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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:HABP2-UQCRC2 (FusionGDB2 ID:35415) |
Fusion Gene Summary for HABP2-UQCRC2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: HABP2-UQCRC2 | Fusion gene ID: 35415 | Hgene | Tgene | Gene symbol | HABP2 | UQCRC2 | Gene ID | 3026 | 7385 |
Gene name | hyaluronan binding protein 2 | ubiquinol-cytochrome c reductase core protein 2 | |
Synonyms | FSAP|HABP|HGFAL|NMTC5|PHBP | MC3DN5|QCR2|UQCR2 | |
Cytomap | 10q25.3 | 16p12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | hyaluronan-binding protein 2factor VII activating proteinfactor VII-activating proteasefactor seven-activating proteasehepatocyte growth factor activator-like proteinhyaluronic acid binding protein 2plasma hyaluronan binding protein | cytochrome b-c1 complex subunit 2, mitochondrialcomplex III subunit 2cytochrome bc-1 complex core protein IIubiquinol-cytochrome c reductase core protein IIubiquinol-cytochrome-c reductase complex core protein 2 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q14520 | . | |
Ensembl transtripts involved in fusion gene | ENST00000542051, ENST00000351270, ENST00000537906, ENST00000541666, ENST00000460714, | ENST00000268379, ENST00000561553, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 9 X 11 X 7=693 |
# samples | 3 | 12 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/693*10)=-2.5298209465287 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HABP2 [Title/Abstract] AND UQCRC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | HABP2(115312949)-UQCRC2(21969856), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | HABP2 | GO:0006508 | proteolysis | 11217080 |
Fusion gene breakpoints across HABP2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across UQCRC2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-BR-8080-01A | HABP2 | chr10 | 115312949 | + | UQCRC2 | chr16 | 21969856 | + |
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Fusion Gene ORF analysis for HABP2-UQCRC2 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000542051 | ENST00000268379 | HABP2 | chr10 | 115312949 | + | UQCRC2 | chr16 | 21969856 | + |
intron-3CDS | ENST00000542051 | ENST00000561553 | HABP2 | chr10 | 115312949 | + | UQCRC2 | chr16 | 21969856 | + |
In-frame | ENST00000351270 | ENST00000268379 | HABP2 | chr10 | 115312949 | + | UQCRC2 | chr16 | 21969856 | + |
In-frame | ENST00000351270 | ENST00000561553 | HABP2 | chr10 | 115312949 | + | UQCRC2 | chr16 | 21969856 | + |
5UTR-3CDS | ENST00000537906 | ENST00000268379 | HABP2 | chr10 | 115312949 | + | UQCRC2 | chr16 | 21969856 | + |
5UTR-3CDS | ENST00000537906 | ENST00000561553 | HABP2 | chr10 | 115312949 | + | UQCRC2 | chr16 | 21969856 | + |
