Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HOOK1-RAB6A (FusionGDB2 ID:37218)

Fusion Gene Summary for HOOK1-RAB6A

Fusion gene summary

Fusion gene information	Fusion gene name: HOOK1-RAB6A
	Fusion gene ID: 37218
		Hgene	Tgene
	Gene symbol	HOOK1	RAB6A
	Gene ID	51361	5870
	Gene name	hook microtubule tethering protein 1	RAB6A, member RAS oncogene family
	Synonyms	HK1	RAB6
	Cytomap	1p32.1	11q13.4
	Type of gene	protein-coding	protein-coding
	Description	protein Hook homolog 1h-hook1hHK1hook homolog 1	ras-related protein Rab-6ARAB6, member RAS oncogene familyRab GTPase
	Modification date	20200313	20200313
	UniProtAcc	.	RGP1
	Ensembl transtripts involved in fusion gene	ENST00000371208, ENST00000465876, ENST00000395561,	ENST00000310653, ENST00000336083, ENST00000536566, ENST00000541588,
Fusion gene scores	* DoF score	4 X 7 X 4=112	20 X 15 X 10=3000
	# samples	7	29
	** MAII score	log2(7/112*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(29/3000*10)=-3.37083769536831 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HOOK1 [Title/Abstract] AND RAB6A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HOOK1(60280852)-RAB6A(73390765), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RAB6A	GO:0018125	peptidyl-cysteine methylation	11121396
Tgene	RAB6A	GO:0034067	protein localization to Golgi apparatus	12447383\|18243103

Fusion gene breakpoints across HOOK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAB6A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AR-A24Z-01A	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-
ChimerDB4	BRCA	TCGA-AR-A24Z	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-
ChimerDB4	BRCA	TCGA-AR-A24Z-01A	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-

Top

Fusion Gene ORF analysis for HOOK1-RAB6A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000371208	ENST00000310653	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-
In-frame	ENST00000371208	ENST00000336083	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-
In-frame	ENST00000371208	ENST00000536566	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-
In-frame	ENST00000371208	ENST00000541588	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-
3UTR-3CDS	ENST00000465876	ENST00000310653	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-
3UTR-3CDS	ENST00000465876	ENST00000336083	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-
3UTR-3CDS	ENST00000465876	ENST00000536566	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-
3UTR-3CDS	ENST00000465876	ENST00000541588	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-
intron-3CDS	ENST00000395561	ENST00000310653	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-
intron-3CDS	ENST00000395561	ENST00000336083	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-
intron-3CDS	ENST00000395561	ENST00000536566	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-
intron-3CDS	ENST00000395561	ENST00000541588	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000371208	HOOK1	chr1	60280852	+	ENST00000310653	RAB6A	chr11	73390765	-	2712	320	421	2	140
ENST00000371208	HOOK1	chr1	60280852	+	ENST00000336083	RAB6A	chr11	73390765	-	2454	320	421	2	140
ENST00000371208	HOOK1	chr1	60280852	+	ENST00000536566	RAB6A	chr11	73390765	-	951	320	421	2	140
ENST00000371208	HOOK1	chr1	60280852	+	ENST00000541588	RAB6A	chr11	73390765	-	456	320	421	2	140

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000371208	ENST00000310653	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-	0.6103833	0.38961676
ENST00000371208	ENST00000336083	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-	0.65277636	0.3472236
ENST00000371208	ENST00000536566	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-	0.33374786	0.66625214
ENST00000371208	ENST00000541588	HOOK1	chr1	60280852	+	RAB6A	chr11	73390765	-	0.13855033	0.86144966

Top

Fusion Genomic Features for HOOK1-RAB6A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for HOOK1-RAB6A

Go to
FGviewer for the breakpoints of chr1:60280852-chr11:73390765
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	RAB6A RGP1
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	1748

