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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HDAC11-TEAD3 (FusionGDB2 ID:35684)

Fusion Gene Summary for HDAC11-TEAD3

check button Fusion gene summary
Fusion gene informationFusion gene name: HDAC11-TEAD3
Fusion gene ID: 35684
HgeneTgene
Gene symbol

HDAC11

TEAD3

Gene ID

79885

7005

Gene namehistone deacetylase 11TEA domain transcription factor 3
SynonymsHD11DTEF-1|ETFR-1|TEAD-3|TEAD5|TEF-5|TEF5
Cytomap

3p25.1

6p21.31

Type of geneprotein-codingprotein-coding
Descriptionhistone deacetylase 11transcriptional enhancer factor TEF-5TEA domain family member 3TEA domain family member 5transcriptional enhancer factor 5transcriptional enhancer factor TEF-5 (DTEF-1)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000433119, ENST00000295757, 
ENST00000402259, ENST00000402271, 
ENST00000446613, ENST00000404548, 
ENST00000404040, ENST00000405025, 
ENST00000522202, ENST00000437379, 
ENST00000495099, 		ENST00000402886, 
ENST00000338863, 
Fusion gene scores* DoF score6 X 5 X 5=1504 X 4 X 2=32
# samples 74
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HDAC11 [Title/Abstract] AND TEAD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHDAC11(13545627)-TEAD3(35445131), # samples:1
Anticipated loss of major functional domain due to fusion event.HDAC11-TEAD3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
HDAC11-TEAD3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
HDAC11-TEAD3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
HDAC11-TEAD3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
HDAC11-TEAD3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHDAC11

GO:0016575

histone deacetylation

11948178

TgeneTEAD3

GO:0035329

hippo signaling

18579750|19324877


check buttonFusion gene breakpoints across HDAC11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TEAD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE838173HDAC11chr3

13545627

-TEAD3chr6

35445131

+


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Fusion Gene ORF analysis for HDAC11-TEAD3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000433119ENST00000402886HDAC11chr3

13545627

-TEAD3chr6

35445131

+
In-frameENST00000433119ENST00000338863HDAC11chr3

13545627

-TEAD3chr6

35445131

+
Frame-shiftENST00000295757ENST00000402886HDAC11chr3

13545627

-TEAD3chr6

35445131

+
Frame-shiftENST00000295757ENST00000338863HDAC11chr3

13545627

-TEAD3chr6

35445131

+
Frame-shiftENST00000402259ENST00000402886HDAC11chr3

13545627

-TEAD3chr6

35445131

+
Frame-shiftENST00000402259ENST00000338863HDAC11chr3

13545627

-TEAD3chr6

35445131

+
Frame-shiftENST00000402271ENST00000402886HDAC11chr3

13545627

-TEAD3chr6

35445131

+
Frame-shiftENST00000402271ENST00000338863HDAC11chr3

13545627

-TEAD3chr6

35445131

+
Frame-shiftENST00000446613ENST00000402886HDAC11chr3

13545627

-TEAD3chr6

35445131

+
Frame-shiftENST00000446613ENST00000338863HDAC11chr3

13545627

-TEAD3chr6

35445131

+
In-frameENST00000404548ENST00000402886HDAC11chr3

13545627

-TEAD3chr6

35445131

+
In-frameENST00000404548ENST00000338863HDAC11chr3

13545627

-TEAD3chr6

35445131

+
Frame-shiftENST00000404040ENST00000402886HDAC11chr3

13545627

-TEAD3chr6

35445131

+
Frame-shiftENST00000404040ENST00000338863HDAC11chr3

13545627

-TEAD3chr6

35445131

+
In-frameENST00000405025ENST00000402886HDAC11chr3

13545627

-TEAD3chr6

35445131

+
In-frameENST00000405025ENST00000338863HDAC11chr3

13545627

-TEAD3chr6

35445131

+
Frame-shiftENST00000522202ENST00000402886HDAC11chr3

13545627

-TEAD3chr6

35445131

+
Frame-shiftENST00000522202ENST00000338863HDAC11chr3

13545627

-TEAD3chr6

35445131

+
Frame-shiftENST00000437379ENST00000402886HDAC11chr3

13545627

-TEAD3chr6

35445131

+
Frame-shiftENST00000437379ENST00000338863HDAC11chr3

13545627

-TEAD3chr6

35445131

+
intron-3CDSENST00000495099ENST00000402886HDAC11chr3

13545627

-TEAD3chr6

35445131

+
intron-3CDSENST00000495099ENST00000338863HDAC11chr3

13545627

-TEAD3chr6

35445131

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000433119HDAC11chr313545627-ENST00000402886TEAD3chr635445131+3349114219041245219
ENST00000433119HDAC11chr313545627-ENST00000338863TEAD3chr635445131+3349114219041245219
ENST00000404548HDAC11chr313545627-ENST00000402886TEAD3chr635445131+26284211183524219
ENST00000404548HDAC11chr313545627-ENST00000338863TEAD3chr635445131+26284211183524219
ENST00000405025HDAC11chr313545627-ENST00000402886TEAD3chr635445131+26734661228569219
ENST00000405025HDAC11chr313545627-ENST00000338863TEAD3chr635445131+26734661228569219

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000433119ENST00000402886HDAC11chr313545627-TEAD3chr635445131+0.343064070.65693593
ENST00000433119ENST00000338863HDAC11chr313545627-TEAD3chr635445131+0.343064070.65693593
ENST00000404548ENST00000402886HDAC11chr313545627-TEAD3chr635445131+0.86018170.1398183
ENST00000404548ENST00000338863HDAC11chr313545627-TEAD3chr635445131+0.86018170.1398183
ENST00000405025ENST00000402886HDAC11chr313545627-TEAD3chr635445131+0.615551530.38444844
ENST00000405025ENST00000338863HDAC11chr313545627-TEAD3chr635445131+0.615551530.38444844

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Fusion Genomic Features for HDAC11-TEAD3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HDAC11-TEAD3


check button Go to

FGviewer for the breakpoints of chr3:13545627-chr6:35445131

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTEAD3chr3:13545627chr6:35445131ENST00000338863013146_2130436.0Compositional biasNote=Pro-rich
TgeneTEAD3chr3:13545627chr6:35445131ENST0000033886301328_1040436.0DNA bindingTEA
TgeneTEAD3chr3:13545627chr6:35445131ENST00000338863013173_4350436.0RegionTranscriptional activation

