FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:HERC4-CDKAL1 (FusionGDB2 ID:36042)

Fusion Gene Summary for HERC4-CDKAL1

check button Fusion gene summary
Fusion gene informationFusion gene name: HERC4-CDKAL1
Fusion gene ID: 36042
HgeneTgene
Gene symbol

HERC4

CDKAL1

Gene ID

26091

54901

Gene nameHECT and RLD domain containing E3 ubiquitin protein ligase 4CDK5 regulatory subunit associated protein 1 like 1
Synonyms--
Cytomap

10q21.3

6p22.3

Type of geneprotein-codingprotein-coding
Descriptionprobable E3 ubiquitin-protein ligase HERC4HECT domain and RCC1-like domain-containing protein 4HECT-type E3 ubiquitin transferase HERC4hect domain and RLD 4threonylcarbamoyladenosine tRNA methylthiotransferasetRNA-t(6)A37 methylthiotransferase
Modification date2020032720200322
UniProtAcc

Q5GLZ8

Q5VV42

Ensembl transtripts involved in fusion geneENST00000277817, ENST00000412272, 
ENST00000395198, ENST00000373700, 
ENST00000395187, ENST00000480158, 
ENST00000492996, 		ENST00000274695, 
ENST00000378624, ENST00000378610, 
ENST00000476517, 
Fusion gene scores* DoF score12 X 13 X 6=93623 X 22 X 8=4048
# samples 1530
** MAII scorelog2(15/936*10)=-2.64154602908752
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/4048*10)=-3.75417488419843
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HERC4 [Title/Abstract] AND CDKAL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHERC4(69792535)-CDKAL1(21000458), # samples:2
Anticipated loss of major functional domain due to fusion event.HERC4-CDKAL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HERC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CDKAL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FD-A3SJ-01AHERC4chr10

69792535

-CDKAL1chr6

21000458

+
ChimerDB4BLCATCGA-FD-A3SJHERC4chr10

69792534

-CDKAL1chr6

21000457

+
ChimerDB4BLCATCGA-FD-A3SJ-01AHERC4chr10

69792535

-CDKAL1chr6

21000458

+


Top

Fusion Gene ORF analysis for HERC4-CDKAL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000277817ENST00000274695HERC4chr10

