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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:HOXB3-ALDOA (FusionGDB2 ID:37269)

Fusion Gene Summary for HOXB3-ALDOA

Fusion gene summary

Fusion gene information	Fusion gene name: HOXB3-ALDOA
	Fusion gene ID: 37269
		Hgene	Tgene
	Gene symbol	HOXB3	ALDOA
	Gene ID	3213	112694756
	Gene name	homeobox B3	uncharaterized LOC112694756
	Synonyms	HOX2\|HOX2G\|Hox-2.7	ALDA\|ALDOA
	Cytomap	17q21.32	-
	Type of gene	protein-coding	protein-coding
	Description	homeobox protein Hox-B3homeo box 2Ghomeobox protein Hox-2.7homeobox protein Hox-2G	uncharaterized LOC112694756Fructose-bisphosphate aldolase ALung cancer antigen NY-LU-1Muscle-type aldolase
	Modification date	20200313	20200303
	UniProtAcc	P14651	P04075
	Ensembl transtripts involved in fusion gene	ENST00000472863, ENST00000498678, ENST00000460160, ENST00000476342, ENST00000552000, ENST00000470495, ENST00000311626, ENST00000490677, ENST00000485909, ENST00000489475, ENST00000465120,	ENST00000338110, ENST00000395248, ENST00000575627, ENST00000566897, ENST00000569545, ENST00000563060, ENST00000412304, ENST00000564546, ENST00000564595, ENST00000569798, ENST00000395240,
Fusion gene scores	* DoF score	9 X 6 X 6=324	16 X 16 X 6=1536
	# samples	10	18
	** MAII score	log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1536*10)=-3.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: HOXB3 [Title/Abstract] AND ALDOA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HOXB3(46656333)-ALDOA(30081178), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HOXB3	GO:0045944	positive regulation of transcription by RNA polymerase II	9556594

Fusion gene breakpoints across HOXB3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ALDOA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BP428788	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+

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Fusion Gene ORF analysis for HOXB3-ALDOA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000472863	ENST00000338110	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000472863	ENST00000395248	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000472863	ENST00000575627	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000472863	ENST00000566897	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000472863	ENST00000569545	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000472863	ENST00000563060	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000472863	ENST00000412304	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000472863	ENST00000564546	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000472863	ENST00000564595	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000472863	ENST00000569798	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000472863	ENST00000395240	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000498678	ENST00000338110	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000498678	ENST00000395248	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000498678	ENST00000575627	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000498678	ENST00000566897	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000498678	ENST00000569545	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000498678	ENST00000563060	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000498678	ENST00000412304	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000498678	ENST00000564546	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000498678	ENST00000564595	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000498678	ENST00000569798	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000498678	ENST00000395240	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000460160	ENST00000338110	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000460160	ENST00000395248	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000460160	ENST00000575627	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000460160	ENST00000566897	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000460160	ENST00000569545	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000460160	ENST00000563060	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000460160	ENST00000412304	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000460160	ENST00000564546	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000460160	ENST00000564595	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000460160	ENST00000569798	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000460160	ENST00000395240	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000476342	ENST00000338110	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000476342	ENST00000395248	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000476342	ENST00000575627	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000476342	ENST00000566897	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000476342	ENST00000569545	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000476342	ENST00000563060	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000476342	ENST00000412304	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000476342	ENST00000564546	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000476342	ENST00000564595	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000476342	ENST00000569798	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000476342	ENST00000395240	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000552000	ENST00000338110	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000552000	ENST00000395248	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000552000	ENST00000575627	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000552000	ENST00000566897	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000552000	ENST00000569545	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000552000	ENST00000563060	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000552000	ENST00000412304	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000552000	ENST00000564546	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000552000	ENST00000564595	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000552000	ENST00000569798	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000552000	ENST00000395240	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000470495	ENST00000338110	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000470495	ENST00000395248	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000470495	ENST00000575627	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000470495	ENST00000566897	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000470495	ENST00000569545	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000470495	ENST00000563060	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000470495	ENST00000412304	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000470495	ENST00000564546	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000470495	ENST00000564595	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000470495	ENST00000569798	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000470495	ENST00000395240	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000311626	ENST00000338110	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000311626	ENST00000395248	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000311626	ENST00000575627	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000311626	ENST00000566897	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000311626	ENST00000569545	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000311626	ENST00000563060	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000311626	ENST00000412304	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000311626	ENST00000564546	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000311626	ENST00000564595	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000311626	ENST00000569798	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000311626	ENST00000395240	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000490677	ENST00000338110	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000490677	ENST00000395248	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000490677	ENST00000575627	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000490677	ENST00000566897	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000490677	ENST00000569545	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000490677	ENST00000563060	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000490677	ENST00000412304	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000490677	ENST00000564546	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000490677	ENST00000564595	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000490677	ENST00000569798	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000490677	ENST00000395240	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000485909	ENST00000338110	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000485909	ENST00000395248	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000485909	ENST00000575627	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000485909	ENST00000566897	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000485909	ENST00000569545	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000485909	ENST00000563060	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000485909	ENST00000412304	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000485909	ENST00000564546	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000485909	ENST00000564595	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000485909	ENST00000569798	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000485909	ENST00000395240	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000489475	ENST00000338110	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000489475	ENST00000395248	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000489475	ENST00000575627	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000489475	ENST00000566897	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000489475	ENST00000569545	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000489475	ENST00000563060	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000489475	ENST00000412304	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000489475	ENST00000564546	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000489475	ENST00000564595	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000489475	ENST00000569798	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000489475	ENST00000395240	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000465120	ENST00000338110	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-3CDS	ENST00000465120	ENST00000395248	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000465120	ENST00000575627	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000465120	ENST00000566897	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000465120	ENST00000569545	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000465120	ENST00000563060	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000465120	ENST00000412304	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000465120	ENST00000564546	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000465120	ENST00000564595	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000465120	ENST00000569798	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+
intron-intron	ENST00000465120	ENST00000395240	HOXB3	chr17	46656333	+	ALDOA	chr16	30081178	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for HOXB3-ALDOA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HOXB3-ALDOA

