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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:HBS1L-POLN (FusionGDB2 ID:35589) |
Fusion Gene Summary for HBS1L-POLN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HBS1L-POLN | Fusion gene ID: 35589 | Hgene | Tgene | Gene symbol | HBS1L | POLN | Gene ID | 10767 | 353497 |
| Gene name | HBS1 like translational GTPase | DNA polymerase nu | |
| Synonyms | EF-1a|ERFS|HBS1|HSPC276|eRF3c | POL4P | |
| Cytomap | 6q23.3 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | HBS1-like proteinERF3-similar proteinHsp70 subfamily B suppressor 1-like proteineRF3 family member | DNA polymerase nuDNA polymerase NDNA polymerase POL4Ppolymerase (DNA directed) nupolymerase (DNA) nu | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9Y450 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000367837, ENST00000527578, ENST00000415177, ENST00000367826, ENST00000367824, ENST00000445176, ENST00000314674, ENST00000367822, ENST00000367820, ENST00000525067, | ENST00000382865, ENST00000511885, ENST00000515357, | |
| Fusion gene scores | * DoF score | 6 X 5 X 6=180 | 17 X 13 X 10=2210 |
| # samples | 7 | 21 | |
| ** MAII score | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(21/2210*10)=-3.39558513661267 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HBS1L [Title/Abstract] AND POLN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | HBS1L(135360710)-POLN(2087471), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | POLN | GO:0019985 | translesion synthesis | 20102227 |
| Fusion gene breakpoints across HBS1L (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across POLN (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LIHC | TCGA-CC-A7IH | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| ChimerDB4 | LIHC | TCGA-EP-A26S | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
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Fusion Gene ORF analysis for HBS1L-POLN |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000367837 | ENST00000382865 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| In-frame | ENST00000367837 | ENST00000511885 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| 5CDS-intron | ENST00000367837 | ENST00000515357 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| intron-3CDS | ENST00000527578 | ENST00000382865 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| intron-3CDS | ENST00000527578 | ENST00000511885 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| intron-intron | ENST00000527578 | ENST00000515357 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| intron-3CDS | ENST00000415177 | ENST00000382865 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| intron-3CDS | ENST00000415177 | ENST00000511885 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| intron-intron | ENST00000415177 | ENST00000515357 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| In-frame | ENST00000367826 | ENST00000382865 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| In-frame | ENST00000367826 | ENST00000511885 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| 5CDS-intron | ENST00000367826 | ENST00000515357 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| intron-3CDS | ENST00000367824 | ENST00000382865 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| intron-3CDS | ENST00000367824 | ENST00000511885 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| intron-intron | ENST00000367824 | ENST00000515357 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| intron-3CDS | ENST00000445176 | ENST00000382865 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| intron-3CDS | ENST00000445176 | ENST00000511885 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| intron-intron | ENST00000445176 | ENST00000515357 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| In-frame | ENST00000314674 | ENST00000382865 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| In-frame | ENST00000314674 | ENST00000511885 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| 5CDS-intron | ENST00000314674 | ENST00000515357 