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000536566

156_158

132.0

176.0

Nucleotide binding

GTP

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000541588

126_129

61.0

105.0

Nucleotide binding

GTP

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000541588

156_158

61.0

105.0

Nucleotide binding

GTP

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000541588

68_72

61.0

105.0

Nucleotide binding

GTP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HOOK1

chr1:60280852

chr11:73390765

ENST00000371208

169_434

21.0

729.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

HOOK1

chr1:60280852

chr11:73390765

ENST00000371208

477_658

21.0

729.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

HOOK1

chr1:60280852

chr11:73390765

ENST00000371208

12_128

21.0

729.0

Domain

Calponin-homology (CH)

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000310653

42_50

165.0

209.0

Motif

Effector region

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000336083

42_50

165.0

209.0

Motif

Effector region

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000536566

42_50

132.0

176.0

Motif

Effector region

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000541588

42_50

61.0

105.0

Motif

Effector region

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000310653

126_129

165.0

209.0

Nucleotide binding

GTP

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000310653

156_158

165.0

209.0

Nucleotide binding

GTP

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000310653

20_28

165.0

209.0

Nucleotide binding

GTP

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000310653

68_72

165.0

209.0

Nucleotide binding

GTP

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000336083

126_129

165.0

209.0

Nucleotide binding

GTP

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000336083

156_158

165.0

209.0

Nucleotide binding

GTP

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000336083

20_28

165.0

209.0

Nucleotide binding

GTP

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000336083

68_72

165.0

209.0

Nucleotide binding

GTP

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000536566

126_129

132.0

176.0

Nucleotide binding

GTP

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000536566

20_28

132.0

176.0

Nucleotide binding

GTP

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000536566

68_72

132.0

176.0

Nucleotide binding

GTP

Tgene

RAB6A

chr1:60280852

chr11:73390765

ENST00000541588

20_28

61.0

105.0

Nucleotide binding

GTP

Top

Fusion Gene Sequence for HOOK1-RAB6A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000371208_ENST00000310653_TCGA-AR-A24Z-01A_HOOK1_chr1_60280852_+_RAB6A_chr11_73390765_length(transcript)=2712nt_BP=320nt
