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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GUK1-SMARCC1 (FusionGDB2 ID:35238)

Fusion Gene Summary for GUK1-SMARCC1

check button Fusion gene summary
Fusion gene informationFusion gene name: GUK1-SMARCC1
Fusion gene ID: 35238
HgeneTgene
Gene symbol

GUK1

SMARCC1

Gene ID

2987

6599

Gene nameguanylate kinase 1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
SynonymsGMKBAF155|CRACC1|Rsc8|SRG3|SWI3
Cytomap

1q42.13

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionguanylate kinaseATP:GMP phosphotransferaseGMP kinaseSWI/SNF complex subunit SMARCC1BRG1-associated factor 155SWI/SNF complex 155 kDa subunitSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1chromatin remodeling complex BAF155 subunitmammalian chromatin remode
Modification date2020032020200313
UniProtAcc

Q16774

.
Ensembl transtripts involved in fusion geneENST00000366730, ENST00000391865, 
ENST00000366726, ENST00000312726, 
ENST00000366728, ENST00000366723, 
ENST00000366722, ENST00000366721, 
ENST00000366718, ENST00000470040, 
ENST00000366716, 		ENST00000254480, 
ENST00000425518, 
Fusion gene scores* DoF score14 X 13 X 6=109218 X 18 X 8=2592
# samples 1624
** MAII scorelog2(16/1092*10)=-2.77082904603249
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/2592*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GUK1 [Title/Abstract] AND SMARCC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGUK1(228336090)-SMARCC1(47651631), # samples:1
Anticipated loss of major functional domain due to fusion event.GUK1-SMARCC1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GUK1-SMARCC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GUK1-SMARCC1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
GUK1-SMARCC1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGUK1

GO:0006163

purine nucleotide metabolic process

8663313

HgeneGUK1

GO:0006805

xenobiotic metabolic process

6306664

TgeneSMARCC1

GO:0006337

nucleosome disassembly

8895581

TgeneSMARCC1

GO:0006338

chromatin remodeling

10078207|11018012|11726552

TgeneSMARCC1

GO:0045893

positive regulation of transcription, DNA-templated

11018012


check buttonFusion gene breakpoints across GUK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SMARCC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI051269GUK1chr1

228336090

-SMARCC1chr3

47651631

-


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Fusion Gene ORF analysis for GUK1-SMARCC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000366730ENST00000254480GUK1chr1

228336090

-SMARCC1chr3

47651631

-
5CDS-5UTRENST00000366730ENST00000425518GUK1chr1

228336090

-SMARCC1chr3

47651631

-
In-frameENST00000391865ENST00000254480GUK1chr1

228336090

-SMARCC1chr3

47651631

-
5CDS-5UTRENST00000391865ENST00000425518GUK1chr1

228336090

-SMARCC1chr3

47651631

-
In-frameENST00000366726ENST00000254480GUK1chr1

228336090

-SMARCC1chr3

47651631

-
5CDS-5UTRENST00000366726ENST00000425518GUK1chr1

228336090

-SMARCC1chr3

47651631

-
In-frameENST00000312726ENST00000254480GUK1chr1

228336090

-SMARCC1chr3

47651631

-
5CDS-5UTRENST00000312726ENST00000425518GUK1chr1

228336090

-SMARCC1chr3

47651631

-
intron-3CDSENST00000366728ENST00000254480GUK1chr1

228336090

-SMARCC1chr3

47651631

-
intron-5UTRENST00000366728ENST00000425518GUK1chr1

228336090

-SMARCC1chr3

47651631

-
Frame-shiftENST00000366723ENST00000254480GUK1chr1

228336090

-SMARCC1chr3

47651631

-
5CDS-5UTRENST00000366723ENST00000425518GUK1chr1

228336090

-SMARCC1chr3

47651631

-
Frame-shiftENST00000366722ENST00000254480GUK1chr1

228336090

-SMARCC1chr3

47651631

-
5CDS-5UTRENST00000366722ENST00000425518GUK1chr1

228336090

-SMARCC1chr3

47651631

-
In-frameENST00000366721ENST00000254480GUK1chr1

228336090

-SMARCC1chr3

47651631

-
5CDS-5UTRENST00000366721ENST00000425518GUK1chr1

228336090

-SMARCC1chr3

47651631

-
In-frameENST00000366718ENST00000254480GUK1chr1

228336090

-SMARCC1chr3

47651631

-
5CDS-5UTRENST00000366718ENST00000425518GUK1chr1

228336090

-SMARCC1chr3

47651631

-
3UTR-3CDSENST00000470040ENST00000254480GUK1chr1

228336090

-SMARCC1chr3

47651631

-
3UTR-5UTRENST00000470040ENST00000425518GUK1chr1

228336090

-SMARCC1chr3

47651631

-
In-frameENST00000366716ENST00000254480GUK1chr1

228336090

-SMARCC1chr3

47651631

-
5CDS-5UTRENST00000366716ENST00000425518GUK1chr1

228336090

-SMARCC1chr3

47651631

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366730GUK1chr1228336090-ENST00000254480SMARCC1chr347651631-4030742200724174
ENST00000391865GUK1chr1228336090-ENST00000254480SMARCC1chr347651631-396868036662208
ENST00000366726GUK1chr1228336090-ENST00000254480SMARCC1chr347651631-392663842620192
ENST00000312726GUK1chr1228336090-ENST00000254480SMARCC1chr347651631-4071783205765186
ENST00000366721GUK1chr1228336090-ENST00000254480SMARCC1chr347651631-387058210564184
ENST00000366718GUK1chr1228336090-ENST00000254480SMARCC1chr347651631-4257969394951185
ENST00000366716GUK1chr1228336090-ENST00000254480SMARCC1chr347651631-388960159583174

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366730ENST00000254480GUK1chr1228336090-SMARCC1chr347651631-0.0044986250.99550134
ENST00000391865ENST00000254480GUK1chr1228336090-SMARCC1chr347651631-0.0054472490.9945528
ENST00000366726ENST00000254480GUK1chr1228336090-SMARCC1chr347651631-0.0046247510.9953753
ENST00000312726ENST00000254480GUK1chr1228336090-SMARCC1chr347651631-0.0047968120.99520314
ENST00000366721ENST00000254480GUK1chr1228336090-SMARCC1chr347651631-0.006733760.9932662
ENST00000366718ENST00000254480GUK1chr1228336090-SMARCC1chr347651631-0.0058416580.9941584
ENST00000366716ENST00000254480GUK1chr1228336090-SMARCC1chr347651631-0.0046098040.9953902

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Fusion Genomic Features for GUK1-SMARCC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GUK1-SMARCC1


check button Go to

FGviewer for the breakpoints of chr1:228336090-chr3:47651631

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GUK1

Q16774

.
FUNCTION: Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664). {ECO:0000250|UniProtKB:P46195, ECO:0000269|PubMed:197968, ECO:0000269|PubMed:31201273, ECO:0000269|PubMed:6248551, ECO:0000269|PubMed:6306664}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSMARCC1chr1:228336090chr3:47651631ENST00000254480028914_94601106.0Coiled coilOntology_term=ECO:0000255
TgeneSMARCC1chr1:228336090chr3:47651631ENST00000254480028329_33601106.0Compositional biasNote=Poly-Pro
TgeneSMARCC1chr1:228336090chr3:47651631ENST00000254480028769_86301106.0Compositional biasNote=Glu-rich
TgeneSMARCC1chr1:228336090chr3:47651631ENST00000254480028867_87801106.0Compositional biasNote=Poly-Ala
TgeneSMARCC1chr1:228336090chr3:47651631ENST00000254480028977_110501106.0Compositional biasNote=Pro-rich
TgeneSMARCC1chr1:228336090chr3:47651631ENST00000254480028449_54601106.0DomainSWIRM
TgeneSMARCC1chr1:228336090chr3:47651631ENST00000254480028618_66901106.0DomainSANT

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGUK1chr1:228336090chr3:47651631ENST00000312726-194_1860198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228336090chr3:47651631ENST00000366716-174_1860198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228336090chr3:47651631ENST00000366718-184_1860198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228336090chr3:47651631ENST00000366726-184_1860198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228336090chr3:47651631ENST00000366728-174_1860242.0DomainGuanylate kinase-like
HgeneGUK1chr1:228336090chr3:47651631ENST00000366730-184_1860198.0DomainGuanylate kinase-like
HgeneGUK1chr1:228336090chr3:47651631ENST00000391865-184_1860219.0DomainGuanylate kinase-like
HgeneGUK1chr1:228336090chr3:47651631ENST00000312726-1914_190198.0Nucleotide bindingATP
HgeneGUK1chr1:228336090chr3:47651631ENST00000312726-19171_1720198.0Nucleotide bindingATP
HgeneGUK1chr1:228336090chr3:47651631ENST00000312726-1937_510198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228336090chr3:47651631ENST00000366716-1714_190198.0Nucleotide bindingATP
HgeneGUK1chr1:228336090chr3:47651631ENST00000366716-17171_1720198.0Nucleotide bindingATP
HgeneGUK1chr1:228336090chr3:47651631ENST00000366716-1737_510198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228336090chr3:47651631ENST00000366718-1814_190198.0Nucleotide bindingATP
HgeneGUK1chr1:228336090chr3:47651631ENST00000366718-18171_1720198.0Nucleotide bindingATP
HgeneGUK1chr1:228336090chr3:47651631ENST00000366718-1837_510198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228336090chr3:47651631ENST00000366726-1814_190198.0Nucleotide bindingATP
HgeneGUK1chr1:228336090chr3:47651631ENST00000366726-18171_1720198.0Nucleotide bindingATP
HgeneGUK1chr1:228336090chr3:47651631ENST00000366726-1837_510198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228336090chr3:47651631ENST00000366728-1714_190242.0Nucleotide bindingATP
HgeneGUK1chr1:228336090chr3:47651631ENST00000366728-17171_1720242.0Nucleotide bindingATP
HgeneGUK1chr1:228336090chr3:47651631ENST00000366728-1737_510242.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228336090chr3:47651631ENST00000366730-1814_190198.0Nucleotide bindingATP
HgeneGUK1chr1:228336090chr3:47651631ENST00000366730-18171_1720198.0Nucleotide bindingATP
HgeneGUK1chr1:228336090chr3:47651631ENST00000366730-1837_510198.0Nucleotide bindingSubstrate binding
HgeneGUK1chr1:228336090chr3:47651631ENST00000391865-1814_190219.0Nucleotide bindingATP
HgeneGUK1chr1:228336090chr3:47651631ENST00000391865-18171_1720219.0Nucleotide bindingATP
HgeneGUK1chr1:228336090chr3:47651631ENST00000391865-1837_510219.0Nucleotide bindingSubstrate binding


