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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:H3F3B-CCT5 (FusionGDB2 ID:35394)

Fusion Gene Summary for H3F3B-CCT5

check button Fusion gene summary
Fusion gene informationFusion gene name: H3F3B-CCT5
Fusion gene ID: 35394
HgeneTgene
Gene symbol

H3F3B

CCT5

Gene ID

3021

22948

Gene nameH3.3 histone Bchaperonin containing TCP1 subunit 5
SynonymsH3-3A|H3.3B|H3F3BCCT-epsilon|CCTE|HEL-S-69|PNAS-102|TCP-1-epsilon
Cytomap

17q25.1

5p15.2

Type of geneprotein-codingprotein-coding
Descriptionhistone H3.3H3 histone family member 3BH3 histone, family 3B (H3.3B)T-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69
Modification date2020031320200313
UniProtAcc.

P48643

Ensembl transtripts involved in fusion geneENST00000254810, ENST00000593254, 
ENST00000592643, ENST00000591890, 
ENST00000587560, ENST00000589599, 
ENST00000586607, 		ENST00000280326, 
ENST00000503026, ENST00000515390, 
ENST00000515676, ENST00000506600, 
Fusion gene scores* DoF score8 X 11 X 4=35258 X 14 X 17=13804
# samples 1061
** MAII scorelog2(10/352*10)=-1.81557542886257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(61/13804*10)=-4.50013332598527
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: H3F3B [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointH3F3B(73772517)-CCT5(10250033), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneH3F3B

GO:0006334

nucleosome assembly

21636898

HgeneH3F3B

GO:0006336

DNA replication-independent nucleosome assembly

14718166


check buttonFusion gene breakpoints across H3F3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CCT5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-A61C-01AH3F3Bchr17

73772517

-CCT5chr5

10250033

+


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Fusion Gene ORF analysis for H3F3B-CCT5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000254810ENST00000280326H3F3Bchr17

73772517

-CCT5chr5

10250033

+
5CDS-intronENST00000254810ENST00000503026H3F3Bchr17

73772517

-CCT5chr5

10250033

+
5CDS-intronENST00000254810ENST00000515390H3F3Bchr17

73772517

-CCT5chr5

10250033

+
5CDS-intronENST00000254810ENST00000515676H3F3Bchr17

73772517

-CCT5chr5

10250033

+
5CDS-intronENST00000254810ENST00000506600H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-3CDSENST00000593254ENST00000280326H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000593254ENST00000503026H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000593254ENST00000515390H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000593254ENST00000515676H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000593254ENST00000506600H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-3CDSENST00000592643ENST00000280326H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000592643ENST00000503026H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000592643ENST00000515390H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000592643ENST00000515676H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000592643ENST00000506600H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-3CDSENST00000591890ENST00000280326H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000591890ENST00000503026H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000591890ENST00000515390H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000591890ENST00000515676H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000591890ENST00000506600H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-3CDSENST00000587560ENST00000280326H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000587560ENST00000503026H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000587560ENST00000515390H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000587560ENST00000515676H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000587560ENST00000506600H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-3CDSENST00000589599ENST00000280326H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000589599ENST00000503026H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000589599ENST00000515390H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000589599ENST00000515676H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000589599ENST00000506600H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-3CDSENST00000586607ENST00000280326H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000586607ENST00000503026H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000586607ENST00000515390H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000586607ENST00000515676H3F3Bchr17

73772517

-CCT5chr5

10250033

+
intron-intronENST00000586607ENST00000506600H3F3Bchr17

73772517

-CCT5chr5

10250033

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000254810H3F3Bchr1773772517-ENST00000280326CCT5chr510250033+6380270530954750551

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000254810ENST00000280326H3F3Bchr1773772517-CCT5chr510250033+0.0004431270.99955684

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Fusion Genomic Features for H3F3B-CCT5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
H3F3Bchr1773772514-CCT5chr510250032+0.0111597370.9888403
H3F3Bchr1773772514-CCT5chr510250032+0.0111597370.9888403