GCGGGGCTCAGGTGCCTGGCAGCGCGGCCGGGGCCCAGGAAGGGGAGGGGGCGAACGCTGGAGCGAGGCGGGGGCGGGTGAGGAGGGGGT
GACGCCGGACGCGTCGACAGCGCGAGGGTTCGCGCGTGAGCTGCGCGGGTCGGGCCTGGTACCGAGCTTTCCTGGGGGCTAGCAGGTCGT
GGACGCCGGCTCCTGGAGGAGAGCCGGTAGGAGGGAGTGTGAAGGTGTCCGCGGCGTCGTCGACGGCGGCGCCGGCCATGGAGGAGACGC
AGCCGCCGCCGCAGCCTAAGCTGCCCCTGTGCGACAGCCTCATGATCTGGCTCTTTCGACGTGTAGCAGCAGCTTTGCCGGGAATGGAAA
GCACACAGGACAGAAGCAGAGAAGATATGATTGACATAAAACTGGAAAAGCCTCAGGAGCAACCAGTCAGTGAAGGAGGCTGTTCCTGCT
AATCTCCCATGTCATCTTCAACCTTCTTCAGAAGCTCACTGCTTTGGCCCCCTTACTCTTTCATTGACTGCAGTGTGAATATTGGCTTGA
ACCTTTTCCCTTCAGTAATAACGTATTGCAATTCATCATTGCTGCCTGTCTCGTGGAGATGATCTATTAGCTTCACAAGCACAACAAAAG
TCAGTGTCTTCATTATTTATATTTTACAAAAAGCCAAAATATTTCAGCATATTCCAGTGATAACTTTAAAAATTAGATACATTTTCTTAA
CATTTTTTTCTTTTTTAATGTTATGATAATGTACTTCAAAATGATGGAAATCTCAACAGTATGAGTATGGCTTGGTTAACGAGCGGTATG
TTCACAGCCTACTTTATCTCTCCTTGCTTTTCTCACCTCTCACTTACCCCCATTCCCTATTACCCTATTCTTACCTAGCCTCCCCCGACT
TCCTCAAAACAAACAAGAGATGGCAAAGCAGCAGTTCTACCAAGCCCATTGGAATTATCCTTTAATTTTACAGATACCACTTGCTGTAGG
CTACGGACCAAGATGTCCAAAATTATTCTTGAGCACTGATATAAATTACGGTCTTCTTTGAGGTCAAAATTCAGCCATCATGGTAGGCAG
TGCTTGAATGAGAAAAGGCTCCTGGTGCATCTTCAAAATGAGTCCTAAAGAACATACTGAGTACTTAGAAGTAGAAGAACATAAGATGTA
TTTCTGACTAAAACAAATGGCTCTTTCACATGTGCTTTATTAGACTCTGGGAGAGAAAATTAACCAAGTGCTTCAGAACAGGTTTTTAGT
ATTTAATTCTTCACGGTAAGAAAATGAAGTTCTAATGAACTGTTTCTCCCAAGGTTTTAAAATTGTCAAGAGTTATTCTGTTTGTTTAAA
AAATAAGAAACCTCTTTAAGCAATAGATTTTGCTTGGGTTTTCTTTTTTAAAAACATAATACTGTGCAGGCAAGGCACTGTAAAAGTTTT
AATTCCTTCCAGAAGAACCAGTGGAAGAATTTAAATTTGGCGCTACGATCAAAACTACTGAATTAGTAGAAATAATGATGTCTAAAGCTT
ACCAACAAAAGAACCCTCAGCAGAATAACAAAAACTTTGCTCAGGACATTTGAGGTCAAATTGAAGACGGAAACCGGAAACCGTTTTCTT
GTAAGCCCCTAGAGGCAGATCAGGTAAAGCATACATAGTAGAGGGAAAGGAGAGAATGGAAATAAAACTCAATATTATGCAGATTTATGC
CTTATTTTTTAGCATTTTTTAAGGTTGGGTCTTTCAGGCTGGTTTTGGTTTGTATTAGATCTGTATAGTTTAATTAACTGGTGATTTAGT
TTTATATTTAAGCTACAATTAATCTTTTTTCTTTGGTGATATTTATTTCTTTGCCTTTTTTTTTTTTAACAACTTTCAATCTTCAGATGT
TTCGTTGAATCTATTTAGAGCTTCACCATGGCAATATGTATTTCCCTTAAAACACTGCAAACAAATATACTAGGAGTGTGCCCTTTTAAT
CTTTACTAGTTATTGTGAGATTGCTGTGTAAGCTAATAAACACATTTGTAAATACATTGTTTGCAGGACGAAAACTTCTGAGTTACAGCT
CAGGAAAAGCCTGCTGAATTTATGTTGTAAGCATTACTTAACACAGTATAAAGATGAAAAGACAACAAAAATATCTTCATACTTCCTCAT
CCCCTCATTGGAACAAAACCTTAAACTGGGAGAACCTTAGTCCCCTCTCTTTCCTCTTCCTCCTCCACTTCCCACTTATTGTCACCTTGT
AATATTCAGAGAGCACTTGGATTATGGATCTGAATAGAGAAATGCTTACAGATAATCATTAGCCCACATACCAGTAACTTATACTTAAAG
ATGGGATGGAGTTGTAAAGTGCTTTTATAATACAATATAATTGTTAAAGGCAAGGGTTGACTCTTTGTTTTATTTTGACATGGCATGTCC
TGAAATAAATATTGATTCAATATGGCAGATGGGTCATATTCTTTATTTGGAAGAAGTTGTGACTTCTGACATGGGTGTGATTGTCTTCCT
ACACTGTTGCATTTGATTCTTTTTATGTATTTTTAAGAAAGTAACCAGTTATACTGCTTTTAATATTGATTGGTCTTTTTATTTGGCTTG
GAGTTCTTCAAAGCATTGAAGTGTGTTCATAGTCCAGGTTTTTTTTTTAATAAACACAATTTTGCTGCCAAAAATATATAAATAAAACAC

