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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HP1BP3-PINK1 (FusionGDB2 ID:37331)

Fusion Gene Summary for HP1BP3-PINK1

check button Fusion gene summary
Fusion gene informationFusion gene name: HP1BP3-PINK1
Fusion gene ID: 37331
HgeneTgene
Gene symbol

HP1BP3

PINK1

Gene ID

50809

65018

Gene nameheterochromatin protein 1 binding protein 3PTEN induced kinase 1
SynonymsHP1-BP74|HP1BP74BRPK|PARK6
Cytomap

1p36.12

1p36.12

Type of geneprotein-codingprotein-coding
Descriptionheterochromatin protein 1-binding protein 3serine/threonine-protein kinase PINK1, mitochondrialPTEN induced putative kinase 1PTEN-induced putative kinase protein 1protein kinase BRPK
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000312239, ENST00000487117, 
ENST00000375000, ENST00000375003, 
ENST00000321556, ENST00000492302, 
Fusion gene scores* DoF score11 X 8 X 7=6163 X 5 X 2=30
# samples 125
** MAII scorelog2(12/616*10)=-2.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HP1BP3 [Title/Abstract] AND PINK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHP1BP3(21103090)-PINK1(20970983), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHP1BP3

GO:0071456

cellular response to hypoxia

25100860

TgenePINK1

GO:0001934

positive regulation of protein phosphorylation

25244949

TgenePINK1

GO:0002082

regulation of oxidative phosphorylation

20871098

TgenePINK1

GO:0006468

protein phosphorylation

14607334|21177249|25527291

TgenePINK1

GO:0018105

peptidyl-serine phosphorylation

17579517|19880420

TgenePINK1

GO:0031396

regulation of protein ubiquitination

19880420

TgenePINK1

GO:0033138

positive regulation of peptidyl-serine phosphorylation

21177249

TgenePINK1

GO:0035556

intracellular signal transduction

14607334

TgenePINK1

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

19880420

TgenePINK1

GO:0043254

regulation of protein complex assembly

19880420

TgenePINK1

GO:1903202

negative regulation of oxidative stress-induced cell death

16632486

TgenePINK1

GO:1903214

regulation of protein targeting to mitochondrion

25244949

TgenePINK1

GO:1903384

negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway

21177249

TgenePINK1

GO:1903751

negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide

17579517

TgenePINK1

GO:2001243

negative regulation of intrinsic apoptotic signaling pathway

15087508


check buttonFusion gene breakpoints across HP1BP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PINK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A8DV-01AHP1BP3chr1

21103090

-PINK1chr1

20970983

+
ChimerDB4STADTCGA-VQ-A8DV-01AHP1BP3chr1

21103090

-PINK1chr1

20970983

+


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Fusion Gene ORF analysis for HP1BP3-PINK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000312239ENST00000321556HP1BP3chr1

21103090

-PINK1chr1

20970983

+
5CDS-3UTRENST00000312239ENST00000492302HP1BP3chr1

21103090

-PINK1chr1

20970983

+
intron-3CDSENST00000487117ENST00000321556HP1BP3chr1

21103090

-PINK1chr1

20970983

+
intron-3UTRENST00000487117ENST00000492302HP1BP3chr1

21103090

-PINK1chr1

20970983

+
In-frameENST00000375000ENST00000321556HP1BP3chr1

21103090

-PINK1chr1

20970983

+
5CDS-3UTRENST00000375000ENST00000492302HP1BP3chr1

21103090

-PINK1chr1

20970983

+
intron-3CDSENST00000375003ENST00000321556HP1BP3chr1

21103090

-PINK1chr1

20970983

+
intron-3UTRENST00000375003ENST00000492302HP1BP3chr1

21103090

-PINK1chr1

20970983

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000312239HP1BP3chr121103090-ENST00000321556PINK1chr120970983+22804901401459439
ENST00000375000HP1BP3chr121103090-ENST00000321556PINK1chr120970983+23675772271546439

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000312239ENST00000321556HP1BP3chr121103090-PINK1chr120970983+0.0049105990.9950895
ENST00000375000ENST00000321556HP1BP3chr121103090-PINK1chr120970983+0.0054785760.9945214

