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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GSTM1-PAM (FusionGDB2 ID:34986)

Fusion Gene Summary for GSTM1-PAM

check button Fusion gene summary
Fusion gene informationFusion gene name: GSTM1-PAM
Fusion gene ID: 34986
HgeneTgene
Gene symbol

GSTM1

PAM

Gene ID

2944

23077

Gene nameglutathione S-transferase mu 1MYC binding protein 2
SynonymsGST1|GSTM1-1|GSTM1a-1a|GSTM1b-1b|GTH4|GTM1|H-B|MU|MU-1Myc-bp2|PAM|PHR1|Phr
Cytomap

1p13.3

13q22.3

Type of geneprotein-codingprotein-coding
Descriptionglutathione S-transferase Mu 1GST HB subunit 4GST class-mu 1HB subunit 4S-(hydroxyalkyl)glutathione lyaseglutathione S-alkyltransferaseglutathione S-aralkyltransferaseglutathione S-aryltransferaseglutathione S-transferase M1E3 ubiquitin-protein ligase MYCBP2HighwireMYC binding protein 2, E3 ubiquitin protein ligasePAM/Highwire/RPM-1 protein 1RING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with Myc
Modification date2020032220200313
UniProtAcc

P09488

.
Ensembl transtripts involved in fusion geneENST00000490021, ENST00000309851, 
ENST00000369823, ENST00000349334, 
ENST00000483399, ENST00000369819, 
ENST00000438793, ENST00000346918, 
ENST00000379787, ENST00000348126, 
ENST00000304400, ENST00000274392, 
ENST00000455264, ENST00000513648, 
Fusion gene scores* DoF score1 X 1 X 1=110 X 12 X 3=360
# samples 110
** MAII scorelog2(1/1*10)=3.32192809488736log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GSTM1 [Title/Abstract] AND PAM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGSTM1(110232186)-PAM(102363887), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGSTM1

GO:0006749

glutathione metabolic process

8373352

HgeneGSTM1

GO:0018916

nitrobenzene metabolic process

8373352

HgeneGSTM1

GO:0042178

xenobiotic catabolic process

8373352

HgeneGSTM1

GO:0070458

cellular detoxification of nitrogen compound

8373352

TgenePAM

GO:0016567

protein ubiquitination

29643511

TgenePAM

GO:0031398

positive regulation of protein ubiquitination

20534529


check buttonFusion gene breakpoints across GSTM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PAM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADT220445GSTM1chr1

110232186

-PAMchr5

102363887

+


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Fusion Gene ORF analysis for GSTM1-PAM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000490021ENST00000438793GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000490021ENST00000346918GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000490021ENST00000379787GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000490021ENST00000348126GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000490021ENST00000304400GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000490021ENST00000274392GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000490021ENST00000455264GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000490021ENST00000513648GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-3CDSENST00000309851ENST00000438793GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000309851ENST00000346918GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000309851ENST00000379787GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000309851ENST00000348126GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000309851ENST00000304400GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000309851ENST00000274392GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000309851ENST00000455264GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000309851ENST00000513648GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-3CDSENST00000369823ENST00000438793GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000369823ENST00000346918GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000369823ENST00000379787GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000369823ENST00000348126GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000369823ENST00000304400GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000369823ENST00000274392GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000369823ENST00000455264GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000369823ENST00000513648GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-3CDSENST00000349334ENST00000438793GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000349334ENST00000346918GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000349334ENST00000379787GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000349334ENST00000348126GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000349334ENST00000304400GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000349334ENST00000274392GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000349334ENST00000455264GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000349334ENST00000513648GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-3CDSENST00000483399ENST00000438793GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000483399ENST00000346918GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000483399ENST00000379787GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000483399ENST00000348126GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000483399ENST00000304400GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000483399ENST00000274392GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000483399ENST00000455264GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000483399ENST00000513648GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-3CDSENST00000369819ENST00000438793GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000369819ENST00000346918GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000369819ENST00000379787GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000369819ENST00000348126GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000369819ENST00000304400GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000369819ENST00000274392GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000369819ENST00000455264GSTM1chr1

