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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GRIK4-SESN1 (FusionGDB2 ID:34670)

Fusion Gene Summary for GRIK4-SESN1

check button Fusion gene summary
Fusion gene informationFusion gene name: GRIK4-SESN1
Fusion gene ID: 34670
HgeneTgene
Gene symbol

GRIK4

SESN1

Gene ID

2900

27244

Gene nameglutamate ionotropic receptor kainate type subunit 4sestrin 1
SynonymsEAA1|GRIK|GluK4|KA1PA26|SEST1
Cytomap

11q23.3

6q21

Type of geneprotein-codingprotein-coding
Descriptionglutamate receptor ionotropic, kainate 4excitatory amino acid receptor 1glutamate receptor KA1glutamate receptor, ionotropic, kainate 4sestrin-1p53 activated gene 26p53 regulated PA26 nuclear protein
Modification date2020032020200313
UniProtAcc

Q16099

.
Ensembl transtripts involved in fusion geneENST00000527524, ENST00000438375, 
ENST00000527130, 		ENST00000436639, 
ENST00000302071, ENST00000356644, 
ENST00000517548, 
Fusion gene scores* DoF score6 X 6 X 5=1806 X 6 X 3=108
# samples 66
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRIK4 [Title/Abstract] AND SESN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGRIK4(120745952)-SESN1(109323546), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GRIK4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SESN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-04-1514-01AGRIK4chr11

120745952

+SESN1chr6

109323546

-
ChimerDB4OVTCGA-04-1514-01AGRIK4chr11

120745952

+SESN1chr6

109323546

-


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Fusion Gene ORF analysis for GRIK4-SESN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000527524ENST00000436639GRIK4chr11

120745952

+SESN1chr6

109323546

-
5CDS-5UTRENST00000527524ENST00000302071GRIK4chr11

120745952

+SESN1chr6

109323546

-
5CDS-5UTRENST00000527524ENST00000356644GRIK4chr11

120745952

+SESN1chr6

109323546

-
5CDS-intronENST00000527524ENST00000517548GRIK4chr11

120745952

+SESN1chr6

109323546

-
In-frameENST00000438375ENST00000436639GRIK4chr11

120745952

+SESN1chr6

109323546

-
5CDS-5UTRENST00000438375ENST00000302071GRIK4chr11

120745952

+SESN1chr6

109323546

-
5CDS-5UTRENST00000438375ENST00000356644GRIK4chr11

120745952

+SESN1chr6

109323546

-
5CDS-intronENST00000438375ENST00000517548GRIK4chr11

120745952

+SESN1chr6

109323546

-
intron-3CDSENST00000527130ENST00000436639GRIK4chr11

120745952

+SESN1chr6

109323546

-
intron-5UTRENST00000527130ENST00000302071GRIK4chr11

120745952

+SESN1chr6

109323546

-
intron-5UTRENST00000527130ENST00000356644GRIK4chr11

120745952

+SESN1chr6

109323546

-
intron-intronENST00000527130ENST00000517548GRIK4chr11

120745952

+SESN1chr6

109323546

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000527524GRIK4chr11120745952+ENST00000436639SESN1chr6109323546-393514512872827846
ENST00000438375GRIK4chr11120745952+ENST00000436639SESN1chr6109323546-399015063422882846

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000527524ENST00000436639GRIK4chr11120745952+SESN1chr6109323546-0.0009022790.9990977
ENST00000438375ENST00000436639GRIK4chr11120745952+SESN1chr6109323546-0.000737710.9992623

