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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HDDC2-TPD52L1 (FusionGDB2 ID:35760)

Fusion Gene Summary for HDDC2-TPD52L1

check button Fusion gene summary
Fusion gene informationFusion gene name: HDDC2-TPD52L1
Fusion gene ID: 35760
HgeneTgene
Gene symbol

HDDC2

TPD52L1

Gene ID

51020

7164

Gene nameHD domain containing 2TPD52 like 1
SynonymsC6orf74|CGI-130|NS5ATP2|dJ167O5.2D53|TPD53
Cytomap

6q22.31

6q22.31

Type of geneprotein-codingprotein-coding
DescriptionHD domain-containing protein 2HCV NS5A-transactivated protein 2hepatitis C virus NS5A-transactivated protein 2testicular tissue protein Li 83tumor protein D53tumor protein D52 like 1
Modification date2020031320200327
UniProtAcc

Q7Z4H3

.
Ensembl transtripts involved in fusion geneENST00000608456, ENST00000368377, 
ENST00000608295, ENST00000398153, 
ENST00000608284, 		ENST00000304877, 
ENST00000534000, ENST00000368402, 
ENST00000368388, ENST00000527711, 
ENST00000528193, ENST00000532429, 
ENST00000534199, ENST00000392482, 
ENST00000524679, ENST00000530868, 
Fusion gene scores* DoF score4 X 6 X 3=728 X 8 X 6=384
# samples 512
** MAII scorelog2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/384*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HDDC2 [Title/Abstract] AND TPD52L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHDDC2(125621683)-TPD52L1(125583979), # samples:1
HDDC2(125621684)-TPD52L1(125583980), # samples:1
HDDC2(125619860)-TPD52L1(125583980), # samples:1
TPD52L1(125475116)-HDDC2(125614055), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTPD52L1

GO:0000086

G2/M transition of mitotic cell cycle

16112108

TgeneTPD52L1

GO:0043406

positive regulation of MAP kinase activity

14761963

TgeneTPD52L1

GO:0046330

positive regulation of JNK cascade

14761963

TgeneTPD52L1

GO:2001235

positive regulation of apoptotic signaling pathway

14761963


check buttonFusion gene breakpoints across HDDC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TPD52L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-A1A7HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
ChimerDB4BLCATCGA-DK-A1A7-01AHDDC2chr6

125621684

-TPD52L1chr6

125583980

+
ChimerDB4BLCATCGA-DK-A1A7-01AHDDC2chr6

125619860

-TPD52L1chr6

125583980

+


Top

Fusion Gene ORF analysis for HDDC2-TPD52L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000608456ENST00000304877HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
intron-3CDSENST00000608456ENST00000534000HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
intron-3CDSENST00000608456ENST00000368402HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
intron-3CDSENST00000608456ENST00000368388HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
intron-3CDSENST00000608456ENST00000527711HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
intron-3UTRENST00000608456ENST00000528193HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
intron-3UTRENST00000608456ENST00000532429HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
intron-3UTRENST00000608456ENST00000534199HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
intron-3UTRENST00000608456ENST00000392482HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
intron-3UTRENST00000608456ENST00000524679HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
intron-3UTRENST00000608456ENST00000530868HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
In-frameENST00000368377ENST00000304877HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
Frame-shiftENST00000368377ENST00000534000HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
Frame-shiftENST00000368377ENST00000368402HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
In-frameENST00000368377ENST00000368388HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
Frame-shiftENST00000368377ENST00000527711HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000368377ENST00000528193HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000368377ENST00000532429HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000368377ENST00000534199HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000368377ENST00000392482HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000368377ENST00000524679HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000368377ENST00000530868HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
Frame-shiftENST00000608295ENST00000304877HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
Frame-shiftENST00000608295ENST00000534000HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
In-frameENST00000608295ENST00000368402HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
Frame-shiftENST00000608295ENST00000368388HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
In-frameENST00000608295ENST00000527711HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000608295ENST00000528193HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000608295ENST00000532429HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000608295ENST00000534199HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000608295ENST00000392482HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000608295ENST00000524679HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000608295ENST00000530868HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
In-frameENST00000398153ENST00000304877HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
Frame-shiftENST00000398153ENST00000534000HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
Frame-shiftENST00000398153ENST00000368402HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
In-frameENST00000398153ENST00000368388HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
Frame-shiftENST00000398153ENST00000527711HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000398153ENST00000528193HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000398153ENST00000532429HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000398153ENST00000534199HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000398153ENST00000392482HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000398153ENST00000524679HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000398153ENST00000530868HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
In-frameENST00000608284ENST00000304877HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
Frame-shiftENST00000608284ENST00000534000HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
Frame-shiftENST00000608284ENST00000368402HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
In-frameENST00000608284ENST00000368388HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
Frame-shiftENST00000608284ENST00000527711HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000608284ENST00000528193HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000608284ENST00000532429HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000608284ENST00000534199HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000608284ENST00000392482HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000608284ENST00000524679HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
5CDS-3UTRENST00000608284ENST00000530868HDDC2chr6