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHDAC11chr3:13545627chr6:35445131ENST00000295757-11014_3260348.0RegionNote=Histone deacetylase
HgeneHDAC11chr3:13545627chr6:35445131ENST00000522202-11014_3260297.0RegionNote=Histone deacetylase


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Fusion Gene Sequence for HDAC11-TEAD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000433119_ENST00000402886_BE838173_HDAC11_chr3_13545627_-_TEAD3_chr6_35445131_length(transcript)=3349nt_BP=1142nt
GCAGGCTCTGAGAGCCTACATGTCTTCGCCGGGAGTGCTTGTCCCGGAGCTGCTCGCAGACTGGGCCGGGGGTGGGCTCGGGTCGGAGAG
GTCACGGGGCTCCTTAGGTCACAGGCGGCAGGGCCAGAGAAACTCCCCCGCCCCTACGTTTAACTCGCGGAAACAAGGGCCCAGAGAGCC
CAGACGCCAGCCCAAGGTCACACAGCGAAGCCCCGGCACAGCCCGCCGGGAACCTGTCGTTTCTAACCCCCAGCCTCTCGCCGTTTCTAC
CCAGCTTGGGAAGCGCAGGAACAGGACATACGGTGGTCGCGCCCCTTCCGCGAGGCCGGGGTGAAACCCGCTTGGCCCTCCCGCCAGGGG
GCGGAGCTTCCGAACCAGGCGGGATTCCACCGGGCTACACACAACCCAGCTGTACCAGCATGTGCCAGAGACACGCTGGCCAATCGTGTA
CTCGCCGCGCTACAACATCACCTTCATGGGCCTGGAGAAGCTGCATCCCTTTGATGCCGGAAAATGGGGCAAAGTGATCAATTTCCTAAA
AGAAGAGAAGCTTCTGTCTGACAGCATGCTGGTGGAGGCGCGGGAGGCCTCGGAGGAGGACCTGCTGGTGGTGCACACGAGGCGCTATCT
TAATGAGCTCAAGTGGTCCTTTGCTGTTGCTACCATCACAGAAATCCCCCCCGTTATCTTCCTCCCCAACTTCCTTGTGCAGAGGAAGGT
GCTGAGGCCCCTTCGGACCCAGACAGGAGGAACCATAATGGGGGTGGCTTCCACCACTGCTCCAGCGACCGTGGCGGGGGCTTCTGTGCC
TATGCGGACATCACGCTCGCCATCAAGTTTCTGTTTGAGCGTGTGGAGGGCATCTCCAGGGCTACCATCATTGATCTTGATGCCCATCAG
GGCAATGGGCATGAGCGAGACTTCATGGACGACAAGCGTGTGTACATCATGGATGTCTACAACCGCCACATCTACCCAGGGGACCGCTTT
GCCAAGCCACAGAGGATGATGAGTACCTGGATAAGGTGGAGAGGAACATCAAGAAATCCCTCCAGGAGCACCTGCCCGACGTGGTGGTAT
ACAATGCAGGCACCGACATCCTCGAGGGGGACCGCCTTGGGGGGCTGTCCATCAGCCCAGCGGTGGTCACGAGCCGGGACTCCCAGGAGA
CCCTGCTTGTCATTGCTTTTGTCTTCGAAGTCTCCACCAGTGAGCACGGGGCCCAGCACCATGTCTACAAGCTCGTCAAAGACTAGGGTG
CCCTCTGCGCCTCCTTAAGGATGCAGGGTGAGCATCTCCTCTCCACACCTGCCTGGCACCCCTGGGGGGGTCCAGGATTGAGGATTCATC
TACCTGCCAGGCCTCAGGCCCAGGACCCAGGAGGCCTCCCCACCTACCCCAGCACACACACTCCCTGCCACTGTTCTGCGCTTTAATTGT
GGGAGAAGAGAGGAGAGGAGGGCTCAGCGGTGGGGCAGCCTGTCCGGGGCGCTGACCCACCATCACCCTGCTCTGCCCAGCCTCGCGTGA
CCTCAGAGAGGTGGGGATAGGGGACACCTTCAGCCTCCAGCATGTGTGGCCACTGTACCCCCACCCACCCTTGGGGGAGCATGATGGGCA
GGTGAGGGCAGGATGGAGACCAAGGGAGTCAGTGAGCAGAGGCCCTGGGAGTGTCCGGTTGGGGTTGGACTGAGGACAGAGGGGCCCACA
CTTCCTTGCCCCTTTGTGTCCCAGGCCTGGTGCCCAGACTCCTTGCATGGCTTGTGTGGTCCTCAGACTCCGCACAGCGAGCGTAGGTCT
CTGGGTTTCAGATGAAGTGCCCAGGCTCCAGGAAGTTGAGGGACCCACAGGAGAGGTGGGCAGAGCTGGAGTTCTCATCCAGGGCTGCTT
GTCCCCAGAGCCCAGGTTTATACTACCTCCCTGGGGCGGGGGCTGGCCGCAGGGTAGGGGAGAGGCTCTGCAGTGTGGAGTGGAGCCTCA
TCGAGGGGCGCTGGGTTAGGGGAGCACCTGTTTCAGACTGGGCATGAAGAAGGGAGCACAGCAGCTACTAGACCCCATTAGCACCTCATT
AGCCCACAAGCCAGCCAGGGGCCCCAGGAAGATGGGGCACCCCCCAGCACCCTCCAGATTGAGAGCAAGGTAGAGGAAGGAGTCCCAGCC
TCTGGGCAGACCAGAGGCCCAGAGGGAGAGAGTAGCAGAAGGCTTTTGATTTTTCTCTTGCCTGAGGCTTGAATCTGACAAACCCTTGGT
GGGCACTGCTCCCTTAGGTTCTTCCCCACCTCAATCTACCTGCCTAGAGTAGCAGCTCCCAGACCCAGTTCTGGGACTGAAGGTTAACCC
TTCACCTGCTGTCCCTTCTTAACACCCAGGCCCCCAGAGCCAGCTGGGCCTGTCCAGCAGCCACCTGTGGGTATTTATGAGTTTCATATG
AAGTACTGTGCCCCTTCCCTTCCTCATCCCGACCCTGCCCGAGCTTCCTGAAGGTCCTCACTGTTTGCATATCGCTCAGGCCACCTCCAA
ACCCCACCTAGGTTTTATAATGTATATTATATATTTTTTTGTGTATTTTTAAAATCCAGCTGTGATGGGTTATATCATAAATGCAGCTTG
GGGTTGGAGCAGGGGCCCTCAAAGGCCCAGCTCCTGCTCAAAAAAAAAAAAAAAAAAAAATTAAAGTTATTTGTTTGTGGGTCAGTCATG
TAAACTGAGTATGCCAGGCTGGAGAACGGGCGCTTTGTGTACCGTATCCACCGCTCGCCCATGTGCGAGTACATGATCAACTTCATCCAC
AAGCTGAAGCACCTGCCCGAGAAGTACATGATGAACAGCGTGCTGGAGAACTTCACCATCCTGCAGGCCGACCTCAACAGCACCATCCAG
GAGGGCCCGGGAGCCTTCTATGGGGTCAGCTCTCAGTACAGCTCTGCTGATAGCATGACCATCAGCGTCTCCACCAAGGTGTGCTCCTTT
GGCAAACAGGTGGTAGAGAAGGTGGAGTACAGCAAACACCTGTTTGTGCACATCGGCCAGACGAACCCCGCCTTCTCAGACCCACCCCTG
GAGGCAGTAGATGTGCGCCAGATCTATGACAAATTCCCCGAGAAAAAGGGAGGATTGAAGGAGCTCTATGAGAAGGGGCCCCCTAATGCC
TTCTTCCTTGTCAAGTTCTGGGTTATGAGCCCCTGGCCCCGCTCCCCTCAGCTGCTGCCTCTGTGCCTGTGTGGCAGGACCGTACCATTG
CCTCCTCCCGGCTGCGGCTCCTGGAGTATTCAGCCTTCATGGAGGTGCAGCGAGACCCTGACACGGCCAGCCTACCCCATCCAGCCGCCC

