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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HCP5-HLA-G (FusionGDB2 ID:35652)

Fusion Gene Summary for HCP5-HLA-G

Fusion gene summary

Fusion gene information	Fusion gene name: HCP5-HLA-G
	Fusion gene ID: 35652
		Hgene	Tgene
	Gene symbol	HCP5	HLA-G
	Gene ID	10866	3135
	Gene name	HLA complex P5	major histocompatibility complex, class I, G
	Synonyms	6S2650E\|D6S2650E\|P5-1	MHC-G
	Cytomap	6p21.33	6p22.1
	Type of gene	ncRNA	protein-coding
	Description	HLA class I histocompatibility antigen protein P5HLA complex P5 (non-protein coding)HLA complex protein P5MHC class I region ORF	HLA class I histocompatibility antigen, alpha chain GHLA G antigenHLA-G histocompatibility antigen, class I, GMHC class I antigen GMHC class Ib antigenb2 microglobulinmutant MHC class I antigenmutant MHC class Ib antigen
	Modification date	20200313	20200320
	UniProtAcc	.	P17693
	Ensembl transtripts involved in fusion gene	ENST00000414046, ENST00000419355, ENST00000457127, ENST00000423496,	ENST00000376828, ENST00000428701, ENST00000360323, ENST00000376818, ENST00000376815, ENST00000400665, ENST00000546545, ENST00000444098, ENST00000452715, ENST00000445373, ENST00000420559, ENST00000546634, ENST00000423373, ENST00000452577, ENST00000457132, ENST00000450984, ENST00000547931, ENST00000449127, ENST00000412263, ENST00000415687, ENST00000400682, ENST00000553052, ENST00000383621, ENST00000383622, ENST00000383623, ENST00000422371, ENST00000550897, ENST00000428952, ENST00000426863, ENST00000429890, ENST00000434881, ENST00000547241, ENST00000423011, ENST00000448306, ENST00000434907, ENST00000430253,
Fusion gene scores	* DoF score	8 X 5 X 6=240	2 X 2 X 2=8
	# samples	9	2
	** MAII score	log2(9/240*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: HCP5 [Title/Abstract] AND HLA-G [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HCP5(31431056)-HLA-G(29795823), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	HLA-G	GO:0001915	negative regulation of T cell mediated cytotoxicity	11290782
Tgene	HLA-G	GO:0002451	peripheral B cell tolerance induction	24453251
Tgene	HLA-G	GO:0002476	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	7584149\|8805247
Tgene	HLA-G	GO:0002729	positive regulation of natural killer cell cytokine production	16366734\|19304799\|23184984
Tgene	HLA-G	GO:0002767	immune response-inhibiting cell surface receptor signaling pathway	20702625
Tgene	HLA-G	GO:0016525	negative regulation of angiogenesis	16809620
Tgene	HLA-G	GO:0032735	positive regulation of interleukin-12 production	20702625
Tgene	HLA-G	GO:0042130	negative regulation of T cell proliferation	20702625
Tgene	HLA-G	GO:0042270	protection from natural killer cell mediated cytotoxicity	11290782
Tgene	HLA-G	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	10190900
Tgene	HLA-G	GO:0051898	negative regulation of protein kinase B signaling	24453251
Tgene	HLA-G	GO:0060907	positive regulation of macrophage cytokine production	19304799
Tgene	HLA-G	GO:0070207	protein homotrimerization	12874224
Tgene	HLA-G	GO:0070317	negative regulation of G0 to G1 transition	24453251
Tgene	HLA-G	GO:2000353	positive regulation of endothelial cell apoptotic process	16809620
Tgene	HLA-G	GO:2000774	positive regulation of cellular senescence	23184984
Tgene	HLA-G	GO:2001199	negative regulation of dendritic cell differentiation	20702625

Fusion gene breakpoints across HCP5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HLA-G (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-51-4080-11A	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+