110232186

-PAMchr5

102363887

+
intron-intronENST00000369819ENST00000513648GSTM1chr1

110232186

-PAMchr5

102363887

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GSTM1-PAM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GSTM1-PAM


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSTM1

P09488

.
FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). {ECO:0000269|PubMed:16548513, ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:9084911}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GSTM1-PAM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GSTM1-PAM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GSTM1-PAM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGSTM1P09488DB00143GlutathioneSmall moleculeApproved|Investigational|Nutraceutical
HgeneGSTM1P09488DB00143GlutathioneSmall moleculeApproved|Investigational|Nutraceutical
HgeneGSTM1P09488DB00608ChloroquineInhibitorSmall moleculeApproved|Investigational|Vet_approved
HgeneGSTM1P09488DB00608ChloroquineInhibitorSmall moleculeApproved|Investigational|Vet_approved

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Related Diseases for GSTM1-PAM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGSTM1C0011570Mental Depression4PSYGENET
HgeneGSTM1C0011581Depressive disorder4PSYGENET
HgeneGSTM1C0036341Schizophrenia4PSYGENET
HgeneGSTM1C0024121Lung Neoplasms3CTD_human
HgeneGSTM1C0033578Prostatic Neoplasms3CTD_human
HgeneGSTM1C0242379Malignant neoplasm of lung3CTD_human
HgeneGSTM1C0376358Malignant neoplasm of prostate3CTD_human
HgeneGSTM1C0004096Asthma2CTD_human
HgeneGSTM1C0004403Autosome Abnormalities2CTD_human
HgeneGSTM1C0005586Bipolar Disorder2PSYGENET
HgeneGSTM1C0005684Malignant neoplasm of urinary bladder2CTD_human
HgeneGSTM1C0005695Bladder Neoplasm2CTD_human
HgeneGSTM1C0007134Renal Cell Carcinoma2CTD_human
HgeneGSTM1C0008625Chromosome Aberrations2CTD_human
HgeneGSTM1C0019193Hepatitis, Toxic2CTD_human
HgeneGSTM1C0023418leukemia2CTD_human
HgeneGSTM1C0279702Conventional (Clear Cell) Renal Cell Carcinoma2CTD_human
HgeneGSTM1C0860207Drug-Induced Liver Disease2CTD_human
HgeneGSTM1C1262760Hepatitis, Drug-Induced2CTD_human
HgeneGSTM1C1266042Chromophobe Renal Cell Carcinoma2CTD_human
HgeneGSTM1C1266043Sarcomatoid Renal Cell Carcinoma2CTD_human
HgeneGSTM1C1266044Collecting Duct Carcinoma of the Kidney2CTD_human
HgeneGSTM1C1306837Papillary Renal Cell Carcinoma2CTD_human
HgeneGSTM1C3658290Drug-Induced Acute Liver Injury2CTD_human
HgeneGSTM1C4277682Chemical and Drug Induced Liver Injury2CTD_human
HgeneGSTM1C4279912Chemically-Induced Liver Toxicity2CTD_human
HgeneGSTM1C0004153Atherosclerosis1CTD_human
HgeneGSTM1C0004352Autistic Disorder1CTD_human
HgeneGSTM1C0007137Squamous cell carcinoma1CTD_human
HgeneGSTM1C0009402Colorectal Carcinoma1CTD_human
HgeneGSTM1C0009404Colorectal Neoplasms1CTD_human
HgeneGSTM1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneGSTM1C0013182Drug Allergy1CTD_human
