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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HLA-A-HSP90AA1 (FusionGDB2 ID:36475)

Fusion Gene Summary for HLA-A-HSP90AA1

Fusion gene summary

Fusion gene information	Fusion gene name: HLA-A-HSP90AA1
	Fusion gene ID: 36475
		Hgene	Tgene
	Gene symbol	HLA-A	HSP90AA1
	Gene ID	3105	3320
	Gene name	major histocompatibility complex, class I, A	heat shock protein 90 alpha family class A member 1
	Synonyms	HLAA	EL52\|HEL-S-65p\|HSP86\|HSP89A\|HSP90A\|HSP90N\|HSPC1\|HSPCA\|HSPCAL1\|HSPCAL4\|HSPN\|Hsp103\|Hsp89\|Hsp90\|LAP-2\|LAP2
	Cytomap	6p22.1	14q32.31
	Type of gene	protein-coding	protein-coding
	Description	HLA class I histocompatibility antigen, A alpha chainHLA class I histocompatibility antigen, A-1 alpha chainMHC class I antigen HLA-A heavy chainleukocyte antigen class I-A	heat shock protein HSP 90-alphaHSP 86LPS-associated protein 2epididymis luminal secretory protein 52epididymis secretory sperm binding protein Li 65pheat shock 86 kDaheat shock 90kD protein 1, alphaheat shock 90kD protein 1, alpha-like 4heat shock
	Modification date	20200328	20200327
	UniProtAcc	P04439	P07900
	Ensembl transtripts involved in fusion gene	ENST00000396634, ENST00000376806, ENST00000376809, ENST00000376802, ENST00000431930, ENST00000444289, ENST00000551578, ENST00000551120, ENST00000552193, ENST00000416096, ENST00000443552, ENST00000417978, ENST00000547112, ENST00000552498, ENST00000549869, ENST00000442939, ENST00000457879, ENST00000438861, ENST00000547271, ENST00000453975, ENST00000547522, ENST00000383605, ENST00000383619, ENST00000549224, ENST00000376822, ENST00000456012, ENST00000550728, ENST00000450342, ENST00000454091, ENST00000488889, ENST00000552493, ENST00000414592,	ENST00000216281, ENST00000334701, ENST00000441629, ENST00000558600,
Fusion gene scores	* DoF score	11 X 11 X 3=363	30 X 32 X 8=7680
	# samples	11	42
	** MAII score	log2(11/363*10)=-1.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(42/7680*10)=-4.1926450779424 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HLA-A [Title/Abstract] AND HSP90AA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HLA-A(29912028)-HSP90AA1(102552707), # samples:1
Anticipated loss of major functional domain due to fusion event.	HLA-A-HSP90AA1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. HLA-A-HSP90AA1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. HLA-A-HSP90AA1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. HLA-A-HSP90AA1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HLA-A	GO:0001913	T cell mediated cytotoxicity	7504010
Hgene	HLA-A	GO:0002419	T cell mediated cytotoxicity directed against tumor cell target	1402688\|17189421\|20364150
Hgene	HLA-A	GO:0002726	positive regulation of T cell cytokine production	24643698
Hgene	HLA-A	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	1402688\|20364150\|24643698
Hgene	HLA-A	GO:0036037	CD8-positive, alpha-beta T cell activation	1402688\|2784196\|7504010\|8630735\|12138174\|17189421\|20364150
Hgene	HLA-A	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	7504010\|12138174
Hgene	HLA-A	GO:0050852	T cell receptor signaling pathway	10435578
Hgene	HLA-A	GO:2001187	positive regulation of CD8-positive, alpha-beta T cell activation	24643698
Tgene	HSP90AA1	GO:0001934	positive regulation of protein phosphorylation	19363271
Tgene	HSP90AA1	GO:0007004	telomere maintenance via telomerase	10197982
Tgene	HSP90AA1	GO:0031396	regulation of protein ubiquitination	16809764
Tgene	HSP90AA1	GO:0032273	positive regulation of protein polymerization	19363271
Tgene	HSP90AA1	GO:0045040	protein import into mitochondrial outer membrane	15644312
Tgene	HSP90AA1	GO:0051131	chaperone-mediated protein complex assembly	15644312
Tgene	HSP90AA1	GO:0051973	positive regulation of telomerase activity	10197982
Tgene	HSP90AA1	GO:1902949	positive regulation of tau-protein kinase activity	19363271
Tgene	HSP90AA1	GO:1905323	telomerase holoenzyme complex assembly	10197982

Fusion gene breakpoints across HLA-A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HSP90AA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CK003121	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-

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Fusion Gene ORF analysis for HLA-A-HSP90AA1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000396634	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
Frame-shift	ENST00000396634	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
5CDS-intron	ENST00000396634	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
5CDS-intron	ENST00000396634	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
Frame-shift	ENST00000376806	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
Frame-shift	ENST00000376806	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
5CDS-intron	ENST00000376806	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