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for H3F3B-CCT5


check button Go to

FGviewer for the breakpoints of chr17:73772517-chr5:10250033

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CCT5

P48643

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for H3F3B-CCT5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000254810_ENST00000280326_TCGA-HT-A61C-01A_H3F3B_chr17_73772517_-_CCT5_chr5_10250033_length(transcript)=6380nt_BP=2705nt
GAGCGCAGAGCGGTTTGGTCGTTCGTTGGGCGGTGCTGGTTTTTCGCTCGTCGACTGCGGCTCTTCCTCGGGCAGCGGAAGCGGCGCGGC
GGTCGGAGAAGTGGCCTAAAACTTCGGCGTTGGGTGAAAGAAAATGGCCCGAACCAAGCAGACTGCTCGTAAGTCCACCGGTGGGAAAGC
CCCCCGCAAACAGCTGGCCACGAAAGCCGCCAGGAAAAGCGCTCCCTCTACCGGCGGGGTGAAGAAGCCTCATCGCTACAGGCCCGGGAC
CGTGGCGCTTCGAGAGATTCGTCGTTATCAGAAGTCGACCGAGCTGCTCATCCGGAAGCTGCCCTTCCAGAGGTTGGTGAGGGAGATCGC
GCAGGATTTCAAAACCGACCTGAGGTTTCAGAGCGCAGCCATCGGTGCGCTGCAGGAGGCTAGCGAAGCGTACCTGGTGGGTCTGTTCGA
AGATACCAACCTGTGTGCCATCCACGCTAAGAGAGTCACCATCATGCCCAAAGACATCCAGTTGGCTCGCCGGATACGGGGAGAGAGAGC
TTAAGTGAAGGCAGTTTTTATGGCGTTTTGTAGTAAATTCTGTAAAATACTTTGGTTTAATTTGTGACTTTTTTTGTAAGAAATTGTTTA
TAATATGTTGCATTTGTACTTAAGTCATTCCATCTTTCACTCAGGATGAATGCGAAAAGTGACTGTTCACAGACCTCAGTGATGTGAGCA
CTGTTGCTCAGGAGTGACAAGTTGCTAATATGCAGAAGGGATGGGTGATACTTCTTGCTTCTCATGATGCATGTTTCTGTATGTTAATGA
CTTGTTGGGTAGCTATTAAGGTACTAGAGTTGATAAATGTGTACAGGGTCCTTTTGCAATAAAACTGGTTATGACTTGATCCAAGTGTTT
AACAATTGGGGCTGTTAAGTCTGACCATACATCACTGTGATAGAATGTGGGCTTTTTCAAGGGTGAAGATACAAGTCTTAACCACAGTGT
AACTTACAGTTTCCTTTAAAAAAAAAAAAAGTAAACCTGGCAGCTATAGAATACACTATGTGCATTTATAATAGCTATTTTATATATTGT
AGTATCAACATTTTTAAATTAAATGTTTTACATTCACAAGTGGTGGGGAGTCTTGTCATTAAGGTGTGTGTAATTTAGAGTCCAGTTGGT
TTTCTTCTGACTGCACTTGTTCTCATAGTAGTAAAATGCTATGCGCATTTATACCTTGCATAAGTCCTCATTCTACCACATGTTAACCCT
CTAGCTGATAATGCAAACACTAACTGGGGGATTTTATTTATAAGGGCTCTAGAAAAAACGAGTTATTCACACCAGCATCATCTTAACTAA
CATTCTGAACTAGTTAGTGCAGCTTTTCATTGTGTTGTGTGGTTGGTCTCATAACTAGGTTGAGTTTTTCTCCTCTGCTGAGGAAACAGT
ACCGAAGTTCTTTTTCTTGTGGCATTTGTATTATAAAAACTTGGTGTGGGGGAGGAGCACAAAACTCCAGCCCACTGAACCTCTGCCAAT
TAAGATGGTGTTGGGTTAGGTTACATCTGGTTACTGTCCTGGGAAAATCATTTTTATAGAGATGGCCTTCCAAGTGGTTTTAAAATTTAC
TGAAGTTTTTAGGTCAATTATGTATGTTGACTAAATTTACAAATAAACTTGTTTATCCAACTAAGTGTCCAAAACCTAAATTGAATGTAC
TAAGTTTTCACATGTCCCATTATCTAGGTCCTTGTATACTAATGTTTTGAACTTAGATCATTTCAGGTGTTGTTTGGTGGATAAAGGAAC