69792535

-CDKAL1chr6

21000458

+
In-frameENST00000277817ENST00000378624HERC4chr10

69792535

-CDKAL1chr6

21000458

+
In-frameENST00000277817ENST00000378610HERC4chr10

69792535

-CDKAL1chr6

21000458

+
5CDS-intronENST00000277817ENST00000476517HERC4chr10

69792535

-CDKAL1chr6

21000458

+
Frame-shiftENST00000412272ENST00000274695HERC4chr10

69792535

-CDKAL1chr6

21000458

+
Frame-shiftENST00000412272ENST00000378624HERC4chr10

69792535

-CDKAL1chr6

21000458

+
Frame-shiftENST00000412272ENST00000378610HERC4chr10

69792535

-CDKAL1chr6

21000458

+
5CDS-intronENST00000412272ENST00000476517HERC4chr10

69792535

-CDKAL1chr6

21000458

+
Frame-shiftENST00000395198ENST00000274695HERC4chr10

69792535

-CDKAL1chr6

21000458

+
Frame-shiftENST00000395198ENST00000378624HERC4chr10

69792535

-CDKAL1chr6

21000458

+
Frame-shiftENST00000395198ENST00000378610HERC4chr10

69792535

-CDKAL1chr6

21000458

+
5CDS-intronENST00000395198ENST00000476517HERC4chr10

69792535

-CDKAL1chr6

21000458

+
Frame-shiftENST00000373700ENST00000274695HERC4chr10

69792535

-CDKAL1chr6

21000458

+
Frame-shiftENST00000373700ENST00000378624HERC4chr10

69792535

-CDKAL1chr6

21000458

+
Frame-shiftENST00000373700ENST00000378610HERC4chr10

69792535

-CDKAL1chr6

21000458

+
5CDS-intronENST00000373700ENST00000476517HERC4chr10

69792535

-CDKAL1chr6

21000458

+
3UTR-3CDSENST00000395187ENST00000274695HERC4chr10

69792535

-CDKAL1chr6

21000458

+
3UTR-3CDSENST00000395187ENST00000378624HERC4chr10

69792535

-CDKAL1chr6

21000458

+
3UTR-3CDSENST00000395187ENST00000378610HERC4chr10

69792535

-CDKAL1chr6

21000458

+
3UTR-intronENST00000395187ENST00000476517HERC4chr10

69792535

-CDKAL1chr6

21000458

+
intron-3CDSENST00000480158ENST00000274695HERC4chr10

69792535

-CDKAL1chr6

21000458

+
intron-3CDSENST00000480158ENST00000378624HERC4chr10

69792535

-CDKAL1chr6

21000458

+
intron-3CDSENST00000480158ENST00000378610HERC4chr10

69792535

-CDKAL1chr6

21000458

+
intron-intronENST00000480158ENST00000476517HERC4chr10

69792535

-CDKAL1chr6

21000458

+
intron-3CDSENST00000492996ENST00000274695HERC4chr10

69792535

-CDKAL1chr6

21000458

+
intron-3CDSENST00000492996ENST00000378624HERC4chr10

69792535

-CDKAL1chr6

21000458

+
intron-3CDSENST00000492996ENST00000378610HERC4chr10

69792535

-CDKAL1chr6

21000458

+
intron-intronENST00000492996ENST00000476517HERC4chr10

69792535

-CDKAL1chr6

21000458

+
In-frameENST00000277817ENST00000274695HERC4chr10

69792534

-CDKAL1chr6

21000457

+
In-frameENST00000277817ENST00000378624HERC4chr10

69792534

-CDKAL1chr6

21000457

+
In-frameENST00000277817ENST00000378610HERC4chr10

69792534

-CDKAL1chr6

21000457

+
5CDS-intronENST00000277817ENST00000476517HERC4chr10

69792534

-CDKAL1chr6

21000457

+
Frame-shiftENST00000412272ENST00000274695HERC4chr10

69792534

-CDKAL1chr6

21000457

+
Frame-shiftENST00000412272ENST00000378624HERC4chr10

69792534

-CDKAL1chr6

21000457

+
Frame-shiftENST00000412272ENST00000378610HERC4chr10

69792534

-CDKAL1chr6

21000457

+
5CDS-intronENST00000412272ENST00000476517HERC4chr10

69792534

-CDKAL1chr6

21000457

+
Frame-shiftENST00000395198ENST00000274695HERC4chr10

69792534

-CDKAL1chr6

21000457

+
Frame-shiftENST00000395198ENST00000378624HERC4chr10

69792534

-CDKAL1chr6

21000457

+
Frame-shiftENST00000395198ENST00000378610HERC4chr10

69792534

-CDKAL1chr6

21000457

+
5CDS-intronENST00000395198ENST00000476517HERC4chr10

69792534

-CDKAL1chr6

21000457

+
Frame-shiftENST00000373700ENST00000274695HERC4chr10

69792534

-CDKAL1chr6

21000457

+
Frame-shiftENST00000373700ENST00000378624HERC4chr10

69792534

-CDKAL1chr6

21000457

+
Frame-shiftENST00000373700ENST00000378610HERC4chr10

69792534

-CDKAL1chr6

21000457

+
5CDS-intronENST00000373700ENST00000476517HERC4chr10

69792534

-CDKAL1chr6

21000457

+
3UTR-3CDSENST00000395187ENST00000274695HERC4chr10

69792534

-CDKAL1chr6

21000457

+
3UTR-3CDSENST00000395187ENST00000378624HERC4chr10

69792534

-CDKAL1chr6

21000457

+
3UTR-3CDSENST00000395187ENST00000378610HERC4chr10

69792534

-CDKAL1chr6

21000457

+
3UTR-intronENST00000395187ENST00000476517HERC4chr10

69792534

-CDKAL1chr6

21000457

+
intron-3CDSENST00000480158ENST00000274695HERC4chr10

69792534

-CDKAL1chr6

21000457

+
intron-3CDSENST00000480158ENST00000378624HERC4chr10

69792534

-CDKAL1chr6

21000457

+
intron-3CDSENST00000480158ENST00000378610HERC4chr10

69792534

-CDKAL1chr6

21000457

+
intron-intronENST00000480158ENST00000476517HERC4chr10

69792534

-CDKAL1chr6

21000457

+
intron-3CDSENST00000492996ENST00000274695HERC4chr10

69792534

-CDKAL1chr6

21000457

+
intron-3CDSENST00000492996ENST00000378624HERC4chr10

69792534

-CDKAL1chr6

21000457

+
intron-3CDSENST00000492996ENST00000378610HERC4chr10

69792534

-CDKAL1chr6

21000457

+
intron-intronENST00000492996ENST00000476517HERC4chr10

69792534

-CDKAL1chr6

21000457

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000277817HERC4chr1069792535-ENST00000274695CDKAL1chr621000458+31389424951772425
ENST00000277817HERC4chr1069792535-ENST00000378624CDKAL1chr621000458+30759424951709404
ENST00000277817HERC4chr1069792535-ENST00000378610CDKAL1chr621000458+31389424951772425
ENST00000277817HERC4chr1069792534-ENST00000274695CDKAL1chr621000457+31389424951772425
ENST00000277817HERC4chr1069792534-ENST00000378624CDKAL1chr621000457+30759424951709404
ENST00000277817HERC4chr1069792534-ENST00000378610CDKAL1chr621000457+31389424951772425

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000277817ENST00000274695HERC4chr1069792535-CDKAL1chr621000458+0.0005564590.9994435
ENST00000277817ENST00000378624HERC4chr1069792535-CDKAL1chr621000458+0.0004921170.9995079
ENST00000277817ENST00000378610HERC4chr1069792535-CDKAL1chr621000458+0.0005564590.9994435
ENST00000277817ENST00000274695HERC4chr1069792534-CDKAL1chr621000457+0.0005564590.9994435
ENST00000277817ENST00000378624HERC4chr1069792534-CDKAL1chr621000457+0.0004921170.9995079
ENST00000277817ENST00000378610HERC4chr1069792534-CDKAL1chr621000457+0.0005564590.9994435

Top

Fusion Genomic Features for HERC4-CDKAL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HERC4chr1069792534-CDKAL1chr621000457+1.92E-050.9999808
HERC4chr1069792534-CDKAL1chr621000457+1.92E-050.9999808
HERC4chr1069792534-CDKAL1chr621000457+1.92E-050.9999808
HERC4chr1069792534-CDKAL1chr621000457+1.92E-050.9999808