In-frame | ENST00000541666 | ENST00000268379 | HABP2 | chr10 | 115312949 | + | UQCRC2 | chr16 | 21969856 | + |
In-frame | ENST00000541666 | ENST00000561553 | HABP2 | chr10 | 115312949 | + | UQCRC2 | chr16 | 21969856 | + |
intron-3CDS | ENST00000460714 | ENST00000268379 | HABP2 | chr10 | 115312949 | + | UQCRC2 | chr16 | 21969856 | + |
intron-3CDS | ENST00000460714 | ENST00000561553 | HABP2 | chr10 | 115312949 | + | UQCRC2 | chr16 | 21969856 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000351270 | HABP2 | chr10 | 115312949 | + | ENST00000268379 | UQCRC2 | chr16 | 21969856 | + | 1749 | 165 | 96 | 1259 | 387 |
ENST00000351270 | HABP2 | chr10 | 115312949 | + | ENST00000561553 | UQCRC2 | chr16 | 21969856 | + | 1260 | 165 | 96 | 1136 | 346 |
ENST00000541666 | HABP2 | chr10 | 115312949 | + | ENST00000268379 | UQCRC2 | chr16 | 21969856 | + | 1703 | 119 | 50 | 1213 | 387 |
ENST00000541666 | HABP2 | chr10 | 115312949 | + | ENST00000561553 | UQCRC2 | chr16 | 21969856 | + | 1214 | 119 | 50 | 1090 | 346 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000351270 | ENST00000268379 | HABP2 | chr10 | 115312949 | + | UQCRC2 | chr16 | 21969856 | + | 0.000559707 | 0.99944025 |
ENST00000351270 | ENST00000561553 | HABP2 | chr10 | 115312949 | + | UQCRC2 | chr16 | 21969856 | + | 0.000806173 | 0.99919385 |
ENST00000541666 | ENST00000268379 | HABP2 | chr10 | 115312949 | + | UQCRC2 | chr16 | 21969856 | + | 0.000540194 | 0.9994598 |
ENST00000541666 | ENST00000561553 | HABP2 | chr10 | 115312949 | + | UQCRC2 | chr16 | 21969856 | + | 0.000753002 | 0.9992471 |
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Fusion Genomic Features for HABP2-UQCRC2 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
HABP2 | chr10 | 115312949 | + | UQCRC2 | chr16 | 21969855 | + | 0.011888543 | 0.9881115 |
HABP2 | chr10 | 115312949 | + | UQCRC2 | chr16 | 21969855 | + | 0.011888543 | 0.9881115 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for HABP2-UQCRC2 |
Go to FGviewer for the breakpoints of chr10:115312949-chr16:21969856 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
HABP2 | . |
FUNCTION: Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (PubMed:8827452, PubMed:10754382, PubMed:11217080). May function as a tumor suppressor negatively regulating cell proliferation and cell migration (PubMed:26222560). {ECO:0000269|PubMed:10754382, ECO:0000269|PubMed:11217080, ECO:0000269|PubMed:26222560, ECO:0000269|PubMed:8827452}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | HABP2 | chr10:115312949 | chr16:21969856 | ENST00000351270 | + | 1 | 13 | 111_148 | 23.0 | 561.0 | Domain | EGF-like 2 |
Hgene | HABP2 | chr10:115312949 | chr16:21969856 | ENST00000351270 | + | 1 | 13 | 150_188 | 23.0 | 561.0 | Domain | EGF-like 3 |