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| In-frame | ENST00000367822 | ENST00000382865 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| In-frame | ENST00000367822 | ENST00000511885 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| 5CDS-intron | ENST00000367822 | ENST00000515357 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| In-frame | ENST00000367820 | ENST00000382865 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| In-frame | ENST00000367820 | ENST00000511885 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| 5CDS-intron | ENST00000367820 | ENST00000515357 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| In-frame | ENST00000525067 | ENST00000382865 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| In-frame | ENST00000525067 | ENST00000511885 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| 5CDS-intron | ENST00000525067 | ENST00000515357 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000367837 | HBS1L | chr6 | 135360710 | - | ENST00000382865 | POLN | chr4 | 2087471 | - | 1471 | 637 | 207 | 1274 | 355 |
| ENST00000367837 | HBS1L | chr6 | 135360710 | - | ENST00000511885 | POLN | chr4 | 2087471 | - | 1471 | 637 | 207 | 1274 | 355 |
| ENST00000367826 | HBS1L | chr6 | 135360710 | - | ENST00000382865 | POLN | chr4 | 2087471 | - | 1266 | 432 | 128 | 1069 | 313 |
| ENST00000367826 | HBS1L | chr6 | 135360710 | - | ENST00000511885 | POLN | chr4 | 2087471 | - | 1266 | 432 | 128 | 1069 | 313 |
| ENST00000314674 | HBS1L | chr6 | 135360710 | - | ENST00000382865 | POLN | chr4 | 2087471 | - | 1376 | 542 | 112 | 1179 | 355 |
| ENST00000314674 | HBS1L | chr6 | 135360710 | - | ENST00000511885 | POLN | chr4 | 2087471 | - | 1376 | 542 | 112 | 1179 | 355 |
| ENST00000367822 | HBS1L | chr6 | 135360710 | - | ENST00000382865 | POLN | chr4 | 2087471 | - | 1457 | 623 | 193 | 1260 | 355 |
| ENST00000367822 | HBS1L | chr6 | 135360710 | - | ENST00000511885 | POLN | chr4 | 2087471 | - | 1457 | 623 | 193 | 1260 | 355 |
| ENST00000367820 | HBS1L | chr6 | 135360710 | - | ENST00000382865 | POLN | chr4 | 2087471 | - | 1373 | 539 | 109 | 1176 | 355 |
| ENST00000367820 | HBS1L | chr6 | 135360710 | - | ENST00000511885 | POLN | chr4 | 2087471 | - | 1373 | 539 | 109 | 1176 | 355 |
| ENST00000525067 | HBS1L | chr6 | 135360710 | - | ENST00000382865 | POLN | chr4 | 2087471 | - | 1233 | 399 | 161 | 1036 | 291 |
| ENST00000525067 | HBS1L | chr6 | 135360710 | - | ENST00000511885 | POLN | chr4 | 2087471 | - | 1233 | 399 | 161 | 1036 | 291 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000367837 | ENST00000382865 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - | 0.008872327 | 0.99112767 |
| ENST00000367837 | ENST00000511885 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - | 0.008872327 | 0.99112767 |
| ENST00000367826 | ENST00000382865 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - | 0.005785403 | 0.9942146 |
| ENST00000367826 | ENST00000511885 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - | 0.005785403 | 0.9942146 |
| ENST00000314674 | ENST00000382865 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - | 0.007294476 | 0.9927055 |
| ENST00000314674 | ENST00000511885 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - | 0.007294476 | 0.9927055 |
| ENST00000367822 | ENST00000382865 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - | 0.008684593 | 0.99131536 |
| ENST00000367822 | ENST00000511885 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - | 0.008684593 | 0.99131536 |
| ENST00000367820 | ENST00000382865 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - | 0.007207796 | 0.99279225 |
| ENST00000367820 | ENST00000511885 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - | 0.007207796 | 0.99279225 |
| ENST00000525067 | ENST00000382865 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - | 0.020053796 | 0.9799462 |
| ENST00000525067 | ENST00000511885 | HBS1L | chr6 | 135360710 | - | POLN | chr4 | 2087471 | - | 0.020053796 | 0.9799462 |
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Fusion Genomic Features for HBS1L-POLN |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for HBS1L-POLN |