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Fusion Genomic Features for GRIK4-SESN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRIK4-SESN1


check button Go to

FGviewer for the breakpoints of chr11:120745952-chr6:109323546

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRIK4

Q16099

.
FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSESN1chr11:120745952chr6:109323546ENST00000302071010321_4920427.0RegionC-terminal domain%3B mediates TORC1 regulation
TgeneSESN1chr11:120745952chr6:109323546ENST00000302071010386_3890427.0RegionLeucine-binding
TgeneSESN1chr11:120745952chr6:109323546ENST0000030207101071_2520427.0RegionN-terminal domain%3B mediates the alkylhydroperoxide reductase activity
TgeneSESN1chr11:120745952chr6:109323546ENST00000356644010321_49234.0493.0RegionC-terminal domain%3B mediates TORC1 regulation
TgeneSESN1chr11:120745952chr6:109323546ENST00000356644010386_38934.0493.0RegionLeucine-binding
TgeneSESN1chr11:120745952chr6:109323546ENST0000035664401071_25234.0493.0RegionN-terminal domain%3B mediates the alkylhydroperoxide reductase activity
TgeneSESN1chr11:120745952chr6:109323546ENST00000436639010321_49293.0552.0RegionC-terminal domain%3B mediates TORC1 regulation
TgeneSESN1chr11:120745952chr6:109323546ENST00000436639010386_38993.0552.0RegionLeucine-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRIK4chr11:120745952chr6:109323546ENST00000438375+1020862_865388.0957.0Compositional biasNote=Poly-Arg
HgeneGRIK4chr11:120745952chr6:109323546ENST00000527524+1121862_865388.0957.0Compositional biasNote=Poly-Arg
HgeneGRIK4chr11:120745952chr6:109323546ENST00000438375+102021_545388.0957.0Topological domainExtracellular
HgeneGRIK4chr11:120745952chr6:109323546ENST00000438375+1020567_623388.0957.0Topological domainCytoplasmic
HgeneGRIK4chr11:120745952chr6:109323546ENST00000438375+1020645_804388.0957.0Topological domainExtracellular
HgeneGRIK4chr11:120745952chr6:109323546ENST00000438375+1020826_956388.0957.0Topological domainCytoplasmic
HgeneGRIK4chr11:120745952chr6:109323546ENST00000527524+112121_545388.0957.0Topological domainExtracellular
HgeneGRIK4chr11:120745952chr6:109323546ENST00000527524+1121567_623388.0957.0Topological domainCytoplasmic
HgeneGRIK4chr11:120745952chr6:109323546ENST00000527524+1121645_804388.0957.0Topological domainExtracellular
HgeneGRIK4chr11:120745952chr6:109323546ENST00000527524+1121826_956388.0957.0Topological domainCytoplasmic
HgeneGRIK4chr11:120745952chr6:109323546ENST00000438375+1020546_566388.0957.0TransmembraneHelical
HgeneGRIK4chr11:120745952chr6:109323546ENST00000438375+1020624_644388.0957.0TransmembraneHelical
HgeneGRIK4chr11:120745952chr6:109323546ENST00000438375+1020805_825388.0957.0TransmembraneHelical
HgeneGRIK4chr11:120745952chr6:109323546ENST00000527524+1121546_566388.0957.0TransmembraneHelical
HgeneGRIK4chr11:120745952chr6:109323546ENST00000527524+1121624_644388.0957.0TransmembraneHelical
HgeneGRIK4chr11:120745952chr6:109323546ENST00000527524+1121805_825388.0957.0TransmembraneHelical
TgeneSESN1chr11:120745952chr6:109323546ENST0000043663901071_25293.0552.0RegionN-terminal domain%3B mediates the alkylhydroperoxide reductase activity


