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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HLA-DQB1-SRSF3 (FusionGDB2 ID:36545)

Fusion Gene Summary for HLA-DQB1-SRSF3

Fusion gene summary

Fusion gene information	Fusion gene name: HLA-DQB1-SRSF3
	Fusion gene ID: 36545
		Hgene	Tgene
	Gene symbol	HLA-DQB1	SRSF3
	Gene ID	3120	6428
	Gene name	major histocompatibility complex, class II, DQ beta 2	serine and arginine rich splicing factor 3
	Synonyms	DQB2\|HLA-DQB1\|HLA-DXB	SFRS3\|SRp20
	Cytomap	6p21.32	6p21.31-p21.2
	Type of gene	protein-coding	protein-coding
	Description	HLA class II histocompatibility antigen, DQ beta 2 chainDV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB))HLA class II histocompatibility antigen, DX beta chainMHC class II antigen DQB2	serine/arginine-rich splicing factor 3epididymis secretory sperm binding proteinpre-mRNA splicing factor SRp20pre-mRNA-splicing factor SRP20splicing factor, arginine/serine-rich 3splicing factor, arginine/serine-rich, 20-kD
	Modification date	20200313	20200313
	UniProtAcc	P01920	.
	Ensembl transtripts involved in fusion gene	ENST00000399082, ENST00000399079, ENST00000374943, ENST00000434651, ENST00000399084, ENST00000460185, ENST00000383121, ENST00000548953, ENST00000434886, ENST00000430790, ENST00000416192, ENST00000399074, ENST00000422950, ENST00000486521, ENST00000424530, ENST00000433936, ENST00000399088, ENST00000399065, ENST00000413089, ENST00000476430, ENST00000383247, ENST00000399670, ENST00000551970, ENST00000415926, ENST00000428219, ENST00000419914, ENST00000421888, ENST00000424806, ENST00000547498, ENST00000493020, ENST00000414518, ENST00000549367, ENST00000548083,	ENST00000373715, ENST00000339436,
Fusion gene scores	* DoF score	5 X 5 X 2=50	11 X 11 X 3=363
	# samples	5	12
	** MAII score	log2(5/50*10)=0	log2(12/363*10)=-1.59693514238723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HLA-DQB1 [Title/Abstract] AND SRSF3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HLA-DQB1(32632574)-SRSF3(36568928), # samples:1
Anticipated loss of major functional domain due to fusion event.	HLA-DQB1-SRSF3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. HLA-DQB1-SRSF3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. HLA-DQB1-SRSF3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SRSF3	GO:0006406	mRNA export from nucleus	28984244
Tgene	SRSF3	GO:0048024	regulation of mRNA splicing, via spliceosome	26876937

Fusion gene breakpoints across HLA-DQB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SRSF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-BR-8060-11A	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+

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Fusion Gene ORF analysis for HLA-DQB1-SRSF3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000399082	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000399082	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
Frame-shift	ENST00000399079	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
5CDS-intron	ENST00000399079	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
Frame-shift	ENST00000374943	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
5CDS-intron	ENST00000374943	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
Frame-shift	ENST00000434651	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
5CDS-intron	ENST00000434651	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
Frame-shift	ENST00000399084	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
5CDS-intron	ENST00000399084	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000460185	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000460185	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000383121	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000383121	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000548953	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000548953	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000434886	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000434886	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000430790	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000430790	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000416192	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000416192	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000399074	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000399074	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000422950	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000422950	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000486521	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000486521	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000424530	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000424530	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000433936	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000433936	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000399088	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000399088	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000399065	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000399065	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000413089	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000413089	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000476430	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000476430	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000383247	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000383247	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000399670	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000399670	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000551970	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000551970	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000415926	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000415926	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000428219	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000428219	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000419914	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000419914	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000421888	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000421888	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000424806	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000424806	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000547498	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000547498	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000493020	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000493020	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000414518	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000414518	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000549367	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000549367	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-3CDS	ENST00000548083	ENST00000373715	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+
intron-intron	ENST00000548083	ENST00000339436	HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for HLA-DQB1-SRSF3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+	0.5516706	0.4483294
HLA-DQB1	chr6	32632574	-	SRSF3	chr6	36568928	+	0.5516706	0.4483294