>In-frame_ENST00000433119_ENST00000402886_BE838173_HDAC11_chr3_13545627_-_TEAD3_chr6_35445131_length(amino acids)=219AA_start in transcript=1904_stop in transcript=1245
MGSGDKQPWMRTPALPTSPVGPSTSWSLGTSSETQRPTLAVRSLRTTQAMQGVWAPGLGHKGARKCGPLCPQSNPNRTLPGPLLTDSLGL
HPALTCPSCSPKGGWGYSGHTCWRLKVSPIPTSLRSREAGQSRVMVGQRPGQAAPPLSPPLLSSPTIKAQNSGRECVCWGRWGGLLGPGP

--------------------------------------------------------------
>In-frame_ENST00000433119_ENST00000338863_BE838173_HDAC11_chr3_13545627_-_TEAD3_chr6_35445131_length(transcript)=3349nt_BP=1142nt
GCAGGCTCTGAGAGCCTACATGTCTTCGCCGGGAGTGCTTGTCCCGGAGCTGCTCGCAGACTGGGCCGGGGGTGGGCTCGGGTCGGAGAG
GTCACGGGGCTCCTTAGGTCACAGGCGGCAGGGCCAGAGAAACTCCCCCGCCCCTACGTTTAACTCGCGGAAACAAGGGCCCAGAGAGCC
CAGACGCCAGCCCAAGGTCACACAGCGAAGCCCCGGCACAGCCCGCCGGGAACCTGTCGTTTCTAACCCCCAGCCTCTCGCCGTTTCTAC
CCAGCTTGGGAAGCGCAGGAACAGGACATACGGTGGTCGCGCCCCTTCCGCGAGGCCGGGGTGAAACCCGCTTGGCCCTCCCGCCAGGGG
GCGGAGCTTCCGAACCAGGCGGGATTCCACCGGGCTACACACAACCCAGCTGTACCAGCATGTGCCAGAGACACGCTGGCCAATCGTGTA
CTCGCCGCGCTACAACATCACCTTCATGGGCCTGGAGAAGCTGCATCCCTTTGATGCCGGAAAATGGGGCAAAGTGATCAATTTCCTAAA
AGAAGAGAAGCTTCTGTCTGACAGCATGCTGGTGGAGGCGCGGGAGGCCTCGGAGGAGGACCTGCTGGTGGTGCACACGAGGCGCTATCT
TAATGAGCTCAAGTGGTCCTTTGCTGTTGCTACCATCACAGAAATCCCCCCCGTTATCTTCCTCCCCAACTTCCTTGTGCAGAGGAAGGT
GCTGAGGCCCCTTCGGACCCAGACAGGAGGAACCATAATGGGGGTGGCTTCCACCACTGCTCCAGCGACCGTGGCGGGGGCTTCTGTGCC
TATGCGGACATCACGCTCGCCATCAAGTTTCTGTTTGAGCGTGTGGAGGGCATCTCCAGGGCTACCATCATTGATCTTGATGCCCATCAG
GGCAATGGGCATGAGCGAGACTTCATGGACGACAAGCGTGTGTACATCATGGATGTCTACAACCGCCACATCTACCCAGGGGACCGCTTT
GCCAAGCCACAGAGGATGATGAGTACCTGGATAAGGTGGAGAGGAACATCAAGAAATCCCTCCAGGAGCACCTGCCCGACGTGGTGGTAT
ACAATGCAGGCACCGACATCCTCGAGGGGGACCGCCTTGGGGGGCTGTCCATCAGCCCAGCGGTGGTCACGAGCCGGGACTCCCAGGAGA
CCCTGCTTGTCATTGCTTTTGTCTTCGAAGTCTCCACCAGTGAGCACGGGGCCCAGCACCATGTCTACAAGCTCGTCAAAGACTAGGGTG
CCCTCTGCGCCTCCTTAAGGATGCAGGGTGAGCATCTCCTCTCCACACCTGCCTGGCACCCCTGGGGGGGTCCAGGATTGAGGATTCATC
TACCTGCCAGGCCTCAGGCCCAGGACCCAGGAGGCCTCCCCACCTACCCCAGCACACACACTCCCTGCCACTGTTCTGCGCTTTAATTGT
