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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HLA-DPA1-TRIP12 (FusionGDB2 ID:36532)

Fusion Gene Summary for HLA-DPA1-TRIP12

Fusion gene summary

Fusion gene information	Fusion gene name: HLA-DPA1-TRIP12
	Fusion gene ID: 36532
		Hgene	Tgene
	Gene symbol	HLA-DPA1	TRIP12
	Gene ID	3113	9320
	Gene name	major histocompatibility complex, class II, DP alpha 1	thyroid hormone receptor interactor 12
	Synonyms	DP(W3)\|DP(W4)\|DPA1\|HLA-DP1A\|HLA-DPB1\|HLADP\|HLASB\|PLT1	MRD49\|TRIP-12\|TRIPC\|ULF
	Cytomap	6p21.32	2q36.3
	Type of gene	protein-coding	protein-coding
	Description	HLA class II histocompatibility antigen, DP alpha 1 chainHLA DPA1HLA-DPA101:03:01:NewHLA-DPA102:01:01:NEWHLA-SB alpha chainMHC class II DP alpha chainMHC class II DP3-alphaMHC class II HLA-DPA1 antigen	E3 ubiquitin-protein ligase TRIP12E3 ubiquitin-protein ligase for ArfHECT-type E3 ubiquitin transferase TRIP12TR-interacting protein 12probable E3 ubiquitin-protein ligase TRIP12thyroid receptor interacting protein 12
	Modification date	20200313	20200313
	UniProtAcc	P20036	.
	Ensembl transtripts involved in fusion gene	ENST00000419277, ENST00000428995, ENST00000463066, ENST00000443117, ENST00000551196, ENST00000480521, ENST00000415247, ENST00000484255, ENST00000454805, ENST00000549300, ENST00000475500, ENST00000374808, ENST00000552158, ENST00000488565, ENST00000383224, ENST00000551933, ENST00000474244, ENST00000422504, ENST00000550806, ENST00000494775, ENST00000515317, ENST00000550456, ENST00000502285,	ENST00000283943, ENST00000389045, ENST00000389044, ENST00000543084, ENST00000409677,
Fusion gene scores	* DoF score	7 X 8 X 3=168	16 X 13 X 7=1456
	# samples	10	18
	** MAII score	log2(10/168*10)=-0.748461233004036 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1456*10)=-3.01594154386902 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HLA-DPA1 [Title/Abstract] AND TRIP12 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HLA-DPA1(33032794)-TRIP12(230662547), # samples:1
Anticipated loss of major functional domain due to fusion event.	HLA-DPA1-TRIP12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HLA-DPA1	GO:0071346	cellular response to interferon-gamma	8568247
Tgene	TRIP12	GO:0000209	protein polyubiquitination	30982744
Tgene	TRIP12	GO:0006511	ubiquitin-dependent protein catabolic process	18627766\|20208519\|30982744

Fusion gene breakpoints across HLA-DPA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TRIP12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-ER-A1A1-06A	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-

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Fusion Gene ORF analysis for HLA-DPA1-TRIP12

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000419277	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000419277	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000419277	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000419277	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000419277	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
Frame-shift	ENST00000428995	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
Frame-shift	ENST00000428995	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
Frame-shift	ENST00000428995	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
5CDS-3UTR	ENST00000428995	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
5CDS-intron	ENST00000428995	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000463066	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000463066	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000463066	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000463066	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000463066	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000443117	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000443117	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000443117	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000443117	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000443117	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000551196	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000551196	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000551196	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000551196	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000551196	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000480521	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000480521	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000480521	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000480521	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000480521	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000415247	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000415247	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000415247	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000415247	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000415247	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000484255	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000484255	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000484255	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000484255	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000484255	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000454805	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000454805	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000454805	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000454805	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000454805	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000549300	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000549300	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000549300	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000549300	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000549300	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000475500	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000475500	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000475500	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000475500	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000475500	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000374808	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000374808	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000374808	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000374808	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000374808	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000552158	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000552158	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000552158	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000552158	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000552158	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000488565	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000488565	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000488565	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000488565	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000488565	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000383224	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000383224	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000383224	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000383224	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000383224	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000551933	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000551933	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000551933	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000551933	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000551933	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000474244	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000474244	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000474244	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000474244	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000474244	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000422504	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000422504	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000422504	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000422504	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000422504	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000550806	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000550806	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000550806	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000550806	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000550806	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000494775	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000494775	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000494775	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000494775	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000494775	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000515317	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000515317	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000515317	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000515317	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000515317	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000550456	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000550456	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000550456	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000550456	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000550456	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000502285	ENST00000283943	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000502285	ENST00000389045	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3CDS	ENST00000502285	ENST00000389044	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-3UTR	ENST00000502285	ENST00000543084	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-
intron-intron	ENST00000502285	ENST00000409677	HLA-DPA1	chr6	33032794	-	TRIP12	chr2	230662547	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for HLA-DPA1-TRIP12

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HLA-DPA1-TRIP12

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HLA-DPA1 P20036	.
FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for HLA-DPA1-TRIP12

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HLA-DPA1-TRIP12

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HLA-DPA1-TRIP12

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HLA-DPA1-TRIP12

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HLA-DPA1	C0162823	Dermatitis, Irritant	1	CTD_human
Hgene	HLA-DPA1	C0524909	Hepatitis B, Chronic	1	CTD_human
Hgene	HLA-DPA1	C3495801	Granulomatosis with polyangiitis	1	ORPHANET
Tgene	TRIP12	C4540324	MENTAL RETARDATION, AUTOSOMAL DOMINANT 49	2	GENOMICS_ENGLAND;UNIPROT
Tgene	TRIP12	C0018817	Atrial Septal Defects	1	GENOMICS_ENGLAND
Tgene	TRIP12	C1510586	Autism Spectrum Disorders	1	GENOMICS_ENGLAND
Tgene	TRIP12	C1535926	Neurodevelopmental Disorders	1	CTD_human
Tgene	TRIP12	C1862389	ATRIAL SEPTAL DEFECT 1	1	GENOMICS_ENGLAND