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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HLA-DRB1-FGR (FusionGDB2 ID:36555)

Fusion Gene Summary for HLA-DRB1-FGR

check button Fusion gene summary
Fusion gene informationFusion gene name: HLA-DRB1-FGR
Fusion gene ID: 36555
HgeneTgene
Gene symbol

HLA-DRB1

FGR

Gene ID

3123

2268

Gene namemajor histocompatibility complex, class II, DR beta 1FGR proto-oncogene, Src family tyrosine kinase
SynonymsDRB1|HLA-DR1B|HLA-DRB|SS1SRC2|c-fgr|c-src2|p55-Fgr|p55c-fgr|p58-Fgr|p58c-fgr
Cytomap

6p21.32

1p35.3

Type of geneprotein-codingprotein-coding
Descriptionmajor histocompatibility complex, class II, DR beta 1 precursorHLA class II histocompatibility antigen, DR-1 beta chainMHC class II HLA-DR beta 1 chainhuman leucocyte antigen DRB1lymphocyte antigen DRB1tyrosine-protein kinase FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homologc-fgr protooncogenec-src-2 proto-oncogenefeline Gardner-Rasheed sarcoma viral oncogene homologp55-c-fgr proteinproto-oncogene c-Fgrproto-oncogene tyrosine-prote
Modification date2020032720200329
UniProtAcc.

P09769

Ensembl transtripts involved in fusion geneENST00000360004, ENST00000399450, 
ENST00000444645, ENST00000460546, 
ENST00000328980, ENST00000437784, 
ENST00000419393, ENST00000553034, 
ENST00000374005, ENST00000399173, 
ENST00000545953, ENST00000374004, 
ENST00000468038, 
Fusion gene scores* DoF score4 X 5 X 1=206 X 7 X 6=252
# samples 510
** MAII scorelog2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/252*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HLA-DRB1 [Title/Abstract] AND FGR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHLA-DRB1(32552203)-FGR(27942120), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFGR

GO:0018108

peptidyl-tyrosine phosphorylation

7519620|8327512

TgeneFGR

GO:0046777

protein autophosphorylation

2181286|8327512


check buttonFusion gene breakpoints across HLA-DRB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FGR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF849952HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
ChiTaRS5.0N/ABF849961HLA-DRB1chr6

32552203

-FGRchr1

27942120

+


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Fusion Gene ORF analysis for HLA-DRB1-FGR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000360004ENST00000374005HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000360004ENST00000399173HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000360004ENST00000545953HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000360004ENST00000374004HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-intronENST00000360004ENST00000468038HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000399450ENST00000374005HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000399450ENST00000399173HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000399450ENST00000545953HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000399450ENST00000374004HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-intronENST00000399450ENST00000468038HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000444645ENST00000374005HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000444645ENST00000399173HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000444645ENST00000545953HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000444645ENST00000374004HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-intronENST00000444645ENST00000468038HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000460546ENST00000374005HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000460546ENST00000399173HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000460546ENST00000545953HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000460546ENST00000374004HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-intronENST00000460546ENST00000468038HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000328980ENST00000374005HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000328980ENST00000399173HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000328980ENST00000545953HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000328980ENST00000374004HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-intronENST00000328980ENST00000468038HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000437784ENST00000374005HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000437784ENST00000399173HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000437784ENST00000545953HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000437784ENST00000374004HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-intronENST00000437784ENST00000468038HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000419393ENST00000374005HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000419393ENST00000399173HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000419393ENST00000545953HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000419393ENST00000374004HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-intronENST00000419393ENST00000468038HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000553034ENST00000374005HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000553034ENST00000399173HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000553034ENST00000545953HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-3CDSENST00000553034ENST00000374004HLA-DRB1chr6

32552203

-FGRchr1

27942120

+
intron-intronENST00000553034ENST00000468038HLA-DRB1chr6

32552203

-FGRchr1

27942120

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for HLA-DRB1-FGR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HLA-DRB1-FGR