>In-frame_ENST00000371208_ENST00000310653_TCGA-AR-A24Z-01A_HOOK1_chr1_60280852_+_RAB6A_chr11_73390765_length(amino acids)=140AA_start in transcript=421_stop in transcript=2
MLLRLFQFYVNHIFSASVLCAFHSRQSCCYTSKEPDHEAVAQGQLRLRRRLRLLHGRRRRRRRRGHLHTPSYRLSSRSRRPRPASPQESS

--------------------------------------------------------------
>In-frame_ENST00000371208_ENST00000336083_TCGA-AR-A24Z-01A_HOOK1_chr1_60280852_+_RAB6A_chr11_73390765_length(transcript)=2454nt_BP=320nt
GCGGGGCTCAGGTGCCTGGCAGCGCGGCCGGGGCCCAGGAAGGGGAGGGGGCGAACGCTGGAGCGAGGCGGGGGCGGGTGAGGAGGGGGT
GACGCCGGACGCGTCGACAGCGCGAGGGTTCGCGCGTGAGCTGCGCGGGTCGGGCCTGGTACCGAGCTTTCCTGGGGGCTAGCAGGTCGT
GGACGCCGGCTCCTGGAGGAGAGCCGGTAGGAGGGAGTGTGAAGGTGTCCGCGGCGTCGTCGACGGCGGCGCCGGCCATGGAGGAGACGC
AGCCGCCGCCGCAGCCTAAGCTGCCCCTGTGCGACAGCCTCATGATCTGGCTCTTTCGACGTGTAGCAGCAGCTTTGCCGGGAATGGAAA
GCACACAGGACAGAAGCAGAGAAGATATGATTGACATAAAACTGGAAAAGCCTCAGGAGCAACCAGTCAGTGAAGGAGGCTGTTCCTGCT
AATCTCCCATGTCATCTTCAACCTTCTTCAGAAGCTCACTGCTTTGGCCCCCTTACTCTTTCATTGACTGCAGTGTGAATATTGGCTTGA
ACCTTTTCCCTTCAGTAATAACGTATTGCAATTCATCATTGCTGCCTGTCTCGTGGAGATGATCTATTAGCTTCACAAGCACAACAAAAG
TCAGTGTCTTCATTATTTATATTTTACAAAAAGCCAAAATATTTCAGCATATTCCAGTGATAACTTTAAAAATTAGATACATTTTCTTAA
CATTTTTTTCTTTTTTAATGTTATGATAATGTACTTCAAAATGATGGAAATCTCAACAGTATGAGTATGGCTTGGTTAACGAGCGGTATG
TTCACAGCCTACTTTATCTCTCCTTGCTTTTCTCACCTCTCACTTACCCCCATTCCCTATTACCCTATTCTTACCTAGCCTCCCCCGACT
TCCTCAAAACAAACAAGAGATGGCAAAGCAGCAGTTCTACCAAGCCCATTGGAATTATCCTTTAATTTTACAGATACCACTTGCTGTAGG
