTTGCGCCGATCTGGCCTCTATTACTCCACCAAGGGCACCTCTAAGGATCCGAGGCACCT
GCAGTACGTGGCAGATGTGAACGAGTCCAACGTGTACGTGGTGACGCAGGGCCGCAAGCTCTACGGGATGCCCACTGACTTCGGTTTCTG
TGTCAAGAAACACTCCCTGGAGTGCTCCTTGACAGAGACCGAGAGCAACTACTGTGCGCAGCTGGCGCAGATCCAGGCTCAGATCGGGGC
CCTGGAGGAGCAGCTGCACCAGGTCAGAACCGAGACCGAGGGCCAGAAGCTGGAGTATGAGCAGCTCCTGGACATCAAGCTCCACCTGGA
AAAAGAAATTGAGACCTACTGTCTCCTTATAGGAGGAGATGATGGAGCCTGTAAGTCTGGGGGTTACAAGTCTAAAGATTATGGATCTGG
AAATGTGGGAAGTCAAGTCAAAGACCCAGCCAAAGCCATAGTGGTTAAGAAAGTTCTTGAGGAGGTAGACCAACGCAGCAAAATACTTAC
CACCAGGCTCCACTCCCTGGAAGAGAAATCTCAAAGCAATTAATTTGAGATGCAACAGAGAACGTATGCCACATAGCCCCTGCGAAGAAA
AGGCATTATGTATCTGTCCAGAAAAATGTGCATGTCTAAGAAAAATGTCTAACCTGTTGTCTTTCTGTTACTTTCTTTCTGGGCAATCAA
TGACAGCATCTCCCCATTCATCTAGAAGAATGCCACACACAAATATGACTCATTTGATTATCCTACAGAAATCTGTTGTCAATTCTTTGT

>In-frame_ENST00000394209_ENST00000312150_TCGA-D7-8573_GRB7_chr17_37900916_+_KRT25_chr17_38906849_length(amino acids)=488AA_start in transcript=106_stop in transcript=1572
MLLSPPHCWSVISRQAWPPAAWNEVTGAVWRPGLFGGQGHTTGSVKPLSCSDAMELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPE
EVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHV
CEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHE
DLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKKHS
LECSLTETESNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKLHLEKEIETYCLLIGGDDGACKSGGYKSKDYGSGNVGSQ

--------------------------------------------------------------
>In-frame_ENST00000394204_ENST00000312150_TCGA-D7-8573_GRB7_chr17_37900916_+_KRT25_chr17_38906849_length(transcript)=1614nt_BP=962nt
GACAAGGGCACACAACTGGTTCCGTTAAGCCCCTCTCTTGCTCAGACGCCATGGAGCTGGATCTGTCTCCACCTCATCTTAGCAGCTCTC
CGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGAGGAGGTAAAGAGGTCCCAGC
CTCTCCTCATCCCAACCACCGGCAGGAAACTTCGAGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTATCCCCAACCCCTTCCCTGAGC
TCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCTCCAGTGCAAGGGGGCTGCTCCCCCGCGATGCCAGCCGCCCCCATGTAG
TAAAGGTGTACAGTGAGGATGGGGCCTGCAGGTCTGTGGAGGTGGCAGCAGGTGCCACAGCTCGCCACGTGTGTGAAATGCTGGTGCAGC
GAGCTCACGCCTTGAGCGACGAGACCTGGGGGCTGGTGGAGTGCCACCCCCACCTAGCACTGGAGCGGGGTTTGGAGGACCACGAGTCCG
TGGTGGAAGTGCAGGCTGCCTGGCCCGTGGGCGGAGATAGCCGCTTCGTCTTCCGGAAAAACTTCGCCAAGTACGAACTGTTCAAGAGCT
CCCCACACTCCCTGTTCCCAGAAAAAATGGTCTCCAGCTGTCTCGATGCACACACTGGTATATCCCATGAAGACCTCATCCAGAACTTCC
TGAATGCTGGCAGCTTTCCTGAGATCCAGGGCTTTCTGCAGCTGCGGGGTTCAGGACGGAAGCTTTGGAAACGCTTTTTCTGCTTCTTGC
GCCGATCTGGCCTCTATTACTCCACCAAGGGCACCTCTAAGGATCCGAGGCACCTGCAGTACGTGGCAGATGTGAACGAGTCCAACGTGT
ACGTGGTGACGCAGGGCCGCAAGCTCTACGGGATGCCCACTGACTTCGGTTTCTGTGTCAAGAAACACTCCCTGGAGTGCTCCTTGACAG
AGACCGAGAGCAACTACTGTGCGCAGCTGGCGCAGATCCAGGCTCAGATCGGGGCCCTGGAGGAGCAGCTGCACCAGGTCAGAACCGAGA
CCGAGGGCCAGAAGCTGGAGTATGAGCAGCTCCTGGACATCAAGCTCCACCTGGAAAAAGAAATTGAGACCTACTGTCTCCTTATAGGAG
GAGATGATGGAGCCTGTAAGTCTGGGGGTTACAAGTCTAAAGATTATGGATCTGGAAATGTGGGAAGTCAAGTCAAAGACCCAGCCAAAG
CCATAGTGGTTAAGAAAGTTCTTGAGGAGGTAGACCAACGCAGCAAAATACTTACCACCAGGCTCCACTCCCTGGAAGAGAAATCTCAAA
GCAATTAATTTGAGATGCAACAGAGAACGTATGCCACATAGCCCCTGCGAAGAAAAGGCATTATGTATCTGTCCAGAAAAATGTGCATGT
CTAAGAAAAATGTCTAACCTGTTGTCTTTCTGTTACTTTCTTTCTGGGCAATCAATGACAGCATCTCCCCATTCATCTAGAAGAATGCCA