| Go to FGviewer for the breakpoints of chr6:135360710-chr4:2087471 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HBS1L | . |
| FUNCTION: Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway (PubMed:21448132). In the presence of ABCE1 and PELO, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (PubMed:21448132). Together with PELO and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (PubMed:21448132). {ECO:0000269|PubMed:21448132}.; FUNCTION: [Isoform 2]: Facilitates the association of the exosome complex with the SKI complex. {ECO:0000269|PubMed:28204585}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367822 | - | 4 | 5 | 258_482 | 143.33333333333334 | 633.0 | Domain | tr-type G |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367826 | - | 3 | 17 | 258_482 | 101.33333333333333 | 643.0 | Domain | tr-type G |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367837 | - | 4 | 18 | 258_482 | 143.33333333333334 | 685.0 | Domain | tr-type G |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367822 | - | 4 | 5 | 344_348 | 143.33333333333334 | 633.0 | Nucleotide binding | GTP |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367826 | - | 3 | 17 | 344_348 | 101.33333333333333 | 643.0 | Nucleotide binding | GTP |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367837 | - | 4 | 18 | 344_348 | 143.33333333333334 | 685.0 | Nucleotide binding | GTP |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367822 | - | 4 | 5 | 267_274 | 143.33333333333334 | 633.0 | Region | G1 |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367822 | - | 4 | 5 | 323_327 | 143.33333333333334 | 633.0 | Region | G2 |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367822 | - | 4 | 5 | 344_347 | 143.33333333333334 | 633.0 | Region | G3 |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367822 | - | 4 | 5 | 406_409 | 143.33333333333334 | 633.0 | Region | G4 |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367822 | - | 4 | 5 | 445_447 | 143.33333333333334 | 633.0 | Region | G5 |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367826 | - | 3 | 17 | 267_274 | 101.33333333333333 | 643.0 | Region | G1 |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367826 | - | 3 | 17 | 323_327 | 101.33333333333333 | 643.0 | Region | G2 |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367826 | - | 3 | 17 | 344_347 | 101.33333333333333 | 643.0 | Region | G3 |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367826 | - | 3 | 17 | 406_409 | 101.33333333333333 | 643.0 | Region | G4 |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367826 | - | 3 | 17 | 445_447 | 101.33333333333333 | 643.0 | Region | G5 |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367837 | - | 4 | 18 | 267_274 | 143.33333333333334 | 685.0 | Region | G1 |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367837 | - | 4 | 18 | 323_327 | 143.33333333333334 | 685.0 | Region | G2 |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367837 | - | 4 | 18 | 344_347 | 143.33333333333334 | 685.0 | Region | G3 |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367837 | - | 4 | 18 | 406_409 | 143.33333333333334 | 685.0 | Region | G4 |
| Hgene | HBS1L | chr6:135360710 | chr4:2087471 | ENST00000367837 | - | 4 | 18 | 445_447 | 143.33333333333334 | 685.0 | Region | G5 |
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Fusion Gene Sequence for HBS1L-POLN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000367837_ENST00000382865_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(transcript)=1471nt_BP=637nt AGGGAGGCGGACAGTGACCCTGAGGCATTGCCGTCGCGCGGTGCACAGCTAAGACGTCGCGCTTGCGCAGGCGCTCGGCGCAGAGGCCTG CGGGAAGCCAAGATGGCGCATAGGGGTTCTCCAGGCTGCAGTTGGCGCCTTATCAGTATCTAAGCGGAGTGTTTTGGAAGGAGTTAAGGG GCTGTGGCAAACGCCCTCTCCGCCGTCATGGCCCGGCATCGGAATGTTCGAGGCTATAACTACGATGAAGATTTTGAAGATGATGATCTC TACGGCCAGTCTGTAGAGGATGATTATTGTATTTCGCCGTCAACAGCTGCTCAGTTTATTTATTCACGGCGTGACAAACCTTCCGTTGAG CCTGTGGAAGAATATGATTATGAAGATCTGAAAGAATCTTCCAATTCTGTTTCAAACCATCAGCTCAGTGGATTTGATCAAGCTCGTCTT