CTTTTATTTATAAAGATACTGTAGAAAGCATGTGAACAGCTCTCTGCTTGATTAAGATGCCATAATAGTGCTGTATTTGCAGTGTGGGCT
AAGACAAAGTATATTAATAAGCTTTTCAGCCCCCCCACTCCCGTTCCGTAGTGTAGAAGCCCACAGGTGTAGAACTCAGTCTTAAACTTC
AGTATGAAACCAGTTTCCTTGTGCGATGATGGCCACTAAAGCATAGTACGTGGATGTCAGTGAGACAGCATGAGAGCCAGCAGTCATCAA
AGCGTTCCACGTTTGAAGTTAGCAACTGCTTAAAGTTATACCCCATTAAAATTGCTTTCTCAAAAGTTTGGGTTAGTTTCAAATGTGATA
TTTTGGAGGGAAGGTAAAGTAGGTATCTTTCAGGTCGTGATAATGAGCTCCTATGAAAGGATGCAATATAATGACCCGCTTTTCTAGAAA
GTTCATAATCAGCTCTGGAACAAGCACACTTGATTCCTCACTGTGCTTCAGAATGAGATTAAGATCAGATGTTGGAACGTGCTATGCTGT
AGCGTGTCTGGAAACAAAGTACACAAACCTGGCTACGGTGATGAGTTAGCTTCTGCTTACTACCTGTGACAACCCAAGTGGGTGACACTA
GTGAACCTTCTCCAGTCTGCAGGCTGGCATAGAAGGCTCTTAGATTATATTGGGCAGCTTGCAATCTGCCGAAGCAGTGACTTGCATTTC
CACACTTGGCTTGAGCACTCAACCCAGAAGGCGAAGATAGCTTTTGGTTGTAGGCGGCTTCCTGTATGGGATATCCCTCGGTAAGGGTAA
AGGAGCAGAGGCAAAGGAGAAAAGCAGAAGTTGCAGCTGATGCAGGTATCCTATGCCCTTGATGGATGAGACTAAAATAAAATTTTTGAA
GTTAAAAAAAAAAAAAAAACCGGAAATGGGTCCTACCATCTTCTCGGAGCCGGAGTGCGAAGAAATAAAGAAATAGTGCTTTAAGTCAAT
GAATTCCTCCTTGGGACCCACTATCGAGAAACTATCAGTGGTAACGTTTTAAAAAATGACAAATTCAATCTGCTCTTGACTTGTGTGTCC
TAAGATTTCCACTAAGTGTCTTCAAACCTCCCCCTCCCCGGCTTCCTGGATAATAGAAGTTCCCGAAGGCCGCCGATTCCAGAAGATACT
GTCTGGCGTGAAATTAGTCTCAGTAGAAACATAAGTCCCGCGCGTCTTGTGCTGCGCGTGCGCAAGCTTTTGGGCCCTCCCGAGAAAGGG
AAGTGCATTCTCGCTTCCGTAGCGGTCTCCGCCGGTTGGGGGGAAGTAATTCCGGTTGTTGCACCATGGCGTCCATGGGGACCCTCGCCT
TCGATGAATATGGGCGCCCTTTCCTCATCATCAAGGATCAGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCCTCAAGTCTCATATAA
TGGCAGCAAAGGCTGTAGCAAATACAATGAGAACATCACTTGGACCAAATGGGCTTGATAAGATGATGGTGGATAAGGATGGAGATGTGA
CTGTAACTAATGATGGGGCCACCATCTTAAGCATGATGGATGTTGATCATCAGATTGCCAAGCTGATGGTGGAACTGTCCAAGTCTCAGG
ATGATGAAATTGGAGATGGAACCACAGGAGTGGTTGTCCTGGCTGGTGCCTTGTTAGAAGAAGCGGAGCAATTGCTAGACCGAGGCATTC
ACCCAATCAGAATAGCCGATGGCTATGAGCAGGCTGCTCGTGTTGCTATTGAACACCTGGACAAGATCAGCGATAGCGTCCTTGTTGACA
TAAAGGACACCGAACCCCTGATTCAGACAGCAAAAACCACGCTGGGCTCCAAAGTGGTCAACAGTTGTCACCGACAGATGGCTGAGATTG
CTGTGAATGCCGTCCTCACTGTAGCAGATATGGAGCGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCAAAGTGGGCGGCAGGC
TGGAGGACACTAAACTGATTAAGGGCGTGATTGTGGACAAGGATTTCAGTCACCCACAGATGCCAAAAAAAGTGGAAGATGCGAAGATTG
CAATTCTCACATGTCCATTTGAACCACCCAAACCAAAAACAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATTATAAAGCCCTTCAGA
AATACGAAAAGGAGAAATTTGAAGAGATGATTCAACAAATTAAAGAGACTGGTGCTAACCTAGCAATTTGTCAGTGGGGCTTTGATGATG