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Fusion Gene Sequence for GUK1-SMARCC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000366730_ENST00000254480_BI051269_GUK1_chr1_228336090_-_SMARCC1_chr3_47651631_length(transcript)=4030nt_BP=742nt
CTTCTCTGAGTGACAAGCGGGACAAGTACGCCGTGGGCGGGGCCGGCGGGTCGTGATGTTAGTTCGCGCTGTGTGGAGGCGGGCCGGCGT
GGCGCTGTGACGCAGCGGGAGAAGACGGGCTGGGAGGGCGCTGTGCTGAACGCCCCTGCGGTCGCGACAGGCCAGCGCAGGTGGAGGCGG
GGCTAGCGAGGCACTGAGGCATGTCGGGCCCCAGGCCTGTGGTGCTGAGCGGGCCTTCGGGAGCTGGGAAGAGCACCCTGCTGAAGAGGC
TGCTCCAGGAGCACAGCGGCATCTTTGGCTTCAGCGTGTCCCATACCACGAGGAACCCGAGGCCCGGCGAGGAGAACGGCAAAGATTACT
ACTTTGTAACCAGGGAGGTGATGCAGCGTGACATAGCAGCCGGCGACTTCATCGAGCATGCCGAGTTCTCGGGGAACCTGTATGGCACGA
GCAAGGTGGCGGTGCAGGCCGTGCAGGCCATGAACCGCATCTGTGTGCTGGACGTGGACCTGCAGGGTGTGCGGAACATCAAGGCCACCG
ATCTGCGGCCCATCTACATCTCTGTGCAGCCGCCTTCACTGCACGTGCTGGAGCAGCGGCTGCGGCAGCGCAACACTGAAACCGAGGAGA
GCCTGGTGAAGCGGCTGGCTGCTGCCCAGGCCGACATGGAGAGCATGATGTGGTCATCATTAACGACAGCCTGGACCAGGCCTACGCAGA
GCTGAAGGAGGCGCTCTCTGAGATCCCCCTCCACCACAGCAGCAGCCACCGCCACCACCACCTGCAGATGGGGTCCCTCCGCCTCCTGCT
CCTGGCCCGCCAGCCTCAGCTGCTCCTTAGCCTGGAAGATGCAGGGAACCTCCACGCCCACCACCATGAGCTGGAGTGGGGATGACAAGA
CTTGTGTTCCTCAACTTTCTTGGGTTTCTTTCAGGATTTTTCTTCTCACAGCTCCAAGCACGTGTCCCGTGCCTCCCCACTCCTCTTACC
ACCCCTCTCTCTGACACTTTTTGTGTTGGGTCCTCAGCCAACACTCAAGGGGAAACCTGTAGTGACAGTGTGCCCTGGTCATCCTTAAAA
TAACCTGCATCTCCCCTGTCCTGGTGTGGGAGTAAGCTGACAGTTTCTCTGCAGGTCCTGTCAACTTTAGCATGCTATGTCTTTACCATT
TTTGCTCTCTTGCAGTTTTTTGCTTTGTCTTATGCTTCTATGGATAATGCTATATAATCATTATCTTTTTATCTTTCTGTTATTATTGTT
TTAAAGGAGAGCATCCTAAGTTAATAGGAACCAAAAAATAATGATGGGCAGAAGGGGGGGAATAGCCACAGGGGACAAACCTTAAGGCAT
TATAAGTGACCTTATTTCTGCTTTTCTGAGCTAAGAATGGTGCTGATGGTAAAGTTTGAGACTTTTGCCACACACAAATTTGTGAAAATT
AAACGAGATGTGGAAGGAGAACCTCAGTGATTTTATTCCCTAGTGAGGCCTCTGAGGGCCTCCACACTGCCTGGCAGAACATACCACTGA
ACTAGTATGTGCTAGAGGAGGGCACAAACATCCGCTCCTTCCCTAGGCCTGCTGGCTCTGGTTTTCTATGCAGATGATTCATTGGATTGG
GGGTGAGTGTTTTGTTTTTCTGGGGGCAGTGTGAGCTTTGAGGGTTGGAATATTGGGAGGCATTCCTTAGTTTCCTCAACTAGCCTGGAA
AGTTAGGAGTCTAGGGTAATTACCCCCAATGAGTCTAGCCTACTATTCACTGCTTTGTGTGCATTTTTTTCTCCCTCTTTAAAAAACCCT
TTAAAAGAAAAAAAAAAGTAGATAGTGCTAAATATTTTAGCTCATGAAACTTGGTTAGGATGGCTGGGGGTACAAGTCCCCAAACTACCT
CTTGTTACAGTAGCCAGGGAGTGGAATTTCGTCAACCGGTACTTTTAAGGTTAGGATGGGACGGGAAAAGTGAAGCAGGATATTAGCTCC
TTATACCTTCTCCCTTCCATTTCTGAGATCTCACATTCCATCTATCACAGGGTTTTCAAAGAGATGCTGAGGGTAACAAGGAACTCACTT
GGCAGTCAGAGCATCATGCTTTGAGGTTTGGGGTGCTCAGGCTGGGAGGGTAGAATGCCATTCCAGAGGACAAGCCACAAAAATGCCTTA
ATTTGAGCTCGTATTTACCCCTGCTGATAAGTGACTTGAGAGTTCCCGGTTTTTTCCTCTTGTCCTTCCCTCCCTTCTGTCCTTCCATGT
GTGGGGAAAGGGTGTTTTTGGTAGAGCTTGGTTTCCAAAGCGCCTGGCTTTCTCACTTCACATTCTCAAGTGGCAGTTTCATTATTTAGA
ATGCAAGGTGGACATCTTTTGGATATCTTTTTCTATATATTTTCTAAAGCTTTACATATGAGAGGGTATAGGGAGGTGTTTATAAAACAC
TTGAGAACTTTTTTCCTTAATATCAGAAAGCAAAAAAATAAAACCACAATTGAGATTTGCCTTTCAAACCCTCAGGTTTGCCTCTAACCA
GGTGTCCCTGGTCACCATCAGAGTACTGGAATACGGGAACCGAGGAGACCTTGGTCCTTTTGTTTTTGTTCTGGACTCTTGGGAGTGGAA
ATGAGAATGAGTTTATTCCTACTGGAGCTTAGTTCCAATGCATTTGGCTCCAGAAAGACCCCAGTGCCTTTTGACAATGGCCAGGGTTTT
ACCTACTTCCTGCCAGTCTTTCCCAAAGGAAACTCATTCCAAATACTTCTTTTTTCCCCTGGAGTCCGAGAAGGAAAATGGAATTCTGGT
TCATACTGTGGTCCCTTGTAACCTCAGGTCTTTAATGTGATCACTTTCAAATTTAAAAGATCCAGGTGGAAATATTTTTACTATAGTAAT
AATTCTACAAAATACCTGAATTCTTAACACTGTTATATTTCAGTATAAGTGGTGGCTTTTTCTTTTCATGTCTTTGATCTGGTTTTATTC
CTGTAATTCAGCCACCTGATTTTGTGAGGGGGGGGAATAATATGTGGTTTTTGTACAAACATGTTTCTCAGTGTGTTGTTATTTTGGAAA
AAATGAGGGGAGGGAGTTTGGCAAGAATGGAGAAAATGAATGAAGAAGGCCTAATCTCTCTCTTTTTCAGTGAATAAATGGAACACCATT
TCTGGATTCTAGTCCCATTCTCTGCATTCATACACCAGTTTCTTCATATATCCTATGAAGAACCTAAACATTTGGCCCCACCTGGTCTTG
GTTTGATCAGCAGTTAAAATTCTGTGACTCGGGCTTCCTTCCCGACTGCCCACCTTCATGATGTGTAAGGAACATACATTTTGAGGGTAC
CTCACCCACTGTTCATTTGCATGGTCAAAGTGAAAATGAGTGGAAGTTCTCCAAAAATGATGGCCAACATCCTGGCACCTCCAGGTGTGA
GAAATAGCTTTGCTTGGTGAATGGGATAATGTTTGTCAGGATGCAGTTTAGACAGTCCCAAGTTGGAGGCAGGCCTTGAGGGCAGAAGAT
TCTGTGAACCTTGGGGGACAGCTTTTGGGTACTCACAGATATAAACCCTGTGCAGAAAAAAAGAAGTGATTGTTTTCAGGATGCTTATAA
ATCGAGTGAAGCAAAAGAAGAGGATTCTGTGTCTGCCATGAGATGAACGCCCTGCTCTTCACGAAGGTGTGCCTCTAATAAAGAGAGCCA
AAGCCAGCTGGGTCTCACCAGATTCCTATACTTTCTCAAGGATGTTGGGGGAGGTTAATCCTTTATCGAAACTAAAGACTGGTTTATGTC
AGATACCAGGCCCAGGTTCCATGATGCCCGGGCAGCACATGCCAGGCCGCATGATTCCCACTGTTGCAGCCAACATCCACCCCTCTGGGA
GTGGCCCTACCCCTCCTGGCATGCCACCAATGCCAGGAAACATCTTAGGACCCCGGGTACCCCTGACAGCACCTAACGGCATGTATGATG