TATTCATGCCTTGATCACATGAGAGAGGTACTTGGAGATGCTGTGCCAGATGAAATATTAATTGAAGCAGTTCTGAAGAACAAGTTTGAT GTGCAGAAGGCTTTGTCAGGGGTTCTGGAACAAGATAGAGTGCAGAGTTTGAAGGACAAGAATGAGGCAACAGTATCTACAGGAAAGATA GCAAAAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAG AAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCA AGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGC AAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTG TTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTG CAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCA GGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCT TCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCTCT GTACGCCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTTGT >In-frame_ENST00000367837_ENST00000382865_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(amino acids)=355AA_start in transcript=207_stop in transcript=1274 MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSVEPVEEYDYEDLKESSNSVSNHQLSGFDQARLYSCLDHMRE VLGDAVPDEILIEAVLKNKFDVQKALSGVLEQDRVQSLKDKNEATVSTGKIAKGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAA IAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIP -------------------------------------------------------------- >In-frame_ENST00000367837_ENST00000511885_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(transcript)=1471nt_BP=637nt AGGGAGGCGGACAGTGACCCTGAGGCATTGCCGTCGCGCGGTGCACAGCTAAGACGTCGCGCTTGCGCAGGCGCTCGGCGCAGAGGCCTG CGGGAAGCCAAGATGGCGCATAGGGGTTCTCCAGGCTGCAGTTGGCGCCTTATCAGTATCTAAGCGGAGTGTTTTGGAAGGAGTTAAGGG GCTGTGGCAAACGCCCTCTCCGCCGTCATGGCCCGGCATCGGAATGTTCGAGGCTATAACTACGATGAAGATTTTGAAGATGATGATCTC TACGGCCAGTCTGTAGAGGATGATTATTGTATTTCGCCGTCAACAGCTGCTCAGTTTATTTATTCACGGCGTGACAAACCTTCCGTTGAG CCTGTGGAAGAATATGATTATGAAGATCTGAAAGAATCTTCCAATTCTGTTTCAAACCATCAGCTCAGTGGATTTGATCAAGCTCGTCTT TATTCATGCCTTGATCACATGAGAGAGGTACTTGGAGATGCTGTGCCAGATGAAATATTAATTGAAGCAGTTCTGAAGAACAAGTTTGAT GTGCAGAAGGCTTTGTCAGGGGTTCTGGAACAAGATAGAGTGCAGAGTTTGAAGGACAAGAATGAGGCAACAGTATCTACAGGAAAGATA GCAAAAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAG AAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCA AGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGC AAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTG TTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTG CAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCA GGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCT TCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCTCT GTACGCCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTTGT >In-frame_ENST00000367837_ENST00000511885_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(amino acids)=355AA_start in transcript=207_stop in transcript=1274 MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSVEPVEEYDYEDLKESSNSVSNHQLSGFDQARLYSCLDHMRE VLGDAVPDEILIEAVLKNKFDVQKALSGVLEQDRVQSLKDKNEATVSTGKIAKGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAA IAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIP -------------------------------------------------------------- >In-frame_ENST00000367826_ENST00000382865_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(transcript)=1266nt_BP=432nt GCAGAGGCCTGCGGGAAGCCAAGATGGCGCATAGGGGTTCTCCAGGCTGCAGTTGGCGCCTTATCAGTATCTAAGCGGAGTGTTTTGGAA GGAGTTAAGGGGCTGTGGCAAACGCCCTCTCCGCCGTCATGGCCCGGCATCGGAATGTTCGAGGCTATAACTACGATGAAGATTTTGAAG ATGATGATCTCTACGGCCAGTCTGTAGAGGATGATTATTGTATTTCGCCGTCAACAGCTCGTCTTTATTCATGCCTTGATCACATGAGAG AGGTACTTGGAGATGCTGTGCCAGATGAAATATTAATTGAAGCAGTTCTGAAGAACAAGTTTGATGTGCAGAAGGCTTTGTCAGGGGTTC TGGAACAAGATAGAGTGCAGAGTTTGAAGGACAAGAATGAGGCAACAGTATCTACAGGAAAGATAGCAAAAGGGAAGGAGCGGCTGGCTG CTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAAATCAAGGACTTCGCCCGAGCAG CTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGGATTCACGCTCATGACCAGCAAC TCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAGCTGGCCATGATCCATGTCTTCA CTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTTGAAGTGGAAGATCCGCAGATCC CGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAGCTTCAGGTACCCCTCAAGGTGA GCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGCCCATGTCGCACTGAGTCTCCCA GCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCATTTTGTCTGTAGCCCCAGGCAA CAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCTCTGTACGCCCCAGGACGCATTAACCCT TTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTTGTCTGAGTGAATTCTTCCTGTGAGTGG >In-frame_ENST00000367826_ENST00000382865_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(amino acids)=313AA_start in transcript=128_stop in transcript=1069 MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTARLYSCLDHMREVLGDAVPDEILIEAVLKNKFDVQKALSGVLEQDRVQSLKDKN EATVSTGKIAKGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFV VQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVP -------------------------------------------------------------- >In-frame_ENST00000367826_ENST00000511885_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(transcript)=1266nt_BP=432nt GCAGAGGCCTGCGGGAAGCCAAGATGGCGCATAGGGGTTCTCCAGGCTGCAGTTGGCGCCTTATCAGTATCTAAGCGGAGTGTTTTGGAA GGAGTTAAGGGGCTGTGGCAAACGCCCTCTCCGCCGTCATGGCCCGGCATCGGAATGTTCGAGGCTATAACTACGATGAAGATTTTGAAG ATGATGATCTCTACGGCCAGTCTGTAGAGGATGATTATTGTATTTCGCCGTCAACAGCTCGTCTTTATTCATGCCTTGATCACATGAGAG AGGTACTTGGAGATGCTGTGCCAGATGAAATATTAATTGAAGCAGTTCTGAAGAACAAGTTTGATGTGCAGAAGGCTTTGTCAGGGGTTC TGGAACAAGATAGAGTGCAGAGTTTGAAGGACAAGAATGAGGCAACAGTATCTACAGGAAAGATAGCAAAAGGGAAGGAGCGGCTGGCTG CTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAAATCAAGGACTTCGCCCGAGCAG CTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGGATTCACGCTCATGACCAGCAAC TCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAGCTGGCCATGATCCATGTCTTCA CTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTTGAAGTGGAAGATCCGCAGATCC CGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAGCTTCAGGTACCCCTCAAGGTGA GCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGCCCATGTCGCACTGAGTCTCCCA GCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCATTTTGTCTGTAGCCCCAGGCAA CAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCTCTGTACGCCCCAGGACGCATTAACCCT TTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTTGTCTGAGTGAATTCTTCCTGTGAGTGG >In-frame_ENST00000367826_ENST00000511885_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(amino acids)=313AA_start in transcript=128_stop in transcript=1069 MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTARLYSCLDHMREVLGDAVPDEILIEAVLKNKFDVQKALSGVLEQDRVQSLKDKN EATVSTGKIAKGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFV VQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVP -------------------------------------------------------------- >In-frame_ENST00000314674_ENST00000382865_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(transcript)=1376nt_BP=542nt AGCCAAGATGGCGCATAGGGGTTCTCCAGGCTGCAGTTGGCGCCTTATCAGTATCTAAGCGGAGTGTTTTGGAAGGAGTTAAGGGGCTGT GGCAAACGCCCTCTCCGCCGTCATGGCCCGGCATCGGAATGTTCGAGGCTATAACTACGATGAAGATTTTGAAGATGATGATCTCTACGG CCAGTCTGTAGAGGATGATTATTGTATTTCGCCGTCAACAGCTGCTCAGTTTATTTATTCACGGCGTGACAAACCTTCCGTTGAGCCTGT GGAAGAATATGATTATGAAGATCTGAAAGAATCTTCCAATTCTGTTTCAAACCATCAGCTCAGTGGATTTGATCAAGCTCGTCTTTATTC ATGCCTTGATCACATGAGAGAGGTACTTGGAGATGCTGTGCCAGATGAAATATTAATTGAAGCAGTTCTGAAGAACAAGTTTGATGTGCA GAAGGCTTTGTCAGGGGTTCTGGAACAAGATAGAGTGCAGAGTTTGAAGGACAAGAATGAGGCAACAGTATCTACAGGAAAGATAGCAAA AGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAAAT CAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGGAT TCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAGCT GGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTTGA AGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAGCT TCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGCCC ATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCATT TTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCTCTGTACG CCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTTGTCTGAG >In-frame_ENST00000314674_ENST00000382865_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(amino acids)=355AA_start in transcript=112_stop in transcript=1179 MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSVEPVEEYDYEDLKESSNSVSNHQLSGFDQARLYSCLDHMRE VLGDAVPDEILIEAVLKNKFDVQKALSGVLEQDRVQSLKDKNEATVSTGKIAKGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAA IAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIP -------------------------------------------------------------- >In-frame_ENST00000314674_ENST00000511885_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(transcript)=1376nt_BP=542nt AGCCAAGATGGCGCATAGGGGTTCTCCAGGCTGCAGTTGGCGCCTTATCAGTATCTAAGCGGAGTGTTTTGGAAGGAGTTAAGGGGCTGT GGCAAACGCCCTCTCCGCCGTCATGGCCCGGCATCGGAATGTTCGAGGCTATAACTACGATGAAGATTTTGAAGATGATGATCTCTACGG CCAGTCTGTAGAGGATGATTATTGTATTTCGCCGTCAACAGCTGCTCAGTTTATTTATTCACGGCGTGACAAACCTTCCGTTGAGCCTGT GGAAGAATATGATTATGAAGATCTGAAAGAATCTTCCAATTCTGTTTCAAACCATCAGCTCAGTGGATTTGATCAAGCTCGTCTTTATTC ATGCCTTGATCACATGAGAGAGGTACTTGGAGATGCTGTGCCAGATGAAATATTAATTGAAGCAGTTCTGAAGAACAAGTTTGATGTGCA GAAGGCTTTGTCAGGGGTTCTGGAACAAGATAGAGTGCAGAGTTTGAAGGACAAGAATGAGGCAACAGTATCTACAGGAAAGATAGCAAA AGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAAAT CAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGGAT TCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAGCT GGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTTGA AGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAGCT TCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGCCC ATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCATT TTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCTCTGTACG CCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTTGTCTGAG >In-frame_ENST00000314674_ENST00000511885_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(amino acids)=355AA_start in transcript=112_stop in transcript=1179 MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSVEPVEEYDYEDLKESSNSVSNHQLSGFDQARLYSCLDHMRE VLGDAVPDEILIEAVLKNKFDVQKALSGVLEQDRVQSLKDKNEATVSTGKIAKGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAA IAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIP -------------------------------------------------------------- >In-frame_ENST00000367822_ENST00000382865_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(transcript)=1457nt_BP=623nt TGACCCTGAGGCATTGCCGTCGCGCGGTGCACAGCTAAGACGTCGCGCTTGCGCAGGCGCTCGGCGCAGAGGCCTGCGGGAAGCCAAGAT GGCGCATAGGGGTTCTCCAGGCTGCAGTTGGCGCCTTATCAGTATCTAAGCGGAGTGTTTTGGAAGGAGTTAAGGGGCTGTGGCAAACGC CCTCTCCGCCGTCATGGCCCGGCATCGGAATGTTCGAGGCTATAACTACGATGAAGATTTTGAAGATGATGATCTCTACGGCCAGTCTGT AGAGGATGATTATTGTATTTCGCCGTCAACAGCTGCTCAGTTTATTTATTCACGGCGTGACAAACCTTCCGTTGAGCCTGTGGAAGAATA TGATTATGAAGATCTGAAAGAATCTTCCAATTCTGTTTCAAACCATCAGCTCAGTGGATTTGATCAAGCTCGTCTTTATTCATGCCTTGA TCACATGAGAGAGGTACTTGGAGATGCTGTGCCAGATGAAATATTAATTGAAGCAGTTCTGAAGAACAAGTTTGATGTGCAGAAGGCTTT GTCAGGGGTTCTGGAACAAGATAGAGTGCAGAGTTTGAAGGACAAGAATGAGGCAACAGTATCTACAGGAAAGATAGCAAAAGGGAAGGA GCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAAATCAAGGACTT CGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGGATTCACGCTCA TGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAGCTGGCCATGAT CCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTTGAAGTGGAAGA TCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAGCTTCAGGTACC CCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGCCCATGTCGCAC TGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCATTTTGTCTGTA GCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCTCTGTACGCCCCAGGAC GCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTTGTCTGAGTGAATTCTT >In-frame_ENST00000367822_ENST00000382865_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(amino acids)=355AA_start in transcript=193_stop in transcript=1260 MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSVEPVEEYDYEDLKESSNSVSNHQLSGFDQARLYSCLDHMRE VLGDAVPDEILIEAVLKNKFDVQKALSGVLEQDRVQSLKDKNEATVSTGKIAKGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAA IAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIP -------------------------------------------------------------- >In-frame_ENST00000367822_ENST00000511885_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(transcript)=1457nt_BP=623nt TGACCCTGAGGCATTGCCGTCGCGCGGTGCACAGCTAAGACGTCGCGCTTGCGCAGGCGCTCGGCGCAGAGGCCTGCGGGAAGCCAAGAT GGCGCATAGGGGTTCTCCAGGCTGCAGTTGGCGCCTTATCAGTATCTAAGCGGAGTGTTTTGGAAGGAGTTAAGGGGCTGTGGCAAACGC CCTCTCCGCCGTCATGGCCCGGCATCGGAATGTTCGAGGCTATAACTACGATGAAGATTTTGAAGATGATGATCTCTACGGCCAGTCTGT AGAGGATGATTATTGTATTTCGCCGTCAACAGCTGCTCAGTTTATTTATTCACGGCGTGACAAACCTTCCGTTGAGCCTGTGGAAGAATA