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for HERC4-CDKAL1


check button Go to

FGviewer for the breakpoints of chr10:69792535-chr6:21000458

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HERC4

Q5GLZ8

CDKAL1

Q5VV42

FUNCTION: Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates. {ECO:0000250|UniProtKB:Q6PAV2}.FUNCTION: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. {ECO:0000250|UniProtKB:Q91WE6}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHERC4chr10:69792534chr6:21000457ENST00000395187-624730_1057205.66666666666666123.66666666666667DomainHECT
HgeneHERC4chr10:69792535chr6:21000458ENST00000395187-624730_1057205.66666666666666123.66666666666667DomainHECT
HgeneHERC4chr10:69792534chr6:21000457ENST00000277817-4231_51149.0948.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792534chr6:21000457ENST00000277817-42352_101149.0948.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792534chr6:21000457ENST00000373700-725102_154259.01050.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792534chr6:21000457ENST00000373700-725156_207259.01050.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792534chr6:21000457ENST00000373700-7251_51259.01050.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792534chr6:21000457ENST00000373700-725208_259259.01050.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792534chr6:21000457ENST00000373700-72552_101259.01050.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792534chr6:21000457ENST00000395187-624102_154205.66666666666666123.66666666666667RepeatNote=RCC1 3
HgeneHERC4chr10:69792534chr6:21000457ENST00000395187-624156_207205.66666666666666123.66666666666667RepeatNote=RCC1 4
HgeneHERC4chr10:69792534chr6:21000457ENST00000395187-6241_51205.66666666666666123.66666666666667RepeatNote=RCC1 1
HgeneHERC4chr10:69792534chr6:21000457ENST00000395187-624208_259205.66666666666666123.66666666666667RepeatNote=RCC1 5
HgeneHERC4chr10:69792534chr6:21000457ENST00000395187-624261_311205.66666666666666123.66666666666667RepeatNote=RCC1 6
HgeneHERC4chr10:69792534chr6:21000457ENST00000395187-624313_368205.66666666666666123.66666666666667RepeatNote=RCC1 7
HgeneHERC4chr10:69792534chr6:21000457ENST00000395187-62452_101205.66666666666666123.66666666666667RepeatNote=RCC1 2
HgeneHERC4chr10:69792534chr6:21000457ENST00000395198-726102_154259.01058.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792534chr6:21000457ENST00000395198-726156_207259.01058.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792534chr6:21000457ENST00000395198-7261_51259.01058.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792534chr6:21000457ENST00000395198-726208_259259.01058.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792534chr6:21000457ENST00000395198-72652_101259.01058.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792534chr6:21000457ENST00000412272-724102_154259.0980.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792534chr6:21000457ENST00000412272-724156_207259.0980.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792534chr6:21000457ENST00000412272-7241_51259.0980.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792534chr6:21000457ENST00000412272-724208_259259.0980.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792534chr6:21000457ENST00000412272-72452_101259.0980.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792535chr6:21000458ENST00000277817-4231_51149.0948.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792535chr6:21000458ENST00000277817-42352_101149.0948.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792535chr6:21000458ENST00000373700-725102_154259.01050.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792535chr6:21000458ENST00000373700-725156_207259.01050.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792535chr6:21000458ENST00000373700-7251_51259.01050.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792535chr6:21000458ENST00000373700-725208_259259.01050.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792535chr6:21000458ENST00000373700-72552_101259.01050.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792535chr6:21000458ENST00000395187-624102_154205.66666666666666123.66666666666667RepeatNote=RCC1 3
HgeneHERC4chr10:69792535chr6:21000458ENST00000395187-624156_207205.66666666666666123.66666666666667RepeatNote=RCC1 4
HgeneHERC4chr10:69792535chr6:21000458ENST00000395187-6241_51205.66666666666666123.66666666666667RepeatNote=RCC1 1
HgeneHERC4chr10:69792535chr6:21000458ENST00000395187-624208_259205.66666666666666123.66666666666667RepeatNote=RCC1 5
HgeneHERC4chr10:69792535chr6:21000458ENST00000395187-624261_311205.66666666666666123.66666666666667RepeatNote=RCC1 6
HgeneHERC4chr10:69792535chr6:21000458ENST00000395187-624313_368205.66666666666666123.66666666666667RepeatNote=RCC1 7
HgeneHERC4chr10:69792535chr6:21000458ENST00000395187-62452_101205.66666666666666123.66666666666667RepeatNote=RCC1 2
HgeneHERC4chr10:69792535chr6:21000458ENST00000395198-726102_154259.01058.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792535chr6:21000458ENST00000395198-726156_207259.01058.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792535chr6:21000458ENST00000395198-7261_51259.01058.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792535chr6:21000458ENST00000395198-726208_259259.01058.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792535chr6:21000458ENST00000395198-72652_101259.01058.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792535chr6:21000458ENST00000412272-724102_154259.0980.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792535chr6:21000458ENST00000412272-724156_207259.0980.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792535chr6:21000458ENST00000412272-7241_51259.0980.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792535chr6:21000458ENST00000412272-724208_259259.0980.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792535chr6:21000458ENST00000412272-72452_101259.0980.0RepeatNote=RCC1 2
TgeneCDKAL1chr10:69792534chr6:21000457ENST00000274695916431_493303.0580.0DomainTRAM
TgeneCDKAL1chr10:69792534chr6:21000457ENST00000378610714431_493303.0580.0DomainTRAM
TgeneCDKAL1chr10:69792534chr6:21000457ENST00000378624814431_493233.0489.0DomainTRAM
TgeneCDKAL1chr10:69792535chr6:21000458ENST00000274695916431_493303.0580.0DomainTRAM
TgeneCDKAL1chr10:69792535chr6:21000458ENST00000378610714431_493303.0580.0DomainTRAM
TgeneCDKAL1chr10:69792535chr6:21000458ENST00000378624814431_493233.0489.0DomainTRAM
TgeneCDKAL1chr10:69792534chr6:21000457ENST00000274695916556_578303.0580.0TransmembraneHelical
TgeneCDKAL1chr10:69792534chr6:21000457ENST00000378610714556_578303.0580.0TransmembraneHelical
TgeneCDKAL1chr10:69792534chr6:21000457ENST00000378624814556_578233.0489.0TransmembraneHelical
TgeneCDKAL1chr10:69792535chr6:21000458ENST00000274695916556_578303.0580.0TransmembraneHelical
TgeneCDKAL1chr10:69792535chr6:21000458ENST00000378610714556_578303.0580.0TransmembraneHelical
TgeneCDKAL1chr10:69792535chr6:21000458ENST00000378624814556_578233.0489.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHERC4chr10:69792534chr6:21000457ENST00000277817-423730_1057149.0948.0DomainHECT
HgeneHERC4chr10:69792534chr6:21000457ENST00000373700-725730_1057259.01050.0DomainHECT
HgeneHERC4chr10:69792534chr6:21000457ENST00000395198-726730_1057259.01058.0DomainHECT
HgeneHERC4chr10:69792534chr6:21000457ENST00000412272-724730_1057259.0980.0DomainHECT
HgeneHERC4chr10:69792534chr6:21000457ENST00000492996-14730_10570111.0DomainHECT
HgeneHERC4chr10:69792535chr6:21000458ENST00000277817-423730_1057149.0948.0DomainHECT
HgeneHERC4chr10:69792535chr6:21000458ENST00000373700-725730_1057259.01050.0DomainHECT
HgeneHERC4chr10:69792535chr6:21000458ENST00000395198-726730_1057259.01058.0DomainHECT
HgeneHERC4chr10:69792535chr6:21000458ENST00000412272-724730_1057259.0980.0DomainHECT
HgeneHERC4chr10:69792535chr6:21000458ENST00000492996-14730_10570111.0DomainHECT
HgeneHERC4chr10:69792534chr6:21000457ENST00000277817-423102_154149.0948.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792534chr6:21000457ENST00000277817-423156_207149.0948.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792534chr6:21000457ENST00000277817-423208_259149.0948.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792534chr6:21000457ENST00000277817-423261_311149.0948.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792534chr6:21000457ENST00000277817-423313_368149.0948.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792534chr6:21000457ENST00000373700-725261_311259.01050.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792534chr6:21000457ENST00000373700-725313_368259.01050.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792534chr6:21000457ENST00000395198-726261_311259.01058.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792534chr6:21000457ENST00000395198-726313_368259.01058.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792534chr6:21000457ENST00000412272-724261_311259.0980.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792534chr6:21000457ENST00000412272-724313_368259.0980.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792534chr6:21000457ENST00000492996-14102_1540111.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792534chr6:21000457ENST00000492996-14156_2070111.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792534chr6:21000457ENST00000492996-141_510111.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792534chr6:21000457ENST00000492996-14208_2590111.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792534chr6:21000457ENST00000492996-14261_3110111.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792534chr6:21000457ENST00000492996-14313_3680111.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792534chr6:21000457ENST00000492996-1452_1010111.0RepeatNote=RCC1 2
HgeneHERC4chr10:69792535chr6:21000458ENST00000277817-423102_154149.0948.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792535chr6:21000458ENST00000277817-423156_207149.0948.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792535chr6:21000458ENST00000277817-423208_259149.0948.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792535chr6:21000458ENST00000277817-423261_311149.0948.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792535chr6:21000458ENST00000277817-423313_368149.0948.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792535chr6:21000458ENST00000373700-725261_311259.01050.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792535chr6:21000458ENST00000373700-725313_368259.01050.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792535chr6:21000458ENST00000395198-726261_311259.01058.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792535chr6:21000458ENST00000395198-726313_368259.01058.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792535chr6:21000458ENST00000412272-724261_311259.0980.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792535chr6:21000458ENST00000412272-724313_368259.0980.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792535chr6:21000458ENST00000492996-14102_1540111.0RepeatNote=RCC1 3
HgeneHERC4chr10:69792535chr6:21000458ENST00000492996-14156_2070111.0RepeatNote=RCC1 4
HgeneHERC4chr10:69792535chr6:21000458ENST00000492996-141_510111.0RepeatNote=RCC1 1
HgeneHERC4chr10:69792535chr6:21000458ENST00000492996-14208_2590111.0RepeatNote=RCC1 5
HgeneHERC4chr10:69792535chr6:21000458ENST00000492996-14261_3110111.0RepeatNote=RCC1 6
HgeneHERC4chr10:69792535chr6:21000458ENST00000492996-14313_3680111.0RepeatNote=RCC1 7
HgeneHERC4chr10:69792535chr6:21000458ENST00000492996-1452_1010111.0RepeatNote=RCC1 2
TgeneCDKAL1chr10:69792534chr6:21000457ENST00000274695916200_431303.0580.0DomainRadical SAM core
TgeneCDKAL1chr10:69792534chr6:21000457ENST0000027469591664_172303.0580.0DomainMTTase N-terminal
TgeneCDKAL1chr10:69792534chr6:21000457ENST00000378610714200_431303.0580.0DomainRadical SAM core
TgeneCDKAL1chr10:69792534chr6:21000457ENST0000037861071464_172303.0580.0DomainMTTase N-terminal
TgeneCDKAL1chr10:69792534chr6:21000457ENST00000378624814200_431233.0489.0DomainRadical SAM core
TgeneCDKAL1chr10:69792534chr6:21000457ENST0000037862481464_172233.0489.0DomainMTTase N-terminal
TgeneCDKAL1chr10:69792535chr6:21000458ENST00000274695916200_431303.0580.0DomainRadical SAM core
TgeneCDKAL1chr10:69792535chr6:21000458ENST0000027469591664_172303.0580.0DomainMTTase N-terminal
TgeneCDKAL1chr10:69792535chr6:21000458ENST00000378610714200_431303.0580.0DomainRadical SAM core
TgeneCDKAL1chr10:69792535chr6:21000458ENST0000037861071464_172303.0580.0DomainMTTase N-terminal
TgeneCDKAL1chr10:69792535chr6:21000458ENST00000378624814200_431233.0489.0DomainRadical SAM core
TgeneCDKAL1chr10:69792535chr6:21000458ENST0000037862481464_172233.0489.0DomainMTTase N-terminal


Top

Fusion Gene Sequence for HERC4-CDKAL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000277817_ENST00000274695_TCGA-FD-A3SJ-01A_HERC4_chr10_69792535_-_CDKAL1_chr6_21000458_length(transcript)=3138nt_BP=942nt
GTGGTTAGTAGCGATAAATGCTCTGAAGGAAAAAACATACAGTACTGTGAGAATGTAGTATTTTGAAATGTTTCATTTGCAAAATTGTAC
TTGATACTCAGAATAGTGTTTTTTTTTCCTAAAATACTTAATATGCTGAACAGGTCAATGTATCATCTGCCTAGTATGCATAAACAATAA
CAGTAAATGTTTAGTAATTTGAGCACAGTTGGGTATGTTCATGTATTTTTTATTCCTTACTCTGTTTGCATTGCCAGTGTTTGATTTTGC
TATTTCAAAGAAATGGCATTTTGTTGAGTTTGAAAATTTGAAGGTGCATTGGATCCTGCTAATTTGTTGGATTCTGCTAAATTGTAGCAG
TACAGCTCTCAGGTTTTGTAGTTAAGAGCATAACTTCACTAAATAAAAATATTTTTAATACAATAATATGGAATCAGAGTAACTCTCCTT
TTTCCTGCTCAAACTTTGATTTGCTGAAGCTGCTTCCCGAAAATCATGTGTGTCGACTCTCTGGTCAGAATTTGCTCCGGACTCTCTTAT
GGCAGAATCAGAAATATTAAAAGTTTGTCAGATATCCAGATTGTACAGGTTGCTTGTGGTTACTATCATTCACTTGCACTTTCTAAAGCA
AGTGAAGTCTTCTGTTGGGGACAGAATAAATATGGCCAATTGGGTTTAGGTACTGACTGTAAAAAGCAAACTTCACCGCAGCTGCTTAAG
TCTTTGCTTGGAATCCCTTTCATGCAAGTTGCAGCAGGAGGAGCCCATAGTTTTGTACTCACCCTTTCTGGAGCTATCTTTGGATGGGGA
CGCAACAAGTTTGGTCAGCTAGGTCTTAATGATGAAAATGATAGGTATGTTCCTAATTTACTAAAGTCACTAAGATCTCAGAAAATAGTT
TATATTTGTTGTGGAGAAGATCATACTGCTGCTCTAACCAAGGAAATGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCAC
ATACCAGTCCAGTCTGCCTCCGACAGCGTACTCATGGAAATGAAAAGAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTG
AAAGAGAAAGTTCCTGGAATAACTATTGCTACAGATATTATCTGTGGTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAA
CTTGTTGAAGAGTACAAATTCCCAAGCCTGTTTATTAACCAATTTTACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCA
GCACAAGTGAAAAAGCAAAGGACAAAAGATCTTTCTCGGGTGTTTCATTCTTACAGTCCATATGATCACAAGATTGGTGAAAGACAACAA
GTGTTAGTAACAGAAGAATCTTTTGATTCCAAGTTTTATGTTGCACACAATCAATTCTATGAGCAGGTTTTAGTGCCAAAGAACCCTGCG
TTCATGGGGAAGATGGTTGAAGTGGACATCTATGAATCAGGCAAACATTTTATGAAAGGGCAGCCAGTATCTGATGCCAAAGTGTACACG
CCCTCCATCAGCAAACCGCTAGCAAAGGGAGAAGTCTCGGGTTTGACAAAGGACTTCAGAAATGGGCTTGGGAACCAGCTGAGTTCAGGA
TCCCACACCTCTGCTGCATCTCAGTGTGACTCAGCGAGTTCCAGAATGGTGCTGCCCATGCCAAGGCTACATCAAGACTGTGCGCTGAGG
ATGTCCGTGGGCTTGGCTCTGCTGGGTCTTCTTTTTGCTTTTTTTGTCAAGGTCTATAATTAGAATACAACTAATGGAAACATCTATAAA
GAAGAATACATTTCTAATTAAAATCTTCAATGAACAGGAAAGCGACATCTCCATTCTCCAAGGGCAATAATTTGTACTGGTCATGCTGCC
TCCTTCTCAGCCACTCTTCTTAATGAGGCTCCCCCTGTCTCACATTGAGTTGGGCCCATTGGTTATTTGACCTAAAACCTAATCACCGCT
ACCATAGCACATCCTTCAAATTAAACTGCTTTTGGTTTACTTTTAGCAAGAAATGCAAGCGGTTGCATTTTTTTCTGTTTGTTTCAATCT
CTAATCTTTAAGTCAGAACCTAATTGTACAGTGGCTCTGGCCATCTTTTCCTCATGTGGAAGAATTTTCTATCTTTAATAAACTTTTTCT
TTGTTTTTTTTTTCCAGATGGAGTTTCGCTCTTGTCCCCCAGGCTGGAGTGGTGCAGTGGCACGATCTCAGGTCACTGCAACCTCTGCCT
CCTGGGTTCAAACGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCATGCGCCACCAAGCCCAGACAATTTTTTTGTGTTT
TCAGTAGAGACGGAGTTTCACCATGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAAGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCT
AGGATTACAGGCGTGAGCCACTGCGCCCGGCCTCTTTAATAAATATTTTTAAGTGCATCTTCCCCTTCAGGCTTTGTTTGGAGTCCCAGT
GCTACAAACATTGTATTTTTCACAGCAGATGTGTTCCTGAAAAGTGTATAGAAACCTGTTCTGGGAACCTGAATGCTTTTGGAATGCACG
GGGAGAGTCTGCCAGCTAAAGGACTCCTGGCAACATTCTGTGAAATATGAAACTGGAAAACTGGATTTGTCGAAAACTAATTGTGCCCAT
TTTCTCACATTTTTGATCCATTGGGGTTTTTTTTTTGTTTTTGTTTTTTTTTTTTTTTGAGTCAAGGTCTCACTCTGTCACCCTGGCTGG
AGTGCAATGGCACTATCTTGGCTCACTGCAGCCTTGACCTCCTGGACTCAAGCAGTCCTCCTACCTCAGCCTCCCTAATAGCCAGGGGCT
ACAGGCATATACCACCATGCCCAACTAATTTTTTAATTTTTTGTAGAGATGAGTGTCACTATGTTGCCCAGGCTTGCCTGGAACTCCTAG
CCTCAAGCAGTCTTCTTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTCCACCCAGCCCAGATTAAATGTTTTTATTT

>In-frame_ENST00000277817_ENST00000274695_TCGA-FD-A3SJ-01A_HERC4_chr10_69792535_-_CDKAL1_chr6_21000458_length(amino acids)=425AA_start in transcript=495_stop in transcript=1772
MCVDSLVRICSGLSYGRIRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGA
HSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEMAKILNHPRVYAFLHIPVQSASDSVLMEMK
REYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVF
HSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGL

--------------------------------------------------------------
>In-frame_ENST00000277817_ENST00000378624_TCGA-FD-A3SJ-01A_HERC4_chr10_69792535_-_CDKAL1_chr6_21000458_length(transcript)=3075nt_BP=942nt
GTGGTTAGTAGCGATAAATGCTCTGAAGGAAAAAACATACAGTACTGTGAGAATGTAGTATTTTGAAATGTTTCATTTGCAAAATTGTAC
TTGATACTCAGAATAGTGTTTTTTTTTCCTAAAATACTTAATATGCTGAACAGGTCAATGTATCATCTGCCTAGTATGCATAAACAATAA
CAGTAAATGTTTAGTAATTTGAGCACAGTTGGGTATGTTCATGTATTTTTTATTCCTTACTCTGTTTGCATTGCCAGTGTTTGATTTTGC
TATTTCAAAGAAATGGCATTTTGTTGAGTTTGAAAATTTGAAGGTGCATTGGATCCTGCTAATTTGTTGGATTCTGCTAAATTGTAGCAG
TACAGCTCTCAGGTTTTGTAGTTAAGAGCATAACTTCACTAAATAAAAATATTTTTAATACAATAATATGGAATCAGAGTAACTCTCCTT
TTTCCTGCTCAAACTTTGATTTGCTGAAGCTGCTTCCCGAAAATCATGTGTGTCGACTCTCTGGTCAGAATTTGCTCCGGACTCTCTTAT
GGCAGAATCAGAAATATTAAAAGTTTGTCAGATATCCAGATTGTACAGGTTGCTTGTGGTTACTATCATTCACTTGCACTTTCTAAAGCA
AGTGAAGTCTTCTGTTGGGGACAGAATAAATATGGCCAATTGGGTTTAGGTACTGACTGTAAAAAGCAAACTTCACCGCAGCTGCTTAAG
TCTTTGCTTGGAATCCCTTTCATGCAAGTTGCAGCAGGAGGAGCCCATAGTTTTGTACTCACCCTTTCTGGAGCTATCTTTGGATGGGGA
CGCAACAAGTTTGGTCAGCTAGGTCTTAATGATGAAAATGATAGGTATGTTCCTAATTTACTAAAGTCACTAAGATCTCAGAAAATAGTT
TATATTTGTTGTGGAGAAGATCATACTGCTGCTCTAACCAAGGAAATGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCAC
ATACCAGTCCAGTCTGCCTCCGACAGCGTACTCATGGAAATGAAAAGAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTG
AAAGAGAAAGTTCCTGGAATAACTATTGCTACAGATATTATCTGTGGTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAA
CTTGTTGAAGAGTACAAATTCCCAAGCCTGTTTATTAACCAATTTTACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCA
GCACAAGTGATTGGTGAAAGACAACAAGTGTTAGTAACAGAAGAATCTTTTGATTCCAAGTTTTATGTTGCACACAATCAATTCTATGAG
CAGGTTTTAGTGCCAAAGAACCCTGCGTTCATGGGGAAGATGGTTGAAGTGGACATCTATGAATCAGGCAAACATTTTATGAAAGGGCAG
CCAGTATCTGATGCCAAAGTGTACACGCCCTCCATCAGCAAACCGCTAGCAAAGGGAGAAGTCTCGGGTTTGACAAAGGACTTCAGAAAT
GGGCTTGGGAACCAGCTGAGTTCAGGATCCCACACCTCTGCTGCATCTCAGTGTGACTCAGCGAGTTCCAGAATGGTGCTGCCCATGCCA
AGGCTACATCAAGACTGTGCGCTGAGGATGTCCGTGGGCTTGGCTCTGCTGGGTCTTCTTTTTGCTTTTTTTGTCAAGGTCTATAATTAG
AATACAACTAATGGAAACATCTATAAAGAAGAATACATTTCTAATTAAAATCTTCAATGAACAGGAAAGCGACATCTCCATTCTCCAAGG
GCAATAATTTGTACTGGTCATGCTGCCTCCTTCTCAGCCACTCTTCTTAATGAGGCTCCCCCTGTCTCACATTGAGTTGGGCCCATTGGT
TATTTGACCTAAAACCTAATCACCGCTACCATAGCACATCCTTCAAATTAAACTGCTTTTGGTTTACTTTTAGCAAGAAATGCAAGCGGT
TGCATTTTTTTCTGTTTGTTTCAATCTCTAATCTTTAAGTCAGAACCTAATTGTACAGTGGCTCTGGCCATCTTTTCCTCATGTGGAAGA
ATTTTCTATCTTTAATAAACTTTTTCTTTGTTTTTTTTTTCCAGATGGAGTTTCGCTCTTGTCCCCCAGGCTGGAGTGGTGCAGTGGCAC
GATCTCAGGTCACTGCAACCTCTGCCTCCTGGGTTCAAACGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCATGCGCCA
CCAAGCCCAGACAATTTTTTTGTGTTTTCAGTAGAGACGGAGTTTCACCATGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAAGTGAT
CCGCCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACTGCGCCCGGCCTCTTTAATAAATATTTTTAAGTGCATCTTCC
CCTTCAGGCTTTGTTTGGAGTCCCAGTGCTACAAACATTGTATTTTTCACAGCAGATGTGTTCCTGAAAAGTGTATAGAAACCTGTTCTG
GGAACCTGAATGCTTTTGGAATGCACGGGGAGAGTCTGCCAGCTAAAGGACTCCTGGCAACATTCTGTGAAATATGAAACTGGAAAACTG
GATTTGTCGAAAACTAATTGTGCCCATTTTCTCACATTTTTGATCCATTGGGGTTTTTTTTTTGTTTTTGTTTTTTTTTTTTTTTGAGTC
AAGGTCTCACTCTGTCACCCTGGCTGGAGTGCAATGGCACTATCTTGGCTCACTGCAGCCTTGACCTCCTGGACTCAAGCAGTCCTCCTA
CCTCAGCCTCCCTAATAGCCAGGGGCTACAGGCATATACCACCATGCCCAACTAATTTTTTAATTTTTTGTAGAGATGAGTGTCACTATG
TTGCCCAGGCTTGCCTGGAACTCCTAGCCTCAAGCAGTCTTCTTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTCCA
CCCAGCCCAGATTAAATGTTTTTATTTCTACCTGCCATCATTGGTCTTTACTAAGTGAAGTGACTTCTTTCTTTAACAATAAATAGAATT

>In-frame_ENST00000277817_ENST00000378624_TCGA-FD-A3SJ-01A_HERC4_chr10_69792535_-_CDKAL1_chr6_21000458_length(amino acids)=404AA_start in transcript=495_stop in transcript=1709
MCVDSLVRICSGLSYGRIRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGA
HSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEMAKILNHPRVYAFLHIPVQSASDSVLMEMK
REYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVIGERQQVLVTEE
SFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSHTSAA

--------------------------------------------------------------
>In-frame_ENST00000277817_ENST00000378610_TCGA-FD-A3SJ-01A_HERC4_chr10_69792535_-_CDKAL1_chr6_21000458_length(transcript)=3138nt_BP=942nt
GTGGTTAGTAGCGATAAATGCTCTGAAGGAAAAAACATACAGTACTGTGAGAATGTAGTATTTTGAAATGTTTCATTTGCAAAATTGTAC
TTGATACTCAGAATAGTGTTTTTTTTTCCTAAAATACTTAATATGCTGAACAGGTCAATGTATCATCTGCCTAGTATGCATAAACAATAA
CAGTAAATGTTTAGTAATTTGAGCACAGTTGGGTATGTTCATGTATTTTTTATTCCTTACTCTGTTTGCATTGCCAGTGTTTGATTTTGC
TATTTCAAAGAAATGGCATTTTGTTGAGTTTGAAAATTTGAAGGTGCATTGGATCCTGCTAATTTGTTGGATTCTGCTAAATTGTAGCAG
TACAGCTCTCAGGTTTTGTAGTTAAGAGCATAACTTCACTAAATAAAAATATTTTTAATACAATAATATGGAATCAGAGTAACTCTCCTT
TTTCCTGCTCAAACTTTGATTTGCTGAAGCTGCTTCCCGAAAATCATGTGTGTCGACTCTCTGGTCAGAATTTGCTCCGGACTCTCTTAT
GGCAGAATCAGAAATATTAAAAGTTTGTCAGATATCCAGATTGTACAGGTTGCTTGTGGTTACTATCATTCACTTGCACTTTCTAAAGCA
AGTGAAGTCTTCTGTTGGGGACAGAATAAATATGGCCAATTGGGTTTAGGTACTGACTGTAAAAAGCAAACTTCACCGCAGCTGCTTAAG
TCTTTGCTTGGAATCCCTTTCATGCAAGTTGCAGCAGGAGGAGCCCATAGTTTTGTACTCACCCTTTCTGGAGCTATCTTTGGATGGGGA
CGCAACAAGTTTGGTCAGCTAGGTCTTAATGATGAAAATGATAGGTATGTTCCTAATTTACTAAAGTCACTAAGATCTCAGAAAATAGTT
TATATTTGTTGTGGAGAAGATCATACTGCTGCTCTAACCAAGGAAATGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCAC
ATACCAGTCCAGTCTGCCTCCGACAGCGTACTCATGGAAATGAAAAGAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTG
AAAGAGAAAGTTCCTGGAATAACTATTGCTACAGATATTATCTGTGGTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAA
CTTGTTGAAGAGTACAAATTCCCAAGCCTGTTTATTAACCAATTTTACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCA
GCACAAGTGAAAAAGCAAAGGACAAAAGATCTTTCTCGGGTGTTTCATTCTTACAGTCCATATGATCACAAGATTGGTGAAAGACAACAA
GTGTTAGTAACAGAAGAATCTTTTGATTCCAAGTTTTATGTTGCACACAATCAATTCTATGAGCAGGTTTTAGTGCCAAAGAACCCTGCG
TTCATGGGGAAGATGGTTGAAGTGGACATCTATGAATCAGGCAAACATTTTATGAAAGGGCAGCCAGTATCTGATGCCAAAGTGTACACG
CCCTCCATCAGCAAACCGCTAGCAAAGGGAGAAGTCTCGGGTTTGACAAAGGACTTCAGAAATGGGCTTGGGAACCAGCTGAGTTCAGGA
TCCCACACCTCTGCTGCATCTCAGTGTGACTCAGCGAGTTCCAGAATGGTGCTGCCCATGCCAAGGCTACATCAAGACTGTGCGCTGAGG
ATGTCCGTGGGCTTGGCTCTGCTGGGTCTTCTTTTTGCTTTTTTTGTCAAGGTCTATAATTAGAATACAACTAATGGAAACATCTATAAA
GAAGAATACATTTCTAATTAAAATCTTCAATGAACAGGAAAGCGACATCTCCATTCTCCAAGGGCAATAATTTGTACTGGTCATGCTGCC
TCCTTCTCAGCCACTCTTCTTAATGAGGCTCCCCCTGTCTCACATTGAGTTGGGCCCATTGGTTATTTGACCTAAAACCTAATCACCGCT
ACCATAGCACATCCTTCAAATTAAACTGCTTTTGGTTTACTTTTAGCAAGAAATGCAAGCGGTTGCATTTTTTTCTGTTTGTTTCAATCT
CTAATCTTTAAGTCAGAACCTAATTGTACAGTGGCTCTGGCCATCTTTTCCTCATGTGGAAGAATTTTCTATCTTTAATAAACTTTTTCT
TTGTTTTTTTTTTCCAGATGGAGTTTCGCTCTTGTCCCCCAGGCTGGAGTGGTGCAGTGGCACGATCTCAGGTCACTGCAACCTCTGCCT
CCTGGGTTCAAACGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCATGCGCCACCAAGCCCAGACAATTTTTTTGTGTTT
TCAGTAGAGACGGAGTTTCACCATGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAAGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCT
AGGATTACAGGCGTGAGCCACTGCGCCCGGCCTCTTTAATAAATATTTTTAAGTGCATCTTCCCCTTCAGGCTTTGTTTGGAGTCCCAGT
GCTACAAACATTGTATTTTTCACAGCAGATGTGTTCCTGAAAAGTGTATAGAAACCTGTTCTGGGAACCTGAATGCTTTTGGAATGCACG
GGGAGAGTCTGCCAGCTAAAGGACTCCTGGCAACATTCTGTGAAATATGAAACTGGAAAACTGGATTTGTCGAAAACTAATTGTGCCCAT
TTTCTCACATTTTTGATCCATTGGGGTTTTTTTTTTGTTTTTGTTTTTTTTTTTTTTTGAGTCAAGGTCTCACTCTGTCACCCTGGCTGG
AGTGCAATGGCACTATCTTGGCTCACTGCAGCCTTGACCTCCTGGACTCAAGCAGTCCTCCTACCTCAGCCTCCCTAATAGCCAGGGGCT
ACAGGCATATACCACCATGCCCAACTAATTTTTTAATTTTTTGTAGAGATGAGTGTCACTATGTTGCCCAGGCTTGCCTGGAACTCCTAG
CCTCAAGCAGTCTTCTTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTCCACCCAGCCCAGATTAAATGTTTTTATTT

>In-frame_ENST00000277817_ENST00000378610_TCGA-FD-A3SJ-01A_HERC4_chr10_69792535_-_CDKAL1_chr6_21000458_length(amino acids)=425AA_start in transcript=495_stop in transcript=1772
MCVDSLVRICSGLSYGRIRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGA
HSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEMAKILNHPRVYAFLHIPVQSASDSVLMEMK
REYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVF
HSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGL

--------------------------------------------------------------
>In-frame_ENST00000277817_ENST00000274695_TCGA-FD-A3SJ_HERC4_chr10_69792534_-_CDKAL1_chr6_21000457_length(transcript)=3138nt_BP=942nt
GTGGTTAGTAGCGATAAATGCTCTGAAGGAAAAAACATACAGTACTGTGAGAATGTAGTATTTTGAAATGTTTCATTTGCAAAATTGTAC
TTGATACTCAGAATAGTGTTTTTTTTTCCTAAAATACTTAATATGCTGAACAGGTCAATGTATCATCTGCCTAGTATGCATAAACAATAA
CAGTAAATGTTTAGTAATTTGAGCACAGTTGGGTATGTTCATGTATTTTTTATTCCTTACTCTGTTTGCATTGCCAGTGTTTGATTTTGC
TATTTCAAAGAAATGGCATTTTGTTGAGTTTGAAAATTTGAAGGTGCATTGGATCCTGCTAATTTGTTGGATTCTGCTAAATTGTAGCAG
TACAGCTCTCAGGTTTTGTAGTTAAGAGCATAACTTCACTAAATAAAAATATTTTTAATACAATAATATGGAATCAGAGTAACTCTCCTT
TTTCCTGCTCAAACTTTGATTTGCTGAAGCTGCTTCCCGAAAATCATGTGTGTCGACTCTCTGGTCAGAATTTGCTCCGGACTCTCTTAT
GGCAGAATCAGAAATATTAAAAGTTTGTCAGATATCCAGATTGTACAGGTTGCTTGTGGTTACTATCATTCACTTGCACTTTCTAAAGCA
AGTGAAGTCTTCTGTTGGGGACAGAATAAATATGGCCAATTGGGTTTAGGTACTGACTGTAAAAAGCAAACTTCACCGCAGCTGCTTAAG
TCTTTGCTTGGAATCCCTTTCATGCAAGTTGCAGCAGGAGGAGCCCATAGTTTTGTACTCACCCTTTCTGGAGCTATCTTTGGATGGGGA
CGCAACAAGTTTGGTCAGCTAGGTCTTAATGATGAAAATGATAGGTATGTTCCTAATTTACTAAAGTCACTAAGATCTCAGAAAATAGTT
TATATTTGTTGTGGAGAAGATCATACTGCTGCTCTAACCAAGGAAATGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCAC
ATACCAGTCCAGTCTGCCTCCGACAGCGTACTCATGGAAATGAAAAGAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTG
AAAGAGAAAGTTCCTGGAATAACTATTGCTACAGATATTATCTGTGGTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAA
CTTGTTGAAGAGTACAAATTCCCAAGCCTGTTTATTAACCAATTTTACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCA
GCACAAGTGAAAAAGCAAAGGACAAAAGATCTTTCTCGGGTGTTTCATTCTTACAGTCCATATGATCACAAGATTGGTGAAAGACAACAA
GTGTTAGTAACAGAAGAATCTTTTGATTCCAAGTTTTATGTTGCACACAATCAATTCTATGAGCAGGTTTTAGTGCCAAAGAACCCTGCG
TTCATGGGGAAGATGGTTGAAGTGGACATCTATGAATCAGGCAAACATTTTATGAAAGGGCAGCCAGTATCTGATGCCAAAGTGTACACG
CCCTCCATCAGCAAACCGCTAGCAAAGGGAGAAGTCTCGGGTTTGACAAAGGACTTCAGAAATGGGCTTGGGAACCAGCTGAGTTCAGGA
TCCCACACCTCTGCTGCATCTCAGTGTGACTCAGCGAGTTCCAGAATGGTGCTGCCCATGCCAAGGCTACATCAAGACTGTGCGCTGAGG
ATGTCCGTGGGCTTGGCTCTGCTGGGTCTTCTTTTTGCTTTTTTTGTCAAGGTCTATAATTAGAATACAACTAATGGAAACATCTATAAA
GAAGAATACATTTCTAATTAAAATCTTCAATGAACAGGAAAGCGACATCTCCATTCTCCAAGGGCAATAATTTGTACTGGTCATGCTGCC
TCCTTCTCAGCCACTCTTCTTAATGAGGCTCCCCCTGTCTCACATTGAGTTGGGCCCATTGGTTATTTGACCTAAAACCTAATCACCGCT
ACCATAGCACATCCTTCAAATTAAACTGCTTTTGGTTTACTTTTAGCAAGAAATGCAAGCGGTTGCATTTTTTTCTGTTTGTTTCAATCT
CTAATCTTTAAGTCAGAACCTAATTGTACAGTGGCTCTGGCCATCTTTTCCTCATGTGGAAGAATTTTCTATCTTTAATAAACTTTTTCT
TTGTTTTTTTTTTCCAGATGGAGTTTCGCTCTTGTCCCCCAGGCTGGAGTGGTGCAGTGGCACGATCTCAGGTCACTGCAACCTCTGCCT
CCTGGGTTCAAACGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCATGCGCCACCAAGCCCAGACAATTTTTTTGTGTTT
TCAGTAGAGACGGAGTTTCACCATGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAAGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCT
AGGATTACAGGCGTGAGCCACTGCGCCCGGCCTCTTTAATAAATATTTTTAAGTGCATCTTCCCCTTCAGGCTTTGTTTGGAGTCCCAGT
GCTACAAACATTGTATTTTTCACAGCAGATGTGTTCCTGAAAAGTGTATAGAAACCTGTTCTGGGAACCTGAATGCTTTTGGAATGCACG
GGGAGAGTCTGCCAGCTAAAGGACTCCTGGCAACATTCTGTGAAATATGAAACTGGAAAACTGGATTTGTCGAAAACTAATTGTGCCCAT
TTTCTCACATTTTTGATCCATTGGGGTTTTTTTTTTGTTTTTGTTTTTTTTTTTTTTTGAGTCAAGGTCTCACTCTGTCACCCTGGCTGG
AGTGCAATGGCACTATCTTGGCTCACTGCAGCCTTGACCTCCTGGACTCAAGCAGTCCTCCTACCTCAGCCTCCCTAATAGCCAGGGGCT
ACAGGCATATACCACCATGCCCAACTAATTTTTTAATTTTTTGTAGAGATGAGTGTCACTATGTTGCCCAGGCTTGCCTGGAACTCCTAG
CCTCAAGCAGTCTTCTTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTCCACCCAGCCCAGATTAAATGTTTTTATTT

>In-frame_ENST00000277817_ENST00000274695_TCGA-FD-A3SJ_HERC4_chr10_69792534_-_CDKAL1_chr6_21000457_length(amino acids)=425AA_start in transcript=495_stop in transcript=1772
MCVDSLVRICSGLSYGRIRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGA
HSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEMAKILNHPRVYAFLHIPVQSASDSVLMEMK
REYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVF
HSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGL

--------------------------------------------------------------
>In-frame_ENST00000277817_ENST00000378624_TCGA-FD-A3SJ_HERC4_chr10_69792534_-_CDKAL1_chr6_21000457_length(transcript)=3075nt_BP=942nt
GTGGTTAGTAGCGATAAATGCTCTGAAGGAAAAAACATACAGTACTGTGAGAATGTAGTATTTTGAAATGTTTCATTTGCAAAATTGTAC
TTGATACTCAGAATAGTGTTTTTTTTTCCTAAAATACTTAATATGCTGAACAGGTCAATGTATCATCTGCCTAGTATGCATAAACAATAA
CAGTAAATGTTTAGTAATTTGAGCACAGTTGGGTATGTTCATGTATTTTTTATTCCTTACTCTGTTTGCATTGCCAGTGTTTGATTTTGC
TATTTCAAAGAAATGGCATTTTGTTGAGTTTGAAAATTTGAAGGTGCATTGGATCCTGCTAATTTGTTGGATTCTGCTAAATTGTAGCAG
TACAGCTCTCAGGTTTTGTAGTTAAGAGCATAACTTCACTAAATAAAAATATTTTTAATACAATAATATGGAATCAGAGTAACTCTCCTT
TTTCCTGCTCAAACTTTGATTTGCTGAAGCTGCTTCCCGAAAATCATGTGTGTCGACTCTCTGGTCAGAATTTGCTCCGGACTCTCTTAT
GGCAGAATCAGAAATATTAAAAGTTTGTCAGATATCCAGATTGTACAGGTTGCTTGTGGTTACTATCATTCACTTGCACTTTCTAAAGCA
AGTGAAGTCTTCTGTTGGGGACAGAATAAATATGGCCAATTGGGTTTAGGTACTGACTGTAAAAAGCAAACTTCACCGCAGCTGCTTAAG
TCTTTGCTTGGAATCCCTTTCATGCAAGTTGCAGCAGGAGGAGCCCATAGTTTTGTACTCACCCTTTCTGGAGCTATCTTTGGATGGGGA
CGCAACAAGTTTGGTCAGCTAGGTCTTAATGATGAAAATGATAGGTATGTTCCTAATTTACTAAAGTCACTAAGATCTCAGAAAATAGTT
TATATTTGTTGTGGAGAAGATCATACTGCTGCTCTAACCAAGGAAATGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCAC
ATACCAGTCCAGTCTGCCTCCGACAGCGTACTCATGGAAATGAAAAGAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTG
AAAGAGAAAGTTCCTGGAATAACTATTGCTACAGATATTATCTGTGGTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAA
CTTGTTGAAGAGTACAAATTCCCAAGCCTGTTTATTAACCAATTTTACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCA
GCACAAGTGATTGGTGAAAGACAACAAGTGTTAGTAACAGAAGAATCTTTTGATTCCAAGTTTTATGTTGCACACAATCAATTCTATGAG
CAGGTTTTAGTGCCAAAGAACCCTGCGTTCATGGGGAAGATGGTTGAAGTGGACATCTATGAATCAGGCAAACATTTTATGAAAGGGCAG
CCAGTATCTGATGCCAAAGTGTACACGCCCTCCATCAGCAAACCGCTAGCAAAGGGAGAAGTCTCGGGTTTGACAAAGGACTTCAGAAAT
GGGCTTGGGAACCAGCTGAGTTCAGGATCCCACACCTCTGCTGCATCTCAGTGTGACTCAGCGAGTTCCAGAATGGTGCTGCCCATGCCA
AGGCTACATCAAGACTGTGCGCTGAGGATGTCCGTGGGCTTGGCTCTGCTGGGTCTTCTTTTTGCTTTTTTTGTCAAGGTCTATAATTAG
AATACAACTAATGGAAACATCTATAAAGAAGAATACATTTCTAATTAAAATCTTCAATGAACAGGAAAGCGACATCTCCATTCTCCAAGG
GCAATAATTTGTACTGGTCATGCTGCCTCCTTCTCAGCCACTCTTCTTAATGAGGCTCCCCCTGTCTCACATTGAGTTGGGCCCATTGGT
TATTTGACCTAAAACCTAATCACCGCTACCATAGCACATCCTTCAAATTAAACTGCTTTTGGTTTACTTTTAGCAAGAAATGCAAGCGGT
TGCATTTTTTTCTGTTTGTTTCAATCTCTAATCTTTAAGTCAGAACCTAATTGTACAGTGGCTCTGGCCATCTTTTCCTCATGTGGAAGA
ATTTTCTATCTTTAATAAACTTTTTCTTTGTTTTTTTTTTCCAGATGGAGTTTCGCTCTTGTCCCCCAGGCTGGAGTGGTGCAGTGGCAC
GATCTCAGGTCACTGCAACCTCTGCCTCCTGGGTTCAAACGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCATGCGCCA
CCAAGCCCAGACAATTTTTTTGTGTTTTCAGTAGAGACGGAGTTTCACCATGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAAGTGAT
CCGCCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACTGCGCCCGGCCTCTTTAATAAATATTTTTAAGTGCATCTTCC
CCTTCAGGCTTTGTTTGGAGTCCCAGTGCTACAAACATTGTATTTTTCACAGCAGATGTGTTCCTGAAAAGTGTATAGAAACCTGTTCTG
GGAACCTGAATGCTTTTGGAATGCACGGGGAGAGTCTGCCAGCTAAAGGACTCCTGGCAACATTCTGTGAAATATGAAACTGGAAAACTG
GATTTGTCGAAAACTAATTGTGCCCATTTTCTCACATTTTTGATCCATTGGGGTTTTTTTTTTGTTTTTGTTTTTTTTTTTTTTTGAGTC
AAGGTCTCACTCTGTCACCCTGGCTGGAGTGCAATGGCACTATCTTGGCTCACTGCAGCCTTGACCTCCTGGACTCAAGCAGTCCTCCTA
CCTCAGCCTCCCTAATAGCCAGGGGCTACAGGCATATACCACCATGCCCAACTAATTTTTTAATTTTTTGTAGAGATGAGTGTCACTATG
TTGCCCAGGCTTGCCTGGAACTCCTAGCCTCAAGCAGTCTTCTTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTCCA
CCCAGCCCAGATTAAATGTTTTTATTTCTACCTGCCATCATTGGTCTTTACTAAGTGAAGTGACTTCTTTCTTTAACAATAAATAGAATT

