|
Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:GSK3B-SMAP1 (FusionGDB2 ID:34928) |
Fusion Gene Summary for GSK3B-SMAP1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: GSK3B-SMAP1 | Fusion gene ID: 34928 | Hgene | Tgene | Gene symbol | GSK3B | SMAP1 | Gene ID | 2932 | 60682 |
Gene name | glycogen synthase kinase 3 beta | small ArfGAP 1 | |
Synonyms | - | SMAP-1 | |
Cytomap | 3q13.33 | 6q13 | |
Type of gene | protein-coding | protein-coding | |
Description | glycogen synthase kinase-3 betaGSK-3 betaGSK3beta isoformserine/threonine-protein kinase GSK3B | stromal membrane-associated protein 1stromal membrane-associated GTPase-activating protein 1 | |
Modification date | 20200315 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000264235, ENST00000316626, ENST00000473886, | ENST00000316999, ENST00000370452, ENST00000370455, ENST00000422334, | |
Fusion gene scores | * DoF score | 31 X 22 X 12=8184 | 9 X 7 X 6=378 |
# samples | 36 | 9 | |
** MAII score | log2(36/8184*10)=-4.50673733341565 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GSK3B [Title/Abstract] AND SMAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | GSK3B(119720892)-SMAP1(71508359), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GSK3B | GO:0005977 | glycogen metabolic process | 8638126 |
Hgene | GSK3B | GO:0006468 | protein phosphorylation | 11035810|16315267|20937854 |
Hgene | GSK3B | GO:0006983 | ER overload response | 14744935 |
Hgene | GSK3B | GO:0018105 | peptidyl-serine phosphorylation | 8638126|11104755|11955436|14744935|17139249 |
Hgene | GSK3B | GO:0018107 | peptidyl-threonine phosphorylation | 11955436|17139249|25897075 |
Hgene | GSK3B | GO:0031175 | neuron projection development | 19830702 |
Hgene | GSK3B | GO:0031334 | positive regulation of protein complex assembly | 8638126 |
Hgene | GSK3B | GO:0032091 | negative regulation of protein binding | 16890161 |
Hgene | GSK3B | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 19364825 |
Hgene | GSK3B | GO:0035556 | intracellular signal transduction | 14749367 |
Hgene | GSK3B | GO:0043066 | negative regulation of apoptotic process | 14744935 |
Hgene | GSK3B | GO:0046777 | protein autophosphorylation | 23184662 |
Hgene | GSK3B | GO:0046827 | positive regulation of protein export from nucleus | 14744935 |
Hgene | GSK3B | GO:1901215 | negative regulation of neuron death | 19830702 |
Hgene | GSK3B | GO:1901216 | positive regulation of neuron death | 18508033 |
Hgene | GSK3B | GO:2000300 | regulation of synaptic vesicle exocytosis | 17989287 |
Fusion gene breakpoints across GSK3B (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across SMAP1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-RD-A8N9 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + |
Top |
Fusion Gene ORF analysis for GSK3B-SMAP1 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000264235 | ENST00000316999 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + |
In-frame | ENST00000264235 | ENST00000370452 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + |
In-frame | ENST00000264235 | ENST00000370455 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + |
5CDS-intron | ENST00000264235 | ENST00000422334 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + |
In-frame | ENST00000316626 | ENST00000316999 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + |
In-frame | ENST00000316626 | ENST00000370452 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + |
In-frame | ENST00000316626 | ENST00000370455 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + |
5CDS-intron | ENST00000316626 | ENST00000422334 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + |
intron-3CDS | ENST00000473886 | ENST00000316999 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + |
intron-3CDS | ENST00000473886 | ENST00000370452 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + |
intron-3CDS | ENST00000473886 | ENST00000370455 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + |
intron-intron | ENST00000473886 | ENST00000422334 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000264235 | GSK3B | chr3 | 119720892 | - | ENST00000316999 | SMAP1 | chr6 | 71508359 | + | 3006 | 1265 | 983 | 2173 | 396 |