Hgene | HABP2 | chr10:115312949 | chr16:21969856 | ENST00000351270 | + | 1 | 13 | 193_276 | 23.0 | 561.0 | Domain | Kringle |
Hgene | HABP2 | chr10:115312949 | chr16:21969856 | ENST00000351270 | + | 1 | 13 | 314_555 | 23.0 | 561.0 | Domain | Peptidase S1 |
Hgene | HABP2 | chr10:115312949 | chr16:21969856 | ENST00000351270 | + | 1 | 13 | 73_109 | 23.0 | 561.0 | Domain | EGF-like 1 |
Hgene | HABP2 | chr10:115312949 | chr16:21969856 | ENST00000542051 | + | 1 | 13 | 111_148 | 0 | 535.0 | Domain | EGF-like 2 |
Hgene | HABP2 | chr10:115312949 | chr16:21969856 | ENST00000542051 | + | 1 | 13 | 150_188 | 0 | 535.0 | Domain | EGF-like 3 |
Hgene | HABP2 | chr10:115312949 | chr16:21969856 | ENST00000542051 | + | 1 | 13 | 193_276 | 0 | 535.0 | Domain | Kringle |
Hgene | HABP2 | chr10:115312949 | chr16:21969856 | ENST00000542051 | + | 1 | 13 | 314_555 | 0 | 535.0 | Domain | Peptidase S1 |
Hgene | HABP2 | chr10:115312949 | chr16:21969856 | ENST00000542051 | + | 1 | 13 | 73_109 | 0 | 535.0 | Domain | EGF-like 1 |
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Fusion Gene Sequence for HABP2-UQCRC2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000351270_ENST00000268379_TCGA-BR-8080-01A_HABP2_chr10_115312949_+_UQCRC2_chr16_21969856_length(transcript)=1749nt_BP=165nt CCTGAATCCTTGGAGACTGACATTTTTCCCCCCTAAAGGCATAGACAACAAAAGAAATTTTATTGAGAGGAAAACACAAGTCCTTAAACT GCAAAGATGTTTGCCAGGATGTCTGATCTCCATGTTCTGCTGTTAATGGCTCTGGTGGGAAAGACAGCCTGTGGGACGACAAAAGGAGCT TCATCTTTCAAGATAACCCGTGGAATTGAAGCAGTTGGTGGCAAATTAAGTGTGACCGCAACAAGGGAAAACATGGCTTATACTGTGGAA TGCCTGCGGGGTGATGTTGATATTCTAATGGAGTTCCTGCTCAATGTCACCACAGCACCAGAATTTCGTCGTTGGGAAGTAGCTGACCTT CAGCCTCAGCTAAAGATTGACAAAGCTGTGGCCTTTCAGAATCCGCAGACTCATGTCATTGAAAATTTGCATGCAGCAGCTTACCGGAAT GCCTTGGCTAATCCCTTGTATTGTCCTGACTATAGGATTGGAAAAGTGACATCAGAGGAGTTACATTACTTCGTTCAGAACCATTTCACA AGTGCAAGAATGGCTTTGATTGGACTTGGTGTGAGTCATCCTGTTCTAAAGCAAGTTGCTGAACAGTTTCTCAACATGAGGGGTGGGCTT GGTTTATCTGGTGCAAAGGCCAACTACCGTGGAGGTGAAATCCGAGAACAGAATGGAGACAGTCTTGTCCATGCTGCTTTTGTAGCAGAA AGTGCTGTCGCGGGAAGTGCAGAGGCAAATGCATTTAGTGTTCTTCAGCATGTCCTCGGTGCTGGGCCACATGTCAAGAGGGGCAGCAAC ACCACCAGCCATCTGCACCAGGCTGTTGCCAAGGCAACTCAGCAGCCATTTGATGTTTCTGCATTTAATGCCAGTTACTCAGATTCTGGA CTCTTTGGGATTTATACTATCTCCCAGGCCACAGCTGCTGGAGATGTTATCAAGGCTGCCTATAATCAAGTAAAAACAATAGCTCAAGGA AACCTTTCCAACACAGATGTCCAAGCTGCCAAGAACAAGCTGAAAGCTGGATACCTAATGTCAGTGGAGTCTTCTGAGTGTTTCCTGGAA GAAGTCGGGTCCCAGGCTCTAGTTGCTGGTTCTTACATGCCACCATCCACAGTCCTTCAGCAGATTGATTCAGTGGCTAATGCTGATATC ATAAATGCGGCAAAGAAGTTTGTTTCTGGCCAGAAGTCAATGGCAGCAAGTGGAAATTTGGGACATACACCTTTTGTTGATGAGTTGTAA TACTGATGCACACATTACAGGAGAGAGCTGAACGTTCTCTCAGCCCAGAGCAGCAAACACATGAAAGTCAGAAGTCTCTAATATATCATT