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Fusion Genomic Features for HP1BP3-PINK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HP1BP3chr121103089-PINK1chr120970982+1.10E-091
HP1BP3chr121103089-PINK1chr120970982+1.10E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HP1BP3-PINK1


check button Go to

FGviewer for the breakpoints of chr1:21103090-chr1:20970983

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000312239-413454_553116.66666666666667554.0Compositional biasNote=Lys-rich
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375000-45454_553116.66666666666667134.0Compositional biasNote=Lys-rich
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375003-19454_5530402.0Compositional biasNote=Lys-rich
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000312239-413157_232116.66666666666667554.0DomainH15 1
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000312239-413255_330116.66666666666667554.0DomainH15 2
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000312239-413337_413116.66666666666667554.0DomainH15 3
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375000-45157_232116.66666666666667134.0DomainH15 1
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375000-45255_330116.66666666666667134.0DomainH15 2
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375000-45337_413116.66666666666667134.0DomainH15 3
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375003-19157_2320402.0DomainH15 1
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375003-19255_3300402.0DomainH15 2
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375003-19337_4130402.0DomainH15 3
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000312239-413255_259116.66666666666667554.0MotifPxVxL motif
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375000-45255_259116.66666666666667134.0MotifPxVxL motif
HgeneHP1BP3chr1:21103090chr1:20970983ENST00000375003-19255_2590402.0MotifPxVxL motif
TgenePINK1chr1:21103090chr1:20970983ENST0000032155628156_511258.6666666666667582.0DomainProtein kinase
TgenePINK1chr1:21103090chr1:20970983ENST0000032155628162_170258.6666666666667582.0Nucleotide bindingATP
TgenePINK1chr1:21103090chr1:20970983ENST0000032155628111_117258.6666666666667582.0RegionRequired for outer membrane localization
TgenePINK1chr1:21103090chr1:20970983ENST0000032155628111_581258.6666666666667582.0Topological domainCytoplasmic
TgenePINK1chr1:21103090chr1:20970983ENST000003215562878_93258.6666666666667582.0Topological domainMitochondrial intermembrane
TgenePINK1chr1:21103090chr1:20970983ENST000003215562894_110258.6666666666667582.0TransmembraneHelical


