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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:HIRA-ZBTB16 (FusionGDB2 ID:36308)

Fusion Gene Summary for HIRA-ZBTB16

check button Fusion gene summary
Fusion gene informationFusion gene name: HIRA-ZBTB16
Fusion gene ID: 36308
HgeneTgene
Gene symbol

HIRA

ZBTB16

Gene ID

7290

7704

Gene namehistone cell cycle regulatorzinc finger and BTB domain containing 16
SynonymsDGCR1|TUP1|TUPLE1PLZF|ZNF145
Cytomap

22q11.21

11q23.2

Type of geneprotein-codingprotein-coding
Descriptionprotein HIRADiGeorge critical region gene 1HIR histone cell cycle regulation defective homolog ATUP1-like enhancer of split protein 1histone regulator Azinc finger and BTB domain-containing protein 16promyelocytic leukaemia zinc fingerzinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)zinc finger protein PLZF
Modification date2020031320200329
UniProtAcc

P54198

.
Ensembl transtripts involved in fusion geneENST00000340170, ENST00000263208, 
ENST00000541063, ENST00000546308, 
ENST00000464189, 		ENST00000335953, 
ENST00000392996, ENST00000535379, 
Fusion gene scores* DoF score18 X 15 X 9=24308 X 10 X 2=160
# samples 2310
** MAII scorelog2(23/2430*10)=-3.40125054754877
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/160*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HIRA [Title/Abstract] AND ZBTB16 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHIRA(19384310)-ZBTB16(114027059), # samples:3
Anticipated loss of major functional domain due to fusion event.HIRA-ZBTB16 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
HIRA-ZBTB16 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HIRA-ZBTB16 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
HIRA-ZBTB16 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
HIRA-ZBTB16 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
HIRA-ZBTB16 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
HIRA-ZBTB16 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
HIRA-ZBTB16 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHIRA

GO:0006336

DNA replication-independent nucleosome assembly

14718166

TgeneZBTB16

GO:0000122

negative regulation of transcription by RNA polymerase II

12802276

TgeneZBTB16

GO:0030097

hemopoiesis

8541544

TgeneZBTB16

GO:0045778

positive regulation of ossification

21547890

TgeneZBTB16

GO:0045892

negative regulation of transcription, DNA-templated

12802276|24359566

TgeneZBTB16

GO:0045893

positive regulation of transcription, DNA-templated

21547890

TgeneZBTB16

GO:0051216

cartilage development

21547890

TgeneZBTB16

GO:0061036

positive regulation of cartilage development

21547890


check buttonFusion gene breakpoints across HIRA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ZBTB16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-7686-01AHIRAchr22

19384310

-ZBTB16chr11

114027059

+
ChimerDB4LGGTCGA-HT-7686HIRAchr22

19384309

-ZBTB16chr11

114027058

+
ChimerDB4LGGTCGA-HT-7686HIRAchr22

19384310

-ZBTB16chr11

114027059

+
ChimerDB4LGGTCGA-HT-7686-01AHIRAchr22

19384310

-ZBTB16chr11

114027059

+


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Fusion Gene ORF analysis for HIRA-ZBTB16

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000340170ENST00000335953HIRAchr22

19384310

-ZBTB16chr11

114027059

+
Frame-shiftENST00000340170ENST00000392996HIRAchr22

19384310

-ZBTB16chr11

114027059

+
5CDS-intronENST00000340170ENST00000535379HIRAchr22

19384310

-ZBTB16chr11

114027059

+
Frame-shiftENST00000263208ENST00000335953HIRAchr22

19384310

-ZBTB16chr11

114027059

+
Frame-shiftENST00000263208ENST00000392996HIRAchr22

19384310

-ZBTB16chr11

114027059

+
5CDS-intronENST00000263208ENST00000535379HIRAchr22

19384310

-ZBTB16chr11

114027059

+
Frame-shiftENST00000541063ENST00000335953HIRAchr22

19384310

-ZBTB16chr11

114027059

+
Frame-shiftENST00000541063ENST00000392996HIRAchr22

19384310

-ZBTB16chr11

114027059

+
5CDS-intronENST00000541063ENST00000535379HIRAchr22

19384310

-ZBTB16chr11

114027059

+
In-frameENST00000546308ENST00000335953HIRAchr22

19384310

-ZBTB16chr11

114027059

+
In-frameENST00000546308ENST00000392996HIRAchr22

19384310

-ZBTB16chr11

114027059

+
5CDS-intronENST00000546308ENST00000535379HIRAchr22

19384310

-ZBTB16chr11

114027059

+
intron-3CDSENST00000464189ENST00000335953HIRAchr22

19384310

-ZBTB16chr11

114027059

+
intron-3CDSENST00000464189ENST00000392996HIRAchr22

19384310

-ZBTB16chr11

114027059

+
intron-intronENST00000464189ENST00000535379HIRAchr22

19384310

-ZBTB16chr11

114027059

+
Frame-shiftENST00000340170ENST00000335953HIRAchr22

19384309

-ZBTB16chr11

114027058

+
Frame-shiftENST00000340170ENST00000392996HIRAchr22

19384309

-ZBTB16chr11

114027058

+
5CDS-intronENST00000340170ENST00000535379HIRAchr22

19384309

-ZBTB16chr11

114027058

+
Frame-shiftENST00000263208ENST00000335953HIRAchr22

19384309

-ZBTB16chr11

114027058

+
Frame-shiftENST00000263208ENST00000392996HIRAchr22

19384309

-ZBTB16chr11

114027058

+
5CDS-intronENST00000263208ENST00000535379HIRAchr22

19384309

-ZBTB16chr11

114027058

+
Frame-shiftENST00000541063ENST00000335953HIRAchr22

19384309

-ZBTB16chr11

114027058

+
Frame-shiftENST00000541063ENST00000392996HIRAchr22

19384309

-ZBTB16chr11

114027058

+
5CDS-intronENST00000541063ENST00000535379HIRAchr22

19384309

-ZBTB16chr11

114027058

+
In-frameENST00000546308ENST00000335953HIRAchr22

19384309

-ZBTB16chr11

114027058

+
In-frameENST00000546308ENST00000392996HIRAchr22

19384309

-ZBTB16chr11

114027058

+
5CDS-intronENST00000546308ENST00000535379HIRAchr22

19384309

-ZBTB16chr11

114027058

+
intron-3CDSENST00000464189ENST00000335953HIRAchr22

19384309

-ZBTB16chr11

114027058

+
intron-3CDSENST00000464189ENST00000392996HIRAchr22

19384309

-ZBTB16chr11

114027058

+
intron-intronENST00000464189ENST00000535379HIRAchr22

19384309

-ZBTB16chr11

114027058

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000546308HIRAchr2219384310-ENST00000335953ZBTB16chr11114027059+168781220874284
ENST00000546308HIRAchr2219384310-ENST00000392996ZBTB16chr11114027059+166381220874284
ENST00000546308HIRAchr2219384309-ENST00000335953ZBTB16chr11114027058+168781220874284
ENST00000546308HIRAchr2219384309-ENST00000392996ZBTB16chr11114027058+166381220874284

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000546308ENST00000335953HIRAchr2219384310-ZBTB16chr11114027059+0.0687202440.9312798
ENST00000546308ENST00000392996HIRAchr2219384310-ZBTB16chr11114027059+0.068094420.9319056
ENST00000546308ENST00000335953HIRAchr2219384309-ZBTB16chr11114027058+0.0687202440.9312798
ENST00000546308ENST00000392996HIRAchr2219384309-ZBTB16chr11114027058+0.068094420.9319056

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Fusion Genomic Features for HIRA-ZBTB16


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HIRAchr2219384309-ZBTB16chr11114027058+0.0315369480.96846306
HIRAchr2219384309-ZBTB16chr11114027058+0.0315369480.96846306
HIRAchr2219384309-ZBTB16chr11114027058+0.0315369480.96846306
HIRAchr2219384309-ZBTB16chr11114027058+0.0315369480.96846306

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HIRA-ZBTB16


check button Go to

FGviewer for the breakpoints of chr22:19384310-chr11:114027059

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HIRA

P54198

.
FUNCTION: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIRAchr22:19384309chr11:114027058ENST00000263208-72511_53218.01018.0RepeatNote=WD 1
HgeneHIRAchr22:19384309chr11:114027058ENST00000263208-725129_168218.01018.0RepeatNote=WD 3
HgeneHIRAchr22:19384309chr11:114027058ENST00000263208-725172_211218.01018.0RepeatNote=WD 4
HgeneHIRAchr22:19384309chr11:114027058ENST00000263208-72568_107218.01018.0RepeatNote=WD 2
HgeneHIRAchr22:19384309chr11:114027058ENST00000340170-72111_53218.0811.0RepeatNote=WD 1
HgeneHIRAchr22:19384309chr11:114027058ENST00000340170-721129_168218.0811.0RepeatNote=WD 3
HgeneHIRAchr22:19384309chr11:114027058ENST00000340170-721172_211218.0811.0RepeatNote=WD 4
HgeneHIRAchr22:19384309chr11:114027058ENST00000340170-72168_107218.0811.0RepeatNote=WD 2
HgeneHIRAchr22:19384310chr11:114027059ENST00000263208-72511_53218.01018.0RepeatNote=WD 1
HgeneHIRAchr22:19384310chr11:114027059ENST00000263208-725129_168218.01018.0RepeatNote=WD 3
HgeneHIRAchr22:19384310chr11:114027059ENST00000263208-725172_211218.01018.0RepeatNote=WD 4
HgeneHIRAchr22:19384310chr11:114027059ENST00000263208-72568_107218.01018.0RepeatNote=WD 2
HgeneHIRAchr22:19384310chr11:114027059ENST00000340170-72111_53218.0811.0RepeatNote=WD 1
HgeneHIRAchr22:19384310chr11:114027059ENST00000340170-721129_168218.0811.0RepeatNote=WD 3
HgeneHIRAchr22:19384310chr11:114027059ENST00000340170-721172_211218.0811.0RepeatNote=WD 4
HgeneHIRAchr22:19384310chr11:114027059ENST00000340170-72168_107218.0811.0RepeatNote=WD 2
TgeneZBTB16chr22:19384309chr11:114027058ENST0000033595317432_454422.6666666666667674.0Zinc fingerC2H2-type 2
TgeneZBTB16chr22:19384309chr11:114027058ENST0000033595317461_483422.6666666666667674.0Zinc fingerC2H2-type 3
TgeneZBTB16chr22:19384309chr11:114027058ENST0000033595317490_512422.6666666666667674.0Zinc fingerC2H2-type 4
TgeneZBTB16chr22:19384309chr11:114027058ENST0000033595317518_540422.6666666666667674.0Zinc fingerC2H2-type 5
TgeneZBTB16chr22:19384309chr11:114027058ENST0000033595317546_568422.6666666666667674.0Zinc fingerC2H2-type 6
TgeneZBTB16chr22:19384309chr11:114027058ENST0000033595317574_596422.6666666666667674.0Zinc fingerC2H2-type 7
TgeneZBTB16chr22:19384309chr11:114027058ENST0000033595317602_624422.6666666666667674.0Zinc fingerC2H2-type 8
TgeneZBTB16chr22:19384309chr11:114027058ENST0000033595317630_652422.6666666666667674.0Zinc fingerC2H2-type 9
TgeneZBTB16chr22:19384309chr11:114027058ENST0000039299617432_454422.6666666666667674.0Zinc fingerC2H2-type 2
TgeneZBTB16chr22:19384309chr11:114027058ENST0000039299617461_483422.6666666666667674.0Zinc fingerC2H2-type 3
TgeneZBTB16chr22:19384309chr11:114027058ENST0000039299617490_512422.6666666666667674.0Zinc fingerC2H2-type 4
TgeneZBTB16chr22:19384309chr11:114027058ENST0000039299617518_540422.6666666666667674.0Zinc fingerC2H2-type 5
TgeneZBTB16chr22:19384309chr11:114027058ENST0000039299617546_568422.6666666666667674.0Zinc fingerC2H2-type 6
TgeneZBTB16chr22:19384309chr11:114027058ENST0000039299617574_596422.6666666666667674.0Zinc fingerC2H2-type 7
TgeneZBTB16chr22:19384309chr11:114027058ENST0000039299617602_624422.6666666666667674.0Zinc fingerC2H2-type 8
TgeneZBTB16chr22:19384309chr11:114027058ENST0000039299617630_652422.6666666666667674.0Zinc fingerC2H2-type 9
TgeneZBTB16chr22:19384310chr11:114027059ENST0000033595317432_454422.6666666666667674.0Zinc fingerC2H2-type 2
TgeneZBTB16chr22:19384310chr11:114027059ENST0000033595317461_483422.6666666666667674.0Zinc fingerC2H2-type 3
TgeneZBTB16chr22:19384310chr11:114027059ENST0000033595317490_512422.6666666666667674.0Zinc fingerC2H2-type 4
TgeneZBTB16chr22:19384310chr11:114027059ENST0000033595317518_540422.6666666666667674.0Zinc fingerC2H2-type 5
TgeneZBTB16chr22:19384310chr11:114027059ENST0000033595317546_568422.6666666666667674.0Zinc fingerC2H2-type 6
TgeneZBTB16chr22:19384310chr11:114027059ENST0000033595317574_596422.6666666666667674.0Zinc fingerC2H2-type 7
TgeneZBTB16chr22:19384310chr11:114027059ENST0000033595317602_624422.6666666666667674.0Zinc fingerC2H2-type 8
TgeneZBTB16chr22:19384310chr11:114027059ENST0000033595317630_652422.6666666666667674.0Zinc fingerC2H2-type 9
TgeneZBTB16chr22:19384310chr11:114027059ENST0000039299617432_454422.6666666666667674.0Zinc fingerC2H2-type 2
TgeneZBTB16chr22:19384310chr11:114027059ENST0000039299617461_483422.6666666666667674.0Zinc fingerC2H2-type 3
TgeneZBTB16chr22:19384310chr11:114027059ENST0000039299617490_512422.6666666666667674.0Zinc fingerC2H2-type 4
TgeneZBTB16chr22:19384310chr11:114027059ENST0000039299617518_540422.6666666666667674.0Zinc fingerC2H2-type 5
TgeneZBTB16chr22:19384310chr11:114027059ENST0000039299617546_568422.6666666666667674.0Zinc fingerC2H2-type 6
TgeneZBTB16chr22:19384310chr11:114027059ENST0000039299617574_596422.6666666666667674.0Zinc fingerC2H2-type 7
TgeneZBTB16chr22:19384310chr11:114027059ENST0000039299617602_624422.6666666666667674.0Zinc fingerC2H2-type 8
TgeneZBTB16chr22:19384310chr11:114027059ENST0000039299617630_652422.6666666666667674.0Zinc fingerC2H2-type 9

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIRAchr22:19384309chr11:114027058ENST00000263208-725408_412218.01018.0Compositional biasNote=Poly-Gln
HgeneHIRAchr22:19384309chr11:114027058ENST00000263208-725640_643218.01018.0Compositional biasNote=Poly-Lys
HgeneHIRAchr22:19384309chr11:114027058ENST00000263208-725805_808218.01018.0Compositional biasNote=Poly-Val
HgeneHIRAchr22:19384309chr11:114027058ENST00000340170-721408_412218.0811.0Compositional biasNote=Poly-Gln
HgeneHIRAchr22:19384309chr11:114027058ENST00000340170-721640_643218.0811.0Compositional biasNote=Poly-Lys
HgeneHIRAchr22:19384309chr11:114027058ENST00000340170-721805_808218.0811.0Compositional biasNote=Poly-Val
HgeneHIRAchr22:19384310chr11:114027059ENST00000263208-725408_412218.01018.0Compositional biasNote=Poly-Gln
HgeneHIRAchr22:19384310chr11:114027059ENST00000263208-725640_643218.01018.0Compositional biasNote=Poly-Lys
HgeneHIRAchr22:19384310chr11:114027059ENST00000263208-725805_808218.01018.0Compositional biasNote=Poly-Val
HgeneHIRAchr22:19384310chr11:114027059ENST00000340170-721408_412218.0811.0Compositional biasNote=Poly-Gln
HgeneHIRAchr22:19384310chr11:114027059ENST00000340170-721640_643218.0811.0Compositional biasNote=Poly-Lys
HgeneHIRAchr22:19384310chr11:114027059ENST00000340170-721805_808218.0811.0Compositional biasNote=Poly-Val
HgeneHIRAchr22:19384309chr11:114027058ENST00000263208-725439_475218.01018.0RegionNote=Required for repression of histone gene transcription
HgeneHIRAchr22:19384309chr11:114027058ENST00000340170-721439_475218.0811.0RegionNote=Required for repression of histone gene transcription
HgeneHIRAchr22:19384310chr11:114027059ENST00000263208-725439_475218.01018.0RegionNote=Required for repression of histone gene transcription
HgeneHIRAchr22:19384310chr11:114027059ENST00000340170-721439_475218.0811.0RegionNote=Required for repression of histone gene transcription
HgeneHIRAchr22:19384309chr11:114027058ENST00000263208-725220_263218.01018.0RepeatNote=WD 5
HgeneHIRAchr22:19384309chr11:114027058ENST00000263208-725266_322218.01018.0RepeatNote=WD 6
HgeneHIRAchr22:19384309chr11:114027058ENST00000263208-725326_367218.01018.0RepeatNote=WD 7
HgeneHIRAchr22:19384309chr11:114027058ENST00000340170-721220_263218.0811.0RepeatNote=WD 5
HgeneHIRAchr22:19384309chr11:114027058ENST00000340170-721266_322218.0811.0RepeatNote=WD 6
HgeneHIRAchr22:19384309chr11:114027058ENST00000340170-721326_367218.0811.0RepeatNote=WD 7
HgeneHIRAchr22:19384310chr11:114027059ENST00000263208-725220_263218.01018.0RepeatNote=WD 5
HgeneHIRAchr22:19384310chr11:114027059ENST00000263208-725266_322218.01018.0RepeatNote=WD 6
HgeneHIRAchr22:19384310chr11:114027059ENST00000263208-725326_367218.01018.0RepeatNote=WD 7
HgeneHIRAchr22:19384310chr11:114027059ENST00000340170-721220_263218.0811.0RepeatNote=WD 5
HgeneHIRAchr22:19384310chr11:114027059ENST00000340170-721266_322218.0811.0RepeatNote=WD 6
HgeneHIRAchr22:19384310chr11:114027059ENST00000340170-721326_367218.0811.0RepeatNote=WD 7
TgeneZBTB16chr22:19384309chr11:114027058ENST000003359531734_96422.6666666666667674.0DomainBTB
TgeneZBTB16chr22:19384309chr11:114027058ENST000003929961734_96422.6666666666667674.0DomainBTB
TgeneZBTB16chr22:19384310chr11:114027059ENST000003359531734_96422.6666666666667674.0DomainBTB
TgeneZBTB16chr22:19384310chr11:114027059ENST000003929961734_96422.6666666666667674.0DomainBTB
TgeneZBTB16chr22:19384309chr11:114027058ENST0000033595317404_426422.6666666666667674.0Zinc fingerC2H2-type 1
TgeneZBTB16chr22:19384309chr11:114027058ENST0000039299617404_426422.6666666666667674.0Zinc fingerC2H2-type 1
TgeneZBTB16chr22:19384310chr11:114027059ENST0000033595317404_426422.6666666666667674.0Zinc fingerC2H2-type 1
TgeneZBTB16chr22:19384310chr11:114027059ENST0000039299617404_426422.6666666666667674.0Zinc fingerC2H2-type 1


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Fusion Gene Sequence for HIRA-ZBTB16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000546308_ENST00000335953_TCGA-HT-7686-01A_HIRA_chr22_19384310_-_ZBTB16_chr11_114027059_length(transcript)=1687nt_BP=812nt
GACATGGCGGACGGCAGCGGCTGGCAGCCGCCGCGCCCCTGCGAGGCCTACCGCGCCGAGTGGAAGCTCTGCCGCAGCGCCAGGCACTTC
CTACACCACTACTACGTCCACGGCGAGCGGCCGGCCTGCGAACAGTGGCAGCGCGACCTGGCCAGCTGCCGCGACTGGGAGGAGCGCCGG
AACGCCGAGGCCCAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACTGGAGGACAAGGGCAGGATTCTG
GGAAGGTTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCCAAGATGCTTTGCCAGATGGACA
ATCACTTAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGATGACAAACTGATTATGGTGTGGA
AGCGGGCTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAGTGGCGGTGTGTCTCTATCCTCC
GGAATCATTCAGGCGATGTGATGGATGTAGCATGGTCTCCCCACGATGCCTGGCTAGCCTCATGCAGCGTGGATAACACTGTCGTCATCT
GGAATGCTGTAAAGTTCCCAGAAATTCTAGCTACTCTGAGAGGTCATTCTGGCTTGGTCAAAGGGTTGACATGGGACCCTGTTGGTAAAT
ACATAGCTTCTCAAGCTGATGACCGCAGCCTAAAGGTGTGGAGGACGCTGGACTGGCAGTTGGAGACCAGCATCACCAAGCCTTTTGATG
AGGAAGCTGCACAGTGGGATGAAGACGTACGGGTGCGAGCTCTGCGGGAAGCGGTTCCTGGATAGTTTGCGGCTGAGAATGCACTTACTG
GCTCATTCAGCGGGTGCCAAAGCCTTTGTCTGTGATCAGTGCGGTGCACAGTTTTCGAAGGAGGATGCCCTGGAGACACACAGGCAGACC
CATACTGGCACTGACATGGCCGTCTTCTGTCTGCTGTGTGGGAAGCGCTTCCAGGCGCAGAGCGCACTGCAGCAGCACATGGAGGTCCAC
GCGGGCGTGCGCAGCTACATCTGCAGTGAGTGCAACCGCACCTTCCCCAGCCACACGGCTCTCAAACGCCACCTGCGCTCACATACAGGC
GACCACCCCTACGAGTGTGAGTTCTGTGGCAGCTGCTTCCGGGATGAGAGCACACTCAAGAGCCACAAACGCATCCACACGGGTGAGAAA
CCCTACGAGTGCAATGGCTGTGGCAAGAAGTTCAGCCTCAAGCATCAGCTGGAGACGCACTATAGGGTGCACACAGGTGAGAAGCCCTTT
GAGTGTAAGCTCTGCCACCAGCGCTCCCGGGACTACTCGGCCATGATCAAGCACCTGAGAACGCACAACGGCGCCTCGCCCTACCAGTGC
ACCATCTGCACAGAGTACTGCCCCAGCCTCTCCTCCATGCAGAAGCACATGAAGGGCCACAAGCCCGAGGAGATCCCGCCCGACTGGAGG
ATAGAGAAGACGTACCTCTACCTGTGCTATGTGTGAAGGGAGGCCCGCGGCGGTGGAGCCGAGCGGGGAGCCAGGAAAGAAGAGTTGGAG

>In-frame_ENST00000546308_ENST00000335953_TCGA-HT-7686-01A_HIRA_chr22_19384310_-_ZBTB16_chr11_114027059_length(amino acids)=284AA_start in transcript=20_stop in transcript=874
MAAAAPLRGLPRRVEALPQRQALPTPLLRPRRAAGLRTVAARPGQLPRLGGAPERRGPGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWN
MSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDV
MDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDEEAAQWD

--------------------------------------------------------------
>In-frame_ENST00000546308_ENST00000392996_TCGA-HT-7686-01A_HIRA_chr22_19384310_-_ZBTB16_chr11_114027059_length(transcript)=1663nt_BP=812nt
GACATGGCGGACGGCAGCGGCTGGCAGCCGCCGCGCCCCTGCGAGGCCTACCGCGCCGAGTGGAAGCTCTGCCGCAGCGCCAGGCACTTC
CTACACCACTACTACGTCCACGGCGAGCGGCCGGCCTGCGAACAGTGGCAGCGCGACCTGGCCAGCTGCCGCGACTGGGAGGAGCGCCGG
AACGCCGAGGCCCAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACTGGAGGACAAGGGCAGGATTCTG
GGAAGGTTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCCAAGATGCTTTGCCAGATGGACA
ATCACTTAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGATGACAAACTGATTATGGTGTGGA
AGCGGGCTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAGTGGCGGTGTGTCTCTATCCTCC
GGAATCATTCAGGCGATGTGATGGATGTAGCATGGTCTCCCCACGATGCCTGGCTAGCCTCATGCAGCGTGGATAACACTGTCGTCATCT
GGAATGCTGTAAAGTTCCCAGAAATTCTAGCTACTCTGAGAGGTCATTCTGGCTTGGTCAAAGGGTTGACATGGGACCCTGTTGGTAAAT
ACATAGCTTCTCAAGCTGATGACCGCAGCCTAAAGGTGTGGAGGACGCTGGACTGGCAGTTGGAGACCAGCATCACCAAGCCTTTTGATG
AGGAAGCTGCACAGTGGGATGAAGACGTACGGGTGCGAGCTCTGCGGGAAGCGGTTCCTGGATAGTTTGCGGCTGAGAATGCACTTACTG
GCTCATTCAGCGGGTGCCAAAGCCTTTGTCTGTGATCAGTGCGGTGCACAGTTTTCGAAGGAGGATGCCCTGGAGACACACAGGCAGACC
CATACTGGCACTGACATGGCCGTCTTCTGTCTGCTGTGTGGGAAGCGCTTCCAGGCGCAGAGCGCACTGCAGCAGCACATGGAGGTCCAC
GCGGGCGTGCGCAGCTACATCTGCAGTGAGTGCAACCGCACCTTCCCCAGCCACACGGCTCTCAAACGCCACCTGCGCTCACATACAGGC
GACCACCCCTACGAGTGTGAGTTCTGTGGCAGCTGCTTCCGGGATGAGAGCACACTCAAGAGCCACAAACGCATCCACACGGGTGAGAAA
CCCTACGAGTGCAATGGCTGTGGCAAGAAGTTCAGCCTCAAGCATCAGCTGGAGACGCACTATAGGGTGCACACAGGTGAGAAGCCCTTT
GAGTGTAAGCTCTGCCACCAGCGCTCCCGGGACTACTCGGCCATGATCAAGCACCTGAGAACGCACAACGGCGCCTCGCCCTACCAGTGC
ACCATCTGCACAGAGTACTGCCCCAGCCTCTCCTCCATGCAGAAGCACATGAAGGGCCACAAGCCCGAGGAGATCCCGCCCGACTGGAGG
ATAGAGAAGACGTACCTCTACCTGTGCTATGTGTGAAGGGAGGCCCGCGGCGGTGGAGCCGAGCGGGGAGCCAGGAAAGAAGAGTTGGAG

>In-frame_ENST00000546308_ENST00000392996_TCGA-HT-7686-01A_HIRA_chr22_19384310_-_ZBTB16_chr11_114027059_length(amino acids)=284AA_start in transcript=20_stop in transcript=874
MAAAAPLRGLPRRVEALPQRQALPTPLLRPRRAAGLRTVAARPGQLPRLGGAPERRGPGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWN
MSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDV
MDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDEEAAQWD

--------------------------------------------------------------
>In-frame_ENST00000546308_ENST00000335953_TCGA-HT-7686_HIRA_chr22_19384309_-_ZBTB16_chr11_114027058_length(transcript)=1687nt_BP=812nt
GACATGGCGGACGGCAGCGGCTGGCAGCCGCCGCGCCCCTGCGAGGCCTACCGCGCCGAGTGGAAGCTCTGCCGCAGCGCCAGGCACTTC
CTACACCACTACTACGTCCACGGCGAGCGGCCGGCCTGCGAACAGTGGCAGCGCGACCTGGCCAGCTGCCGCGACTGGGAGGAGCGCCGG
AACGCCGAGGCCCAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACTGGAGGACAAGGGCAGGATTCTG
GGAAGGTTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCCAAGATGCTTTGCCAGATGGACA
ATCACTTAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGATGACAAACTGATTATGGTGTGGA
AGCGGGCTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAGTGGCGGTGTGTCTCTATCCTCC
GGAATCATTCAGGCGATGTGATGGATGTAGCATGGTCTCCCCACGATGCCTGGCTAGCCTCATGCAGCGTGGATAACACTGTCGTCATCT
GGAATGCTGTAAAGTTCCCAGAAATTCTAGCTACTCTGAGAGGTCATTCTGGCTTGGTCAAAGGGTTGACATGGGACCCTGTTGGTAAAT
ACATAGCTTCTCAAGCTGATGACCGCAGCCTAAAGGTGTGGAGGACGCTGGACTGGCAGTTGGAGACCAGCATCACCAAGCCTTTTGATG
AGGAAGCTGCACAGTGGGATGAAGACGTACGGGTGCGAGCTCTGCGGGAAGCGGTTCCTGGATAGTTTGCGGCTGAGAATGCACTTACTG
GCTCATTCAGCGGGTGCCAAAGCCTTTGTCTGTGATCAGTGCGGTGCACAGTTTTCGAAGGAGGATGCCCTGGAGACACACAGGCAGACC
CATACTGGCACTGACATGGCCGTCTTCTGTCTGCTGTGTGGGAAGCGCTTCCAGGCGCAGAGCGCACTGCAGCAGCACATGGAGGTCCAC
GCGGGCGTGCGCAGCTACATCTGCAGTGAGTGCAACCGCACCTTCCCCAGCCACACGGCTCTCAAACGCCACCTGCGCTCACATACAGGC
GACCACCCCTACGAGTGTGAGTTCTGTGGCAGCTGCTTCCGGGATGAGAGCACACTCAAGAGCCACAAACGCATCCACACGGGTGAGAAA
CCCTACGAGTGCAATGGCTGTGGCAAGAAGTTCAGCCTCAAGCATCAGCTGGAGACGCACTATAGGGTGCACACAGGTGAGAAGCCCTTT
GAGTGTAAGCTCTGCCACCAGCGCTCCCGGGACTACTCGGCCATGATCAAGCACCTGAGAACGCACAACGGCGCCTCGCCCTACCAGTGC
ACCATCTGCACAGAGTACTGCCCCAGCCTCTCCTCCATGCAGAAGCACATGAAGGGCCACAAGCCCGAGGAGATCCCGCCCGACTGGAGG
ATAGAGAAGACGTACCTCTACCTGTGCTATGTGTGAAGGGAGGCCCGCGGCGGTGGAGCCGAGCGGGGAGCCAGGAAAGAAGAGTTGGAG

>In-frame_ENST00000546308_ENST00000335953_TCGA-HT-7686_HIRA_chr22_19384309_-_ZBTB16_chr11_114027058_length(amino acids)=284AA_start in transcript=20_stop in transcript=874
MAAAAPLRGLPRRVEALPQRQALPTPLLRPRRAAGLRTVAARPGQLPRLGGAPERRGPGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWN
MSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDV
MDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDEEAAQWD

--------------------------------------------------------------
>In-frame_ENST00000546308_ENST00000392996_TCGA-HT-7686_HIRA_chr22_19384309_-_ZBTB16_chr11_114027058_length(transcript)=1663nt_BP=812nt
GACATGGCGGACGGCAGCGGCTGGCAGCCGCCGCGCCCCTGCGAGGCCTACCGCGCCGAGTGGAAGCTCTGCCGCAGCGCCAGGCACTTC
CTACACCACTACTACGTCCACGGCGAGCGGCCGGCCTGCGAACAGTGGCAGCGCGACCTGGCCAGCTGCCGCGACTGGGAGGAGCGCCGG
AACGCCGAGGCCCAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACTGGAGGACAAGGGCAGGATTCTG
GGAAGGTTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCCAAGATGCTTTGCCAGATGGACA
ATCACTTAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGATGACAAACTGATTATGGTGTGGA
AGCGGGCTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAGTGGCGGTGTGTCTCTATCCTCC
GGAATCATTCAGGCGATGTGATGGATGTAGCATGGTCTCCCCACGATGCCTGGCTAGCCTCATGCAGCGTGGATAACACTGTCGTCATCT
GGAATGCTGTAAAGTTCCCAGAAATTCTAGCTACTCTGAGAGGTCATTCTGGCTTGGTCAAAGGGTTGACATGGGACCCTGTTGGTAAAT
ACATAGCTTCTCAAGCTGATGACCGCAGCCTAAAGGTGTGGAGGACGCTGGACTGGCAGTTGGAGACCAGCATCACCAAGCCTTTTGATG
AGGAAGCTGCACAGTGGGATGAAGACGTACGGGTGCGAGCTCTGCGGGAAGCGGTTCCTGGATAGTTTGCGGCTGAGAATGCACTTACTG
GCTCATTCAGCGGGTGCCAAAGCCTTTGTCTGTGATCAGTGCGGTGCACAGTTTTCGAAGGAGGATGCCCTGGAGACACACAGGCAGACC
CATACTGGCACTGACATGGCCGTCTTCTGTCTGCTGTGTGGGAAGCGCTTCCAGGCGCAGAGCGCACTGCAGCAGCACATGGAGGTCCAC
GCGGGCGTGCGCAGCTACATCTGCAGTGAGTGCAACCGCACCTTCCCCAGCCACACGGCTCTCAAACGCCACCTGCGCTCACATACAGGC
GACCACCCCTACGAGTGTGAGTTCTGTGGCAGCTGCTTCCGGGATGAGAGCACACTCAAGAGCCACAAACGCATCCACACGGGTGAGAAA
CCCTACGAGTGCAATGGCTGTGGCAAGAAGTTCAGCCTCAAGCATCAGCTGGAGACGCACTATAGGGTGCACACAGGTGAGAAGCCCTTT
GAGTGTAAGCTCTGCCACCAGCGCTCCCGGGACTACTCGGCCATGATCAAGCACCTGAGAACGCACAACGGCGCCTCGCCCTACCAGTGC
ACCATCTGCACAGAGTACTGCCCCAGCCTCTCCTCCATGCAGAAGCACATGAAGGGCCACAAGCCCGAGGAGATCCCGCCCGACTGGAGG
ATAGAGAAGACGTACCTCTACCTGTGCTATGTGTGAAGGGAGGCCCGCGGCGGTGGAGCCGAGCGGGGAGCCAGGAAAGAAGAGTTGGAG

>In-frame_ENST00000546308_ENST00000392996_TCGA-HT-7686_HIRA_chr22_19384309_-_ZBTB16_chr11_114027058_length(amino acids)=284AA_start in transcript=20_stop in transcript=874
MAAAAPLRGLPRRVEALPQRQALPTPLLRPRRAAGLRTVAARPGQLPRLGGAPERRGPGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWN
MSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDV
MDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDEEAAQWD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HIRA-ZBTB16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneHIRAchr22:19384309chr11:114027058ENST00000263208-725421_479218.01018.0ASF1A
HgeneHIRAchr22:19384309chr11:114027058ENST00000340170-721421_479218.0811.0ASF1A
HgeneHIRAchr22:19384310chr11:114027059ENST00000263208-725421_479218.01018.0ASF1A
HgeneHIRAchr22:19384310chr11:114027059ENST00000340170-721421_479218.0811.0ASF1A
HgeneHIRAchr22:19384309chr11:114027058ENST00000263208-725421_729218.01018.0CCNA1
HgeneHIRAchr22:19384309chr11:114027058ENST00000340170-721421_729218.0811.0CCNA1
HgeneHIRAchr22:19384310chr11:114027059ENST00000263208-725421_729218.01018.0CCNA1
HgeneHIRAchr22:19384310chr11:114027059ENST00000340170-721421_729218.0811.0CCNA1
HgeneHIRAchr22:19384309chr11:114027058ENST00000263208-725593_826218.01018.0histone H2B
HgeneHIRAchr22:19384309chr11:114027058ENST00000340170-721593_826218.0811.0histone H2B
HgeneHIRAchr22:19384310chr11:114027059ENST00000263208-725593_826218.01018.0histone H2B
HgeneHIRAchr22:19384310chr11:114027059ENST00000340170-721593_826218.0811.0histone H2B
HgeneHIRAchr22:19384309chr11:114027058ENST00000263208-725738_1017218.01018.0histone H4
HgeneHIRAchr22:19384309chr11:114027058ENST00000340170-721738_1017218.0811.0histone H4
HgeneHIRAchr22:19384310chr11:114027059ENST00000263208-725738_1017218.01018.0histone H4
HgeneHIRAchr22:19384310chr11:114027059ENST00000340170-721738_1017218.0811.0histone H4
HgeneHIRAchr22:19384309chr11:114027058ENST00000263208-725594_739218.01018.0PAX3
HgeneHIRAchr22:19384309chr11:114027058ENST00000263208-725740_828218.01018.0PAX3
HgeneHIRAchr22:19384309chr11:114027058ENST00000340170-721594_739218.0811.0PAX3
HgeneHIRAchr22:19384309chr11:114027058ENST00000340170-721740_828218.0811.0PAX3
HgeneHIRAchr22:19384310chr11:114027059ENST00000263208-725594_739218.01018.0PAX3
HgeneHIRAchr22:19384310chr11:114027059ENST00000263208-725740_828218.01018.0PAX3
HgeneHIRAchr22:19384310chr11:114027059ENST00000340170-721594_739218.0811.0PAX3
HgeneHIRAchr22:19384310chr11:114027059ENST00000340170-721740_828218.0811.0PAX3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HIRA-ZBTB16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HIRA-ZBTB16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHIRAC0012236DiGeorge Syndrome1ORPHANET
HgeneHIRAC0220704Shprintzen syndrome1ORPHANET
HgeneHIRAC0431406Asymmetric crying face association1ORPHANET
HgeneHIRAC0795907CONOTRUNCAL ANOMALY FACE SYNDROME1ORPHANET
HgeneHIRAC293634622q11 Deletion Syndrome1ORPHANET
HgeneHIRAC326610122q11 partial monosomy syndrome1ORPHANET
TgeneZBTB16C0023487Acute Promyelocytic Leukemia3CTD_human;ORPHANET
TgeneZBTB16C0027626Neoplasm Invasiveness1CTD_human
TgeneZBTB16C0033578Prostatic Neoplasms1CTD_human
TgeneZBTB16C0041696Unipolar Depression1PSYGENET
TgeneZBTB16C0376358Malignant neoplasm of prostate1CTD_human
TgeneZBTB16C1269683Major Depressive Disorder1PSYGENET
TgeneZBTB16C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1ORPHANET
TgeneZBTB16C2676231Skeletal Defects, Genital Hypoplasia, And Mental Retardation1CTD_human;GENOMICS_ENGLAND;UNIPROT