TGTCTTTTTTCCAGTGAGGTAAAATAAGGCATAAATGCAGGTAATTATTCCCAGCTGACCTAAAGTCAATAAAACATTCTGTTTAAGTGT TTTTCTTACGTTTTTCTCAATGAGTTAATCAACAAGTATTTATTATGTGCTGATATCTTTGTTTTAGATGCTTTAAAGGAGACAGGAATA TAATTATTGAGTATAGAAGCATCAGAAACTATTAAAATTAAGGCTAAGTGGCTATCGGGGTAAATAGTGCCAGATTACTATTGGTGGCGT TTAAGATGAAAGCAAGTTCAAAATTTGTCATTTTGGGTGTCAACAGCTAAATGGTCTGGTTTTTACCCCTGTTTTGCCTTTTTTGCAATA >In-frame_ENST00000351270_ENST00000268379_TCGA-BR-8080-01A_HABP2_chr10_115312949_+_UQCRC2_chr16_21969856_length(amino acids)=387AA_start in transcript=96_stop in transcript=1259 MFARMSDLHVLLLMALVGKTACGTTKGASSFKITRGIEAVGGKLSVTATRENMAYTVECLRGDVDILMEFLLNVTTAPEFRRWEVADLQP QLKIDKAVAFQNPQTHVIENLHAAAYRNALANPLYCPDYRIGKVTSEELHYFVQNHFTSARMALIGLGVSHPVLKQVAEQFLNMRGGLGL SGAKANYRGGEIREQNGDSLVHAAFVAESAVAGSAEANAFSVLQHVLGAGPHVKRGSNTTSHLHQAVAKATQQPFDVSAFNASYSDSGLF GIYTISQATAAGDVIKAAYNQVKTIAQGNLSNTDVQAAKNKLKAGYLMSVESSECFLEEVGSQALVAGSYMPPSTVLQQIDSVANADIIN -------------------------------------------------------------- >In-frame_ENST00000351270_ENST00000561553_TCGA-BR-8080-01A_HABP2_chr10_115312949_+_UQCRC2_chr16_21969856_length(transcript)=1260nt_BP=165nt CCTGAATCCTTGGAGACTGACATTTTTCCCCCCTAAAGGCATAGACAACAAAAGAAATTTTATTGAGAGGAAAACACAAGTCCTTAAACT GCAAAGATGTTTGCCAGGATGTCTGATCTCCATGTTCTGCTGTTAATGGCTCTGGTGGGAAAGACAGCCTGTGGGACGACAAAAGGAGCT TCATCTTTCAAGATAACCCGTGGAATTGAAGCAGTTGGTGGCAAATTAAGTGTGACCGCAACAAGGGAAAACATGGCTTATACTGTGGAA TGCCTGCGGGGTGATGTTGATATTCTAATGGAGTTCCTGCTCAATGTCACCACAGCACCAGAATTTCGTCGTTGGGAAGTAGCTGACCTT CAGCCTCAGCTAAAGATTGACAAAGCTGTGGCCTTTCAGAATCCGCAGACTCATGTCATTGAAAATTTGCATGCAGCAGCTTACCGGAAT GCCTTGGCTAATCCCTTGTATTGTCCTGACTATAGGATTGGAAAAGTGACATCAGAGGAGTTACATTACTTCGTTCAGAACCATTTCACA AGTGCAAGAATGGCTTTGATTGGACTTGGTGTGAGTCATCCTGTTCTAAAGCAAGTTGCTGAACAGTTTCTCAACATGAGGGGTGGGCTT GGTTTATCTGGTGCAAAGGCCAACTACCGTGGAGGTGAAATCCGAGAACAGAATGGAGACAGTCTTGTCCATGCTGCTTTTGTAGCAGAA AGTGCTGTCGCGGGAAGTGCAGAGGCAAATGCATTTAGTGTTCTTCAGCATGTCCTCGGTGCTGGGCCACATGTCAAGAGGGGCAGCAAC ACCACCAGCCATCTGCACCAGGCTGTTGCCAAGGCAACTCAGCAGCCATTTGATGTTTCTGCATTTAATGCCAGTTACTCAGATTCTGGA CTCTTTGGGATTTATACTATCTCCCAGGCCACAGCTGCTGGAGATGTTATCAAGGCTGCCTATAATCAAGTAAAAACAATAGCTCAAGGA AACCTTTCCAACACAGATGTCCAAGCTGCCAAGCGGCAAAGAAGTTTGTTTCTGGCCAGAAGTCAATGGCAGCAAGTGGAAATTTGGGAC ATACACCTTTTGTTGATGAGTTGTAATACTGATGCACACATTACAGGAGAGAGCTGAACGTTCTCTCAGCCCAGAGCAGCAAACACATGA AAGTCAGAAGTCTCTAATATATCATTTGTCTTTTTTCCAGTGAGGTAAAATAAGGCATAAATGCAGGTAATTATTCCCAGCTGACCTAAA >In-frame_ENST00000351270_ENST00000561553_TCGA-BR-8080-01A_HABP2_chr10_115312949_+_UQCRC2_chr16_21969856_length(amino acids)=346AA_start in transcript=96_stop in transcript=1136 MFARMSDLHVLLLMALVGKTACGTTKGASSFKITRGIEAVGGKLSVTATRENMAYTVECLRGDVDILMEFLLNVTTAPEFRRWEVADLQP QLKIDKAVAFQNPQTHVIENLHAAAYRNALANPLYCPDYRIGKVTSEELHYFVQNHFTSARMALIGLGVSHPVLKQVAEQFLNMRGGLGL