125621683

-TPD52L1chr6

125583979

+
intron-3CDSENST00000608456ENST00000304877HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
intron-3CDSENST00000608456ENST00000534000HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
intron-3CDSENST00000608456ENST00000368402HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
intron-3CDSENST00000608456ENST00000368388HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
intron-3CDSENST00000608456ENST00000527711HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608456ENST00000528193HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608456ENST00000532429HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608456ENST00000534199HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608456ENST00000392482HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608456ENST00000524679HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608456ENST00000530868HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
In-frameENST00000368377ENST00000304877HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
Frame-shiftENST00000368377ENST00000534000HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
Frame-shiftENST00000368377ENST00000368402HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
In-frameENST00000368377ENST00000368388HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
Frame-shiftENST00000368377ENST00000527711HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000368377ENST00000528193HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000368377ENST00000532429HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000368377ENST00000534199HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000368377ENST00000392482HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000368377ENST00000524679HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000368377ENST00000530868HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
Frame-shiftENST00000608295ENST00000304877HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
Frame-shiftENST00000608295ENST00000534000HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
In-frameENST00000608295ENST00000368402HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
Frame-shiftENST00000608295ENST00000368388HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
In-frameENST00000608295ENST00000527711HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608295ENST00000528193HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608295ENST00000532429HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608295ENST00000534199HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608295ENST00000392482HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608295ENST00000524679HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608295ENST00000530868HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
In-frameENST00000398153ENST00000304877HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
Frame-shiftENST00000398153ENST00000534000HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
Frame-shiftENST00000398153ENST00000368402HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
In-frameENST00000398153ENST00000368388HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
Frame-shiftENST00000398153ENST00000527711HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000398153ENST00000528193HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000398153ENST00000532429HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000398153ENST00000534199HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000398153ENST00000392482HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000398153ENST00000524679HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000398153ENST00000530868HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
In-frameENST00000608284ENST00000304877HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
Frame-shiftENST00000608284ENST00000534000HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
Frame-shiftENST00000608284ENST00000368402HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
In-frameENST00000608284ENST00000368388HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
Frame-shiftENST00000608284ENST00000527711HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608284ENST00000528193HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608284ENST00000532429HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608284ENST00000534199HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608284ENST00000392482HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608284ENST00000524679HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608284ENST00000530868HDDC2chr6

125621684

-TPD52L1chr6

125583980

+
intron-3CDSENST00000608456ENST00000304877HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3CDSENST00000608456ENST00000534000HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3CDSENST00000608456ENST00000368402HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3CDSENST00000608456ENST00000368388HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3CDSENST00000608456ENST00000527711HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608456ENST00000528193HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608456ENST00000532429HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608456ENST00000534199HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608456ENST00000392482HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608456ENST00000524679HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608456ENST00000530868HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3CDSENST00000368377ENST00000304877HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3CDSENST00000368377ENST00000534000HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3CDSENST00000368377ENST00000368402HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3CDSENST00000368377ENST00000368388HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3CDSENST00000368377ENST00000527711HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000368377ENST00000528193HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000368377ENST00000532429HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000368377ENST00000534199HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000368377ENST00000392482HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000368377ENST00000524679HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000368377ENST00000530868HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3CDSENST00000608295ENST00000304877HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3CDSENST00000608295ENST00000534000HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3CDSENST00000608295ENST00000368402HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3CDSENST00000608295ENST00000368388HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3CDSENST00000608295ENST00000527711HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608295ENST00000528193HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608295ENST00000532429HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608295ENST00000534199HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608295ENST00000392482HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608295ENST00000524679HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
intron-3UTRENST00000608295ENST00000530868HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
Frame-shiftENST00000398153ENST00000304877HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
Frame-shiftENST00000398153ENST00000534000HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
In-frameENST00000398153ENST00000368402HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
Frame-shiftENST00000398153ENST00000368388HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
In-frameENST00000398153ENST00000527711HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000398153ENST00000528193HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000398153ENST00000532429HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000398153ENST00000534199HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000398153ENST00000392482HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000398153ENST00000524679HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000398153ENST00000530868HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
Frame-shiftENST00000608284ENST00000304877HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
Frame-shiftENST00000608284ENST00000534000HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
In-frameENST00000608284ENST00000368402HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
Frame-shiftENST00000608284ENST00000368388HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
In-frameENST00000608284ENST00000527711HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608284ENST00000528193HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608284ENST00000532429HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608284ENST00000534199HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608284ENST00000392482HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608284ENST00000524679HDDC2chr6