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Fusion Gene Sequence for GRIK4-SESN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000527524_ENST00000436639_TCGA-04-1514-01A_GRIK4_chr11_120745952_+_SESN1_chr6_109323546_length(transcript)=3935nt_BP=1451nt
AGCTGCGGGCGGATCGGGCTGGAGCCGCCACGGCTGCTGCGGAAGAGGAAAAACGGCCAACAGCAGCCCCGCGGCCGGCCCGGCAGCGCC
CGGCCCCCGGCTCAGCCCCCGGAGTGCGGAGCCGACCAGCAGATACTTTCTGAGTGCCTACTATGTGCCAGCCTGTGCTAGGCACTGAGG
ACACAGGTGGAAAAGCCCGAATTGCTCCCTGCTCTCCTGGCGCTCATCACCCCGGAGAGTTATGTCATGCCCAGGCCAGCAGGGGGCTCC
ATGAGGATTCATAGAAGATGCCCCGCGTCTCGGCGCCTTTGGTGCTGCTTCCTGCGTGGCTCGTGATGGTCGCCTGCAGCCCGCACTCCT
TGAGGATCGCTGCTATCTTGGACGACCCCATGGAGTGCAGCAGAGGGGAGCGGCTCTCCATCACCCTGGCCAAGAACCGCATCAACCGCG
CTCCTGAGAGGCTGGGCAAGGCCAAGGTCGAAGTGGACATCTTTGAGCTTCTCAGAGACAGCGAGTACGAGACTGCAGAAACCATGTGTC
AGATCCTCCCCAAGGGGGTGGTCGCTGTCCTCGGACCATCGTCCAGCCCAGCCTCCAGCTCCATCATCAGCAACATCTGTGGAGAGAAGG
AGGTCCCTCACTTCAAAGTGGCCCCAGAGGAGTTCGTCAAGTTCCAGTTCCAGAGATTCACAACCCTGAACCTCCACCCCAGCAACACTG
ACATCAGCGTGGCTGTAGCTGGGATCCTGAACTTCTTCAACTGCACCACCGCCTGCCTCATCTGTGCCAAAGCAGAATGCCTTTTAAACC
TAGAGAAGCTGCTCCGGCAATTCCTTATCTCCAAGGACACGCTGTCCGTCCGCATGCTGGATGACACCCGGGACCCCACCCCGCTCCTCA
AGGAGATCCGGGACGACAAGACCGCCACCATCATCATCCACGCCAACGCCTCCATGTCCCACACCATCCTCCTGAAGGCAGCCGAACTTG
GGATGGTGTCAGCCTATTACACATACATCTTCACTAATCTGGAGTTCTCACTCCAGAGAATGGACAGCCTTGTGGATGATCGTGTCAACA
TCCTGGGATTTTCCATTTTCAACCAATCCCATGCTTTCTTCCAAGAGTTTGCCCAGAGCCTCAACCAGTCCTGGCAGGAGAACTGTGACC
ATGTGCCCTTCACTGGGCCTGCGCTCTCCTCGGCCCTGCTGTTTGATGCTGTCTATGCTGTGGTGACTGCGGTGCAGGAACTGAACCGGA
GCCAAGAGATCGGCGTGAAGCCCTTGTCCTGCGGCTCGGCCCAGATCTGGCAGCACGGCACCAGCCTCATGAACTACCTGCGCATGGTAG
AATTGGAAGGTCTTACCGGCCACATTGAATTCAACAGCAAAGGCCAGAGGTCCAACTACGCTTTGAAAATCTTACAGTTCACAAGGAATG
GTTTTCGGCAGGAACTTGGCATTAGAATTCCTCGACCACTAGGACAGGGACCAAGCAGATTCATCCCAGAAAAGGAGATCCTCCAAGTGG
GGAGTGAAGACGCACAGATGCATGCTTTATTTGCAGATTCTTTTGCTGCTTTGGGCCGTTTGGATAACATTACGTTAGTGATGGTTTTCC
ACCCACAATATTTAGAAAGTTTCTTAAAAACTCAGCACTATCTACTGCAAATGGATGGGCCGTTACCCCTACATTATCGTCACTACATTG
GAATAATGGCTGCGGCAAGACATCAGTGCTCCTACTTAGTGAACCTGCATGTAAATGATTTCCTTCATGTTGGTGGGGACCCCAAGTGGC