GGGAGAAGAGAGGAGAGGAGGGCTCAGCGGTGGGGCAGCCTGTCCGGGGCGCTGACCCACCATCACCCTGCTCTGCCCAGCCTCGCGTGA
CCTCAGAGAGGTGGGGATAGGGGACACCTTCAGCCTCCAGCATGTGTGGCCACTGTACCCCCACCCACCCTTGGGGGAGCATGATGGGCA
GGTGAGGGCAGGATGGAGACCAAGGGAGTCAGTGAGCAGAGGCCCTGGGAGTGTCCGGTTGGGGTTGGACTGAGGACAGAGGGGCCCACA
CTTCCTTGCCCCTTTGTGTCCCAGGCCTGGTGCCCAGACTCCTTGCATGGCTTGTGTGGTCCTCAGACTCCGCACAGCGAGCGTAGGTCT
CTGGGTTTCAGATGAAGTGCCCAGGCTCCAGGAAGTTGAGGGACCCACAGGAGAGGTGGGCAGAGCTGGAGTTCTCATCCAGGGCTGCTT
GTCCCCAGAGCCCAGGTTTATACTACCTCCCTGGGGCGGGGGCTGGCCGCAGGGTAGGGGAGAGGCTCTGCAGTGTGGAGTGGAGCCTCA
TCGAGGGGCGCTGGGTTAGGGGAGCACCTGTTTCAGACTGGGCATGAAGAAGGGAGCACAGCAGCTACTAGACCCCATTAGCACCTCATT
AGCCCACAAGCCAGCCAGGGGCCCCAGGAAGATGGGGCACCCCCCAGCACCCTCCAGATTGAGAGCAAGGTAGAGGAAGGAGTCCCAGCC
TCTGGGCAGACCAGAGGCCCAGAGGGAGAGAGTAGCAGAAGGCTTTTGATTTTTCTCTTGCCTGAGGCTTGAATCTGACAAACCCTTGGT
GGGCACTGCTCCCTTAGGTTCTTCCCCACCTCAATCTACCTGCCTAGAGTAGCAGCTCCCAGACCCAGTTCTGGGACTGAAGGTTAACCC
TTCACCTGCTGTCCCTTCTTAACACCCAGGCCCCCAGAGCCAGCTGGGCCTGTCCAGCAGCCACCTGTGGGTATTTATGAGTTTCATATG
AAGTACTGTGCCCCTTCCCTTCCTCATCCCGACCCTGCCCGAGCTTCCTGAAGGTCCTCACTGTTTGCATATCGCTCAGGCCACCTCCAA
ACCCCACCTAGGTTTTATAATGTATATTATATATTTTTTTGTGTATTTTTAAAATCCAGCTGTGATGGGTTATATCATAAATGCAGCTTG
GGGTTGGAGCAGGGGCCCTCAAAGGCCCAGCTCCTGCTCAAAAAAAAAAAAAAAAAAAAATTAAAGTTATTTGTTTGTGGGTCAGTCATG
TAAACTGAGTATGCCAGGCTGGAGAACGGGCGCTTTGTGTACCGTATCCACCGCTCGCCCATGTGCGAGTACATGATCAACTTCATCCAC
AAGCTGAAGCACCTGCCCGAGAAGTACATGATGAACAGCGTGCTGGAGAACTTCACCATCCTGCAGGCCGACCTCAACAGCACCATCCAG
GAGGGCCCGGGAGCCTTCTATGGGGTCAGCTCTCAGTACAGCTCTGCTGATAGCATGACCATCAGCGTCTCCACCAAGGTGTGCTCCTTT
GGCAAACAGGTGGTAGAGAAGGTGGAGTACAGCAAACACCTGTTTGTGCACATCGGCCAGACGAACCCCGCCTTCTCAGACCCACCCCTG
GAGGCAGTAGATGTGCGCCAGATCTATGACAAATTCCCCGAGAAAAAGGGAGGATTGAAGGAGCTCTATGAGAAGGGGCCCCCTAATGCC
TTCTTCCTTGTCAAGTTCTGGGTTATGAGCCCCTGGCCCCGCTCCCCTCAGCTGCTGCCTCTGTGCCTGTGTGGCAGGACCGTACCATTG
CCTCCTCCCGGCTGCGGCTCCTGGAGTATTCAGCCTTCATGGAGGTGCAGCGAGACCCTGACACGGCCAGCCTACCCCATCCAGCCGCCC