125619860

-TPD52L1chr6

125583980

+
5CDS-3UTRENST00000608284ENST00000530868HDDC2chr6

125619860

-TPD52L1chr6

125583980

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for HDDC2-TPD52L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HDDC2chr6125621683-TPD52L1chr6125583979+0.0011806090.9988194
HDDC2chr6125621683-TPD52L1chr6125583979+0.0011806090.9988194
HDDC2chr6125619859-TPD52L1chr6125583979+0.0008370330.99916303
HDDC2chr6125621683-TPD52L1chr6125583979+0.0011806090.9988194
HDDC2chr6125621683-TPD52L1chr6125583979+0.0011806090.9988194
HDDC2chr6125619859-TPD52L1chr6125583979+0.0008370330.99916303

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HDDC2-TPD52L1


check button Go to

FGviewer for the breakpoints of chr6:125621683-chr6:125583979

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HDDC2

Q7Z4H3

.
FUNCTION: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP). {ECO:0000250|UniProtKB:P53144}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHDDC2chr6:125619860chr6:125583980ENST00000368377-1646_1480171.0DomainHD
HgeneHDDC2chr6:125619860chr6:125583980ENST00000398153-3646_148103.0205.0DomainHD
HgeneHDDC2chr6:125621683chr6:125583979ENST00000368377-2646_14868.66666666666667171.0DomainHD
HgeneHDDC2chr6:125621683chr6:125583979ENST00000398153-2646_14868.66666666666667205.0DomainHD
HgeneHDDC2chr6:125621684chr6:125583980ENST00000368377-2646_14868.66666666666667171.0DomainHD
HgeneHDDC2chr6:125621684chr6:125583980ENST00000398153-2646_14868.66666666666667205.0DomainHD
TgeneTPD52L1chr6:125619860chr6:125583980ENST000003683883522_73128.66666666666666132.0Coiled coilOntology_term=ECO:0000255
TgeneTPD52L1chr6:125619860chr6:125583980ENST000003684024622_73141.66666666666666145.0Coiled coilOntology_term=ECO:0000255
TgeneTPD52L1chr6:125619860chr6:125583980ENST000003924823522_7399.66666666666667103.0Coiled coilOntology_term=ECO:0000255
TgeneTPD52L1chr6:125619860chr6:125583980ENST000005246792422_7399.66666666666667103.0Coiled coilOntology_term=ECO:0000255
TgeneTPD52L1chr6:125619860chr6:125583980ENST000005340005722_73162.0205.0Coiled coilOntology_term=ECO:0000255
TgeneTPD52L1chr6:125619860chr6:125583980ENST000005341993522_7399.66666666666667103.0Coiled coilOntology_term=ECO:0000255
TgeneTPD52L1chr6:125621683chr6:125583979ENST000003683883522_73128.66666666666666132.0Coiled coilOntology_term=ECO:0000255
TgeneTPD52L1chr6:125621683chr6:125583979ENST000003684024622_73141.66666666666666145.0Coiled coilOntology_term=ECO:0000255
TgeneTPD52L1chr6:125621683chr6:125583979ENST000003924823522_7399.66666666666667103.0Coiled coilOntology_term=ECO:0000255
TgeneTPD52L1chr6:125621683chr6:125583979ENST000005246792422_7399.66666666666667103.0Coiled coilOntology_term=ECO:0000255
TgeneTPD52L1chr6:125621683chr6:125583979ENST000005340005722_73162.0205.0Coiled coilOntology_term=ECO:0000255
TgeneTPD52L1chr6:125621683chr6:125583979ENST000005341993522_7399.66666666666667103.0Coiled coilOntology_term=ECO:0000255
TgeneTPD52L1chr6:125621684chr6:125583980ENST000003683883522_73128.66666666666666132.0Coiled coilOntology_term=ECO:0000255
TgeneTPD52L1chr6:125621684chr6:125583980ENST000003684024622_73141.66666666666666145.0Coiled coilOntology_term=ECO:0000255
TgeneTPD52L1chr6:125621684chr6:125583980ENST000003924823522_7399.66666666666667103.0Coiled coilOntology_term=ECO:0000255
TgeneTPD52L1chr6:125621684chr6:125583980ENST000005246792422_7399.66666666666667103.0Coiled coilOntology_term=ECO:0000255
TgeneTPD52L1chr6:125621684chr6:125583980ENST000005340005722_73162.0205.0Coiled coilOntology_term=ECO:0000255
TgeneTPD52L1chr6:125621684chr6:125583980ENST000005341993522_7399.66666666666667103.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for HDDC2-TPD52L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HDDC2-TPD52L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HDDC2-TPD52L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HDDC2-TPD52L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTPD52L1C0033578Prostatic Neoplasms1CTD_human
TgeneTPD52L1C0376358Malignant neoplasm of prostate1CTD_human