AAGCAAATCACTTACTTCTTCAGAACAACTTGCCTGCGGTTCGCTGGGTAGGAGGACCTGAAATTGAGCTGATTGCCATCGCAACAGGAG
GGCGGATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAGGAGATCTCATTTGGGACAACTAAGG
ATAAAATGCTGGTCATCGAGCAGTGTAAGAACTCCAGAGCTGTAACCATTTTTATTAGAGGAGGAAATAAGATGATCATTGAGGAGGCGA
AACGATCCCTTCACGATGCTTTGTGTGTCATCCGGAACCTCATCCGCGATAATCGTGTGGTGTATGGAGGAGGGGCTGCTGAGATATCCT
GTGCCCTGGCAGTTAGCCAAGAGGCGGATAAGTGCCCCACCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACGCACTGGAGGTCATCC
CCATGGCCCTCTCTGAAAACAGTGGCATGAATCCCATCCAGACTATGACCGAAGTCCGAGCCAGACAGGTGAAGGAGATGAACCCTGCTC
TTGGCATCGACTGTTTGCACAAGGGGACAAATGATATGAAGCAACAGCATGTCATAGAAACCTTGATTGGCAAAAAGCAACAGATATCTC
TTGCAACACAAATGGTTAGAATGATTTTGAAGATTGATGACATTCGTAAGCCTGGAGAATCTGAAGAATGAAGACATTGAGAAAACTATG
TAGCAAGATCCACTTCTGTGATTAAGTAAATGGATGTCTCGTGATGCATCTACAGTTATTTATTGTTACATCCTTTTCCAGACACTGTAG
ATGCTATAATAAAAATAGCTGTTTGGTAACCATAGTTTCACTTGTTCAAAGCTGTGTAATCGTGGGGGTACCATCTCAACTGCTTTTGTA
TTCATTGTATTAAAAGAATCTGTTTAAACAACCTTTATCTTCTCTTCGGGTTTAAGAAACGTTTATTGTAACAGTAATTAAATGCTGCCT
TAATTGAAGGGGTTTGGGTGGATTTTTTTTTCTCAAAATAAGCTGTAGGGACTATTTTAACAGCTTAAACAGGAGCTCTCAAGATGCACT
TTCATATTGAGAGGAATATGGGCTTGATCCTCTTCCTATCTAAATGGGTGGGCCATTTGATTGTAGAGGGTCCACCACAGAATTATGGGA
TGCCTTAAGTGCTGTTACTAGGTTGCTCACAGCCTAACCTGGCGTGTTGTTTAGGGCTGATGGAGACCCATGTGAGCCTTTGCTTTCCTC
TGGCCCCGGCCCCACCCTGAACACAGCTCATACACAGAATCAGGACCAGCATGTGCAGAGCTGGCCACCAGCACAGGCTTAGGGCAGTTC
AGAACCCACTTGTTTCCCTATCAGAGGGACACAGTGAAGTGGAGGTTAAAGTAAATTACAGGAAATAAGGGAGAAATCTTGCAGTTACCA
TGTTCAGATAGAGTGACTGAAATTAATTGTACTTACTAAAGTATTAACTAGCTAACAGTGATGGGCCAAGACGCTCCGAGAACTCTACCG
GGATTGTCTGTTCTGACAACCCAGTGAGGCAGATACACTTTCTTACTGCTCACATCTTACAGGTGAGTACTCATAATTGGCCAGCATCTC
ACCACCAGCAAGTAGTAGGGCCAGGTCAATCCCAGGCAGTCTGACCCCAGAGTGGCCCAGCTCATCCCCTACTCTGTTATTTGCTTGTTA
ATGATTCTCTAGATTTTCTAAAATAATGTTTCTTAGCATTGTGATGATAAAGCTCATGATGAACTTTATCACTAGTTATGCCACCTTAAC
TAGTCAGATTTCCTAGAATTAGGAAATGGTGACTCTTGTCTAAATTTGGTTAAGTGATGAATTTGGGTTACCGTCTCATGTGAACCTGGA
GATTCACCAGTCTTAACTTTTGGGTCATTGTGTTTTCTCTACATTCATGCATTGGATGTTTTGCTAAATAACTCCTGTGGATTTAGGAAT
GTGTGCTAATAGCAATCTTCCTAATTTTCATGTTTATATGGAACTATGCAGTTGAGTATTGAAAGCTTTAAACTGAGTTTATTTACAAGG
ACTGAGTCTAGCCTACAGAGAACATACAGCAGCCTTCTTTGGACCACAGTCTTATCCGAGGGGTCTGTGGTTGTATCAGAAGAGCCACTA
AACCAATCCCCCTTTCCAAAATTGAACCTCACAGACGTTCCTGTTTTTTGTGATTGAGAAACTGGTCAATGAACAGGAAGACTTAGAGAT