>In-frame_ENST00000433119_ENST00000338863_BE838173_HDAC11_chr3_13545627_-_TEAD3_chr6_35445131_length(amino acids)=219AA_start in transcript=1904_stop in transcript=1245
MGSGDKQPWMRTPALPTSPVGPSTSWSLGTSSETQRPTLAVRSLRTTQAMQGVWAPGLGHKGARKCGPLCPQSNPNRTLPGPLLTDSLGL
HPALTCPSCSPKGGWGYSGHTCWRLKVSPIPTSLRSREAGQSRVMVGQRPGQAAPPLSPPLLSSPTIKAQNSGRECVCWGRWGGLLGPGP

--------------------------------------------------------------
>In-frame_ENST00000404548_ENST00000402886_BE838173_HDAC11_chr3_13545627_-_TEAD3_chr6_35445131_length(transcript)=2628nt_BP=421nt
AGCTTTGGGAGGGCCGGCCCCGGGATGCTACACACAACCCAGCTGTACCAGCATGTGCCAGAGACACGCTGGCCAATCGTGTACTCGCCG
CGCTACAACATCACCTTCATGGGCCTGGAGAAGCTGCATCCCTTTGATGCCGGAAAATGGGGCAAAGTGATCAATTTCCTAAAAGAAGAG
AAGCTTCTGTCTGACAGCATGCTGGTGGAGGCGCGGGAGGCCTCGGAGGAGGACCTGCTGGTGGTGCACACGAGGCGCTATCTTAATGAG
CTCAAGCACAGAGGATGATGAGTACCTGGATAAGGTGGAGAGGAACATCAAGAAATCCCTCCAGGAGCACCTGCCCGACGTGGTGGTATA
CAATGCAGGCACCGACATCCTCGAGGGGGACCGCCTTGGGGGGCTGTCCATCAGCCCAGCGGTGGTCACGAGCCGGGACTCCCAGGAGAC
CCTGCTTGTCATTGCTTTTGTCTTCGAAGTCTCCACCAGTGAGCACGGGGCCCAGCACCATGTCTACAAGCTCGTCAAAGACTAGGGTGC
CCTCTGCGCCTCCTTAAGGATGCAGGGTGAGCATCTCCTCTCCACACCTGCCTGGCACCCCTGGGGGGGTCCAGGATTGAGGATTCATCT
ACCTGCCAGGCCTCAGGCCCAGGACCCAGGAGGCCTCCCCACCTACCCCAGCACACACACTCCCTGCCACTGTTCTGCGCTTTAATTGTG
GGAGAAGAGAGGAGAGGAGGGCTCAGCGGTGGGGCAGCCTGTCCGGGGCGCTGACCCACCATCACCCTGCTCTGCCCAGCCTCGCGTGAC
CTCAGAGAGGTGGGGATAGGGGACACCTTCAGCCTCCAGCATGTGTGGCCACTGTACCCCCACCCACCCTTGGGGGAGCATGATGGGCAG
GTGAGGGCAGGATGGAGACCAAGGGAGTCAGTGAGCAGAGGCCCTGGGAGTGTCCGGTTGGGGTTGGACTGAGGACAGAGGGGCCCACAC
TTCCTTGCCCCTTTGTGTCCCAGGCCTGGTGCCCAGACTCCTTGCATGGCTTGTGTGGTCCTCAGACTCCGCACAGCGAGCGTAGGTCTC
TGGGTTTCAGATGAAGTGCCCAGGCTCCAGGAAGTTGAGGGACCCACAGGAGAGGTGGGCAGAGCTGGAGTTCTCATCCAGGGCTGCTTG
TCCCCAGAGCCCAGGTTTATACTACCTCCCTGGGGCGGGGGCTGGCCGCAGGGTAGGGGAGAGGCTCTGCAGTGTGGAGTGGAGCCTCAT
CGAGGGGCGCTGGGTTAGGGGAGCACCTGTTTCAGACTGGGCATGAAGAAGGGAGCACAGCAGCTACTAGACCCCATTAGCACCTCATTA
GCCCACAAGCCAGCCAGGGGCCCCAGGAAGATGGGGCACCCCCCAGCACCCTCCAGATTGAGAGCAAGGTAGAGGAAGGAGTCCCAGCCT
CTGGGCAGACCAGAGGCCCAGAGGGAGAGAGTAGCAGAAGGCTTTTGATTTTTCTCTTGCCTGAGGCTTGAATCTGACAAACCCTTGGTG
GGCACTGCTCCCTTAGGTTCTTCCCCACCTCAATCTACCTGCCTAGAGTAGCAGCTCCCAGACCCAGTTCTGGGACTGAAGGTTAACCCT
TCACCTGCTGTCCCTTCTTAACACCCAGGCCCCCAGAGCCAGCTGGGCCTGTCCAGCAGCCACCTGTGGGTATTTATGAGTTTCATATGA
AGTACTGTGCCCCTTCCCTTCCTCATCCCGACCCTGCCCGAGCTTCCTGAAGGTCCTCACTGTTTGCATATCGCTCAGGCCACCTCCAAA
CCCCACCTAGGTTTTATAATGTATATTATATATTTTTTTGTGTATTTTTAAAATCCAGCTGTGATGGGTTATATCATAAATGCAGCTTGG
GGTTGGAGCAGGGGCCCTCAAAGGCCCAGCTCCTGCTCAAAAAAAAAAAAAAAAAAAAATTAAAGTTATTTGTTTGTGGGTCAGTCATGT
AAACTGAGTATGCCAGGCTGGAGAACGGGCGCTTTGTGTACCGTATCCACCGCTCGCCCATGTGCGAGTACATGATCAACTTCATCCACA
AGCTGAAGCACCTGCCCGAGAAGTACATGATGAACAGCGTGCTGGAGAACTTCACCATCCTGCAGGCCGACCTCAACAGCACCATCCAGG
AGGGCCCGGGAGCCTTCTATGGGGTCAGCTCTCAGTACAGCTCTGCTGATAGCATGACCATCAGCGTCTCCACCAAGGTGTGCTCCTTTG
GCAAACAGGTGGTAGAGAAGGTGGAGTACAGCAAACACCTGTTTGTGCACATCGGCCAGACGAACCCCGCCTTCTCAGACCCACCCCTGG
AGGCAGTAGATGTGCGCCAGATCTATGACAAATTCCCCGAGAAAAAGGGAGGATTGAAGGAGCTCTATGAGAAGGGGCCCCCTAATGCCT
TCTTCCTTGTCAAGTTCTGGGTTATGAGCCCCTGGCCCCGCTCCCCTCAGCTGCTGCCTCTGTGCCTGTGTGGCAGGACCGTACCATTGC
CTCCTCCCGGCTGCGGCTCCTGGAGTATTCAGCCTTCATGGAGGTGCAGCGAGACCCTGACACGGCCAGCCTACCCCATCCAGCCGCCCC

>In-frame_ENST00000404548_ENST00000402886_BE838173_HDAC11_chr3_13545627_-_TEAD3_chr6_35445131_length(amino acids)=219AA_start in transcript=1183_stop in transcript=524
MGSGDKQPWMRTPALPTSPVGPSTSWSLGTSSETQRPTLAVRSLRTTQAMQGVWAPGLGHKGARKCGPLCPQSNPNRTLPGPLLTDSLGL
HPALTCPSCSPKGGWGYSGHTCWRLKVSPIPTSLRSREAGQSRVMVGQRPGQAAPPLSPPLLSSPTIKAQNSGRECVCWGRWGGLLGPGP