SGAKANYRGGEIREQNGDSLVHAAFVAESAVAGSAEANAFSVLQHVLGAGPHVKRGSNTTSHLHQAVAKATQQPFDVSAFNASYSDSGLF -------------------------------------------------------------- >In-frame_ENST00000541666_ENST00000268379_TCGA-BR-8080-01A_HABP2_chr10_115312949_+_UQCRC2_chr16_21969856_length(transcript)=1703nt_BP=119nt AACAAAAGAAATTTTATTGAGAGGAAAACACAAGTCCTTAAACTGCAAAGATGTTTGCCAGGATGTCTGATCTCCATGTTCTGCTGTTAA TGGCTCTGGTGGGAAAGACAGCCTGTGGGACGACAAAAGGAGCTTCATCTTTCAAGATAACCCGTGGAATTGAAGCAGTTGGTGGCAAAT TAAGTGTGACCGCAACAAGGGAAAACATGGCTTATACTGTGGAATGCCTGCGGGGTGATGTTGATATTCTAATGGAGTTCCTGCTCAATG TCACCACAGCACCAGAATTTCGTCGTTGGGAAGTAGCTGACCTTCAGCCTCAGCTAAAGATTGACAAAGCTGTGGCCTTTCAGAATCCGC AGACTCATGTCATTGAAAATTTGCATGCAGCAGCTTACCGGAATGCCTTGGCTAATCCCTTGTATTGTCCTGACTATAGGATTGGAAAAG TGACATCAGAGGAGTTACATTACTTCGTTCAGAACCATTTCACAAGTGCAAGAATGGCTTTGATTGGACTTGGTGTGAGTCATCCTGTTC TAAAGCAAGTTGCTGAACAGTTTCTCAACATGAGGGGTGGGCTTGGTTTATCTGGTGCAAAGGCCAACTACCGTGGAGGTGAAATCCGAG AACAGAATGGAGACAGTCTTGTCCATGCTGCTTTTGTAGCAGAAAGTGCTGTCGCGGGAAGTGCAGAGGCAAATGCATTTAGTGTTCTTC AGCATGTCCTCGGTGCTGGGCCACATGTCAAGAGGGGCAGCAACACCACCAGCCATCTGCACCAGGCTGTTGCCAAGGCAACTCAGCAGC CATTTGATGTTTCTGCATTTAATGCCAGTTACTCAGATTCTGGACTCTTTGGGATTTATACTATCTCCCAGGCCACAGCTGCTGGAGATG TTATCAAGGCTGCCTATAATCAAGTAAAAACAATAGCTCAAGGAAACCTTTCCAACACAGATGTCCAAGCTGCCAAGAACAAGCTGAAAG CTGGATACCTAATGTCAGTGGAGTCTTCTGAGTGTTTCCTGGAAGAAGTCGGGTCCCAGGCTCTAGTTGCTGGTTCTTACATGCCACCAT CCACAGTCCTTCAGCAGATTGATTCAGTGGCTAATGCTGATATCATAAATGCGGCAAAGAAGTTTGTTTCTGGCCAGAAGTCAATGGCAG CAAGTGGAAATTTGGGACATACACCTTTTGTTGATGAGTTGTAATACTGATGCACACATTACAGGAGAGAGCTGAACGTTCTCTCAGCCC AGAGCAGCAAACACATGAAAGTCAGAAGTCTCTAATATATCATTTGTCTTTTTTCCAGTGAGGTAAAATAAGGCATAAATGCAGGTAATT ATTCCCAGCTGACCTAAAGTCAATAAAACATTCTGTTTAAGTGTTTTTCTTACGTTTTTCTCAATGAGTTAATCAACAAGTATTTATTAT GTGCTGATATCTTTGTTTTAGATGCTTTAAAGGAGACAGGAATATAATTATTGAGTATAGAAGCATCAGAAACTATTAAAATTAAGGCTA AGTGGCTATCGGGGTAAATAGTGCCAGATTACTATTGGTGGCGTTTAAGATGAAAGCAAGTTCAAAATTTGTCATTTTGGGTGTCAACAG >In-frame_ENST00000541666_ENST00000268379_TCGA-BR-8080-01A_HABP2_chr10_115312949_+_UQCRC2_chr16_21969856_length(amino acids)=387AA_start in transcript=50_stop in transcript=1213 MFARMSDLHVLLLMALVGKTACGTTKGASSFKITRGIEAVGGKLSVTATRENMAYTVECLRGDVDILMEFLLNVTTAPEFRRWEVADLQP QLKIDKAVAFQNPQTHVIENLHAAAYRNALANPLYCPDYRIGKVTSEELHYFVQNHFTSARMALIGLGVSHPVLKQVAEQFLNMRGGLGL SGAKANYRGGEIREQNGDSLVHAAFVAESAVAGSAEANAFSVLQHVLGAGPHVKRGSNTTSHLHQAVAKATQQPFDVSAFNASYSDSGLF GIYTISQATAAGDVIKAAYNQVKTIAQGNLSNTDVQAAKNKLKAGYLMSVESSECFLEEVGSQALVAGSYMPPSTVLQQIDSVANADIIN -------------------------------------------------------------- >In-frame_ENST00000541666_ENST00000561553_TCGA-BR-8080-01A_HABP2_chr10_115312949_+_UQCRC2_chr16_21969856_length(transcript)=1214nt_BP=119nt AACAAAAGAAATTTTATTGAGAGGAAAACACAAGTCCTTAAACTGCAAAGATGTTTGCCAGGATGTCTGATCTCCATGTTCTGCTGTTAA