>In-frame_ENST00000394204_ENST00000312150_TCGA-D7-8573_GRB7_chr17_37900916_+_KRT25_chr17_38906849_length(amino acids)=435AA_start in transcript=50_stop in transcript=1357
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSA
RGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPR
HLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKKHSLECSLTETESNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKLH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GRB7-KRT25

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GRB7-KRT25

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GRB7-KRT25

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	GRB7	C0006142	Malignant neoplasm of breast	2	CTD_human
Hgene	GRB7	C0678222	Breast Carcinoma	2	CTD_human
Hgene	GRB7	C1257931	Mammary Neoplasms, Human	2	CTD_human
Hgene	GRB7	C1458155	Mammary Neoplasms	2	CTD_human
Hgene	GRB7	C4704874	Mammary Carcinoma, Human	2	CTD_human
Hgene	GRB7	C0001418	Adenocarcinoma	1	CTD_human
Hgene	GRB7	C0007134	Renal Cell Carcinoma	1	CTD_human
Hgene	GRB7	C0024121	Lung Neoplasms	1	CTD_human
Hgene	GRB7	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	GRB7	C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Hgene	GRB7	C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Hgene	GRB7	C0205643	Carcinoma, Cribriform	1	CTD_human
Hgene	GRB7	C0205644	Carcinoma, Granular Cell	1	CTD_human
Hgene	GRB7	C0205645	Adenocarcinoma, Tubular	1	CTD_human
Hgene	GRB7	C0242379	Malignant neoplasm of lung	1	CTD_human
Hgene	GRB7	C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	1	CTD_human
Hgene	GRB7	C0376358	Malignant neoplasm of prostate	1	CTD_human
Hgene	GRB7	C1266042	Chromophobe Renal Cell Carcinoma	1	CTD_human
Hgene	GRB7	C1266043	Sarcomatoid Renal Cell Carcinoma	1	CTD_human
Hgene	GRB7	C1266044	Collecting Duct Carcinoma of the Kidney	1	CTD_human
Hgene	GRB7	C1306837	Papillary Renal Cell Carcinoma	1	CTD_human
Tgene	KRT25	C4225214	WOOLLY HAIR, AUTOSOMAL RECESSIVE 3	3	GENOMICS_ENGLAND;UNIPROT
Tgene	KRT25	C0343073	Wooly hair	1	ORPHANET
Tgene	KRT25	C0345427	Woolly hair, congenital	1	ORPHANET