--------------------------------------------------------------
>In-frame_ENST00000404548_ENST00000338863_BE838173_HDAC11_chr3_13545627_-_TEAD3_chr6_35445131_length(transcript)=2628nt_BP=421nt
AGCTTTGGGAGGGCCGGCCCCGGGATGCTACACACAACCCAGCTGTACCAGCATGTGCCAGAGACACGCTGGCCAATCGTGTACTCGCCG
CGCTACAACATCACCTTCATGGGCCTGGAGAAGCTGCATCCCTTTGATGCCGGAAAATGGGGCAAAGTGATCAATTTCCTAAAAGAAGAG
AAGCTTCTGTCTGACAGCATGCTGGTGGAGGCGCGGGAGGCCTCGGAGGAGGACCTGCTGGTGGTGCACACGAGGCGCTATCTTAATGAG
CTCAAGCACAGAGGATGATGAGTACCTGGATAAGGTGGAGAGGAACATCAAGAAATCCCTCCAGGAGCACCTGCCCGACGTGGTGGTATA
CAATGCAGGCACCGACATCCTCGAGGGGGACCGCCTTGGGGGGCTGTCCATCAGCCCAGCGGTGGTCACGAGCCGGGACTCCCAGGAGAC
CCTGCTTGTCATTGCTTTTGTCTTCGAAGTCTCCACCAGTGAGCACGGGGCCCAGCACCATGTCTACAAGCTCGTCAAAGACTAGGGTGC
CCTCTGCGCCTCCTTAAGGATGCAGGGTGAGCATCTCCTCTCCACACCTGCCTGGCACCCCTGGGGGGGTCCAGGATTGAGGATTCATCT
ACCTGCCAGGCCTCAGGCCCAGGACCCAGGAGGCCTCCCCACCTACCCCAGCACACACACTCCCTGCCACTGTTCTGCGCTTTAATTGTG
GGAGAAGAGAGGAGAGGAGGGCTCAGCGGTGGGGCAGCCTGTCCGGGGCGCTGACCCACCATCACCCTGCTCTGCCCAGCCTCGCGTGAC
CTCAGAGAGGTGGGGATAGGGGACACCTTCAGCCTCCAGCATGTGTGGCCACTGTACCCCCACCCACCCTTGGGGGAGCATGATGGGCAG
GTGAGGGCAGGATGGAGACCAAGGGAGTCAGTGAGCAGAGGCCCTGGGAGTGTCCGGTTGGGGTTGGACTGAGGACAGAGGGGCCCACAC
TTCCTTGCCCCTTTGTGTCCCAGGCCTGGTGCCCAGACTCCTTGCATGGCTTGTGTGGTCCTCAGACTCCGCACAGCGAGCGTAGGTCTC
TGGGTTTCAGATGAAGTGCCCAGGCTCCAGGAAGTTGAGGGACCCACAGGAGAGGTGGGCAGAGCTGGAGTTCTCATCCAGGGCTGCTTG
TCCCCAGAGCCCAGGTTTATACTACCTCCCTGGGGCGGGGGCTGGCCGCAGGGTAGGGGAGAGGCTCTGCAGTGTGGAGTGGAGCCTCAT
CGAGGGGCGCTGGGTTAGGGGAGCACCTGTTTCAGACTGGGCATGAAGAAGGGAGCACAGCAGCTACTAGACCCCATTAGCACCTCATTA
GCCCACAAGCCAGCCAGGGGCCCCAGGAAGATGGGGCACCCCCCAGCACCCTCCAGATTGAGAGCAAGGTAGAGGAAGGAGTCCCAGCCT
CTGGGCAGACCAGAGGCCCAGAGGGAGAGAGTAGCAGAAGGCTTTTGATTTTTCTCTTGCCTGAGGCTTGAATCTGACAAACCCTTGGTG
GGCACTGCTCCCTTAGGTTCTTCCCCACCTCAATCTACCTGCCTAGAGTAGCAGCTCCCAGACCCAGTTCTGGGACTGAAGGTTAACCCT
TCACCTGCTGTCCCTTCTTAACACCCAGGCCCCCAGAGCCAGCTGGGCCTGTCCAGCAGCCACCTGTGGGTATTTATGAGTTTCATATGA
AGTACTGTGCCCCTTCCCTTCCTCATCCCGACCCTGCCCGAGCTTCCTGAAGGTCCTCACTGTTTGCATATCGCTCAGGCCACCTCCAAA
CCCCACCTAGGTTTTATAATGTATATTATATATTTTTTTGTGTATTTTTAAAATCCAGCTGTGATGGGTTATATCATAAATGCAGCTTGG
GGTTGGAGCAGGGGCCCTCAAAGGCCCAGCTCCTGCTCAAAAAAAAAAAAAAAAAAAAATTAAAGTTATTTGTTTGTGGGTCAGTCATGT
AAACTGAGTATGCCAGGCTGGAGAACGGGCGCTTTGTGTACCGTATCCACCGCTCGCCCATGTGCGAGTACATGATCAACTTCATCCACA
AGCTGAAGCACCTGCCCGAGAAGTACATGATGAACAGCGTGCTGGAGAACTTCACCATCCTGCAGGCCGACCTCAACAGCACCATCCAGG
AGGGCCCGGGAGCCTTCTATGGGGTCAGCTCTCAGTACAGCTCTGCTGATAGCATGACCATCAGCGTCTCCACCAAGGTGTGCTCCTTTG
GCAAACAGGTGGTAGAGAAGGTGGAGTACAGCAAACACCTGTTTGTGCACATCGGCCAGACGAACCCCGCCTTCTCAGACCCACCCCTGG
AGGCAGTAGATGTGCGCCAGATCTATGACAAATTCCCCGAGAAAAAGGGAGGATTGAAGGAGCTCTATGAGAAGGGGCCCCCTAATGCCT
TCTTCCTTGTCAAGTTCTGGGTTATGAGCCCCTGGCCCCGCTCCCCTCAGCTGCTGCCTCTGTGCCTGTGTGGCAGGACCGTACCATTGC
CTCCTCCCGGCTGCGGCTCCTGGAGTATTCAGCCTTCATGGAGGTGCAGCGAGACCCTGACACGGCCAGCCTACCCCATCCAGCCGCCCC

>In-frame_ENST00000404548_ENST00000338863_BE838173_HDAC11_chr3_13545627_-_TEAD3_chr6_35445131_length(amino acids)=219AA_start in transcript=1183_stop in transcript=524
MGSGDKQPWMRTPALPTSPVGPSTSWSLGTSSETQRPTLAVRSLRTTQAMQGVWAPGLGHKGARKCGPLCPQSNPNRTLPGPLLTDSLGL
HPALTCPSCSPKGGWGYSGHTCWRLKVSPIPTSLRSREAGQSRVMVGQRPGQAAPPLSPPLLSSPTIKAQNSGRECVCWGRWGGLLGPGP