5CDS-intron	ENST00000376806	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
Frame-shift	ENST00000376809	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
Frame-shift	ENST00000376809	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
5CDS-intron	ENST00000376809	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
5CDS-intron	ENST00000376809	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
Frame-shift	ENST00000376802	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
Frame-shift	ENST00000376802	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
5CDS-intron	ENST00000376802	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
5CDS-intron	ENST00000376802	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000431930	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000431930	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000431930	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000431930	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000444289	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000444289	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000444289	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000444289	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000551578	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000551578	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000551578	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000551578	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000551120	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000551120	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000551120	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000551120	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000552193	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000552193	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000552193	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000552193	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000416096	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000416096	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000416096	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000416096	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000443552	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000443552	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000443552	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000443552	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000417978	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000417978	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000417978	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000417978	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000547112	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000547112	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000547112	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000547112	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000552498	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000552498	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000552498	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000552498	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000549869	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000549869	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000549869	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000549869	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000442939	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000442939	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000442939	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000442939	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000457879	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000457879	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000457879	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000457879	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000438861	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000438861	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000438861	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000438861	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000547271	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000547271	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000547271	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000547271	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000453975	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000453975	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000453975	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000453975	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000547522	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000547522	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000547522	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000547522	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000383605	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000383605	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000383605	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000383605	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000383619	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000383619	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000383619	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000383619	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000549224	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000549224	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000549224	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000549224	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000376822	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000376822	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000376822	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000376822	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000456012	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000456012	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000456012	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000456012	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000550728	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000550728	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000550728	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000550728	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000450342	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000450342	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000450342	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000450342	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000454091	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000454091	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000454091	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000454091	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000488889	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000488889	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000488889	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000488889	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000552493	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000552493	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000552493	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000552493	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000414592	ENST00000216281	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-3CDS	ENST00000414592	ENST00000334701	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000414592	ENST00000441629	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-
intron-intron	ENST00000414592	ENST00000558600	HLA-A	chr6	29912028	+	HSP90AA1	chr14	102552707	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for HLA-A-HSP90AA1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HLA-A-HSP90AA1

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HLA-A P04439	HSP90AA1 P07900
FUNCTION: Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:2456340, PubMed:2784196, PubMed:1402688, PubMed:7504010, PubMed:9862734, PubMed:10449296, PubMed:12138174, PubMed:12393434, PubMed:15893615, PubMed:17189421, PubMed:19543285, PubMed:21498667, PubMed:24192765, PubMed:7694806, PubMed:24395804, PubMed:28250417). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:25880248, PubMed:7506728, PubMed:7679507). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:12796775, PubMed:18275829, PubMed:19542454, PubMed:28250417). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme (PubMed:17189421, PubMed:20364150, PubMed:17079320, PubMed:26929325, PubMed:27049119). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:7504010, PubMed:9862734). {ECO:0000269\|PubMed:10449296, ECO:0000269\|PubMed:12138174, ECO:0000269\|PubMed:12393434, ECO:0000269\|PubMed:12796775, ECO:0000269\|PubMed:1402688, ECO:0000269\|PubMed:15893615, ECO:0000269\|PubMed:17079320, ECO:0000269\|PubMed:17189421, ECO:0000269\|PubMed:18275829, ECO:0000269\|PubMed:19542454, ECO:0000269\|PubMed:19543285, ECO:0000269\|PubMed:20364150, ECO:0000269\|PubMed:21498667, ECO:0000269\|PubMed:24192765, ECO:0000269\|PubMed:24395804, ECO:0000269\|PubMed:2456340, ECO:0000269\|PubMed:25880248, ECO:0000269\|PubMed:26929325, ECO:0000269\|PubMed:27049119, ECO:0000269\|PubMed:2784196, ECO:0000269\|PubMed:28250417, ECO:0000269\|PubMed:7504010, ECO:0000269\|PubMed:7506728, ECO:0000269\|PubMed:7679507, ECO:0000269\|PubMed:7694806, ECO:0000269\|PubMed:9862734}.; FUNCTION: Allele A01:01: Presents a restricted peptide repertoire including viral epitopes derived from IAV NP/nucleoprotein (CTELKLSDY), IAV PB1/polymerase basic protein 1 (VSDGGPNLY), HAdV-11 capsid L3/hexon protein (LTDLGQNLLY), SARS-CoV-2 3a/ORF3a (FTSDYYQLY) as well as tumor peptide antigens including MAGE1 (EADPTGHSY), MAGEA3 (EVDPIGHLY) and WT1 (TSEKRPFMCAY), all having in common a canonical motif with a negatively charged Asp or Glu residue at position 3 and a Tyr anchor residue at the C-terminus (PubMed:1402688, PubMed:7504010, PubMed:17189421, PubMed:20364150, PubMed:25880248, PubMed:30530481, PubMed:19177349, PubMed:24395804, PubMed:26758806, PubMed:32887977). A number of HLA-A01:01-restricted peptides carry a post-translational modification with oxidation and N-terminal acetylation being the most frequent (PubMed:25880248). Fails to present highly immunogenic peptides from the EBV latent antigens (PubMed:18779413). {ECO:0000269\|PubMed:1402688, ECO:0000269\|PubMed:17189421, ECO:0000269\|PubMed:18779413, ECO:0000269\|PubMed:19177349, ECO:0000269\|PubMed:20364150, ECO:0000269\|PubMed:24395804, ECO:0000269\|PubMed:25880248, ECO:0000269\|PubMed:26758806, ECO:0000269\|PubMed:30530481, ECO:0000269\|PubMed:7504010}.; FUNCTION: Allele A02:01: A major allele in human populations, presents immunodominant viral epitopes derived from IAV M/matrix protein 1 (GILGFVFTL), HIV-1 env (TLTSCNTSV), HIV-1 gag-pol (ILKEPVHGV), HTLV-1 Tax (LLFGYPVYV), HBV C/core antigen (FLPSDFFPS), HCMV UL83/pp65 (NLVPMVATV) as well as tumor peptide antigens including MAGEA4 (GVYDGREHTV), WT1 (RMFPNAPYL) and CTAG1A/NY-ESO-1 (SLLMWITQC), all having in common hydrophobic amino acids at position 2 and at the C-terminal anchors. {ECO:0000269\|PubMed:11502003, ECO:0000269\|PubMed:12138174, ECO:0000269\|PubMed:12796775, ECO:0000269\|PubMed:17079320, ECO:0000269\|PubMed:18275829, ECO:0000269\|PubMed:19542454, ECO:0000269\|PubMed:20619457, ECO:0000269\|PubMed:22245737, ECO:0000269\|PubMed:26929325, ECO:0000269\|PubMed:2784196, ECO:0000269\|PubMed:28250417, ECO:0000269\|PubMed:7694806, ECO:0000269\|PubMed:7935798, ECO:0000269\|PubMed:8630735, ECO:0000269\|PubMed:8805302, ECO:0000269\|PubMed:8906788, ECO:0000269\|PubMed:9177355}.; FUNCTION: Allele A03:01: Presents viral epitopes derived from IAV NP (ILRGSVAHK), HIV-1 nef (QVPLRPMTYK), HIV-1 gag-pol (AIFQSSMTK), SARS-CoV-2 N/nucleoprotein (KTFPPTEPK) as well as tumor peptide antigens including PMEL (LIYRRRLMK), NODAL (HAYIQSLLK), TRP-2 (RMYNMVPFF), all having in common hydrophobic amino acids at position 2 and Lys or Arg anchor residues at the C-terminus (PubMed:7504010, PubMed:7679507, PubMed:9862734, PubMed:19543285, PubMed:21943705, PubMed:2456340, PubMed:32887977). May also display spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119). {ECO:0000269\|PubMed:19543285, ECO:0000269\|PubMed:21943705, ECO:0000269\|PubMed:2456340, ECO:0000269\|PubMed:27049119, ECO:0000269\|PubMed:7504010, ECO:0000269\|PubMed:7679507, ECO:0000269\|PubMed:9862734}.; FUNCTION: Allele A11:01: Presents several immunodominant epitopes derived from HIV-1 gag-pol and HHV-4 EBNA4, containing the peptide motif with Val, Ile, Thr, Leu, Tyr or Phe at position 2 and Lys anchor residue at the C-terminus. Important in the control of HIV-1, EBV and HBV infections (PubMed:10449296). Presents an immunodominant epitope derived from SARS-CoV-2 N/nucleoprotein (KTFPPTEPK) (PubMed:32887977). {ECO:0000269\|PubMed:10449296, ECO:0000269\|PubMed:32887977}.; FUNCTION: Allele A23:01: Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response. {ECO:0000269\|PubMed:17182537}.; FUNCTION: Allele A24:02: Presents viral epitopes derived from HIV-1 nef (RYPLTFGWCF), EBV lytic- and latent-cycle antigens BRLF1 (TYPVLEEMF), BMLF1 (DYNFVKQLF) and LMP2 (IYVLVMLVL), SARS-CoV nucleocapsid/N (QFKDNVILL), as well as tumor peptide antigens including PRAME (LYVDSLFFL), all sharing a common signature motif, namely an aromatic residue Tyr or Phe at position 2 and a nonhydrophobic anchor residue Phe, Leu or Iso at the C-terminus (PubMed:9047241, PubMed:12393434, PubMed:24192765, PubMed:20844028). Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response (PubMed:17182537, PubMed:18502829). {ECO:0000269\|PubMed:12393434, ECO:0000269\|PubMed:17182537, ECO:0000269\|PubMed:18502829, ECO:0000269\|PubMed:20844028, ECO:0000269\|PubMed:24192765, ECO:0000269\|PubMed:9047241}.; FUNCTION: Allele A26:01: Presents several epitopes derived from HIV-1 gag-pol (EVIPMFSAL, ETKLGKAGY) and env (LVSDGGPNLY), carrying as anchor residues preferentially Glu at position 1, Val or Thr at position 2 and Tyr at the C-terminus. {ECO:0000269\|PubMed:15893615}.; FUNCTION: Allele A29:02: Presents peptides having a common motif, namely a Glu residue at position 2 and Tyr or Leu anchor residues at the C-terminus. {ECO:0000269\|PubMed:8622959}.; FUNCTION: Allele A32:01: Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response. {ECO:0000269\|PubMed:17182537}.; FUNCTION: Allele A68:01: Presents viral epitopes derived from IAV NP (KTGGPIYKR) and HIV-1 tat (ITKGLGISYGR), having a common signature motif namely, Val or Thr at position 2 and positively charged residues Arg or Lys at the C-terminal anchor. {ECO:0000269\|PubMed:1448153, ECO:0000269\|PubMed:1448154, ECO:0000269\|PubMed:2784196}.; FUNCTION: Allele A74:01: Presents immunodominant HIV-1 epitopes derived from gag-pol (GQMVHQAISPR, QIYPGIKVR) and rev (RQIHSISER), carrying an aliphatic residue at position 2 and Arg anchor residue at the C-terminus. May contribute to viral load control in chronic HIV-1 infection. {ECO:0000269\|PubMed:21498667}.	