TCAATGGTTTAGAGAATGCTCCTCAAAAACTACAGAATTTAGGAGAACTTAACAAAGTGTTAGCCCATAGACCTTGGCTTATTACCAAAG
AACACATTGAGGGACTTTTAAAAGCTGAAGAGCACAGCTGGTCCCTTGCGGAATTGGTACATGCAGTAGTTTTACTCACACACTATCATT
CTCTTGCCTCATTCACATTCGGCTGTGGAATCAGTCCAGAAATTCATTGTGATGGTGGCCACACATTCAGACCTCCTTCTGTTAGCAACT
ACTGCATCTGTGACATTACAAATGGCAATCACAGTGTGGATGAGATGCCGGTCAACTCAGCAGAAAATGTTTCTGTAAGTGATTCTTTCT
TTGAGGTTGAAGCCCTCATGGAAAAGATGAGGCAGTTACAGGAATGTCGAGATGAAGAAGAGGCAAGTCAGGAAGAGATGGCTTCACGTT
TTGAAATAGAAAAAAGAGAGAGTATGTTTGTCTTCTCTTCAGATGATGAAGAAGTTACACCAGCAAGAGCTGTATCTCGTCATTTTGAGG
ATACTAGTTATGGCTATAAAGATTTCTCTAGACATGGGATGCATGTTCCAACATTTCGTGTCCAGGACTATTGCTGGGAAGATCATGGTT
ATTCTTTGGTAAATCGCCTTTATCCAGATGTGGGACAGTTGATTGATGAAAAATTTCACATTGCTTACAATCTTACTTATAATACAATGG
CAATGCACAAAGATGTTGATACCTCAATGCTTAGACGGGCAATTTGGAACTATATTCACTGCATGTTTGGAATAAGATATGATGATTATG
ACTATGGTGAAATTAACCAGCTATTGGATCGTAGCTTTAAAGTTTATATCAAAACTGTTGTTTGCACTCCTGAAAAGGTTACCAAAAGAA
TGTATGATAGCTTCTGGAGGCAGTTCAAGCACTCTGAGAAGGTTCATGTTAATCTGCTTCTTATAGAAGCTAGGATGCAAGCAGAACTCC
TTTATGCTCTGAGAGCCATTACCCGCTATATGACCTGATGCCTTTCCTTCATTAAAGATGATTCTGGAATGATCAGCAGATATAGTCTAC
AAGGGGGAAGGTACTAAGCCCCAGGACCAATGGTAGACAAAATAATTCAGAAATCCATTGTGCCATGATTCCTTTAGTTTCTGCTATTTT
TCTGTGGAAAACCACTGCTGGCACAAGCAGTGACTGTTTGGCAGCTTCAAGTTTAGAGCTGTGAAGACAGGCTGCCATTCACAGTATTTT
GCTTTTTGACAGTACAAGATGCTGTGTAACTGTTTTAATACAGCAAATAGTAACTCTCCAAATCCTGTTGCTTTTATGTTAAATAAGATA
ACAAGAATTGGAGCATGCAAAGAATGGGACTTGGATAATGACTTAAGCTTTATATGTAAAGAATTTTAGAAGATCTTGGTGCTGCTATTC
CTGCTGGAGGAATGAATAGATGGCTGTTTCAGTTAAGCTATTAGTAATAAAAGTGAACATTGCTACTATCTGAGCCTACATACATAACTT
GTGTGATTTCAAATTAAACTTGCATTATGTGTTAATTTTCTTGCATCTAAAAAAGCATAGAATTCCTACTCACACAGCTCAGCAACAACC
ATTTTGATGGTAACAGTTAATTTCTTTCATTAGTTTTTTAAATTCAGGGTTCTGGATATTAAATTAAAATGGCATTCTTAAAGATTTTCT
TCAAAAAGCAATCCTAAATGAAAGTGTGTAAATTATAAGAAGCTGGCGATCTTTTGATATGCTGTTTCACAGGATCCTGACACTGGAGGG
CAGCTGTCTTGTGCATTACTTGTGTTTCCAGCACCAAAGTTGTGGGACATGTTGCTGTAGACTGCTGCGCAGTCCTGGGTGCATTCAGTC
TCTCTGCCTCTGCCTGCCTCCTGGTCCCCACTTTAAAGGCTGTGCAGCTCCTTAAATAATAAAGCTGGAAAATATTTTTAGTCGGGTTAT
CAAATTTGATTTACAAAAACGCTAACTTTGTTTGAAATGCAAACAGGTTTGAAAATATGTATTAAGTACTTTGTATTCTGGAAGCGTGAA

