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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:HLA-DQB2-NDUFS1 (FusionGDB2 ID:36546) |
Fusion Gene Summary for HLA-DQB2-NDUFS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HLA-DQB2-NDUFS1 | Fusion gene ID: 36546 | Hgene | Tgene | Gene symbol | HLA-DQB2 | NDUFS1 | Gene ID | 3120 | 4719 |
| Gene name | major histocompatibility complex, class II, DQ beta 2 | NADH:ubiquinone oxidoreductase core subunit S1 | |
| Synonyms | DQB2|HLA-DQB1|HLA-DXB | CI-75Kd|CI-75k|MC1DN5|PRO1304 | |
| Cytomap | 6p21.32 | 2q33.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | HLA class II histocompatibility antigen, DQ beta 2 chainDV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB))HLA class II histocompatibility antigen, DX beta chainMHC class II antigen DQB2 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialNADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)complex I 75kDa subunitcomplex I, mitochondrial respiratory chain, 75-kD subunitmitochondrial NADH-ubiquinone | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P05538 | P28331 | |
| Ensembl transtripts involved in fusion gene | ENST00000411527, ENST00000435145, ENST00000437316, ENST00000456529, ENST00000455520, ENST00000419685, ENST00000549642, ENST00000438757, ENST00000415137, ENST00000429783, ENST00000547938, ENST00000417780, ENST00000430849, ENST00000547371, ENST00000433801, ENST00000428972, ENST00000432486, ENST00000548910, ENST00000442043, ENST00000399658, ENST00000323109, ENST00000399661, ENST00000549204, ENST00000433114, ENST00000419519, ENST00000457432, ENST00000549667, ENST00000426733, ENST00000442806, ENST00000430668, ENST00000551426, | ENST00000233190, ENST00000423725, ENST00000457011, ENST00000440274, ENST00000455934, ENST00000449699, ENST00000432169, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 7 X 7 X 6=294 |
| # samples | 1 | 7 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: HLA-DQB2 [Title/Abstract] AND NDUFS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | HLA-DQB2(32724205)-NDUFS1(207003276), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NDUFS1 | GO:0008637 | apoptotic mitochondrial changes | 15186778 |
| Fusion gene breakpoints across HLA-DQB2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across NDUFS1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BE842948 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
Top |
Fusion Gene ORF analysis for HLA-DQB2-NDUFS1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000411527 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000411527 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000411527 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000411527 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000411527 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000411527 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000411527 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000435145 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000435145 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000435145 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000435145 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000435145 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000435145 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000435145 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000437316 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000437316 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000437316 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000437316 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000437316 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000437316 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000437316 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000456529 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000456529 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000456529 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000456529 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000456529 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000456529 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000456529 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000455520 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000455520 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000455520 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000455520 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000455520 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000455520 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000455520 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000419685 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000419685 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000419685 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000419685 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000419685 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000419685 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000419685 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549642 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549642 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549642 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549642 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549642 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549642 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549642 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000438757 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000438757 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000438757 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000438757 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000438757 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000438757 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000438757 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000415137 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000415137 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000415137 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000415137 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000415137 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000415137 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000415137 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000429783 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000429783 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000429783 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000429783 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000429783 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000429783 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000429783 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000547938 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000547938 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000547938 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000547938 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000547938 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000547938 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000547938 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000417780 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000417780 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000417780 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000417780 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000417780 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000417780 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000417780 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000430849 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000430849 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000430849 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000430849 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000430849 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000430849 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000430849 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000547371 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000547371 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000547371 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000547371 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000547371 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000547371 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000547371 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000433801 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000433801 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000433801 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000433801 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000433801 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000433801 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000433801 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000428972 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000428972 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000428972 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000428972 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000428972 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000428972 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000428972 