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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:HMGB1-KANSL2 (FusionGDB2 ID:36716) |
Fusion Gene Summary for HMGB1-KANSL2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: HMGB1-KANSL2 | Fusion gene ID: 36716 | Hgene | Tgene | Gene symbol | HMGB1 | KANSL2 | Gene ID | 3146 | 54934 |
Gene name | high mobility group box 1 | KAT8 regulatory NSL complex subunit 2 | |
Synonyms | HMG-1|HMG1|HMG3|SBP-1 | C12orf41|NSL2 | |
Cytomap | 13q12.3 | 12q13.11 | |
Type of gene | protein-coding | protein-coding | |
Description | high mobility group protein B1AmphoterinSulfoglucuronyl carbohydrate binding proteinhigh-mobility group (nonhistone chromosomal) protein 1 | KAT8 regulatory NSL complex subunit 2NSL complex protein NSL2non-specific lethal 2 homolog | |
Modification date | 20200329 | 20200313 | |
UniProtAcc | P09429 | Q9H9L4 | |
Ensembl transtripts involved in fusion gene | ENST00000405805, ENST00000339872, ENST00000341423, ENST00000399489, ENST00000399494, ENST00000326004, ENST00000468384, | ENST00000550347, ENST00000420613, ENST00000548701, ENST00000553086, ENST00000357861, | |
Fusion gene scores | * DoF score | 11 X 14 X 4=616 | 5 X 3 X 4=60 |
# samples | 14 | 5 | |
** MAII score | log2(14/616*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HMGB1 [Title/Abstract] AND KANSL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | HMGB1(31035403)-KANSL2(49047958), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | HMGB1 | GO:0002218 | activation of innate immune response | 24971542 |
Hgene | HMGB1 | GO:0002643 | regulation of tolerance induction | 18631454 |
Hgene | HMGB1 | GO:0006357 | regulation of transcription by RNA polymerase II | 11748232 |
Hgene | HMGB1 | GO:0006954 | inflammatory response | 23146691 |
Hgene | HMGB1 | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 22370717 |
Hgene | HMGB1 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly | 8006019 |
Hgene | HMGB1 | GO:0032072 | regulation of restriction endodeoxyribonuclease activity | 17803946 |
Hgene | HMGB1 | GO:0032425 | positive regulation of mismatch repair | 15014079 |
Hgene | HMGB1 | GO:0032689 | negative regulation of interferon-gamma production | 22473704 |
Hgene | HMGB1 | GO:0032733 | positive regulation of interleukin-10 production | 22473704 |
Hgene | HMGB1 | GO:0032755 | positive regulation of interleukin-6 production | 26961863 |
Hgene | HMGB1 | GO:0032757 | positive regulation of interleukin-8 production | 26961863 |
Hgene | HMGB1 | GO:0033151 | V(D)J recombination | 9166431 |
Hgene | HMGB1 | GO:0035711 | T-helper 1 cell activation | 22473704 |
Hgene | HMGB1 | GO:0043065 | positive regulation of apoptotic process | 19800306 |
Hgene | HMGB1 | GO:0043277 | apoptotic cell clearance | 18768881 |
Hgene | HMGB1 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 19800306 |
Hgene | HMGB1 | GO:0043371 | negative regulation of CD4-positive, alpha-beta T cell differentiation | 22473704 |
Hgene | HMGB1 | GO:0043388 | positive regulation of DNA binding | 11748232|19223331 |
Hgene | HMGB1 | GO:0043410 | positive regulation of MAPK cascade | 12765338 |
Hgene | HMGB1 | GO:0043537 | negative regulation of blood vessel endothelial cell migration | 23148224 |
Hgene | HMGB1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19223331 |
Hgene | HMGB1 | GO:0046330 | positive regulation of JNK cascade | 12765338 |
Hgene | HMGB1 | GO:0050716 | positive regulation of interleukin-1 secretion | 12765338 |
Hgene | HMGB1 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22370717 |
Hgene | HMGB1 | GO:0090026 | positive regulation of monocyte chemotaxis | 22370717 |
Hgene | HMGB1 | GO:0097350 | neutrophil clearance | 18768881 |
Hgene | HMGB1 | GO:1990774 | tumor necrosis factor secretion | 12765338 |
Hgene | HMGB1 | GO:2000343 | positive regulation of chemokine (C-X-C motif) ligand 2 production | 26961863 |
Hgene | HMGB1 | GO:2000426 | negative regulation of apoptotic cell clearance | 20826760 |
Hgene | HMGB1 | GO:2000778 | positive regulation of interleukin-6 secretion | 12765338 |
Tgene | KANSL2 | GO:0043981 | histone H4-K5 acetylation | 20018852 |
Tgene | KANSL2 | GO:0043982 | histone H4-K8 acetylation | 20018852 |
Tgene | KANSL2 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
Fusion gene breakpoints across HMGB1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across KANSL2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LGG | TCGA-E1-A7YQ | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
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Fusion Gene ORF analysis for HMGB1-KANSL2 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000405805 | ENST00000550347 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-3CDS | ENST00000405805 | ENST00000420613 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-5UTR | ENST00000405805 | ENST00000548701 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-5UTR | ENST00000405805 | ENST00000553086 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-intron | ENST00000405805 | ENST00000357861 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-3CDS | ENST00000339872 | ENST00000550347 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-3CDS | ENST00000339872 | ENST00000420613 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-5UTR | ENST00000339872 | ENST00000548701 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-5UTR | ENST00000339872 | ENST00000553086 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-intron | ENST00000339872 | ENST00000357861 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-3CDS | ENST00000341423 | ENST00000550347 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-3CDS | ENST00000341423 | ENST00000420613 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-5UTR | ENST00000341423 | ENST00000548701 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-5UTR | ENST00000341423 | ENST00000553086 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-intron | ENST00000341423 | ENST00000357861 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-3CDS | ENST00000399489 | ENST00000550347 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-3CDS | ENST00000399489 | ENST00000420613 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-5UTR | ENST00000399489 | ENST00000548701 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-5UTR | ENST00000399489 | ENST00000553086 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-intron | ENST00000399489 | ENST00000357861 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-3CDS | ENST00000399494 | ENST00000550347 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-3CDS | ENST00000399494 | ENST00000420613 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-5UTR | ENST00000399494 | ENST00000548701 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-5UTR | ENST00000399494 | ENST00000553086 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-intron | ENST00000399494 | ENST00000357861 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-3CDS | ENST00000326004 | ENST00000550347 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-3CDS | ENST00000326004 | ENST00000420613 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-5UTR | ENST00000326004 | ENST00000548701 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-5UTR | ENST00000326004 | ENST00000553086 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-intron | ENST00000326004 | ENST00000357861 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-3CDS | ENST00000468384 | ENST00000550347 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-3CDS | ENST00000468384 | ENST00000420613 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-5UTR | ENST00000468384 | ENST00000548701 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-5UTR | ENST00000468384 | ENST00000553086 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
intron-intron | ENST00000468384 | ENST00000357861 | HMGB1 | chr13 | 31035403 | - | KANSL2 | chr12 | 49047958 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for HMGB1-KANSL2 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for HMGB1-KANSL2 |
Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
HMGB1 | KANSL2 |
FUNCTION: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (Ref.71). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|Ref.71, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19446504, PubMed:19360789). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation. {ECO:0000269|Ref.71}. | FUNCTION: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. {ECO:0000269|PubMed:20018852}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for HMGB1-KANSL2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for HMGB1-KANSL2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for HMGB1-KANSL2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | HMGB1 | P09429 | DB00608 | Chloroquine | Inhibitor | Small molecule | Approved|Investigational|Vet_approved |
Hgene | HMGB1 | P09429 | DB00608 | Chloroquine | Inhibitor | Small molecule | Approved|Investigational|Vet_approved |
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Related Diseases for HMGB1-KANSL2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HMGB1 | C0021368 | Inflammation | 5 | CTD_human |
Hgene | HMGB1 | C0027540 | Necrosis | 2 | CTD_human |
Hgene | HMGB1 | C0034189 | Pyemia | 2 | CTD_human |
Hgene | HMGB1 | C0036690 | Septicemia | 2 | CTD_human |
Hgene | HMGB1 | C0243026 | Sepsis | 2 | CTD_human |
Hgene | HMGB1 | C1719672 | Severe Sepsis | 2 | CTD_human |
Hgene | HMGB1 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | HMGB1 | C0005398 | Cholestasis, Extrahepatic | 1 | CTD_human |
Hgene | HMGB1 | C0013221 | Drug toxicity | 1 | CTD_human |
Hgene | HMGB1 | C0015967 | Fever | 1 | CTD_human |
Hgene | HMGB1 | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
Hgene | HMGB1 | C0020429 | Hyperalgesia | 1 | CTD_human |
Hgene | HMGB1 | C0026766 | Multiple Organ Failure | 1 | CTD_human |
Hgene | HMGB1 | C0027051 | Myocardial Infarction | 1 | CTD_human |
Hgene | HMGB1 | C0027055 | Myocardial Reperfusion Injury | 1 | CTD_human |
Hgene | HMGB1 | C0027796 | Neuralgia | 1 | CTD_human |
Hgene | HMGB1 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
Hgene | HMGB1 | C0038870 | Neuralgia, Supraorbital | 1 | CTD_human |
Hgene | HMGB1 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
Hgene | HMGB1 | C0042656 | Neuralgia, Vidian | 1 | CTD_human |
Hgene | HMGB1 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | HMGB1 | C0234247 | Neuralgia, Atypical | 1 | CTD_human |
Hgene | HMGB1 | C0234249 | Neuralgia, Stump | 1 | CTD_human |
Hgene | HMGB1 | C0264939 | Systemic Vasculitis | 1 | CTD_human |
Hgene | HMGB1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Hgene | HMGB1 | C0282548 | Leukostasis | 1 | CTD_human |
Hgene | HMGB1 | C0423711 | Neuralgia, Perineal | 1 | CTD_human |
Hgene | HMGB1 | C0423712 | Neuralgia, Iliohypogastric Nerve | 1 | CTD_human |
Hgene | HMGB1 | C0458247 | Allodynia | 1 | CTD_human |
Hgene | HMGB1 | C0751211 | Hyperalgesia, Primary | 1 | CTD_human |
Hgene | HMGB1 | C0751212 | Hyperalgesia, Secondary | 1 | CTD_human |
Hgene | HMGB1 | C0751213 | Tactile Allodynia | 1 | CTD_human |
Hgene | HMGB1 | C0751214 | Hyperalgesia, Thermal | 1 | CTD_human |
Hgene | HMGB1 | C0751371 | Neuralgia, Ilioinguinal | 1 | CTD_human |
Hgene | HMGB1 | C0751372 | Nerve Pain | 1 | CTD_human |
Hgene | HMGB1 | C0751373 | Paroxysmal Nerve Pain | 1 | CTD_human |
Hgene | HMGB1 | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
Hgene | HMGB1 | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
Hgene | HMGB1 | C1850383 | Neuropathy, Painful | 1 | CTD_human |
Hgene | HMGB1 | C2936719 | Mechanical Allodynia | 1 | CTD_human |
Hgene | HMGB1 | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
Hgene | HMGB1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Hgene | HMGB1 | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
Hgene | HMGB1 | C4721507 | Alveolitis, Fibrosing | 1 | CTD_human |