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HLA-DQB1-SRSF3

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HLA-DQB1 P01920	.
FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for HLA-DQB1-SRSF3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HLA-DQB1-SRSF3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HLA-DQB1-SRSF3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	HLA-DQB1	P01920	DB00071	Insulin pork		Biotech	Approved
Hgene	HLA-DQB1	P01920	DB00071	Insulin pork		Biotech	Approved

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Related Diseases for HLA-DQB1-SRSF3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HLA-DQB1	C0027404	Narcolepsy	4	CTD_human;GENOMICS_ENGLAND;ORPHANET
Hgene	HLA-DQB1	C0030805	Bullous pemphigoid	2	ORPHANET
Hgene	HLA-DQB1	C0036341	Schizophrenia	2	PSYGENET
Hgene	HLA-DQB1	C0206085	Kleine-Levin Syndrome	2	GENOMICS_ENGLAND
Hgene	HLA-DQB1	C0751362	Narcolepsy-Cataplexy Syndrome	2	CTD_human;ORPHANET
Hgene	HLA-DQB1	C0002994	Angioedema	1	CTD_human
Hgene	HLA-DQB1	C0004096	Asthma	1	CTD_human
Hgene	HLA-DQB1	C0011609	Drug Eruptions	1	CTD_human
Hgene	HLA-DQB1	C0011854	Diabetes Mellitus, Insulin-Dependent	1	CTD_human
Hgene	HLA-DQB1	C0014848	Esophageal Achalasia	1	CTD_human;ORPHANET
Hgene	HLA-DQB1	C0017661	IGA Glomerulonephritis	1	CTD_human
Hgene	HLA-DQB1	C0019193	Hepatitis, Toxic	1	CTD_human
Hgene	HLA-DQB1	C0020517	Hypersensitivity	1	CTD_human
Hgene	HLA-DQB1	C0025164	Megaesophagus	1	CTD_human
Hgene	HLA-DQB1	C0026654	Moyamoya Disease	1	GENOMICS_ENGLAND
Hgene	HLA-DQB1	C0029295	Oropharyngeal Neoplasms	1	CTD_human
Hgene	HLA-DQB1	C0036421	Systemic Scleroderma	1	CTD_human
Hgene	HLA-DQB1	C0042109	Urticaria	1	CTD_human
Hgene	HLA-DQB1	C0205734	Diabetes, Autoimmune	1	CTD_human
Hgene	HLA-DQB1	C0342302	Brittle diabetes	1	CTD_human
Hgene	HLA-DQB1	C0406537	Morbilliform Drug Reaction	1	CTD_human
Hgene	HLA-DQB1	C0859976	Idiopathic achalasia of esophagus	1	ORPHANET
Hgene	HLA-DQB1	C0860207	Drug-Induced Liver Disease	1	CTD_human
Hgene	HLA-DQB1	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Hgene	HLA-DQB1	C1527304	Allergic Reaction	1	CTD_human
Hgene	HLA-DQB1	C2349952	Oropharyngeal Carcinoma	1	CTD_human
Hgene	HLA-DQB1	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Hgene	HLA-DQB1	C3837958	Diabetes Mellitus, Ketosis-Prone	1	CTD_human
Hgene	HLA-DQB1	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Hgene	HLA-DQB1	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human
Hgene	HLA-DQB1	C4554117	Diabetes Mellitus, Sudden-Onset	1	CTD_human
Hgene	HLA-DQB1	C4706583	Limbic encephalitis with leucine-rich glioma-inactivated 1 antibodies	1	ORPHANET
Tgene	SRSF3	C0005586	Bipolar Disorder	1	PSYGENET