>In-frame_ENST00000254810_ENST00000280326_TCGA-HT-A61C-01A_H3F3B_chr17_73772517_-_CCT5_chr5_10250033_length(amino acids)=551AA_start in transcript=3095_stop in transcript=4750
MGGSNSGCCTMASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSM
MDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAK
TTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKP
KTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTA
EKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKC
PTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for H3F3B-CCT5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for H3F3B-CCT5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for H3F3B-CCT5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCCT5C1850395Neuropathy, Hereditary Sensory, with Spastic Paraplegia, Autosomal Recessive3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneCCT5C0006142Malignant neoplasm of breast1CTD_human
TgeneCCT5C0019193Hepatitis, Toxic1CTD_human
TgeneCCT5C0019693HIV Infections1CTD_human
TgeneCCT5C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneCCT5C0678222Breast Carcinoma1CTD_human
TgeneCCT5C0860207Drug-Induced Liver Disease1CTD_human
TgeneCCT5C1257931Mammary Neoplasms, Human1CTD_human
TgeneCCT5C1262760Hepatitis, Drug-Induced1CTD_human
TgeneCCT5C1458155Mammary Neoplasms1CTD_human
TgeneCCT5C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneCCT5C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneCCT5C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneCCT5C4505456HIV Coinfection1CTD_human
TgeneCCT5C4704874Mammary Carcinoma, Human1CTD_human