>In-frame_ENST00000527524_ENST00000436639_TCGA-04-1514-01A_GRIK4_chr11_120745952_+_SESN1_chr6_109323546_length(amino acids)=846AA_start in transcript=287_stop in transcript=2827
MPRVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRDSEYETAETMCQILPKG
VVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLR
QFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSI
FNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLT
GHIEFNSKGQRSNYALKILQFTRNGFRQELGIRIPRPLGQGPSRFIPEKEILQVGSEDAQMHALFADSFAALGRLDNITLVMVFHPQYLE
SFLKTQHYLLQMDGPLPLHYRHYIGIMAAARHQCSYLVNLHVNDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGL
LKAEEHSWSLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVDEMPVNSAENVSVSDSFFEVEAL
MEKMRQLQECRDEEEASQEEMASRFEIEKRESMFVFSSDDEEVTPARAVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNR
LYPDVGQLIDEKFHIAYNLTYNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFW

--------------------------------------------------------------
>In-frame_ENST00000438375_ENST00000436639_TCGA-04-1514-01A_GRIK4_chr11_120745952_+_SESN1_chr6_109323546_length(transcript)=3990nt_BP=1506nt
CCTTTCCCGATTCCCCGACGTTTCGGGAGGAGTGGGGTCGGAGCGCAGGGCTGGGAAGGGTCTTAGGACCCAGGAAGGAGACGGGTGCCT
CCCAGAGAGGACCCCATCCCCTCCGAGGTCCGGGCGGCTCCCGGCCTCTCCCTGGGGTGCCGTAGCCCCCCTCGACCCGCCTTCCCGCAG
CCGCAGTCGTTCGGGCCTGGAGGTGGCCGGGCATCGGTGCCGACGCCGCGAGGGCAGCGCCCGCGGCGGGAATACTAATGCACCCTAAAG
GGCACGGCCGCCGCCGCAGCAGAGTTATGTCATGCCCAGGCCAGCAGGGGGCTCCATGAGGATTCATAGAAGATGCCCCGCGTCTCGGCG
CCTTTGGTGCTGCTTCCTGCGTGGCTCGTGATGGTCGCCTGCAGCCCGCACTCCTTGAGGATCGCTGCTATCTTGGACGACCCCATGGAG
TGCAGCAGAGGGGAGCGGCTCTCCATCACCCTGGCCAAGAACCGCATCAACCGCGCTCCTGAGAGGCTGGGCAAGGCCAAGGTCGAAGTG
GACATCTTTGAGCTTCTCAGAGACAGCGAGTACGAGACTGCAGAAACCATGTGTCAGATCCTCCCCAAGGGGGTGGTCGCTGTCCTCGGA
CCATCGTCCAGCCCAGCCTCCAGCTCCATCATCAGCAACATCTGTGGAGAGAAGGAGGTCCCTCACTTCAAAGTGGCCCCAGAGGAGTTC
GTCAAGTTCCAGTTCCAGAGATTCACAACCCTGAACCTCCACCCCAGCAACACTGACATCAGCGTGGCTGTAGCTGGGATCCTGAACTTC
TTCAACTGCACCACCGCCTGCCTCATCTGTGCCAAAGCAGAATGCCTTTTAAACCTAGAGAAGCTGCTCCGGCAATTCCTTATCTCCAAG
GACACGCTGTCCGTCCGCATGCTGGATGACACCCGGGACCCCACCCCGCTCCTCAAGGAGATCCGGGACGACAAGACCGCCACCATCATC
ATCCACGCCAACGCCTCCATGTCCCACACCATCCTCCTGAAGGCAGCCGAACTTGGGATGGTGTCAGCCTATTACACATACATCTTCACT
AATCTGGAGTTCTCACTCCAGAGAATGGACAGCCTTGTGGATGATCGTGTCAACATCCTGGGATTTTCCATTTTCAACCAATCCCATGCT
TTCTTCCAAGAGTTTGCCCAGAGCCTCAACCAGTCCTGGCAGGAGAACTGTGACCATGTGCCCTTCACTGGGCCTGCGCTCTCCTCGGCC
CTGCTGTTTGATGCTGTCTATGCTGTGGTGACTGCGGTGCAGGAACTGAACCGGAGCCAAGAGATCGGCGTGAAGCCCTTGTCCTGCGGC
TCGGCCCAGATCTGGCAGCACGGCACCAGCCTCATGAACTACCTGCGCATGGTAGAATTGGAAGGTCTTACCGGCCACATTGAATTCAAC
AGCAAAGGCCAGAGGTCCAACTACGCTTTGAAAATCTTACAGTTCACAAGGAATGGTTTTCGGCAGGAACTTGGCATTAGAATTCCTCGA
CCACTAGGACAGGGACCAAGCAGATTCATCCCAGAAAAGGAGATCCTCCAAGTGGGGAGTGAAGACGCACAGATGCATGCTTTATTTGCA
GATTCTTTTGCTGCTTTGGGCCGTTTGGATAACATTACGTTAGTGATGGTTTTCCACCCACAATATTTAGAAAGTTTCTTAAAAACTCAG
CACTATCTACTGCAAATGGATGGGCCGTTACCCCTACATTATCGTCACTACATTGGAATAATGGCTGCGGCAAGACATCAGTGCTCCTAC
TTAGTGAACCTGCATGTAAATGATTTCCTTCATGTTGGTGGGGACCCCAAGTGGCTCAATGGTTTAGAGAATGCTCCTCAAAAACTACAG
AATTTAGGAGAACTTAACAAAGTGTTAGCCCATAGACCTTGGCTTATTACCAAAGAACACATTGAGGGACTTTTAAAAGCTGAAGAGCAC
AGCTGGTCCCTTGCGGAATTGGTACATGCAGTAGTTTTACTCACACACTATCATTCTCTTGCCTCATTCACATTCGGCTGTGGAATCAGT
CCAGAAATTCATTGTGATGGTGGCCACACATTCAGACCTCCTTCTGTTAGCAACTACTGCATCTGTGACATTACAAATGGCAATCACAGT
GTGGATGAGATGCCGGTCAACTCAGCAGAAAATGTTTCTGTAAGTGATTCTTTCTTTGAGGTTGAAGCCCTCATGGAAAAGATGAGGCAG
TTACAGGAATGTCGAGATGAAGAAGAGGCAAGTCAGGAAGAGATGGCTTCACGTTTTGAAATAGAAAAAAGAGAGAGTATGTTTGTCTTC
TCTTCAGATGATGAAGAAGTTACACCAGCAAGAGCTGTATCTCGTCATTTTGAGGATACTAGTTATGGCTATAAAGATTTCTCTAGACAT
GGGATGCATGTTCCAACATTTCGTGTCCAGGACTATTGCTGGGAAGATCATGGTTATTCTTTGGTAAATCGCCTTTATCCAGATGTGGGA
CAGTTGATTGATGAAAAATTTCACATTGCTTACAATCTTACTTATAATACAATGGCAATGCACAAAGATGTTGATACCTCAATGCTTAGA
CGGGCAATTTGGAACTATATTCACTGCATGTTTGGAATAAGATATGATGATTATGACTATGGTGAAATTAACCAGCTATTGGATCGTAGC
TTTAAAGTTTATATCAAAACTGTTGTTTGCACTCCTGAAAAGGTTACCAAAAGAATGTATGATAGCTTCTGGAGGCAGTTCAAGCACTCT
GAGAAGGTTCATGTTAATCTGCTTCTTATAGAAGCTAGGATGCAAGCAGAACTCCTTTATGCTCTGAGAGCCATTACCCGCTATATGACC
TGATGCCTTTCCTTCATTAAAGATGATTCTGGAATGATCAGCAGATATAGTCTACAAGGGGGAAGGTACTAAGCCCCAGGACCAATGGTA
GACAAAATAATTCAGAAATCCATTGTGCCATGATTCCTTTAGTTTCTGCTATTTTTCTGTGGAAAACCACTGCTGGCACAAGCAGTGACT
GTTTGGCAGCTTCAAGTTTAGAGCTGTGAAGACAGGCTGCCATTCACAGTATTTTGCTTTTTGACAGTACAAGATGCTGTGTAACTGTTT
TAATACAGCAAATAGTAACTCTCCAAATCCTGTTGCTTTTATGTTAAATAAGATAACAAGAATTGGAGCATGCAAAGAATGGGACTTGGA
TAATGACTTAAGCTTTATATGTAAAGAATTTTAGAAGATCTTGGTGCTGCTATTCCTGCTGGAGGAATGAATAGATGGCTGTTTCAGTTA
AGCTATTAGTAATAAAAGTGAACATTGCTACTATCTGAGCCTACATACATAACTTGTGTGATTTCAAATTAAACTTGCATTATGTGTTAA
TTTTCTTGCATCTAAAAAAGCATAGAATTCCTACTCACACAGCTCAGCAACAACCATTTTGATGGTAACAGTTAATTTCTTTCATTAGTT
TTTTAAATTCAGGGTTCTGGATATTAAATTAAAATGGCATTCTTAAAGATTTTCTTCAAAAAGCAATCCTAAATGAAAGTGTGTAAATTA
TAAGAAGCTGGCGATCTTTTGATATGCTGTTTCACAGGATCCTGACACTGGAGGGCAGCTGTCTTGTGCATTACTTGTGTTTCCAGCACC
AAAGTTGTGGGACATGTTGCTGTAGACTGCTGCGCAGTCCTGGGTGCATTCAGTCTCTCTGCCTCTGCCTGCCTCCTGGTCCCCACTTTA
AAGGCTGTGCAGCTCCTTAAATAATAAAGCTGGAAAATATTTTTAGTCGGGTTATCAAATTTGATTTACAAAAACGCTAACTTTGTTTGA
AATGCAAACAGGTTTGAAAATATGTATTAAGTACTTTGTATTCTGGAAGCGTGAATTGCTTTTGAAGTCTGTCAGTATTACTGGTATTTT