FUNCTION: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155, PubMed:12526792). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues(PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochodria outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269\|PubMed:11274138, ECO:0000269\|PubMed:11276205, ECO:0000269\|PubMed:12526792, ECO:0000269\|PubMed:15577939, ECO:0000269\|PubMed:15937123, ECO:0000269\|PubMed:20628368, ECO:0000269\|PubMed:24613385, ECO:0000269\|PubMed:25609812, ECO:0000269\|PubMed:27353360, ECO:0000269\|PubMed:29127155, ECO:0000303\|PubMed:25973397, ECO:0000303\|PubMed:26991466, ECO:0000303\|PubMed:27295069}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for HLA-A-HSP90AA1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HLA-A-HSP90AA1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HLA-A-HSP90AA1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	HLA-A	P04439	DB11294	Coccidioides immitis spherule	Binder	Biotech	Approved
Hgene	HLA-A	P04439	DB11294	Coccidioides immitis spherule	Binder	Biotech	Approved
Hgene	HLA-A	P04439	DB11294	Coccidioides immitis spherule		Biotech	Approved
Hgene	HLA-A	P04439	DB11294	Coccidioides immitis spherule		Biotech	Approved
Tgene	HSP90AA1	P07900	DB00615	Rifabutin	Other/unknown	Small molecule	Approved\|Investigational
Tgene	HSP90AA1	P07900	DB00615	Rifabutin	Other/unknown	Small molecule	Approved\|Investigational
Tgene	HSP90AA1	P07900	DB00615	Rifabutin	Other/unknown	Small molecule	Approved\|Investigational
Tgene	HSP90AA1	P07900	DB00615	Rifabutin	Other/unknown	Small molecule	Approved\|Investigational
Tgene	HSP90AA1	P07900	DB00716	Nedocromil		Small molecule	Approved\|Investigational
Tgene	HSP90AA1	P07900	DB00716	Nedocromil		Small molecule	Approved\|Investigational
Tgene	HSP90AA1	P07900	DB00716	Nedocromil		Small molecule	Approved\|Investigational
Tgene	HSP90AA1	P07900	DB00716	Nedocromil		Small molecule	Approved\|Investigational
Tgene	HSP90AA1	P07900	DB09130	Copper		Small molecule	Approved\|Investigational
Tgene	HSP90AA1	P07900	DB09130	Copper		Small molecule	Approved\|Investigational
Tgene	HSP90AA1	P07900	DB09130	Copper		Small molecule	Approved\|Investigational
Tgene	HSP90AA1	P07900	DB09130	Copper		Small molecule	Approved\|Investigational

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Related Diseases for HLA-A-HSP90AA1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HLA-A	C0036341	Schizophrenia	4	PSYGENET
Hgene	HLA-A	C0019193	Hepatitis, Toxic	2	CTD_human
Hgene	HLA-A	C0860207	Drug-Induced Liver Disease	2	CTD_human
Hgene	HLA-A	C1262760	Hepatitis, Drug-Induced	2	CTD_human
Hgene	HLA-A	C3658290	Drug-Induced Acute Liver Injury	2	CTD_human
Hgene	HLA-A	C4277682	Chemical and Drug Induced Liver Injury	2	CTD_human
Hgene	HLA-A	C4279912	Chemically-Induced Liver Toxicity	2	CTD_human
Hgene	HLA-A	C0004352	Autistic Disorder	1	CTD_human
Hgene	HLA-A	C0014799	Erythroderma, Maculopapular	1	CTD_human
Hgene	HLA-A	C0017638	Glioma	1	CTD_human
Hgene	HLA-A	C0026764	Multiple Myeloma	1	CTD_human
Hgene	HLA-A	C0030437	Parakeratosis Variegata	1	CTD_human
Hgene	HLA-A	C0030491	Parapsoriasis	1	CTD_human
Hgene	HLA-A	C0036349	Paranoid Schizophrenia	1	PSYGENET
Hgene	HLA-A	C0040034	Thrombocytopenia	1	CTD_human
Hgene	HLA-A	C0162442	Parapsoriasis en Plaques	1	CTD_human
Hgene	HLA-A	C0259783	mixed gliomas	1	CTD_human
Hgene	HLA-A	C0555198	Malignant Glioma	1	CTD_human
Hgene	HLA-A	C1456784	Paranoia	1	PSYGENET
Hgene	HLA-A	C1853959	Birdshot chorioretinopathy	1	ORPHANET
Tgene	HSP90AA1	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	HSP90AA1	C0009178	Cocaine withdrawal	1	PSYGENET
Tgene	HSP90AA1	C0011616	Contact Dermatitis	1	CTD_human
Tgene	HSP90AA1	C0019693	HIV Infections	1	CTD_human
Tgene	HSP90AA1	C0027627	Neoplasm Metastasis	1	CTD_human
Tgene	HSP90AA1	C0041696	Unipolar Depression	1	PSYGENET
Tgene	HSP90AA1	C0162351	Contact hypersensitivity	1	CTD_human
Tgene	HSP90AA1	C0206180	Ki-1+ Anaplastic Large Cell Lymphoma	1	CTD_human
Tgene	HSP90AA1	C0525045	Mood Disorders	1	PSYGENET
Tgene	HSP90AA1	C0678222	Breast Carcinoma	1	CTD_human
Tgene	HSP90AA1	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	HSP90AA1	C1269683	Major Depressive Disorder	1	PSYGENET
Tgene	HSP90AA1	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	HSP90AA1	C4505456	HIV Coinfection	1	CTD_human
Tgene	HSP90AA1	C4704874	Mammary Carcinoma, Human	1	CTD_human