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000432486 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000432486 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000432486 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000432486 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000432486 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000432486 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000432486 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000548910 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000548910 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000548910 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000548910 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000548910 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000548910 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000548910 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000442043 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000442043 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000442043 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000442043 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000442043 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000442043 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000442043 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000399658 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000399658 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000399658 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000399658 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000399658 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000399658 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000399658 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000323109 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000323109 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000323109 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000323109 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000323109 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000323109 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000323109 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000399661 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000399661 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000399661 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000399661 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000399661 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000399661 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000399661 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549204 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549204 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549204 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549204 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549204 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549204 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549204 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000433114 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000433114 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000433114 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000433114 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000433114 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000433114 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000433114 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000419519 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000419519 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000419519 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000419519 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000419519 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000419519 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000419519 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000457432 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000457432 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000457432 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000457432 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000457432 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000457432 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000457432 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549667 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549667 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549667 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549667 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549667 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549667 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000549667 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000426733 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000426733 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000426733 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000426733 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000426733 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000426733 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000426733 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000442806 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000442806 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000442806 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000442806 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000442806 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000442806 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000442806 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000430668 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000430668 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000430668 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000430668 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000430668 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000430668 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000430668 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000551426 | ENST00000233190 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000551426 | ENST00000423725 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000551426 | ENST00000457011 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000551426 | ENST00000440274 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000551426 | ENST00000455934 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000551426 | ENST00000449699 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| intron-3CDS | ENST00000551426 | ENST00000432169 | HLA-DQB2 | chr6 | 32724205 | + | NDUFS1 | chr2 | 207003276 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for HLA-DQB2-NDUFS1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for HLA-DQB2-NDUFS1 |
| Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HLA-DQB2 | NDUFS1 |
| FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. {ECO:0000269|PubMed:22407913}. | FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:30879903, PubMed:31557978). Essential for catalysing the entry and efficient transfer of electrons within complex I (PubMed:31557978). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (PubMed:30879903, PubMed:31557978). {ECO:0000269|PubMed:30879903, ECO:0000269|PubMed:31557978}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for HLA-DQB2-NDUFS1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for HLA-DQB2-NDUFS1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for HLA-DQB2-NDUFS1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | NDUFS1 | P28331 | DB00157 | NADH | Small molecule | Approved|Nutraceutical |
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Related Diseases for HLA-DQB2-NDUFS1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NDUFS1 | C0023264 | Leigh Disease | 12 | CLINGEN;GENOMICS_ENGLAND |
| Tgene | NDUFS1 | C1838951 | LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY | 12 | CLINGEN |
| Tgene | NDUFS1 | C1850597 | Leigh Syndrome Due To Mitochondrial Complex II Deficiency | 12 | CLINGEN |
| Tgene | NDUFS1 | C1850598 | Leigh Syndrome due to Mitochondrial Complex III Deficiency | 12 | CLINGEN |
| Tgene | NDUFS1 | C1850599 | Leigh Syndrome due to Mitochondrial Complex IV Deficiency | 12 | CLINGEN |
| Tgene | NDUFS1 | C1850600 | Leigh Syndrome due to Mitochondrial Complex V Deficiency | 12 | CLINGEN |
| Tgene | NDUFS1 | C2931891 | Necrotizing encephalopathy, infantile subacute, of Leigh | 12 | CLINGEN |
| Tgene | NDUFS1 | C1838979 | MITOCHONDRIAL COMPLEX I DEFICIENCY | 5 | GENOMICS_ENGLAND;ORPHANET |
| Tgene | NDUFS1 | C1656427 | Early onset schizophrenia | 2 | PSYGENET |
| Tgene | NDUFS1 | C0007194 | Hypertrophic Cardiomyopathy | 1 | CTD_human |
| Tgene | NDUFS1 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
| Tgene | NDUFS1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | NDUFS1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | NDUFS1 | C0235874 | Disease Exacerbation | 1 | CTD_human |
| Tgene | NDUFS1 | C0751651 | Mitochondrial Diseases | 1 | GENOMICS_ENGLAND |
| Tgene | NDUFS1 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
| Tgene | NDUFS1 | C4551472 | Hypertrophic obstructive cardiomyopathy | 1 | CTD_human |
| Tgene | NDUFS1 | C4748754 | MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 5 | 1 | GENOMICS_ENGLAND;UNIPROT |
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