>In-frame_ENST00000277817_ENST00000378624_TCGA-FD-A3SJ_HERC4_chr10_69792534_-_CDKAL1_chr6_21000457_length(amino acids)=404AA_start in transcript=495_stop in transcript=1709
MCVDSLVRICSGLSYGRIRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGA
HSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEMAKILNHPRVYAFLHIPVQSASDSVLMEMK
REYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVIGERQQVLVTEE
SFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSHTSAA

--------------------------------------------------------------
>In-frame_ENST00000277817_ENST00000378610_TCGA-FD-A3SJ_HERC4_chr10_69792534_-_CDKAL1_chr6_21000457_length(transcript)=3138nt_BP=942nt
GTGGTTAGTAGCGATAAATGCTCTGAAGGAAAAAACATACAGTACTGTGAGAATGTAGTATTTTGAAATGTTTCATTTGCAAAATTGTAC
TTGATACTCAGAATAGTGTTTTTTTTTCCTAAAATACTTAATATGCTGAACAGGTCAATGTATCATCTGCCTAGTATGCATAAACAATAA
CAGTAAATGTTTAGTAATTTGAGCACAGTTGGGTATGTTCATGTATTTTTTATTCCTTACTCTGTTTGCATTGCCAGTGTTTGATTTTGC
TATTTCAAAGAAATGGCATTTTGTTGAGTTTGAAAATTTGAAGGTGCATTGGATCCTGCTAATTTGTTGGATTCTGCTAAATTGTAGCAG
TACAGCTCTCAGGTTTTGTAGTTAAGAGCATAACTTCACTAAATAAAAATATTTTTAATACAATAATATGGAATCAGAGTAACTCTCCTT
TTTCCTGCTCAAACTTTGATTTGCTGAAGCTGCTTCCCGAAAATCATGTGTGTCGACTCTCTGGTCAGAATTTGCTCCGGACTCTCTTAT
GGCAGAATCAGAAATATTAAAAGTTTGTCAGATATCCAGATTGTACAGGTTGCTTGTGGTTACTATCATTCACTTGCACTTTCTAAAGCA
AGTGAAGTCTTCTGTTGGGGACAGAATAAATATGGCCAATTGGGTTTAGGTACTGACTGTAAAAAGCAAACTTCACCGCAGCTGCTTAAG
TCTTTGCTTGGAATCCCTTTCATGCAAGTTGCAGCAGGAGGAGCCCATAGTTTTGTACTCACCCTTTCTGGAGCTATCTTTGGATGGGGA
CGCAACAAGTTTGGTCAGCTAGGTCTTAATGATGAAAATGATAGGTATGTTCCTAATTTACTAAAGTCACTAAGATCTCAGAAAATAGTT
TATATTTGTTGTGGAGAAGATCATACTGCTGCTCTAACCAAGGAAATGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCAC
ATACCAGTCCAGTCTGCCTCCGACAGCGTACTCATGGAAATGAAAAGAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTG
AAAGAGAAAGTTCCTGGAATAACTATTGCTACAGATATTATCTGTGGTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAA
CTTGTTGAAGAGTACAAATTCCCAAGCCTGTTTATTAACCAATTTTACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCA
GCACAAGTGAAAAAGCAAAGGACAAAAGATCTTTCTCGGGTGTTTCATTCTTACAGTCCATATGATCACAAGATTGGTGAAAGACAACAA
GTGTTAGTAACAGAAGAATCTTTTGATTCCAAGTTTTATGTTGCACACAATCAATTCTATGAGCAGGTTTTAGTGCCAAAGAACCCTGCG
TTCATGGGGAAGATGGTTGAAGTGGACATCTATGAATCAGGCAAACATTTTATGAAAGGGCAGCCAGTATCTGATGCCAAAGTGTACACG
CCCTCCATCAGCAAACCGCTAGCAAAGGGAGAAGTCTCGGGTTTGACAAAGGACTTCAGAAATGGGCTTGGGAACCAGCTGAGTTCAGGA
TCCCACACCTCTGCTGCATCTCAGTGTGACTCAGCGAGTTCCAGAATGGTGCTGCCCATGCCAAGGCTACATCAAGACTGTGCGCTGAGG
ATGTCCGTGGGCTTGGCTCTGCTGGGTCTTCTTTTTGCTTTTTTTGTCAAGGTCTATAATTAGAATACAACTAATGGAAACATCTATAAA
GAAGAATACATTTCTAATTAAAATCTTCAATGAACAGGAAAGCGACATCTCCATTCTCCAAGGGCAATAATTTGTACTGGTCATGCTGCC
TCCTTCTCAGCCACTCTTCTTAATGAGGCTCCCCCTGTCTCACATTGAGTTGGGCCCATTGGTTATTTGACCTAAAACCTAATCACCGCT
ACCATAGCACATCCTTCAAATTAAACTGCTTTTGGTTTACTTTTAGCAAGAAATGCAAGCGGTTGCATTTTTTTCTGTTTGTTTCAATCT
CTAATCTTTAAGTCAGAACCTAATTGTACAGTGGCTCTGGCCATCTTTTCCTCATGTGGAAGAATTTTCTATCTTTAATAAACTTTTTCT
TTGTTTTTTTTTTCCAGATGGAGTTTCGCTCTTGTCCCCCAGGCTGGAGTGGTGCAGTGGCACGATCTCAGGTCACTGCAACCTCTGCCT
CCTGGGTTCAAACGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCATGCGCCACCAAGCCCAGACAATTTTTTTGTGTTT
TCAGTAGAGACGGAGTTTCACCATGTTGGCCAGGCTAGTCTCGAACTCCTGACCTCAAGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCT
AGGATTACAGGCGTGAGCCACTGCGCCCGGCCTCTTTAATAAATATTTTTAAGTGCATCTTCCCCTTCAGGCTTTGTTTGGAGTCCCAGT
GCTACAAACATTGTATTTTTCACAGCAGATGTGTTCCTGAAAAGTGTATAGAAACCTGTTCTGGGAACCTGAATGCTTTTGGAATGCACG
GGGAGAGTCTGCCAGCTAAAGGACTCCTGGCAACATTCTGTGAAATATGAAACTGGAAAACTGGATTTGTCGAAAACTAATTGTGCCCAT
TTTCTCACATTTTTGATCCATTGGGGTTTTTTTTTTGTTTTTGTTTTTTTTTTTTTTTGAGTCAAGGTCTCACTCTGTCACCCTGGCTGG
AGTGCAATGGCACTATCTTGGCTCACTGCAGCCTTGACCTCCTGGACTCAAGCAGTCCTCCTACCTCAGCCTCCCTAATAGCCAGGGGCT
ACAGGCATATACCACCATGCCCAACTAATTTTTTAATTTTTTGTAGAGATGAGTGTCACTATGTTGCCCAGGCTTGCCTGGAACTCCTAG
CCTCAAGCAGTCTTCTTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTCCACCCAGCCCAGATTAAATGTTTTTATTT

>In-frame_ENST00000277817_ENST00000378610_TCGA-FD-A3SJ_HERC4_chr10_69792534_-_CDKAL1_chr6_21000457_length(amino acids)=425AA_start in transcript=495_stop in transcript=1772
MCVDSLVRICSGLSYGRIRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGA
HSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEMAKILNHPRVYAFLHIPVQSASDSVLMEMK
REYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVF
HSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for HERC4-CDKAL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for HERC4-CDKAL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for HERC4-CDKAL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCDKAL1C0011860Diabetes Mellitus, Non-Insulin-Dependent3CTD_human
TgeneCDKAL1C0005910Body Weight2CTD_human
TgeneCDKAL1C0005612Birth Weight1CTD_human
TgeneCDKAL1C0263859Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome1CTD_human