CTACGGACCAAGATGTCCAAAATTATTCTTGAGCACTGATATAAATTACGGTCTTCTTTGAGGTCAAAATTCAGCCATCATGGTAGGCAG
TGCTTGAATGAGAAAAGGCTCCTGGTGCATCTTCAAAATGAGTCCTAAAGAACATACTGAGTACTTAGAAGTAGAAGAACATAAGATGTA
TTTCTGACTAAAACAAATGGCTCTTTCACATGTGCTTTATTAGACTCTGGGAGAGAAAATTAACCAAGTGCTTCAGAACAGGTTTTTAGT
ATTTAATTCTTCACGGTAAGAAAATGAAGTTCTAATGAACTGTTTCTCCCAAGGTTTTAAAATTGTCAAGAGTTATTCTGTTTGTTTAAA
AAATAAGAAACCTCTTTAAGCAATAGATTTTGCTTGGGTTTTCTTTTTTAAAAACATAATACTGTGCAGGCAAGGCACTGTAAAAGTTTT
AATTCCTTCCAGAAGAACCAGTGGAAGAATTTAAATTTGGCGCTACGATCAAAACTACTGAATTAGTAGAAATAATGATGTCTAAAGCTT
ACCAACAAAAGAACCCTCAGCAGAATAACAAAAACTTTGCTCAGGACATTTGAGGTCAAATTGAAGACGGAAACCGGAAACCGTTTTCTT
GTAAGCCCCTAGAGGCAGATCAGGTAAAGCATACATAGTAGAGGGAAAGGAGAGAATGGAAATAAAACTCAATATTATGCAGATTTATGC
CTTATTTTTTAGCATTTTTTAAGGTTGGGTCTTTCAGGCTGGTTTTGGTTTGTATTAGATCTGTATAGTTTAATTAACTGGTGATTTAGT
TTTATATTTAAGCTACAATTAATCTTTTTTCTTTGGTGATATTTATTTCTTTGCCTTTTTTTTTTTTAACAACTTTCAATCTTCAGATGT
TTCGTTGAATCTATTTAGAGCTTCACCATGGCAATATGTATTTCCCTTAAAACACTGCAAACAAATATACTAGGAGTGTGCCCTTTTAAT
CTTTACTAGTTATTGTGAGATTGCTGTGTAAGCTAATAAACACATTTGTAAATACATTGTTTGCAGGACGAAAACTTCTGAGTTACAGCT
CAGGAAAAGCCTGCTGAATTTATGTTGTAAGCATTACTTAACACAGTATAAAGATGAAAAGACAACAAAAATATCTTCATACTTCCTCAT
CCCCTCATTGGAACAAAACCTTAAACTGGGAGAACCTTAGTCCCCTCTCTTTCCTCTTCCTCCTCCACTTCCCACTTATTGTCACCTTGT
AATATTCAGAGAGCACTTGGATTATGGATCTGAATAGAGAAATGCTTACAGATAATCATTAGCCCACATACCAGTAACTTATACTTAAAG
ATGGGATGGAGTTGTAAAGTGCTTTTATAATACAATATAATTGTTAAAGGCAAGGGTTGACTCTTTGTTTTATTTTGACATGGCATGTCC

