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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GSK3B-CDC5L (FusionGDB2 ID:34910)

Fusion Gene Summary for GSK3B-CDC5L

Fusion gene summary

Fusion gene information	Fusion gene name: GSK3B-CDC5L
	Fusion gene ID: 34910
		Hgene	Tgene
	Gene symbol	GSK3B	CDC5L
	Gene ID	2932	988
	Gene name	glycogen synthase kinase 3 beta	cell division cycle 5 like
	Synonyms	-	CDC5\|CDC5-LIKE\|CEF1\|PCDC5RP\|dJ319D22.1
	Cytomap	3q13.33	6p21.1
	Type of gene	protein-coding	protein-coding
	Description	glycogen synthase kinase-3 betaGSK-3 betaGSK3beta isoformserine/threonine-protein kinase GSK3B	cell division cycle 5-like proteinCDC5 cell division cycle 5-likeCdc5-related proteindJ319D22.1 (CDC5-like protein)pombe cdc5-related protein
	Modification date	20200315	20200313
	UniProtAcc	.	Q99459
	Ensembl transtripts involved in fusion gene	ENST00000264235, ENST00000316626, ENST00000473886,	ENST00000371477,
Fusion gene scores	* DoF score	31 X 22 X 12=8184	8 X 6 X 6=288
	# samples	36	8
	** MAII score	log2(36/8184*10)=-4.50673733341565 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GSK3B [Title/Abstract] AND CDC5L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GSK3B(119812193)-CDC5L(44413391), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GSK3B	GO:0005977	glycogen metabolic process	8638126
Hgene	GSK3B	GO:0006468	protein phosphorylation	11035810\|16315267\|20937854
Hgene	GSK3B	GO:0006983	ER overload response	14744935
Hgene	GSK3B	GO:0018105	peptidyl-serine phosphorylation	8638126\|11104755\|11955436\|14744935\|17139249
Hgene	GSK3B	GO:0018107	peptidyl-threonine phosphorylation	11955436\|17139249\|25897075
Hgene	GSK3B	GO:0031175	neuron projection development	19830702
Hgene	GSK3B	GO:0031334	positive regulation of protein complex assembly	8638126
Hgene	GSK3B	GO:0032091	negative regulation of protein binding	16890161
Hgene	GSK3B	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	19364825
Hgene	GSK3B	GO:0035556	intracellular signal transduction	14749367
Hgene	GSK3B	GO:0043066	negative regulation of apoptotic process	14744935
Hgene	GSK3B	GO:0046777	protein autophosphorylation	23184662
Hgene	GSK3B	GO:0046827	positive regulation of protein export from nucleus	14744935
Hgene	GSK3B	GO:1901215	negative regulation of neuron death	19830702
Hgene	GSK3B	GO:1901216	positive regulation of neuron death	18508033
Hgene	GSK3B	GO:2000300	regulation of synaptic vesicle exocytosis	17989287
Tgene	CDC5L	GO:0000398	mRNA splicing, via spliceosome	28076346
Tgene	CDC5L	GO:0045944	positive regulation of transcription by RNA polymerase II	11082045

Fusion gene breakpoints across GSK3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CDC5L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4H6	GSK3B	chr3	119812193	-	CDC5L	chr6	44413391	+

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Fusion Gene ORF analysis for GSK3B-CDC5L

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000264235	ENST00000371477	GSK3B	chr3	119812193	-	CDC5L	chr6	44413391	+
In-frame	ENST00000316626	ENST00000371477	GSK3B	chr3	119812193	-	CDC5L	chr6	44413391	+
intron-3CDS	ENST00000473886	ENST00000371477	GSK3B	chr3	119812193	-	CDC5L	chr6	44413391	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000264235

GSK3B

chr3

119812193

ENST00000371477

CDC5L

chr6

44413391

5104

1071

642

214

ENST00000316626

GSK3B

chr3

119812193

ENST00000371477

CDC5L

chr6

44413391

4353

320

335

637

100

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264235	ENST00000371477	GSK3B	chr3	119812193	-	CDC5L	chr6	44413391	+	0.041964263	0.95803577
ENST00000316626	ENST00000371477	GSK3B	chr3	119812193	-	CDC5L	chr6	44413391	+	0.05720208	0.94279796

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Fusion Genomic Features for GSK3B-CDC5L

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GSK3B	chr3	119812193	-	CDC5L	chr6	44413391	+	0.000273483	0.9997265
GSK3B	chr3	119812193	-	CDC5L	chr6	44413391	+	0.000273483	0.9997265

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GSK3B-CDC5L

Go to
FGviewer for the breakpoints of chr3:119812193-chr6:44413391
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CDC5L Q99459
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28502770, PubMed:28076346, PubMed:29361316, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). {ECO:0000269\|PubMed:10570151, ECO:0000269\|PubMed:11082045, ECO:0000269\|PubMed:11101529, ECO:0000269\|PubMed:11544257, ECO:0000269\|PubMed:11991638, ECO:0000269\|PubMed:12927788, ECO:0000269\|PubMed:18583928, ECO:0000269\|PubMed:20176811, ECO:0000269\|PubMed:24332808, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30705154, ECO:0000269\|PubMed:30728453, ECO:0000269\|PubMed:9038199, ECO:0000269\|PubMed:9468527, ECO:0000269\|PubMed:9632794}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CDC5L

chr3:119812193

chr6:44413391

ENST00000371477

764_802

697.0

803.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GSK3B

chr3:119812193

chr6:44413391

ENST00000264235

56_340

29.333333333333332

421.0

Domain

Protein kinase

Hgene

GSK3B

chr3:119812193

chr6:44413391

ENST00000316626

56_340

29.333333333333332

434.0

Domain

Protein kinase

Hgene

GSK3B

chr3:119812193

chr6:44413391

ENST00000264235

62_70

29.333333333333332

421.0

Nucleotide binding

ATP

Hgene

GSK3B

chr3:119812193

chr6:44413391

ENST00000316626

62_70

29.333333333333332

434.0

Nucleotide binding

ATP

Tgene

CDC5L

chr3:119812193

chr6:44413391

ENST00000371477

142_245

697.0

803.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CDC5L

chr3:119812193

chr6:44413391

ENST00000371477

676_701

697.0

803.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CDC5L

chr3:119812193

chr6:44413391

ENST00000371477

31_54

697.0

803.0

DNA binding

H-T-H motif

Tgene

CDC5L

chr3:119812193

chr6:44413391

ENST00000371477

82_104

697.0

803.0

DNA binding

H-T-H motif

Tgene

CDC5L

chr3:119812193

chr6:44413391

ENST00000371477

1_56

697.0

803.0

Domain

HTH myb-type 1

Tgene

CDC5L

chr3:119812193

chr6:44413391

ENST00000371477

57_108

697.0

803.0

Domain

HTH myb-type 2

Tgene

CDC5L

chr3:119812193

chr6:44413391

ENST00000371477

165_271

697.0

803.0

Motif

Nuclear localization signal

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Fusion Gene Sequence for GSK3B-CDC5L

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000264235_ENST00000371477_TCGA-HU-A4H6_GSK3B_chr3_119812193_-_CDC5L_chr6_44413391_length(transcript)=5104nt_BP=1071nt
CGGGCTTGTGCCGCCGCCGCCGCCGCCGCCGCCCGGGCCAAGTGACAAAGGAAGGAAGGAAGCGAGGAGGAGCCGGCCCCGCAGCCGCTG
ACAGGGCTCTGGGCTGGGGCAAAGCGCGGACACTTCCTGAGCGGGCACCGAGCAGAGCCGAGGGGCGGGAGGGCGGCCGAGCTGTTGCCG
CGGACGGGGGAGGGGGCCCCGAGGGACGGAAGCGGTTGCCGGGTTCCCATGTCCCCGGCGAATGGGGAACAGTCGAGGAGCCGCTGCCTG
GGGTCTGAAGGGAGCTGCCTCCGCCACCGCCATGGCCGCTGGATCCAGCCGCCGCCTGCAGCTGCTCCTGGCGCAATGAGGAGAGGAGCC
GCCGCCACCGCCACCGCCCGCCTCTGACTGACTCGCGACTCCGCCGCCCTCTAGTTCGCCGGGCCCCTGCCGTCAGCCCGCCGGATCCCG
CGGCTTGCCGGAGCTGCAGCGTTTCCCGTCGCATCTCCGAGCCACCCCCTCCCTCCCTCTCCCTCCCTCCTACCCATCCCCCTTTCTCTT
CAAGCGTGAGACTCGTGATCCTTCCGCCGCTTCCCTTCTTCATTGACTCGGAAAAAAAATCCCCGAGGAAAATATAATATTCGAAGTACT
CATTTTCAATCAAGTATTTGCCCCCGTTTCACGTGATACATATTTTTTTAGGATTTGCCCTCTCTTTTCTCTCCTCCCAGGAAAGGGAGG
GGAAAGAATTGTATTTTTTCCCAAGTCCTAAATCATCTATATGTTAAATATCCGTGCCGATCTGTCTTGAAGGAGAAATATATCGCTTGT
TTTGTTTTTTATAGTATACAAAAGGAGTGAAAAGCCAAGAGGACGAAGTCTTTTTCTTTTTCTTCTGTGGGAGAACTTAATGCTGCATTT
ATCGTTAACCTAACACCCCAACATAAAGACAAAAGGAAGAAAAGGAGGAAGGAAGGAAAAGGTGATTCGCGAAGAGAGTGATCATGTCAG
GGCGGCCCAGAACCACCTCCTTTGCGGAGAGCTGCAAGCCGGTGCAGCAGCCTTCAGCTTTTGGCAGCATGAAAGTTAGCAATAAACAGG
GGTCACATGACGACAGAAGCCAAGAGGGCTGCAAAGATGGAAAAGAAGATGAAAATTTTGCTTGGGGGTTACCAGTCTCGTGCTATGGGG
CTCATGAAACAGTTGAATGACTTATGGGACCAAATTGAACAGGCTCACTTGGAGTTACGCACTTTTGAAGAACTCAAGAAACATGAAGAT
TCTGCTATTCCCCGGAGGCTAGAGTGTCTAAAAGAAGACGTTCAGCGACAACAAGAAAGAGAAAAGGAACTTCAACATAGATATGCTGAT
TTGCTGCTGGAGAAAGAGACTTTAAAGTCAAAATTCTGAAGTACAGTTTATATTCTGTCACAGGATTAATTAATTGCCGGTTTTCATACT
CTAGAAGGCTGAAACTGATGTTTATCTTCATTGACAAATTTACCCACCATCTGTGGTTTTTCAGTTGTTTATTTTAAATGATATCGATCT
TACACATTCTGTGTATAAAGACCTTAACTCCACAGGACGGACATTTTAGAGTTTAAATTATTAAGGCTATCATTCTTTTAGTAATGTCAT
ATTTGCAAACTTTTTTAGTTTTGGCCTTTAATTTAAAAAGCCTAATTTTAAAGTGCTGCCTGTGAGTAACTCTTGAATAAAAACAAAATA
TAAAAAATTGAGAATGTAGCCTTTTGTTTGAAGTAATTAGATACTTAAGAGTGCCTGCAAACCAGCAGCTATGTACTCTGTGTCATATTT
AATGAGTAACTCTTGGGTAATCAAAATGGTGATGCAGTATCTTAAACACTTAAGAGGCAGTTCTTTGTGGCTTTGTTAGTTTCAGCAAAG
AGTGGTCATTTCTGTATACACTGACAAGTTAGATTAACTTTTTAGTACCTCAAATTTTTTTTTTGTTAATATCACTTTAAAGAAGGTCTC
TTGTCTGCCAGCTACTTAAATAATTTATGGGTCAGGGCTTAAAAGATTTAACTTCCTTGCCCCATTATTTTCTTATAAGTATTTTTTGAC
AAAGGCATTTTAAAAGTTAATTTCAAGAAGGCCATCAAACTTAAAGCTCTATGTTTAGCCTAAGAAGTCAGTTACATCAGTGTAGAATTT
GGGGAATGGATAGAGGTGGAGATATTTAATTTTATATAATTCATATAAATTGATTTAGTTACAGTATCAGTTGGCTACAAGCTCATTATA
GACTAGCAATGTTTTGACATCACCAAAAACGTTTGCCCAGTCTTAGAATACTAGGGACTATAGGAAGGGAAGGGATTCATTCATTCATTC
GATATTGAATGTATACCCTGTGCCAGAGTCTTAGAGAGAGAACAACAAACAAAATAGGCCTAGTTCTTGTTTAGTAGAGCTTATAGTCTT
TTGAGAATGACAGACAATTAAAATCCAAATGTTTATTTGGTGATTCTTATGTGTCAGACACTTAAGTGTTGGGAGATAAGCAGTTATTAA
GACAGAGTTCTTGCTCTCATGGAGGTGACATTAGTGGGGAGGAGATACTAAGTATGTCCAGGGAAAGTATCAGACCATGAGTTTTAGATT
CTGTGGAGGAAATTAAAGTAGGGTGATTATGAGATAGTGAATGAGTGGCTATTTTAGACTGGACGATCAAAGAGACCTCTTGGAAGGCAG
CTATGCTCACCACTATACCACTGCACTGTGCCGCACCGTACCACTATAAGCTGCACGGCCAAAGAGACCTCTTAAAGAAGTAACATTTAA
GATAACATGTGATTGACATTTTAGAATGGGCTATCCTTGTGAGATTCAAGGAAAGAACATCCTAGGTGGAGTGAATAGCAAACATAAAGC
CTCTTTTGTATGTTTGAGGAACAAAAAGGACAATGCAGCTAGAGTGTCAAGAATGGCATTTCTGTATATAAGACCTCGTTGTATAGAGCC
ACATAAATAAGGCTATAATAAGGAATTTGGATCTTACTTTAAATATGATAAGAATCGATGAGAAGATCTAAGCAAAGGAATGACATGATC
AGATTTGGTTTTAGAAACATCACTATCTCCTTAGTGTGTAAAATCTCACCAGGCTGGAGATAGGGAAGCCAGTCCAATTAGGAGCCTGAT
GCAGTGATCCAGACAAAAAAATAATAGTGATTCTAACTAGAGTCCAGGTAATAGTAGTGGAGATATGTGGAGAGACATGATAGGTATATA
CTTAATAGTCTTATCAGACGATAAATTGATATTTTCCTGGTGTGTAGTCACTTAATTCAAATACTTTTTTCAGTAAGTTCTGGGTTTTCT
AGGAAAAACTTCAGTATCATCAGTGAATAATGATAGTGTTTCTTCTGATAGTTTTATTTCACTTTTATTGCATGTTTTGTTATCTGAAAT
GTTTAGGACAATGTTAACAATAATGATGTTAGACATTTTTTTTTCTTATTTTAATGGGAATGTCCATAGTTTTAAGTTTGCTGTTGGGAG
TTAGATAGTCTTTATCTGAAAGACAGTGTCTCTCTTTTAGTTTTTAAAGAGTTTGAATTAGAAATGGCTCTGGAACTTTAAACAGTATAC
CATTTGGGCATCTATTAAAGCATTCATATAATTGTTCTCATTTGATGTTTTGATGAGGTATATTAATAGATTTTCCCACATTAAATCATC
TTTGCACTCCTGGAATCAGGTAGATTAATTTTTAAAAGAAATTTTAAAGGATTTATAGTTTATTTGCACTTTTTGTAGACTTGAATTATA
TGGATTTAAAAGTTGATCTAATATTAATAAAGGCTCACTTTGTTTTCAAAATTTGAAGTAATTCACATACTTATAGCCTAAAAAAATCGG
CAGGAATTACAAAATTTCAAAACTGGCACATTGTAAACTGCATATGCATTTGCCAGGTAGTGGTGCCACTTGAAATGGTGAACAGACACA
CTGTTATCCTTTGTCAGTATCCTGTAAAGCCCAGGATTCTTTACCAGCACCATACAGCGATTTTGGTGACTATTTTAACATTCACACTGA
GGCCAGGGGTGGTGAGTCATGCCTGTAATCCTAGCACTTTGGGAGGCCAAGGTGGGAGGATCATTTGAGCTCAGGAGTTCAAGATTAGCC
TGGGTAACATAGTGAGACCCTGTCTCTATTAAAAAATAATAATAAAAATAACATTCACATTGGTATTGTTCACTAAGGTATTGGTTGTTA
AGGCATTCATTAAGGTATTGTTAAAACTTGTGTTAAGCATGTTAAAGTCTCAGTAACTTTGGGATAGAAATAAAATGTGATAAAAAGCTG
AAAGAAACCACCACAAGGGAGAGTCCTTTTTGAAATATTAGAGACATAATGCTGTCTAATAAAAAACGACATCAAAGAAAAACTACACTA
CAGTGACTGCAGACTTAATGTTGGCCAACCATGCATCCTCCCTAGAAATGCATTTGAATTTGATTTACTAATCTTTTATTTAGGAAATTT
ACATTTTTACATTAGTGAGATTGGTCTTTTGGGCTATTGTACTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTCTCACCCAGGCT
GGAGTGCAGTAGTGCAATCTTGGCCCACTGCAACCTCTGCCTCCTGGGCTCGAGTGATTCTCTGCCTCAGCCTTCCAAGTAGCTGGGACT
ACAGGCATGTGCCACCGCACCTGGCTAATTTTTGTGTTTTTAGTAGAGATGGGGTTTTGCTATGTTGGCCAGGCTGGTCTTGAATTCCTG
ACCTCAGGTGATCCACCTACCTCGGCCTCCCAAAGTGCTAGAATTACAGGTGTGAGCCACCATGCCCAGCCTGGTTATTGTATTTTGATA
TTGGGATTTTGCTAGCTCTCTAAAGTAAATAGGATAACTGTATATCTTTTTCTGTGCATTAAGCAGTTATAACATGGGAATGATTTGTTC
ATGAAAGGTTGAAAGTCTGTACTTACAGAACTTTTGAGTTCACAGTGCTTTCTGGAAATAATTTCTTTATAACTGTCAGTTTCTTTTGTG

>In-frame_ENST00000264235_ENST00000371477_TCGA-HU-A4H6_GSK3B_chr3_119812193_-_CDC5L_chr6_44413391_length(amino acids)=214AA_start in transcript=642_stop in transcript=1
MIENEYFEYYIFLGDFFSESMKKGSGGRITSLTLEEKGGWVGGREREGGGGSEMRRETLQLRQAAGSGGLTAGARRTRGRRSRESVRGGR
WRWRRLLSSLRQEQLQAAAGSSGHGGGGGSSLQTPGSGSSTVPHSPGTWEPGNRFRPSGPPPPSAATARPPSRPSALLGARSGSVRALPQ

--------------------------------------------------------------
>In-frame_ENST00000316626_ENST00000371477_TCGA-HU-A4H6_GSK3B_chr3_119812193_-_CDC5L_chr6_44413391_length(transcript)=4353nt_BP=320nt
ATCATCTATATGTTAAATATCCGTGCCGATCTGTCTTGAAGGAGAAATATATCGCTTGTTTTGTTTTTTATAGTATACAAAAGGAGTGAA
AAGCCAAGAGGACGAAGTCTTTTTCTTTTTCTTCTGTGGGAGAACTTAATGCTGCATTTATCGTTAACCTAACACCCCAACATAAAGACA
AAAGGAAGAAAAGGAGGAAGGAAGGAAAAGGTGATTCGCGAAGAGAGTGATCATGTCAGGGCGGCCCAGAACCACCTCCTTTGCGGAGAG
CTGCAAGCCGGTGCAGCAGCCTTCAGCTTTTGGCAGCATGAAAGTTAGCAATAAACAGGGGTCACATGACGACAGAAGCCAAGAGGGCTG
CAAAGATGGAAAAGAAGATGAAAATTTTGCTTGGGGGTTACCAGTCTCGTGCTATGGGGCTCATGAAACAGTTGAATGACTTATGGGACC
AAATTGAACAGGCTCACTTGGAGTTACGCACTTTTGAAGAACTCAAGAAACATGAAGATTCTGCTATTCCCCGGAGGCTAGAGTGTCTAA
AAGAAGACGTTCAGCGACAACAAGAAAGAGAAAAGGAACTTCAACATAGATATGCTGATTTGCTGCTGGAGAAAGAGACTTTAAAGTCAA
AATTCTGAAGTACAGTTTATATTCTGTCACAGGATTAATTAATTGCCGGTTTTCATACTCTAGAAGGCTGAAACTGATGTTTATCTTCAT
TGACAAATTTACCCACCATCTGTGGTTTTTCAGTTGTTTATTTTAAATGATATCGATCTTACACATTCTGTGTATAAAGACCTTAACTCC
ACAGGACGGACATTTTAGAGTTTAAATTATTAAGGCTATCATTCTTTTAGTAATGTCATATTTGCAAACTTTTTTAGTTTTGGCCTTTAA
TTTAAAAAGCCTAATTTTAAAGTGCTGCCTGTGAGTAACTCTTGAATAAAAACAAAATATAAAAAATTGAGAATGTAGCCTTTTGTTTGA
AGTAATTAGATACTTAAGAGTGCCTGCAAACCAGCAGCTATGTACTCTGTGTCATATTTAATGAGTAACTCTTGGGTAATCAAAATGGTG
ATGCAGTATCTTAAACACTTAAGAGGCAGTTCTTTGTGGCTTTGTTAGTTTCAGCAAAGAGTGGTCATTTCTGTATACACTGACAAGTTA
GATTAACTTTTTAGTACCTCAAATTTTTTTTTTGTTAATATCACTTTAAAGAAGGTCTCTTGTCTGCCAGCTACTTAAATAATTTATGGG
TCAGGGCTTAAAAGATTTAACTTCCTTGCCCCATTATTTTCTTATAAGTATTTTTTGACAAAGGCATTTTAAAAGTTAATTTCAAGAAGG
CCATCAAACTTAAAGCTCTATGTTTAGCCTAAGAAGTCAGTTACATCAGTGTAGAATTTGGGGAATGGATAGAGGTGGAGATATTTAATT
TTATATAATTCATATAAATTGATTTAGTTACAGTATCAGTTGGCTACAAGCTCATTATAGACTAGCAATGTTTTGACATCACCAAAAACG
TTTGCCCAGTCTTAGAATACTAGGGACTATAGGAAGGGAAGGGATTCATTCATTCATTCGATATTGAATGTATACCCTGTGCCAGAGTCT
TAGAGAGAGAACAACAAACAAAATAGGCCTAGTTCTTGTTTAGTAGAGCTTATAGTCTTTTGAGAATGACAGACAATTAAAATCCAAATG
TTTATTTGGTGATTCTTATGTGTCAGACACTTAAGTGTTGGGAGATAAGCAGTTATTAAGACAGAGTTCTTGCTCTCATGGAGGTGACAT
TAGTGGGGAGGAGATACTAAGTATGTCCAGGGAAAGTATCAGACCATGAGTTTTAGATTCTGTGGAGGAAATTAAAGTAGGGTGATTATG
AGATAGTGAATGAGTGGCTATTTTAGACTGGACGATCAAAGAGACCTCTTGGAAGGCAGCTATGCTCACCACTATACCACTGCACTGTGC
CGCACCGTACCACTATAAGCTGCACGGCCAAAGAGACCTCTTAAAGAAGTAACATTTAAGATAACATGTGATTGACATTTTAGAATGGGC
TATCCTTGTGAGATTCAAGGAAAGAACATCCTAGGTGGAGTGAATAGCAAACATAAAGCCTCTTTTGTATGTTTGAGGAACAAAAAGGAC
AATGCAGCTAGAGTGTCAAGAATGGCATTTCTGTATATAAGACCTCGTTGTATAGAGCCACATAAATAAGGCTATAATAAGGAATTTGGA
TCTTACTTTAAATATGATAAGAATCGATGAGAAGATCTAAGCAAAGGAATGACATGATCAGATTTGGTTTTAGAAACATCACTATCTCCT
TAGTGTGTAAAATCTCACCAGGCTGGAGATAGGGAAGCCAGTCCAATTAGGAGCCTGATGCAGTGATCCAGACAAAAAAATAATAGTGAT
TCTAACTAGAGTCCAGGTAATAGTAGTGGAGATATGTGGAGAGACATGATAGGTATATACTTAATAGTCTTATCAGACGATAAATTGATA
TTTTCCTGGTGTGTAGTCACTTAATTCAAATACTTTTTTCAGTAAGTTCTGGGTTTTCTAGGAAAAACTTCAGTATCATCAGTGAATAAT
GATAGTGTTTCTTCTGATAGTTTTATTTCACTTTTATTGCATGTTTTGTTATCTGAAATGTTTAGGACAATGTTAACAATAATGATGTTA
GACATTTTTTTTTCTTATTTTAATGGGAATGTCCATAGTTTTAAGTTTGCTGTTGGGAGTTAGATAGTCTTTATCTGAAAGACAGTGTCT
CTCTTTTAGTTTTTAAAGAGTTTGAATTAGAAATGGCTCTGGAACTTTAAACAGTATACCATTTGGGCATCTATTAAAGCATTCATATAA
TTGTTCTCATTTGATGTTTTGATGAGGTATATTAATAGATTTTCCCACATTAAATCATCTTTGCACTCCTGGAATCAGGTAGATTAATTT
TTAAAAGAAATTTTAAAGGATTTATAGTTTATTTGCACTTTTTGTAGACTTGAATTATATGGATTTAAAAGTTGATCTAATATTAATAAA
GGCTCACTTTGTTTTCAAAATTTGAAGTAATTCACATACTTATAGCCTAAAAAAATCGGCAGGAATTACAAAATTTCAAAACTGGCACAT
TGTAAACTGCATATGCATTTGCCAGGTAGTGGTGCCACTTGAAATGGTGAACAGACACACTGTTATCCTTTGTCAGTATCCTGTAAAGCC
CAGGATTCTTTACCAGCACCATACAGCGATTTTGGTGACTATTTTAACATTCACACTGAGGCCAGGGGTGGTGAGTCATGCCTGTAATCC
TAGCACTTTGGGAGGCCAAGGTGGGAGGATCATTTGAGCTCAGGAGTTCAAGATTAGCCTGGGTAACATAGTGAGACCCTGTCTCTATTA
AAAAATAATAATAAAAATAACATTCACATTGGTATTGTTCACTAAGGTATTGGTTGTTAAGGCATTCATTAAGGTATTGTTAAAACTTGT
GTTAAGCATGTTAAAGTCTCAGTAACTTTGGGATAGAAATAAAATGTGATAAAAAGCTGAAAGAAACCACCACAAGGGAGAGTCCTTTTT
GAAATATTAGAGACATAATGCTGTCTAATAAAAAACGACATCAAAGAAAAACTACACTACAGTGACTGCAGACTTAATGTTGGCCAACCA
TGCATCCTCCCTAGAAATGCATTTGAATTTGATTTACTAATCTTTTATTTAGGAAATTTACATTTTTACATTAGTGAGATTGGTCTTTTG
GGCTATTGTACTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTCTCACCCAGGCTGGAGTGCAGTAGTGCAATCTTGGCCCACTGC
AACCTCTGCCTCCTGGGCTCGAGTGATTCTCTGCCTCAGCCTTCCAAGTAGCTGGGACTACAGGCATGTGCCACCGCACCTGGCTAATTT
TTGTGTTTTTAGTAGAGATGGGGTTTTGCTATGTTGGCCAGGCTGGTCTTGAATTCCTGACCTCAGGTGATCCACCTACCTCGGCCTCCC
AAAGTGCTAGAATTACAGGTGTGAGCCACCATGCCCAGCCTGGTTATTGTATTTTGATATTGGGATTTTGCTAGCTCTCTAAAGTAAATA
GGATAACTGTATATCTTTTTCTGTGCATTAAGCAGTTATAACATGGGAATGATTTGTTCATGAAAGGTTGAAAGTCTGTACTTACAGAAC
TTTTGAGTTCACAGTGCTTTCTGGAAATAATTTCTTTATAACTGTCAGTTTCTTTTGTGACTATTATGTTACCTATTTTTAAATTTAAGC

>In-frame_ENST00000316626_ENST00000371477_TCGA-HU-A4H6_GSK3B_chr3_119812193_-_CDC5L_chr6_44413391_length(amino acids)=100AA_start in transcript=335_stop in transcript=637
MTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQEREKELQHRYADLL

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Fusion Gene PPI Analysis for GSK3B-CDC5L

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	CDC5L	chr3:119812193	chr6:44413391	ENST00000371477		13	16	706_800	697.0	803.0	PLRG1

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	CDC5L	chr3:119812193	chr6:44413391	ENST00000371477		13	16	501_659	697.0	803.0	DAPK3
Tgene	CDC5L	chr3:119812193	chr6:44413391	ENST00000371477		13	16	260_606	697.0	803.0	PPP1R8

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for GSK3B-CDC5L

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GSK3B-CDC5L

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	GSK3B	C0005586	Bipolar Disorder	6	CTD_human;PSYGENET
Hgene	GSK3B	C0011581	Depressive disorder	5	CTD_human;PSYGENET
Hgene	GSK3B	C1269683	Major Depressive Disorder	5	PSYGENET
Hgene	GSK3B	C0011570	Mental Depression	3	PSYGENET
Hgene	GSK3B	C0002395	Alzheimer's Disease	2	CTD_human
Hgene	GSK3B	C0011265	Presenile dementia	2	CTD_human
Hgene	GSK3B	C0011573	Endogenous depression	2	CTD_human
Hgene	GSK3B	C0025193	Melancholia	2	CTD_human
Hgene	GSK3B	C0033578	Prostatic Neoplasms	2	CTD_human
Hgene	GSK3B	C0036341	Schizophrenia	2	CTD_human
Hgene	GSK3B	C0041696	Unipolar Depression	2	CTD_human
Hgene	GSK3B	C0086133	Depressive Syndrome	2	CTD_human
Hgene	GSK3B	C0276496	Familial Alzheimer Disease (FAD)	2	CTD_human
Hgene	GSK3B	C0282126	Depression, Neurotic	2	CTD_human
Hgene	GSK3B	C0376358	Malignant neoplasm of prostate	2	CTD_human
Hgene	GSK3B	C0494463	Alzheimer Disease, Late Onset	2	CTD_human
Hgene	GSK3B	C0525045	Mood Disorders	2	PSYGENET
Hgene	GSK3B	C0546126	Acute Confusional Senile Dementia	2	CTD_human
Hgene	GSK3B	C0750900	Alzheimer's Disease, Focal Onset	2	CTD_human
Hgene	GSK3B	C0750901	Alzheimer Disease, Early Onset	2	CTD_human
Hgene	GSK3B	C0000772	Multiple congenital anomalies	1	CTD_human
Hgene	GSK3B	C0003865	Arthritis, Adjuvant-Induced	1	CTD_human
Hgene	GSK3B	C0005587	Depression, Bipolar	1	CTD_human
Hgene	GSK3B	C0007621	Neoplastic Cell Transformation	1	CTD_human
Hgene	GSK3B	C0009241	Cognition Disorders	1	CTD_human
Hgene	GSK3B	C0018800	Cardiomegaly	1	CTD_human
Hgene	GSK3B	C0018801	Heart failure	1	CTD_human
Hgene	GSK3B	C0018802	Congestive heart failure	1	CTD_human
Hgene	GSK3B	C0020538	Hypertensive disease	1	CTD_human
Hgene	GSK3B	C0022660	Kidney Failure, Acute	1	CTD_human
Hgene	GSK3B	C0023212	Left-Sided Heart Failure	1	CTD_human
Hgene	GSK3B	C0024713	Manic Disorder	1	CTD_human
Hgene	GSK3B	C0026846	Muscular Atrophy	1	CTD_human
Hgene	GSK3B	C0027051	Myocardial Infarction	1	CTD_human
Hgene	GSK3B	C0031154	Peritonitis	1	CTD_human
Hgene	GSK3B	C0235527	Heart Failure, Right-Sided	1	CTD_human
Hgene	GSK3B	C0270948	Neurogenic Muscular Atrophy	1	CTD_human
Hgene	GSK3B	C0334634	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	1	CTD_human
Hgene	GSK3B	C0338831	Manic	1	CTD_human
Hgene	GSK3B	C0751958	Lymphoma, Lymphocytic, Intermediate	1	CTD_human
Hgene	GSK3B	C0949664	Tauopathies	1	CTD_human
Hgene	GSK3B	C0971858	Arthritis, Collagen-Induced	1	CTD_human
Hgene	GSK3B	C0993582	Arthritis, Experimental	1	CTD_human
Hgene	GSK3B	C1383860	Cardiac Hypertrophy	1	CTD_human
Hgene	GSK3B	C1449646	Primary Peritonitis	1	CTD_human
Hgene	GSK3B	C1449647	Secondary Peritonitis	1	CTD_human
Hgene	GSK3B	C1565662	Acute Kidney Insufficiency	1	CTD_human
Hgene	GSK3B	C1866282	CEROID LIPOFUSCINOSIS, NEURONAL, 6	1	CTD_human
Hgene	GSK3B	C1959583	Myocardial Failure	1	CTD_human
Hgene	GSK3B	C1961112	Heart Decompensation	1	CTD_human
Hgene	GSK3B	C2609414	Acute kidney injury	1	CTD_human