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Fusion Gene Sequence for HP1BP3-PINK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000312239_ENST00000321556_TCGA-VQ-A8DV-01A_HP1BP3_chr1_21103090_-_PINK1_chr1_20970983_length(transcript)=2280nt_BP=490nt
GTTCTCCGCCCCCGCCGCCGCCATTACGGAGCTCCCAGTGGTTGATTCTTCACCACACTGAAACCATTAGGAAAAATCCTTGTGGTTAAC
AGCAGAGGCTTCAGAGTGTAACCTGTACTCGGGCCTAGAAATTATTTAAAATGGCGACTGATACGTCTCAAGGTGAACTCGTCCATCCTA
AGGCACTCCCACTTATAGTAGGAGCTCAGCTGATCCACGCGGACAAGTTAGGTGAGAAGGTAGAAGATAGCACCATGCCGATTCGTCGAA
CTGTGAATTCTACCCGGGAAACTCCTCCCAAAAGCAAGCTTGCTGAAGGGGAGGAAGAAAAGCCAGAACCAGACATAAGTTCAGAGGAAT
CTGTCTCCACTGTAGAAGAACAAGAGAATGAAACTCCACCTGCTACTTCGAGTGAGGCAGAGCAGCCAAAGGGGGAACCTGAGAATGAAG
AGAAGGAAGAAAATAAGTCTTCTGAGGAAACCAAAAAGGAAAAATCCAAGAGAGGTCCCAAGCAACTAGCCCCTCACCCCAACATCATCC
GGGTTCTCCGCGCCTTCACCTCTTCCGTGCCGCTGCTGCCAGGGGCCCTGGTCGACTACCCTGATGTGCTGCCCTCACGCCTCCACCCTG
AAGGCCTGGGCCATGGCCGGACGCTGTTCCTCGTTATGAAGAACTATCCCTGTACCCTGCGCCAGTACCTTTGTGTGAACACACCCAGCC
CCCGCCTCGCCGCCATGATGCTGCTGCAGCTGCTGGAAGGCGTGGACCATCTGGTTCAACAGGGCATCGCGCACAGAGACCTGAAATCCG
ACAACATCCTTGTGGAGCTGGACCCAGACGGCTGCCCCTGGCTGGTGATCGCAGATTTTGGCTGCTGCCTGGCTGATGAGAGCATCGGCC
TGCAGTTGCCCTTCAGCAGCTGGTACGTGGATCGGGGCGGAAACGGCTGTCTGATGGCCCCAGAGGTGTCCACGGCCCGTCCTGGCCCCA
GGGCAGTGATTGACTACAGCAAGGCTGATGCCTGGGCAGTGGGAGCCATCGCCTATGAAATCTTCGGGCTTGTCAATCCCTTCTACGGCC
AGGGCAAGGCCCACCTTGAAAGCCGCAGCTACCAAGAGGCTCAGCTACCTGCACTGCCCGAGTCAGTGCCTCCAGACGTGAGACAGTTGG
TGAGGGCACTGCTCCAGCGAGAGGCCAGCAAGAGACCATCTGCCCGAGTAGCCGCAAATGTGCTTCATCTAAGCCTCTGGGGTGAACATA
TTCTAGCCCTGAAGAATCTGAAGTTAGACAAGATGGTTGGCTGGCTCCTCCAACAATCGGCCGCCACTTTGTTGGCCAACAGGCTCACAG
AGAAGTGTTGTGTGGAAACAAAAATGAAGATGCTCTTTCTGGCTAACCTGGAGTGTGAAACGCTCTGCCAGGCAGCCCTCCTCCTCTGCT
CATGGAGGGCAGCCCTGTGATGTCCCTGCATGGAGCTGGTGAATTACTAAAAGAACATGGCATCCTCTGTGTCGTGATGGTCTGTGAATG
GTGAGGGTGGGAGTCAGGAGACAAGACAGCGCAGAGAGGGCTGGTTAGCCGGAAAAGGCCTCGGGCTTGGCAAATGGAAGAACTTGAGTG
AGAGTTCAGTCTGCAGTCCTCTGCTCACAGACATCTGAAAAGTGAATGGCCAAGCTGGTCTAGTAGATGAGGCTGGACTGAGGAGGGGTA
GGCCTGCATCCACAGAGAGGATCCAGGCCAAGGCACTGGCTGTCAGTGGCAGAGTTTGGCTGTGACCTTTGCCCCTAACACGAGGAACTC
GTTTGAAGGGGGCAGCGTAGCATGTCTGATTTGCCACCTGGATGAAGGCAGACATCAACATGGGTCAGCACGTTCAGTTACGGGAGTGGG
AAATTACATGAGGCCTGGGCCTCTGCGTTCCCAAGCTGTGCGTTCTGGACCAGCTACTGAATTATTAATCTCACTTAGCGAAAGTGACGG
ATGAGCAGTAAGTAAGTAAGTGTGGGGATTTAAACTTGAGGGTTTCCCTCCTGACTAGCCTCTCTTACAGGAATTGTGAAATATTAAATG
CAAATTTACAACTGCAGATGACGTATGTGCCTTGAACTGAATATTTGGCTTTAAGAATGATTCTTATACTCTGAAGGTGAGAATATTTTG
TGGGCAGGTATCAACATTGGGGAAGAGATTTCATGTCTAACTAACTAACTTTATACATGATTTTTAGGAAGCTATTGCCTAAATCAGCGT

>In-frame_ENST00000312239_ENST00000321556_TCGA-VQ-A8DV-01A_HP1BP3_chr1_21103090_-_PINK1_chr1_20970983_length(amino acids)=439AA_start in transcript=140_stop in transcript=1459
MATDTSQGELVHPKALPLIVGAQLIHADKLGEKVEDSTMPIRRTVNSTRETPPKSKLAEGEEEKPEPDISSEESVSTVEEQENETPPATS
SEAEQPKGEPENEEKEENKSSEETKKEKSKRGPKQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVLPSRLHPEGLGHGRTLFLVMKNYP
CTLRQYLCVNTPSPRLAAMMLLQLLEGVDHLVQQGIAHRDLKSDNILVELDPDGCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGC
LMAPEVSTARPGPRAVIDYSKADAWAVGAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALPESVPPDVRQLVRALLQREASKRPSARV