Top

Fusion Gene ORF analysis for HCP5-HLA-G

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000414046	ENST00000376828	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-3CDS	ENST00000414046	ENST00000428701	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-3CDS	ENST00000414046	ENST00000360323	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-3CDS	ENST00000414046	ENST00000376818	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-3CDS	ENST00000414046	ENST00000376815	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000400665	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000546545	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000444098	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000452715	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000445373	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000420559	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000546634	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000423373	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000452577	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000457132	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000450984	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000547931	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000449127	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000412263	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000415687	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000400682	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000553052	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000383621	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000383622	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000383623	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000422371	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000550897	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000428952	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000426863	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000429890	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000434881	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000547241	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000423011	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000448306	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000434907	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
3UTR-intron	ENST00000414046	ENST00000430253	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-3CDS	ENST00000419355	ENST00000376828	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-3CDS	ENST00000419355	ENST00000428701	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-3CDS	ENST00000419355	ENST00000360323	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-3CDS	ENST00000419355	ENST00000376818	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-3CDS	ENST00000419355	ENST00000376815	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000400665	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000546545	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000444098	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000452715	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000445373	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000420559	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000546634	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000423373	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000452577	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000457132	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000450984	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000547931	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000449127	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000412263	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000415687	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000400682	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000553052	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000383621	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000383622	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000383623	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000422371	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000550897	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000428952	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000426863	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000429890	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000434881	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000547241	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000423011	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000448306	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000434907	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000419355	ENST00000430253	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-3CDS	ENST00000457127	ENST00000376828	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-3CDS	ENST00000457127	ENST00000428701	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-3CDS	ENST00000457127	ENST00000360323	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-3CDS	ENST00000457127	ENST00000376818	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-3CDS	ENST00000457127	ENST00000376815	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000400665	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000546545	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000444098	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000452715	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000445373	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000420559	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000546634	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000423373	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000452577	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000457132	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000450984	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000547931	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000449127	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000412263	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000415687	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000400682	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000553052	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000383621	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000383622	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000383623	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000422371	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000550897	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000428952	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000426863	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000429890	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000434881	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000547241	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000423011	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000448306	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000434907	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000457127	ENST00000430253	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-3CDS	ENST00000423496	ENST00000376828	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-3CDS	ENST00000423496	ENST00000428701	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-3CDS	ENST00000423496	ENST00000360323	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-3CDS	ENST00000423496	ENST00000376818	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-3CDS	ENST00000423496	ENST00000376815	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000400665	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000546545	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000444098	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000452715	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000445373	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000420559	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000546634	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000423373	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000452577	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000457132	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000450984	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000547931	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000449127	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000412263	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000415687	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000400682	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000553052	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000383621	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000383622	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000383623	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000422371	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000550897	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000428952	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000426863	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000429890	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000434881	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000547241	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000423011	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000448306	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000434907	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+
intron-intron	ENST00000423496	ENST00000430253	HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for HCP5-HLA-G

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+	0.000131263	0.99986875
HCP5	chr6	31431056	+	HLA-G	chr6	29795823	+	0.000131263	0.99986875

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HCP5-HLA-G

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	HLA-G P17693
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: [Isoform 1]: Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:23184984, PubMed:29262349, PubMed:19304799). In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247). Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799, PubMed:20448110, PubMed:27859042). Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799). Through interaction with KIR2DL4 receptor on decidual macrophages induces proinflammatory cytokine production mainly associated with tissue remodeling (PubMed:19304799). Through interaction with LILRB2 receptor triggers differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:11290782, PubMed:24453251). Reprograms B cells toward an immune suppressive phenotype via LILRB1 (PubMed:24453251). May induce immune activation/suppression via intercellular membrane transfer (trogocytosis), likely enabling interaction with KIR2DL4, which resides mostly in endosomes (PubMed:20179272, PubMed:26460007). Through interaction with the inhibitory receptor CD160 on endothelial cells may control angiogenesis in immune privileged sites (PubMed:16809620). {ECO:0000269\|PubMed:10190900, ECO:0000269\|PubMed:11290782, ECO:0000269\|PubMed:16366734, ECO:0000269\|PubMed:16809620, ECO:0000269\|PubMed:19304799, ECO:0000269\|PubMed:20179272, ECO:0000269\|PubMed:20448110, ECO:0000269\|PubMed:23184984, ECO:0000269\|PubMed:24453251, ECO:0000269\|PubMed:26460007, ECO:0000269\|PubMed:27859042, ECO:0000269\|PubMed:29262349, ECO:0000269\|PubMed:7584149, ECO:0000269\|PubMed:8805247}.; FUNCTION: [Isoform 2]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782). {ECO:0000269\|PubMed:11290782, ECO:0000305}.; FUNCTION: [Isoform 3]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782). {ECO:0000269\|PubMed:11290782, ECO:0000305}.; FUNCTION: [Isoform 4]: Likely does not bind B2M and presents peptides. Negatively regulates NK cell- and CD8+ T cell-mediated cytotoxicity (PubMed:11290782). {ECO:0000269\|PubMed:11290782, ECO:0000305}.; FUNCTION: [Isoform 5]: Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:23184984, PubMed:29262349, PubMed:19304799). In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247). Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799, PubMed:20448110). Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799). Through interaction with KIR2DL4 receptor on decidual macrophages induces proinflammatory cytokine production mainly associated with tissue remodeling (PubMed:19304799). Through interaction with LILRB2 receptor triggers differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110). Reprograms B cells toward an immune suppressive phenotype via LILRB1 (PubMed:24453251). {ECO:0000269\|PubMed:16366734, ECO:0000269\|PubMed:19304799, ECO:0000269\|PubMed:20448110, ECO:0000269\|PubMed:23184984, ECO:0000269\|PubMed:24453251, ECO:0000269\|PubMed:29262349, ECO:0000269\|PubMed:7584149, ECO:0000269\|PubMed:8805247}.; FUNCTION: [Isoform 6]: Likely does not bind B2M and presents peptides. {ECO:0000305}.; FUNCTION: [Isoform 7]: Likely does not bind B2M and presents peptides. {ECO:0000305}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for HCP5-HLA-G

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HCP5-HLA-G

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HCP5-HLA-G

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HCP5-HLA-G

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	HLA-G	C0005586	Bipolar Disorder	1	PSYGENET