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FGR

P09769

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for HLA-DRB1-FGR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HLA-DRB1-FGR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HLA-DRB1-FGR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFGRP09769DB01254DasatinibSmall moleculeApproved|Investigational
TgeneFGRP09769DB01254DasatinibSmall moleculeApproved|Investigational
TgeneFGRP09769DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneFGRP09769DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneFGRP09769DB15035ZanubrutinibInhibitorSmall moleculeApproved|Investigational
TgeneFGRP09769DB15035ZanubrutinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for HLA-DRB1-FGR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHLA-DRB1C0024141Lupus Erythematosus, Systemic8CTD_human;ORPHANET
HgeneHLA-DRB1C0003873Rheumatoid Arthritis3CTD_human
HgeneHLA-DRB1C0027404Narcolepsy3CTD_human;ORPHANET
HgeneHLA-DRB1C0751362Narcolepsy-Cataplexy Syndrome3CTD_human;ORPHANET
HgeneHLA-DRB1C0005138Berylliosis2CTD_human
HgeneHLA-DRB1C0027726Nephrotic Syndrome2CTD_human
HgeneHLA-DRB1C0030805Bullous pemphigoid2ORPHANET
HgeneHLA-DRB1C0033687Proteinuria2CTD_human
HgeneHLA-DRB1C0036202Sarcoidosis2CTD_human;ORPHANET
HgeneHLA-DRB1C2350873Beryllium Disease2CTD_human
HgeneHLA-DRB1C0002994Angioedema1CTD_human
HgeneHLA-DRB1C0004096Asthma1CTD_human
HgeneHLA-DRB1C0004352Autistic Disorder1CTD_human
HgeneHLA-DRB1C0005586Bipolar Disorder1PSYGENET
HgeneHLA-DRB1C0009324Ulcerative Colitis1CTD_human
HgeneHLA-DRB1C0010346Crohn Disease1CTD_human;GENOMICS_ENGLAND
HgeneHLA-DRB1C0011854Diabetes Mellitus, Insulin-Dependent1CTD_human
HgeneHLA-DRB1C0013182Drug Allergy1CTD_human
HgeneHLA-DRB1C0017665Membranous glomerulonephritis1CTD_human
HgeneHLA-DRB1C0019193Hepatitis, Toxic1CTD_human
HgeneHLA-DRB1C0020517Hypersensitivity1CTD_human
HgeneHLA-DRB1C0023290Leishmaniasis, Visceral1CTD_human
HgeneHLA-DRB1C0024301Lymphoma, Follicular1ORPHANET
HgeneHLA-DRB1C0024302Reticulosarcoma1CTD_human
HgeneHLA-DRB1C0024304Lymphoma, Mixed-Cell1CTD_human
HgeneHLA-DRB1C0024305Lymphoma, Non-Hodgkin1CTD_human
HgeneHLA-DRB1C0024306Lymphoma, Undifferentiated1CTD_human
HgeneHLA-DRB1C0026654Moyamoya Disease1GENOMICS_ENGLAND
HgeneHLA-DRB1C0026769Multiple Sclerosis1CTD_human
HgeneHLA-DRB1C0029295Oropharyngeal Neoplasms1CTD_human
HgeneHLA-DRB1C0030305Pancreatitis1CTD_human
HgeneHLA-DRB1C0036341Schizophrenia1CTD_human
HgeneHLA-DRB1C0041466Typhoid Fever1CTD_human
HgeneHLA-DRB1C0042109Urticaria1CTD_human
HgeneHLA-DRB1C0079740High Grade Lymphoma (neoplasm)1CTD_human
HgeneHLA-DRB1C0079741Lymphoma, Intermediate-Grade1CTD_human
HgeneHLA-DRB1C0079747Low Grade Lymphoma (neoplasm)1CTD_human
HgeneHLA-DRB1C0079757Diffuse Mixed-Cell Lymphoma1CTD_human
HgeneHLA-DRB1C0079770Lymphoma, Small Noncleaved-Cell1CTD_human
HgeneHLA-DRB1C0085179Eosinophilia-Myalgia Syndrome1CTD_human
HgeneHLA-DRB1C0086445Idiopathic Membranous Glomerulonephritis1CTD_human
HgeneHLA-DRB1C0087031Juvenile-Onset Still Disease1ORPHANET
HgeneHLA-DRB1C0156147Crohn's disease of large bowel1CTD_human
HgeneHLA-DRB1C0205734Diabetes, Autoimmune1CTD_human
HgeneHLA-DRB1C0242380Libman-Sacks Disease1CTD_human
HgeneHLA-DRB1C0267380Crohn's disease of the ileum1CTD_human
HgeneHLA-DRB1C0342302Brittle diabetes1CTD_human
HgeneHLA-DRB1C0678202Regional enteritis1CTD_human
HgeneHLA-DRB1C0751324Multiple Sclerosis, Acute Fulminating1CTD_human
HgeneHLA-DRB1C0751622Eosinophilia-Myalgia Syndrome, L-Tryptophan-Related1CTD_human
HgeneHLA-DRB1C0860207Drug-Induced Liver Disease1CTD_human
HgeneHLA-DRB1C0949272IIeocolitis1CTD_human
HgeneHLA-DRB1C1262760Hepatitis, Drug-Induced1CTD_human
HgeneHLA-DRB1C1384600Systemic onset juvenile chronic arthritis1ORPHANET
HgeneHLA-DRB1C1527304Allergic Reaction1CTD_human
HgeneHLA-DRB1C1704378Heymann Nephritis1CTD_human
HgeneHLA-DRB1C2349952Oropharyngeal Carcinoma1CTD_human
HgeneHLA-DRB1C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneHLA-DRB1C3714542Lymphoma, Diffuse1CTD_human
HgeneHLA-DRB1C3837958Diabetes Mellitus, Ketosis-Prone1CTD_human
HgeneHLA-DRB1C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneHLA-DRB1C4279912Chemically-Induced Liver Toxicity1CTD_human
HgeneHLA-DRB1C4554117Diabetes Mellitus, Sudden-Onset1CTD_human
HgeneHLA-DRB1C4706583Limbic encephalitis with leucine-rich glioma-inactivated 1 antibodies1ORPHANET
HgeneHLA-DRB1C4721532Lymphoma, Non-Hodgkin, Familial1CTD_human
TgeneFGRC0023893Liver Cirrhosis, Experimental1CTD_human