--------------------------------------------------------------
>In-frame_ENST00000375000_ENST00000321556_TCGA-VQ-A8DV-01A_HP1BP3_chr1_21103090_-_PINK1_chr1_20970983_length(transcript)=2367nt_BP=577nt
GCGGAGCGCCGAGGCTCGCGTTCCGCCGCTGCTTCCGTCGCCGGGGCGGGCGCCGCGGTGTCCCTGCCGAGCGTGAGCCCCGAACTGTCA
CCGCGCCGAGCCCCAGCCTCATCCGTCGGTGTCCGCGGTTGATTCTTCACCACACTGAAACCATTAGGAAAAATCCTTGTGGTTAACAGC
AGAGGCTTCAGAGTGTAACCTGTACTCGGGCCTAGAAATTATTTAAAATGGCGACTGATACGTCTCAAGGTGAACTCGTCCATCCTAAGG
CACTCCCACTTATAGTAGGAGCTCAGCTGATCCACGCGGACAAGTTAGGTGAGAAGGTAGAAGATAGCACCATGCCGATTCGTCGAACTG
TGAATTCTACCCGGGAAACTCCTCCCAAAAGCAAGCTTGCTGAAGGGGAGGAAGAAAAGCCAGAACCAGACATAAGTTCAGAGGAATCTG
TCTCCACTGTAGAAGAACAAGAGAATGAAACTCCACCTGCTACTTCGAGTGAGGCAGAGCAGCCAAAGGGGGAACCTGAGAATGAAGAGA
AGGAAGAAAATAAGTCTTCTGAGGAAACCAAAAAGGAAAAATCCAAGAGAGGTCCCAAGCAACTAGCCCCTCACCCCAACATCATCCGGG
TTCTCCGCGCCTTCACCTCTTCCGTGCCGCTGCTGCCAGGGGCCCTGGTCGACTACCCTGATGTGCTGCCCTCACGCCTCCACCCTGAAG
GCCTGGGCCATGGCCGGACGCTGTTCCTCGTTATGAAGAACTATCCCTGTACCCTGCGCCAGTACCTTTGTGTGAACACACCCAGCCCCC
GCCTCGCCGCCATGATGCTGCTGCAGCTGCTGGAAGGCGTGGACCATCTGGTTCAACAGGGCATCGCGCACAGAGACCTGAAATCCGACA
ACATCCTTGTGGAGCTGGACCCAGACGGCTGCCCCTGGCTGGTGATCGCAGATTTTGGCTGCTGCCTGGCTGATGAGAGCATCGGCCTGC
AGTTGCCCTTCAGCAGCTGGTACGTGGATCGGGGCGGAAACGGCTGTCTGATGGCCCCAGAGGTGTCCACGGCCCGTCCTGGCCCCAGGG
CAGTGATTGACTACAGCAAGGCTGATGCCTGGGCAGTGGGAGCCATCGCCTATGAAATCTTCGGGCTTGTCAATCCCTTCTACGGCCAGG
GCAAGGCCCACCTTGAAAGCCGCAGCTACCAAGAGGCTCAGCTACCTGCACTGCCCGAGTCAGTGCCTCCAGACGTGAGACAGTTGGTGA
GGGCACTGCTCCAGCGAGAGGCCAGCAAGAGACCATCTGCCCGAGTAGCCGCAAATGTGCTTCATCTAAGCCTCTGGGGTGAACATATTC
TAGCCCTGAAGAATCTGAAGTTAGACAAGATGGTTGGCTGGCTCCTCCAACAATCGGCCGCCACTTTGTTGGCCAACAGGCTCACAGAGA
AGTGTTGTGTGGAAACAAAAATGAAGATGCTCTTTCTGGCTAACCTGGAGTGTGAAACGCTCTGCCAGGCAGCCCTCCTCCTCTGCTCAT
GGAGGGCAGCCCTGTGATGTCCCTGCATGGAGCTGGTGAATTACTAAAAGAACATGGCATCCTCTGTGTCGTGATGGTCTGTGAATGGTG
AGGGTGGGAGTCAGGAGACAAGACAGCGCAGAGAGGGCTGGTTAGCCGGAAAAGGCCTCGGGCTTGGCAAATGGAAGAACTTGAGTGAGA
GTTCAGTCTGCAGTCCTCTGCTCACAGACATCTGAAAAGTGAATGGCCAAGCTGGTCTAGTAGATGAGGCTGGACTGAGGAGGGGTAGGC
CTGCATCCACAGAGAGGATCCAGGCCAAGGCACTGGCTGTCAGTGGCAGAGTTTGGCTGTGACCTTTGCCCCTAACACGAGGAACTCGTT
TGAAGGGGGCAGCGTAGCATGTCTGATTTGCCACCTGGATGAAGGCAGACATCAACATGGGTCAGCACGTTCAGTTACGGGAGTGGGAAA
TTACATGAGGCCTGGGCCTCTGCGTTCCCAAGCTGTGCGTTCTGGACCAGCTACTGAATTATTAATCTCACTTAGCGAAAGTGACGGATG
AGCAGTAAGTAAGTAAGTGTGGGGATTTAAACTTGAGGGTTTCCCTCCTGACTAGCCTCTCTTACAGGAATTGTGAAATATTAAATGCAA
ATTTACAACTGCAGATGACGTATGTGCCTTGAACTGAATATTTGGCTTTAAGAATGATTCTTATACTCTGAAGGTGAGAATATTTTGTGG
GCAGGTATCAACATTGGGGAAGAGATTTCATGTCTAACTAACTAACTTTATACATGATTTTTAGGAAGCTATTGCCTAAATCAGCGTCAA