--------------------------------------------------------------
>In-frame_ENST00000405025_ENST00000402886_BE838173_HDAC11_chr3_13545627_-_TEAD3_chr6_35445131_length(transcript)=2673nt_BP=466nt
GTGGGCTCCCAGGGGTCCCGGTGGGCGGGCGCGCTAGGGCGAGGGCGGGGACGGCCGGGCGGGCGCGCCAGGCTACACACAACCCAGCTG
TACCAGCATGTGCCAGAGACACGCTGGCCAATCGTGTACTCGCCGCGCTACAACATCACCTTCATGGGCCTGGAGAAGCTGCATCCCTTT
GATGCCGGAAAATGGGGCAAAGTGATCAATTTCCTAAAAGAAGAGAAGCTTCTGTCTGACAGCATGCTGGTGGAGGCGCGGGAGGCCTCG
GAGGAGGACCTGCTGGTGGTGCACACGAGGCGCTATCTTAATGAGCTCAAGCACAGAGGATGATGAGTACCTGGATAAGGTGGAGAGGAA
CATCAAGAAATCCCTCCAGGAGCACCTGCCCGACGTGGTGGTATACAATGCAGGCACCGACATCCTCGAGGGGGACCGCCTTGGGGGGCT
GTCCATCAGCCCAGCGGTGGTCACGAGCCGGGACTCCCAGGAGACCCTGCTTGTCATTGCTTTTGTCTTCGAAGTCTCCACCAGTGAGCA
CGGGGCCCAGCACCATGTCTACAAGCTCGTCAAAGACTAGGGTGCCCTCTGCGCCTCCTTAAGGATGCAGGGTGAGCATCTCCTCTCCAC
ACCTGCCTGGCACCCCTGGGGGGGTCCAGGATTGAGGATTCATCTACCTGCCAGGCCTCAGGCCCAGGACCCAGGAGGCCTCCCCACCTA
CCCCAGCACACACACTCCCTGCCACTGTTCTGCGCTTTAATTGTGGGAGAAGAGAGGAGAGGAGGGCTCAGCGGTGGGGCAGCCTGTCCG
GGGCGCTGACCCACCATCACCCTGCTCTGCCCAGCCTCGCGTGACCTCAGAGAGGTGGGGATAGGGGACACCTTCAGCCTCCAGCATGTG
TGGCCACTGTACCCCCACCCACCCTTGGGGGAGCATGATGGGCAGGTGAGGGCAGGATGGAGACCAAGGGAGTCAGTGAGCAGAGGCCCT
GGGAGTGTCCGGTTGGGGTTGGACTGAGGACAGAGGGGCCCACACTTCCTTGCCCCTTTGTGTCCCAGGCCTGGTGCCCAGACTCCTTGC
ATGGCTTGTGTGGTCCTCAGACTCCGCACAGCGAGCGTAGGTCTCTGGGTTTCAGATGAAGTGCCCAGGCTCCAGGAAGTTGAGGGACCC
ACAGGAGAGGTGGGCAGAGCTGGAGTTCTCATCCAGGGCTGCTTGTCCCCAGAGCCCAGGTTTATACTACCTCCCTGGGGCGGGGGCTGG
CCGCAGGGTAGGGGAGAGGCTCTGCAGTGTGGAGTGGAGCCTCATCGAGGGGCGCTGGGTTAGGGGAGCACCTGTTTCAGACTGGGCATG
AAGAAGGGAGCACAGCAGCTACTAGACCCCATTAGCACCTCATTAGCCCACAAGCCAGCCAGGGGCCCCAGGAAGATGGGGCACCCCCCA
GCACCCTCCAGATTGAGAGCAAGGTAGAGGAAGGAGTCCCAGCCTCTGGGCAGACCAGAGGCCCAGAGGGAGAGAGTAGCAGAAGGCTTT
TGATTTTTCTCTTGCCTGAGGCTTGAATCTGACAAACCCTTGGTGGGCACTGCTCCCTTAGGTTCTTCCCCACCTCAATCTACCTGCCTA
GAGTAGCAGCTCCCAGACCCAGTTCTGGGACTGAAGGTTAACCCTTCACCTGCTGTCCCTTCTTAACACCCAGGCCCCCAGAGCCAGCTG
GGCCTGTCCAGCAGCCACCTGTGGGTATTTATGAGTTTCATATGAAGTACTGTGCCCCTTCCCTTCCTCATCCCGACCCTGCCCGAGCTT
CCTGAAGGTCCTCACTGTTTGCATATCGCTCAGGCCACCTCCAAACCCCACCTAGGTTTTATAATGTATATTATATATTTTTTTGTGTAT
TTTTAAAATCCAGCTGTGATGGGTTATATCATAAATGCAGCTTGGGGTTGGAGCAGGGGCCCTCAAAGGCCCAGCTCCTGCTCAAAAAAA
AAAAAAAAAAAAAATTAAAGTTATTTGTTTGTGGGTCAGTCATGTAAACTGAGTATGCCAGGCTGGAGAACGGGCGCTTTGTGTACCGTA
TCCACCGCTCGCCCATGTGCGAGTACATGATCAACTTCATCCACAAGCTGAAGCACCTGCCCGAGAAGTACATGATGAACAGCGTGCTGG
AGAACTTCACCATCCTGCAGGCCGACCTCAACAGCACCATCCAGGAGGGCCCGGGAGCCTTCTATGGGGTCAGCTCTCAGTACAGCTCTG
CTGATAGCATGACCATCAGCGTCTCCACCAAGGTGTGCTCCTTTGGCAAACAGGTGGTAGAGAAGGTGGAGTACAGCAAACACCTGTTTG
TGCACATCGGCCAGACGAACCCCGCCTTCTCAGACCCACCCCTGGAGGCAGTAGATGTGCGCCAGATCTATGACAAATTCCCCGAGAAAA
AGGGAGGATTGAAGGAGCTCTATGAGAAGGGGCCCCCTAATGCCTTCTTCCTTGTCAAGTTCTGGGTTATGAGCCCCTGGCCCCGCTCCC
CTCAGCTGCTGCCTCTGTGCCTGTGTGGCAGGACCGTACCATTGCCTCCTCCCGGCTGCGGCTCCTGGAGTATTCAGCCTTCATGGAGGT

>In-frame_ENST00000405025_ENST00000402886_BE838173_HDAC11_chr3_13545627_-_TEAD3_chr6_35445131_length(amino acids)=219AA_start in transcript=1228_stop in transcript=569
MGSGDKQPWMRTPALPTSPVGPSTSWSLGTSSETQRPTLAVRSLRTTQAMQGVWAPGLGHKGARKCGPLCPQSNPNRTLPGPLLTDSLGL
HPALTCPSCSPKGGWGYSGHTCWRLKVSPIPTSLRSREAGQSRVMVGQRPGQAAPPLSPPLLSSPTIKAQNSGRECVCWGRWGGLLGPGP