>In-frame_ENST00000366730_ENST00000254480_BI051269_GUK1_chr1_228336090_-_SMARCC1_chr3_47651631_length(amino acids)=174AA_start in transcript=200_stop in transcript=724
MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQA

--------------------------------------------------------------
>In-frame_ENST00000391865_ENST00000254480_BI051269_GUK1_chr1_228336090_-_SMARCC1_chr3_47651631_length(transcript)=3968nt_BP=680nt
AGTCTCGCGCGCGGGCGGAGGTGGGCCGGTGCGGCGCTGTCACGTAGGTTCAGTGGGCGGAAGAGGTGGCCCCGGATGCTGCGGCGCCCG
CTGGCCGGGCTGGCTGCGGCCGCCCTGGGCCGGGCCCCACCGGACGGCATGTCGGGCCCCAGGCCTGTGGTGCTGAGCGGGCCTTCGGGA
GCTGGGAAGAGCACCCTGCTGAAGAGGCTGCTCCAGGAGCACAGCGGCATCTTTGGCTTCAGCGTGTCCCATACCACGAGGAACCCGAGG
CCCGGCGAGGAGAACGGCAAAGATTACTACTTTGTAACCAGGGAGGTGATGCAGCGTGACATAGCAGCCGGCGACTTCATCGAGCATGCC
GAGTTCTCGGGGAACCTGTATGGCACGAGCAAGGTGGCGGTGCAGGCCGTGCAGGCCATGAACCGCATCTGTGTGCTGGACGTGGACCTG
CAGGGTGTGCGGAACATCAAGGCCACCGATCTGCGGCCCATCTACATCTCTGTGCAGCCGCCTTCACTGCACGTGCTGGAGCAGCGGCTG
CGGCAGCGCAACACTGAAACCGAGGAGAGCCTGGTGAAGCGGCTGGCTGCTGCCCAGGCCGACATGGAGAGCATGATGTGGTCATCATTA
ACGACAGCCTGGACCAGGCCTACGCAGAGCTGAAGGAGGCGCTCTCTGAGATCCCCCTCCACCACAGCAGCAGCCACCGCCACCACCACC
TGCAGATGGGGTCCCTCCGCCTCCTGCTCCTGGCCCGCCAGCCTCAGCTGCTCCTTAGCCTGGAAGATGCAGGGAACCTCCACGCCCACC
ACCATGAGCTGGAGTGGGGATGACAAGACTTGTGTTCCTCAACTTTCTTGGGTTTCTTTCAGGATTTTTCTTCTCACAGCTCCAAGCACG
TGTCCCGTGCCTCCCCACTCCTCTTACCACCCCTCTCTCTGACACTTTTTGTGTTGGGTCCTCAGCCAACACTCAAGGGGAAACCTGTAG
TGACAGTGTGCCCTGGTCATCCTTAAAATAACCTGCATCTCCCCTGTCCTGGTGTGGGAGTAAGCTGACAGTTTCTCTGCAGGTCCTGTC
AACTTTAGCATGCTATGTCTTTACCATTTTTGCTCTCTTGCAGTTTTTTGCTTTGTCTTATGCTTCTATGGATAATGCTATATAATCATT
ATCTTTTTATCTTTCTGTTATTATTGTTTTAAAGGAGAGCATCCTAAGTTAATAGGAACCAAAAAATAATGATGGGCAGAAGGGGGGGAA
TAGCCACAGGGGACAAACCTTAAGGCATTATAAGTGACCTTATTTCTGCTTTTCTGAGCTAAGAATGGTGCTGATGGTAAAGTTTGAGAC
TTTTGCCACACACAAATTTGTGAAAATTAAACGAGATGTGGAAGGAGAACCTCAGTGATTTTATTCCCTAGTGAGGCCTCTGAGGGCCTC
CACACTGCCTGGCAGAACATACCACTGAACTAGTATGTGCTAGAGGAGGGCACAAACATCCGCTCCTTCCCTAGGCCTGCTGGCTCTGGT
TTTCTATGCAGATGATTCATTGGATTGGGGGTGAGTGTTTTGTTTTTCTGGGGGCAGTGTGAGCTTTGAGGGTTGGAATATTGGGAGGCA
TTCCTTAGTTTCCTCAACTAGCCTGGAAAGTTAGGAGTCTAGGGTAATTACCCCCAATGAGTCTAGCCTACTATTCACTGCTTTGTGTGC
ATTTTTTTCTCCCTCTTTAAAAAACCCTTTAAAAGAAAAAAAAAAGTAGATAGTGCTAAATATTTTAGCTCATGAAACTTGGTTAGGATG
GCTGGGGGTACAAGTCCCCAAACTACCTCTTGTTACAGTAGCCAGGGAGTGGAATTTCGTCAACCGGTACTTTTAAGGTTAGGATGGGAC
GGGAAAAGTGAAGCAGGATATTAGCTCCTTATACCTTCTCCCTTCCATTTCTGAGATCTCACATTCCATCTATCACAGGGTTTTCAAAGA
GATGCTGAGGGTAACAAGGAACTCACTTGGCAGTCAGAGCATCATGCTTTGAGGTTTGGGGTGCTCAGGCTGGGAGGGTAGAATGCCATT
CCAGAGGACAAGCCACAAAAATGCCTTAATTTGAGCTCGTATTTACCCCTGCTGATAAGTGACTTGAGAGTTCCCGGTTTTTTCCTCTTG
TCCTTCCCTCCCTTCTGTCCTTCCATGTGTGGGGAAAGGGTGTTTTTGGTAGAGCTTGGTTTCCAAAGCGCCTGGCTTTCTCACTTCACA
TTCTCAAGTGGCAGTTTCATTATTTAGAATGCAAGGTGGACATCTTTTGGATATCTTTTTCTATATATTTTCTAAAGCTTTACATATGAG
AGGGTATAGGGAGGTGTTTATAAAACACTTGAGAACTTTTTTCCTTAATATCAGAAAGCAAAAAAATAAAACCACAATTGAGATTTGCCT
TTCAAACCCTCAGGTTTGCCTCTAACCAGGTGTCCCTGGTCACCATCAGAGTACTGGAATACGGGAACCGAGGAGACCTTGGTCCTTTTG
TTTTTGTTCTGGACTCTTGGGAGTGGAAATGAGAATGAGTTTATTCCTACTGGAGCTTAGTTCCAATGCATTTGGCTCCAGAAAGACCCC
AGTGCCTTTTGACAATGGCCAGGGTTTTACCTACTTCCTGCCAGTCTTTCCCAAAGGAAACTCATTCCAAATACTTCTTTTTTCCCCTGG
AGTCCGAGAAGGAAAATGGAATTCTGGTTCATACTGTGGTCCCTTGTAACCTCAGGTCTTTAATGTGATCACTTTCAAATTTAAAAGATC
CAGGTGGAAATATTTTTACTATAGTAATAATTCTACAAAATACCTGAATTCTTAACACTGTTATATTTCAGTATAAGTGGTGGCTTTTTC
TTTTCATGTCTTTGATCTGGTTTTATTCCTGTAATTCAGCCACCTGATTTTGTGAGGGGGGGGAATAATATGTGGTTTTTGTACAAACAT
GTTTCTCAGTGTGTTGTTATTTTGGAAAAAATGAGGGGAGGGAGTTTGGCAAGAATGGAGAAAATGAATGAAGAAGGCCTAATCTCTCTC
TTTTTCAGTGAATAAATGGAACACCATTTCTGGATTCTAGTCCCATTCTCTGCATTCATACACCAGTTTCTTCATATATCCTATGAAGAA
CCTAAACATTTGGCCCCACCTGGTCTTGGTTTGATCAGCAGTTAAAATTCTGTGACTCGGGCTTCCTTCCCGACTGCCCACCTTCATGAT
GTGTAAGGAACATACATTTTGAGGGTACCTCACCCACTGTTCATTTGCATGGTCAAAGTGAAAATGAGTGGAAGTTCTCCAAAAATGATG
GCCAACATCCTGGCACCTCCAGGTGTGAGAAATAGCTTTGCTTGGTGAATGGGATAATGTTTGTCAGGATGCAGTTTAGACAGTCCCAAG
TTGGAGGCAGGCCTTGAGGGCAGAAGATTCTGTGAACCTTGGGGGACAGCTTTTGGGTACTCACAGATATAAACCCTGTGCAGAAAAAAA
GAAGTGATTGTTTTCAGGATGCTTATAAATCGAGTGAAGCAAAAGAAGAGGATTCTGTGTCTGCCATGAGATGAACGCCCTGCTCTTCAC
GAAGGTGTGCCTCTAATAAAGAGAGCCAAAGCCAGCTGGGTCTCACCAGATTCCTATACTTTCTCAAGGATGTTGGGGGAGGTTAATCCT
TTATCGAAACTAAAGACTGGTTTATGTCAGATACCAGGCCCAGGTTCCATGATGCCCGGGCAGCACATGCCAGGCCGCATGATTCCCACT
GTTGCAGCCAACATCCACCCCTCTGGGAGTGGCCCTACCCCTCCTGGCATGCCACCAATGCCAGGAAACATCTTAGGACCCCGGGTACCC
CTGACAGCACCTAACGGCATGTATGATGCCTCATCAACAGCCCCCTCCCTACCCTCTGATGCACCACCAGATGCCACCACCTCATCCACC