ENST00000264235 | GSK3B | chr3 | 119720892 | - | ENST00000370452 | SMAP1 | chr6 | 71508359 | + | 3094 | 1265 | 983 | 2161 | 392 |
ENST00000264235 | GSK3B | chr3 | 119720892 | - | ENST00000370455 | SMAP1 | chr6 | 71508359 | + | 3855 | 1265 | 983 | 2173 | 396 |
ENST00000316626 | GSK3B | chr3 | 119720892 | - | ENST00000316999 | SMAP1 | chr6 | 71508359 | + | 2255 | 514 | 232 | 1422 | 396 |
ENST00000316626 | GSK3B | chr3 | 119720892 | - | ENST00000370452 | SMAP1 | chr6 | 71508359 | + | 2343 | 514 | 232 | 1410 | 392 |
ENST00000316626 | GSK3B | chr3 | 119720892 | - | ENST00000370455 | SMAP1 | chr6 | 71508359 | + | 3104 | 514 | 232 | 1422 | 396 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000264235 | ENST00000316999 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + | 0.002676967 | 0.9973231 |
ENST00000264235 | ENST00000370452 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + | 0.002143231 | 0.9978568 |
ENST00000264235 | ENST00000370455 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + | 0.001452332 | 0.9985476 |
ENST00000316626 | ENST00000316999 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + | 0.001821632 | 0.99817836 |
ENST00000316626 | ENST00000370452 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + | 0.001624762 | 0.9983752 |
ENST00000316626 | ENST00000370455 | GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + | 0.000974143 | 0.9990258 |
Top |
Fusion Genomic Features for GSK3B-SMAP1 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + | 3.72E-05 | 0.9999628 |
GSK3B | chr3 | 119720892 | - | SMAP1 | chr6 | 71508359 | + | 3.72E-05 | 0.9999628 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for GSK3B-SMAP1 |
Go to FGviewer for the breakpoints of chr3:119720892-chr6:71508359 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | GSK3B | chr3:119720892 | chr6:71508359 | ENST00000264235 | - | 2 | 11 | 62_70 | 94.0 | 421.0 | Nucleotide binding | ATP |
Hgene | GSK3B | chr3:119720892 | chr6:71508359 | ENST00000316626 | - | 2 | 12 | 62_70 | 94.0 | 434.0 | Nucleotide binding | ATP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | GSK3B | chr3:119720892 | chr6:71508359 | ENST00000264235 | - | 2 | 11 | 56_340 | 94.0 | 421.0 | Domain | Protein kinase |
Hgene | GSK3B | chr3:119720892 | chr6:71508359 | ENST00000316626 | - | 2 | 12 | 56_340 | 94.0 | 434.0 | Domain | Protein kinase |
Tgene | SMAP1 | chr3:119720892 | chr6:71508359 | ENST00000316999 | 3 | 10 | 18_136 | 138.0 | 441.0 | Domain | Arf-GAP | |
Tgene | SMAP1 | chr3:119720892 | chr6:71508359 | ENST00000370452 | 3 | 11 | 18_136 | 138.0 | 437.0 | Domain | Arf-GAP | |
Tgene | SMAP1 | chr3:119720892 | chr6:71508359 | ENST00000370455 | 4 | 11 | 18_136 | 165.0 | 468.0 | Domain | Arf-GAP | |
Tgene | SMAP1 | chr3:119720892 | chr6:71508359 | ENST00000316999 | 3 | 10 | 33_56 | 138.0 | 441.0 | Zinc finger | C4-type | |
Tgene | SMAP1 | chr3:119720892 | chr6:71508359 | ENST00000370452 | 3 | 11 | 33_56 | 138.0 | 437.0 | Zinc finger | C4-type | |
Tgene | SMAP1 | chr3:119720892 | chr6:71508359 | ENST00000370455 | 4 | 11 | 33_56 | 165.0 | 468.0 | Zinc finger | C4-type |
Top |
Fusion Gene Sequence for GSK3B-SMAP1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000264235_ENST00000316999_TCGA-RD-A8N9_GSK3B_chr3_119720892_-_SMAP1_chr6_71508359_length(transcript)=3006nt_BP=1265nt CGGGCTTGTGCCGCCGCCGCCGCCGCCGCCGCCCGGGCCAAGTGACAAAGGAAGGAAGGAAGCGAGGAGGAGCCGGCCCCGCAGCCGCTG ACAGGGCTCTGGGCTGGGGCAAAGCGCGGACACTTCCTGAGCGGGCACCGAGCAGAGCCGAGGGGCGGGAGGGCGGCCGAGCTGTTGCCG CGGACGGGGGAGGGGGCCCCGAGGGACGGAAGCGGTTGCCGGGTTCCCATGTCCCCGGCGAATGGGGAACAGTCGAGGAGCCGCTGCCTG GGGTCTGAAGGGAGCTGCCTCCGCCACCGCCATGGCCGCTGGATCCAGCCGCCGCCTGCAGCTGCTCCTGGCGCAATGAGGAGAGGAGCC GCCGCCACCGCCACCGCCCGCCTCTGACTGACTCGCGACTCCGCCGCCCTCTAGTTCGCCGGGCCCCTGCCGTCAGCCCGCCGGATCCCG CGGCTTGCCGGAGCTGCAGCGTTTCCCGTCGCATCTCCGAGCCACCCCCTCCCTCCCTCTCCCTCCCTCCTACCCATCCCCCTTTCTCTT CAAGCGTGAGACTCGTGATCCTTCCGCCGCTTCCCTTCTTCATTGACTCGGAAAAAAAATCCCCGAGGAAAATATAATATTCGAAGTACT