>In-frame_ENST00000371208_ENST00000336083_TCGA-AR-A24Z-01A_HOOK1_chr1_60280852_+_RAB6A_chr11_73390765_length(amino acids)=140AA_start in transcript=421_stop in transcript=2
MLLRLFQFYVNHIFSASVLCAFHSRQSCCYTSKEPDHEAVAQGQLRLRRRLRLLHGRRRRRRRRGHLHTPSYRLSSRSRRPRPASPQESS

--------------------------------------------------------------
>In-frame_ENST00000371208_ENST00000536566_TCGA-AR-A24Z-01A_HOOK1_chr1_60280852_+_RAB6A_chr11_73390765_length(transcript)=951nt_BP=320nt
GCGGGGCTCAGGTGCCTGGCAGCGCGGCCGGGGCCCAGGAAGGGGAGGGGGCGAACGCTGGAGCGAGGCGGGGGCGGGTGAGGAGGGGGT
GACGCCGGACGCGTCGACAGCGCGAGGGTTCGCGCGTGAGCTGCGCGGGTCGGGCCTGGTACCGAGCTTTCCTGGGGGCTAGCAGGTCGT
GGACGCCGGCTCCTGGAGGAGAGCCGGTAGGAGGGAGTGTGAAGGTGTCCGCGGCGTCGTCGACGGCGGCGCCGGCCATGGAGGAGACGC
AGCCGCCGCCGCAGCCTAAGCTGCCCCTGTGCGACAGCCTCATGATCTGGCTCTTTCGACGTGTAGCAGCAGCTTTGCCGGGAATGGAAA
GCACACAGGACAGAAGCAGAGAAGATATGATTGACATAAAACTGGAAAAGCCTCAGGAGCAACCAGTCAGTGAAGGAGGCTGTTCCTGCT
AATCTCCCATGTCATCTTCAACCTTCTTCAGAAGCTCACTGCTTTGGCCCCCTTACTCTTTCATTGACTGCAGTGTGAATATTGGCTTGA
ACCTTTTCCCTTCAGTAATAACGTATTGCAATTCATCATTGCTGCCTGTCTCGTGGAGATGATCTATTAGCTTCACAAGCACAACAAAAG
TCAGTGTCTTCATTATTTATATTTTACAAAAAGCCAAAATATTTCAGCATATTCCAGTGATAACTTTAAAAATTAGATACATTTTCTTAA
CATTTTTTTCTTTTTTAATGTTATGATAATGTACTTCAAAATGATGGAAATCTCAACAGTATGAGTATGGCTTGGTTAACGAGCGGTATG
TTCACAGCCTACTTTATCTCTCCTTGCTTTTCTCACCTCTCACTTACCCCCATTCCCTATTACCCTATTCTTACCTAGCCTCCCCCGACT

>In-frame_ENST00000371208_ENST00000536566_TCGA-AR-A24Z-01A_HOOK1_chr1_60280852_+_RAB6A_chr11_73390765_length(amino acids)=140AA_start in transcript=421_stop in transcript=2
MLLRLFQFYVNHIFSASVLCAFHSRQSCCYTSKEPDHEAVAQGQLRLRRRLRLLHGRRRRRRRRGHLHTPSYRLSSRSRRPRPASPQESS

--------------------------------------------------------------
>In-frame_ENST00000371208_ENST00000541588_TCGA-AR-A24Z-01A_HOOK1_chr1_60280852_+_RAB6A_chr11_73390765_length(transcript)=456nt_BP=320nt
GCGGGGCTCAGGTGCCTGGCAGCGCGGCCGGGGCCCAGGAAGGGGAGGGGGCGAACGCTGGAGCGAGGCGGGGGCGGGTGAGGAGGGGGT
GACGCCGGACGCGTCGACAGCGCGAGGGTTCGCGCGTGAGCTGCGCGGGTCGGGCCTGGTACCGAGCTTTCCTGGGGGCTAGCAGGTCGT
GGACGCCGGCTCCTGGAGGAGAGCCGGTAGGAGGGAGTGTGAAGGTGTCCGCGGCGTCGTCGACGGCGGCGCCGGCCATGGAGGAGACGC
AGCCGCCGCCGCAGCCTAAGCTGCCCCTGTGCGACAGCCTCATGATCTGGCTCTTTCGACGTGTAGCAGCAGCTTTGCCGGGAATGGAAA
GCACACAGGACAGAAGCAGAGAAGATATGATTGACATAAAACTGGAAAAGCCTCAGGAGCAACCAGTCAGTGAAGGAGGCTGTTCCTGCT

>In-frame_ENST00000371208_ENST00000541588_TCGA-AR-A24Z-01A_HOOK1_chr1_60280852_+_RAB6A_chr11_73390765_length(amino acids)=140AA_start in transcript=421_stop in transcript=2
MLLRLFQFYVNHIFSASVLCAFHSRQSCCYTSKEPDHEAVAQGQLRLRRRLRLLHGRRRRRRRRGHLHTPSYRLSSRSRRPRPASPQESS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for HOOK1-RAB6A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for HOOK1-RAB6A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for HOOK1-RAB6A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source