HgeneGSTM1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneGSTM1C0023903Liver neoplasms1CTD_human
HgeneGSTM1C0025500Mesothelioma1CTD_human
HgeneGSTM1C0030567Parkinson Disease1CTD_human
HgeneGSTM1C0034734Raynaud Disease1CTD_human
HgeneGSTM1C0034735Raynaud Phenomenon1CTD_human
HgeneGSTM1C0037274Dermatologic disorders1CTD_human
HgeneGSTM1C0042109Urticaria1CTD_human
HgeneGSTM1C0085183Neoplasms, Second Primary1CTD_human
HgeneGSTM1C0086696Neoplasms, Therapy-Associated1CTD_human
HgeneGSTM1C0236733Amphetamine-Related Disorders1CTD_human
HgeneGSTM1C0236804Amphetamine Addiction1CTD_human
HgeneGSTM1C0236807Amphetamine Abuse1CTD_human
HgeneGSTM1C0263454Chloracne1CTD_human
HgeneGSTM1C0270715Degenerative Diseases, Central Nervous System1CTD_human
HgeneGSTM1C0333704Chromosome Breaks1CTD_human
HgeneGSTM1C0345904Malignant neoplasm of liver1CTD_human
HgeneGSTM1C0345967Malignant mesothelioma1CTD_human
HgeneGSTM1C0376628Chromosome Breakage1CTD_human
HgeneGSTM1C0400966Non-alcoholic Fatty Liver Disease1CTD_human
HgeneGSTM1C0524851Neurodegenerative Disorders1CTD_human
HgeneGSTM1C0751733Degenerative Diseases, Spinal Cord1CTD_human
HgeneGSTM1C0877578Treatment related secondary malignancy1CTD_human
HgeneGSTM1C1449861Micronuclei, Chromosome-Defective1CTD_human
HgeneGSTM1C1449862Micronuclei, Genotoxicant-Induced1CTD_human
HgeneGSTM1C1563937Atherogenesis1CTD_human
HgeneGSTM1C2239176Liver carcinoma1CTD_human
HgeneGSTM1C3241937Nonalcoholic Steatohepatitis1CTD_human
TgenePAMC0011860Diabetes Mellitus, Non-Insulin-Dependent2CTD_human
TgenePAMC0003469Anxiety Disorders1CTD_human
TgenePAMC0022333Jacksonian Seizure1CTD_human
TgenePAMC0036572Seizures1CTD_human
TgenePAMC0149958Complex partial seizures1CTD_human
TgenePAMC0234533Generalized seizures1CTD_human
TgenePAMC0234535Clonic Seizures1CTD_human
TgenePAMC0270824Visual seizure1CTD_human
TgenePAMC0270844Tonic Seizures1CTD_human
TgenePAMC0270846Epileptic drop attack1CTD_human
TgenePAMC0376280Anxiety States, Neurotic1CTD_human
TgenePAMC0422850Seizures, Somatosensory1CTD_human
TgenePAMC0422852Seizures, Auditory1CTD_human
TgenePAMC0422853Olfactory seizure1CTD_human
TgenePAMC0422854Gustatory seizure1CTD_human
TgenePAMC0422855Vertiginous seizure1CTD_human
TgenePAMC0494475Tonic - clonic seizures1CTD_human
TgenePAMC0751056Non-epileptic convulsion1CTD_human
TgenePAMC0751110Single Seizure1CTD_human
TgenePAMC0751123Atonic Absence Seizures1CTD_human
TgenePAMC0751494Convulsive Seizures1CTD_human
TgenePAMC0751495Seizures, Focal1CTD_human
TgenePAMC0751496Seizures, Sensory1CTD_human
TgenePAMC1279420Anxiety neurosis (finding)1CTD_human
TgenePAMC3495874Nonepileptic Seizures1CTD_human
TgenePAMC4048158Convulsions1CTD_human
TgenePAMC4316903Absence Seizures1CTD_human
TgenePAMC4317109Epileptic Seizures1CTD_human
TgenePAMC4317123Myoclonic Seizures1CTD_human
TgenePAMC4505436Generalized Absence Seizures1CTD_human