CATTTTCAATCAAGTATTTGCCCCCGTTTCACGTGATACATATTTTTTTAGGATTTGCCCTCTCTTTTCTCTCCTCCCAGGAAAGGGAGG GGAAAGAATTGTATTTTTTCCCAAGTCCTAAATCATCTATATGTTAAATATCCGTGCCGATCTGTCTTGAAGGAGAAATATATCGCTTGT TTTGTTTTTTATAGTATACAAAAGGAGTGAAAAGCCAAGAGGACGAAGTCTTTTTCTTTTTCTTCTGTGGGAGAACTTAATGCTGCATTT ATCGTTAACCTAACACCCCAACATAAAGACAAAAGGAAGAAAAGGAGGAAGGAAGGAAAAGGTGATTCGCGAAGAGAGTGATCATGTCAG GGCGGCCCAGAACCACCTCCTTTGCGGAGAGCTGCAAGCCGGTGCAGCAGCCTTCAGCTTTTGGCAGCATGAAAGTTAGCAGAGACAAGG ACGGCAGCAAGGTGACAACAGTGGTGGCAACTCCTGGGCAGGGTCCAGACAGGCCACAAGAAGTCAGCTATACAGACACTAAAGTGATTG GAAATGGATCATTTGGTGTGGTATATCAAGCCAAACTTTGTGATTCAGGAGAACTGGTCGCCATCAAGAAAGTATTGCAGGACAAGAGAT TTAAGAAAGAAAAGGAAAAAAAAAAGGAAGAGAAAAAGAGAGAAAAGGAGCCAGAAAAGCCGGCAAAACCACTTACAGCTGAAAAGCTGC AGAAGAAAGATCAGCAACTGGAGCCTAAAAAAAGTACCAGCCCTAAAAAAGCTGCGGAGCCCACTGTGGATCTTTTAGGACTTGATGGCC CTGCTGTGGCACCAGTGACCAACGGGAACACAACGGTGCCACCCCTGAACGATGATCTGGACATCTTTGGACCGATGATTTCTAATCCCT TACCTGCAACTGTCATGCCCCCAGCTCAGGGGACACCCTCTGCACCAGCAGCTGCAACCCTGTCTACAGTAACATCTGGGGATCTAGATT TATTCACTGAGCAAACTACAAAATCAGAAGAAGTGGCAAAGAAACAACTTTCCAAAGACTCCATCTTATCTCTGTATGGCACAGGAACCA TTCAACAGCAAAGTACTCCTGGTGTATTTATGGGACCCACAAATATACCATTTACCTCACAAGCACCAGCTGCATTTCAGGGCTTTCCAT CGATGGGCGTGCCTGTGCCTGCAGCTCCTGGCCTTATAGGAAATGTGATGGGACAGAGTCCAAGCATGATGGTGGGCATGCCCATGCCCA ATGGGTTTATGGGAAATGCACAAACTGGTGTGATGCCACTTCCTCAGAACGTTGTTGGCCCCCAAGGAGGAATGGTGGGACAAATGGGTG CACCCCAGAGTAAGTTTGGCCTGCCGCAAGCTCAGCAGCCCCAGTGGAGCCTCTCACAGATGAATCAGCAGATGGCTGGCATGAGTATCA GTAGTGCAACCCCTACTGCAGGTTTTGGCCAGCCCTCCAGCACAACAGCAGGATGGTCTGGAAGCTCATCAGGTCAGACTCTCAGCACAC AACTGTGGAAATGAAAACTGCAATACAAGTTTCATCCAGAACTACCACCTGACATTCCTTGCTGAAACGCATCTAGTTCCCCTGTTTATT CATATGCATATTTTTTTTCTTTTTACCCATTTGTTCATATTAAGAATGATCTGATTGACCGTGTTGGTCTGTACTGATTCAATTTGATGT GGTGAAAAGCAGGTTGATAAATCATTTTATGTCAAGGGCAGCTTTGCTCATATTTCCCATGATTTCATGTACTGCATTATTTGAGAAGCT GCTCAACTTGCAAAATCAGTTTTCCTCTCAATAAAATTATAGCTCTAATGTTTGCATATAAGGGAAGTAGTTATCATGTTAGTAATACCT CTAATAGTATAAACCCCACCCCAAAATTAGCCAGTAATCCTGTAGGAAGGTACTGTATGATCAAATGTTTAATCATATAAATAGAATGTA AATGTCTCACTGAGCACTGTTTTCTAGTGTATCAAAATGCTCTTATTTCATCATTCACTTCACTGTGCTGTTGTTATGATGTGCTTAACA GGGAACGTGATTAGTGAAAGGAAGATAAACGTGGATGTTACTCCAAAACTTCGTTTAATGAATGCTTAAAGAATTCAAATTTTATCTGCC TCTCTTGTAATTTGGATCTCTTCTTAATGTACATAGTGCTAACATGAAGACCTTTTTCTGCACTATATGCAAACAGGGTAACTAACTAAA ACAAAGCCACTTTCAATCTTCAATCCTTGAAGGTATATCTAGGTTTATGACAGTAATTGTGTTTACATTTTATGGTGCCTAGTATTGACA >In-frame_ENST00000264235_ENST00000316999_TCGA-RD-A8N9_GSK3B_chr3_119720892_-_SMAP1_chr6_71508359_length(amino acids)=396AA_start in transcript=983_stop in transcript=2173 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD KRFKKEKEKKKEEKKREKEPEKPAKPLTAEKLQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLNDDLDIFGPMIS NPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQQSTPGVFMGPTNIPFTSQAPAAFQG FPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWSLSQMNQQMAGM -------------------------------------------------------------- >In-frame_ENST00000264235_ENST00000370452_TCGA-RD-A8N9_GSK3B_chr3_119720892_-_SMAP1_chr6_71508359_length(transcript)=3094nt_BP=1265nt CGGGCTTGTGCCGCCGCCGCCGCCGCCGCCGCCCGGGCCAAGTGACAAAGGAAGGAAGGAAGCGAGGAGGAGCCGGCCCCGCAGCCGCTG ACAGGGCTCTGGGCTGGGGCAAAGCGCGGACACTTCCTGAGCGGGCACCGAGCAGAGCCGAGGGGCGGGAGGGCGGCCGAGCTGTTGCCG CGGACGGGGGAGGGGGCCCCGAGGGACGGAAGCGGTTGCCGGGTTCCCATGTCCCCGGCGAATGGGGAACAGTCGAGGAGCCGCTGCCTG GGGTCTGAAGGGAGCTGCCTCCGCCACCGCCATGGCCGCTGGATCCAGCCGCCGCCTGCAGCTGCTCCTGGCGCAATGAGGAGAGGAGCC GCCGCCACCGCCACCGCCCGCCTCTGACTGACTCGCGACTCCGCCGCCCTCTAGTTCGCCGGGCCCCTGCCGTCAGCCCGCCGGATCCCG CGGCTTGCCGGAGCTGCAGCGTTTCCCGTCGCATCTCCGAGCCACCCCCTCCCTCCCTCTCCCTCCCTCCTACCCATCCCCCTTTCTCTT CAAGCGTGAGACTCGTGATCCTTCCGCCGCTTCCCTTCTTCATTGACTCGGAAAAAAAATCCCCGAGGAAAATATAATATTCGAAGTACT CATTTTCAATCAAGTATTTGCCCCCGTTTCACGTGATACATATTTTTTTAGGATTTGCCCTCTCTTTTCTCTCCTCCCAGGAAAGGGAGG GGAAAGAATTGTATTTTTTCCCAAGTCCTAAATCATCTATATGTTAAATATCCGTGCCGATCTGTCTTGAAGGAGAAATATATCGCTTGT TTTGTTTTTTATAGTATACAAAAGGAGTGAAAAGCCAAGAGGACGAAGTCTTTTTCTTTTTCTTCTGTGGGAGAACTTAATGCTGCATTT ATCGTTAACCTAACACCCCAACATAAAGACAAAAGGAAGAAAAGGAGGAAGGAAGGAAAAGGTGATTCGCGAAGAGAGTGATCATGTCAG GGCGGCCCAGAACCACCTCCTTTGCGGAGAGCTGCAAGCCGGTGCAGCAGCCTTCAGCTTTTGGCAGCATGAAAGTTAGCAGAGACAAGG ACGGCAGCAAGGTGACAACAGTGGTGGCAACTCCTGGGCAGGGTCCAGACAGGCCACAAGAAGTCAGCTATACAGACACTAAAGTGATTG GAAATGGATCATTTGGTGTGGTATATCAAGCCAAACTTTGTGATTCAGGAGAACTGGTCGCCATCAAGAAAGTATTGCAGGACAAGAGAT TTAAGAAAGAAAAGGAAAAAAAAAAGGAAGAGAAAAAGAGAGAAAAGGAGCCAGAAAAGCCGGCAAAACCACTTACAGCTGAAAAGCTGC AGAAGAAAGATCAGCAACTGGAGCCTAAAAAAAGTACCAGCCCTAAAAAAGCTGCGGAGCCCACTGTGGATCTTTTAGGACTTGATGGCC CTGCTGTGGCACCAGTGACCAACGGGAACACAACGGTGCCACCCCTGAACGATGATCTGGACATCTTTGGACCGATGATTTCTAATCCCT TACCTGCAACTGTCATGCCCCCAGCTCAGGGGACACCCTCTGCACCAGCAGCTGCAACCCTGTCTACAGTAACATCTGGGGATCTAGATT TATTCACTGAGCAAACTACAAAATCAGAAGAAGTGGCAAAGAAACAACTTTCCAAAGACTCCATCTTATCTCTGTATGGCACAGGAACCA TTCAACAGCAAAGTACTCCTGGTGTATTTATGGGACCCACAAATATACCATTTACCTCACAAGCACCAGCTGCATTTCAGGGCTTTCCAT CGATGGGCGTGCCTGTGCCTGCAGCTCCTGGCCTTATAGGAAATGTGATGGGACAGAGTCCAAGCATGATGGTGGGCATGCCCATGCCCA ATGGGTTTATGGGAAATGCACAAACTGGTGTGATGCCACTTCCTCAGAACGTTGTTGGCCCCCAAGGAGGAATGGTGGGACAAATGGGTG CACCCCAGAGTAAGTTTGGCCTGCCGCAAGCTCAGCAGCCCCAGTGGAGCCTCTCACAGATAATGCAGAAGGGTGATGCTGTTCTCCAGC ACTCCATCAGTGCAATCTACTGGCCAATGACAAGGTGGTTAAAATGTCCTTTAGTAGATGAATCAGCAGATGGCTGGCATGAGTATCAGT AGTGCAACCCCTACTGCAGGTTTTGGCCAGCCCTCCAGCACAACAGCAGGATGGTCTGGAAGCTCATCAGGTCAGACTCTCAGCACACAA CTGTGGAAATGAAAACTGCAATACAAGTTTCATCCAGAACTACCACCTGACATTCCTTGCTGAAACGCATCTAGTTCCCCTGTTTATTCA TATGCATATTTTTTTTCTTTTTACCCATTTGTTCATATTAAGAATGATCTGATTGACCGTGTTGGTCTGTACTGATTCAATTTGATGTGG TGAAAAGCAGGTTGATAAATCATTTTATGTCAAGGGCAGCTTTGCTCATATTTCCCATGATTTCATGTACTGCATTATTTGAGAAGCTGC TCAACTTGCAAAATCAGTTTTCCTCTCAATAAAATTATAGCTCTAATGTTTGCATATAAGGGAAGTAGTTATCATGTTAGTAATACCTCT AATAGTATAAACCCCACCCCAAAATTAGCCAGTAATCCTGTAGGAAGGTACTGTATGATCAAATGTTTAATCATATAAATAGAATGTAAA TGTCTCACTGAGCACTGTTTTCTAGTGTATCAAAATGCTCTTATTTCATCATTCACTTCACTGTGCTGTTGTTATGATGTGCTTAACAGG GAACGTGATTAGTGAAAGGAAGATAAACGTGGATGTTACTCCAAAACTTCGTTTAATGAATGCTTAAAGAATTCAAATTTTATCTGCCTC TCTTGTAATTTGGATCTCTTCTTAATGTACATAGTGCTAACATGAAGACCTTTTTCTGCACTATATGCAAACAGGGTAACTAACTAAAAC AAAGCCACTTTCAATCTTCAATCCTTGAAGGTATATCTAGGTTTATGACAGTAATTGTGTTTACATTTTATGGTGCCTAGTATTGACAAA >In-frame_ENST00000264235_ENST00000370452_TCGA-RD-A8N9_GSK3B_chr3_119720892_-_SMAP1_chr6_71508359_length(amino acids)=392AA_start in transcript=983_stop in transcript=2161 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD KRFKKEKEKKKEEKKREKEPEKPAKPLTAEKLQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLNDDLDIFGPMIS NPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQQSTPGVFMGPTNIPFTSQAPAAFQG FPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWSLSQIMQKGDAV -------------------------------------------------------------- >In-frame_ENST00000264235_ENST00000370455_TCGA-RD-A8N9_GSK3B_chr3_119720892_-_SMAP1_chr6_71508359_length(transcript)=3855nt_BP=1265nt CGGGCTTGTGCCGCCGCCGCCGCCGCCGCCGCCCGGGCCAAGTGACAAAGGAAGGAAGGAAGCGAGGAGGAGCCGGCCCCGCAGCCGCTG ACAGGGCTCTGGGCTGGGGCAAAGCGCGGACACTTCCTGAGCGGGCACCGAGCAGAGCCGAGGGGCGGGAGGGCGGCCGAGCTGTTGCCG CGGACGGGGGAGGGGGCCCCGAGGGACGGAAGCGGTTGCCGGGTTCCCATGTCCCCGGCGAATGGGGAACAGTCGAGGAGCCGCTGCCTG GGGTCTGAAGGGAGCTGCCTCCGCCACCGCCATGGCCGCTGGATCCAGCCGCCGCCTGCAGCTGCTCCTGGCGCAATGAGGAGAGGAGCC GCCGCCACCGCCACCGCCCGCCTCTGACTGACTCGCGACTCCGCCGCCCTCTAGTTCGCCGGGCCCCTGCCGTCAGCCCGCCGGATCCCG CGGCTTGCCGGAGCTGCAGCGTTTCCCGTCGCATCTCCGAGCCACCCCCTCCCTCCCTCTCCCTCCCTCCTACCCATCCCCCTTTCTCTT CAAGCGTGAGACTCGTGATCCTTCCGCCGCTTCCCTTCTTCATTGACTCGGAAAAAAAATCCCCGAGGAAAATATAATATTCGAAGTACT CATTTTCAATCAAGTATTTGCCCCCGTTTCACGTGATACATATTTTTTTAGGATTTGCCCTCTCTTTTCTCTCCTCCCAGGAAAGGGAGG GGAAAGAATTGTATTTTTTCCCAAGTCCTAAATCATCTATATGTTAAATATCCGTGCCGATCTGTCTTGAAGGAGAAATATATCGCTTGT TTTGTTTTTTATAGTATACAAAAGGAGTGAAAAGCCAAGAGGACGAAGTCTTTTTCTTTTTCTTCTGTGGGAGAACTTAATGCTGCATTT ATCGTTAACCTAACACCCCAACATAAAGACAAAAGGAAGAAAAGGAGGAAGGAAGGAAAAGGTGATTCGCGAAGAGAGTGATCATGTCAG GGCGGCCCAGAACCACCTCCTTTGCGGAGAGCTGCAAGCCGGTGCAGCAGCCTTCAGCTTTTGGCAGCATGAAAGTTAGCAGAGACAAGG ACGGCAGCAAGGTGACAACAGTGGTGGCAACTCCTGGGCAGGGTCCAGACAGGCCACAAGAAGTCAGCTATACAGACACTAAAGTGATTG GAAATGGATCATTTGGTGTGGTATATCAAGCCAAACTTTGTGATTCAGGAGAACTGGTCGCCATCAAGAAAGTATTGCAGGACAAGAGAT TTAAGAAAGAAAAGGAAAAAAAAAAGGAAGAGAAAAAGAGAGAAAAGGAGCCAGAAAAGCCGGCAAAACCACTTACAGCTGAAAAGCTGC AGAAGAAAGATCAGCAACTGGAGCCTAAAAAAAGTACCAGCCCTAAAAAAGCTGCGGAGCCCACTGTGGATCTTTTAGGACTTGATGGCC CTGCTGTGGCACCAGTGACCAACGGGAACACAACGGTGCCACCCCTGAACGATGATCTGGACATCTTTGGACCGATGATTTCTAATCCCT TACCTGCAACTGTCATGCCCCCAGCTCAGGGGACACCCTCTGCACCAGCAGCTGCAACCCTGTCTACAGTAACATCTGGGGATCTAGATT TATTCACTGAGCAAACTACAAAATCAGAAGAAGTGGCAAAGAAACAACTTTCCAAAGACTCCATCTTATCTCTGTATGGCACAGGAACCA TTCAACAGCAAAGTACTCCTGGTGTATTTATGGGACCCACAAATATACCATTTACCTCACAAGCACCAGCTGCATTTCAGGGCTTTCCAT CGATGGGCGTGCCTGTGCCTGCAGCTCCTGGCCTTATAGGAAATGTGATGGGACAGAGTCCAAGCATGATGGTGGGCATGCCCATGCCCA ATGGGTTTATGGGAAATGCACAAACTGGTGTGATGCCACTTCCTCAGAACGTTGTTGGCCCCCAAGGAGGAATGGTGGGACAAATGGGTG CACCCCAGAGTAAGTTTGGCCTGCCGCAAGCTCAGCAGCCCCAGTGGAGCCTCTCACAGATGAATCAGCAGATGGCTGGCATGAGTATCA GTAGTGCAACCCCTACTGCAGGTTTTGGCCAGCCCTCCAGCACAACAGCAGGATGGTCTGGAAGCTCATCAGGTCAGACTCTCAGCACAC AACTGTGGAAATGAAAACTGCAATACAAGTTTCATCCAGAACTACCACCTGACATTCCTTGCTGAAACGCATCTAGTTCCCCTGTTTATT CATATGCATATTTTTTTTCTTTTTACCCATTTGTTCATATTAAGAATGATCTGATTGACCGTGTTGGTCTGTACTGATTCAATTTGATGT GGTGAAAAGCAGGTTGATAAATCATTTTATGTCAAGGGCAGCTTTGCTCATATTTCCCATGATTTCATGTACTGCATTATTTGAGAAGCT GCTCAACTTGCAAAATCAGTTTTCCTCTCAATAAAATTATAGCTCTAATGTTTGCATATAAGGGAAGTAGTTATCATGTTAGTAATACCT CTAATAGTATAAACCCCACCCCAAAATTAGCCAGTAATCCTGTAGGAAGGTACTGTATGATCAAATGTTTAATCATATAAATAGAATGTA AATGTCTCACTGAGCACTGTTTTCTAGTGTATCAAAATGCTCTTATTTCATCATTCACTTCACTGTGCTGTTGTTATGATGTGCTTAACA GGGAACGTGATTAGTGAAAGGAAGATAAACGTGGATGTTACTCCAAAACTTCGTTTAATGAATGCTTAAAGAATTCAAATTTTATCTGCC TCTCTTGTAATTTGGATCTCTTCTTAATGTACATAGTGCTAACATGAAGACCTTTTTCTGCACTATATGCAAACAGGGTAACTAACTAAA ACAAAGCCACTTTCAATCTTCAATCCTTGAAGGTATATCTAGGTTTATGACAGTAATTGTGTTTACATTTTATGGTGCCTAGTATTGACA AAATGTTATTTCCCTACATTAAACATGACTCCATAGACCTTTTCATTTGTGGGTTTTTATTTCCTATGATGTATACTGCCACTAACCTTC CAAAAATTACTTAGTATTGCAAAGTCAGGAATCATCAGGAACGTTTAGCTGACAAAATACTTGTCTGTTTTAAAAACCTGTTCAAGTCTA CCAACCTGTTCAAGTCTACCAATTATAAGGGCAAATTGGAGAAAAAGAAAAAATATATACTCAAGAGTGGTATCTTGCAGTATCGGCACT GTACAAAAAAATCTTCCAATTTAGTTGTTGTAGAGAAAACATGCAGAACAAATGAAGACAAAACATACATTTTGTACCAACCATCCAATT AGCTTATGTTAACTGACAAGCTCCATTTAAACAGATGTCCATCAGATGACAAGAAAGGCTGCTGTACTGAAGTAAAACAAACAATACCTG AATGCTCTGTAGCCTAAACTCCAAACATCCTCTTCCATATGGATCCACTGGCTGGACAAACTGCACCAGTTGCTGCTTCAATTTATACCT CAATTTTCACTGTGTCCAGGTGGTACTTTGGCTCGTTGGCTAGATTAACCTTCTCTGTCCGAGTGTGCCACACGAGAACCTGAAGGGGAA GGAAATAGCTTGGGTAGCGCACTCTTCATGGTGACACTCGAGGTCGGGCAGCACAAGTGTAATGAATACCTTAGTGCAGTTATTTGCTTT CGGTTCCAGTTCTTCGACTGTTGTTATCTGTTTGAGAAAGTCAGATTCTTGCATCCCTGGCTGGGATCCACGACGCTTAAATACAGCTTT >In-frame_ENST00000264235_ENST00000370455_TCGA-RD-A8N9_GSK3B_chr3_119720892_-_SMAP1_chr6_71508359_length(amino acids)=396AA_start in transcript=983_stop in transcript=2173 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD KRFKKEKEKKKEEKKREKEPEKPAKPLTAEKLQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLNDDLDIFGPMIS NPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQQSTPGVFMGPTNIPFTSQAPAAFQG FPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWSLSQMNQQMAGM -------------------------------------------------------------- >In-frame_ENST00000316626_ENST00000316999_TCGA-RD-A8N9_GSK3B_chr3_119720892_-_SMAP1_chr6_71508359_length(transcript)=2255nt_BP=514nt ATCATCTATATGTTAAATATCCGTGCCGATCTGTCTTGAAGGAGAAATATATCGCTTGTTTTGTTTTTTATAGTATACAAAAGGAGTGAA AAGCCAAGAGGACGAAGTCTTTTTCTTTTTCTTCTGTGGGAGAACTTAATGCTGCATTTATCGTTAACCTAACACCCCAACATAAAGACA AAAGGAAGAAAAGGAGGAAGGAAGGAAAAGGTGATTCGCGAAGAGAGTGATCATGTCAGGGCGGCCCAGAACCACCTCCTTTGCGGAGAG CTGCAAGCCGGTGCAGCAGCCTTCAGCTTTTGGCAGCATGAAAGTTAGCAGAGACAAGGACGGCAGCAAGGTGACAACAGTGGTGGCAAC TCCTGGGCAGGGTCCAGACAGGCCACAAGAAGTCAGCTATACAGACACTAAAGTGATTGGAAATGGATCATTTGGTGTGGTATATCAAGC CAAACTTTGTGATTCAGGAGAACTGGTCGCCATCAAGAAAGTATTGCAGGACAAGAGATTTAAGAAAGAAAAGGAAAAAAAAAAGGAAGA GAAAAAGAGAGAAAAGGAGCCAGAAAAGCCGGCAAAACCACTTACAGCTGAAAAGCTGCAGAAGAAAGATCAGCAACTGGAGCCTAAAAA AAGTACCAGCCCTAAAAAAGCTGCGGAGCCCACTGTGGATCTTTTAGGACTTGATGGCCCTGCTGTGGCACCAGTGACCAACGGGAACAC AACGGTGCCACCCCTGAACGATGATCTGGACATCTTTGGACCGATGATTTCTAATCCCTTACCTGCAACTGTCATGCCCCCAGCTCAGGG GACACCCTCTGCACCAGCAGCTGCAACCCTGTCTACAGTAACATCTGGGGATCTAGATTTATTCACTGAGCAAACTACAAAATCAGAAGA AGTGGCAAAGAAACAACTTTCCAAAGACTCCATCTTATCTCTGTATGGCACAGGAACCATTCAACAGCAAAGTACTCCTGGTGTATTTAT GGGACCCACAAATATACCATTTACCTCACAAGCACCAGCTGCATTTCAGGGCTTTCCATCGATGGGCGTGCCTGTGCCTGCAGCTCCTGG CCTTATAGGAAATGTGATGGGACAGAGTCCAAGCATGATGGTGGGCATGCCCATGCCCAATGGGTTTATGGGAAATGCACAAACTGGTGT GATGCCACTTCCTCAGAACGTTGTTGGCCCCCAAGGAGGAATGGTGGGACAAATGGGTGCACCCCAGAGTAAGTTTGGCCTGCCGCAAGC TCAGCAGCCCCAGTGGAGCCTCTCACAGATGAATCAGCAGATGGCTGGCATGAGTATCAGTAGTGCAACCCCTACTGCAGGTTTTGGCCA GCCCTCCAGCACAACAGCAGGATGGTCTGGAAGCTCATCAGGTCAGACTCTCAGCACACAACTGTGGAAATGAAAACTGCAATACAAGTT TCATCCAGAACTACCACCTGACATTCCTTGCTGAAACGCATCTAGTTCCCCTGTTTATTCATATGCATATTTTTTTTCTTTTTACCCATT TGTTCATATTAAGAATGATCTGATTGACCGTGTTGGTCTGTACTGATTCAATTTGATGTGGTGAAAAGCAGGTTGATAAATCATTTTATG TCAAGGGCAGCTTTGCTCATATTTCCCATGATTTCATGTACTGCATTATTTGAGAAGCTGCTCAACTTGCAAAATCAGTTTTCCTCTCAA TAAAATTATAGCTCTAATGTTTGCATATAAGGGAAGTAGTTATCATGTTAGTAATACCTCTAATAGTATAAACCCCACCCCAAAATTAGC CAGTAATCCTGTAGGAAGGTACTGTATGATCAAATGTTTAATCATATAAATAGAATGTAAATGTCTCACTGAGCACTGTTTTCTAGTGTA TCAAAATGCTCTTATTTCATCATTCACTTCACTGTGCTGTTGTTATGATGTGCTTAACAGGGAACGTGATTAGTGAAAGGAAGATAAACG TGGATGTTACTCCAAAACTTCGTTTAATGAATGCTTAAAGAATTCAAATTTTATCTGCCTCTCTTGTAATTTGGATCTCTTCTTAATGTA CATAGTGCTAACATGAAGACCTTTTTCTGCACTATATGCAAACAGGGTAACTAACTAAAACAAAGCCACTTTCAATCTTCAATCCTTGAA GGTATATCTAGGTTTATGACAGTAATTGTGTTTACATTTTATGGTGCCTAGTATTGACAAAATGTTATTTCCCTACATTAAACATGACTC >In-frame_ENST00000316626_ENST00000316999_TCGA-RD-A8N9_GSK3B_chr3_119720892_-_SMAP1_chr6_71508359_length(amino acids)=396AA_start in transcript=232_stop in transcript=1422 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD KRFKKEKEKKKEEKKREKEPEKPAKPLTAEKLQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLNDDLDIFGPMIS NPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQQSTPGVFMGPTNIPFTSQAPAAFQG FPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWSLSQMNQQMAGM -------------------------------------------------------------- >In-frame_ENST00000316626_ENST00000370452_TCGA-RD-A8N9_GSK3B_chr3_119720892_-_SMAP1_chr6_71508359_length(transcript)=2343nt_BP=514nt ATCATCTATATGTTAAATATCCGTGCCGATCTGTCTTGAAGGAGAAATATATCGCTTGTTTTGTTTTTTATAGTATACAAAAGGAGTGAA AAGCCAAGAGGACGAAGTCTTTTTCTTTTTCTTCTGTGGGAGAACTTAATGCTGCATTTATCGTTAACCTAACACCCCAACATAAAGACA AAAGGAAGAAAAGGAGGAAGGAAGGAAAAGGTGATTCGCGAAGAGAGTGATCATGTCAGGGCGGCCCAGAACCACCTCCTTTGCGGAGAG CTGCAAGCCGGTGCAGCAGCCTTCAGCTTTTGGCAGCATGAAAGTTAGCAGAGACAAGGACGGCAGCAAGGTGACAACAGTGGTGGCAAC TCCTGGGCAGGGTCCAGACAGGCCACAAGAAGTCAGCTATACAGACACTAAAGTGATTGGAAATGGATCATTTGGTGTGGTATATCAAGC CAAACTTTGTGATTCAGGAGAACTGGTCGCCATCAAGAAAGTATTGCAGGACAAGAGATTTAAGAAAGAAAAGGAAAAAAAAAAGGAAGA GAAAAAGAGAGAAAAGGAGCCAGAAAAGCCGGCAAAACCACTTACAGCTGAAAAGCTGCAGAAGAAAGATCAGCAACTGGAGCCTAAAAA AAGTACCAGCCCTAAAAAAGCTGCGGAGCCCACTGTGGATCTTTTAGGACTTGATGGCCCTGCTGTGGCACCAGTGACCAACGGGAACAC AACGGTGCCACCCCTGAACGATGATCTGGACATCTTTGGACCGATGATTTCTAATCCCTTACCTGCAACTGTCATGCCCCCAGCTCAGGG GACACCCTCTGCACCAGCAGCTGCAACCCTGTCTACAGTAACATCTGGGGATCTAGATTTATTCACTGAGCAAACTACAAAATCAGAAGA AGTGGCAAAGAAACAACTTTCCAAAGACTCCATCTTATCTCTGTATGGCACAGGAACCATTCAACAGCAAAGTACTCCTGGTGTATTTAT GGGACCCACAAATATACCATTTACCTCACAAGCACCAGCTGCATTTCAGGGCTTTCCATCGATGGGCGTGCCTGTGCCTGCAGCTCCTGG CCTTATAGGAAATGTGATGGGACAGAGTCCAAGCATGATGGTGGGCATGCCCATGCCCAATGGGTTTATGGGAAATGCACAAACTGGTGT GATGCCACTTCCTCAGAACGTTGTTGGCCCCCAAGGAGGAATGGTGGGACAAATGGGTGCACCCCAGAGTAAGTTTGGCCTGCCGCAAGC TCAGCAGCCCCAGTGGAGCCTCTCACAGATAATGCAGAAGGGTGATGCTGTTCTCCAGCACTCCATCAGTGCAATCTACTGGCCAATGAC AAGGTGGTTAAAATGTCCTTTAGTAGATGAATCAGCAGATGGCTGGCATGAGTATCAGTAGTGCAACCCCTACTGCAGGTTTTGGCCAGC CCTCCAGCACAACAGCAGGATGGTCTGGAAGCTCATCAGGTCAGACTCTCAGCACACAACTGTGGAAATGAAAACTGCAATACAAGTTTC ATCCAGAACTACCACCTGACATTCCTTGCTGAAACGCATCTAGTTCCCCTGTTTATTCATATGCATATTTTTTTTCTTTTTACCCATTTG TTCATATTAAGAATGATCTGATTGACCGTGTTGGTCTGTACTGATTCAATTTGATGTGGTGAAAAGCAGGTTGATAAATCATTTTATGTC AAGGGCAGCTTTGCTCATATTTCCCATGATTTCATGTACTGCATTATTTGAGAAGCTGCTCAACTTGCAAAATCAGTTTTCCTCTCAATA AAATTATAGCTCTAATGTTTGCATATAAGGGAAGTAGTTATCATGTTAGTAATACCTCTAATAGTATAAACCCCACCCCAAAATTAGCCA GTAATCCTGTAGGAAGGTACTGTATGATCAAATGTTTAATCATATAAATAGAATGTAAATGTCTCACTGAGCACTGTTTTCTAGTGTATC AAAATGCTCTTATTTCATCATTCACTTCACTGTGCTGTTGTTATGATGTGCTTAACAGGGAACGTGATTAGTGAAAGGAAGATAAACGTG GATGTTACTCCAAAACTTCGTTTAATGAATGCTTAAAGAATTCAAATTTTATCTGCCTCTCTTGTAATTTGGATCTCTTCTTAATGTACA