>In-frame_ENST00000375000_ENST00000321556_TCGA-VQ-A8DV-01A_HP1BP3_chr1_21103090_-_PINK1_chr1_20970983_length(amino acids)=439AA_start in transcript=227_stop in transcript=1546
MATDTSQGELVHPKALPLIVGAQLIHADKLGEKVEDSTMPIRRTVNSTRETPPKSKLAEGEEEKPEPDISSEESVSTVEEQENETPPATS
SEAEQPKGEPENEEKEENKSSEETKKEKSKRGPKQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVLPSRLHPEGLGHGRTLFLVMKNYP
CTLRQYLCVNTPSPRLAAMMLLQLLEGVDHLVQQGIAHRDLKSDNILVELDPDGCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGC
LMAPEVSTARPGPRAVIDYSKADAWAVGAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALPESVPPDVRQLVRALLQREASKRPSARV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HP1BP3-PINK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HP1BP3-PINK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HP1BP3-PINK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHP1BP3C0221074Depression, Postpartum1PSYGENET
TgenePINK1C1853833Parkinson Disease 6, Autosomal Recessive Early-Onset27CTD_human;GENOMICS_ENGLAND;UNIPROT
TgenePINK1C0242422Parkinsonian Disorders6CTD_human
TgenePINK1C0242423Ramsay Hunt Paralysis Syndrome6CTD_human
TgenePINK1C0752097Autosomal Dominant Juvenile Parkinson Disease6CTD_human
TgenePINK1C0752098Autosomal Dominant Parkinsonism6CTD_human
TgenePINK1C0752100Autosomal Recessive Parkinsonism6CTD_human
TgenePINK1C0752101Parkinsonism, Experimental6CTD_human
TgenePINK1C0752104Familial Juvenile Parkinsonism6CTD_human
TgenePINK1C0752105Parkinsonism, Juvenile6CTD_human
TgenePINK1C1868675PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE6CTD_human
TgenePINK1C0030567Parkinson Disease5CTD_human
TgenePINK1C0036341Schizophrenia3PSYGENET
TgenePINK1C0013421Dystonia1GENOMICS_ENGLAND
TgenePINK1C0027746Nerve Degeneration1CTD_human
TgenePINK1C0027819Neuroblastoma1CTD_human
TgenePINK1C0041696Unipolar Depression1PSYGENET
TgenePINK1C1269683Major Depressive Disorder1PSYGENET