--------------------------------------------------------------
>In-frame_ENST00000405025_ENST00000338863_BE838173_HDAC11_chr3_13545627_-_TEAD3_chr6_35445131_length(transcript)=2673nt_BP=466nt
GTGGGCTCCCAGGGGTCCCGGTGGGCGGGCGCGCTAGGGCGAGGGCGGGGACGGCCGGGCGGGCGCGCCAGGCTACACACAACCCAGCTG
TACCAGCATGTGCCAGAGACACGCTGGCCAATCGTGTACTCGCCGCGCTACAACATCACCTTCATGGGCCTGGAGAAGCTGCATCCCTTT
GATGCCGGAAAATGGGGCAAAGTGATCAATTTCCTAAAAGAAGAGAAGCTTCTGTCTGACAGCATGCTGGTGGAGGCGCGGGAGGCCTCG
GAGGAGGACCTGCTGGTGGTGCACACGAGGCGCTATCTTAATGAGCTCAAGCACAGAGGATGATGAGTACCTGGATAAGGTGGAGAGGAA
CATCAAGAAATCCCTCCAGGAGCACCTGCCCGACGTGGTGGTATACAATGCAGGCACCGACATCCTCGAGGGGGACCGCCTTGGGGGGCT
GTCCATCAGCCCAGCGGTGGTCACGAGCCGGGACTCCCAGGAGACCCTGCTTGTCATTGCTTTTGTCTTCGAAGTCTCCACCAGTGAGCA
CGGGGCCCAGCACCATGTCTACAAGCTCGTCAAAGACTAGGGTGCCCTCTGCGCCTCCTTAAGGATGCAGGGTGAGCATCTCCTCTCCAC
ACCTGCCTGGCACCCCTGGGGGGGTCCAGGATTGAGGATTCATCTACCTGCCAGGCCTCAGGCCCAGGACCCAGGAGGCCTCCCCACCTA
CCCCAGCACACACACTCCCTGCCACTGTTCTGCGCTTTAATTGTGGGAGAAGAGAGGAGAGGAGGGCTCAGCGGTGGGGCAGCCTGTCCG
GGGCGCTGACCCACCATCACCCTGCTCTGCCCAGCCTCGCGTGACCTCAGAGAGGTGGGGATAGGGGACACCTTCAGCCTCCAGCATGTG
TGGCCACTGTACCCCCACCCACCCTTGGGGGAGCATGATGGGCAGGTGAGGGCAGGATGGAGACCAAGGGAGTCAGTGAGCAGAGGCCCT
GGGAGTGTCCGGTTGGGGTTGGACTGAGGACAGAGGGGCCCACACTTCCTTGCCCCTTTGTGTCCCAGGCCTGGTGCCCAGACTCCTTGC
ATGGCTTGTGTGGTCCTCAGACTCCGCACAGCGAGCGTAGGTCTCTGGGTTTCAGATGAAGTGCCCAGGCTCCAGGAAGTTGAGGGACCC
ACAGGAGAGGTGGGCAGAGCTGGAGTTCTCATCCAGGGCTGCTTGTCCCCAGAGCCCAGGTTTATACTACCTCCCTGGGGCGGGGGCTGG
CCGCAGGGTAGGGGAGAGGCTCTGCAGTGTGGAGTGGAGCCTCATCGAGGGGCGCTGGGTTAGGGGAGCACCTGTTTCAGACTGGGCATG
AAGAAGGGAGCACAGCAGCTACTAGACCCCATTAGCACCTCATTAGCCCACAAGCCAGCCAGGGGCCCCAGGAAGATGGGGCACCCCCCA
GCACCCTCCAGATTGAGAGCAAGGTAGAGGAAGGAGTCCCAGCCTCTGGGCAGACCAGAGGCCCAGAGGGAGAGAGTAGCAGAAGGCTTT
TGATTTTTCTCTTGCCTGAGGCTTGAATCTGACAAACCCTTGGTGGGCACTGCTCCCTTAGGTTCTTCCCCACCTCAATCTACCTGCCTA
GAGTAGCAGCTCCCAGACCCAGTTCTGGGACTGAAGGTTAACCCTTCACCTGCTGTCCCTTCTTAACACCCAGGCCCCCAGAGCCAGCTG
GGCCTGTCCAGCAGCCACCTGTGGGTATTTATGAGTTTCATATGAAGTACTGTGCCCCTTCCCTTCCTCATCCCGACCCTGCCCGAGCTT
CCTGAAGGTCCTCACTGTTTGCATATCGCTCAGGCCACCTCCAAACCCCACCTAGGTTTTATAATGTATATTATATATTTTTTTGTGTAT
TTTTAAAATCCAGCTGTGATGGGTTATATCATAAATGCAGCTTGGGGTTGGAGCAGGGGCCCTCAAAGGCCCAGCTCCTGCTCAAAAAAA
AAAAAAAAAAAAAATTAAAGTTATTTGTTTGTGGGTCAGTCATGTAAACTGAGTATGCCAGGCTGGAGAACGGGCGCTTTGTGTACCGTA
TCCACCGCTCGCCCATGTGCGAGTACATGATCAACTTCATCCACAAGCTGAAGCACCTGCCCGAGAAGTACATGATGAACAGCGTGCTGG
AGAACTTCACCATCCTGCAGGCCGACCTCAACAGCACCATCCAGGAGGGCCCGGGAGCCTTCTATGGGGTCAGCTCTCAGTACAGCTCTG
CTGATAGCATGACCATCAGCGTCTCCACCAAGGTGTGCTCCTTTGGCAAACAGGTGGTAGAGAAGGTGGAGTACAGCAAACACCTGTTTG
TGCACATCGGCCAGACGAACCCCGCCTTCTCAGACCCACCCCTGGAGGCAGTAGATGTGCGCCAGATCTATGACAAATTCCCCGAGAAAA
AGGGAGGATTGAAGGAGCTCTATGAGAAGGGGCCCCCTAATGCCTTCTTCCTTGTCAAGTTCTGGGTTATGAGCCCCTGGCCCCGCTCCC
CTCAGCTGCTGCCTCTGTGCCTGTGTGGCAGGACCGTACCATTGCCTCCTCCCGGCTGCGGCTCCTGGAGTATTCAGCCTTCATGGAGGT

>In-frame_ENST00000405025_ENST00000338863_BE838173_HDAC11_chr3_13545627_-_TEAD3_chr6_35445131_length(amino acids)=219AA_start in transcript=1228_stop in transcript=569
MGSGDKQPWMRTPALPTSPVGPSTSWSLGTSSETQRPTLAVRSLRTTQAMQGVWAPGLGHKGARKCGPLCPQSNPNRTLPGPLLTDSLGL
HPALTCPSCSPKGGWGYSGHTCWRLKVSPIPTSLRSREAGQSRVMVGQRPGQAAPPLSPPLLSSPTIKAQNSGRECVCWGRWGGLLGPGP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HDAC11-TEAD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HDAC11-TEAD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HDAC11-TEAD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource