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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HERC3-CISD2 (FusionGDB2 ID:36038)

Fusion Gene Summary for HERC3-CISD2

Fusion gene summary

Fusion gene information	Fusion gene name: HERC3-CISD2
	Fusion gene ID: 36038
		Hgene	Tgene
	Gene symbol	HERC3	CISD2
	Gene ID	8916	493856
	Gene name	HECT and RLD domain containing E3 ubiquitin protein ligase 3	CDGSH iron sulfur domain 2
	Synonyms	-	ERIS\|Miner1\|NAF-1\|WFS2\|ZCD2
	Cytomap	4q22.1	4q24
	Type of gene	protein-coding	protein-coding
	Description	probable E3 ubiquitin-protein ligase HERC3HECT domain and RCC1-like domain-containing protein 3HECT-type E3 ubiquitin transferase HERC3hect domain and RLD 3	CDGSH iron-sulfur domain-containing protein 2endoplasmic reticulum intermembrane small proteinmitoNEET-related 1 proteinnutrient-deprivation autophagy factor-1zinc finger, CDGSH-type domain 2
	Modification date	20200313	20200313
	UniProtAcc	Q15034	Q8N5K1
	Ensembl transtripts involved in fusion gene	ENST00000402738, ENST00000407637, ENST00000601319, ENST00000264345, ENST00000543130,	ENST00000273986, ENST00000503643,
Fusion gene scores	* DoF score	4 X 3 X 4=48	4 X 4 X 4=64
	# samples	4	6
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/64*10)=-0.0931094043914815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HERC3 [Title/Abstract] AND CISD2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HERC3(89527200)-CISD2(103806373), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across HERC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CISD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8295-01A	HERC3	chr4	89527200	+	CISD2	chr4	103806373	+

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Fusion Gene ORF analysis for HERC3-CISD2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000402738	ENST00000273986	HERC3	chr4	89527200	+	CISD2	chr4	103806373	+
In-frame	ENST00000402738	ENST00000503643	HERC3	chr4	89527200	+	CISD2	chr4	103806373	+
In-frame	ENST00000407637	ENST00000273986	HERC3	chr4	89527200	+	CISD2	chr4	103806373	+
In-frame	ENST00000407637	ENST00000503643	HERC3	chr4	89527200	+	CISD2	chr4	103806373	+
intron-3CDS	ENST00000601319	ENST00000273986	HERC3	chr4	89527200	+	CISD2	chr4	103806373	+
intron-3CDS	ENST00000601319	ENST00000503643	HERC3	chr4	89527200	+	CISD2	chr4	103806373	+
In-frame	ENST00000264345	ENST00000273986	HERC3	chr4	89527200	+	CISD2	chr4	103806373	+
In-frame	ENST00000264345	ENST00000503643	HERC3	chr4	89527200	+	CISD2	chr4	103806373	+
intron-3CDS	ENST00000543130	ENST00000273986	HERC3	chr4	89527200	+	CISD2	chr4	103806373	+
intron-3CDS	ENST00000543130	ENST00000503643	HERC3	chr4	89527200	+	CISD2	chr4	103806373	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000402738	HERC3	chr4	89527200	+	ENST00000273986	CISD2	chr4	103806373	+	2582	465	239	769	176
ENST00000402738	HERC3	chr4	89527200	+	ENST00000503643	CISD2	chr4	103806373	+	1096	465	239	769	176
ENST00000407637	HERC3	chr4	89527200	+	ENST00000273986	CISD2	chr4	103806373	+	2509	392	166	696	176
ENST00000407637	HERC3	chr4	89527200	+	ENST00000503643	CISD2	chr4	103806373	+	1023	392	166	696	176
ENST00000264345	HERC3	chr4	89527200	+	ENST00000273986	CISD2	chr4	103806373	+	2373	256	30	560	176
ENST00000264345	HERC3	chr4	89527200	+	ENST00000503643	CISD2	chr4	103806373	+	887	256	30	560	176

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000402738	ENST00000273986	HERC3	chr4	89527200	+	CISD2	chr4	103806373	+	0.003941754	0.9960582
ENST00000402738	ENST00000503643	HERC3	chr4	89527200	+	CISD2	chr4	103806373	+	0.005184521	0.9948154
ENST00000407637	ENST00000273986	HERC3	chr4	89527200	+	CISD2	chr4	103806373	+	0.005830415	0.9941696
ENST00000407637	ENST00000503643	HERC3	chr4	89527200	+	CISD2	chr4	103806373	+	0.007688935	0.9923111
ENST00000264345	ENST00000273986	HERC3	chr4	89527200	+	CISD2	chr4	103806373	+	0.003892208	0.99610776
ENST00000264345	ENST00000503643	HERC3	chr4	89527200	+	CISD2	chr4	103806373	+	0.004948491	0.99505156

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Fusion Genomic Features for HERC3-CISD2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
HERC3	chr4	89527200	+	CISD2	chr4	103806372	+	1.66E-06	0.99999833
HERC3	chr4	89527200	+	CISD2	chr4	103806372	+	1.66E-06	0.99999833

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HERC3-CISD2

Go to
FGviewer for the breakpoints of chr4:89527200-chr4:103806373
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HERC3 Q15034	CISD2 Q8N5K1
FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}.	FUNCTION: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. {ECO:0000269\|PubMed:17846994, ECO:0000269\|PubMed:20010695}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HERC3

chr4:89527200

chr4:103806373

ENST00000264345

1_51

75.33333333333333

1051.0

Repeat

Note=RCC1 1

Hgene

HERC3

chr4:89527200

chr4:103806373

ENST00000402738

1_51

75.33333333333333

1051.0

Repeat

Note=RCC1 1

Tgene

CISD2

chr4:89527200

chr4:103806373

ENST00000273986

61_135

34.333333333333336

136.0

Topological domain

Cytoplasmic

Tgene

CISD2

chr4:89527200

chr4:103806373

ENST00000273986

38_60

34.333333333333336

136.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HERC3

chr4:89527200

chr4:103806373

ENST00000264345

951_1050

75.33333333333333

1051.0

Domain

HECT

Hgene

HERC3

chr4:89527200

chr4:103806373

ENST00000402738

951_1050

75.33333333333333

1051.0

Domain

HECT

Hgene

HERC3

chr4:89527200

chr4:103806373

ENST00000264345

102_154

75.33333333333333

1051.0

Repeat

Note=RCC1 3

Hgene

HERC3

chr4:89527200

chr4:103806373

ENST00000264345

156_207

75.33333333333333

1051.0

Repeat

Note=RCC1 4

Hgene

HERC3

chr4:89527200

chr4:103806373

ENST00000264345

208_259

75.33333333333333

1051.0

Repeat

Note=RCC1 5

Hgene

HERC3

chr4:89527200

chr4:103806373

ENST00000264345

261_311

75.33333333333333

1051.0

Repeat

Note=RCC1 6

Hgene

HERC3

chr4:89527200

chr4:103806373

ENST00000264345

313_366

75.33333333333333

1051.0

Repeat

Note=RCC1 7

Hgene

HERC3

chr4:89527200

chr4:103806373

ENST00000264345

52_101

75.33333333333333

1051.0

Repeat

Note=RCC1 2

Hgene

HERC3

chr4:89527200

chr4:103806373

ENST00000402738

102_154

75.33333333333333

1051.0

Repeat

Note=RCC1 3

Hgene

HERC3

chr4:89527200

chr4:103806373

ENST00000402738

156_207

75.33333333333333

1051.0

Repeat

Note=RCC1 4

Hgene

HERC3

chr4:89527200

chr4:103806373

ENST00000402738

208_259

75.33333333333333

1051.0

Repeat

Note=RCC1 5

Hgene

HERC3

chr4:89527200

chr4:103806373

ENST00000402738

261_311

75.33333333333333

1051.0

Repeat

Note=RCC1 6

Hgene

HERC3

chr4:89527200

chr4:103806373

ENST00000402738

313_366

75.33333333333333

1051.0

Repeat

Note=RCC1 7

Hgene

HERC3

chr4:89527200

chr4:103806373

ENST00000402738

52_101

75.33333333333333

1051.0

Repeat

Note=RCC1 2

Tgene

CISD2

chr4:89527200

chr4:103806373

ENST00000273986

2_37

34.333333333333336

136.0

Topological domain

Lumenal

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Fusion Gene Sequence for HERC3-CISD2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000402738_ENST00000273986_TCGA-BR-8295-01A_HERC3_chr4_89527200_+_CISD2_chr4_103806373_length(transcript)=2582nt_BP=465nt
GGTGCGAAGCCATTCACCCAGCGCATTCCGCCGCCCGCAGGCTTGCGGGGAAACTTCCTTATTATTGTGACGCCGAAAACGGAGAAACCC
CGGGTCCGGCGAGAGGGGCTGTGACAGTCGGAGTCCCAAGCTGCGGTTCGGCTGCTGCCGAGAACTGCAAGGTGTGGAATATTTCTGGCT
TCTAGTCCAATGCCAAGTGTGTGACCTGTGGCTACATGATTCCCTGAAAGATAAGAACAATGTTATGTTGGGGATATTGGTCTCTGGGCC
AACCTGGTATCAGCACCAACCTGCAGGGAATTGTGGCTGAGCCCCAGGTGTGTGGGTTCATATCTGACAGAAGTGTCAAGGAAGTGGCCT
GTGGGGGAAACCACTCTGTGTTCCTGCTGGAAGATGGGGAAGTTTACACATGTGGTTTGAACACCAAGGGGCAACTGGGCCATGAGAGGG
AAGGAAACAAGCCAGTTTCAGAATGGCTTCGGTTATTGCCTTTCCTTGGTGTACTCGCACTTCTTGGCTACCTTGCAGTTCGTCCATTCC
TCCCGAAGAAGAAACAACAGAAGGATAGCTTGATTAATCTTAAAATACAAAAGGAAAATCCGAAAGTAGTGAATGAAATAAACATTGAAG
ATTTGTGTCTTACTAAAGCAGCTTATTGTAGGTGTTGGCGTTCTAAAACGTTTCCTGCCTGCGATGGTTCACATAATAAACACAATGAAT
TGACAGGAGATAATGTGGGTCCACTAATACTGAAGAAGAAAGAAGTATAATAATAATAACAATATTTTCTCATTCTTTGTGTATAGAAAA
TTTTAAAATGGTGGTCTTAATTATTACTACTGGTTGAACAATTATTTCTTCCAATTTATTTTCTTCCTGCACTACTGTTTGTATTTGATC
CTTTGTCTATTCAGTCACTTAATTAGAAATTAAATTGTCAAGCCTCTTATTCTGACTTCAAAGAATTAATGTATCTTCCAACAATAAAAT
CACTTCTGATTTTAATCTAGGAAAACCTAAATTGTGGCTATGGATCCAAAGCTGTTTGTTTCTTTGAATATCAATATTTTCAACAGGATC
TTGTATTTAAAATTCCCACCTACATTGTTAAATATGTTATTTTTTCATATCTCTTTTGGTTTTGATAATCTGAAGTGTTTTTTTCTCGTT
TTGGCCTTCCAAACTGCATTTGGTTAGGTGAATTAAGAAAAATATTGCCATCAAGAATTACTTGTGTTTTCACAGAGATAGACTCTTTGC
TTTATAGAGATTGTTGTGTATTTAATATGAATATCCCAGCTTTAGAAAAGAAGTAAACTGGATACAAAAAGTTCCATTGAGGAACAGTTA
TTTACAGTATAAAAGATTTGTTTACTTTACAAAAGGCTTGTGTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTTAAACTGACTCAG
TGACAGCTGGGGTGGAATGGCAAGAACACTTACAACCAAACTCATGGGCTGCTGCAATTTGAAGATAATTGGTAATAAACATAAGACATT
AATTCATATTAAAATAGTTCAGTGTTCAAAATTGTGTTTATGTGGATATTTTTCTCTTTTTAACACTATAAACCATTAAAATACAGTCAT
CCCTTGTATACGCTAGGGACTGGTTCCAGGGCCACACATATACCAAAATCTGCCCATACTCAAGTCCCACAGAAAGTCTTGCAGAACCCA
TATGTAGAAAAGTTGGCCCTCCAGTTGACCCTCCGTACACATGAGTTTCACATCCCATGCACAAATGCTGATCTGTGTGACCTCACCTGC
ATTTGATTGAAAAAAGTATGCGCGTAATTGTACCCACCCAGTTCAAACCCGTGTGTAAGGGTCAACTGTACAAAAAAGTTTGTGAAATAA
ACGTACTGGAGAATCTTTAAAATTTTTGTGCTTTTTAATCCTACTATTATGAATCTTTTTAGTTTCATCTTACATTACTACTCTCATAAT
AGCTATCCTTAGCCAGGTGCCATGGCACAGGCCTGTAGTCCCAACTGCTGGGAAGATTGAGGTGGGAGGATGGCTGCAGTACAAGAGCCC
AGGAGTTCAAGGCCAGGCTGGGCAACCTAGTGCTCCGCCTCTGCTGGGCTCTGTAGGGAATCCTTTCTGTTGTAAAAGAGTTACCATTTA
ACTCCCTTCACTGAGTGCGTTTCTGAGACCTTGCTAGGCACTCTGGAAACTGCTTAGTTGAGAAAAGACAAATACAAAAGCTTTTCTTTA
GTCTATTTAAGATACAGTTTATTCAGTTCACTTTGCTTTCTTTTTATAAGAATGTACAAGAGGCAGACAGAGGTAATCCTTCTAGAAATA
AAACTAATTGTTATTGGGCACTTGTATGTACCAGACACTACACTAAGCATGGTACTTGGGTTTTTAATTTATTACATGTAATGTCAGTAG
GTTCAATTATATGATCGTAACATCTTCATGACCAGCAGCATGTATTTTAGAGTTAGAAATGTAGTCTGGTTTTTGAGAAGTTTTACAAGG

>In-frame_ENST00000402738_ENST00000273986_TCGA-BR-8295-01A_HERC3_chr4_89527200_+_CISD2_chr4_103806373_length(amino acids)=176AA_start in transcript=239_stop in transcript=769
MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPVSEWLRLLPFLGVLA

--------------------------------------------------------------
>In-frame_ENST00000402738_ENST00000503643_TCGA-BR-8295-01A_HERC3_chr4_89527200_+_CISD2_chr4_103806373_length(transcript)=1096nt_BP=465nt
GGTGCGAAGCCATTCACCCAGCGCATTCCGCCGCCCGCAGGCTTGCGGGGAAACTTCCTTATTATTGTGACGCCGAAAACGGAGAAACCC
CGGGTCCGGCGAGAGGGGCTGTGACAGTCGGAGTCCCAAGCTGCGGTTCGGCTGCTGCCGAGAACTGCAAGGTGTGGAATATTTCTGGCT
TCTAGTCCAATGCCAAGTGTGTGACCTGTGGCTACATGATTCCCTGAAAGATAAGAACAATGTTATGTTGGGGATATTGGTCTCTGGGCC
AACCTGGTATCAGCACCAACCTGCAGGGAATTGTGGCTGAGCCCCAGGTGTGTGGGTTCATATCTGACAGAAGTGTCAAGGAAGTGGCCT
GTGGGGGAAACCACTCTGTGTTCCTGCTGGAAGATGGGGAAGTTTACACATGTGGTTTGAACACCAAGGGGCAACTGGGCCATGAGAGGG
AAGGAAACAAGCCAGTTTCAGAATGGCTTCGGTTATTGCCTTTCCTTGGTGTACTCGCACTTCTTGGCTACCTTGCAGTTCGTCCATTCC
TCCCGAAGAAGAAACAACAGAAGGATAGCTTGATTAATCTTAAAATACAAAAGGAAAATCCGAAAGTAGTGAATGAAATAAACATTGAAG
ATTTGTGTCTTACTAAAGCAGCTTATTGTAGGTGTTGGCGTTCTAAAACGTTTCCTGCCTGCGATGGTTCACATAATAAACACAATGAAT
TGACAGGAGATAATGTGGGTCCACTAATACTGAAGAAGAAAGAAGTATAATAATAATAACAATATTTTCTCATTCTTTGTGTATAGAAAA
TTTTAAAATGGTGGTCTTAATTATTACTACTGGTTGAACAATTATTTCTTCCAATTTATTTTCTTCCTGCACTACTGTTTGTATTTGATC
CTTTGTCTATTCAGTCACTTAATTAGAAATTAAATTGTCAAGCCTCTTATTCTGACTTCAAAGAATTAATGTATCTTCCAACAATAAAAT
CACTTCTGATTTTAATCTAGGAAAACCTAAATTGTGGCTATGGATCCAAAGCTGTTTGTTTCTTTGAATATCAATATTTTCAACAGGATC

>In-frame_ENST00000402738_ENST00000503643_TCGA-BR-8295-01A_HERC3_chr4_89527200_+_CISD2_chr4_103806373_length(amino acids)=176AA_start in transcript=239_stop in transcript=769
MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPVSEWLRLLPFLGVLA

--------------------------------------------------------------
>In-frame_ENST00000407637_ENST00000273986_TCGA-BR-8295-01A_HERC3_chr4_89527200_+_CISD2_chr4_103806373_length(transcript)=2509nt_BP=392nt
CGAAAACGGAGAAACCCCGGGTCCGGCGAGAGGGGCTGTGACAGTCGGAGTCCCAAGCTGCGGTTCGGCTGCTGCCGAGAACTGCAAGGT
GTGGAATATTTCTGGCTTCTAGTCCAATGCCAAGTGTGTGACCTGTGGCTACATGATTCCCTGAAAGATAAGAACAATGTTATGTTGGGG
ATATTGGTCTCTGGGCCAACCTGGTATCAGCACCAACCTGCAGGGAATTGTGGCTGAGCCCCAGGTGTGTGGGTTCATATCTGACAGAAG
TGTCAAGGAAGTGGCCTGTGGGGGAAACCACTCTGTGTTCCTGCTGGAAGATGGGGAAGTTTACACATGTGGTTTGAACACCAAGGGGCA
ACTGGGCCATGAGAGGGAAGGAAACAAGCCAGTTTCAGAATGGCTTCGGTTATTGCCTTTCCTTGGTGTACTCGCACTTCTTGGCTACCT
TGCAGTTCGTCCATTCCTCCCGAAGAAGAAACAACAGAAGGATAGCTTGATTAATCTTAAAATACAAAAGGAAAATCCGAAAGTAGTGAA
TGAAATAAACATTGAAGATTTGTGTCTTACTAAAGCAGCTTATTGTAGGTGTTGGCGTTCTAAAACGTTTCCTGCCTGCGATGGTTCACA
TAATAAACACAATGAATTGACAGGAGATAATGTGGGTCCACTAATACTGAAGAAGAAAGAAGTATAATAATAATAACAATATTTTCTCAT
TCTTTGTGTATAGAAAATTTTAAAATGGTGGTCTTAATTATTACTACTGGTTGAACAATTATTTCTTCCAATTTATTTTCTTCCTGCACT
ACTGTTTGTATTTGATCCTTTGTCTATTCAGTCACTTAATTAGAAATTAAATTGTCAAGCCTCTTATTCTGACTTCAAAGAATTAATGTA
TCTTCCAACAATAAAATCACTTCTGATTTTAATCTAGGAAAACCTAAATTGTGGCTATGGATCCAAAGCTGTTTGTTTCTTTGAATATCA
ATATTTTCAACAGGATCTTGTATTTAAAATTCCCACCTACATTGTTAAATATGTTATTTTTTCATATCTCTTTTGGTTTTGATAATCTGA
AGTGTTTTTTTCTCGTTTTGGCCTTCCAAACTGCATTTGGTTAGGTGAATTAAGAAAAATATTGCCATCAAGAATTACTTGTGTTTTCAC
AGAGATAGACTCTTTGCTTTATAGAGATTGTTGTGTATTTAATATGAATATCCCAGCTTTAGAAAAGAAGTAAACTGGATACAAAAAGTT
CCATTGAGGAACAGTTATTTACAGTATAAAAGATTTGTTTACTTTACAAAAGGCTTGTGTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGT
ATTTTAAACTGACTCAGTGACAGCTGGGGTGGAATGGCAAGAACACTTACAACCAAACTCATGGGCTGCTGCAATTTGAAGATAATTGGT
AATAAACATAAGACATTAATTCATATTAAAATAGTTCAGTGTTCAAAATTGTGTTTATGTGGATATTTTTCTCTTTTTAACACTATAAAC
CATTAAAATACAGTCATCCCTTGTATACGCTAGGGACTGGTTCCAGGGCCACACATATACCAAAATCTGCCCATACTCAAGTCCCACAGA
AAGTCTTGCAGAACCCATATGTAGAAAAGTTGGCCCTCCAGTTGACCCTCCGTACACATGAGTTTCACATCCCATGCACAAATGCTGATC
TGTGTGACCTCACCTGCATTTGATTGAAAAAAGTATGCGCGTAATTGTACCCACCCAGTTCAAACCCGTGTGTAAGGGTCAACTGTACAA
AAAAGTTTGTGAAATAAACGTACTGGAGAATCTTTAAAATTTTTGTGCTTTTTAATCCTACTATTATGAATCTTTTTAGTTTCATCTTAC
ATTACTACTCTCATAATAGCTATCCTTAGCCAGGTGCCATGGCACAGGCCTGTAGTCCCAACTGCTGGGAAGATTGAGGTGGGAGGATGG
CTGCAGTACAAGAGCCCAGGAGTTCAAGGCCAGGCTGGGCAACCTAGTGCTCCGCCTCTGCTGGGCTCTGTAGGGAATCCTTTCTGTTGT
AAAAGAGTTACCATTTAACTCCCTTCACTGAGTGCGTTTCTGAGACCTTGCTAGGCACTCTGGAAACTGCTTAGTTGAGAAAAGACAAAT
ACAAAAGCTTTTCTTTAGTCTATTTAAGATACAGTTTATTCAGTTCACTTTGCTTTCTTTTTATAAGAATGTACAAGAGGCAGACAGAGG
TAATCCTTCTAGAAATAAAACTAATTGTTATTGGGCACTTGTATGTACCAGACACTACACTAAGCATGGTACTTGGGTTTTTAATTTATT
ACATGTAATGTCAGTAGGTTCAATTATATGATCGTAACATCTTCATGACCAGCAGCATGTATTTTAGAGTTAGAAATGTAGTCTGGTTTT

>In-frame_ENST00000407637_ENST00000273986_TCGA-BR-8295-01A_HERC3_chr4_89527200_+_CISD2_chr4_103806373_length(amino acids)=176AA_start in transcript=166_stop in transcript=696
MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPVSEWLRLLPFLGVLA

--------------------------------------------------------------
>In-frame_ENST00000407637_ENST00000503643_TCGA-BR-8295-01A_HERC3_chr4_89527200_+_CISD2_chr4_103806373_length(transcript)=1023nt_BP=392nt
CGAAAACGGAGAAACCCCGGGTCCGGCGAGAGGGGCTGTGACAGTCGGAGTCCCAAGCTGCGGTTCGGCTGCTGCCGAGAACTGCAAGGT
GTGGAATATTTCTGGCTTCTAGTCCAATGCCAAGTGTGTGACCTGTGGCTACATGATTCCCTGAAAGATAAGAACAATGTTATGTTGGGG
ATATTGGTCTCTGGGCCAACCTGGTATCAGCACCAACCTGCAGGGAATTGTGGCTGAGCCCCAGGTGTGTGGGTTCATATCTGACAGAAG
TGTCAAGGAAGTGGCCTGTGGGGGAAACCACTCTGTGTTCCTGCTGGAAGATGGGGAAGTTTACACATGTGGTTTGAACACCAAGGGGCA
ACTGGGCCATGAGAGGGAAGGAAACAAGCCAGTTTCAGAATGGCTTCGGTTATTGCCTTTCCTTGGTGTACTCGCACTTCTTGGCTACCT
TGCAGTTCGTCCATTCCTCCCGAAGAAGAAACAACAGAAGGATAGCTTGATTAATCTTAAAATACAAAAGGAAAATCCGAAAGTAGTGAA
TGAAATAAACATTGAAGATTTGTGTCTTACTAAAGCAGCTTATTGTAGGTGTTGGCGTTCTAAAACGTTTCCTGCCTGCGATGGTTCACA
TAATAAACACAATGAATTGACAGGAGATAATGTGGGTCCACTAATACTGAAGAAGAAAGAAGTATAATAATAATAACAATATTTTCTCAT
TCTTTGTGTATAGAAAATTTTAAAATGGTGGTCTTAATTATTACTACTGGTTGAACAATTATTTCTTCCAATTTATTTTCTTCCTGCACT
ACTGTTTGTATTTGATCCTTTGTCTATTCAGTCACTTAATTAGAAATTAAATTGTCAAGCCTCTTATTCTGACTTCAAAGAATTAATGTA
TCTTCCAACAATAAAATCACTTCTGATTTTAATCTAGGAAAACCTAAATTGTGGCTATGGATCCAAAGCTGTTTGTTTCTTTGAATATCA

>In-frame_ENST00000407637_ENST00000503643_TCGA-BR-8295-01A_HERC3_chr4_89527200_+_CISD2_chr4_103806373_length(amino acids)=176AA_start in transcript=166_stop in transcript=696
MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPVSEWLRLLPFLGVLA

--------------------------------------------------------------
>In-frame_ENST00000264345_ENST00000273986_TCGA-BR-8295-01A_HERC3_chr4_89527200_+_CISD2_chr4_103806373_length(transcript)=2373nt_BP=256nt
GGCTACATGATTCCCTGAAAGATAAGAACAATGTTATGTTGGGGATATTGGTCTCTGGGCCAACCTGGTATCAGCACCAACCTGCAGGGA
ATTGTGGCTGAGCCCCAGGTGTGTGGGTTCATATCTGACAGAAGTGTCAAGGAAGTGGCCTGTGGGGGAAACCACTCTGTGTTCCTGCTG
GAAGATGGGGAAGTTTACACATGTGGTTTGAACACCAAGGGGCAACTGGGCCATGAGAGGGAAGGAAACAAGCCAGTTTCAGAATGGCTT
CGGTTATTGCCTTTCCTTGGTGTACTCGCACTTCTTGGCTACCTTGCAGTTCGTCCATTCCTCCCGAAGAAGAAACAACAGAAGGATAGC
TTGATTAATCTTAAAATACAAAAGGAAAATCCGAAAGTAGTGAATGAAATAAACATTGAAGATTTGTGTCTTACTAAAGCAGCTTATTGT
AGGTGTTGGCGTTCTAAAACGTTTCCTGCCTGCGATGGTTCACATAATAAACACAATGAATTGACAGGAGATAATGTGGGTCCACTAATA
CTGAAGAAGAAAGAAGTATAATAATAATAACAATATTTTCTCATTCTTTGTGTATAGAAAATTTTAAAATGGTGGTCTTAATTATTACTA
CTGGTTGAACAATTATTTCTTCCAATTTATTTTCTTCCTGCACTACTGTTTGTATTTGATCCTTTGTCTATTCAGTCACTTAATTAGAAA
TTAAATTGTCAAGCCTCTTATTCTGACTTCAAAGAATTAATGTATCTTCCAACAATAAAATCACTTCTGATTTTAATCTAGGAAAACCTA
AATTGTGGCTATGGATCCAAAGCTGTTTGTTTCTTTGAATATCAATATTTTCAACAGGATCTTGTATTTAAAATTCCCACCTACATTGTT
AAATATGTTATTTTTTCATATCTCTTTTGGTTTTGATAATCTGAAGTGTTTTTTTCTCGTTTTGGCCTTCCAAACTGCATTTGGTTAGGT
GAATTAAGAAAAATATTGCCATCAAGAATTACTTGTGTTTTCACAGAGATAGACTCTTTGCTTTATAGAGATTGTTGTGTATTTAATATG
AATATCCCAGCTTTAGAAAAGAAGTAAACTGGATACAAAAAGTTCCATTGAGGAACAGTTATTTACAGTATAAAAGATTTGTTTACTTTA
CAAAAGGCTTGTGTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTTAAACTGACTCAGTGACAGCTGGGGTGGAATGGCAAGAACAC
TTACAACCAAACTCATGGGCTGCTGCAATTTGAAGATAATTGGTAATAAACATAAGACATTAATTCATATTAAAATAGTTCAGTGTTCAA
AATTGTGTTTATGTGGATATTTTTCTCTTTTTAACACTATAAACCATTAAAATACAGTCATCCCTTGTATACGCTAGGGACTGGTTCCAG
GGCCACACATATACCAAAATCTGCCCATACTCAAGTCCCACAGAAAGTCTTGCAGAACCCATATGTAGAAAAGTTGGCCCTCCAGTTGAC
CCTCCGTACACATGAGTTTCACATCCCATGCACAAATGCTGATCTGTGTGACCTCACCTGCATTTGATTGAAAAAAGTATGCGCGTAATT
GTACCCACCCAGTTCAAACCCGTGTGTAAGGGTCAACTGTACAAAAAAGTTTGTGAAATAAACGTACTGGAGAATCTTTAAAATTTTTGT
GCTTTTTAATCCTACTATTATGAATCTTTTTAGTTTCATCTTACATTACTACTCTCATAATAGCTATCCTTAGCCAGGTGCCATGGCACA
GGCCTGTAGTCCCAACTGCTGGGAAGATTGAGGTGGGAGGATGGCTGCAGTACAAGAGCCCAGGAGTTCAAGGCCAGGCTGGGCAACCTA
GTGCTCCGCCTCTGCTGGGCTCTGTAGGGAATCCTTTCTGTTGTAAAAGAGTTACCATTTAACTCCCTTCACTGAGTGCGTTTCTGAGAC
CTTGCTAGGCACTCTGGAAACTGCTTAGTTGAGAAAAGACAAATACAAAAGCTTTTCTTTAGTCTATTTAAGATACAGTTTATTCAGTTC
ACTTTGCTTTCTTTTTATAAGAATGTACAAGAGGCAGACAGAGGTAATCCTTCTAGAAATAAAACTAATTGTTATTGGGCACTTGTATGT
ACCAGACACTACACTAAGCATGGTACTTGGGTTTTTAATTTATTACATGTAATGTCAGTAGGTTCAATTATATGATCGTAACATCTTCAT
GACCAGCAGCATGTATTTTAGAGTTAGAAATGTAGTCTGGTTTTTGAGAAGTTTTACAAGGTGTATGTCCAAAATTGTTCTTTCCTCACA

>In-frame_ENST00000264345_ENST00000273986_TCGA-BR-8295-01A_HERC3_chr4_89527200_+_CISD2_chr4_103806373_length(amino acids)=176AA_start in transcript=30_stop in transcript=560
MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPVSEWLRLLPFLGVLA

--------------------------------------------------------------
>In-frame_ENST00000264345_ENST00000503643_TCGA-BR-8295-01A_HERC3_chr4_89527200_+_CISD2_chr4_103806373_length(transcript)=887nt_BP=256nt
GGCTACATGATTCCCTGAAAGATAAGAACAATGTTATGTTGGGGATATTGGTCTCTGGGCCAACCTGGTATCAGCACCAACCTGCAGGGA
ATTGTGGCTGAGCCCCAGGTGTGTGGGTTCATATCTGACAGAAGTGTCAAGGAAGTGGCCTGTGGGGGAAACCACTCTGTGTTCCTGCTG
GAAGATGGGGAAGTTTACACATGTGGTTTGAACACCAAGGGGCAACTGGGCCATGAGAGGGAAGGAAACAAGCCAGTTTCAGAATGGCTT
CGGTTATTGCCTTTCCTTGGTGTACTCGCACTTCTTGGCTACCTTGCAGTTCGTCCATTCCTCCCGAAGAAGAAACAACAGAAGGATAGC
TTGATTAATCTTAAAATACAAAAGGAAAATCCGAAAGTAGTGAATGAAATAAACATTGAAGATTTGTGTCTTACTAAAGCAGCTTATTGT
AGGTGTTGGCGTTCTAAAACGTTTCCTGCCTGCGATGGTTCACATAATAAACACAATGAATTGACAGGAGATAATGTGGGTCCACTAATA
CTGAAGAAGAAAGAAGTATAATAATAATAACAATATTTTCTCATTCTTTGTGTATAGAAAATTTTAAAATGGTGGTCTTAATTATTACTA
CTGGTTGAACAATTATTTCTTCCAATTTATTTTCTTCCTGCACTACTGTTTGTATTTGATCCTTTGTCTATTCAGTCACTTAATTAGAAA
TTAAATTGTCAAGCCTCTTATTCTGACTTCAAAGAATTAATGTATCTTCCAACAATAAAATCACTTCTGATTTTAATCTAGGAAAACCTA

>In-frame_ENST00000264345_ENST00000503643_TCGA-BR-8295-01A_HERC3_chr4_89527200_+_CISD2_chr4_103806373_length(amino acids)=176AA_start in transcript=30_stop in transcript=560
MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPVSEWLRLLPFLGVLA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HERC3-CISD2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HERC3-CISD2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HERC3-CISD2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HERC3	C0023903	Liver neoplasms	1	CTD_human
Hgene	HERC3	C0345904	Malignant neoplasm of liver	1	CTD_human
Tgene	CISD2	C0043207	Wolfram Syndrome	6	CLINGEN;ORPHANET
Tgene	CISD2	C1858028	WOLFRAM SYNDROME 2	5	CTD_human;GENOMICS_ENGLAND
Tgene	CISD2	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human