TAGTGCTAACATGAAGACCTTTTTCTGCACTATATGCAAACAGGGTAACTAACTAAAACAAAGCCACTTTCAATCTTCAATCCTTGAAGG TATATCTAGGTTTATGACAGTAATTGTGTTTACATTTTATGGTGCCTAGTATTGACAAAATGTTATTTCCCTACATTAAACATGACTCCA >In-frame_ENST00000316626_ENST00000370452_TCGA-RD-A8N9_GSK3B_chr3_119720892_-_SMAP1_chr6_71508359_length(amino acids)=392AA_start in transcript=232_stop in transcript=1410 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD KRFKKEKEKKKEEKKREKEPEKPAKPLTAEKLQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLNDDLDIFGPMIS NPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQQSTPGVFMGPTNIPFTSQAPAAFQG FPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWSLSQIMQKGDAV -------------------------------------------------------------- >In-frame_ENST00000316626_ENST00000370455_TCGA-RD-A8N9_GSK3B_chr3_119720892_-_SMAP1_chr6_71508359_length(transcript)=3104nt_BP=514nt ATCATCTATATGTTAAATATCCGTGCCGATCTGTCTTGAAGGAGAAATATATCGCTTGTTTTGTTTTTTATAGTATACAAAAGGAGTGAA AAGCCAAGAGGACGAAGTCTTTTTCTTTTTCTTCTGTGGGAGAACTTAATGCTGCATTTATCGTTAACCTAACACCCCAACATAAAGACA AAAGGAAGAAAAGGAGGAAGGAAGGAAAAGGTGATTCGCGAAGAGAGTGATCATGTCAGGGCGGCCCAGAACCACCTCCTTTGCGGAGAG CTGCAAGCCGGTGCAGCAGCCTTCAGCTTTTGGCAGCATGAAAGTTAGCAGAGACAAGGACGGCAGCAAGGTGACAACAGTGGTGGCAAC TCCTGGGCAGGGTCCAGACAGGCCACAAGAAGTCAGCTATACAGACACTAAAGTGATTGGAAATGGATCATTTGGTGTGGTATATCAAGC CAAACTTTGTGATTCAGGAGAACTGGTCGCCATCAAGAAAGTATTGCAGGACAAGAGATTTAAGAAAGAAAAGGAAAAAAAAAAGGAAGA GAAAAAGAGAGAAAAGGAGCCAGAAAAGCCGGCAAAACCACTTACAGCTGAAAAGCTGCAGAAGAAAGATCAGCAACTGGAGCCTAAAAA AAGTACCAGCCCTAAAAAAGCTGCGGAGCCCACTGTGGATCTTTTAGGACTTGATGGCCCTGCTGTGGCACCAGTGACCAACGGGAACAC AACGGTGCCACCCCTGAACGATGATCTGGACATCTTTGGACCGATGATTTCTAATCCCTTACCTGCAACTGTCATGCCCCCAGCTCAGGG GACACCCTCTGCACCAGCAGCTGCAACCCTGTCTACAGTAACATCTGGGGATCTAGATTTATTCACTGAGCAAACTACAAAATCAGAAGA AGTGGCAAAGAAACAACTTTCCAAAGACTCCATCTTATCTCTGTATGGCACAGGAACCATTCAACAGCAAAGTACTCCTGGTGTATTTAT GGGACCCACAAATATACCATTTACCTCACAAGCACCAGCTGCATTTCAGGGCTTTCCATCGATGGGCGTGCCTGTGCCTGCAGCTCCTGG CCTTATAGGAAATGTGATGGGACAGAGTCCAAGCATGATGGTGGGCATGCCCATGCCCAATGGGTTTATGGGAAATGCACAAACTGGTGT GATGCCACTTCCTCAGAACGTTGTTGGCCCCCAAGGAGGAATGGTGGGACAAATGGGTGCACCCCAGAGTAAGTTTGGCCTGCCGCAAGC TCAGCAGCCCCAGTGGAGCCTCTCACAGATGAATCAGCAGATGGCTGGCATGAGTATCAGTAGTGCAACCCCTACTGCAGGTTTTGGCCA GCCCTCCAGCACAACAGCAGGATGGTCTGGAAGCTCATCAGGTCAGACTCTCAGCACACAACTGTGGAAATGAAAACTGCAATACAAGTT TCATCCAGAACTACCACCTGACATTCCTTGCTGAAACGCATCTAGTTCCCCTGTTTATTCATATGCATATTTTTTTTCTTTTTACCCATT TGTTCATATTAAGAATGATCTGATTGACCGTGTTGGTCTGTACTGATTCAATTTGATGTGGTGAAAAGCAGGTTGATAAATCATTTTATG TCAAGGGCAGCTTTGCTCATATTTCCCATGATTTCATGTACTGCATTATTTGAGAAGCTGCTCAACTTGCAAAATCAGTTTTCCTCTCAA TAAAATTATAGCTCTAATGTTTGCATATAAGGGAAGTAGTTATCATGTTAGTAATACCTCTAATAGTATAAACCCCACCCCAAAATTAGC CAGTAATCCTGTAGGAAGGTACTGTATGATCAAATGTTTAATCATATAAATAGAATGTAAATGTCTCACTGAGCACTGTTTTCTAGTGTA TCAAAATGCTCTTATTTCATCATTCACTTCACTGTGCTGTTGTTATGATGTGCTTAACAGGGAACGTGATTAGTGAAAGGAAGATAAACG TGGATGTTACTCCAAAACTTCGTTTAATGAATGCTTAAAGAATTCAAATTTTATCTGCCTCTCTTGTAATTTGGATCTCTTCTTAATGTA CATAGTGCTAACATGAAGACCTTTTTCTGCACTATATGCAAACAGGGTAACTAACTAAAACAAAGCCACTTTCAATCTTCAATCCTTGAA GGTATATCTAGGTTTATGACAGTAATTGTGTTTACATTTTATGGTGCCTAGTATTGACAAAATGTTATTTCCCTACATTAAACATGACTC CATAGACCTTTTCATTTGTGGGTTTTTATTTCCTATGATGTATACTGCCACTAACCTTCCAAAAATTACTTAGTATTGCAAAGTCAGGAA TCATCAGGAACGTTTAGCTGACAAAATACTTGTCTGTTTTAAAAACCTGTTCAAGTCTACCAACCTGTTCAAGTCTACCAATTATAAGGG CAAATTGGAGAAAAAGAAAAAATATATACTCAAGAGTGGTATCTTGCAGTATCGGCACTGTACAAAAAAATCTTCCAATTTAGTTGTTGT AGAGAAAACATGCAGAACAAATGAAGACAAAACATACATTTTGTACCAACCATCCAATTAGCTTATGTTAACTGACAAGCTCCATTTAAA CAGATGTCCATCAGATGACAAGAAAGGCTGCTGTACTGAAGTAAAACAAACAATACCTGAATGCTCTGTAGCCTAAACTCCAAACATCCT CTTCCATATGGATCCACTGGCTGGACAAACTGCACCAGTTGCTGCTTCAATTTATACCTCAATTTTCACTGTGTCCAGGTGGTACTTTGG CTCGTTGGCTAGATTAACCTTCTCTGTCCGAGTGTGCCACACGAGAACCTGAAGGGGAAGGAAATAGCTTGGGTAGCGCACTCTTCATGG TGACACTCGAGGTCGGGCAGCACAAGTGTAATGAATACCTTAGTGCAGTTATTTGCTTTCGGTTCCAGTTCTTCGACTGTTGTTATCTGT TTGAGAAAGTCAGATTCTTGCATCCCTGGCTGGGATCCACGACGCTTAAATACAGCTTTTGGATTGGACAAAATGACTTGAAGACTTACA >In-frame_ENST00000316626_ENST00000370455_TCGA-RD-A8N9_GSK3B_chr3_119720892_-_SMAP1_chr6_71508359_length(amino acids)=396AA_start in transcript=232_stop in transcript=1422 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD KRFKKEKEKKKEEKKREKEPEKPAKPLTAEKLQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLNDDLDIFGPMIS NPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQQSTPGVFMGPTNIPFTSQAPAAFQG FPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWSLSQMNQQMAGM -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for GSK3B-SMAP1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for GSK3B-SMAP1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for GSK3B-SMAP1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GSK3B | C0005586 | Bipolar Disorder | 6 | CTD_human;PSYGENET |
Hgene | GSK3B | C0011581 | Depressive disorder | 5 | CTD_human;PSYGENET |
Hgene | GSK3B | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
Hgene | GSK3B | C0011570 | Mental Depression | 3 | PSYGENET |
Hgene | GSK3B | C0002395 | Alzheimer's Disease | 2 | CTD_human |
Hgene | GSK3B | C0011265 | Presenile dementia | 2 | CTD_human |
Hgene | GSK3B | C0011573 | Endogenous depression | 2 | CTD_human |
Hgene | GSK3B | C0025193 | Melancholia | 2 | CTD_human |
Hgene | GSK3B | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
Hgene | GSK3B | C0036341 | Schizophrenia | 2 | CTD_human |
Hgene | GSK3B | C0041696 | Unipolar Depression | 2 | CTD_human |
Hgene | GSK3B | C0086133 | Depressive Syndrome | 2 | CTD_human |
Hgene | GSK3B | C0276496 | Familial Alzheimer Disease (FAD) | 2 | CTD_human |
Hgene | GSK3B | C0282126 | Depression, Neurotic | 2 | CTD_human |
Hgene | GSK3B | C0376358 | Malignant neoplasm of prostate | 2 | CTD_human |
Hgene | GSK3B | C0494463 | Alzheimer Disease, Late Onset | 2 | CTD_human |
Hgene | GSK3B | C0525045 | Mood Disorders | 2 | PSYGENET |
Hgene | GSK3B | C0546126 | Acute Confusional Senile Dementia | 2 | CTD_human |
Hgene | GSK3B | C0750900 | Alzheimer's Disease, Focal Onset | 2 | CTD_human |
Hgene | GSK3B | C0750901 | Alzheimer Disease, Early Onset | 2 | CTD_human |
Hgene | GSK3B | C0000772 | Multiple congenital anomalies | 1 | CTD_human |
Hgene | GSK3B | C0003865 | Arthritis, Adjuvant-Induced | 1 | CTD_human |
Hgene | GSK3B | C0005587 | Depression, Bipolar | 1 | CTD_human |
Hgene | GSK3B | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | GSK3B | C0009241 | Cognition Disorders | 1 | CTD_human |
Hgene | GSK3B | C0018800 | Cardiomegaly | 1 | CTD_human |
Hgene | GSK3B | C0018801 | Heart failure | 1 | CTD_human |
Hgene | GSK3B | C0018802 | Congestive heart failure | 1 | CTD_human |
Hgene | GSK3B | C0020538 | Hypertensive disease | 1 | CTD_human |
Hgene | GSK3B | C0022660 | Kidney Failure, Acute | 1 | CTD_human |
Hgene | GSK3B | C0023212 | Left-Sided Heart Failure | 1 | CTD_human |
Hgene | GSK3B | C0024713 | Manic Disorder | 1 | CTD_human |
Hgene | GSK3B | C0026846 | Muscular Atrophy | 1 | CTD_human |
Hgene | GSK3B | C0027051 | Myocardial Infarction | 1 | CTD_human |
Hgene | GSK3B | C0031154 | Peritonitis | 1 | CTD_human |
Hgene | GSK3B | C0235527 | Heart Failure, Right-Sided | 1 | CTD_human |
Hgene | GSK3B | C0270948 | Neurogenic Muscular Atrophy | 1 | CTD_human |
Hgene | GSK3B | C0334634 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 1 | CTD_human |
Hgene | GSK3B | C0338831 | Manic | 1 | CTD_human |
Hgene | GSK3B | C0751958 | Lymphoma, Lymphocytic, Intermediate | 1 | CTD_human |
Hgene | GSK3B | C0949664 | Tauopathies | 1 | CTD_human |
Hgene | GSK3B | C0971858 | Arthritis, Collagen-Induced | 1 | CTD_human |
Hgene | GSK3B | C0993582 | Arthritis, Experimental | 1 | CTD_human |
Hgene | GSK3B | C1383860 | Cardiac Hypertrophy | 1 | CTD_human |
Hgene | GSK3B | C1449646 | Primary Peritonitis | 1 | CTD_human |
Hgene | GSK3B | C1449647 | Secondary Peritonitis | 1 | CTD_human |
Hgene | GSK3B | C1565662 | Acute Kidney Insufficiency | 1 | CTD_human |
Hgene | GSK3B | C1866282 | CEROID LIPOFUSCINOSIS, NEURONAL, 6 | 1 | CTD_human |
Hgene | GSK3B | C1959583 | Myocardial Failure | 1 | CTD_human |
Hgene | GSK3B | C1961112 | Heart Decompensation | 1 | CTD_human |
Hgene | GSK3B | C2609414 | Acute kidney injury | 1 | CTD_human |