>In-frame_ENST00000438375_ENST00000436639_TCGA-04-1514-01A_GRIK4_chr11_120745952_+_SESN1_chr6_109323546_length(amino acids)=846AA_start in transcript=342_stop in transcript=2882
MPRVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRDSEYETAETMCQILPKG
VVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLR
QFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSI
FNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLT
GHIEFNSKGQRSNYALKILQFTRNGFRQELGIRIPRPLGQGPSRFIPEKEILQVGSEDAQMHALFADSFAALGRLDNITLVMVFHPQYLE
SFLKTQHYLLQMDGPLPLHYRHYIGIMAAARHQCSYLVNLHVNDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGL
LKAEEHSWSLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVDEMPVNSAENVSVSDSFFEVEAL
MEKMRQLQECRDEEEASQEEMASRFEIEKRESMFVFSSDDEEVTPARAVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNR
LYPDVGQLIDEKFHIAYNLTYNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFW

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Fusion Gene PPI Analysis for GRIK4-SESN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GRIK4-SESN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGRIK4Q16099DB00237ButabarbitalAntagonistSmall moleculeApproved|Illicit
HgeneGRIK4Q16099DB00237ButabarbitalAntagonistSmall moleculeApproved|Illicit
HgeneGRIK4Q16099DB00142Glutamic acidSmall moleculeApproved|Nutraceutical
HgeneGRIK4Q16099DB00142Glutamic acidSmall moleculeApproved|Nutraceutical

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Related Diseases for GRIK4-SESN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGRIK4C0005586Bipolar Disorder5PSYGENET
HgeneGRIK4C0036341Schizophrenia4PSYGENET
HgeneGRIK4C0005587Depression, Bipolar1PSYGENET
HgeneGRIK4C0033975Psychotic Disorders1PSYGENET
HgeneGRIK4C0041696Unipolar Depression1PSYGENET
HgeneGRIK4C0349204Nonorganic psychosis1PSYGENET
HgeneGRIK4C1269683Major Depressive Disorder1PSYGENET