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HOXB3 P14651	ALDOA P04075
FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.	FUNCTION: Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for HOXB3-ALDOA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HOXB3-ALDOA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for HOXB3-ALDOA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	ALDOA	P04075	DB14548	Zinc sulfate, unspecified form	Ligand	Small molecule	Approved\|Experimental
Tgene	ALDOA	P04075	DB14548	Zinc sulfate, unspecified form	Ligand	Small molecule	Approved\|Experimental
Tgene	ALDOA	P04075	DB01593	Zinc		Small molecule	Approved\|Investigational
Tgene	ALDOA	P04075	DB01593	Zinc		Small molecule	Approved\|Investigational
Tgene	ALDOA	P04075	DB14487	Zinc acetate		Small molecule	Approved\|Investigational
Tgene	ALDOA	P04075	DB14487	Zinc acetate		Small molecule	Approved\|Investigational
Tgene	ALDOA	P04075	DB14533	Zinc chloride	Ligand	Small molecule	Approved\|Investigational
Tgene	ALDOA	P04075	DB14533	Zinc chloride	Ligand	Small molecule	Approved\|Investigational

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Related Diseases for HOXB3-ALDOA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HOXB3	C0019284	Diaphragmatic Hernia	1	CTD_human
Tgene	ALDOA	C0272066	Glycogen Storage Disease XII	7	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	ALDOA	C0017919	Glycogen Storage Disease	3	GENOMICS_ENGLAND
Tgene	ALDOA	C0520572	Enzymopathy	2	GENOMICS_ENGLAND
Tgene	ALDOA	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	ALDOA	C0027626	Neoplasm Invasiveness	1	CTD_human
Tgene	ALDOA	C0027627	Neoplasm Metastasis	1	CTD_human
Tgene	ALDOA	C0151744	Myocardial Ischemia	1	CTD_human
Tgene	ALDOA	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
Tgene	ALDOA	C0678222	Breast Carcinoma	1	CTD_human
Tgene	ALDOA	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	ALDOA	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	ALDOA	C4704874	Mammary Carcinoma, Human	1	CTD_human