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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GRIP1-XCL1 (FusionGDB2 ID:34726)

Fusion Gene Summary for GRIP1-XCL1

check button Fusion gene summary
Fusion gene informationFusion gene name: GRIP1-XCL1
Fusion gene ID: 34726
HgeneTgene
Gene symbol

GRIP1

XCL1

Gene ID

85329

6375

Gene namegalectin 12X-C motif chemokine ligand 1
SynonymsGAL12|GRIP1ATAC|LPTN|LTN|SCM-1|SCM-1a|SCM1|SCM1A|SCYC1
Cytomap

11q12.3

1q24.2

Type of geneprotein-codingprotein-coding
Descriptiongalectin-12galectin-related inhibitor of proliferationlectin, galactoside-binding, soluble, 12testicular secretory protein Li 26lymphotactinSCM-1-alphaXC chemokine ligand 1c motif chemokine 1chemokine (C motif) ligand 1cytokine SCM-1lymphotaxinsingle cysteine motif 1asmall inducible cytokine subfamily C, member 1 (lymphotactin)small-inducible cytokine C1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000398016, ENST00000359742, 
ENST00000286445, ENST00000542021, 
ENST00000367818, 
Fusion gene scores* DoF score20 X 20 X 6=24001 X 1 X 1=1
# samples 221
** MAII scorelog2(22/2400*10)=-3.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: GRIP1 [Title/Abstract] AND XCL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGRIP1(66932858)-XCL1(168550290), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGRIP1

GO:0097193

intrinsic apoptotic signaling pathway

11435439

TgeneXCL1

GO:0001916

positive regulation of T cell mediated cytotoxicity

18832695

TgeneXCL1

GO:0002725

negative regulation of T cell cytokine production

10887101

TgeneXCL1

GO:0007267

cell-cell signaling

7602097

TgeneXCL1

GO:0009615

response to virus

14734774

TgeneXCL1

GO:0010820

positive regulation of T cell chemotaxis

7602097

TgeneXCL1

GO:0032689

negative regulation of interferon-gamma production

10887101

TgeneXCL1

GO:0032703

negative regulation of interleukin-2 production

10887101

TgeneXCL1

GO:0032733

positive regulation of interleukin-10 production

18832695

TgeneXCL1

GO:0035782

mature natural killer cell chemotaxis

9029087

TgeneXCL1

GO:0043433

negative regulation of DNA-binding transcription factor activity

10887101

TgeneXCL1

GO:0045892

negative regulation of transcription, DNA-templated

10887101

TgeneXCL1

GO:0050727

regulation of inflammatory response

18832695

TgeneXCL1

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

7602097

TgeneXCL1

GO:0071636

positive regulation of transforming growth factor beta production

18832695

TgeneXCL1

GO:0071663

positive regulation of granzyme B production

18832695

TgeneXCL1

GO:2000503

positive regulation of natural killer cell chemotaxis

9029087

TgeneXCL1

GO:2000513

positive regulation of granzyme A production

18832695

TgeneXCL1

GO:2000518

negative regulation of T-helper 1 cell activation

10887101

TgeneXCL1

GO:2000562

negative regulation of CD4-positive, alpha-beta T cell proliferation

10887101

TgeneXCL1

GO:2000566

positive regulation of CD8-positive, alpha-beta T cell proliferation

10887101


check buttonFusion gene breakpoints across GRIP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across XCL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-8354-01AGRIP1chr12

66932858

-XCL1chr1

168550290

+
ChimerDB4LUSCTCGA-85-8354GRIP1chr12

66932858

-XCL1chr1

168550290

+
ChimerDB4LUSCTCGA-85-8354-01AGRIP1chr12

66932858

-XCL1chr1

168550290

+


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Fusion Gene ORF analysis for GRIP1-XCL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000398016ENST00000367818GRIP1chr12

66932858

-XCL1chr1

168550290

+
In-frameENST00000359742ENST00000367818GRIP1chr12

66932858

-XCL1chr1

168550290

+
In-frameENST00000286445ENST00000367818GRIP1chr12

66932858

-XCL1chr1

168550290

+
intron-3CDSENST00000542021ENST00000367818GRIP1chr12

66932858

-XCL1chr1

168550290

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398016GRIP1chr1266932858-ENST00000367818XCL1chr1168550290+151348769509146
ENST00000359742GRIP1chr1266932858-ENST00000367818XCL1chr1168550290+1685659582118154
ENST00000286445GRIP1chr1266932858-ENST00000367818XCL1chr1168550290+1685659582118154

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398016ENST00000367818GRIP1chr1266932858-XCL1chr1168550290+0.0070996240.9929004
ENST00000359742ENST00000367818GRIP1chr1266932858-XCL1chr1168550290+0.002909120.9970908
ENST00000286445ENST00000367818GRIP1chr1266932858-XCL1chr1168550290+0.002909120.9970908

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Fusion Genomic Features for GRIP1-XCL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GRIP1chr1266932857-XCL1chr1168550289+1.24E-050.9999876
GRIP1chr1266932857-XCL1chr1168550289+1.24E-050.9999876
GRIP1chr1266932857-XCL1chr1168550289+1.24E-050.9999876
GRIP1chr1266932857-XCL1chr1168550289+1.24E-050.9999876

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRIP1-XCL1


check button Go to

FGviewer for the breakpoints of chr12:66932858-chr1:168550290

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRIP1chr12:66932858chr1:168550290ENST00000286445-42453_136139.333333333333341114.0DomainPDZ 1
HgeneGRIP1chr12:66932858chr1:168550290ENST00000359742-42553_136139.333333333333341129.0DomainPDZ 1
HgeneGRIP1chr12:66932858chr1:168550290ENST00000398016-42453_136139.333333333333341077.0DomainPDZ 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRIP1chr12:66932858chr1:168550290ENST00000286445-4241004_1086139.333333333333341114.0DomainPDZ 7
HgeneGRIP1chr12:66932858chr1:168550290ENST00000286445-424150_238139.333333333333341114.0DomainPDZ 2
HgeneGRIP1chr12:66932858chr1:168550290ENST00000286445-424252_336139.333333333333341114.0DomainPDZ 3
HgeneGRIP1chr12:66932858chr1:168550290ENST00000286445-424472_561139.333333333333341114.0DomainPDZ 4
HgeneGRIP1chr12:66932858chr1:168550290ENST00000286445-424573_658139.333333333333341114.0DomainPDZ 5
HgeneGRIP1chr12:66932858chr1:168550290ENST00000286445-424673_755139.333333333333341114.0DomainPDZ 6
HgeneGRIP1chr12:66932858chr1:168550290ENST00000359742-4251004_1086139.333333333333341129.0DomainPDZ 7
HgeneGRIP1chr12:66932858chr1:168550290ENST00000359742-425150_238139.333333333333341129.0DomainPDZ 2
HgeneGRIP1chr12:66932858chr1:168550290ENST00000359742-425252_336139.333333333333341129.0DomainPDZ 3
HgeneGRIP1chr12:66932858chr1:168550290ENST00000359742-425472_561139.333333333333341129.0DomainPDZ 4
HgeneGRIP1chr12:66932858chr1:168550290ENST00000359742-425573_658139.333333333333341129.0DomainPDZ 5
HgeneGRIP1chr12:66932858chr1:168550290ENST00000359742-425673_755139.333333333333341129.0DomainPDZ 6
HgeneGRIP1chr12:66932858chr1:168550290ENST00000398016-4241004_1086139.333333333333341077.0DomainPDZ 7
HgeneGRIP1chr12:66932858chr1:168550290ENST00000398016-424150_238139.333333333333341077.0DomainPDZ 2
HgeneGRIP1chr12:66932858chr1:168550290ENST00000398016-424252_336139.333333333333341077.0DomainPDZ 3
HgeneGRIP1chr12:66932858chr1:168550290ENST00000398016-424472_561139.333333333333341077.0DomainPDZ 4
HgeneGRIP1chr12:66932858chr1:168550290ENST00000398016-424573_658139.333333333333341077.0DomainPDZ 5
HgeneGRIP1chr12:66932858chr1:168550290ENST00000398016-424673_755139.333333333333341077.0DomainPDZ 6


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Fusion Gene Sequence for GRIP1-XCL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000398016_ENST00000367818_TCGA-85-8354-01A_GRIP1_chr12_66932858_-_XCL1_chr1_168550290_length(transcript)=1513nt_BP=487nt
CTGCTGCTGCTGCAGCCACCAGAGCAGAGAGCCTTGAGTACACTTTGCCACAGAAAGCAGTGAGCAAGAATGATAGCTGTCTCTTTTAAA
TGCCGTTGTCAAATTCTGAGGCGACTTACTAAAGATGAGAGTCCCTACACTAAATCCGCCAGCCAGACAAAGCCGCCTGATGGAGCGTTG
GCTGTGAGGAGACAGAGCATCCCAGAGGAATTCAAGGGCTCCACAGTCGTCGAGCTGATGAAGAAGGAAGGCACTACCCTGGGTCTGACG
GTATCGGGAGGAATTGATAAGGATGGCAAGCCAAGAGTATCTAATCTGCGGCAAGGAGGAATTGCTGCTAGAAGTGACCAGCTGGATGTG
GGTGACTACATCAAAGCAGTGAATGGAATCAACCTGGCCAAATTCCGCCATGACGAGATCATCAGCTTGCTGAAGAATGTGGGAGAAAGA
GTGGTTCTTGAAGTAGAGTACGAGCTTCCACCGGTCTTTTTATTACCAAACGTGGCCTAAAAGTCTGTGCTGATCCACAAGCCACATGGG
TGAGAGACGTGGTCAGGAGCATGGACAGGAAATCCAACACCAGAAATAACATGATCCAGACCAAGCCAACAGGAACCCAGCAATCGACCA
ATACAGCTGTGACTCTGACTGGCTAGTAGTCTCTGGCACCCTGTCCGTCTCCAGCCAGCCAGCTCATTTCACTTTACACGCTCATGGACT
GAGTTTATACTCACCTTTTATGAAAGCACTGCATGAATAAAATTATTCCTTTGTATTTTTACTTTTAAATGTCTTCTGTATTCACTTATA
TGTTCTAATTAATAAATTATTTATTATTAAGAATAGTTCCCTAGTCTATTCATTATATTTAGGGAAAGGTAGTGTATCATTGTTGTTTGA
TTTCTGACCTTGTACCTCTCTTTGATGGTAACCATAATGGAAGAGATTCTGGCTAGTGTCTATCAGAGGTGAAAGCTATATCAATCTCTC
TTAGAGTCCAGCTTGTAATGGTTCTTTACACATCAGTCACAAGTTACAGCTGTGACAATGGCAACAATTTGAGATGTATTTCAACTTGTC
TCTATAATAGAATTCTGTTTATAGAATAAGGGAGAAAATAATCCAGTCTTCACTGGGTTCCCATTCTGAGGGTCCACTACTCAAAAATTT
GCTTCACTCAATTTTTTTCACCTCTTTGTGTTTTATTTTGGTGTCCTATTAAAGGAATAAAATGACACAACTTGTCCCTTTTTTGTCCCA
TTAGCAAAAATTAGAATTTTGGTATAAAGAAACTTTATTCAAGTAAAAATCAATACCCTTTGAATTGGACAATAATCTCACTACCTTATT
AGGATTTCTGTATTTGCCATTACGCTAGTTATCATGCATGTTATGCTTTACTGCGAATAAGCTTTTAATGCTCCAAATGCTGACCCATGC

>In-frame_ENST00000398016_ENST00000367818_TCGA-85-8354-01A_GRIP1_chr12_66932858_-_XCL1_chr1_168550290_length(amino acids)=146AA_start in transcript=69_stop in transcript=509
MIAVSFKCRCQILRRLTKDESPYTKSASQTKPPDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAA

--------------------------------------------------------------
>In-frame_ENST00000359742_ENST00000367818_TCGA-85-8354-01A_GRIP1_chr12_66932858_-_XCL1_chr1_168550290_length(transcript)=1685nt_BP=659nt
GTGATTGTGAAGGGGGAGGAGGCTGTGGCAGGCAGGGGTGGTAGTAGTAGTGAATGACACAGATTTGCCAGATGACATGTAGCGGACCTC
TGCATCAGCCAAGAGGAATTAAGCTTTGTCACTCCCCACTGGGACTACCTTTCTCCTGGTATGTGCGCAAGGAATTCATATGCTGCTGCT
GCTGCAGCCACCAGAGCAGAGAGCCTTGAGTACACTTTGCCACAGAAAGCAGTGAGCAAGAATGATAGCTGTCTCTTTTAAATGCCGTTG
TCAAATTCTGAGGCGACTTACTAAAGATGAGAGTCCCTACACTAAATCCGCCAGCCAGACAAAGCCGCCTGATGGAGCGTTGGCTGTGAG
GAGACAGAGCATCCCAGAGGAATTCAAGGGCTCCACAGTCGTCGAGCTGATGAAGAAGGAAGGCACTACCCTGGGTCTGACGGTATCGGG
AGGAATTGATAAGGATGGCAAGCCAAGAGTATCTAATCTGCGGCAAGGAGGAATTGCTGCTAGAAGTGACCAGCTGGATGTGGGTGACTA
CATCAAAGCAGTGAATGGAATCAACCTGGCCAAATTCCGCCATGACGAGATCATCAGCTTGCTGAAGAATGTGGGAGAAAGAGTGGTTCT
TGAAGTAGAGTACGAGCTTCCACCGGTCTTTTTATTACCAAACGTGGCCTAAAAGTCTGTGCTGATCCACAAGCCACATGGGTGAGAGAC
GTGGTCAGGAGCATGGACAGGAAATCCAACACCAGAAATAACATGATCCAGACCAAGCCAACAGGAACCCAGCAATCGACCAATACAGCT
GTGACTCTGACTGGCTAGTAGTCTCTGGCACCCTGTCCGTCTCCAGCCAGCCAGCTCATTTCACTTTACACGCTCATGGACTGAGTTTAT
ACTCACCTTTTATGAAAGCACTGCATGAATAAAATTATTCCTTTGTATTTTTACTTTTAAATGTCTTCTGTATTCACTTATATGTTCTAA
TTAATAAATTATTTATTATTAAGAATAGTTCCCTAGTCTATTCATTATATTTAGGGAAAGGTAGTGTATCATTGTTGTTTGATTTCTGAC
CTTGTACCTCTCTTTGATGGTAACCATAATGGAAGAGATTCTGGCTAGTGTCTATCAGAGGTGAAAGCTATATCAATCTCTCTTAGAGTC
CAGCTTGTAATGGTTCTTTACACATCAGTCACAAGTTACAGCTGTGACAATGGCAACAATTTGAGATGTATTTCAACTTGTCTCTATAAT
AGAATTCTGTTTATAGAATAAGGGAGAAAATAATCCAGTCTTCACTGGGTTCCCATTCTGAGGGTCCACTACTCAAAAATTTGCTTCACT
CAATTTTTTTCACCTCTTTGTGTTTTATTTTGGTGTCCTATTAAAGGAATAAAATGACACAACTTGTCCCTTTTTTGTCCCATTAGCAAA
AATTAGAATTTTGGTATAAAGAAACTTTATTCAAGTAAAAATCAATACCCTTTGAATTGGACAATAATCTCACTACCTTATTAGGATTTC
TGTATTTGCCATTACGCTAGTTATCATGCATGTTATGCTTTACTGCGAATAAGCTTTTAATGCTCCAAATGCTGACCCATGCAATATTTC

>In-frame_ENST00000359742_ENST00000367818_TCGA-85-8354-01A_GRIP1_chr12_66932858_-_XCL1_chr1_168550290_length(amino acids)=154AA_start in transcript=582_stop in transcript=118
MAEFGQVDSIHCFDVVTHIQLVTSSSNSSLPQIRYSWLAILINSSRYRQTQGSAFLLHQLDDCGALEFLWDALSPHSQRSIRRLCLAGGF

--------------------------------------------------------------
>In-frame_ENST00000286445_ENST00000367818_TCGA-85-8354-01A_GRIP1_chr12_66932858_-_XCL1_chr1_168550290_length(transcript)=1685nt_BP=659nt
GTGATTGTGAAGGGGGAGGAGGCTGTGGCAGGCAGGGGTGGTAGTAGTAGTGAATGACACAGATTTGCCAGATGACATGTAGCGGACCTC
TGCATCAGCCAAGAGGAATTAAGCTTTGTCACTCCCCACTGGGACTACCTTTCTCCTGGTATGTGCGCAAGGAATTCATATGCTGCTGCT
GCTGCAGCCACCAGAGCAGAGAGCCTTGAGTACACTTTGCCACAGAAAGCAGTGAGCAAGAATGATAGCTGTCTCTTTTAAATGCCGTTG
TCAAATTCTGAGGCGACTTACTAAAGATGAGAGTCCCTACACTAAATCCGCCAGCCAGACAAAGCCGCCTGATGGAGCGTTGGCTGTGAG
GAGACAGAGCATCCCAGAGGAATTCAAGGGCTCCACAGTCGTCGAGCTGATGAAGAAGGAAGGCACTACCCTGGGTCTGACGGTATCGGG
AGGAATTGATAAGGATGGCAAGCCAAGAGTATCTAATCTGCGGCAAGGAGGAATTGCTGCTAGAAGTGACCAGCTGGATGTGGGTGACTA
CATCAAAGCAGTGAATGGAATCAACCTGGCCAAATTCCGCCATGACGAGATCATCAGCTTGCTGAAGAATGTGGGAGAAAGAGTGGTTCT
TGAAGTAGAGTACGAGCTTCCACCGGTCTTTTTATTACCAAACGTGGCCTAAAAGTCTGTGCTGATCCACAAGCCACATGGGTGAGAGAC
GTGGTCAGGAGCATGGACAGGAAATCCAACACCAGAAATAACATGATCCAGACCAAGCCAACAGGAACCCAGCAATCGACCAATACAGCT
GTGACTCTGACTGGCTAGTAGTCTCTGGCACCCTGTCCGTCTCCAGCCAGCCAGCTCATTTCACTTTACACGCTCATGGACTGAGTTTAT
ACTCACCTTTTATGAAAGCACTGCATGAATAAAATTATTCCTTTGTATTTTTACTTTTAAATGTCTTCTGTATTCACTTATATGTTCTAA
TTAATAAATTATTTATTATTAAGAATAGTTCCCTAGTCTATTCATTATATTTAGGGAAAGGTAGTGTATCATTGTTGTTTGATTTCTGAC
CTTGTACCTCTCTTTGATGGTAACCATAATGGAAGAGATTCTGGCTAGTGTCTATCAGAGGTGAAAGCTATATCAATCTCTCTTAGAGTC
CAGCTTGTAATGGTTCTTTACACATCAGTCACAAGTTACAGCTGTGACAATGGCAACAATTTGAGATGTATTTCAACTTGTCTCTATAAT
AGAATTCTGTTTATAGAATAAGGGAGAAAATAATCCAGTCTTCACTGGGTTCCCATTCTGAGGGTCCACTACTCAAAAATTTGCTTCACT
CAATTTTTTTCACCTCTTTGTGTTTTATTTTGGTGTCCTATTAAAGGAATAAAATGACACAACTTGTCCCTTTTTTGTCCCATTAGCAAA
AATTAGAATTTTGGTATAAAGAAACTTTATTCAAGTAAAAATCAATACCCTTTGAATTGGACAATAATCTCACTACCTTATTAGGATTTC
TGTATTTGCCATTACGCTAGTTATCATGCATGTTATGCTTTACTGCGAATAAGCTTTTAATGCTCCAAATGCTGACCCATGCAATATTTC

>In-frame_ENST00000286445_ENST00000367818_TCGA-85-8354-01A_GRIP1_chr12_66932858_-_XCL1_chr1_168550290_length(amino acids)=154AA_start in transcript=582_stop in transcript=118
MAEFGQVDSIHCFDVVTHIQLVTSSSNSSLPQIRYSWLAILINSSRYRQTQGSAFLLHQLDDCGALEFLWDALSPHSQRSIRRLCLAGGF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GRIP1-XCL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GRIP1-XCL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GRIP1-XCL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGRIP1C0265233Cryptophthalmos syndrome3GENOMICS_ENGLAND;ORPHANET
HgeneGRIP1C4551480FRASER SYNDROME 13GENOMICS_ENGLAND
HgeneGRIP1C4540040FRASER SYNDROME 32GENOMICS_ENGLAND
HgeneGRIP1C0015397Disorder of eye1GENOMICS_ENGLAND
HgeneGRIP1C0152423Congenital small ears1GENOMICS_ENGLAND
HgeneGRIP1C0152427Polydactyly1GENOMICS_ENGLAND