TGATTATGAAGATCTGAAAGAATCTTCCAATTCTGTTTCAAACCATCAGCTCAGTGGATTTGATCAAGCTCGTCTTTATTCATGCCTTGA TCACATGAGAGAGGTACTTGGAGATGCTGTGCCAGATGAAATATTAATTGAAGCAGTTCTGAAGAACAAGTTTGATGTGCAGAAGGCTTT GTCAGGGGTTCTGGAACAAGATAGAGTGCAGAGTTTGAAGGACAAGAATGAGGCAACAGTATCTACAGGAAAGATAGCAAAAGGGAAGGA GCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAAATCAAGGACTT CGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGGATTCACGCTCA TGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAGCTGGCCATGAT CCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTTGAAGTGGAAGA TCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAGCTTCAGGTACC CCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGCCCATGTCGCAC TGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCATTTTGTCTGTA GCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCTCTGTACGCCCCAGGAC GCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTTGTCTGAGTGAATTCTT >In-frame_ENST00000367822_ENST00000511885_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(amino acids)=355AA_start in transcript=193_stop in transcript=1260 MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSVEPVEEYDYEDLKESSNSVSNHQLSGFDQARLYSCLDHMRE VLGDAVPDEILIEAVLKNKFDVQKALSGVLEQDRVQSLKDKNEATVSTGKIAKGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAA IAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIP -------------------------------------------------------------- >In-frame_ENST00000367820_ENST00000382865_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(transcript)=1373nt_BP=539nt CAAGATGGCGCATAGGGGTTCTCCAGGCTGCAGTTGGCGCCTTATCAGTATCTAAGCGGAGTGTTTTGGAAGGAGTTAAGGGGCTGTGGC AAACGCCCTCTCCGCCGTCATGGCCCGGCATCGGAATGTTCGAGGCTATAACTACGATGAAGATTTTGAAGATGATGATCTCTACGGCCA GTCTGTAGAGGATGATTATTGTATTTCGCCGTCAACAGCTGCTCAGTTTATTTATTCACGGCGTGACAAACCTTCCGTTGAGCCTGTGGA AGAATATGATTATGAAGATCTGAAAGAATCTTCCAATTCTGTTTCAAACCATCAGCTCAGTGGATTTGATCAAGCTCGTCTTTATTCATG CCTTGATCACATGAGAGAGGTACTTGGAGATGCTGTGCCAGATGAAATATTAATTGAAGCAGTTCTGAAGAACAAGTTTGATGTGCAGAA GGCTTTGTCAGGGGTTCTGGAACAAGATAGAGTGCAGAGTTTGAAGGACAAGAATGAGGCAACAGTATCTACAGGAAAGATAGCAAAAGG GAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAAATCAA GGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGGATTCA CGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAGCTGGC CATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTTGAAGT GGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAGCTTCA GGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGCCCATG TCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCATTTTG TCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCTCTGTACGCCC CAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTTGTCTGAGTGA >In-frame_ENST00000367820_ENST00000382865_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(amino acids)=355AA_start in transcript=109_stop in transcript=1176 MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSVEPVEEYDYEDLKESSNSVSNHQLSGFDQARLYSCLDHMRE VLGDAVPDEILIEAVLKNKFDVQKALSGVLEQDRVQSLKDKNEATVSTGKIAKGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAA IAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIP -------------------------------------------------------------- >In-frame_ENST00000367820_ENST00000511885_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(transcript)=1373nt_BP=539nt CAAGATGGCGCATAGGGGTTCTCCAGGCTGCAGTTGGCGCCTTATCAGTATCTAAGCGGAGTGTTTTGGAAGGAGTTAAGGGGCTGTGGC AAACGCCCTCTCCGCCGTCATGGCCCGGCATCGGAATGTTCGAGGCTATAACTACGATGAAGATTTTGAAGATGATGATCTCTACGGCCA GTCTGTAGAGGATGATTATTGTATTTCGCCGTCAACAGCTGCTCAGTTTATTTATTCACGGCGTGACAAACCTTCCGTTGAGCCTGTGGA AGAATATGATTATGAAGATCTGAAAGAATCTTCCAATTCTGTTTCAAACCATCAGCTCAGTGGATTTGATCAAGCTCGTCTTTATTCATG CCTTGATCACATGAGAGAGGTACTTGGAGATGCTGTGCCAGATGAAATATTAATTGAAGCAGTTCTGAAGAACAAGTTTGATGTGCAGAA GGCTTTGTCAGGGGTTCTGGAACAAGATAGAGTGCAGAGTTTGAAGGACAAGAATGAGGCAACAGTATCTACAGGAAAGATAGCAAAAGG GAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAAATCAA GGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGGATTCA CGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAGCTGGC CATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTTGAAGT GGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAGCTTCA GGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGCCCATG TCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCATTTTG TCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCTCTGTACGCCC CAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTTGTCTGAGTGA >In-frame_ENST00000367820_ENST00000511885_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(amino acids)=355AA_start in transcript=109_stop in transcript=1176 MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSVEPVEEYDYEDLKESSNSVSNHQLSGFDQARLYSCLDHMRE VLGDAVPDEILIEAVLKNKFDVQKALSGVLEQDRVQSLKDKNEATVSTGKIAKGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAA IAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIP -------------------------------------------------------------- >In-frame_ENST00000525067_ENST00000382865_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(transcript)=1233nt_BP=399nt AGCTAAGACGTCGCGCTTGCGCAGGCGCTCGGCGCAGAGGCCTGCGGGAAGCCAAGATGGCGCATAGGGGTTCTCCAGGCTGCAGTTGGC GCCTTATCAGTATCTAAGCGGAGTGTTTTGGAAGGAGTTAAGGGGCTGTGGCAAACGCCCTCTCCGCCGTCATGGCCCGGCATCGGAATG TTCGAGGCTATAACTACGATGAAGCTCGTCTTTATTCATGCCTTGATCACATGAGAGAGGTACTTGGAGATGCTGTGCCAGATGAAATAT TAATTGAAGCAGTTCTGAAGAACAAGTTTGATGTGCAGAAGGCTTTGTCAGGGGTTCTGGAACAAGATAGAGTGCAGAGTTTGAAGGACA AGAATGAGGCAACAGTATCTACAGGAAAGATAGCAAAAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCC AGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGG TGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACT TCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCA GGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGG AGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGG TGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCA GCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCC ATTGTGTGGCCTTCCCCAAGGTCACCAGCTCTGTACGCCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGT >In-frame_ENST00000525067_ENST00000382865_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(amino acids)=291AA_start in transcript=161_stop in transcript=1036 MARHRNVRGYNYDEARLYSCLDHMREVLGDAVPDEILIEAVLKNKFDVQKALSGVLEQDRVQSLKDKNEATVSTGKIAKGKERLAACLGV PIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAA SHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVPLQEAWGPPPGPCRTESPSNSLA -------------------------------------------------------------- >In-frame_ENST00000525067_ENST00000511885_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(transcript)=1233nt_BP=399nt AGCTAAGACGTCGCGCTTGCGCAGGCGCTCGGCGCAGAGGCCTGCGGGAAGCCAAGATGGCGCATAGGGGTTCTCCAGGCTGCAGTTGGC GCCTTATCAGTATCTAAGCGGAGTGTTTTGGAAGGAGTTAAGGGGCTGTGGCAAACGCCCTCTCCGCCGTCATGGCCCGGCATCGGAATG TTCGAGGCTATAACTACGATGAAGCTCGTCTTTATTCATGCCTTGATCACATGAGAGAGGTACTTGGAGATGCTGTGCCAGATGAAATAT TAATTGAAGCAGTTCTGAAGAACAAGTTTGATGTGCAGAAGGCTTTGTCAGGGGTTCTGGAACAAGATAGAGTGCAGAGTTTGAAGGACA AGAATGAGGCAACAGTATCTACAGGAAAGATAGCAAAAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCC AGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGG TGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACT TCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCA GGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGG AGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGG TGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCA GCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCC ATTGTGTGGCCTTCCCCAAGGTCACCAGCTCTGTACGCCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGT >In-frame_ENST00000525067_ENST00000511885_TCGA-CC-A7IH_HBS1L_chr6_135360710_-_POLN_chr4_2087471_length(amino acids)=291AA_start in transcript=161_stop in transcript=1036 MARHRNVRGYNYDEARLYSCLDHMREVLGDAVPDEILIEAVLKNKFDVQKALSGVLEQDRVQSLKDKNEATVSTGKIAKGKERLAACLGV PIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAA SHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVPLQEAWGPPPGPCRTESPSNSLA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for HBS1L-POLN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for HBS1L-POLN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for HBS1L-POLN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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