>In-frame_ENST00000391865_ENST00000254480_BI051269_GUK1_chr1_228336090_-_SMARCC1_chr3_47651631_length(amino acids)=208AA_start in transcript=36_stop in transcript=662
MSRRFSGRKRWPRMLRRPLAGLAAAALGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV
TREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLV

--------------------------------------------------------------
>In-frame_ENST00000366726_ENST00000254480_BI051269_GUK1_chr1_228336090_-_SMARCC1_chr3_47651631_length(transcript)=3926nt_BP=638nt
AGAGGTGGCCCCGGATGCTGCGGCGCCCGCTGGCCGGGCTGGCTGCGGCCGCCCTGGGCCGGGCCCCACCGGACGCCTCTCTTCTCACCC
CCAGGCATGTCGGGCCCCAGGCCTGTGGTGCTGAGCGGGCCTTCGGGAGCTGGGAAGAGCACCCTGCTGAAGAGGCTGCTCCAGGAGCAC
AGCGGCATCTTTGGCTTCAGCGTGTCCCATACCACGAGGAACCCGAGGCCCGGCGAGGAGAACGGCAAAGATTACTACTTTGTAACCAGG
GAGGTGATGCAGCGTGACATAGCAGCCGGCGACTTCATCGAGCATGCCGAGTTCTCGGGGAACCTGTATGGCACGAGCAAGGTGGCGGTG
CAGGCCGTGCAGGCCATGAACCGCATCTGTGTGCTGGACGTGGACCTGCAGGGTGTGCGGAACATCAAGGCCACCGATCTGCGGCCCATC
TACATCTCTGTGCAGCCGCCTTCACTGCACGTGCTGGAGCAGCGGCTGCGGCAGCGCAACACTGAAACCGAGGAGAGCCTGGTGAAGCGG
CTGGCTGCTGCCCAGGCCGACATGGAGAGCATGATGTGGTCATCATTAACGACAGCCTGGACCAGGCCTACGCAGAGCTGAAGGAGGCGC
TCTCTGAGATCCCCCTCCACCACAGCAGCAGCCACCGCCACCACCACCTGCAGATGGGGTCCCTCCGCCTCCTGCTCCTGGCCCGCCAGC
CTCAGCTGCTCCTTAGCCTGGAAGATGCAGGGAACCTCCACGCCCACCACCATGAGCTGGAGTGGGGATGACAAGACTTGTGTTCCTCAA
CTTTCTTGGGTTTCTTTCAGGATTTTTCTTCTCACAGCTCCAAGCACGTGTCCCGTGCCTCCCCACTCCTCTTACCACCCCTCTCTCTGA
CACTTTTTGTGTTGGGTCCTCAGCCAACACTCAAGGGGAAACCTGTAGTGACAGTGTGCCCTGGTCATCCTTAAAATAACCTGCATCTCC
CCTGTCCTGGTGTGGGAGTAAGCTGACAGTTTCTCTGCAGGTCCTGTCAACTTTAGCATGCTATGTCTTTACCATTTTTGCTCTCTTGCA
GTTTTTTGCTTTGTCTTATGCTTCTATGGATAATGCTATATAATCATTATCTTTTTATCTTTCTGTTATTATTGTTTTAAAGGAGAGCAT
CCTAAGTTAATAGGAACCAAAAAATAATGATGGGCAGAAGGGGGGGAATAGCCACAGGGGACAAACCTTAAGGCATTATAAGTGACCTTA
TTTCTGCTTTTCTGAGCTAAGAATGGTGCTGATGGTAAAGTTTGAGACTTTTGCCACACACAAATTTGTGAAAATTAAACGAGATGTGGA
AGGAGAACCTCAGTGATTTTATTCCCTAGTGAGGCCTCTGAGGGCCTCCACACTGCCTGGCAGAACATACCACTGAACTAGTATGTGCTA
GAGGAGGGCACAAACATCCGCTCCTTCCCTAGGCCTGCTGGCTCTGGTTTTCTATGCAGATGATTCATTGGATTGGGGGTGAGTGTTTTG
TTTTTCTGGGGGCAGTGTGAGCTTTGAGGGTTGGAATATTGGGAGGCATTCCTTAGTTTCCTCAACTAGCCTGGAAAGTTAGGAGTCTAG
GGTAATTACCCCCAATGAGTCTAGCCTACTATTCACTGCTTTGTGTGCATTTTTTTCTCCCTCTTTAAAAAACCCTTTAAAAGAAAAAAA
AAAGTAGATAGTGCTAAATATTTTAGCTCATGAAACTTGGTTAGGATGGCTGGGGGTACAAGTCCCCAAACTACCTCTTGTTACAGTAGC
CAGGGAGTGGAATTTCGTCAACCGGTACTTTTAAGGTTAGGATGGGACGGGAAAAGTGAAGCAGGATATTAGCTCCTTATACCTTCTCCC
TTCCATTTCTGAGATCTCACATTCCATCTATCACAGGGTTTTCAAAGAGATGCTGAGGGTAACAAGGAACTCACTTGGCAGTCAGAGCAT
CATGCTTTGAGGTTTGGGGTGCTCAGGCTGGGAGGGTAGAATGCCATTCCAGAGGACAAGCCACAAAAATGCCTTAATTTGAGCTCGTAT
TTACCCCTGCTGATAAGTGACTTGAGAGTTCCCGGTTTTTTCCTCTTGTCCTTCCCTCCCTTCTGTCCTTCCATGTGTGGGGAAAGGGTG
TTTTTGGTAGAGCTTGGTTTCCAAAGCGCCTGGCTTTCTCACTTCACATTCTCAAGTGGCAGTTTCATTATTTAGAATGCAAGGTGGACA
TCTTTTGGATATCTTTTTCTATATATTTTCTAAAGCTTTACATATGAGAGGGTATAGGGAGGTGTTTATAAAACACTTGAGAACTTTTTT
CCTTAATATCAGAAAGCAAAAAAATAAAACCACAATTGAGATTTGCCTTTCAAACCCTCAGGTTTGCCTCTAACCAGGTGTCCCTGGTCA
CCATCAGAGTACTGGAATACGGGAACCGAGGAGACCTTGGTCCTTTTGTTTTTGTTCTGGACTCTTGGGAGTGGAAATGAGAATGAGTTT
ATTCCTACTGGAGCTTAGTTCCAATGCATTTGGCTCCAGAAAGACCCCAGTGCCTTTTGACAATGGCCAGGGTTTTACCTACTTCCTGCC
AGTCTTTCCCAAAGGAAACTCATTCCAAATACTTCTTTTTTCCCCTGGAGTCCGAGAAGGAAAATGGAATTCTGGTTCATACTGTGGTCC
CTTGTAACCTCAGGTCTTTAATGTGATCACTTTCAAATTTAAAAGATCCAGGTGGAAATATTTTTACTATAGTAATAATTCTACAAAATA
CCTGAATTCTTAACACTGTTATATTTCAGTATAAGTGGTGGCTTTTTCTTTTCATGTCTTTGATCTGGTTTTATTCCTGTAATTCAGCCA
CCTGATTTTGTGAGGGGGGGGAATAATATGTGGTTTTTGTACAAACATGTTTCTCAGTGTGTTGTTATTTTGGAAAAAATGAGGGGAGGG
AGTTTGGCAAGAATGGAGAAAATGAATGAAGAAGGCCTAATCTCTCTCTTTTTCAGTGAATAAATGGAACACCATTTCTGGATTCTAGTC
CCATTCTCTGCATTCATACACCAGTTTCTTCATATATCCTATGAAGAACCTAAACATTTGGCCCCACCTGGTCTTGGTTTGATCAGCAGT
TAAAATTCTGTGACTCGGGCTTCCTTCCCGACTGCCCACCTTCATGATGTGTAAGGAACATACATTTTGAGGGTACCTCACCCACTGTTC
ATTTGCATGGTCAAAGTGAAAATGAGTGGAAGTTCTCCAAAAATGATGGCCAACATCCTGGCACCTCCAGGTGTGAGAAATAGCTTTGCT
TGGTGAATGGGATAATGTTTGTCAGGATGCAGTTTAGACAGTCCCAAGTTGGAGGCAGGCCTTGAGGGCAGAAGATTCTGTGAACCTTGG
GGGACAGCTTTTGGGTACTCACAGATATAAACCCTGTGCAGAAAAAAAGAAGTGATTGTTTTCAGGATGCTTATAAATCGAGTGAAGCAA
AAGAAGAGGATTCTGTGTCTGCCATGAGATGAACGCCCTGCTCTTCACGAAGGTGTGCCTCTAATAAAGAGAGCCAAAGCCAGCTGGGTC
TCACCAGATTCCTATACTTTCTCAAGGATGTTGGGGGAGGTTAATCCTTTATCGAAACTAAAGACTGGTTTATGTCAGATACCAGGCCCA
GGTTCCATGATGCCCGGGCAGCACATGCCAGGCCGCATGATTCCCACTGTTGCAGCCAACATCCACCCCTCTGGGAGTGGCCCTACCCCT
CCTGGCATGCCACCAATGCCAGGAAACATCTTAGGACCCCGGGTACCCCTGACAGCACCTAACGGCATGTATGATGCCTCATCAACAGCC

>In-frame_ENST00000366726_ENST00000254480_BI051269_GUK1_chr1_228336090_-_SMARCC1_chr3_47651631_length(amino acids)=192AA_start in transcript=42_stop in transcript=620
MRPPWAGPHRTPLFSPPGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIE
HAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESMMWS

--------------------------------------------------------------
>In-frame_ENST00000312726_ENST00000254480_BI051269_GUK1_chr1_228336090_-_SMARCC1_chr3_47651631_length(transcript)=4071nt_BP=783nt
GAGGTGGCCCCGGATGCTGCGGCGCCCGCTGGCCGGGCTGGCTGCGGCCGCCCTGGGCCGGGCCCCACCGGACGGCTTGCTCTGCTCTTT
ACCTGGGGTTGCTGTCGAGGACCCTGTGCAAGACTCGGCCGGTTTTTCTTTCTCCCTGATGGACAGACCCAAACATAGCCGCGCAGCATC
GTGAAGGGCTGGGGCCTTCACTCCTCTGTGGCTCTGGAAGAGCCCGATTTCCTCAGGAGGCATGTCGGGCCCCAGGCCTGTGGTGCTGAG
CGGGCCTTCGGGAGCTGGGAAGAGCACCCTGCTGAAGAGGCTGCTCCAGGAGCACAGCGGCATCTTTGGCTTCAGCGTGTCCCATACCAC
GAGGAACCCGAGGCCCGGCGAGGAGAACGGCAAAGATTACTACTTTGTAACCAGGGAGGTGATGCAGCGTGACATAGCAGCCGGCGACTT
CATCGAGCATGCCGAGTTCTCGGGGAACCTGTATGGCACGAGCAAGGTGGCGGTGCAGGCCGTGCAGGCCATGAACCGCATCTGTGTGCT
GGACGTGGACCTGCAGGGTGTGCGGAACATCAAGGCCACCGATCTGCGGCCCATCTACATCTCTGTGCAGCCGCCTTCACTGCACGTGCT
GGAGCAGCGGCTGCGGCAGCGCAACACTGAAACCGAGGAGAGCCTGGTGAAGCGGCTGGCTGCTGCCCAGGCCGACATGGAGAGCATGAT
GTGGTCATCATTAACGACAGCCTGGACCAGGCCTACGCAGAGCTGAAGGAGGCGCTCTCTGAGATCCCCCTCCACCACAGCAGCAGCCAC
CGCCACCACCACCTGCAGATGGGGTCCCTCCGCCTCCTGCTCCTGGCCCGCCAGCCTCAGCTGCTCCTTAGCCTGGAAGATGCAGGGAAC
CTCCACGCCCACCACCATGAGCTGGAGTGGGGATGACAAGACTTGTGTTCCTCAACTTTCTTGGGTTTCTTTCAGGATTTTTCTTCTCAC
AGCTCCAAGCACGTGTCCCGTGCCTCCCCACTCCTCTTACCACCCCTCTCTCTGACACTTTTTGTGTTGGGTCCTCAGCCAACACTCAAG
GGGAAACCTGTAGTGACAGTGTGCCCTGGTCATCCTTAAAATAACCTGCATCTCCCCTGTCCTGGTGTGGGAGTAAGCTGACAGTTTCTC
TGCAGGTCCTGTCAACTTTAGCATGCTATGTCTTTACCATTTTTGCTCTCTTGCAGTTTTTTGCTTTGTCTTATGCTTCTATGGATAATG
CTATATAATCATTATCTTTTTATCTTTCTGTTATTATTGTTTTAAAGGAGAGCATCCTAAGTTAATAGGAACCAAAAAATAATGATGGGC
AGAAGGGGGGGAATAGCCACAGGGGACAAACCTTAAGGCATTATAAGTGACCTTATTTCTGCTTTTCTGAGCTAAGAATGGTGCTGATGG
TAAAGTTTGAGACTTTTGCCACACACAAATTTGTGAAAATTAAACGAGATGTGGAAGGAGAACCTCAGTGATTTTATTCCCTAGTGAGGC
CTCTGAGGGCCTCCACACTGCCTGGCAGAACATACCACTGAACTAGTATGTGCTAGAGGAGGGCACAAACATCCGCTCCTTCCCTAGGCC
TGCTGGCTCTGGTTTTCTATGCAGATGATTCATTGGATTGGGGGTGAGTGTTTTGTTTTTCTGGGGGCAGTGTGAGCTTTGAGGGTTGGA
ATATTGGGAGGCATTCCTTAGTTTCCTCAACTAGCCTGGAAAGTTAGGAGTCTAGGGTAATTACCCCCAATGAGTCTAGCCTACTATTCA
CTGCTTTGTGTGCATTTTTTTCTCCCTCTTTAAAAAACCCTTTAAAAGAAAAAAAAAAGTAGATAGTGCTAAATATTTTAGCTCATGAAA
CTTGGTTAGGATGGCTGGGGGTACAAGTCCCCAAACTACCTCTTGTTACAGTAGCCAGGGAGTGGAATTTCGTCAACCGGTACTTTTAAG
GTTAGGATGGGACGGGAAAAGTGAAGCAGGATATTAGCTCCTTATACCTTCTCCCTTCCATTTCTGAGATCTCACATTCCATCTATCACA
GGGTTTTCAAAGAGATGCTGAGGGTAACAAGGAACTCACTTGGCAGTCAGAGCATCATGCTTTGAGGTTTGGGGTGCTCAGGCTGGGAGG
GTAGAATGCCATTCCAGAGGACAAGCCACAAAAATGCCTTAATTTGAGCTCGTATTTACCCCTGCTGATAAGTGACTTGAGAGTTCCCGG
TTTTTTCCTCTTGTCCTTCCCTCCCTTCTGTCCTTCCATGTGTGGGGAAAGGGTGTTTTTGGTAGAGCTTGGTTTCCAAAGCGCCTGGCT
TTCTCACTTCACATTCTCAAGTGGCAGTTTCATTATTTAGAATGCAAGGTGGACATCTTTTGGATATCTTTTTCTATATATTTTCTAAAG
CTTTACATATGAGAGGGTATAGGGAGGTGTTTATAAAACACTTGAGAACTTTTTTCCTTAATATCAGAAAGCAAAAAAATAAAACCACAA
TTGAGATTTGCCTTTCAAACCCTCAGGTTTGCCTCTAACCAGGTGTCCCTGGTCACCATCAGAGTACTGGAATACGGGAACCGAGGAGAC
CTTGGTCCTTTTGTTTTTGTTCTGGACTCTTGGGAGTGGAAATGAGAATGAGTTTATTCCTACTGGAGCTTAGTTCCAATGCATTTGGCT
CCAGAAAGACCCCAGTGCCTTTTGACAATGGCCAGGGTTTTACCTACTTCCTGCCAGTCTTTCCCAAAGGAAACTCATTCCAAATACTTC
TTTTTTCCCCTGGAGTCCGAGAAGGAAAATGGAATTCTGGTTCATACTGTGGTCCCTTGTAACCTCAGGTCTTTAATGTGATCACTTTCA
AATTTAAAAGATCCAGGTGGAAATATTTTTACTATAGTAATAATTCTACAAAATACCTGAATTCTTAACACTGTTATATTTCAGTATAAG
TGGTGGCTTTTTCTTTTCATGTCTTTGATCTGGTTTTATTCCTGTAATTCAGCCACCTGATTTTGTGAGGGGGGGGAATAATATGTGGTT
TTTGTACAAACATGTTTCTCAGTGTGTTGTTATTTTGGAAAAAATGAGGGGAGGGAGTTTGGCAAGAATGGAGAAAATGAATGAAGAAGG
CCTAATCTCTCTCTTTTTCAGTGAATAAATGGAACACCATTTCTGGATTCTAGTCCCATTCTCTGCATTCATACACCAGTTTCTTCATAT
ATCCTATGAAGAACCTAAACATTTGGCCCCACCTGGTCTTGGTTTGATCAGCAGTTAAAATTCTGTGACTCGGGCTTCCTTCCCGACTGC
CCACCTTCATGATGTGTAAGGAACATACATTTTGAGGGTACCTCACCCACTGTTCATTTGCATGGTCAAAGTGAAAATGAGTGGAAGTTC
TCCAAAAATGATGGCCAACATCCTGGCACCTCCAGGTGTGAGAAATAGCTTTGCTTGGTGAATGGGATAATGTTTGTCAGGATGCAGTTT
AGACAGTCCCAAGTTGGAGGCAGGCCTTGAGGGCAGAAGATTCTGTGAACCTTGGGGGACAGCTTTTGGGTACTCACAGATATAAACCCT
GTGCAGAAAAAAAGAAGTGATTGTTTTCAGGATGCTTATAAATCGAGTGAAGCAAAAGAAGAGGATTCTGTGTCTGCCATGAGATGAACG
CCCTGCTCTTCACGAAGGTGTGCCTCTAATAAAGAGAGCCAAAGCCAGCTGGGTCTCACCAGATTCCTATACTTTCTCAAGGATGTTGGG
GGAGGTTAATCCTTTATCGAAACTAAAGACTGGTTTATGTCAGATACCAGGCCCAGGTTCCATGATGCCCGGGCAGCACATGCCAGGCCG
CATGATTCCCACTGTTGCAGCCAACATCCACCCCTCTGGGAGTGGCCCTACCCCTCCTGGCATGCCACCAATGCCAGGAAACATCTTAGG
ACCCCGGGTACCCCTGACAGCACCTAACGGCATGTATGATGCCTCATCAACAGCCCCCTCCCTACCCTCTGATGCACCACCAGATGCCAC

>In-frame_ENST00000312726_ENST00000254480_BI051269_GUK1_chr1_228336090_-_SMARCC1_chr3_47651631_length(amino acids)=186AA_start in transcript=205_stop in transcript=765
MWLWKSPISSGGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSG
NLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESMMWSSLTTAW

--------------------------------------------------------------
>In-frame_ENST00000366721_ENST00000254480_BI051269_GUK1_chr1_228336090_-_SMARCC1_chr3_47651631_length(transcript)=3870nt_BP=582nt
TGCGGCCGCCCTGGGCCGGGCCCCACCGGACGGCATGTCGGGCCCCAGGCCTGTGGTGCTGAGCGGGCCTTCGGGAGCTGGGAAGAGCAC
CCTGCTGAAGAGGCTGCTCCAGGAGCACAGCGGCATCTTTGGCTTCAGCGTGTCCCGTGAGTCCAGGGCTCTCGTGGAGGGATACCACGA
GGAACCCGAGGCCCGGCGAGGAGAACGGCAAAGGGAGGTGATGCAGCGTGACATAGCAGCCGGCGACTTCATCGAGCATGCCGAGTTCTC
GGGGAACCTGTATGGCACGAGCAAGGTGGCGGTGCAGGCCGTGCAGGCCATGAACCGCATCTGTGTGCTGGACGTGGACCTGCAGGGTGT
GCGGAACATCAAGGCCACCGATCTGCGGCCCATCTACATCTCTGTGCAGCCGCCTTCACTGCACGTGCTGGAGCAGCGGCTGCGGCAGCG
CAACACTGAAACCGAGGAGAGCCTGGTGAAGCGGCTGGCTGCTGCCCAGGCCGACATGGAGAGCATGATGTGGTCATCATTAACGACAGC
CTGGACCAGGCCTACGCAGAGCTGAAGGAGGCGCTCTCTGAGATCCCCCTCCACCACAGCAGCAGCCACCGCCACCACCACCTGCAGATG
GGGTCCCTCCGCCTCCTGCTCCTGGCCCGCCAGCCTCAGCTGCTCCTTAGCCTGGAAGATGCAGGGAACCTCCACGCCCACCACCATGAG
CTGGAGTGGGGATGACAAGACTTGTGTTCCTCAACTTTCTTGGGTTTCTTTCAGGATTTTTCTTCTCACAGCTCCAAGCACGTGTCCCGT
GCCTCCCCACTCCTCTTACCACCCCTCTCTCTGACACTTTTTGTGTTGGGTCCTCAGCCAACACTCAAGGGGAAACCTGTAGTGACAGTG
TGCCCTGGTCATCCTTAAAATAACCTGCATCTCCCCTGTCCTGGTGTGGGAGTAAGCTGACAGTTTCTCTGCAGGTCCTGTCAACTTTAG
CATGCTATGTCTTTACCATTTTTGCTCTCTTGCAGTTTTTTGCTTTGTCTTATGCTTCTATGGATAATGCTATATAATCATTATCTTTTT
ATCTTTCTGTTATTATTGTTTTAAAGGAGAGCATCCTAAGTTAATAGGAACCAAAAAATAATGATGGGCAGAAGGGGGGGAATAGCCACA
GGGGACAAACCTTAAGGCATTATAAGTGACCTTATTTCTGCTTTTCTGAGCTAAGAATGGTGCTGATGGTAAAGTTTGAGACTTTTGCCA
CACACAAATTTGTGAAAATTAAACGAGATGTGGAAGGAGAACCTCAGTGATTTTATTCCCTAGTGAGGCCTCTGAGGGCCTCCACACTGC
CTGGCAGAACATACCACTGAACTAGTATGTGCTAGAGGAGGGCACAAACATCCGCTCCTTCCCTAGGCCTGCTGGCTCTGGTTTTCTATG
CAGATGATTCATTGGATTGGGGGTGAGTGTTTTGTTTTTCTGGGGGCAGTGTGAGCTTTGAGGGTTGGAATATTGGGAGGCATTCCTTAG
TTTCCTCAACTAGCCTGGAAAGTTAGGAGTCTAGGGTAATTACCCCCAATGAGTCTAGCCTACTATTCACTGCTTTGTGTGCATTTTTTT
CTCCCTCTTTAAAAAACCCTTTAAAAGAAAAAAAAAAGTAGATAGTGCTAAATATTTTAGCTCATGAAACTTGGTTAGGATGGCTGGGGG
TACAAGTCCCCAAACTACCTCTTGTTACAGTAGCCAGGGAGTGGAATTTCGTCAACCGGTACTTTTAAGGTTAGGATGGGACGGGAAAAG
TGAAGCAGGATATTAGCTCCTTATACCTTCTCCCTTCCATTTCTGAGATCTCACATTCCATCTATCACAGGGTTTTCAAAGAGATGCTGA
GGGTAACAAGGAACTCACTTGGCAGTCAGAGCATCATGCTTTGAGGTTTGGGGTGCTCAGGCTGGGAGGGTAGAATGCCATTCCAGAGGA
CAAGCCACAAAAATGCCTTAATTTGAGCTCGTATTTACCCCTGCTGATAAGTGACTTGAGAGTTCCCGGTTTTTTCCTCTTGTCCTTCCC
TCCCTTCTGTCCTTCCATGTGTGGGGAAAGGGTGTTTTTGGTAGAGCTTGGTTTCCAAAGCGCCTGGCTTTCTCACTTCACATTCTCAAG
TGGCAGTTTCATTATTTAGAATGCAAGGTGGACATCTTTTGGATATCTTTTTCTATATATTTTCTAAAGCTTTACATATGAGAGGGTATA
GGGAGGTGTTTATAAAACACTTGAGAACTTTTTTCCTTAATATCAGAAAGCAAAAAAATAAAACCACAATTGAGATTTGCCTTTCAAACC
CTCAGGTTTGCCTCTAACCAGGTGTCCCTGGTCACCATCAGAGTACTGGAATACGGGAACCGAGGAGACCTTGGTCCTTTTGTTTTTGTT
CTGGACTCTTGGGAGTGGAAATGAGAATGAGTTTATTCCTACTGGAGCTTAGTTCCAATGCATTTGGCTCCAGAAAGACCCCAGTGCCTT
TTGACAATGGCCAGGGTTTTACCTACTTCCTGCCAGTCTTTCCCAAAGGAAACTCATTCCAAATACTTCTTTTTTCCCCTGGAGTCCGAG
AAGGAAAATGGAATTCTGGTTCATACTGTGGTCCCTTGTAACCTCAGGTCTTTAATGTGATCACTTTCAAATTTAAAAGATCCAGGTGGA
AATATTTTTACTATAGTAATAATTCTACAAAATACCTGAATTCTTAACACTGTTATATTTCAGTATAAGTGGTGGCTTTTTCTTTTCATG
TCTTTGATCTGGTTTTATTCCTGTAATTCAGCCACCTGATTTTGTGAGGGGGGGGAATAATATGTGGTTTTTGTACAAACATGTTTCTCA
GTGTGTTGTTATTTTGGAAAAAATGAGGGGAGGGAGTTTGGCAAGAATGGAGAAAATGAATGAAGAAGGCCTAATCTCTCTCTTTTTCAG
TGAATAAATGGAACACCATTTCTGGATTCTAGTCCCATTCTCTGCATTCATACACCAGTTTCTTCATATATCCTATGAAGAACCTAAACA
TTTGGCCCCACCTGGTCTTGGTTTGATCAGCAGTTAAAATTCTGTGACTCGGGCTTCCTTCCCGACTGCCCACCTTCATGATGTGTAAGG
AACATACATTTTGAGGGTACCTCACCCACTGTTCATTTGCATGGTCAAAGTGAAAATGAGTGGAAGTTCTCCAAAAATGATGGCCAACAT
CCTGGCACCTCCAGGTGTGAGAAATAGCTTTGCTTGGTGAATGGGATAATGTTTGTCAGGATGCAGTTTAGACAGTCCCAAGTTGGAGGC
AGGCCTTGAGGGCAGAAGATTCTGTGAACCTTGGGGGACAGCTTTTGGGTACTCACAGATATAAACCCTGTGCAGAAAAAAAGAAGTGAT
TGTTTTCAGGATGCTTATAAATCGAGTGAAGCAAAAGAAGAGGATTCTGTGTCTGCCATGAGATGAACGCCCTGCTCTTCACGAAGGTGT
GCCTCTAATAAAGAGAGCCAAAGCCAGCTGGGTCTCACCAGATTCCTATACTTTCTCAAGGATGTTGGGGGAGGTTAATCCTTTATCGAA
ACTAAAGACTGGTTTATGTCAGATACCAGGCCCAGGTTCCATGATGCCCGGGCAGCACATGCCAGGCCGCATGATTCCCACTGTTGCAGC
CAACATCCACCCCTCTGGGAGTGGCCCTACCCCTCCTGGCATGCCACCAATGCCAGGAAACATCTTAGGACCCCGGGTACCCCTGACAGC
ACCTAACGGCATGTATGATGCCTCATCAACAGCCCCCTCCCTACCCTCTGATGCACCACCAGATGCCACCACCTCATCCACCCCAGCCAG

>In-frame_ENST00000366721_ENST00000254480_BI051269_GUK1_chr1_228336090_-_SMARCC1_chr3_47651631_length(amino acids)=184AA_start in transcript=10_stop in transcript=564
MGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSRESRALVEGYHEEPEARRGERQREVMQRDIAAGDFIEHAEFSGNL
YGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESMMWSSLTTAWTR

--------------------------------------------------------------
>In-frame_ENST00000366718_ENST00000254480_BI051269_GUK1_chr1_228336090_-_SMARCC1_chr3_47651631_length(transcript)=4257nt_BP=969nt
CGCCTCGCCTGAGTTGTGTCCAAGGTGTGCGTGTGGCCAGGGGTCCATCCGCTTCCCTCTAGCCCAGCCCCTGAACACAGCTGCAGTGCA
CGGCCCCACTCCTCAGCTCTGCTCCCCATCCCAACTCGAAGACGCTGCCCTGGCCCTGTGTGTGCAGCTCATGTGGACTGGGAGGGCAGG
GCAGGTGCAGGTCTTGGGGCAAGAGCTGGAGCTGTCTTTTCCTTCCTGCACAGCCGCAGAGCAGGTGGATGGGGCTGCTTCCCTGCAAGG
GCCCAGGGCCAGGCCCCCTGGGGATTTATTCGTGGCTTAGAAGGGTGGGGCCAGAAGCAGGCGTAGTGGGGATTAGGGACTCAGCACCCC
CAGCTCTCAGTCCAGCAGACAGACCCACCCCAGGCTGACTACAGAGGCTGCACCTCAGCAAACAGGCATGTCGGGCCCCAGGCCTGTGGT
GCTGAGCGGGCCTTCGGGAGCTGGGAAGAGCACCCTGCTGAAGAGGCTGCTCCAGGAGCACAGCGGCATCTTTGGCTTCAGCGTGTCCCA
TACCACGAGGAACCCGAGGCCCGGCGAGGAGAACGGCAAAGATTACTACTTTGTAACCAGGGAGGTGATGCAGCGTGACATAGCAGCCGG
CGACTTCATCGAGCATGCCGAGTTCTCGGGGAACCTGTATGGCACGAGCAAGGTGGCGGTGCAGGCCGTGCAGGCCATGAACCGCATCTG
TGTGCTGGACGTGGACCTGCAGGGTGTGCGGAACATCAAGGCCACCGATCTGCGGCCCATCTACATCTCTGTGCAGCCGCCTTCACTGCA
CGTGCTGGAGCAGCGGCTGCGGCAGCGCAACACTGAAACCGAGGAGAGCCTGGTGAAGCGGCTGGCTGCTGCCCAGGCCGACATGGAGAG
CATGATGTGGTCATCATTAACGACAGCCTGGACCAGGCCTACGCAGAGCTGAAGGAGGCGCTCTCTGAGATCCCCCTCCACCACAGCAGC
AGCCACCGCCACCACCACCTGCAGATGGGGTCCCTCCGCCTCCTGCTCCTGGCCCGCCAGCCTCAGCTGCTCCTTAGCCTGGAAGATGCA
GGGAACCTCCACGCCCACCACCATGAGCTGGAGTGGGGATGACAAGACTTGTGTTCCTCAACTTTCTTGGGTTTCTTTCAGGATTTTTCT
TCTCACAGCTCCAAGCACGTGTCCCGTGCCTCCCCACTCCTCTTACCACCCCTCTCTCTGACACTTTTTGTGTTGGGTCCTCAGCCAACA
CTCAAGGGGAAACCTGTAGTGACAGTGTGCCCTGGTCATCCTTAAAATAACCTGCATCTCCCCTGTCCTGGTGTGGGAGTAAGCTGACAG
TTTCTCTGCAGGTCCTGTCAACTTTAGCATGCTATGTCTTTACCATTTTTGCTCTCTTGCAGTTTTTTGCTTTGTCTTATGCTTCTATGG
ATAATGCTATATAATCATTATCTTTTTATCTTTCTGTTATTATTGTTTTAAAGGAGAGCATCCTAAGTTAATAGGAACCAAAAAATAATG
ATGGGCAGAAGGGGGGGAATAGCCACAGGGGACAAACCTTAAGGCATTATAAGTGACCTTATTTCTGCTTTTCTGAGCTAAGAATGGTGC
TGATGGTAAAGTTTGAGACTTTTGCCACACACAAATTTGTGAAAATTAAACGAGATGTGGAAGGAGAACCTCAGTGATTTTATTCCCTAG
TGAGGCCTCTGAGGGCCTCCACACTGCCTGGCAGAACATACCACTGAACTAGTATGTGCTAGAGGAGGGCACAAACATCCGCTCCTTCCC
TAGGCCTGCTGGCTCTGGTTTTCTATGCAGATGATTCATTGGATTGGGGGTGAGTGTTTTGTTTTTCTGGGGGCAGTGTGAGCTTTGAGG
GTTGGAATATTGGGAGGCATTCCTTAGTTTCCTCAACTAGCCTGGAAAGTTAGGAGTCTAGGGTAATTACCCCCAATGAGTCTAGCCTAC
TATTCACTGCTTTGTGTGCATTTTTTTCTCCCTCTTTAAAAAACCCTTTAAAAGAAAAAAAAAAGTAGATAGTGCTAAATATTTTAGCTC
ATGAAACTTGGTTAGGATGGCTGGGGGTACAAGTCCCCAAACTACCTCTTGTTACAGTAGCCAGGGAGTGGAATTTCGTCAACCGGTACT
TTTAAGGTTAGGATGGGACGGGAAAAGTGAAGCAGGATATTAGCTCCTTATACCTTCTCCCTTCCATTTCTGAGATCTCACATTCCATCT
ATCACAGGGTTTTCAAAGAGATGCTGAGGGTAACAAGGAACTCACTTGGCAGTCAGAGCATCATGCTTTGAGGTTTGGGGTGCTCAGGCT
GGGAGGGTAGAATGCCATTCCAGAGGACAAGCCACAAAAATGCCTTAATTTGAGCTCGTATTTACCCCTGCTGATAAGTGACTTGAGAGT
TCCCGGTTTTTTCCTCTTGTCCTTCCCTCCCTTCTGTCCTTCCATGTGTGGGGAAAGGGTGTTTTTGGTAGAGCTTGGTTTCCAAAGCGC
CTGGCTTTCTCACTTCACATTCTCAAGTGGCAGTTTCATTATTTAGAATGCAAGGTGGACATCTTTTGGATATCTTTTTCTATATATTTT
CTAAAGCTTTACATATGAGAGGGTATAGGGAGGTGTTTATAAAACACTTGAGAACTTTTTTCCTTAATATCAGAAAGCAAAAAAATAAAA
CCACAATTGAGATTTGCCTTTCAAACCCTCAGGTTTGCCTCTAACCAGGTGTCCCTGGTCACCATCAGAGTACTGGAATACGGGAACCGA
GGAGACCTTGGTCCTTTTGTTTTTGTTCTGGACTCTTGGGAGTGGAAATGAGAATGAGTTTATTCCTACTGGAGCTTAGTTCCAATGCAT
TTGGCTCCAGAAAGACCCCAGTGCCTTTTGACAATGGCCAGGGTTTTACCTACTTCCTGCCAGTCTTTCCCAAAGGAAACTCATTCCAAA
TACTTCTTTTTTCCCCTGGAGTCCGAGAAGGAAAATGGAATTCTGGTTCATACTGTGGTCCCTTGTAACCTCAGGTCTTTAATGTGATCA
CTTTCAAATTTAAAAGATCCAGGTGGAAATATTTTTACTATAGTAATAATTCTACAAAATACCTGAATTCTTAACACTGTTATATTTCAG
TATAAGTGGTGGCTTTTTCTTTTCATGTCTTTGATCTGGTTTTATTCCTGTAATTCAGCCACCTGATTTTGTGAGGGGGGGGAATAATAT
GTGGTTTTTGTACAAACATGTTTCTCAGTGTGTTGTTATTTTGGAAAAAATGAGGGGAGGGAGTTTGGCAAGAATGGAGAAAATGAATGA
AGAAGGCCTAATCTCTCTCTTTTTCAGTGAATAAATGGAACACCATTTCTGGATTCTAGTCCCATTCTCTGCATTCATACACCAGTTTCT
TCATATATCCTATGAAGAACCTAAACATTTGGCCCCACCTGGTCTTGGTTTGATCAGCAGTTAAAATTCTGTGACTCGGGCTTCCTTCCC
GACTGCCCACCTTCATGATGTGTAAGGAACATACATTTTGAGGGTACCTCACCCACTGTTCATTTGCATGGTCAAAGTGAAAATGAGTGG
AAGTTCTCCAAAAATGATGGCCAACATCCTGGCACCTCCAGGTGTGAGAAATAGCTTTGCTTGGTGAATGGGATAATGTTTGTCAGGATG
CAGTTTAGACAGTCCCAAGTTGGAGGCAGGCCTTGAGGGCAGAAGATTCTGTGAACCTTGGGGGACAGCTTTTGGGTACTCACAGATATA
AACCCTGTGCAGAAAAAAAGAAGTGATTGTTTTCAGGATGCTTATAAATCGAGTGAAGCAAAAGAAGAGGATTCTGTGTCTGCCATGAGA
TGAACGCCCTGCTCTTCACGAAGGTGTGCCTCTAATAAAGAGAGCCAAAGCCAGCTGGGTCTCACCAGATTCCTATACTTTCTCAAGGAT
GTTGGGGGAGGTTAATCCTTTATCGAAACTAAAGACTGGTTTATGTCAGATACCAGGCCCAGGTTCCATGATGCCCGGGCAGCACATGCC
AGGCCGCATGATTCCCACTGTTGCAGCCAACATCCACCCCTCTGGGAGTGGCCCTACCCCTCCTGGCATGCCACCAATGCCAGGAAACAT
CTTAGGACCCCGGGTACCCCTGACAGCACCTAACGGCATGTATGATGCCTCATCAACAGCCCCCTCCCTACCCTCTGATGCACCACCAGA

>In-frame_ENST00000366718_ENST00000254480_BI051269_GUK1_chr1_228336090_-_SMARCC1_chr3_47651631_length(amino acids)=185AA_start in transcript=394_stop in transcript=951
MTTEAAPQQTGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGN
LYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESMMWSSLTTAWT

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>In-frame_ENST00000366716_ENST00000254480_BI051269_GUK1_chr1_228336090_-_SMARCC1_chr3_47651631_length(transcript)=3889nt_BP=601nt
CAGCAGATGGGGACTAGAGGCCGCACTGCTATCCACAGCCTCTCTTCTCACCCCCAGGCATGTCGGGCCCCAGGCCTGTGGTGCTGAGCG
GGCCTTCGGGAGCTGGGAAGAGCACCCTGCTGAAGAGGCTGCTCCAGGAGCACAGCGGCATCTTTGGCTTCAGCGTGTCCCATACCACGA
GGAACCCGAGGCCCGGCGAGGAGAACGGCAAAGATTACTACTTTGTAACCAGGGAGGTGATGCAGCGTGACATAGCAGCCGGCGACTTCA
TCGAGCATGCCGAGTTCTCGGGGAACCTGTATGGCACGAGCAAGGTGGCGGTGCAGGCCGTGCAGGCCATGAACCGCATCTGTGTGCTGG
ACGTGGACCTGCAGGGTGTGCGGAACATCAAGGCCACCGATCTGCGGCCCATCTACATCTCTGTGCAGCCGCCTTCACTGCACGTGCTGG
AGCAGCGGCTGCGGCAGCGCAACACTGAAACCGAGGAGAGCCTGGTGAAGCGGCTGGCTGCTGCCCAGGCCGACATGGAGAGCATGATGT
GGTCATCATTAACGACAGCCTGGACCAGGCCTACGCAGAGCTGAAGGAGGCGCTCTCTGAGATCCCCCTCCACCACAGCAGCAGCCACCG
CCACCACCACCTGCAGATGGGGTCCCTCCGCCTCCTGCTCCTGGCCCGCCAGCCTCAGCTGCTCCTTAGCCTGGAAGATGCAGGGAACCT
CCACGCCCACCACCATGAGCTGGAGTGGGGATGACAAGACTTGTGTTCCTCAACTTTCTTGGGTTTCTTTCAGGATTTTTCTTCTCACAG
CTCCAAGCACGTGTCCCGTGCCTCCCCACTCCTCTTACCACCCCTCTCTCTGACACTTTTTGTGTTGGGTCCTCAGCCAACACTCAAGGG
GAAACCTGTAGTGACAGTGTGCCCTGGTCATCCTTAAAATAACCTGCATCTCCCCTGTCCTGGTGTGGGAGTAAGCTGACAGTTTCTCTG
CAGGTCCTGTCAACTTTAGCATGCTATGTCTTTACCATTTTTGCTCTCTTGCAGTTTTTTGCTTTGTCTTATGCTTCTATGGATAATGCT
ATATAATCATTATCTTTTTATCTTTCTGTTATTATTGTTTTAAAGGAGAGCATCCTAAGTTAATAGGAACCAAAAAATAATGATGGGCAG
AAGGGGGGGAATAGCCACAGGGGACAAACCTTAAGGCATTATAAGTGACCTTATTTCTGCTTTTCTGAGCTAAGAATGGTGCTGATGGTA
AAGTTTGAGACTTTTGCCACACACAAATTTGTGAAAATTAAACGAGATGTGGAAGGAGAACCTCAGTGATTTTATTCCCTAGTGAGGCCT
CTGAGGGCCTCCACACTGCCTGGCAGAACATACCACTGAACTAGTATGTGCTAGAGGAGGGCACAAACATCCGCTCCTTCCCTAGGCCTG
CTGGCTCTGGTTTTCTATGCAGATGATTCATTGGATTGGGGGTGAGTGTTTTGTTTTTCTGGGGGCAGTGTGAGCTTTGAGGGTTGGAAT
ATTGGGAGGCATTCCTTAGTTTCCTCAACTAGCCTGGAAAGTTAGGAGTCTAGGGTAATTACCCCCAATGAGTCTAGCCTACTATTCACT
GCTTTGTGTGCATTTTTTTCTCCCTCTTTAAAAAACCCTTTAAAAGAAAAAAAAAAGTAGATAGTGCTAAATATTTTAGCTCATGAAACT
TGGTTAGGATGGCTGGGGGTACAAGTCCCCAAACTACCTCTTGTTACAGTAGCCAGGGAGTGGAATTTCGTCAACCGGTACTTTTAAGGT
TAGGATGGGACGGGAAAAGTGAAGCAGGATATTAGCTCCTTATACCTTCTCCCTTCCATTTCTGAGATCTCACATTCCATCTATCACAGG
GTTTTCAAAGAGATGCTGAGGGTAACAAGGAACTCACTTGGCAGTCAGAGCATCATGCTTTGAGGTTTGGGGTGCTCAGGCTGGGAGGGT
AGAATGCCATTCCAGAGGACAAGCCACAAAAATGCCTTAATTTGAGCTCGTATTTACCCCTGCTGATAAGTGACTTGAGAGTTCCCGGTT
TTTTCCTCTTGTCCTTCCCTCCCTTCTGTCCTTCCATGTGTGGGGAAAGGGTGTTTTTGGTAGAGCTTGGTTTCCAAAGCGCCTGGCTTT
CTCACTTCACATTCTCAAGTGGCAGTTTCATTATTTAGAATGCAAGGTGGACATCTTTTGGATATCTTTTTCTATATATTTTCTAAAGCT
TTACATATGAGAGGGTATAGGGAGGTGTTTATAAAACACTTGAGAACTTTTTTCCTTAATATCAGAAAGCAAAAAAATAAAACCACAATT
GAGATTTGCCTTTCAAACCCTCAGGTTTGCCTCTAACCAGGTGTCCCTGGTCACCATCAGAGTACTGGAATACGGGAACCGAGGAGACCT
TGGTCCTTTTGTTTTTGTTCTGGACTCTTGGGAGTGGAAATGAGAATGAGTTTATTCCTACTGGAGCTTAGTTCCAATGCATTTGGCTCC
AGAAAGACCCCAGTGCCTTTTGACAATGGCCAGGGTTTTACCTACTTCCTGCCAGTCTTTCCCAAAGGAAACTCATTCCAAATACTTCTT
TTTTCCCCTGGAGTCCGAGAAGGAAAATGGAATTCTGGTTCATACTGTGGTCCCTTGTAACCTCAGGTCTTTAATGTGATCACTTTCAAA
TTTAAAAGATCCAGGTGGAAATATTTTTACTATAGTAATAATTCTACAAAATACCTGAATTCTTAACACTGTTATATTTCAGTATAAGTG
GTGGCTTTTTCTTTTCATGTCTTTGATCTGGTTTTATTCCTGTAATTCAGCCACCTGATTTTGTGAGGGGGGGGAATAATATGTGGTTTT
TGTACAAACATGTTTCTCAGTGTGTTGTTATTTTGGAAAAAATGAGGGGAGGGAGTTTGGCAAGAATGGAGAAAATGAATGAAGAAGGCC
TAATCTCTCTCTTTTTCAGTGAATAAATGGAACACCATTTCTGGATTCTAGTCCCATTCTCTGCATTCATACACCAGTTTCTTCATATAT
CCTATGAAGAACCTAAACATTTGGCCCCACCTGGTCTTGGTTTGATCAGCAGTTAAAATTCTGTGACTCGGGCTTCCTTCCCGACTGCCC
ACCTTCATGATGTGTAAGGAACATACATTTTGAGGGTACCTCACCCACTGTTCATTTGCATGGTCAAAGTGAAAATGAGTGGAAGTTCTC
CAAAAATGATGGCCAACATCCTGGCACCTCCAGGTGTGAGAAATAGCTTTGCTTGGTGAATGGGATAATGTTTGTCAGGATGCAGTTTAG
ACAGTCCCAAGTTGGAGGCAGGCCTTGAGGGCAGAAGATTCTGTGAACCTTGGGGGACAGCTTTTGGGTACTCACAGATATAAACCCTGT
GCAGAAAAAAAGAAGTGATTGTTTTCAGGATGCTTATAAATCGAGTGAAGCAAAAGAAGAGGATTCTGTGTCTGCCATGAGATGAACGCC
CTGCTCTTCACGAAGGTGTGCCTCTAATAAAGAGAGCCAAAGCCAGCTGGGTCTCACCAGATTCCTATACTTTCTCAAGGATGTTGGGGG
AGGTTAATCCTTTATCGAAACTAAAGACTGGTTTATGTCAGATACCAGGCCCAGGTTCCATGATGCCCGGGCAGCACATGCCAGGCCGCA
TGATTCCCACTGTTGCAGCCAACATCCACCCCTCTGGGAGTGGCCCTACCCCTCCTGGCATGCCACCAATGCCAGGAAACATCTTAGGAC
CCCGGGTACCCCTGACAGCACCTAACGGCATGTATGATGCCTCATCAACAGCCCCCTCCCTACCCTCTGATGCACCACCAGATGCCACCA

>In-frame_ENST00000366716_ENST00000254480_BI051269_GUK1_chr1_228336090_-_SMARCC1_chr3_47651631_length(amino acids)=174AA_start in transcript=59_stop in transcript=583
MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQA

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Fusion Gene PPI Analysis for GUK1-SMARCC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GUK1-SMARCC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GUK1-SMARCC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSMARCC1C0001418Adenocarcinoma1CTD_human
TgeneSMARCC1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneSMARCC1C0024121Lung Neoplasms1CTD_human
TgeneSMARCC1C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneSMARCC1C0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneSMARCC1C0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneSMARCC1C0205643Carcinoma, Cribriform1CTD_human
TgeneSMARCC1C0205644Carcinoma, Granular Cell1CTD_human
TgeneSMARCC1C0205645Adenocarcinoma, Tubular1CTD_human
TgeneSMARCC1C0242379Malignant neoplasm of lung1CTD_human