TGGCTCTGGTGGGAAAGACAGCCTGTGGGACGACAAAAGGAGCTTCATCTTTCAAGATAACCCGTGGAATTGAAGCAGTTGGTGGCAAAT TAAGTGTGACCGCAACAAGGGAAAACATGGCTTATACTGTGGAATGCCTGCGGGGTGATGTTGATATTCTAATGGAGTTCCTGCTCAATG TCACCACAGCACCAGAATTTCGTCGTTGGGAAGTAGCTGACCTTCAGCCTCAGCTAAAGATTGACAAAGCTGTGGCCTTTCAGAATCCGC AGACTCATGTCATTGAAAATTTGCATGCAGCAGCTTACCGGAATGCCTTGGCTAATCCCTTGTATTGTCCTGACTATAGGATTGGAAAAG TGACATCAGAGGAGTTACATTACTTCGTTCAGAACCATTTCACAAGTGCAAGAATGGCTTTGATTGGACTTGGTGTGAGTCATCCTGTTC TAAAGCAAGTTGCTGAACAGTTTCTCAACATGAGGGGTGGGCTTGGTTTATCTGGTGCAAAGGCCAACTACCGTGGAGGTGAAATCCGAG AACAGAATGGAGACAGTCTTGTCCATGCTGCTTTTGTAGCAGAAAGTGCTGTCGCGGGAAGTGCAGAGGCAAATGCATTTAGTGTTCTTC AGCATGTCCTCGGTGCTGGGCCACATGTCAAGAGGGGCAGCAACACCACCAGCCATCTGCACCAGGCTGTTGCCAAGGCAACTCAGCAGC CATTTGATGTTTCTGCATTTAATGCCAGTTACTCAGATTCTGGACTCTTTGGGATTTATACTATCTCCCAGGCCACAGCTGCTGGAGATG TTATCAAGGCTGCCTATAATCAAGTAAAAACAATAGCTCAAGGAAACCTTTCCAACACAGATGTCCAAGCTGCCAAGCGGCAAAGAAGTT TGTTTCTGGCCAGAAGTCAATGGCAGCAAGTGGAAATTTGGGACATACACCTTTTGTTGATGAGTTGTAATACTGATGCACACATTACAG GAGAGAGCTGAACGTTCTCTCAGCCCAGAGCAGCAAACACATGAAAGTCAGAAGTCTCTAATATATCATTTGTCTTTTTTCCAGTGAGGT >In-frame_ENST00000541666_ENST00000561553_TCGA-BR-8080-01A_HABP2_chr10_115312949_+_UQCRC2_chr16_21969856_length(amino acids)=346AA_start in transcript=50_stop in transcript=1090 MFARMSDLHVLLLMALVGKTACGTTKGASSFKITRGIEAVGGKLSVTATRENMAYTVECLRGDVDILMEFLLNVTTAPEFRRWEVADLQP QLKIDKAVAFQNPQTHVIENLHAAAYRNALANPLYCPDYRIGKVTSEELHYFVQNHFTSARMALIGLGVSHPVLKQVAEQFLNMRGGLGL SGAKANYRGGEIREQNGDSLVHAAFVAESAVAGSAEANAFSVLQHVLGAGPHVKRGSNTTSHLHQAVAKATQQPFDVSAFNASYSDSGLF -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for HABP2-UQCRC2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for HABP2-UQCRC2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | HABP2 | Q14520 | DB08818 | Hyaluronic acid | Binder | Small molecule | Approved|Vet_approved |
Hgene | HABP2 | Q14520 | DB08818 | Hyaluronic acid | Binder | Small molecule | Approved|Vet_approved |
Hgene | HABP2 | Q14520 | DB08818 | Hyaluronic acid | Binder | Small molecule | Approved|Vet_approved |
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Related Diseases for HABP2-UQCRC2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HABP2 | C4225292 | THYROID CANCER, NONMEDULLARY, 5 | 3 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | HABP2 | C0000786 | Spontaneous abortion | 1 | CTD_human |
Hgene | HABP2 | C0000822 | Abortion, Tubal | 1 | CTD_human |
Hgene | HABP2 | C3830362 | Early Pregnancy Loss | 1 | CTD_human |
Hgene | HABP2 | C4552766 | Miscarriage | 1 | CTD_human |
Tgene | UQCRC2 | C0028754 | Obesity | 1 | CTD_human |
Tgene | UQCRC2 | C3554608 | MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 5 | 1 | GENOMICS_ENGLAND;UNIPROT |